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https://www.readbyqxmd.com/read/29774226/metastatic-gastric-signet-ring-cell-carcinoma-mimicking-crohn-s-disease
#1
Michael W Winter, Amr Dokmak, Zachary Marnoy, Shweta Sinagare, Alexander N Levy
Signet-ring cell carcinoma (SRCC) is an adenocarcinoma characterized by mucin-producing cells and most commonly arises in the stomach. Colonic SRCC can share features of colitis, including long segments of concentric bowel wall thickening and ulcerated mucosa with regions of sparing. We describe a rare case of metastatic gastric SRCC mimicking Crohn's disease. Our patient underwent 2 colonoscopies, and biopsies revealed chronic active inflammation with no evidence of malignancy. The diagnosis of SRCC was only made after colectomy was performed for recurrent bowel obstruction...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29729716/diffuse-type-gastric-mucinous-and-signet-ring-cell-adenocarcinoma-in-a-captive-california-king-snake-lampropeltis-getula-californiae
#2
C-S Hsueh, W-T Li, C-R Jeng, V F Pang, H-W Chang
An adult female California king snake (Lampropeltis getula californiae) housed in Taipei Zoo was presented with a 2-week history of anorexia, fatigue and abdominal swelling. Exploratory laparotomy revealed a gastric mass with two circular perforations and multiple mottled white to beige protuberances along the mucosal surface. Histologically, the gastric mass showed an invasive, transmural growth of epithelial cells arranged in nests, lobules, acini and sheets in the mucosa and submucosa that progressively transformed into signet ring cells in the muscularis externa and subserosa...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29719284/characterization-of-helicobacter-pylori-na%C3%A3-ve-early-gastric-cancers
#3
Akihiro Yamada, Mitsuru Kaise, Naoko Inoshita, Takahito Toba, Kosuke Nomura, Yasutaka Kuribayashi, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya
AIM: Helicobacter pylori-naïve gastric cancers(GCs) have not been well documented. We aimed to characterize early H. pylori-naïve GCs. SUBJECTS AND METHODS: Of 666 patients with GC resected by endoscopic submucosal dissection, H. pylori-naïve patients were extracted according to the definition: no H. pylori eradication history, negative for serum H. pylori-antibody and current H. pylori-infection tests, and no gastric atrophy by pepsinogen (PG) test, endoscopy, and histology...
May 2, 2018: Digestion
https://www.readbyqxmd.com/read/29695579/superficial-spreading-type-gastric-cancer-with-situs-inversus-totalis
#4
Tsutomu Namikawa, Sachi Tsuda, Kazune Fujisawa, Jun Iwabu, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
Situs inversus totalis (SIT) is a congenital anomaly characterized by a complete mirror-image transposition of the thoracic and abdominal viscera. We report on a rare case of superficial spreading gastric cancer associated with SIT in a 66-year-old woman referred to our hospital for examination of gastric cancer initially diagnosed by medical check-up. Esophagogastroduodenoscopy showed a slightly depressed lesion in the lesser curvature side of the stomach. Abdominal contrast-enhanced computed tomography showed complete transposition of the abdominal viscera, confirming SIT...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29694966/gastric-adenocarcinomas-in-central-tunisia-evolution-specificities-through-two-decades-and-relation-with-helicobacter-pylori
#5
Mohamed Amine Elghali, Amine Gouader, Rym Bouriga, Mohamed Mahjoub, Mohamed Salah Jarrar, Sonia Ziadi, Moncef Mokni, Fahmi Hamila, Rached Ltaeif
INTRODUCTION: In developed countries, authors have reported variations over time in the seat and histological type of gastric adenocarcinomas, which were explained by Helicobacter pylori infection (HPI) incidence changes. In North-African countries and the Arabic world, epidemiological changes in gastric adenocarcinomas are still unknown. Our study aims to explore and to describe those changes in central Tunisia. MATERIALS AND METHODS: This is a retrospective observational and descriptive study including 876 cases based on the National Central Tunisian Register of Cancers over a period of 21 years...
April 25, 2018: Oncology
https://www.readbyqxmd.com/read/29643292/-a-case-of-postoperative-recurrent-gastric-cancer-resembling-esophageal-achalasia-diagnosed-by-staging-laparoscopy
#6
Masayuki Kabayama, Fumisato Sasaki, Hidehito Maeda, Shiho Arima, Shiroh Tanoue, Yuichiro Nasu, Shinichi Hashimoto, Shuji Kanmura, Jun Kadono, Akio Ido
A 65-year-old man underwent subtotal gastrectomy for advanced gastric cancer. The histological type of the cancer was signet-ring cell carcinoma, and the clinical stage was stage IB (T2N0M0). Three years after surgery, the patient had the following symptoms:dysphagia, odynophagia, and weight loss. Esophageal endoscopy and esophagography revealed a circular stenosis covered with the normal mucosa between the middle esophagus and the esophagogastric junction. Histologically, the samples obtained by staging laparoscopy revealed signet-ring cell carcinoma...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29572728/-68-ga-labelled-psma-prostate-specific-membrane-antigen-expression-in-signet-ring-cell-gastric-carcinoma
#7
Dharmender Malik, Rajender Kumar, Bhagwant Rai Mittal, Harmandeep Singh, Anish Bhattacharya, Ashwani Sood, Vishal Sharma, Harjeet Singh
No abstract text is available yet for this article.
March 23, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29572575/metastatic-colonic-and-gastric-polyps-from-breast-cancer-resembling-hyperplastic-polyps
#8
Yoshiya Horimoto, Tetsuro Hirashima, Atsushi Arakawa, Hiroyoshi Miura, Mitsue Saito
Breast cancer metastasis to the gastrointestinal tract is relatively rare and is generally found when patients complain of symptoms such as gastrointestinal obstruction. Herein, we report a case with metastatic colonic and gastric lesions from breast cancer, with the formation of mucosal polyps which resembled typical hyperplastic polyps.A 47-year-old woman underwent curable surgery for breast cancer and received standard systemic treatments. Her primary tumor was composed of a mix of invasive lobular and ductal carcinomas...
March 23, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29553397/the-amount-of-cells-with-signet-ring-cell-morphology-has-a-prognostic-impact-in-poorly-cohesive-gastric-carcinoma
#9
M Bencivenga, E Treppiedi, G Verlato, V Mengardo, S Giacopuzzi, G de Manzoni
No abstract text is available yet for this article.
March 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29553388/signet-ring-cell-carcinoma-in-the-stomach-histopathological-definitions-and-response-to-therapy-assessment-the-urgent-need-for-an-international-consensus
#10
https://www.readbyqxmd.com/read/29533002/differences-in-clinicopathological-characteristics-and-computed-tomography-findings-between-signet-ring-cell-carcinoma-and-nonsignet-ring-cell-carcinoma-in-early-and-advanced-gastric-cancer
#11
Jian Chen, Rong Cai, Gang Ren, Jianxi Zhao, Huali Li, Chen Guo, Wenguang He, Xiangru Wu, Wenjie Zhang
Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics. SRC's clinicopathological characteristics and prognosis are still controversial. Our study is to describe the clinicopathological features and multidetector computed tomography (MDCT) findings of patients with SRC of the stomach in comparison with nonsignet ring cell adenocarcinoma (NSRC). We retrospectively analyzed data from 241 patients who had undergone curative gastrectomy, including 62 SRC and 179 NSRC...
April 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29511550/endoscopic-submucosal-dissection-of-gastric-superficial-neoplastic-lesions-a-single-western-center-experience
#12
Lucio Petruzziello, Mariachiara Campanale, Cristiano Spada, Riccardo Ricci, Cesare Hassan, Gaia Gullo, Guido Costamagna
Background: Endoscopic submucosal dissection (ESD) allows "en bloc" resection of superficial gastric lesions. Objective: The aim of this study is to report "en bloc" resection rate, procedure results, post resection features, analysis of complications, and relapses at mid-long term follow-up on an Italian center case series of patients with superficial gastric neoplastic lesions treated with ESD. Methods: This is a retrospective evaluation of a prospectively collected series of patients diagnosed with gastric superficial lesions who underwent ESD between November 2007 and May 2015...
March 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29492918/-surgical-treatment-and-prognosis-of-borrmann-type-iiii-gastric-cancer-involving-the-whole-stomach
#13
Ruizeng Dong, Zewei Zhang, Yiming Zhou, Yonghong Hua, Jianmin Guo
OBJECTIVE: To explore the surgical treatment and prognosis of Borrmann type IIII( gastric cancer involving the whole stomach. METHODS: Clinicopathological characteristics and survival data of 223 patients with Borrmann type IIII( gastric cancer involving the whole stomach (defined as the tumor infiltrating 3 regions of the stomach) receiving surgical treatment at the Department of Abdominal Surgery of Zhejiang Cancer Hospital between January 2002 and December 2015 were analyzed retrospectively...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29450754/neural-invasion-is-a-significant-contributor-to-peritoneal-recurrence-in-signet-ring-cell-gastric-carcinoma
#14
Dakeun Lee, Sang-Yong Son, Young-Bae Kim, Sang-Uk Han, Hoon Hur
BACKGROUND: Gastric signet ring cell carcinoma (SRC) has shown a favorable outcome in early stages but has a worse prognosis than non-SRC in advanced stages. However, the cause for this stage-dependent prognostic impact has not been determined. This study aimed to compare clinicopathologic features and recurrence patterns between gastric SRC and non-SRC in a cohort of Eastern patients. METHODS: This study reviewed the prospectively collected data of 764 patients undergoing curative resection for gastric cancer from 2005 to 2008...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29441461/superficially-spreading-signet-ring-cell-carcinoma-perpendicularly-colliding-with-gastric-adenoma-a-rare-case-report
#15
Takayuki Minami, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Hidemasa Nagai, Kanji Miyata, Ayami Kiriyama
No abstract text is available yet for this article.
February 14, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29434119/a-case-of-helicobacter-pylori-negative-advanced-gastric-cancer-with-massive-eosinophilia
#16
Atsushi Takagi, Hideki Ozawa, Masayuki Oki, Hidetaka Yanagi, Kazuhito Nabeshima, Naoto Nakamura
The incidence of Helicobacter pylori-negative gastric cancer is very low. A 60-year-old man was referred to Tokai University Hospital from a local clinic because of eosinophilia. The laboratory data revealed prominent eosinophilia, with a white blood cell count of 7,900/μl and increased eosinophil granulocyte level of 1,659/μl. After an examination for secondary eosinophilia, esophagogastroduodenoscopy showed an enlarged gastric fold in the corpus, suggesting type 4 gastric cancer. Repeated EGD and a re-biopsy demonstrated poorly differentiated adenocarcinoma and signet ring cell carcinoma...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29425880/protoporphyrinogen-oxidase-is-involved-in-the-fluorescence-intensity-of-5-aminolevulinic-acid-mediated-laser-based-photodynamic-endoscopic-diagnosis-for-early-gastric-cancer
#17
Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto
BACKGROUND/AIM: Laser-based photodynamic endoscopic diagnosis (LPDED) is a type of endoscopic diagnosis that uses the fluorescence caused by the photochemical reaction that occurs when a fluorescent substance is irradiated by a light of a specific wavelength. Although 5-aminolevulinic acid (5-ALA) can detect early gastric cancer (EGC) during LPDED, there is an unresolved issue of the differences in fluorescence intensity among histopathological types of gastric cancer. Thus, the aim of the present study was to assess whether protoporphyrinogen oxidase (PPOX), involved in the activation of protoporphyrin IX, can affect the fluorescence intensity in EGC...
February 6, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29394844/-a-case-of-qol-improvement-after-intestinal-stenosis-due-to-peritoneal-dissemination-of-gastric-cancer-in-elderly-patients
#18
Katsumi Shimomura, Yuki Furuke, Yukie Tanaka, Tatsuya Kumano, Syuhei Komatsu, Kenichiro Imura, Jun Ikeda, Fumihiro Taniguchi, Yasuhiro Shioaki, Yoshikazu Nakatsugawa
Nearly 70% of gastric cancer recurrences occur as peritoneal dissemination. Most of the treatment for recurrence of gastric cancer dissemination is chemotherapy; depending on the symptoms and the site of recurrence, palliative bypass surgery may be performed. Intensive treatment is often difficult for elderly patients over 85-years-old. This case was a 91-year-old female who underwent total gastrectomy for gastric cancer(signet-ring cell carcinoma)7years prior. Two years ago, a stenosis due to recurrence was revealed in the small intestine and bypass surgery was performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394705/-a-case-of-metastases-to-the-bone-skin-and-ovary-from-gastric-cancer-occurring-more-than-eight-years-after-distal-gastrectomy
#19
Yukari Woo, Shigeru Fujisaki, Motoi Takashina, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
We report a 72-year-old woman with rare metastases of gastric cancer to the bone, skin, and ovary occurring more than 8 years after distal gastrectomy, which were subsequently effectively controlled. Histopathological diagnosis revealed signetring cell carcinoma, and the comprehensive findings were pT4a, pN3, ly2, v0, and Stage III c. The adjuvant chemotherapy of S- 1 plus cisplatin(CDDP)was switched to S-1monotherapy for 4 years and then to tegafur/uracil(UFT)for an additional year. Eight years after the operation, I-CTP and alkaline phosphatase(ALP)levels were elevated, and bone scintigraphy revealed bone metastasis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394614/-a-case-of-advanced-gastric-cancer-responding-effectively-to-neoadjuvant-chemotherapy
#20
Kentaro Kawamitsu, Takashi Ooshiro, Daiki Nabekura, Kengo Kadoya, Ayami Sato, Tomoyuki Kitahara, Ryuichi Takagi, Ayako Hiranuma, Tasuku Urita, Yutaka Yoshida, Yu Sato, Hiroshi Tanaka, Makoto Nagashima, Shinichi Okazumi, Ryoji Kato
A 78-year-old man underwent an upper gastrointestinal endoscopy for evaluation of epigastralgia. Endoscopy revealed a bulky type 3 tumor in the lesser curvature of the upper body. A biopsy showed a poorly differentiated adenocarcinoma with signet ring cell carcinoma. Additionally, abdominal computed tomography(CT)showed bulky lymph node metastases leading to a diagnosis of cT3N2M0, Stage III A carcinoma. Following administration of 2 courses of neoadjuvant chemotherapy (NAC)using S-1/cisplatin(CDDP), CT revealed significant regression of the primary lesion and lymph nodes...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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