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https://www.readbyqxmd.com/read/29444369/rotaviral-non-structural-protein-4-triggers-dynamin-related-protein-1-dependent-mitochondrial-fragmentation-during-infection
#1
Arpita Mukherjee, Upayan Patra, Rahul Bhowmick, Mamta Chawla-Sarkar
Dynamic equilibrium between mitochondrial fission and mitochondrial fusion serves as an important quality control system within cells ensuring cellular vitality and homeostasis. Viruses often target mitochondrial dynamics as a part of their obligatory cellular reprogramming. The present study was undertaken to assess the status and regulation of mitochondrial dynamics during rotavirus (RV) infection. Distinct fragmentation of mitochondrial syncytia was observed during late hours of RV (SA11, Wa, A5-13) infection...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29444307/senescence-and-nitrogen-use-efficiency-in-perennial-grasses-for-forage-and-biofuel-production
#2
Jiading Yang, Michael Udvardi
Organ senescence is an important developmental process in plants that enables recycling of nutrients, such as nitrogen, to maximize reproductive success. Nitrogen is the mineral nutrient required in greatest amount by plants, although soil-N limits plant productivity in many natural and agricultural systems, especially systems that receive little or no fertilizer-N. Use of industrial N-fertilizers in agriculture increased crop yields several fold over the past century, although at substantial cost to fossil energy reserves and the environment...
February 12, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29444278/effectiveness-of-modified-oral-steroid-administration-for-preventing-esophageal-stricture-after-entire-circumferential-endoscopic-submucosal-dissection
#3
T Iizuka, D Kikuchi, S Hoteya, M Kaise
Esophageal stricture occurs at a high rate after endoscopic submucosal dissection, especially after entire circumferential dissection, leading to poor quality of life. This retrospective cohort study evaluated the stricture rate in circumferential mucosal defect cases following modified steroid administration. We enrolled 22 consecutive patients who underwent entire circumferential endoscopic submucosal dissection for superficial esophageal cancer between April 2010 and April 2015 at our hospital. Until January 2013, a systemic steroid-prednisolone-was administered at 30 mg/day and tapered over 8 weeks in the original method group (original group)...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444205/ssbio-a-python-framework-for-structural-systems-biology
#4
Nathan Mih, Elizabeth Brunk, Ke Chen, Edward Catoiu, Anand Sastry, Erol Kavvas, Jonathan M Monk, Zhen Zhang, Bernhard O Palsson, Alfonso Valencia
Summary: Working with protein structures at the genome-scale has been challenging in a variety of ways. Here, we present ssbio, a Python package that provides a framework to easily work with structural information in the context of genome-scale network reconstructions, which can contain thousands of individual proteins. The ssbio package provides an automated pipeline to construct high quality genomescale models with protein structures (GEM-PROs), wrappers to popular third-party programs to compute associated protein properties, and methods to visualize and annotate structures directly in Jupyter notebooks, thus lowering the barrier of linking 3D structural data with established systems workflows...
February 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29444169/monitoring-chest-compression-quality-during-cardiopulmonary-resuscitation-proof-of-concept-of-a-single-accelerometer-based-feedback-algorithm
#5
Digna María González-Otero, Jesus María Ruiz, Sofía Ruiz de Gauna, Jose Julio Gutiérrez, Mohamud Daya, James Knox Russell, Izaskun Azcarate, Mikel Leturiondo
BACKGROUND: The use of real-time feedback systems to guide rescuers during cardiopulmonary resuscitation (CPR) significantly contributes to improve adherence to published resuscitation guidelines. Recently, we designed a novel method for computing depth and rate of chest compressions relying solely on the spectral analysis of chest acceleration. That method was extensively tested in a simulated manikin scenario. The purpose of this study is to report the results of this method as tested in human out-of-hospital cardiac arrest (OHCA) cases...
2018: PloS One
https://www.readbyqxmd.com/read/29444130/-are-you-gonna-publish-that-peer-reviewed-publication-outcomes-of-doctoral-dissertations-in-psychology
#6
Spencer C Evans, Christina M Amaro, Robyn Herbert, Jennifer B Blossom, Michael C Roberts
If a doctoral dissertation represents an original investigation that makes a contribution to one's field, then dissertation research could, and arguably should, be disseminated into the scientific literature. However, the extent and nature of dissertation publication remains largely unknown within psychology. The present study investigated the peer-reviewed publication outcomes of psychology dissertation research in the United States. Additionally, we examined publication lag, scientific impact, and variations across subfields...
2018: PloS One
https://www.readbyqxmd.com/read/29444064/optimized-random-phase-only-holograms
#7
Alejandro Velez Zea, John Fredy Barrera Ramirez, Roberto Torroba
We propose a simple and efficient technique capable of generating Fourier phase only holograms with a reconstruction quality similar to the results obtained with the Gerchberg-Saxton (G-S) algorithm. Our proposal is to use the traditional G-S algorithm to optimize a random phase pattern for the resolution, pixel size, and target size of the general optical system without any specific amplitude data. This produces an optimized random phase (ORAP), which is used for fast generation of phase only holograms of arbitrary amplitude targets...
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29443897/structured-kernel-subspace-learning-for-autonomous-robot-navigation
#8
Eunwoo Kim, Sungjoon Choi, Songhwai Oh
This paper considers two important problems for autonomous robot navigation in a dynamic environment, where the goal is to predict pedestrian motion and control a robot with the prediction for safe navigation. While there are several methods for predicting the motion of a pedestrian and controlling a robot to avoid incoming pedestrians, it is still difficult to safely navigate in a dynamic environment due to challenges, such as the varying quality and complexity of training data with unwanted noises. This paper addresses these challenges simultaneously by proposing a robust kernel subspace learning algorithm based on the recent advances in nuclear-norm and l 1 -norm minimization...
February 14, 2018: Sensors
https://www.readbyqxmd.com/read/29443893/a-modular-iot-platform-for-real-time-indoor-air-quality-monitoring
#9
Mohieddine Benammar, Abderrazak Abdaoui, Sabbir H M Ahmad, Farid Touati, Abdullah Kadri
The impact of air quality on health and on life comfort is well established. In many societies, vulnerable elderly and young populations spend most of their time indoors. Therefore, indoor air quality monitoring (IAQM) is of great importance to human health. Engineers and researchers are increasingly focusing their efforts on the design of real-time IAQM systems using wireless sensor networks. This paper presents an end-to-end IAQM system enabling measurement of CO₂, CO, SO₂, NO₂, O₃, Cl₂, ambient temperature, and relative humidity...
February 14, 2018: Sensors
https://www.readbyqxmd.com/read/29443890/embedded-disposable-functionalized-electrochemical-biosensor-with-a-3d-printed-flow-cell-for-detection-of-hepatic-oval-cells-hocs
#10
Samar Damiati, Martin Peacock, Stefan Leonhardt, Laila Damiati, Mohammed A Baghdadi, Holger Becker, Rimantas Kodzius, Bernhard Schuster
Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describes the development of a 3D-printed continuous flow system and exploits disposable screen-printed electrodes for the rapid detection of HOCs that over-express the OV6 marker on their membrane. Multiwall carbon nanotube (MWCNT) electrodes have a chitosan film that serves as a scaffold for the immobilization of oval cell marker antibodies (anti-OV6-Ab), which enhance the sensitivity of the biomarker and makes the designed sensor specific for oval cells...
February 14, 2018: Genes
https://www.readbyqxmd.com/read/29443814/danger-signals-in-the-icu
#11
Edward J Schenck, Kevin C Ma, Santosh B Murthy, Augustine M K Choi
OBJECTIVES: Sterile and infectious critical illnesses often result in vasoplegic shock and a robust systemic inflammatory response that are similar in presentation. The innate immune system is at the center of the response to both infectious and traumatic insults. Damage-associated molecular patterns are small molecules that are released from stressed or dying cells. Damage-associated molecular patterns activate pattern recognition receptors and coordinate the leading edge of the innate immune response...
February 13, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29443739/effects-of-exercise-on-secretion-transport-inflammation-and-quality-of-life-in-patients-with-noncystic-fibrosis-bronchiectasis-protocol-for-a-randomized-controlled-trial
#12
Daniele Oliveira Dos Santos, Hugo Celso Dutra de Souza, José Antônio Baddini-Martinez, Ercy Mara Cipulo Ramos, Ada Clarice Gastaldi
BACKGROUND: Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes. The most frequent characteristic is the increase in bronchial mucus production resulting in slower transport and damage to the mucociliary transport. AIMS: To evaluate the effects of exercise on mucus transport, inflammation, and resistance of the respiratory and autonomic nervous systems and subsequent effects on quality of life in patients with bronchiectasis who are enrolled in a pulmonary rehabilitation program...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443725/pediatric-anesthesia-after-the-anaesthesia-practice-in-children-observational-trial-study-who-should-do-it
#13
Walid Habre
PURPOSE OF REVIEW: This review highlights the requirements for harmonization of training, certification and continuous professional development and discusses the implications for anesthesia management of children in Europe. RECENT FINDINGS: A large prospective cohort study, Anaesthesia PRactice In Children Observational Trial (APRICOT), revealed a high incidence of perioperative severe critical events and a large variability of anesthesia practice across 33 European countries...
February 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29443719/the-time-is-now-using-graduates-practice-data-to-drive-medical-education-reform
#14
Marc M Triola, Richard E Hawkins, Susan E Skochelak
Medical educators are not yet taking full advantage of the publicly available clinical practice data published by federal, state, and local governments, which can be attributed to individual physicians and evaluated in the context of where they attended medical school and residency training. Understanding how graduates fare in actual practice, both in terms of the quality of the care they provide and the clinical challenges they face, can aid educators in taking an evidence-based approach to medical education...
February 13, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29443647/system-level-health-care-integration-and-the-costs-of-cancer-care-across-the-disease-continuum
#15
Deborah R Kaye, Hye Sung Min, Edward C Norton, Zaojun Ye, Jonathan Li, James M Dupree, Chad Ellimoottil, David C Miller, Lindsey A Herrel
PURPOSE: Policy reforms in the Affordable Care Act encourage health care integration to improve quality and lower costs. We examined the association between system-level integration and longitudinal costs of cancer care. METHODS: We used linked SEER-Medicare data to identify patients age 66 to 99 years diagnosed with prostate, bladder, esophageal, pancreatic, lung, liver, kidney, colorectal, breast, or ovarian cancer from 2007 to 2012. We attributed each patient to one or more phases of care (ie, initial, continuing, and end of life) according to time from diagnosis until death or end of study interval...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29443646/electronic-medical-record-based-radiation-oncology-toxicity-recording-instrument-aids-benchmarking-and-quality-improvement-in-the-clinic
#16
Kevin Albuquerque, Kellie Rodgers, Ann Spangler, Asal Rahimi, DuWayne Willett
PURPOSE: The on-treatment visit (OTV) for radiation oncology is essential for patient management. Radiation toxicities recorded during the OTV may be inconsistent because of the use of free text and the lack of treatment site-specific templates. We developed a radiation oncology toxicity recording instrument (ROTOX) in a health system electronic medical record (EMR). Our aims were to assess improvement in documentation of toxicities and to develop clinic toxicity benchmarks. METHODS: A ROTOX that was based on National Cancer Institute Common Terminology Criteria for Adverse Events (version 4...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29443386/technical-note-error-metrics-for-estimating-the-accuracy-of-needle-instrument-placement-during-transperineal-mr-us-guided-prostate-interventions
#17
Ester Bonmati, Yipeng Hu, Barbara Villarini, Rachael Rodell, Paul Martin, Lianghao Han, Ian Donaldson, Hashim U Ahmed, Caroline M Moore, Mark Emberton, Dean C Barratt
PURPOSE: Image-guided systems that fuse magnetic resonance imaging (MRI) with three-dimensional (3D) ultrasound (US) images for performing targeted prostate needle biopsy and minimally-invasive treatments for prostate cancer are of increasing clinical interest. To date, a wide range of different accuracy estimation procedures and error metrics have been reported, which makes comparing the performance of different systems difficult. METHODS: A set of 9 measures are presented to assess the accuracy of MRI-US image registration, needle positioning, needle guidance, and overall system error, with the aim of providing a methodology for estimating the accuracy of instrument placement using a MR/US-guided transperineal approach...
February 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29443103/paradigms-of-lower-extremity-electrical-stimulation-training-after-spinal-cord-injury
#18
Ashraf S Gorgey, Refka E Khalil, Robert M Lester, Gary A Dudley, David R Gater
Skeletal muscle atrophy, increased adiposity and reduced physical activity are key changes observed after spinal cord injury (SCI) and are associated with numerous cardiometabolic health consequences. These changes are likely to increase the risk of developing chronic secondary conditions and impact the quality of life in persons with SCI. Surface neuromuscular electrical stimulation evoked resistance training (NMES-RT) was developed as a strategy to attenuate the process of skeletal muscle atrophy, decrease ectopic adiposity, improve insulin sensitivity and enhance mitochondrial capacity...
February 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29443097/variations-on-negative-stain-electron-microscopy-methods-tools-for-tackling-challenging-systems
#19
Charlotte A Scarff, Martin J G Fuller, Rebecca F Thompson, Matthew G Iadaza
Negative stain electron microscopy (EM) allows relatively simple and quick observation of macromolecules and macromolecular complexes through the use of contrast enhancing stain reagent. Although limited in resolution to a maximum of ~18 - 20 Å, negative stain EM is useful for a variety of biological problems and also provides a rapid means of assessing samples for cryo-electron microscopy (cryo-EM). The negative stain workflow is straightforward method; the sample is adsorbed onto a substrate, then a stain is applied, blotted, and dried to produce a thin layer of electron dense stain in which the particles are embedded...
February 6, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29443089/a-simple-method-for-isolation-of-soybean-protoplasts-and-application-to-transient-gene-expression-analyses
#20
Faqiang Wu, Yoshie Hanzawa
Soybean (Glycine max (L.) Merr.) is an important crop species and has become a legume model for the studies of genetic and biochemical pathways. Therefore, it is important to establish an efficient transient gene expression system in soybean. Here, we report a simple protocol for the preparation of soybean protoplasts and its application for transient functional analyses. We found that young unifoliate leaves from soybean seedlings resulted in large quantities of high quality protoplasts. By optimizing a PEG-calcium-mediated transformation method, we achieved high transformation efficiency using soybean unifoliate protoplasts...
January 25, 2018: Journal of Visualized Experiments: JoVE
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