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https://www.readbyqxmd.com/read/29023666/nutritional-intervention-and-neurodevelopmental-outcome-in-infants-with-suspected-cerebral-palsy-the-dolphin-infant-double-blind-randomized-controlled-trial
#1
Morag J Andrew, Jeremy R Parr, Christine Montague-Johnson, Karen Laler, Cathy Qi, Bonny Baker, Peter B Sullivan
AIM: To investigate whether docosahexaenoic acid (DHA), choline, and uridine-5-monophosphate (UMP) supplementation improves neurodevelopmental outcome in infants with suspected cerebral palsy (CP) versus a comparison group of children. METHOD: Infants aged 1 to 18 months with suspected CP were recruited from UK child development centres. Participants received daily treatment or control supplementation for 2 years (double-blind randomized control design). Stratification was by age, sex, predominant pattern of motor involvement (four limbs or other), and visual impairment (or not)...
October 12, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29020061/catching-up-children-with-developmental-coordination-disorder-compared-to-healthy-children-before-and-after-sensorimotor-therapy
#2
Mats Niklasson, Torsten Norlander, Irene Niklasson, Peder Rasmussen
The aims of the present study were to (a) compare healthy children in terms of sensorimotor maturity to untreated children diagnosed with developmental coordination disorder (DCD) and (b) compare healthy children to diagnosed children following completed treatment with sensorimotor therapy. Participants were 298 children, 196 boys and 102 girls, distributed into a Norm group of healthy children (n = 99) and a group of children diagnosed with DCD (n = 199) with a total mean age of 8.77 years (SD = 2.88). Participants in both groups were assessed on instruments aimed to detect sensorimotor deviations...
2017: PloS One
https://www.readbyqxmd.com/read/29018582/effect-of-low-dose-versus-higher-dose-antenatal-iron-supplementation-on-child-health-outcomes-at-36-months-of-age-in-viet-nam-longitudinal-follow-up-of-a-cluster-randomised-controlled-trial
#3
Sarah Hanieh, Tran T Ha, Julie A Simpson, Sabine Braat, Tran T Thuy, Thach D Tran, Janet King, Tran Tuan, Jane Fisher, Beverley-Ann Biggs
INTRODUCTION: Intermittent iron-folic acid supplementation (IFA) is currently recommended for pregnant women in populations where anaemia prevalence among pregnant women is <20% or if daily iron is not acceptable. The effect of providing lower doses of antenatal elemental iron through intermittent regimes on longer-term health outcomes in childhood is unclear. METHODS: A prospective cohort study conducted between May 2012 and May 2014 in Viet Nam among children of 36 months of age, born to women previously enrolled in a cluster randomised controlled trial of antenatal micronutrient supplementation (daily IFA (60 mg elemental iron) vs twice-weekly IFA (60 mg elemental iron) vs twice-weekly multiple micronutrient (MMN) supplementation (60 mg elemental iron))...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/28975039/creative-music-therapy-to-promote-brain-structure-function-and-neurobehavioral-outcomes-in-preterm-infants-a-randomized-controlled-pilot-trial-protocol
#4
Friederike Barbara Haslbeck, Hans-Ulrich Bucher, Dirk Bassler, Cornelia Hagmann
BACKGROUND: Preterm birth is associated with increased risk of neurological impairment and deficits in cognition, motor function, and behavioral problems. Limited studies indicate that multi-sensory experiences support brain development in preterm infants. Music appears to promote neurobiological processes and neuronal learning in the human brain. Creative music therapy (CMT) is an individualized, interactive therapeutic approach based on the theory and methods of Nordoff and Robbins...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28961316/reduced-infancy-and-childhood-epilepsy-following-hypothermia-treated-neonatal-encephalopathy
#5
Xun Liu, Sally Jary, Frances Cowan, Marianne Thoresen
OBJECTIVE: To investigate what proportion of a regional cohort of cooled infants with neonatal encephalopathy develop epilepsy (determined by the International League Against Epilepsy [ILAE] definition and the number of antiepileptic drugs [AEDs]) up to 8 years of age. METHODS: From 2006-2013, 151 infants with perinatal asphyxia underwent 72 h cooling. Clinical and amplitude-integrated electroencepalography (aEEG) with single-channel EEG-verified neonatal seizures were treated with AEDs...
September 29, 2017: Epilepsia
https://www.readbyqxmd.com/read/28957689/-the-effects-of-family-centered-physiotherapy-on-the-cognitive-and-motor-performance-in-premature-infants
#6
Bulent Elbasan, Murat Fatih Kocyigit, A Sebnem Soysal-Acar, Yıldız Atalay, Kivilcim Gucuyener
OBJECTIVE: The aim of this study is to investigate the effects of family centered physiotherapy according to the neurodevelopmental treatment (NDT) principles on mental and motor performance in premature infants. METHODS: A total of 156 infant, ≥24/36 week+6days gestational age included in the study. All the infants were diagnosed by a child neurologist and referred to psychology and physiotherapy department for their neurodevelopmental assessment and treatment...
September 25, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28950223/infant-motor-and-cognitive-abilities-and-subsequent-executive-function
#7
Meng Wu, Xi Liang, Shan Lu, Zhengyan Wang
INTRODUCTION: Although executive function (EF) is widely considered crucial to several aspects of life, the mechanisms underlying EF development remain largely unexplored, especially for infants. From a behavioral or neurodevelopmental perspective, motor and general cognitive abilities are linked with EF. EF development is a multistage process that starts with sensorimotor interactive behaviors, which become basic cognitive abilities and, in turn, mature EF. OBJECTIVES: This study aims to examine how infant motor and general cognitive abilities are linked with their EF at 3 years of age...
September 23, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28946866/the-effect-of-a-micronutrient-powder-home-fortification-program-on-anemia-and-cognitive-outcomes-among-young-children-in-rural-china-a-cluster-randomized-trial
#8
Renfu Luo, Ai Yue, Huan Zhou, Yaojiang Shi, Linxiu Zhang, Reynaldo Martorell, Alexis Medina, Scott Rozelle, Sean Sylvia
BACKGROUND: Anemia early in life has been associated with delayed cognitive and motor development. The WHO recommends home fortification using multiple micronutrient powders (MNPs) containing iron as a strategy to address anemia in children under two. We evaluated the effects of a program freely distributing MNP sachets to caregivers of infants in rural China. METHODS: We conducted a cluster-randomized controlled trial in Shaanxi province, enrolling all children aged 6-11 months in target villages...
September 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28946862/long-term-outcome-in-survivors-of-neonatal-tetanus-following-specialist-intensive-care-in-vietnam
#9
Huynh T Trieu, Nguyen Thi Kim Anh, Huynh Ngoc Thien Vuong, T T M Dao, Nguyen Thi Xuan Hoa, Vo Ngoc Cat Tuong, Pham Tam Dinh, Bridget Wills, Phan Tu Qui, Le Van Tan, Lam Minh Yen, Saraswathy Sabanathan, Catherine Louise Thwaites
BACKGROUND: Neonatal tetanus continues to occur in many resource-limited settings but there are few data regarding long-term neurological outcome from the disease, especially in settings with critical care facilities. METHODS: We assessed long-term outcome following neonatal tetanus in infants treated in a pediatric intensive care unit in southern Vietnam. Neurological and neurodevelopmental testing was performed in 17 survivors of neonatal tetanus and 18 control children from the same communities using tools previously validated in Vietnamese children...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28943715/methods-for-eliciting-annotating-and-analyzing-databases-for-child-speech-development
#10
Mary E Beckman, Andrew R Plummer, Benjamin Munson, Patrick F Reidy
Methods from automatic speech recognition (ASR), such as segmentation and forced alignment, have facilitated the rapid annotation and analysis of very large adult speech databases and databases of caregiver-infant interaction, enabling advances in speech science that were unimaginable just a few decades ago. This paper centers on two main problems that must be addressed in order to have analogous resources for developing and exploiting databases of young children's speech. The first problem is to understand and appreciate the differences between adult and child speech that cause ASR models developed for adult speech to fail when applied to child speech...
September 2017: Computer Speech & Language
https://www.readbyqxmd.com/read/28931039/abnormalities-in-substance-p-neurokinin-1-receptor-binding-in-key-brainstem-nuclei-in-sudden-infant-death-syndrome-related-to-prematurity-and-sex
#11
Fiona M Bright, Robert Vink, Roger W Byard, Jhodie R Duncan, Henry F Krous, David S Paterson
Sudden infant death syndrome (SIDS) involves failure of arousal to potentially life threatening events, including hypoxia, during sleep. While neuronal dysfunction and abnormalities in neurotransmitter systems within the medulla oblongata have been implicated, the specific pathways associated with autonomic and cardiorespiratory failure are unknown. The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the medulla, including regulation of respiratory rhythm generation, integration of cardiovascular control, and modulation of the baroreceptor reflex and mediation of the chemoreceptor reflex in response to hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28929094/gestational-age-dependent-increase-of-survival-motor-neuron-protein-in-umbilical-cord-derived-mesenchymal-stem-cells
#12
Sota Iwatani, Nur Imma Fatimah Harahap, Dian Kesumapramudya Nurputra, Shinya Tairaku, Akemi Shono, Daisuke Kurokawa, Keiji Yamana, Khin Kyae Mon Thwin, Makiko Yoshida, Masami Mizobuchi, Tsubasa Koda, Kazumichi Fujioka, Mariko Taniguchi-Ikeda, Hideto Yamada, Ichiro Morioka, Kazumoto Iijima, Hisahide Nishio, Noriyuki Nishimura
BACKGROUND: Spinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN) 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expressed and functionally linked to general RNA metabolism pathway, fibroblasts (FBs) are most widely used for the assessment of SMN expression in SMA patients but usually isolated from skin biopsy samples after the onset of overt symptoms...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28925580/nutrition-hygiene-and-stimulation-education-to-improve-growth-cognitive-language-and-motor-development-among-infants-in-uganda-a-cluster-randomized-trial
#13
Grace K M Muhoozi, Prudence Atukunda, Lien M Diep, Robert Mwadime, Archileo N Kaaya, Anne B Skaare, Tiril Willumsen, Ane C Westerberg, Per O Iversen
Stunting is associated with impaired cognitive and motor function. The effect of an education intervention including nutrition, stimulation, sanitation, and hygiene on child growth and cognitive/language/motor development, delivered to impoverished mothers in Uganda, was assessed. In a community-based, open cluster-randomized trial, 511 mother/children dyads aged 6-8 months were enrolled to an intervention (n = 263) or control (n = 248) group. The primary outcome was change in length-for-age z-score at age 20-24 months...
September 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28915773/does-motor-development-in-infancy-predict-spinal-pain-in-later-childhood-a-cohort-study
#14
Steven J Kamper, Christopher M Williams, Lise Hestbaek
Study Design Longitudinal cohort study. Background Spinal pain is responsible for a huge personal and societal burden, but its etiology remains unclear. Deficits in motor control have been associated with spinal pain in adults, and delayed motor development is associated with a range of health problems and risks in children. Objective To assess whether there is an independent relationship between the age at which infants first sit and walk without support and spinal pain at 11 years of age. Methods Data from the Danish National Birth Cohort were analyzed, using the age at which children first sat and first walked without support as predictors...
October 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28901887/microcytosis-is-associated-with-low-cognitive-outcomes-in-healthy-2-year-olds-in-a-high-resource-setting
#15
Elaine K McCarthy, Mairead E Kiely, Geraldine Hannon, Caroline Ahearne, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental outcomes in low risk, healthy 2-year-olds. This study was a secondary analysis of a nested case-control subgroup from the prospective, maternal-infant Cork Babies after Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints (BASELINE) Birth Cohort Study...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28891027/short-term-oral-zinc-supplementation-among-babies-with-neonatal-sepsis-for-reducing-mortality-and-improving-outcome-a-double-blind-randomized-controlled-trial
#16
Newton Banupriya, Ballambattu Vishnu Bhat, Bosco Dhas Benet, Christina Catherine, Magadi Gopalakrishna Sridhar, Subhash Chandra Parija
OBJECTIVE: To evaluate the efficacy of short term zinc supplementation on the mortality rate and neurodevelopment outcome in neonates with sepsis at 12 mo corrected age. METHODS: The clinical trial was undertaken in the neonatal intensive care unit of JIPMER during the time period from September 2013 through December 2016. Neonates with clinical manifestations of sepsis who exhibited two positive screening tests (microESR, C- reactive protein, band cell count) were included and randomized into no zinc and zinc group...
September 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28890690/a-cohesive-framework-for-motor-stereotypy-in-typical-and-atypical-development-the-role-of-sensorimotor-integration
#17
Robin L Shafer, Karl M Newell, Mark H Lewis, James W Bodfish
Stereotyped motor behavior manifests as rhythmic, repetitive movements. It is common in several neurologic and psychiatric disorders where it is considered maladaptive. However, it also occurs early in typical development where it serves an adaptive function in the development of complex, controlled motor behavior. Currently, no framework accounts for both adaptive and maladaptive forms of motor stereotypy. We propose a conceptual model that implicates sensorimotor mechanisms in the phenomenology of adaptive and maladaptive stereotypy...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28884620/nusinersen-for-the-treatment-of-spinal-muscular-atrophy
#18
Claudia A Chiriboga
Spinal muscular atrophy (SMA) is an autosomal recessive degenerative neuromuscular disorder characterized by loss of spinal motor neurons leading to muscle weakness. This review article focuses on a novel antisense oligonucleotide treatment, first ever approved for SMA (nusinersen, Spinraza(TM)) and describes the exciting journey from early ASO clinical trials to regulatory approval of the first ever known effective treatment for SMA. Areas covered: This article reviews the results of the published open label nusinersen studies in infants and children, and briefly covers the preliminary findings of the recently completed but as yet unpublished nusinersen-sham controlled trials, as well as the presymptomatic nusinersen trial known as Nurture...
October 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28878181/developmental-outcomes-at-24-months-of-age-in-toddlers-supplemented-with-arachidonic-acid-and-docosahexaenoic-acid-results-of-a-double-blind-randomized-controlled-trial
#19
Angela M Devlin, Cecil M Y Chau, Roger Dyer, Julie Matheson, Deanna McCarthy, Karin Yurko-Mauro, Sheila M Innis, Ruth E Grunau
Little is known about arachidonic acid (ARA) and docosahexaenoic acid (DHA) requirements in toddlers. A longitudinal, double blind, controlled trial in toddlers ( n = 133) age 13.4 ± 0.9 months (mean ± standard deviation), randomized to receive a DHA (200 mg/day) and ARA (200 mg/day) supplement (supplement) or a corn oil supplement (control) until age 24 months determined effects on neurodevelopment. We found no effect of the supplement on the Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) cognitive and language composites and Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI) at age 24 months...
September 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28877349/development-of-the-quality-of-reaching-in-infants-with-cerebral-palsy-a-kinematic-study
#20
Anke G Boxum, Sacha La Bastide-Van Gemert, Linze-Jaap Dijkstra, Elisa G Hamer, Tjitske Hielkema, Heleen A Reinders-Messelink, Mijna Hadders-Algra
AIM: To assess development of reaching and head stability in infants at very high risk (VHR-infants) of cerebral palsy (CP) who did and did not develop CP. METHOD: This explorative longitudinal study assessed the kinematics of reaching and head sway in sitting in 37 VHR-infants (18 CP) one to four times between 4.7 months and 22.6 months corrected age. Developmental trajectories were calculated using linear mixed effect models. Motor function was evaluated with the Infant Motor Profile (IMP) around 13 months corrected age...
September 6, 2017: Developmental Medicine and Child Neurology
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