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https://www.readbyqxmd.com/read/28211317/primary-human-cytomegalovirus-hcmv-infection-in-pregnancy
#1
Horst Buxmann, Klaus Hamprecht, Matthias Meyer-Wittkopf, Klaus Friese
BACKGROUND: In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain, leading to motor and mental retardation, cerebral palsy, epilepsy, retinal defects, and progressive hearing loss. METHODS: This review is based on pertinent publications from January 2000 to October 2016 that were retrieved by a selective search in PubMed employing the terms "cytomegalovirus and pregnancy" and "congenital cytomegalovirus...
January 27, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28196356/therapeutic-hypothermia-provides-variable-protection-against-behavioral-deficits-after-neonatal-hypoxia-ischemia-a-potential-role-for-brain-derived-neurotrophic-factor
#2
Johana Diaz, Suleiman Abiola, Nancy Kim, Oliver Avaritt, Debra Flock, Jenny Yu, Frances J Northington, Raul Chavez-Valdez
BACKGROUND: Despite treatment with therapeutic hypothermia (TH), infants who survive hypoxic ischemic (HI) encephalopathy (HIE) have persistent neurological abnormalities at school age. Protection by TH against HI brain injury is variable in both humans and animal models. Our current preclinical model of hypoxia-ischemia (HI) and TH displays this variability of outcomes in neuropathological and neuroimaging end points with some sexual dimorphism. The detailed behavioral phenotype of this model is unknown...
February 15, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28169036/identification-of-risk-factors-for-poor-feeding-in-infants-with-congenital-heart-disease-and-a-novel-approach-to-improve-oral-feeding
#3
Gitanjali Indramohan, Tiffany P Pedigo, Nicole Rostoker, Mae Cambare, Tristan Grogan, Myke D Federman
Many infants with complex congenital heart disease (CHD) do not develop the skills to feed orally and are discharged home on gastrostomy tube or nasogastric feeds. We aimed to identify risk factors for failure to achieve full oral feeding and evaluate the efficacy of oral motor intervention for increasing the rate of discharge on full oral feeds by performing a prospective study in the neonatal and cardiac intensive care units of a tertiary children's hospital. 23 neonates born at ≥37weeks gestation and diagnosed with single-ventricle physiology requiring a surgical shunt were prospectively enrolled and received oral motor intervention therapy...
February 3, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28152334/a-comparison-of-the-efficacy-of-weight-shift-vs-joystick-control-of-a-robotic-mobility-device-by-infants-ages-5-to-10-months
#4
Sharon Stansfield, Carole Dennis, Rachel Altman, Janelle Smith, Hélène Larin
The onset of crawling in infants contributes to cognitive, perceptual, social, and emotional development. Conversely, infants with motor impairment that delays or prevents autonomous mobility often have associated developmental delays. Evidence suggests that providing mobility may have positive developmental outcomes, however powered wheelchairs may not be recommended for very young children, due to safety concerns and the child's level of cognitive maturity. The WeeBot is a mobility device controlled by infant weight shifting while seated; infants as young as 5 months have learned to use it...
February 2, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28152144/association-between-moderate-and-late-preterm-birth-and-neurodevelopment-and-social-emotional-development-at-age-2-years
#5
Jeanie L Cheong, Lex W Doyle, Alice C Burnett, Katherine J Lee, Jennifer M Walsh, Cody R Potter, Karli Treyvaud, Deanne K Thompson, Joy E Olsen, Peter J Anderson, Alicia J Spittle
Importance: Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. Objective: To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years...
February 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28146204/development-skills-of-children-born-premature-with-low-and-very-low-birth-weight
#6
Camila da Costa Ribeiro, Mariane Regina de Oliveira Pachelli, Natalie Camillo de Oliveira Amaral, Dionísia Aparecida Cusin Lamônica
Purpose: To compare the performance of children born premature with low birth weight (LBW) and very low birth-weight (VLBW) with that of children born at term, within the age range of one to three years, regarding child development in the gross motor, fine motor-adaptive, personal-social and language domains. Methods: This is a cross-sectional study in a cohort of 150 infants born premature (experimental group) and at term (control group) divided into eight groups with respect to weight (low birth weight: <2500 grams and very low birth weight: <1500 grams) and age range (aged 12 to 24 and 25 to 36 months)...
January 30, 2017: CoDAS
https://www.readbyqxmd.com/read/28133900/the-effect-of-subclinical-infantile-thiamine-deficiency-on-motor-function-in-preschool-children
#7
Yael Harel, Luba Zuk, Michal Guindy, Orly Nakar, Dafna Lotan, Aviva Fattal-Valevski
We investigated the long-term implications of infantile thiamine (vitamin B1) deficiency on motor function in preschoolers who had been fed during the first 2 years of life with a faulty milk substitute. In this retrospective cohort study, 39 children aged 5-6 years who had been exposed to a thiamine-deficient formula during infancy were compared with 30 age-matched healthy children with unremarkable infant nutritional history. The motor function of the participants was evaluated with The Movement Assessment Battery for Children (M-ABC) and the Zuk Assessment...
January 29, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28129748/the-speed-of-increasing-milk-feeds-a-randomised-controlled-trial
#8
Jane Abbott, Janet Berrington, Ursula Bowler, Elaine Boyle, Jon Dorling, Nicholas Embleton, Edmund Juszczak, Alison Leaf, Louise Linsell, Samantha Johnson, Kenny McCormick, William McGuire, Tracy Roberts, Ben Stenson
BACKGROUND: In the UK, 1-2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1500 g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutrition. Milk feeding strategies influence several long and short term health outcomes including growth, survival, infection (associated with intravenous nutrition) and necrotising enterocolitis (NEC); with both infection and NEC being key predictive factors of long term disability...
January 28, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28110393/nitric-oxide-production-in-the-striatum-and-cerebellum-of-a-rat-model-of-preterm-global-perinatal-asphyxia
#9
M Barkhuizen, W D J Van de Berg, J De Vente, C E Blanco, A W D Gavilanes, H W M Steinbusch
Encephalopathy due to perinatal asphyxia (PA) is a major cause of neonatal morbidity and mortality in the period around birth. Preterm infants are especially at risk for cognitive, attention and motor impairments. Therapy for this subgroup is limited to supportive care, and new targets are thus urgently needed. Post-asphyxic excitotoxicity is partially mediated by excessive nitric oxide (NO) release. The aims of this study were to determine the timing and distribution of nitric oxide (NO) production after global PA in brain areas involved in motor regulation and coordination...
January 21, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28108580/chronic-conditions-and-health-care-needs-of-adolescents-born-at-23-to-25-weeks-gestation
#10
Antti Holsti, Marie Adamsson, Bruno Hägglöf, Aijaz Farooqi, Fredrik Serenius
OBJECTIVE: We examined chronic conditions, functional limitations, and special health care needs in extremely preterm children (EPT; 23-25 weeks' gestation) born between 1992 and 1998 at 2 Swedish tertiary care centers that offered regional and active perinatal care to all live-born EPT infants. METHODS: Of 134 surviving EPT children, 132 (98%) were assessed at 10 to 15 years of age alongside 103 term-born controls. Identification of children with functional limitations and special health care needs was based on a questionnaire administered to parents...
January 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28088692/evaluation-of-motor-and-cognitive-development-among-infants-exposed-to-hiv
#11
Kaitiana Martins da Silva, Cristina Dos Santos Cardoso de Sá, Raquel Carvalho
This study of a prospective and cross-sectional nature compared the motor and cognitive development of HIV-exposed and unexposed infants in their first 18months of age. 40 infants exposed to HIV and antiretroviral therapy (Experimental Group - EG) and 40 unexposed infants (Control Group - CG) participated in the study. They were divided into four age groups of 4, 8, 12 and 18months old, with 10 infants from EG and 10 from CG in each group. The infants were evaluated once on motor and cognitive development by the Bayley Scale of Infant and Toddler Development...
January 12, 2017: Early Human Development
https://www.readbyqxmd.com/read/28087725/neurodevelopmental-outcomes-of-extremely-low-birthweight-infants-randomised-to-different-pco2-targets-the-phelbi-follow-up-study
#12
Ulrich H Thome, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Annett Bläser, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Maria Zernickel, Harald Bode, Jens Dreyhaupt, Rainer Muche, Helmut D Hummler
BACKGROUND: Tolerating higher partial pressures of carbon dioxide (PCO2) in mechanically ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may have long-term neurodevelopmental side effects. This study analyses the results of neurodevelopmental follow-up of infants enrolled in a randomised multicentre trial. METHODS: Infants (n=359) between 400 and 1000 g birth weight and 23 0/7-28 6/7 weeks gestational age who required endotracheal intubation and mechanical ventilation within 24 hours of birth were randomly assigned to high PCO2 or to a control group with mildly elevated PCO2 targets...
January 13, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28068465/one-year-developmental-outcomes-for-infants-of-mothers-with-bipolar-disorder
#13
Aimee K Santucci, Lynn T Singer, Stephen R Wisniewski, James F Luther, Heather F Eng, Dorothy K Sit, Katherine L Wisner
OBJECTIVE: Few data about the development of infants born to women with bipolar disorder have been published. We hypothesized that infants of women with bipolar disorder (by DSM-IV criteria) treated with psychotropics (BD+) or untreated with psychotropics (BD-) would demonstrate poorer cognitive and behavioral development than infants of controls. On the basis of previous studies, we expected that psychotropic-exposed infants of women in the BD+ group would have poorer neuromotor performance during infancy...
January 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28059457/the-many-facets-of-speech-production-and-its-complex-effects-on-phonological-processing
#14
Tania S Zamuner, H Henny Yeung, Myriam Ducos
In our commentary, we discuss two additional points about developmental speech production. First, we suggest that more precision is needed to accurately describe 'speech production' processes, and we suggest that hierarchical constructs from the adult literatures on articulatory phonology and speech motor control may be applicable to infants as well. Second, we discuss the implications from data that indicate that the effects of production are subject to task-, attentional-, linguistic-, and experience-related demands...
February 2017: British Journal of Psychology
https://www.readbyqxmd.com/read/28049268/local-food-supplementation-and-psychosocial-stimulation-improve-linear-growth-and-cognitive-development-among-indonesian-infants-aged-6-to-9-months
#15
Helmizar Helmizar, Fasli Jalal, Nur Indrawati Lipoeto, Endang L Achadi
BACKGROUND AND OBJECTIVES: To evaluate the effect of culturally-relevant food supplementation and psychosocial stimulation on infant growth and development. METHODS AND STUDY DESIGN: A community-based randomized controlled trial was conducted in 40 clusters from 5 selected villages in Tanah Datar District of West Sumatera, Indonesia. We assessed 355 infants aged 6 to 9 months at the beginning of the study. The infants were divided into 4 groups: 1) Food Supplementation (FS); 2) Psychosocial Stimulation (PS); 3) Food Supplementation and Psychosocial Stimulation (FS+PS); and 4) Control Group (CG)...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28026189/infants-prospectively-control-reaching-based-on-the-difficulty-of-future-actions-to-what-extent-can-infants-multiple-step-actions-be-explained-by-fitts-law
#16
Janna M Gottwald, Aurora De Bortoli Vizioli, Marcus Lindskog, Pär Nyström, Therese L Ekberg, Claes von Hofsten, Gustaf Gredebäck
Prospective motor control, a key element of action planning, is the ability to adjust one's actions with respect to task demands and action goals in an anticipatory manner. The current study investigates whether 14-month-olds can prospectively control their reaching actions based on the difficulty of the subsequent action. We used a reach-to-place task, with difficulty of the placing action varied by goal size and goal distance. To target prospective motor control, we determined the kinematics of the prior reaching movements using a motion-tracking system...
January 2017: Developmental Psychology
https://www.readbyqxmd.com/read/27984231/effects-of-cycled-lighting-versus-continuous-near-darkness-on-physiological-stability-and-motor-activity-level-in-preterm-infants
#17
Valérie Lebel, Marilyn Aita, Celeste Johnston, Marjolaine Héon, France Dupuis
BACKGROUND: Preterm infants generally spend weeks in the neonatal intensive care unit where light intensity can fluctuate as well as be high, leading to physiological instability and increased motor activity in these infants. To date, 2 lighting control methods have been studied: cycled lighting and continuous near darkness. The most appropriate method of lighting is still unknown due to ambivalent results from the studies that have assessed these 2 interventions. OBJECTIVE: To compare the effects of cycled lighting versus continuous near darkness on physiological stability and motor activity level in preterm infants born between 28 and 32 weeks of gestation...
December 15, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27955652/early-skin-to-skin-contact-or-incubator-for-very-preterm-infants-study-protocol-for-a-randomized-controlled-trial
#18
Laila Kristoffersen, Ragnhild Støen, Hilde Rygh, Margunn Sognnæs, Turid Follestad, Hilde S Mohn, Ingrid Nissen, Håkon Bergseng
BACKGROUND: Skin-to-skin care immediately following delivery is a common practice for term infants and has been shown to improve cardiorespiratory stability, facilitate early bonding, and promote breastfeeding. Since 2007, the use of skin-to-skin care has been practiced for preterm infants from 32 weeks of gestation in the delivery room at St. Olav's University Hospital. In the present study we aim to investigate whether skin-to-skin care following delivery is safe, and how it affects early and late outcomes compared to standard care for very preterm infants...
December 12, 2016: Trials
https://www.readbyqxmd.com/read/27940687/survival-and-neurodevelopmental-outcomes-of-preterms-resuscitated-with-different-oxygen-fractions
#19
Nuria Boronat, Marta Aguar, Denise Rook, Martin Iriondo, María Brugada, María Cernada, Antonio Nuñez, Montserrat Izquierdo, Elena Cubells, María Martinez, Anna Parra, Hans van Goudoever, Máximo Vento
BACKGROUND AND OBJECTIVES: Stabilization of preterm infants after birth frequently requires oxygen supplementation. At present the optimal initial oxygen inspiratory fraction (Fio2) for preterm stabilization after birth is still under debate. We aimed to compare neurodevelopmental outcomes of extremely preterm infants at 24 months corrected age randomly assigned to be stabilized after birth with an initial Fio2 of 0.3 versus 0.6 to 0.65 in 3 academic centers from Spain and the Netherlands...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27940686/school-age-outcomes-of-early-intervention-for-preterm-infants-and-their-parents-a-randomized-trial
#20
Alicia J Spittle, Sarah Barton, Karli Treyvaud, Carly S Molloy, Lex W Doyle, Peter J Anderson
OBJECTIVE: To examine the child and parental outcomes at school age of a randomized controlled trial of a home-based early preventative care program for infants born very preterm and their caregivers. METHODS: At term-equivalent age, 120 infants born at a gestational age of <30 weeks were randomly allocated to intervention (n = 61) or standard care (n = 59) groups. The intervention included 9 home visits over the first year of life focusing on infant development, parental mental health, and the parent-infant relationship...
December 2016: Pediatrics
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