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https://www.readbyqxmd.com/read/29454023/interaction-between-hypothermia-and-delayed-mesenchymal-stem-cell-therapy-in-neonatal-hypoxic-ischemic-brain-injury
#1
Josephine Herz, Christian Köster, Barbara S Reinboth, Mark Dzietko, Wiebke Hansen, Hemmen Sabir, Cindy van Velthoven, Ivo Bendix, Ursula Felderhoff-Müser
Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from long-lasting neurological impairments. Regenerative therapies, such as mesenchymal stem cells (MSC) appear promising as adjuvant therapy. In the present study, we hypothesized that HT combined with delayed MSC therapy results in augmented protection, improving long-term neurological outcome. Postnatal day 9 (P9) C57BL/6 mice were exposed to hypoxia-ischemia followed by 4 hours HT...
February 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29445839/vocalization-as-a-novel-endpoint-of-atypical-attachment-behavior-in-2-3-7-8-tetrachlorodibenzo-p-dioxin-exposed-infant-mice
#2
Eiki Kimura, Chiharu Tohyama
Mammalian attachment behaviors, such as crying, are essential for infant survival by receiving food, protection, and warmth from caregivers. Ultrasonic vocalization (USV) of infant rodents functions to promote maternal proximity. Impaired USV emission has been reported in mouse models of autism spectrum disorder, suggesting that USV is associated with higher brain function. In utero and lactational dioxin exposure is known to induce higher brain function abnormalities in adulthood; however, whether perinatal dioxin exposure affects behavior during infancy is unclear...
February 14, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29441034/reduced-mu-power-in-response-to-unusual-actions-is-context-dependent-in-1-year-olds
#3
Miriam Langeloh, David Buttelmann, Daniel Matthes, Susanne Grassmann, Sabina Pauen, Stefanie Hoehl
During social interactions infants predict and evaluate other people's actions. Previous behavioral research found that infants' imitation of others' actions depends on these evaluations and is context-dependent: 1-year-olds predominantly imitated an unusual action (turning on a lamp with one's forehead) when the model's hands were free compared to when the model's hands were occupied or restrained. In the present study, we adapted this behavioral paradigm to a neurophysiological study measuring infants' brain activity while observing usual and unusual actions via electroencephalography...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29429466/-recurrent-convulsion-and-pulmonary-infection-complicated-by-psychomotor-retardation-in-an-infant
#4
Juan Xiong, Jing Peng, Hao-Lin Duan, Chen Chen, Xiao-Le Wang, Shi-Meng Chen, Fei Yin
A 4-month-old girl developed convulsion in the neonatal period, which was focal motor seizures in the initial stage and later became spasm and tonic spasm. And the girl also had psychomotor retardation and recurrent pulmonary infection. Electroencephalography showed hypsarrhythmia, normal results were obtained from cranial magnetic resonance imaging, cerebrospinal fluid examination, and urine organic acid analysis, as well as the spectral analyses of blood ammonia, blood lactic acid, blood amino acids, and acylcarnitines...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29429197/-early-childhood-development-and-risk-factors-in-rural-china-a-cohort-study
#5
Y Cui, J Q Gao, A Yue, L Tang, R F Luo, Rozelle Scott
Objective: To investigate the development status and risk factors of infants and toddlers in rural China. Methods: In this cohort study, 603 infants (6-12 months of age, Phase Ⅰ) in the rural areas of QinLing-Bashan (Qin-Ba) in Shaanxi were recruited in the control group that received no intervention from April 2013 to October 2015. Three follow-up visits were performed every six months (Phase Ⅱ(12-18 months of age), Phase Ⅲ (18-24 months of age) and Phase Ⅳ(24-30 months of age)). In all the 4 phases (Ⅰ-Ⅳ), general data of the children and the families were collected by questionnaires, early childhood growth and development were assessed by door to door visits, children's hemoglobin levels were determined by laboratory tests, and the cognitive and motor development screening was conducted by the Bayley Scales of Infant and Toddler Development...
February 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29426320/supporting-play-exploration-and-early-developmental-intervention-versus-usual-care-to-enhance-development-outcomes-during-the-transition-from-the-neonatal-intensive-care-unit-to-home-a-pilot-randomized-controlled-trial
#6
Stacey C Dusing, Tanya Tripathi, Emily C Marcinowski, Leroy R Thacker, Lisa F Brown, Karen D Hendricks-Muñoz
BACKGROUND: While therapy services may start in the Neonatal Intensive Care Unit (NICU) there is often a gap in therapy after discharge. Supporting Play Exploration and Early Development Intervention (SPEEDI) supports parents, helping them build capacity to provide developmentally supportive opportunities starting in the NICU and continuing at home. The purpose of this single blinded randomized pilot clinical trial was to evaluate the initial efficacy of SPEEDI to improve early reaching and exploratory problem solving behaviors...
February 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29416504/electrophysiological-and-morphological-properties-of-%C3%AE-and-%C3%AE-motoneurons-in-the-rat-trigeminal-motor-nucleus
#7
Kayo Nishimura, Masahiro Ohta, Mitsuru Saito, Yukako Morita-Isogai, Hajime Sato, Eriko Kuramoto, Dong Xu Yin, Yoshinobu Maeda, Takeshi Kaneko, Takashi Yamashiro, Kenji Takada, Seog Bae Oh, Hiroki Toyoda, Youngnam Kang
The muscle contraction during voluntary movement is regulated by activities of α- and γ-motoneurons (αMNs and γMNs, respectively). The tension of jaw-closing muscles can be finely tuned over a wide range. This excellent function is likely to be achieved by the specific populations of αMNs innervating jaw-closing muscles. Indeed, we have recently demonstrated that in the rat dorsolateral trigeminal motor nucleus (dl-TMN), the size distribution of αMNs was bimodal and the population of smaller αMNs showed a size distribution similar to that of γMNs, by immunohistochemically identifying αMNs and γMNs based on the expressions of estrogen-related receptor gamma (Err3) and neuronal DNA binding protein NeuN together with ChAT...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29409959/ahr-and-cyp1a2-genotypes-both-affect-susceptibility-to-motor-deficits-following-gestational-and-lactational-exposure-to-polychlorinated-biphenyls
#8
Breann T Colter, Helen Frances Garber, Sheila M Fleming, Jocelyn Phillips Fowler, Gregory D Harding, Molly Kromme Hooven, Amy Ashworth Howes, Smitha Krishnan Infante, Anna L Lang, Melinda Curran MacDougall, Melinda Stegman, Kelsey Rae Taylor, Christine Perdan Curran
Polychlorinated biphenyls (PCBs) are persistent organic pollutants known to cause adverse health effects and linked to neurological deficits in both human and animal studies. Children born to exposed mothers are at highest risk of learning and memory and motor deficits. We developed a mouse model that mimics human variation in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) to determine if genetic variation increases susceptibility to developmental PCB exposure. In our previous studies, we found that high-affinity AhrbCyp1a2(-/-) and poor-affinity AhrdCyp1a2(-/-) knockout mice were most susceptible to learning and memory deficits following developmental PCB exposure compared with AhrbCyp1a2(+/+) wild type mice (C57BL/6J strain)...
January 30, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29407430/identifying-the-level-of-trunk-control-of-healthy-term-infants-aged-from-6-to-9-months
#9
Ana Luiza Righetto Greco, Carolina Souza Neves da Costa, Eloisa Tudella
This study identified the level of trunk control of healthy term infants aged from six to nine months. This cross-sectional study included fifty-five infants aged from six to nine months. The levels of trunk control was investigated by using the Segmental Assessment Trunk Control (SATCo). The infants remained seated on a wooden bench and a neutral pelvic position was maintained. The SATCo score was considered as dependent variable. The results showed that infants aged six and seven months presented levels of trunk control in the thoracic region while infants aged from eight to nine months presented full trunk control...
February 5, 2018: Infant Behavior & Development
https://www.readbyqxmd.com/read/29399949/adaptive-behavior-in-infants-and-toddlers-with-down-syndrome-and-fragile-x-syndrome
#10
Elizabeth A Will, Kelly E Caravella, Laura J Hahn, Deborah J Fidler, Jane E Roberts
Individuals with Down syndrome (DS) experience deficits across all domains of adaptive functioning, however little is known about the emergence and age-related changes of these impairments compared to other neurogenetic disorders with similar intellectual disability impairments, such as fragile X syndrome (FXS). Adaptive behavior is key for optimal functioning in these populations. Participants aged 5-45 months comprised three age-matched groups, DS (n = 64), FXS (n = 69), and typically developing controls (TD; n = 69)...
February 5, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29390342/the-predictive-value-of-early-oral-motor-assessments-for-neurodevelopmental-outcomes-of-moderately-and-late-preterm-infants
#11
Xianhong Zhang, Mei Zhou, Huaying Yin, Ying Dai, Yuwei Li
Oral motor assessment is used to identify abnormal sucking patterns which may reflect neurodevelopmental problems in preterm infants, but few studies have focused on moderately and late preterm infants. We enrolled 118 moderately and late preterm infants (mean gestational age, 35.04 weeks; mean birth weight, 2347.59 g) and analyzed the relationship between the Neonatal Oral-Motor Assessment Scale scores of these infants and the Chinese revision of Bayley Scales of Infant Development outcomes at 6 months corrected age...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388051/cognitive-development-of-toddlers-does-parental-stimulation-matter
#12
Prahbhjot Malhi, Jagadeesh Menon, Bhavneet Bharti, Manjit Sidhu
OBJECTIVE: To examine the impact of quality of early stimulation on cognitive functioning of toddlers living in a developing country. METHODS: The developmental functioning of 150 toddlers in the age range of 12-30 mo (53% boys; Mean = 1.76 y, SD = 0.48) was assessed by the mental developmental index of the Developmental Assessment Scale for Indian Infants (DASII). The StimQ questionnaire- toddler version was used to measure cognitive stimulation at home...
February 1, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29374109/neurodevelopment-in-young-children-born-to-hiv-infected-mothers-a-meta-analysis
#13
REVIEW
Megan S McHenry, Carole I McAteer, Eren Oyungu, Brenna C McDonald, Chris B Bosma, Philani B Mpofu, Andrew R Deathe, Rachel C Vreeman
CONTEXT: HIV-infected (HIV+) children have worse neurodevelopmental outcomes compared with HIV-uninfected children. However, little is known regarding the differences in neurodevelopment between young HIV+ children, HIV-exposed but uninfected (HEU) children, and HIV-unexposed and uninfected (HUU) children. OBJECTIVE: To systematically review and meta-analyze data on neurodevelopmental performance between young HIV+, HEU, and HUU children. DATA SOURCES: We systematically searched the following electronic bibliographic databases: Ovid Medline, Embase, PsycINFO, Education Resources Information Center, and the Cochrane Database of Systematic Reviews...
January 26, 2018: Pediatrics
https://www.readbyqxmd.com/read/29360435/cerebellar-oxidative-stress-and-fine-motor-impairment-in-adolescent-rats-exposed-to-hyperthermia-induced-seizures-is-prevented-by-maternal-caffeine-intake-during-gestation-and-lactation
#14
María Crespo, David Agustín León-Navarro, Mairena Martín
Febrile seizures (FS) is one of the most common convulsive disorders in infants and young children that only occurs during the first years of life in humans, when the cerebellum is still developing. Several works have shown that maternal caffeine consumption during gestation and lactation can exert protective effects on developing brain under pathological conditions. Here, we have used an animal model of FS to know whether maternal caffeine consumption during gestation and lactation exhibited protective effects on rat cerebellum...
January 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29357477/emergent-coordination-underlying-learning-to-reach-to-grasp-with-a-brain-machine-interface
#15
Mukta Vaidya, Karthikeyan Balasubramanian, Joshua Southerland, Islam Badreldin, Ahmed Eleryan, Kelsey Shattuck, Suchin Gururangan, Marc W Slutzky, Leslie C Osborne, Andrew H Fagg, Karim G Oweiss, Nicholas G Hatsopoulos
The development of coordinated reach to grasp has been well-studied in infants and children (Kuhtz-Buschbeck, Stolze, Jöhnk, Boczek-Funcke, & Illert, 1998; von Hofsten, 1984a). However, the role of motor cortex during this development is unclear because it is difficult to study in humans. We took the approach using a brain-machine interface (BMI) paradigm in rhesus macaques with prior therapeutic amputations to examine the emergence of novel, coordinated reach-to-grasp. Previous research has shown that after amputation, the cortical area previously involved in the control of the lost limb undergoes reorganization (Qi, Stepniewska, & Kaas, 2000; Schieber & Deuel, 1997; Wu & Kaas, 1999), but prior BMI work has largely relied on finding neurons that already encode specific movement-related information...
December 13, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29356073/national-population-based-cohort-study-found-that-visual-motor-integration-was-commonly-affected-in-extremely-preterm-born-children-at-6-5-years
#16
Jenny Bolk, Ylva Fredriksson Kaul, Lena Hellström-Westas, Karin Stjernqvist, Nelly Padilla, Fredrik Serenius, Kerstin Hellgren, Ulrika Åden
AIM: This study aimed to explain the relationship between visual-motor integration abilities and extremely preterm birth, by exploring the influence of perinatal variables, cognition, manual dexterity and ophthalmological outcomes. METHODS: This was part of the population-based national Extremely Preterm Infant Study in Sweden (EXPRESS) study. We studied 355 children, born at a gestational age of less than 27 weeks from April 2004 to March 2007, and 364 term-born controls...
January 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29354937/-therapeutic-effects-on-cerebral-white-matter-injury-of-premature-infants-treated-with-acupuncture-for-promoting-the-governor-vessel-and-tranquilizing-the-mind
#17
Shuying Cai, Zhenhuan Liu, Guilan Peng, Xinfa Huang, Yinlan Li, Shuxiang Hu
OBJECTIVE: To explore the repair effects of acupuncture for promoting the governor vessel and tranquilizing the mind (acupuncture technique) on cerebral white matter injury of premature infants. METHODS: A total of 56 cases of cerebral whiter matter injury of premature infants, the fetal age less than 35 weeks were selected and randomized into an observation group (27 cases) and a control group (29 cases). The routine basic rehabilitation therapy was used in the two groups...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29349922/association-between-breast-milk-intake-at-9-10%C3%A2-months-of-age-and-growth-and-development-among-malawian-young-children
#18
Chiza Kumwenda, Jaimie Hemsworth, John Phuka, Ulla Ashorn, Mary Arimond, Kenneth Maleta, Elizabeth L Prado, Marjorie J Haskell, Kathryn G Dewey, Per Ashorn
World Health Organization recommends exclusive breastfeeding for infants for the first 6 months of life, followed by introduction of nutritious complementary foods alongside breastfeeding. Breast milk remains a significant source of nourishment in the second half of infancy and beyond; however, it is not clear whether more breast milk is always better. The present study was designed to determine the association between amount of breast milk intake at 9-10 months of age and infant growth and development by 12-18 months of age...
January 19, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29349505/embracing-your-emotions-affective-state-impacts-lateralisation-of-human-embraces
#19
Julian Packheiser, Noemi Rook, Zeynep Dursun, Janne Mesenhöller, Alrescha Wenglorz, Onur Güntürkün, Sebastian Ocklenburg
Humans are highly social animals that show a wide variety of verbal and non-verbal behaviours to communicate social intent. One of the most frequently used non-verbal social behaviours is embracing, commonly used as an expression of love and affection. However, it can also occur in a large variety of social situations entailing negative (fear or sadness) or neutral emotionality (formal greetings). Embracing is also experienced from birth onwards in mother-infant interactions and is thus accompanying human social interaction across the whole lifespan...
January 18, 2018: Psychological Research
https://www.readbyqxmd.com/read/29346141/caffeine-controversies
#20
Samuel J Gentle, Colm P Travers, Waldemar A Carlo
PURPOSE OF REVIEW: Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction. The purpose of the review is to analyze this dynamic trajectory and discuss controversies that still remain after decades of caffeine use. RECENT FINDINGS: Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus...
January 17, 2018: Current Opinion in Pediatrics
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