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gastric signet cell

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https://www.readbyqxmd.com/read/28078130/radiographic-and-endoscopic-regression-of-metastatic-gastric-cancer-to-the-colon-in-the-setting-of-5-aminosalicylic-acid-use
#1
Yuval A Patel, Shannon J McCall, Xuefeng Zhang, Tracy Jaffe, Rahul A Shimpi
Colonic metastases from gastric cancer are a rare phenomenon and sparsely reported in the literature. We report a case of a 59-year-old woman who presented with vague abdominal symptoms and initial computer tomography (CT) imaging suggestive of a colonic apple-core lesion with serial colonoscopic biopsies diagnostic of metastatic signet ring cell gastric adenocarcinoma. This case is unique given the evolving CT and endoscopic findings that suggested a regression in colonic wall thickening in the setting of 5-aminosalicylic acid (5-ASA) use prior to histologic diagnosis...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28008624/gastric-cancer-in-the-young-an-advanced-disease-with-poor-prognostic-features
#2
Kais A Rona, Katrin Schwameis, Joerg Zehetner, Kamran Samakar, Kyle Green, Jamil Samaan, Kulmeet Sandhu, Nikolai Bildzukewicz, Namir Katkhouda, John C Lipham
BACKGROUND AND OBJECTIVES: Gastric cancer in young patients is rare. We analyzed the clinicopathological features and prognosis of early-onset gastric carcinoma. METHODS: We retrospectively reviewed patients with gastric adenocarcinoma aged ≤45 years and >45 years at our institution over a 17-year period. Clinicopathological features were compared and survival analysis was performed using Kaplan-Meier curves. RESULTS: A total of 121 patients with gastric carcinoma aged ≤45 years were identified...
December 23, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28008409/a-concurrent-case-of-m%C3%A3-n%C3%A3-trier-s-disease-and-signet-ring-carcinoma
#3
Anderson H Kuo, Nicholas Martinez, Laura Rosenkranz
Ménétrier's disease, also known as hyperplastic protein-losing gastropathy, is a rare, idiopathic, acquired, premalignant condition associated with gastric carcinoma. Its association with signet ring cell cancer of the stomach has been previously reported only twice. We present the third case of histologically confirmed concurrent Ménétrier's disease with signet ring carcinoma of the stomach, interrogated by esophagogastroduodenoscopy and endoscopic ultrasound.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27995193/chromoendoscopy-in-combination-with-random-biopsies-does-not-improve-detection-of-gastric-cancer-foci-in-cdh1-mutation-positive-patients
#4
Robert Hüneburg, Tim Marwitz, Peer van Heteren, Tobias J Weismüller, Jonel Trebicka, Ronja Adam, Stefan Aretz, Alberto Perez Bouza, Dimitrios Pantelis, Jörg C Kalff, Jacob Nattermann, Cristian P Strassburg
Background and study aims: Hereditary diffuse gastric cancer (HGGC), an autosomal dominant tumor-syndrome, accounts for 1 % to 3 % of gastric cancers worldwide. Presumably 30 % to 40 % of all patients fulfilling the clinical guidelines for HDGC are carriers of a pathogenic mutation in the CDH1 gene. Patients often show multiple foci of signet ring cell carcinoma at early age and are advised to undergo prophylactic total gastrectomy (PTG). Our aim was to improve the endoscopic detection of HDGC by using an enhanced endoscopic protocol...
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27990837/unusual-presentation-of-infection-by-helicobacter-pylori-gastritis-associated-with-russell-bodies-infrequent-and-poorly-understood-pathology
#5
Viviana Parra Vargas, Diego M Aponte, Eligio Antonio Álvarez
Russell bodies gastritis is a very rare disease, with few cases reported in literature, and characterized by the finding of plasma cells with eosinophilic intracytoplasmic inclusions in the gastric mucosa, called Mott cells. Although it has been partnered since its first description to Helicobacter pylori infection, it is important to considered differential diagnoses such as lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, plasmacytoma and signet ring cell carcinom. In this case report, we address a patient with histologic confirmation and her follow up...
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27974937/5-year-complex-clinical-and-histopathological-follow-up-of-a-case-of-early-gastric-carcinoma-signet-ring-cells-type
#6
Serban D, Branescu C, Savlovschi C, Simion G, Mihai A, El-Khatib A, Tudor C, Nica A, Vancea G, Ghelase M, Dascalu Am
The paper presents the case of a male patient, hospitalized for acute abdomen due to perforated callous ulcer. Though the clinical appearance suggested a benign pathology, the histopathological exam of the resection piece showed multicentric early gastric carcinoma, signet ring cell type. At the patient's request, total gastrectomy was not performed, a conservative solution being chosen instead. Superior digestive endoscopy with biopsy and oncological dispensarization was performed one month after surgery, then at every 6 months...
July 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27957354/breast-cancer-metastasis-to-the-stomach-that-was-diagnosed-after-endoscopic-submucosal-dissection
#7
Masahide Kita, Masashi Furukawa, Masaya Iwamuro, Keisuke Hori, Yoshiro Kawahara, Naruto Taira, Tomohiro Nogami, Tadahiko Shien, Takehiro Tanaka, Hiroyoshi Doihara, Hiroyuki Okada
A 52-year-old woman presented with stage IIB primary breast cancer (cT2N1M0), which was treated using neoadjuvant chemotherapy (epirubicin, cyclophosphamide, and paclitaxel). However, the tumor persisted in patchy areas; therefore, we performed modified radical mastectomy and axillary lymph node dissection. Routine endoscopy at 8 months revealed a depressed lesion on the gastric angle's greater curvature, and histology revealed signet ring cell proliferation. We performed endoscopic submucosal dissection for gastric cancer, although immunohistochemistry revealed that the tumor was positive for estrogen receptor, mammaglobin, and gross cystic disease fluid protein-15 (E-cadherin-negative)...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27931719/a-potential-pitfall-in-evaluating-her2-immunohistochemistry-for-gastric-signet-ring-cell-carcinomas
#8
Chang Gok Woo, Won Jin Ho, Young Soo Park, Sook Ryun Park, Min-Hee Ryu, Hwoon-Yong Jung, Yoon-Koo Kang
Signet ring cell carcinoma (SRC) more commonly presents as metastatic disease and renders patients to be considered for chemotherapy. While treatment options are limited overall, trastuzumab has been shown to be effective for HER2 positive SRC cases. The current algorithm for HER2 evaluation heavily relies on positive membrane-specific staining by immunohistochemistry (IHC), but several anecdotal reports have suggested that SRCs may be susceptible to misinterpretation due to non-specific staining in the marginated cytoplasm with/without nucleus...
January 2017: Pathology
https://www.readbyqxmd.com/read/27891398/an-unusual-evolution-of-krukenberg-tumour-a-case-report
#9
Claudio Spinelli, Concetta Liloia, Jessica Piscioneri, Clara Ugolini, Silvia Strambi
Krukenberg tumours are rare metastatic tumours of the ovaries characterized by the presence of mucin-producing neoplastic Signet Ring Cell Carcinoma (SRCC). At first glance, this tumour may be confused with a primary ovarian tumour. Surgery and chemotherapy combination have led to improvement in prognosis, but it still remains severe. We report the case of a 60-year-old woman with a Krukenberg tumour rising from a low differentiated gastric adenocarcinoma. The patient was clinically stable for 26 months after surgery until she experienced a prompt decline and died of cerebral haemorrhage within two weeks...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27873158/feasibility-and-importance-of-enteroscopy-after-gastric-bypass
#10
Dean Keren, H Madi, I Matter, A Assalia, T Rainis
BACKGROUND: Bariatric surgery has increased in popularity, with Roux-en-Y Gastric Bypass (RYGB) being one of the most frequently performed. This leads to many cases in which the stomach is removed from routine gastroscopy access, sometimes being a major source of concern. Performing enteroscopy in these patients is technically difficult. We present our experience with 24 cases in which the aim was to access the detached stomach. METHODS: Retrospective analysis on RYGB enteroscopy procedures aimed to access the detached stomach...
November 21, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27861374/a-nomogram-for-predicting-the-likelihood-of-lymph-node-metastasis-in-early-gastric-signet-ring-cell-carcinoma-a-single-center-retrospective-analysis-with-external-validation
#11
Chun Guang Guo, Yan Jia Chen, Hu Ren, Hong Zhou, Ju Fang Shi, Xing Hua Yuan, Ping Zhao, Dong Bing Zhao, Gui Qi Wang
Treatment algorithm has not been established for early gastric cancer with signet ring cell carcinoma (SRC), which has a reported low rate of lymph node metastasis (LNM) similar to differentiated cancer. A cohort of 256 patients with early gastric SRC at our center between January 2002 and December 2015 were retrospectively reviewed. Multivariate logistic regression analysis was used to determine the independent factors of LNM. A nomogram for predicting LNM was constructed and internally validated. Additional external validation was performed using the database from Cancer Institute Ariake Hospital in Tokyo (n = 1273)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858181/intratumor-stromal-proportion-predicts-aggressive-phenotype-of-gastric-signet-ring-cell-carcinomas
#12
Dakeun Lee, In-Hye Ham, Sang Yong Son, Sang-Uk Han, Young-Bae Kim, Hoon Hur
OBJECTIVE: The aim of this study was to evaluate the prognostic significance of the intratumor stromal proportion in gastric signet ring cell (SRC) carcinomas. BACKGROUND: Cancer stroma, as exemplified by cancer-associated fibroblasts (CAFs), plays critical roles in cancer proliferation, invasion, and metastasis. METHODS: One hundred seventy-five SRC carcinoma cases were classified according to the intratumor desmoplastic stromal proportion to then analyze the clinicopathologic characteristics of stroma-rich cases...
November 17, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27849427/generalized-high-bone-mineral-density-on-bone-density-scanning-a-case-of-gastric-carcinoma-with-bone-metastasis
#13
Pianpian Fan, Qin Wang, Chunyan Lu, Deicai Chen
Generalized high bone mineral density (BMD) on Dual-energy X-ray absorptiometry (DXA) scanning most commonly reflects metabolic bone disease. However, some malignancies could also stimulate the underlying processes. We reported that a 41-year-old female was referred for lumbago. She did not complain of any symptoms in the digestive system. DXA revealed high BMD in the lumbar vertebras. Marked increase in bone mass was observed in an X-ray of chest compared with one conducted 6 months previously. Additionally, an X-ray of the axial skeleton showed diffuse sclerotic change...
November 16, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27843583/nanostring-expression-profiling-identifies-candidate-biomarkers-of-rad001-response-in-metastatic-gastric-cancer
#14
Kakoli Das, Xiu Bin Chan, David Epstein, Bin Tean Teh, Kyoung-Mee Kim, Seung Tae Kim, Se Hoon Park, Won Ki Kang, Steve Rozen, Jeeyun Lee, Patrick Tan
BACKGROUND: Gene expression profiling has contributed greatly to cancer research. However, expression-driven biomarker discovery in metastatic gastric cancer (mGC) remains unclear. A gene expression profile predicting RAD001 response in refractory GC was explored in this study. METHODS: Total RNA isolated from 54 tumour specimens from patients with mGC, prior to RAD001 treatment, was analysed via the NanoString nCounter gene expression assay. This assay targeted 477 genes representing 10 different GC-related oncogenic signalling and molecular subtype-specific expression signatures...
2016: ESMO Open
https://www.readbyqxmd.com/read/27828821/a-risk-prediction-model-based-on-lymph-node-metastasis-for-incorporation-into-a-treatment-algorithm-for-signet-ring-cell-type-intramucosal-gastric-cancer
#15
Jeung Hui Pyo, Cheol Min Shin, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Su Mi Kim, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Kyung Mee Kim, Hye Seung Kim, Sin-Ho Jung, Jae J Kim, Sung Kim
OBJECTIVE: The aim of the study was to develop a reliable and easy-to-use risk-scoring system (RSS) to predict lymph-node metastasis (LNM) and determine the feasibility of endoscopic submucosal dissection for mucosa-confined signet ring cell carcinomas (SRCs). BACKGROUND: Fewer LNM and better survival rates have been reported for early gastric SRCs compared with other undifferentiated early gastric cancers (EGCs). METHODS: Data from 1544 patients with mucosa-confined SRCs were reviewed...
December 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27798928/signet-ring-cells-and-efficacy-of-first-line-chemotherapy-in-advanced-gastric-or-oesogastric-junction-adenocarcinoma
#16
Nathalie Lemoine, Antoine Adenis, Olivier Bouche, Alain Duhamel, Alexandra Heurgue, Emmanuelle Leteurtre, Eric Amela, Julia Salleron, Mohamed Hebbar
AIM: To evaluate the efficacy of first-line palliative chemotherapy, regarding the presence of signet ring cells (SRC). PATIENTS AND METHODS: Retrospective analysis of consecutive patients with locally advanced or metastatic gastric or oesogastric junction adenocarcinoma who received first-line chemotherapy. Response to chemotherapy, progression-free survival (PFS) and overall survival (OS) were compared between SRC and non-SRC (NSRC) groups. RESULTS: Two hundred and three patients were treated, with 57 (28%) having SRC adenocarcinoma...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27783218/helicobacter-pylori-negative-gastric-cancer-advanced-stage-undifferentiated-adenocarcinoma-located-in-the-pyloric-gland-area
#17
Akihiro Okano, Shigeru Kato, Masaya Ohana
The incidence of Helicobacter pylori-negative gastric cancer (HpNGC) is extremely low. A 78-year old female without H. pylori infection was diagnosed with type 4 advanced-stage gastric prepylorus cancer. Distal gastrectomy was performed as for HpNGC (cT3N0M0). Histological findings of the resected specimen showed poorly differentiated adenocarcinoma and signet ring cell carcinoma, which were located in the pyloric gland area, diffusely invaded beyond the serosa without lymph node metastasis (pT4aN0M0). Most cases of undifferentiated-type HpNGC are diagnosed in the early stage and are located in the fundic gland area...
October 25, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27759617/total-gastrectomy-for-hereditary-diffuse-gastric-cancer-at-a-single-center-postsurgical-outcomes-in-41-patients
#18
Vivian E Strong, Sepideh Gholami, Manish A Shah, Laura H Tang, Yelena Y Janjigian, Mark Schattner, Luke V Selby, Sam S Yoon, Erin Salo-Mullen, Zsofia K Stadler, David Kelsen, Murray F Brennan, Daniel G Coit
OBJECTIVE: The aim of this study was to describe postoperative outcomes of total gastrectomy at our institution for patients with hereditary diffuse gastric cancer (HDGC). BACKGROUND: HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy. METHODS: A prospective gastric cancer database identified 41 patients with CDH1 mutation who underwent total gastrectomy during 2005 to 2015...
October 17, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27721760/exophthalmos-revealing-a-krukenberg-tumor-a-case-presentation-and-review-of-the-literature
#19
Mohamed Fetohi, Sanaa Errarhay, Aziz Bazine, Tarikq Namad
BACKGROUND: Krukenberg tumor is a well-known ovarian metastasis, usually of signet ring cell carcinoma in female patients. In the literature, there are a few documented cases of ocular metastasis in patients with Krukenberg tumor. CASE PRESENTATION: We report the case of a 35-year-old single Moroccan woman. She presented chronic pelvic pain, hematemesis and blurring of vision in the left eye. Clinical examination showed a pelvic mass and an exophthalmos with a divergent strabismus in the left eye...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27696013/ultrasound-findings-of-diffuse-metastasis-of-gastric-signet-ring-cell-carcinoma-to-the-thyroid-gland
#20
Koji Morita, Takahiko Sakamoto, Shuji Ota, Hideo Masugi, Ikumi Chikuta, Yamato Mashimo, Naoki Edo, Takuo Tokairin, Nobuhiko Seki, Toshio Ishikawa
It has been shown that metastases to the thyroid from extrathyroidal malignancies occur as solitary or multiple nodules, or may involve the whole thyroid gland diffusely. However, diffuse metastasis of gastric cancer to the thyroid is extremely rare. Here, we report a case of a 74-year-old woman with diffuse infiltration of gastric adenocarcinoma (signet-ring-cell carcinoma/poorly differentiated adenocarcinoma) cells in the thyroid. The pathological diagnosis was made based on upper gastrointestinal endoscopy with biopsy and fine-needle aspiration cytology of the thyroid...
October 1, 2016: Journal of Medical Ultrasonics
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