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nephron sparing surgery

F-H Liu, W-J Ni, G-K Wang, J-J Zhang
Renal ischemia/reperfusion (I/R) damage may arise due to nephron sparing surgery in patient with a solitary kidney of restricted renal parenchymas. Apoptosis, inflammation and oxidative stress play a significant role in the expansion of renal dysfunction following renal I/R. The aim of the current investigation was to particularize the potential effect of curcumin against hypoxia induced renal injury. The albino Wistar rats divided into groups and each group contains six rats. They groups are normal control; disease control; curcumin (5 mg/kg per day) and another group orally treated with curcumin (10 mg/kg per day) for two weeks before induction of renal I/R...
September 30, 2016: Cellular and Molecular Biology
Ahmad Alenezi, Giacomo Novara, Alexander Mottrie, Salah Al-Buheissi, Omer Karim
Nephron-sparing surgery for the removal of small renal masses delivers equivalent oncological outcomes and better functional outcomes compared with those associated with radical nephrectomy. All contemporary partial nephrectomy techniques including open, laparoscopic and robotic approaches involve the use of hilar clamping in order to facilitate haemostasis, and to enable accurate tumour excision and parenchymal reconstruction. Zero ischaemia was subsequently introduced as a technique to eliminate the renal ischaemia induced by hilar clamping...
October 18, 2016: Nature Reviews. Urology
Selahattin Çaliskan, Emrah Özsoy, Selçuk Kaba, Orhan Koca, Metin Isak Öztürk
INTRODUCTION: Xanthogranulomatous pyelonephritis is a chronic destructive granulomatous inflammation of the kidney. This pathology was firstly described in 1916 and a small number of patient series were reported in the literature. In this study, we aimed to report the patients with xanthogranulomatous pyelonephritis in our nephrectomy cases. METHODS: The patients who underwent nephrectomy and were diagnosed with xanthogranulomatous pyelonephritis in our hospital database were reviewed retrospectively...
October 2016: Archives of Iranian Medicine
Roberto Iglesias Lopes, Jessica Ming, Martin A Koyle, Ronald Grant, Adriana Fonseca, Armando J Lorenzo
OBJECTIVE: To describe the experience and technique of zero-ischemia laparoscopic-assisted partial nephrectomy at The Hospital for Sick Children, as an alternative to the traditional open approach for nephron sparing surgery in selected children with Wilms' tumors (WT). MATERIALS AND METHODS: Patients with diagnosis of WT treated with neoadjuvant chemotherapy and who underwent laparoscopic-assisted nephron-sparing surgery at the Hospital for Sick Children from 2012-2016 were identified and charts reviewed retrospectively...
October 6, 2016: Urology
Pierre Bigot, Jean-Christophe Bernhard, Vincent Flamand, Inderbir Gill, Grégory Verhoest, Jean Baptiste Beauval, François Xavier Nouhaud, Evren Suer, Guillaume Ploussard, Jean François Hetet, Jérôme Rigaud, Eduard Baco, Stéphane Larré, Philippe Sebe, Nicolas Koutlidis, Aurélien Descazeaud, Masatoshi Eto, Arnaud Doerfler, Morgan Roupret, Nam Son Vuong, Boris Reix, Toru Matsugasumi, Adnan El Bakri, Laurence Albiges, Michel Soulié, Jean-Jacques Patard, Arnaud Méjean, Karim Bensalah
OBJECTIVE: To evaluate the oncologic outcomes of nephron-sparing surgery (NSS) for localized chromophobe renal cell carcinoma (cRCC). MATERIAL AND METHODS: We performed a multicenter international study involving the French Network for Research on Kidney Cancer (UroCCR) and 5 international teams. Data from 808 patients treated with NSS between 2004 and 2014 for non-clear cell RCCs were analyzed. RESULTS: We included 234 patients with cRCC...
September 27, 2016: Urologic Oncology
X B Wu, G T Zhang, F Zhang, W D Gan, G X Liu, X G Li, S W Zhang, H Q Guo
Objective: To explore the safety and clinical efficacy of partial nephrectomy for solitary kidney tumor. Methods: Twenty patients with a functional or anatomic solitary kidney who underwent nephron-sparing surgery for one or more renal masses were retrospectively analyzed. There were 15 male and 5 female patients with mean age of 63 years.Patients were divided into open partial nephrectomy(OPN) group and laparoscopic partial nephrectomy(LPN) group, the two groups were followed up.Demographic and clinical characteristics were analyzed using student t-test for continuous variables, and the χ(2) test for categorical variables...
October 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
C Z Kong, S Q Du
In recent years the incidence of small renal carcinoma is increasing, and nephron sparing surgery(NSS) becomes the mainstream to treat it. NSS is considered based on comprehensive analysis: the imaging examination, systemic evaluation of the patients, and the indications of NSS. There are three common surgical approaches: intraperitoneal approach, retroperitoneal approach and the joint approach. It is recommended to do intraoperative frozen pathology. If the edge is positive, it is better to cut a deeper layer of the tissue around the renal tumor or transform to radical nephrectomy...
October 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Kristýna Procházková, Michael Staehler, Ivan Trávníček, Tomáš Pitra, Viktor Eret, Tomáš Ürge, Lada Eberlová, Milena Roušarová, Petr Hošek, Zdeněk Chudáček, Jiří Ferda, Ondřej Hes, Milan Hora
AIM: Papillary renal cell carcinoma type 1 (pRCC1) represents the second most common type of malignant renal epithelial tumour. The origin of its characteristic appearance, its growth mechanism, and the long-term efficiency of its surgical treatment remain uncertain. Our aim was to determine typical characteristics of surgically treated pRCC1. METHODS: pRCC1 was verified in 83 of 1,629 (5.1%) kidney tumours surgically treated in the period of January 2007-January 2016...
September 30, 2016: Urologia Internationalis
F Kleinclauss, R Thuret, T Murez, M O Timsit
OBJECTIVE: To review epidemiology and management of urologic neoplasms in renal transplant candidates and recipients. MATERIAL AND METHODS: Relevant publications were identified through Medline ( and Embase ( database using the following keywords, alone or in association, "neoplasms"; "prostate cancer"; "renal carcinoma"; "renal transplantation"; "transitional carcinoma"; "waiting list". Articles were selected according to methods, language of publication and relevance...
September 21, 2016: Progrès en Urologie
Matthew J Watson, Abhinav Sidana, Annerleim Walton-Diaz, M Minhaj Siddiqui, Ryan Andrew Hankins, Gennady Bratslavsky, W Marston Linehan, Adam Metwali
INTRODUCTION: Multifocal and hereditary kidney cancers often require repeated ipsilateral nephron sparing procedures with higher blood loss and complication rates when compared to first time renal surgery. Consequently, many surgeons avoid minimally invasive techniques in the setting. We present the characteristics, complications and short-term renal functional outcomes of patients who underwent a repeat robotic partial nephrectomy (rRPNx). MATERIALS AND METHODS: A database was retrospectively reviewed to identify patients who underwent robotic partial nephrectomies between January 2007 and December 2013...
September 20, 2016: Journal of Endourology
Jihad H Kaouk, Ercan Malkoç
Nephron sparing surgery (NSS) is the gold standard treatment option for patients with a solitary kidney in order to preserve renal function. Open partial nephrectomy (OPN) has been long considered the standard care for NSS. Robotic partial nephrectomy (RPN) is being gradually used more commonly even for solitary kidney and complex tumors. There was no difference between RPN and OPN regarding the rate of intraoperative-postoperative complications and positive surgical margin (PSM) (RPN: 7.5%, OPN: 8%) for patients with solitary kidney who underwent partial nephrectomy for small renal masses...
September 2016: Turkish Journal of Urology
T Smektala, A Goląb, M Królikowski, M Slojewski
OBJECTIVE: The aim of this brief report was to present and evaluate workflow of preparation of lowcost individual silicone replicas of kidneys for laparoscopic training and surgical simulation of difficult nephron sparing surgeries. METHODS: The work flow consists of four steps: 1.Image segmentation; 2.Casting mould designing; 3.Manufacturing of casting mould; 4.Silicone replica casting. To evaluate the cost and time required to execute the presented method, authors prepared 5 silicone models for 5 consecutive patients undergoing laparoscopic kidney tumorectomy due to renal cell cancer...
September 2016: Archivos Españoles de Urología
Robert H Blackwell, Belinda Li, Zachary Kozel, Zhiling Zhang, Juping Zhao, Wen Dong, Sarah E Capodice, Gregory Barton, Arpeet Shah, Jessica J Wetterlin, Marcus L Quek, Steven C Campbell, Gopal N Gupta
OBJECTIVE: To compare the surgical precision for optimizing nephron-mass preservation of tumor enucleation (TE) vs standard partial nephrectomy (SPN), with primary focus on functional outcomes. TE is presumed to optimize preservation of parenchymal mass and function but this has not yet been rigorously studied and quantified. MATERIALS AND METHODS: Robotic partial nephrectomy patients who had appropriate pre- and postoperative studies for analysis of parenchymal mass preservation specific to the operated kidney were included...
September 7, 2016: Urology
Lucas Wauters, Thomas Billiet, Konstantinos Papamichael, Vera Ballet, Steven Joniau, Patrick Verschueren, Geert Silversmit, Gert Van Assche, Séverine Vermeire, Marc Ferrante
OBJECTIVE: We aimed to study the risk of renal cell carcinoma (RCC) with anti-tumor necrosis factor (anti-TNF) therapy in inflammatory bowel disease (IBD) and rheumatic diseases (RD) and calculate standardized incidence ratios (SIRs) in IBD. MATERIALS AND METHODS: This was a retrospective case-control and cohort study spanning 25 years, including IBD and RD patients with a diagnosis of RCC (1990-2014) identified through the electronic database of a tertiary referral center...
September 3, 2016: European Journal of Gastroenterology & Hepatology
M Pilar Laguna
No abstract text is available yet for this article.
September 2016: Journal of Urology
Murat Binbay, Emrah Yuruk, Burak Ucpinar, Zerrin Binbay, Aykut Colakerol, Ahmet Yaser Muslumanoglu
BACKGROUND: The incidence of renal-cell carcinoma (RCC) is low during pregnancy. There are different approaches for timing of surgery and treatment modalities for RCC in pregnant women in the literature. To our knowledge, this is the first laparoscopic partial nephrectomy case in a pregnant woman. CASE PRESENTATION: Herein, we present a 34-year-old woman with a renal mass at her 14th gestational week. She was admitted to our clinic after a right renal mass was incidentally diagnosed during routine antenatal ultrasonography...
2016: J Endourol Case Rep
Chang Ho Jeon, Nak Jong Seong, Chang Jin Yoon, Seok-Soo Byun, Sang Eun Lee
BACKGROUND: With the wider application of nephron-sparing surgery, there has been an increase in the occurrence of postoperative hemorrhage. However, despite such an increase, there are only a limited number of reports regarding renal artery embolization (RAE) for the management of postoperative bleeding after nephron-sparing surgery, especially after robot-assisted laparoscopic partial nephrectomy (RALPN). PURPOSE: To evaluate the safety and clinical efficacy of transcatheter RAE for postoperative hemorrhage after open partial nephrectomy (OPN) and RALPN...
August 2016: Acta Radiologica Open
Peter A Caputo, Homayoun Zargar, Daniel Ramirez, Hiury S Andrade, Oktay Akca, Tianming Gao, Jihad H Kaouk
BACKGROUND: The traditional treatment for a cT1b renal tumor has been radical nephrectomy. However, recent guidelines have shifted towards partial nephrectomy (PN) in selected patients with cT1b renal tumors. Furthermore, practitioners have extended the role of cryoablation (CA) to treat cT1b tumors in selected patients. OBJECTIVE: To evaluate the efficacy of CA compared to PN for cT1b renal tumors. DESIGN, SETTING, AND PARTICIPANTS: We performed a retrospective review of patients who underwent either renal CA (laparoscopic or percutaneous) or PN (robot-assisted) for a cT1b renal mass (>4cm and ≤7cm) between November 1999 and August 2014...
August 24, 2016: European Urology
Julie C Wang, Weil R Lai, Elizabeth J Traore, James Liu, Andrew B Sholl, Sree Harsha Mandava, Michael M Maddox, Gregory C Mitchell, Sarayuth Viriyasiripong, Jonathan L Silberstein, Rick Kittles, Benjamin R Lee
PURPOSE: To identify variations in renal function and histology between Caucasian Americans (CA) and African Americans (AA) undergoing robotic nephron-sparing surgery (NSS). METHODS: A retrospective chart review was performed on patients who underwent NSS. Multivariate analysis identified factors affecting postoperative estimated glomerular filtration rate (eGFR). Histology was re-reviewed by pathology to confirm papillary type. RESULTS: A total of 331 patients underwent NSS: CA (n = 212), AA (n = 105), Hispanic (n = 10), and other (n = 4)...
July 22, 2016: Clinical Genitourinary Cancer
Nirmish Singla, Ryan Hutchinson, Ahmed Haddad, Arthur Sagalowsky, Yair Lotan, Vitaly Margulis
INTRODUCTION: To compare renal function changes after radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC) based on the presence of preoperative hydronephrosis. MATERIALS AND METHODS: Clinicopathologic data of 208 patients with UTUC treated surgically from 1998 to 2013 were compiled. Patients with bilateral disease, less than 1 month follow up, missing hydronephrosis data, or who underwent nephron-sparing approaches were excluded...
August 2016: Canadian Journal of Urology
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