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gastric signet cell

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https://www.readbyqxmd.com/read/28418918/the-pd-1-pd-l1-expression-and-cd3-t-cell-infiltration-in-relation-to-outcome-in-advanced-gastric-signet-ring-cell-carcinoma-representing-a-potential-biomarker-for-immunotherapy
#1
Shenying Jin, Bo Xu, Lixia Yu, Yao Fu, Hongyan Wu, Xiangshan Fan, Jia Wei, Baorui Liu
Recent data supports a potentially significant role for immune checkpoint inhibitors in the treatment of gastric cancer. However, there are few data on the clinical implications of immunotherapy markers in gastric signet-ring cell carcinoma (SRCC). We evaluated the expression of programmed cell death protein-1 (PD-1), programmed cell death ligand 1(PD-L1), infiltration by CD3+ T cell, microsatellite instability (MSI), and Epstein-Barr Virus (EBV), and the relationship of each factor to survival in 89 advanced SRCC patients...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416355/expression-of-coproporphyrinogen-oxidase-is-associated-with-detection-of-upper-gastrointestinal-carcinomas-by-5-aminolevulinic-acid-mediated-photodynamic-diagnosis
#2
Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao
BACKGROUND: 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer...
April 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28405535/signet-cell-in-the-brain-a-case-report-of-leptomeningeal-carcinomatosis-as-the-presenting-feature-of-gastric-signet-cell-cancer
#3
Saeed Ali, Muhammad Talha Khan, Evgeny A Idrisov, Aadil Maqsood, Fnu Asad-Ur-Rahman, Khalid Abusaada
Malignant infiltration of pia and arachnoid mater, referred to as leptomeningeal carcinomatosis (LMC), is a rare complication of gastric carcinoma. The most common underlying malignancy in patients with LMC are leukemia, breast cancer, lymphoma, and lung cancer. We report a case of gastric adenocarcinoma that presented with LMC in the absence of overt gastrointestinal signs or symptoms. A 56-year-old Hispanic woman presented to the hospital with a three-week history of intermittent headaches and visual blurring...
March 7, 2017: Curēus
https://www.readbyqxmd.com/read/28405154/breast-cancer-metastasizing-to-the-stomach-mimicking-primary-gastric-cancer-a-case-report
#4
Kwangil Yim, Sang Mi Ro, Jieun Lee
Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach...
March 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28373777/dynamic-enhanced-computed-tomography-imaging-findings-of-an-inflammatory-fibroid-polyp-with-massive-fibrosis-in-the-stomach
#5
Eun Jung Shim, Sung Eun Ahn, Dong Ho Lee, Seong Jin Park, Youn Wha Kim
Inflammatory fibroid polyp (IFP) is a rare benign lesion of the gastrointestinal tract. We report a case of computed tomography (CT) imaging finding of a gastric IFP with massive fibrosis. CT scans showed thickening of submucosal layer with overlying mucosal hyperenhancement in the gastric antrum. The submucosal layer showed increased enhancement on delayed phase imaging. An antrectomy with gastroduodenostomy was performed because gastric cancer was suspected, particularly signet ring cell carcinoma. The histopathological diagnosis was an IFP with massive fibrosis...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28331875/a-novel-endoscopic-technique-to-diagnose-gastric-cancer-in-excluded-stomach-after-roux-en-y-gastric-bypass
#6
Rashmi Kumar, Teodor C Pitea
Access to the bypassed portion of the stomach after Roux-en-Y gastric bypass remains a challenge. We present a case of 64-year-old woman who presented with gastric outlet obstruction. We used a novel endoscopic technique to access the bypassed stomach by creating a jejunogastrostomy using a specialized stent, which allowed the insertion of a pediatric gastroscope to examine the bypassed portion of the stomach. Stomach biopsies revealed poorly differentiated adenocarcinoma with signet cell features.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28326183/signet-ring-cells-in-the-skin-a-case-of-late-onset-cutaneous-metastasis-of-gastric-carcinoma-and-a-brief-review-of-histological-approach
#7
Özgür Gündüz, Mehmet Can Emeksiz, Pinar Atasoy, Mehtap Kidir, Selim Yalçin, Serkan Demirkan
Up to 10% of patients with visceral malignancies develop skin metastases during their clinical course and these metastases constitute about 2% of all skin cancers. Skin metastasis may be the first sign of a clinically silent visceral cancer or represent recurrence of an internal malignancy. In both situations, they are associated with poor prognosis, which can partly be attributed to underdiagnosis. In this paper, a case of relapsing gastric adenocarcinoma, which manifested itself as asymptomatic cutaneous papules and nodules on a patient's head and neck, is reported and histopathological approach to the cutaneous lesions containing signet-ring cell is briefly reviewed...
June 15, 2016: Dermatology Reports
https://www.readbyqxmd.com/read/28317588/applicability-of-endoscopic-submucosal-dissection-for-undifferentiated-early-gastric-cancer-mixed-histology-of-poorly-differentiated-adenocarcinoma-and-signet-ring-cell-carcinoma-is-a-worse-predictive-factor-of-nodal-metastasis
#8
In Seob Lee, Sol Lee, Young Soo Park, Chung Sik Gong, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) is not considered an appropriate treatment for undifferentiated early gastric cancer (UEGC) due to the higher risk of nodal metastases. We aimed to investigate predictive factors for nodal metastases in UEGCs, determine whether the tumor histology is an independent factor for it, and explore whether ESD is applicable for UEGC. METHODS: We reviewed the medical records of 1837 patients who underwent curative gastrectomy for poorly differentiated adenocarcinoma, signet ring cell carcinoma, and a mixed type of both tumors between 2008 and 2012...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28256061/intraoperative-peritoneal-lavage-cytology-offers-prognostic-significance-for-gastric-cancer-patients-with-curative-resection
#9
Eiji Higaki, Shinya Yanagi, Naoto Gotohda, Takahiro Kinoshita, Takeshi Kuwata, Masato Nagino, Atsushi Ochiai, Satoshi Fujii
Outcomes of patients with gastric cancer who exhibit positive peritoneal lavage cytology findings (CY(+) ) vary by diagnostic methods because of quantitative and qualitative cancer cell diversity. This study sought to establish practical diagnostic criteria for performing curative resections, based on peritoneal lavage cytology findings in gastric cancer patients. We enrolled 1028 patients with gastric cancer who underwent R0/1 (n=911) or R2 (n=117) resections and analyzed relationships between cancer cell findings in peritoneal lavage fluid and clinicopathological factors in the R0/1 group...
March 3, 2017: Cancer Science
https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#10
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28194592/the-yield-of-staging-laparoscopy-in-gastric-cancer-is-affected-by-racial-and-ethnic-differences-in-disease-presentation
#11
Ibrahim Nassour, Hannah Fullington, Linda S Hynan, Adam C Yopp, Mathew M Augustine, Patricio M Polanco, Michael A Choti, John C Mansour, Sam C Wang, Matthew R Porembka
BACKGROUND: Gastric cancer is a heterogeneous disease with variable presentation between racial and ethnic groups. Staging laparoscopy (SL) detects occult metastases not visible on cross-sectional imaging and therefore improves staging. It remains unclear how differences in race and ethnicity affect disease presentation and the yield of SL. METHODS: We performed a retrospective review of a prospectively maintained database to identify patients with gastric cancer treated with curative intent at our institutions from 2008 to 2015...
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28178894/adenocarcinoma-of-the-lung-metastatic-to-the-ovary-with-a-signet-ring-cell-component
#12
Giovanna Giordano, Nelly Cruz Viruel, Enrico Maria Silini, Francisco F Nogales
A nonsmoker 45-year-old woman, presented with a solid right ovarian mass. Microscopic examination revealed heterogeneous histology with tubular formations and extensive signet ring cell component that resembled the usual appearance of metastatic gastric carcinoma to the ovary. Moreover, the histology also showed solid nests of cells with a microvacuolated basophilic cytoplasm similar to those found in adenosquamous cervical carcinoma of glassy cell type. However, analysis of the patient's past history revealed a lung adenocarcinoma, diagnosed 4 years before, which prompted an immunohistochemical differential diagnosis, showing a strong expression for TTF-1 and Napsin A...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28119270/distribution-of-gastric-carcinoma-in-an-area-with-a-high-prevalence-of-helicobacter-pylori
#13
Javed Yakoob, Syeda Sadia Fatima, Zaigham Abbas, Syed Farrukh Mustafa, Hamza Abdur Rahim Khan, Muhammad Faraz Raghib, Safia Awan, Zubair Ahmad
BACKGROUND/AIMS: South Asia is an enigma for gastric cancer (GC) because it is a low risk region with a high prevalence of Helicobacter pylori (H. pylori) infections. We evaluated the trend of GC clinical presentation and risk factors in patients with dyspeptic symptoms. MATERIALS AND METHODS: The medical records of patients, coded by the international classification of diseases (ICD-10-CM, 2015, Diagnosis Code C16.9) for malignancies of stomach diagnosed by esophagogastroduodenoscopy (EGD) and histopathology, were studied...
March 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28116561/prognostic-impact-of-different-histological-types-on-gastric-adenocarcinoma-a-surveillance-epidemiology-and-end-results-database-analysis
#14
Kaitai Liu, Juefeng Wan, Yanping Bei, Xue Chen, Miaozhen Lu
The clinicopathological characteristics and prognosis of gastric mucinous adenocarcinoma (MAC) and signet ring cell carcinoma (SRC) are still controversial. We designed our study to evaluate the clinicopathologic features and prognosis of MAC, SRC and ordinary gastric adenocarcinoma (OGAC) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database. The 5-year overall survival (OS) of patients with SRC was significantly lower than that of patients with MAC (P = 0.001) and OGAC (P < 0...
January 23, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28078130/radiographic-and-endoscopic-regression-of-metastatic-gastric-cancer-to-the-colon-in-the-setting-of-5-aminosalicylic-acid-use
#15
Yuval A Patel, Shannon J McCall, Xuefeng Zhang, Tracy Jaffe, Rahul A Shimpi
Colonic metastases from gastric cancer are a rare phenomenon and sparsely reported in the literature. We report a case of a 59-year-old woman who presented with vague abdominal symptoms and initial computer tomography (CT) imaging suggestive of a colonic apple-core lesion with serial colonoscopic biopsies diagnostic of metastatic signet ring cell gastric adenocarcinoma. This case is unique given the evolving CT and endoscopic findings that suggested a regression in colonic wall thickening in the setting of 5-aminosalicylic acid (5-ASA) use prior to histologic diagnosis...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28008624/gastric-cancer-in-the-young-an-advanced-disease-with-poor-prognostic-features
#16
Kais A Rona, Katrin Schwameis, Joerg Zehetner, Kamran Samakar, Kyle Green, Jamil Samaan, Kulmeet Sandhu, Nikolai Bildzukewicz, Namir Katkhouda, John C Lipham
BACKGROUND AND OBJECTIVES: Gastric cancer in young patients is rare. We analyzed the clinicopathological features and prognosis of early-onset gastric carcinoma. METHODS: We retrospectively reviewed patients with gastric adenocarcinoma aged ≤45 years and >45 years at our institution over a 17-year period. Clinicopathological features were compared and survival analysis was performed using Kaplan-Meier curves. RESULTS: A total of 121 patients with gastric carcinoma aged ≤45 years were identified...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28008409/a-concurrent-case-of-m%C3%A3-n%C3%A3-trier-s-disease-and-signet-ring-carcinoma
#17
Anderson H Kuo, Nicholas Martinez, Laura Rosenkranz
Ménétrier's disease, also known as hyperplastic protein-losing gastropathy, is a rare, idiopathic, acquired, premalignant condition associated with gastric carcinoma. Its association with signet ring cell cancer of the stomach has been previously reported only twice. We present the third case of histologically confirmed concurrent Ménétrier's disease with signet ring carcinoma of the stomach, interrogated by esophagogastroduodenoscopy and endoscopic ultrasound.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27995193/chromoendoscopy-in-combination-with-random-biopsies-does-not-improve-detection-of-gastric-cancer-foci-in-cdh1-mutation-positive-patients
#18
Robert Hüneburg, Tim Marwitz, Peer van Heteren, Tobias J Weismüller, Jonel Trebicka, Ronja Adam, Stefan Aretz, Alberto Perez Bouza, Dimitrios Pantelis, Jörg C Kalff, Jacob Nattermann, Cristian P Strassburg
Background and study aims: Hereditary diffuse gastric cancer (HGGC), an autosomal dominant tumor-syndrome, accounts for 1 % to 3 % of gastric cancers worldwide. Presumably 30 % to 40 % of all patients fulfilling the clinical guidelines for HDGC are carriers of a pathogenic mutation in the CDH1 gene. Patients often show multiple foci of signet ring cell carcinoma at early age and are advised to undergo prophylactic total gastrectomy (PTG). Our aim was to improve the endoscopic detection of HDGC by using an enhanced endoscopic protocol...
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27990837/unusual-presentation-of-infection-by-helicobacter-pylori-gastritis-associated-with-russell-bodies-infrequent-and-poorly-understood-pathology
#19
Viviana Parra Vargas, Diego M Aponte, Eligio Antonio Álvarez
Russell bodies gastritis is a very rare disease, with few cases reported in literature, and characterized by the finding of plasma cells with eosinophilic intracytoplasmic inclusions in the gastric mucosa, called Mott cells. Although it has been partnered since its first description to Helicobacter pylori infection, it is important to considered differential diagnoses such as lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, plasmacytoma and signet ring cell carcinom. In this case report, we address a patient with histologic confirmation and her follow up...
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27974937/5-year-complex-clinical-and-histopathological-follow-up-of-a-case-of-early-gastric-carcinoma-signet-ring-cells-type
#20
D Serban, C Branescu, C Savlovschi, G Simion, A Mihai, A El-Khatib, C Tudor, A Nica, G Vancea, M Ghelase, A M Dascalu
The paper presents the case of a male patient, hospitalized for acute abdomen due to perforated callous ulcer. Though the clinical appearance suggested a benign pathology, the histopathological exam of the resection piece showed multicentric early gastric carcinoma, signet ring cell type. At the patient's request, total gastrectomy was not performed, a conservative solution being chosen instead. Superior digestive endoscopy with biopsy and oncological dispensarization was performed one month after surgery, then at every 6 months...
July 2016: Journal of Medicine and Life
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