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https://www.readbyqxmd.com/read/29232471/cytoreductive-surgery-for-ovarian-cancer-quality-assessment
#1
A H Brand, P A DiSilvestro, J Sehouli, J S Berek
Surgery is the cornerstone of treatment of ovarian cancer. Given the importance of achieving no or minimal macroscopic residual disease at primary surgery, performing an assessment of the quality of ovarian cancer surgery is crucial. Assessing the quality of care and surgical outcome allows us to establish baseline information, set standards of care and clear priorities, enable benchmarking against peers, and sustain quality improvement. We know that suboptimal care exists and variation in outcomes results...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232467/immunotherapy-in-ovarian-cancer
#2
K Odunsi
Immunological destruction of tumors is a multistep, coordinated process that can be modulated or targeted at several critical points to elicit tumor rejection. These steps in the cancer immunity cycle include: (i) generation of sufficient numbers of effector T cells with high avidity recognition of tumor antigens in vivo; (ii) trafficking and infiltration into the tumor; (iii) overcoming inhibitory networks in the tumor microenvironment; (iv) direct recognition of tumor antigens and generation of an effector anti-tumor response; and (v) persistence of the anti-tumor T cells...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232377/association-between-infrastructure-and-observed-quality-of-care-in-4-healthcare-services-a-cross-sectional-study-of-4-300-facilities-in-8-countries
#3
Hannah H Leslie, Zeye Sun, Margaret E Kruk
BACKGROUND: It is increasingly apparent that access to healthcare without adequate quality of care is insufficient to improve population health outcomes. We assess whether the most commonly measured attribute of health facilities in low- and middle-income countries (LMICs)-the structural inputs to care-predicts the clinical quality of care provided to patients. METHODS AND FINDINGS: Service Provision Assessments are nationally representative health facility surveys conducted by the Demographic and Health Survey Program with support from the US Agency for International Development...
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29232268/pelvic-organ-prolapse-repair-using-the-uphold-vaginal-support-system-5-year-follow-up
#4
Päivi Rahkola-Soisalo, Tomi S Mikkola, Daniel Altman, Christian Falconer
OBJECTIVE: This study aimed to assess the long-term (5 years) outcomes of the Uphold Vaginal Support System for symptomatic vaginal apical prolapse with or without anterior colporraphy. METHODS: In total, 164 (81.2%) of 202 women operated on in 24 centers were reached for follow-up. Outcomes were assessed by using the Pelvic Organ Prolapse Quantification, the Pelvic Floor Distress Inventory 20, and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire questionnaires...
December 11, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29232108/biocompatible-electroactive-tetra-aniline-conjugated-peptide-nanofibers-for-neural-differentiation
#5
Idil Arioz, Ozlem Erol, Gokhan Bakan, F Begum Dikecoglu, Ahmet Emin Topal, Mustafa Urel, Aykutlu Dana, Ayse B Tekinay, Mustafa O Guler
Peripheral nerve injuries cause devastating problems for the quality of the patients' lives and regeneration following a damage to the peripheral nervous system is limited depending on the degree of the damage. Use of nanobiomaterials can provide therapeutic approaches for the treatment of peripheral nerve injuries. Electroactive biomaterials, in particular, can provide a promising cure for the regeneration of nerve defects. Here, a supramolecular electroactive nanosystem with tetra(aniline) (TA) containing peptide nanofibers was developed and utilized for nerve regeneration...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29232099/the-effect-of-graphene-ec-on-ag-nw-based-transparent-film-heaters-optimizing-the-stability-and-heat-dispersion-of-film
#6
Minghui Cao, Minqiang Wang, Le Li, Hengwei Qiu, Zhi Yang
In order to optimize the performance of silver nanowire (Ag NW) film heaters and explore the effect of graphene on the film, we introduced the poly (3, 4-ethylenedioxythiophene): poly (4-styrenesulfonate) (PEDOT: PSS) and graphene modified with ethyl cellulose (graphene-EC) into the film in this paper. The high quality and well-dispersed graphene-EC was synthesized with graphene obtained by electrochemical exfoliation as precursor. The transparent film heaters were fabricated via spin-coating. With the assistance of graphene-EC, the stability of the film heaters was greatly improved and the conductivity was optimized by adjusting Ag NW concentration...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29232069/medicare-program-cy-2018-updates-to-the-quality-payment-program-and-quality-payment-program-extreme-and-uncontrollable-circumstance-policy-for-the-transition-year-final-rule-with-comment-period-and-interim-final-rule-with-comment-period
#7
(no author information available yet)
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) established the Quality Payment Program for eligible clinicians. Under the Quality Payment Program, eligible clinicians can participate via one of two tracks: Advanced Alternative Payment Models (APMs); or the Merit-based Incentive Payment System (MIPS). We began implementing the Quality Payment Program through rulemaking for calendar year (CY) 2017. This final rule with comment period provides updates for the second and future years of the Quality Payment Program...
November 16, 2017: Federal Register
https://www.readbyqxmd.com/read/29232015/constant-vigilance-plant-functions-guarded-by-resistance-proteins
#8
Jianbin Su, Benjamin J Spears, Sang Hee Kim, Walter Gassmann
Unlike animals, plants do not have an adaptive immune system and have instead evolved sophisticated and multi-layered innate immune mechanisms. To overcome plant immunity, pathogens secrete a diverse array of effectors into the apoplast and virtually all cellular compartments in order to dampen immune signaling and interfere with plant functions. Here we describe the scope of the arms race throughout the cell and summarize various strategies used by both plants and pathogens. Through studying the ongoing evolutionary battle between plants and key pathogens, we may yet uncover potential ways to achieve the ultimate goal of engineering broad-spectrum resistant crops without affecting food quality or productivity...
December 12, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29231969/patient-reported-outcomes-enhance-the-survival-prediction-of-traditional-disease-risk-classifications-an-international-study-in-patients-with-myelodysplastic-syndromes
#9
Fabio Efficace, Francesco Cottone, Gregory Abel, Pasquale Niscola, Gianluca Gaidano, Franck Bonnetain, Amelie Anota, Giovanni Caocci, Angel Cronin, Luana Fianchi, Massimo Breccia, Reinhard Stauder, Uwe Platzbecker, Giuseppe A Palumbo, Mario Luppi, Rosangela Invernizzi, Micaela Bergamaschi, Lorenza Borin, Anna Angela Di Tucci, Huiyong Zhang, Mirjam Sprangers, Marco Vignetti, Franco Mandelli
BACKGROUND: Current prognostic systems for myelodysplastic syndromes (MDS) are based on clinical, pathologic, and laboratory indicators. The objective of the current study was to develop a new patient-centered prognostic index for patients with advanced MDS by including self-reported fatigue severity into a well-established clinical risk classification: the International Prognostic Scoring System (IPSS). METHODS: A total of 469 patients with advanced (ie, IPSS intermediate-2 or high-risk) MDS were analyzed...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29231890/development-and-verification-of-a-novel-robot-integrated-fringe-projection-3d-scanning-system-for-large-scale-metrology
#10
Hui Du, Xiaobo Chen, Juntong Xi, Chengyi Yu, Bao Zhao
Large-scale surfaces are prevalent in advanced manufacturing industries, and 3D profilometry of these surfaces plays a pivotal role for quality control. This paper proposes a novel and flexible large-scale 3D scanning system assembled by combining a robot, a binocular structured light scanner and a laser tracker. The measurement principle and system construction of the integrated system are introduced. A mathematical model is established for the global data fusion. Subsequently, a robust method is introduced for the establishment of the end coordinate system...
December 12, 2017: Sensors
https://www.readbyqxmd.com/read/29231885/development-of-a-sequential-injection-analysis-system-for-the-determination-of-saccharin
#11
Budi Wibowotomo, Jong-Bang Eun, Jong Il Rhee
Saccharin is a powerfully sweet nonnutritive sweetener that has been approved for food-processing applications within the range of 100-1200 mg/kg. A simple, rapid, and cost-effective sequential injection analysis (SIA) technique was developed to determine the saccharin level. This method is based on the reaction of saccharin with p-chloranil in an ethanol medium with a hydrogen peroxide (H₂O₂) acceleration, and the resultant violet-red compound was detected using a UV-Vis spectrophotometer at λmax = 420 nm...
December 12, 2017: Sensors
https://www.readbyqxmd.com/read/29231837/the-primary-health-care-system-in-china
#12
REVIEW
Xi Li, Jiapeng Lu, Shuang Hu, K K Cheng, Jan De Maeseneer, Qingyue Meng, Elias Mossialos, Dong Roman Xu, Winnie Yip, Hongzhao Zhang, Harlan M Krumholz, Lixin Jiang, Shengshou Hu
China has made remarkable progress in strengthening its primary health-care system. Nevertheless, the system still faces challenges in structural characteristics, incentives and policies, and quality of care, all of which diminish its preparedness to care for a fifth of the world's population, which is ageing and which has a growing prevalence of chronic non-communicable disease. These challenges include inadequate education and qualifications of its workforce, ageing and turnover of village doctors, fragmented health information technology systems, a paucity of digital data on everyday clinical practice, financial subsidies and incentives that do not encourage cost savings and good performance, insurance policies that hamper the efficiency of care delivery, an insufficient quality measurement and improvement system, and poor performance in the control of risk factors (such as hypertension and diabetes)...
December 9, 2017: Lancet
https://www.readbyqxmd.com/read/29231672/medicare-program-hospital-outpatient-prospective-payment-and-ambulatory-surgical-center-payment-systems-and-quality-reporting-programs-final-rule-with-comment-period
#13
(no author information available yet)
This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) and the Medicare ambulatory surgical center (ASC) payment system for CY 2018 to implement changes arising from our continuing experience with these systems. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare services paid under the OPPS and those paid under the ASC payment system. In addition, this final rule with comment period updates and refines the requirements for the Hospital Outpatient Quality Reporting (OQR) Program and the ASC Quality Reporting (ASCQR) Program...
November 13, 2017: Federal Register
https://www.readbyqxmd.com/read/29231538/-establishing-the-acupuncture-moxibustion-clinical-trial-registry-and-improving-the-transparence-of-clinical-trials-of-acupuncture-and-moxibustion
#14
Yali Liu, Liyun He, Jia Liu, Xingyue Yang, Dongning Yan, Xin Wang, Lin Luo, Hongjiao Li, Shiyan Yan, Tiancai Wen, Wenjing Bai, Taixiang Wu, Baoyan Liu
As a kind of intervention measures of traditional Chinese medicine, acupuncture-moxibustion is highly adopted on global clinical practice. Even though the global clinical trial registration system was established more than 10 years ago, the proportion of acupuncture-moxibustion clinical trial registration is still very low; and it is very problematic on the methodological quality and report quality in the published acupuncture-moxibustion clinical trials. In order to manage particularly the acupuncture-moxibustion clinical trials, China Academy of Chinese Medical Sciences, collaborated with China Association of Acupuncture and Moxibustion and World Federation of Acupuncture Societies, established the Acupuncture-Moxibustion Clinical Trail Registry (AMCTR)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231243/neuromuscular-electrical-stimulation-nmes-for-patellofemoral-pain-syndrome
#15
REVIEW
Ana Luiza C Martimbianco, Maria Regina R Torloni, Brenda Ng Andriolo, Gustavo Jm Porfírio, Rachel Riera
BACKGROUND: Patellofemoral pain syndrome, now generally referred to as patellofemoral pain (PFP), is one of the most common orthopaedic disorders, characterised by pain in the anterior or retropatellar knee region. Neuromuscular electrical stimulation (NMES) has been proposed generally as a complementary treatment, associated with other interventions such as exercise, or as a single treatment to increase muscle force, reduce knee pain, and improve function. OBJECTIVES: To assess the effects (benefits and harms) of neuromuscular electrical stimulation for people with patellofemoral pain...
December 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29231151/in-vitro-effect-of-various-cryoprotectants-on-the-semen-quality-of-endangered-oravka-chicken
#16
Andrea Svoradová, Lenka Kuželová, Jaromír Vašíček, Andrej Baláži, Emília Hanusová, Peter Chrenek
We aimed to compare the effect of three different permeating cryoprotectants on the post-thaw spermatozoa quality. Pooled semen from Oravka cock line (n = 6) was diluted in Kobidil+ extender and frozen in cryoprotectant solutions containing 8% dimethylsulfoxide (DMSO), 8% ethylene glycol (EG) or 8% glycerol (GL) in liquid nitrogen vapours before being plunged into the liquid nitrogen. Spermatozoa motility parameters were assessed in vitro after freezing-thawing by a computer-assisted semen analysis (CASA) system and viability status was examined using fluorescent probes...
December 12, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29231144/qsar-of-natural-sesquiterpene-lactones-as-inhibitors-of-myb-dependent-gene-expression
#17
Gloria Castellano, Lucia Redondo, Francisco Torrens
Protein c-Myb is a therapeutic target. Some sesquiterpene lactones suppress Myb-dependent gene expression, which results in a mechanism for their potential anti-cancer activity. Database ChEMBL is representative of lactones for physicochemical and physiochemical properties. Data presented for 31 natural lactones are discussed in terms of quantitative structure-activity relationships, which objective is to predict inhibitors of Myb-induced gene expression. Several constitutional descriptors are related to structure-activity...
December 11, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29231070/building-the-ontario-surgical-oncology-program
#18
Terrence Sullivan, Jonathan Irish
From the 1940s onward the establishment of an increasing number of cancer centres in Ontario concentrated predominantly on radiation and systemic therapy. Increasing attention to the organization of cancer surgery services in Ontario over the last 3 decades through measures led by Cancer Care Ontario has resulted in building a progressive provincial and regional surgical oncology network. These networks are rooted in leadership mobilization and have used quality data and best evidence to promote the elaboration of communities of practice to achieve better outcomes...
January 1, 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/29230871/prospective-motion-correction-enables-highest-resolution-time-of-flight-angiography-at-7t
#19
Hendrik Mattern, Alessandro Sciarra, Frank Godenschweger, Daniel Stucht, Falk Lüsebrink, Georg Rose, Oliver Speck
PURPOSE: Higher magnetic field strengths enable time-of-flight (TOF) angiography with higher resolution to depict small-vessel pathologies. However, this potential is limited by the subject's ability to remain motionless. Even small-scale, involuntary motion can degrade vessel depiction, thus limiting the effective resolution. The aim of this study was to overcome this resolution limit by deploying prospectively motion-corrected (PMC) TOF. METHODS: An optical, marker-based, in-bore tracking system was used to update the imaging volume prospectively according to the subject's head motion...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29230802/measurement-properties-of-instruments-that-assess-participation-in-young-people-with-autism-spectrum-disorder-a-systematic-review
#20
REVIEW
Francesca Lami, Kristine Egberts, Alexandra Ure, Rowena Conroy, Katrina Williams
AIM: To systematically review the measurement properties of instruments assessing participation in young people with autism spectrum disorder (ASD). METHOD: A search was performed in MEDLINE, PsycINFO, and PubMed combining three constructs ('ASD', 'test of participation', 'measurement properties'). Results were restricted to articles including people aged 6 to 29 years. The 2539 identified articles were independently screened by two reviewers. For the included articles, data were extracted using standard forms and their risk of bias was assessed...
December 12, 2017: Developmental Medicine and Child Neurology
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