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Infant motor profile

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https://www.readbyqxmd.com/read/27882347/ml372-blocks-smn-ubiquitination-and-improves-spinal-muscular-atrophy-pathology-in-mice
#1
Mahlet B Abera, Jingbo Xiao, Jonathan Nofziger, Steve Titus, Noel Southall, Wei Zheng, Kasey E Moritz, Marc Ferrer, Jonathan J Cherry, Elliot J Androphy, Amy Wang, Xin Xu, Christopher Austin, Kenneth H Fischbeck, Juan J Marugan, Barrington G Burnett
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and one of the leading inherited causes of infant mortality. SMA results from insufficient levels of the survival motor neuron (SMN) protein, and studies in animal models of the disease have shown that increasing SMN protein levels ameliorates the disease phenotype. Our group previously identified and optimized a new series of small molecules, with good potency and toxicity profiles and reasonable pharmacokinetics, that were able to increase SMN protein levels in SMA patient-derived cells...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27865525/maternal-stress-modifies-the-effect-of-exposure-to-lead-during-pregnancy-and-24-month-old-children-s-neurodevelopment
#2
Marcela Tamayo Y Ortiz, Martha María Téllez-Rojo, Belem Trejo-Valdivia, Lourdes Schnaas, Erika Osorio-Valencia, Brent Coull, David Bellinger, Rosalind J Wright, Robert O Wright
BACKGROUND: Lead and psychosocial stress disrupt similar but not completely overlapping mechanisms. Exposure during the prenatal period to each of these insults singularly has been found to alter normal neurodevelopment; however, longitudinal associations with stress modifying the effect of lead have not been sufficiently analyzed in epidemiologic studies. OBJECTIVE: To evaluate prenatal stress as an effect modifier of gestational lead neurotoxicity. METHODS: We used a structural equations modeling approach with a trivariate response to evaluate cognitive, language and motor scores of the Bayley Scales of Infant Development-III in 24month-old children (n=360)...
November 16, 2016: Environment International
https://www.readbyqxmd.com/read/27854230/developmental-milestones-and-quality-of-life-assessment-in-a-congenital-myotonic-dystrophy-cohort
#3
Madhavi Prasad, Rhiannon Hicks, Melissa MacKay, Cam-Tu Nguyen, Craig Campbell
BACKGROUND: Congenital myotonic dystrophy (CDM) is a neuromuscular disorder caused by a CTG triplet repeat expansion in the DMPK gene. In addition to the expected motor delay, affected children often have significant developmental disability in language and cognitive realms, which ultimately impacts on quality of life. OBJECTIVE: In a prospective cohort of children with CDM to 1) present the profile of language and motor developmental milestones, and 2) describe their early childhood health related quality of life (HRQOL)...
August 30, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27830264/an-exploration-of-the-use-of-eye-gaze-and-gestures-in-females-with-rett-syndrome
#4
Anna Urbanowicz, Jenny Downs, Sonya Girdler, Natalie Ciccone, Helen Leonard
Purpose: This study investigated the communicative use of eye gaze and gestures in females with Rett syndrome. Method: Data on 151 females with Rett syndrome participating in the Australian Rett Syndrome Database was used in this study. Items from the Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist (Wetherby & Prizant, 2002) were used to measure communication. Relationships between the use of eye gaze and gestures for communication were investigated using logistic regression...
November 8, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27826251/immature-spinal-locomotor-output-in-children-with-cerebral-palsy
#5
Germana Cappellini, Yury P Ivanenko, Giovanni Martino, Michael J MacLellan, Annalisa Sacco, Daniela Morelli, Francesco Lacquaniti
Detailed descriptions of gait impairments have been reported in cerebral palsy (CP), but it is still unclear how maturation of the spinal motoneuron output is affected. Spatiotemporal alpha-motoneuron activation during walking can be assessed by mapping the electromyographic activity profiles from several, simultaneously recorded muscles onto the anatomical rostrocaudal location of the motoneuron pools in the spinal cord, and by means of factor analysis of the muscle activity profiles. Here, we analyzed gait kinematics and EMG activity of 11 pairs of bilateral muscles with lumbosacral innervation in 35 children with CP (19 diplegic, 16 hemiplegic, 2-12 years) and 33 typically developing (TD) children (1-12 years)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27667762/brain-metabolite-alterations-in-infants-born-preterm-with-intrauterine-growth-restriction-association-with-structural-changes-and-neurodevelopmental-outcome
#6
Rui V Simões, Emma Muñoz-Moreno, Mónica Cruz-Lemini, Elisenda Eixarch, Núria Bargalló, Magdalena Sanz-Cortes, Eduard Gratacós
BACKGROUND: Intrauterine growth restriction (IUGR) and premature birth represent two independent problems that may occur simultaneously, and contribute to impaired neurodevelopment. OBJECTIVE: To assess changes in frontal lobe metabolic profiles of one-year-old IUGR infants born prematurely (P-IUGR) and adequate for gestational age controls, both premature (P-AGA) and born at term (T-AGA), and their association with brain structural and biophysical parameters, and neurodevelopmental outcome at two years...
September 22, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27591975/relationship-between-brain-lesion-characteristics-and-communication-in-preschool-children-with-cerebral-palsy
#7
Andrea Coleman, Simona Fiori, Kelly A Weir, Robert S Ware, Roslyn N Boyd
BACKGROUND: MRI shows promise as a prognostic tool for clinical findings such as gross motor function in children with cerebral palsy(CP), however the relationship with communication skills requires exploration. AIMS: To examine the relationship between the type and severity of brain lesion on MRI and communication skills in children with CP. METHODS AND PROCEDURES: 131 children with CP (73 males(56%)), mean corrected age(SD) 28(5) months, Gross Motor Functional Classification System distribution: I=57(44%), II=14(11%), III=19(14%), IV=17(13%), V=24(18%)...
November 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27579313/dha-and-epa-content-and-fatty-acid-profile-of-39-food-fishes-from-india
#8
Bimal Prasanna Mohanty, Satabdi Ganguly, Arabinda Mahanty, T V Sankar, R Anandan, Kajal Chakraborty, B N Paul, Debajit Sarma, J Syama Dayal, G Venkateshwarlu, Suseela Mathew, K K Asha, D Karunakaran, Tandrima Mitra, Soumen Chanda, Neetu Shahi, Puspita Das, Partha Das, Md Shahbaz Akhtar, P Vijayagopal, N Sridhar
Docosahexaenoic acid (DHA) is the principal constituent of a variety of cells especially the brain neurons and retinal cells and plays important role in fetal brain development, development of motor skills, and visual acuity in infants, lipid metabolism, and cognitive support and along with eicosapentaenoic acid (EPA) it plays important role in preventing atherosclerosis, dementia, rheumatoid arthritis, Alzheimer's disease, and so forth. Being an essential nutrient, it is to be obtained through diet and therefore searching for affordable sources of these ω-3 polyunsaturated fatty acids (PUFA) is important for consumer guidance and dietary counseling...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27548865/effectiveness-of-a-sensory-enriched-early-intervention-group-program-for-children-with-developmental-disabilities
#9
Erna Imperatore Blanche, Megan C Chang, Juliana Gutiérrez, Janet S Gunter
OBJECTIVE: The study's objective was to evaluate the effectiveness of the Interdisciplinary Sensory-Enriched Early Intervention (ISEEI) group program for children with developmental delays. METHOD: We conducted a retrospective chart review of 63 children ages 18-36 mo who participated in ISEEI. We evaluated participants with the Bayley Scales of Infant and Toddler Development III (Bayley-III) and the Infant/Toddler Sensory Profile (ITSP) at enrollment and after 3-9 mo...
September 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/27475922/neurophysiological-profile-of-peripheral-neuropathy-associated-with-childhood-mitochondrial-disease
#10
Manoj P Menezes, Shamima Rahman, Kaustuv Bhattacharya, Damian Clark, John Christodoulou, Carolyn Ellaway, Michelle Farrar, Matthew Pitt, Hugo Sampaio, Tyson L Ware, Yehani Wedatilake, David R Thorburn, Monique M Ryan, Robert Ouvrier
INTRODUCTION: Peripheral nerve involvement is common in mitochondrial disease but often unrecognised due to the prominent central nervous system features. Identification of the underlying neuropathy may assist syndrome classification, targeted genetic testing and rehabilitative interventions. METHODS: Clinical data and the results of nerve conduction studies were obtained retrospectively from the records of four tertiary children's hospital metabolic disease, neuromuscular or neurophysiology services...
September 2016: Mitochondrion
https://www.readbyqxmd.com/read/27468114/slow-pupillary-light-responses-in-infants-at-high-risk-of-cerebral-palsy-were-associated-with-periventricular-leukomalacia-and-neurological-outcome
#11
Elisa G Hamer, R Jeroen Vermeulen, Linze J Dijkstra, Tjitske Hielkema, Claire Kos, Arend F Bos, Mijna Hadders-Algra
AIM: Having observed slow pupillary light responses (PLRs) in infants at high risk of cerebral palsy, we retrospectively evaluated whether these were associated with specific brain lesions or unfavourable outcomes. METHODS: We carried out neurological examinations on 30 infants at very high risk of cerebral palsy five times until the corrected age of 21 months, classifying each PLR assessment as normal or slow. The predominant reaction during development was determined for each infant...
December 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27405056/predictive-role-of-early-milestones-related-psychomotor-profiles-and-long-term-neurodevelopmental-pitfalls-in-preterm-infants
#12
Gabriella Di Rosa, Tiziana Cavallaro, Angela Alibrandi, Lucia Marseglia, Marco Lamberti, Elisa Giaimo, Antonio Nicotera, Maria Bonsignore, Antonella Gagliano
BACKGROUND: Developmental milestones are useful signposts developed to assess the pace and the trajectory of maturation occurring during specific time-windows called critical periods. The predictive role of their clinical assessment in premature infants is challenging, however, it actually represents an easy and reliable tool at follow-up. AIM AND STUDY DESIGN: Relying on a milestone-based neurological examination, we aimed to detect the interdependence between time of achievement of each milestone with long-term neuropsychological and neurodevelopmental outcomes...
October 2016: Early Human Development
https://www.readbyqxmd.com/read/27380594/probiotics-for-the-management-of-infantile-colic
#13
Hania Szajewska, Radosław Dryl
PURPOSE OF REVIEW: Evidence suggests that the gut microbiota in subjects with infantile colic differs from the gut microbiota in an unaffected population. In colicky infants, dysbiosis may affect gut motor function and gas production resulting in abdominal pain/colic. If so, it is logical to assume that manipulation of the gut microbiota may play a therapeutic role and also could be a preventive measure in the evolution of these disorders. We aimed to evaluate evidence on the effectiveness of probiotics for treating and preventing infantile colic...
July 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27242630/performance-of-motor-sequences-in-children-at-heightened-vs-low-risk-for-asd-a-longitudinal-study-from-18-to-36-months-of-age
#14
Valentina Focaroli, Fabrizio Taffoni, Shelby M Parsons, Flavio Keller, Jana M Iverson
Recent research shows that motor difficulties are a prominent component of the behavioral profile of autism spectrum disorder (ASD) and are also apparent from early in development in infants who have an older sibling with ASD (High Risk; HR). Delays have been reported for HR infants who do and who do not receive an eventual diagnosis of ASD. A growing body of prospective studies has focused on the emergence of early motor skills primarily during the first year of life. To date, however, relatively little work has examined motor skills in the second and third years...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27074125/the-motor-profile-of-preterm-infants-at-11-y-of-age
#15
Sirkku Setänen, Liisa Lehtonen, Riitta Parkkola, Jaakko Matomäki, Leena Haataja
BACKGROUND: Preterm infants are at a higher risk for poor motor outcome than term infants. This study aimed to describe the long-term motor profile in very preterm born children. METHODS: A total of 98 very preterm infants were included. Volumetric brain magnetic resonance imaging (MRI) was performed at term age, and the Movement Assessment Battery for Children-Second Edition (The Movement ABC-2) was employed at 11 y of age. The diagnosis of Developmental Coordination Disorder (DCD) was determined at 11 y of age according to the International Classification of Diseases...
September 2016: Pediatric Research
https://www.readbyqxmd.com/read/27023142/commentary-on-inter-and-intrarater-reliability-of-the-infant-motor-profile-in-3-to-18-month-old-infants
#16
COMMENT
Rian Eijsermans, Jacqueline Nuysink
No abstract text is available yet for this article.
2016: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/27008092/does-embryo-culture-medium-influence-the-health-and-development-of-children-born-after-in-vitro-fertilization
#17
Céline Bouillon, Roger Léandri, Laurent Desch, Alexandra Ernst, Céline Bruno, Charline Cerf, Alexandra Chiron, Céline Souchay, Antoine Burguet, Clément Jimenez, Paul Sagot, Patricia Fauque
In animal studies, extensive data revealed the influence of culture medium on embryonic development, foetal growth and the behaviour of offspring. However, this impact has never been investigated in humans. For the first time, we investigated in depth the effects of embryo culture media on health, growth and development of infants conceived by In Vitro Fertilization until the age of 5 years old. This single-centre cohort study was based on an earlier randomized study. During six months, in vitro fertilization attempts (No...
2016: PloS One
https://www.readbyqxmd.com/read/26968833/multimodal-outcome-at-7-years-of-age-after-neonatal-arterial-ischemic%C3%A2-stroke
#18
Stéphane Chabrier, Emeline Peyric, Laure Drutel, Johanna Deron, Manoëlle Kossorotoff, Mickaël Dinomais, Leila Lazaro, Jérémie Lefranc, Guillaume Thébault, Gérard Dray, Joel Fluss, Cyrille Renaud, Sylvie Nguyen The Tich
OBJECTIVES: To evaluate the epileptic, academic, and developmental status at age 7 years in a large population of term-born children who sustained neonatal arterial ischemic stroke (NAIS), and to assess the co-occurrence of these outcomes. STUDY DESIGN: A cohort study including 100 term newborns with NAIS was designed. Two infants died during the neonatal period, 13 families were lost to follow-up, and 5 families declined to participate in this evaluation. Thus, 80 families completed the 7-year clinical assessment...
May 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26955913/does-early-communication-mediate-the-relationship-between-motor-ability-and-social-function-in-children-with-cerebral-palsy
#19
Belinda Lipscombe, Roslyn N Boyd, Andrea Coleman, Michael Fahey, Barry Rawicki, Koa Whittingham
BACKGROUND: Children diagnosed with neurodevelopmental conditions such as cerebral palsy (CP) are at risk of experiencing restrictions in social activities negatively impacting their subsequent social functioning. Research has identified motor and communication ability as being unique determinants of social function capabilities in children with CP, to date, no research has investigated whether communication is a mediator of the relationship between motor ability and social functioning...
June 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/26901537/inter-and-intrarater-reliability-of-the-infant-motor-profile-in-3-to-18-month-old-infants
#20
Eva Hecker, Gillian D Baer, Christina Stark, Peter Herkenrath, Mijna Hadders-Algra
PURPOSE: To investigate inter- and intrarater reliability scoring the Infant Motor Profile (IMP). METHODS: A total of 20 infants at risk for motor developmental delay were assessed using the IMP. Six infants were born at term (gestational age: 38-42 weeks), and 14 infants were preterm (gestational age: 24-35 weeks). Videos were analyzed twice with an interval of 1 month by 4 assessors after 2 days of IMP training. RESULTS: Spearman rank scores demonstrated strong interrater and intrarater reliability for total IMP scores (inter: r = 0...
2016: Pediatric Physical Therapy
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