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https://www.readbyqxmd.com/read/29929019/the-rehabilitation-of-advanced-heart-failure-patients-after-left-ventricular-assist-device-a-narrative-review
#1
REVIEW
Sarah M Eickmeyer, Kim D Barker, Anjum Sayyad, Leslie Rydberg
As an increasing number of patients with advanced heart failure are receiving a Left Ventricular Assist Device (LVAD) as either destination therapy or bridge to transplantation, there is increasing attention on functional outcomes and quality of life after LVAD implantation. Rehabilitation providers in the acute inpatient rehabilitation setting increasingly will treat patients with LVAD and should understand the exercise physiology, medical management, rehabilitation considerations, and outcomes after rehabilitation for patients with LVAD...
June 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29928951/higher-serum-levels-of-pro-hepcidin-in-patients-with-parkinson-s-disease-treated-with-deep-brain-stimulation
#2
J Kwiatek-Majkusiak, M Geremek, D Koziorowski, R Tomasiuk, S Szlufik, A Friedman
Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6. It can therefore be regarded as a link between the oxidative stress processes, where iron plays an important role, and the processes of neuroinflammation - both considered to be responsible for the neurodegeneration in Parkinson's disease. We assessed the serum level of pro-hepcidin in patients with Parkinson's disease treated only pharmacologically and those treated additionally with deep brain stimulation (DBS) as compared to the control group...
June 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29928924/navigate-ii-randomized-double-blind-trial-of-the-exhalation-delivery-system-with-fluticasone-eds-flu-for-nasal-polyposis
#3
Donald A Leopold, David Elkayam, John C Messina, Colette Kosik-Gonzalez, Per G Djupesland, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is common and sometimes complicated by nasal polyps (NP). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation. OBJECTIVE: Assess whether an exhalation delivery system with fluticasone (EDS-FLU), capable of high/deep drug deposition, improves outcomes. METHODS: Patients (N=323) ≥18 years with moderate-to-severe congestion and NP were randomized to twice-daily EDS-FLU (93, 186, or 372μg) or EDS-placebo for 24 weeks (16 double-blind [DB] plus 8 open-label [OL] when all received 372μg)...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928794/evolution-of-the-us-energy-system-and-related-emissions-under-varying-social-and-technological-development-paradigms-plausible-scenarios-for-use-in-robust-decision-making
#4
Kristen E Brown, Troy Alan Hottle, Rubenka Bandyopadhyay, Samaneh Babaee, Rebecca Susanne Dodder, Pervin Ozge Kaplan, Carol Lenox, Dan Loughlin
The energy system is the primary source of air pollution. Thus, evolution of the energy system into the future will affect society's ability to maintain air quality. Anticipating this evolution is difficult because of inherent uncertainty in predicting future energy demand, fuel use, and technology adoption. We apply Scenario Planning to address this uncertainty, developing four very different visions of the future. Stakeholder engagement suggested technological progress and social attitudes toward the environment are critical and uncertain factors for determining future emissions...
June 21, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29928706/variability-of-clinical-target-volume-delineation-for-rectal-cancer-patients-planned-for-neoadjuvant-radiotherapy-with-the-aid-of-the-platform-anatom-e
#5
Pierfrancesco Franco, Francesca Arcadipane, Elisabetta Trino, Elena Gallio, Stefania Martini, Giuseppe Carlo Iorio, Cristina Piva, Francesco Moretto, Maria Grazia Ruo Redda, Roberta Verna, Vassiliki Tseroni, Cristina Bona, Gabriele Pozzi, Christian Fiandra, Riccardo Ragona, Oscar Bertetto, Umberto Ricardi
Objective: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. Materials and methods: Two clinical cases of locally advanced rectal cancer were chosen...
June 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928634/evaluation-of-targeted-image-guided-radiation-therapy-treatment-planning-system-by-use-of-american-association-of-physicists-in-medicine-task-group-119-test-cases
#6
Mohsen Saeb, Daryoush Shahbazi-Gahrouei, Shahram Monadi
Background: This study aimed to evaluate the overall accuracy of the beam commissioning criteria of targeted image-guided radiation therapy (TiGRT) treatment planning system (TPS) based on the American Association of Physicists in Medicine (AAPM) Task Group Report 119 (TG-119). Methods: The work was performed using 6 MV energy LINAC with a variable dose rate of 200 MU/min which equipped with the high-quality external TiGRT dynamic multileaf collimator model H. The AAPM TG-119 intensity-modulated radiation therapy (IMRT) commissioning tests are composed of two preliminary tests and four clinical test cases...
April 2018: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29928535/field-study-of-effects-of-night-shifts-on-cognitive-performance-salivary-melatonin-and-sleep
#7
Reza Kazemi, Majid Motamedzade, Rostam Golmohammadi, Hamidreza Mokarami, Rasoul Hemmatjo, Rashid Heidarimoghadam
Background: Night shift work is associated with many problems such as sleep deprivation, sleepiness, decreased cognitive performance, increased human errors, and fatigue. This study set out to measure cognitive performance, melatonin rhythms, and sleep after different consecutive night shifts (7 vs. 4) among control room operators (CORs). Methods: The participants included 60 CORs with a mean age of 30.2 years (standard deviation, 2.0) from a petrochemical complex located in Southern Iran...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928523/muscle-atrophy-in-chronic-obstructive-pulmonary-disease-molecular-basis-and-potential-therapeutic-targets
#8
REVIEW
Esther Barreiro, Ariel Jaitovich
Patients with chronic obstructive pulmonary disease (COPD) experience several systemic manifestations such skeletal muscle dysfunction with and without muscle mass loss. Moreover, frequent comorbidities such as nutritional abnormalities, heart failure, and pulmonary hypertension, which are frequently associated with COPD may further contribute to skeletal muscle mass loss and dysfunction. Muscle dysfunction impairs the patients' exercise capacity and quality of life as daily life activities may be hampered by this problem...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928521/pulmonary-rehabilitation-in-patients-with-an-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#9
REVIEW
Sarah E Jones, Ruth E Barker, Claire M Nolan, Suhani Patel, Matthew Maddocks, William D C Man
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are one of the most common causes of emergency hospital admission and place great burden upon healthcare systems. Furthermore, AECOPD represent an important life event for patients, and are associated with significant reductions in physical activity, skeletal muscle function, exercise tolerance and health-related quality of life. Pulmonary rehabilitation, an intervention comprising supervised exercise-training and education, may counteract these negative consequences and target modifiable risk factors for hospital readmission...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928520/can-muscle-protein-metabolism-be-specifically-targeted-by-nutritional-support-and-exercise-training-in-chronic-obstructive-pulmonary-disease
#10
REVIEW
Ramzi Lakhdar, Roberto A Rabinovich
Chronic obstructive pulmonary disease (COPD) associates with several extra-pulmonary effects. Muscle dysfunction and wasting is one of the most prominent extra-pulmonary effects and contributes to exercise limitation and health related quality of life (HRQoL), morbidity as well as mortality. The loss of muscle mass is characterised by an impaired balance between protein synthesis (anabolism) and protein breakdown (catabolism) which relates to nutritional disturbances, muscle disuse and the presence of a systemic inflammation, among other factors...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928517/nutritional-status-and-muscle-dysfunction-in-chronic-respiratory-diseases-stable-phase-versus-acute-exacerbations
#11
REVIEW
Joaquim Gea, Antoni Sancho-Muñoz, Roberto Chalela
Nutritional abnormalities are frequent in different chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), interstitial fibrosis and lung cancer, having important clinical consequences. However, nutritional abnormalities often remained underdiagnosed due to the relative lack of awareness of health professionals. Therefore, systematic anthropometry or even better, assessment of body composition, should be performed in all patients with chronic respiratory conditions, especially following exacerbation periods when malnutrition becomes more accentuated...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29928351/gastrointestinal-metastasis-of-primary-lung-cancer-an-analysis-of-366-cases
#12
Yue Hu, Noah Feit, Yanqin Huang, Wenhong Xu, Shu Zheng, Xiuzhen Li
The gastrointestinal (GI) tract is not a common site of metastasis in primary lung cancer. The aim of the present study was to reveal the clinical and prognostic characteristics of gastrointestinal metastases of lung cancer (GMLC). Information on 366 cases of GMLC was collected and factors that affect severe GI complications were analyzed. Univariate and multivariate survival analyses were performed using the Cox proportional hazards model. Of the cases analyzed, the small intestine (59.6%) and colorectum (25...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928243/expressive-morphological-skills-of-dual-language-learning-and-monolingual-german-children-exploring-links-to-duration-of-preschool-attendance-classroom-quality-and-classroom-composition
#13
Lilly-Marlen Bihler, Alexandru Agache, Katja Schneller, Jessica A Willard, Birgit Leyendecker
A growing body of research has been documenting environmental factors that support preschoolers' vocabulary skills. However, less is known about how environmental factors are related to morphological skills of dual language learners (DLLs) and single language learners (SLLs). We examined connections with preschool experiences by investigating the effects of duration of preschool attendance, classroom quality, and classroom composition variables (percentage of DLLs and percentage of children from families with a low socio-economic status) on preschoolers' expressive morphological skills...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29928141/assessment-and-management-of-patients-with-intestinal-failure-a-multidisciplinary-approach
#14
REVIEW
Jennie T Grainger, Yasuko Maeda, Suzanne C Donnelly, Carolynne J Vaizey
Intestinal failure (IF) is a condition characterized by the inability to maintain a state of adequate nutrition, or fluid and electrolyte balance due to an anatomical or a physiological disorder of the gastrointestinal system. IF can be an extremely debilitating condition, significantly affecting the quality of life of those affected. The surgical management of patients with acute and chronic IF requires a specialist team who has the expertise in terms of technical challenges and decision-making. A dedicated IF unit will have the expertise in patient selection for surgery, investigative workup and planning, operative risk assessment with relevant anesthetic expertise, and a multidisciplinary team with support such as nutritional expertise and interventional radiology...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29928122/the-effect-of-evening-primrose-oil-on-fatigue-and-quality-of-life-in-patients-with-multiple-sclerosis
#15
Nastaran Majdinasab, Foroogh Namjoyan, Mohsen Taghizadeh, Hamid Saki
Background: Multiple sclerosis (MS) is a chronic progressive and inflammatory disease of the central nervous system that is characterized by demyelination in the central nervous system. In regard to the prevalence of diseases and enormous costs imposed on society and the health system, finding a way to stop the progression of the disease using drugs with fewer side effects seems a serious sanitation issue to the health of the international community. This study aimed to evaluate the effect of evening primrose oil (EPO) on fatigue and quality of life in patients with MS...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29928118/inhaled-glycopyrrolate-for-the-treatment-of-chronic-obstructive-pulmonary-disease
#16
REVIEW
Donald P Tashkin, Nicholas J Gross
Long-acting muscarinic antagonists (LAMAs), along with long-acting β2 -agonists (LABAs), are the mainstay for treatment of patients with COPD. Glycopyrrolate, or glycopyrronium bromide, like other LAMAs, inhibits parasympathetic nerve impulses by selectively blocking the binding of acetylcholine to muscarinic receptors. Glycopyrrolate is unusual in that it preferentially binds to M3 over M2 muscarinic receptors, thereby specifically targeting the primary muscarinic receptor responsible for bronchoconstriction occurring in COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29928116/cultural-and-quality-of-life-considerations-when-administering-corticosteroids-as-a-therapeutic-strategy-for-african-american-women-living-with-systemic-lupus-erythematosus
#17
Dorcey L Applyrs, Edith M Williams, Trevor D Faith, Diane L Kamen, Elizabeth Vazques, Janine M Jurkowski
Objective: This study investigated the association among corticosteroids, emotional health, physical health, and work/regular activities of daily living in an ethnically diverse sample of women with systemic lupus erythematosus. Methods: A secondary analysis of data from the Medical University of South Carolina Lupus Database was conducted between confirmed cases of lupus (n = 224) and controls (n = 60). The sample comprised 57 Caucasian Americans, 141 Gullah African Americans (a subpopulation of African Americans from the Sea Islands of South Carolina and Georgia), and 86 non-Gullah African Americans...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29928112/chloroquine-and-hydroxychloroquine-are-associated-with-reduced-cardiovascular-risk-a-systematic-review-and-meta-analysis
#18
Dan Liu, Xiaodan Li, Yonggang Zhang, Joey Sum-Wing Kwong, Ling Li, Yiyi Zhang, Chang Xu, Qianrui Li, Xin Sun, Haoming Tian, Sheyu Li
Background and aims: Chloroquine (CQ) and hydroxychloroquine (HCQ) are widely used in patients with rheumatic diseases, but their effects on the cardiovascular system remain unclear. We aimed to assess whether CQ/HCQ could reduce the risk of cardiovascular disease (CVD). Materials and methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, and the ClinicalTrials.gov for studies investigating the association between CQ/HCQ and the risk of CVD from inception to 20 December 2017...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29928033/the-gap-between-cause-of-death-statistics-and-household-registration-reports-in-shandong-china-during-2011-2013-evaluation-and-adjustment-for-underreporting-in-the-mortality-data-for-262-subcounty-level-populations
#19
Jiandong Sun, Xiaolei Guo, Zilong Lu, Zhentao Fu, Xiujun Li, Jie Chu, Gaohui Zhang, Kou Kou, Fuzhong Xue, Aiqiang Xu
Underreporting is a quality concern in mortality statistics. The purpose of this study was to assess and adjust underreporting in the population-based cause-of-death statistics. The total population (96 million) in Shandong, China was divided into 262 subcounty level populations geographically and by residence type (urban/rural). For each subpopulation, the total number of deaths during the years 2011-2013 was determined using data from the Household Registration System (HRS), and was used as a reference to assess the underreporting rate (UR) in the cause-of-death data from the Shandong Death Registration System (SDRS)...
2018: PloS One
https://www.readbyqxmd.com/read/29928017/the-contribution-of-cause-effect-link-to-representing-the-core-of-scientific-paper-the-role-of-semantic-link-network
#20
Mengyun Cao, Xiaoping Sun, Hai Zhuge
The Semantic Link Network is a general semantic model for modeling the structure and the evolution of complex systems. Various semantic links play different roles in rendering the semantics of complex system. One of the basic semantic links represents cause-effect relation, which plays an important role in representation and understanding. This paper verifies the role of the Semantic Link Network in representing the core of text by investigating the contribution of cause-effect link to representing the core of scientific papers...
2018: PloS One
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