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https://www.readbyqxmd.com/read/29680209/6-formylindolo-3-2-b-carbazole-induced-aryl-hydrocarbon-receptor-activation-prevents-intestinal-barrier-dysfunction-through-regulation-of-claudin-2-expression
#1
Yuanhang Ma, Qimeng Wang, Kun Yu, Xin Fan, Weidong Xiao, Yujiao Cai, Pengyuan Xu, Min Yu, Hua Yang
6-formylindolo (3,2-b) carbazole (FICZ), a high-affinity aryl hydrocarbon receptor (AhR) ligand, plays a protective role in inflammatory bowel disease (IBD) through activation of AhR. Interleukin-6 (IL-6) induced intestinal epithelial barrier dysfunction is involved in the pathological process of IBD. In this study, we investigated the protective effects of FICZ on IL-6 induced intestinal epithelial barrier injury. Our data show that AhR activation by FICZ ameliorated colonic inflammation, decreased IL-6 and claudin-2 expression, and maintained intestinal barrier function in a mouse model of dextran sulphate sodium (DSS)-induced colitis...
April 19, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29658845/nivolumab-plus-ipilimumab-in-lung-cancer-with-a-high-tumor-mutational-burden
#2
Matthew D Hellmann, Tudor-Eliade Ciuleanu, Adam Pluzanski, Jong Seok Lee, Gregory A Otterson, Clarisse Audigier-Valette, Elisa Minenza, Helena Linardou, Sjaak Burgers, Pamela Salman, Hossein Borghaei, Suresh S Ramalingam, Julie Brahmer, Martin Reck, Kenneth J O'Byrne, William J Geese, George Green, Han Chang, Joseph Szustakowski, Prabhu Bhagavatheeswaran, Diane Healey, Yali Fu, Faith Nathan, Luis Paz-Ares
Background Nivolumab plus ipilimumab showed promising efficacy for the treatment of non-small-cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit. In this part of an open-label, multipart, phase 3 trial, we examined progression-free survival with nivolumab plus ipilimumab versus chemotherapy among patients with a high tumor mutational burden (≥10 mutations per megabase). Methods We enrolled patients with stage IV or recurrent NSCLC that was not previously treated with chemotherapy...
April 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29655798/a-potential-antibacterial-wound-dressing-of-cefadroxil-chitosan-nanoparticles-in-situ-gel-fabrication-in-vitro-optimization-and-in-vivo-evaluation
#3
Mona Basha, Mona M AbouSamra, Ghada A Awad, Soheir S Mansy
Wound healing following skin injury is a natural phenomenon that usually lacks quality, rapidity, and aesthetics. Thus, the purpose of this study was to fabricate a new easily applied in situ gel of Cefadroxil (CDX) loaded with chitosan nanoparticles (CDX-CSNPs) that could promote wound healing, capable of inhibiting the possible accompanying bacterial infection. The nanoparticles were prepared by double emulsion technique and the influence of formulation parameters on drug entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI) and zeta potential (ZP) were investigated using a full factorial design...
April 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29622581/targeting-tissue-factor-for-immunotherapy-of-triple-negative-breast-cancer-using-a-second-generation-icon
#4
Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth L McMichael, Lianbo Yu, Bhuvaneswari Ramaswamy, Cheryl A London, Tian Xu, William E Carson
Triple-negative breast cancer (TNBC) is a leading cause of breast cancer death and is often associated with BRCA1 and BRCA2 mutation. Due to the lack of validated target molecules, no targeted therapy for TNBC is approved. Tissue factor (TF) is a common yet specific surface target receptor for cancer cells, tumor vascular endothelial cells and cancer stem cells in several types of solid cancers including breast cancer. Here we report evidence supporting the idea that TF is a surface target in TNBC. We used in vitro cancer lines and in vivo tumor xenografts in mice, all with BRCA1 or BRCA2 mutations, derived from patients' tumors...
April 5, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29600239/clinical-outcome-study-of-crizotinib-in-immunohistochemistry-proven-echinoderm-microtubule-associated-protein-like-4-anaplastic-lymphoma-kinase-fusion-gene-among-indian-patients-with-adenocarcinoma-lung
#5
Ullas Batra, Mohit Aggarwal, Parveen Jain, Pankaj Goyal, Abhishek Yadav, Udip Maheshwari, Anurag Mehta
Aims: The anaplastic lymphoma kinase (ALK) Break Apart FISH Probe Kit and Ventana anti-ALK (D5F3) CDx immunohistochemistry (IHC) assay are the Food and Drug Administration-approved companion diagnostic for targeted therapy with the ALK inhibitor crizotinib in lung cancers. The aim of this study was to assess the efficacy and safety of twice daily crizotinib tablet (250 mg) in IHC-proven echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene among Indian patients with adenocarcinoma lung in the routine clinical practice...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29565568/comprehensively-understanding-isomorphism-and-photoluminescent-nature-of-two-dimensional-coordination-polymers-of-cd-ii-and-mn-ii-with-1-1-ethynebenzene-3-3-5-5-tetracarboxylic-ligand
#6
Lu Zhai, Zhu-Xi Yang, Wen-Wei Zhang, Jing-Lin Zuo, Xiao-Ming Ren
Four isomorphic two-dimensional (2D) homo- and heterometallic coordination polymers (CPs), [(Cdx Mn1- x )3 (HEBTC)2 (DMSO)6 ] with x = 1 (1), 1/3 (2), 0.5 (3), and 2/3 (4) were prepared by conventional one-pot self-assembly approach, using Cd2+ or mixtures of Cd2+ and Mn2+ with 1,1'-ethynebenzene-3,3',5,5'-tetracarboxylic (H4 EBTC) under solvothermal conditions. The crystal structures of four isomorphic CPs are composed of center-symmetric trinuclear metal clusters building units linked by HEBTC3- ligands, extending into (3, 6)-connected topological 2D nets...
March 22, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29540329/assessment-of-egfr-mutation-status-in-tunisian-patients-with-pulmonary-adenocarcinoma
#7
A Arfaoui Toumi, A Blel, R Aloui, H Zaibi, M Ksentinini, M S Boudaya, N Znaidi, Y Zidi, H Aouina, S Rammeh Rommani
BACKGROUND: Despite recent advances, non-small cell lung cancer carries a grim prognosis. For appropriate treatment selection, the updated guidelines recommend broad molecular profiling for all patients with pulmonary adenocarcinoma. Precise histological subtyping and targeted epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) testing are mandatory. METHODS: Herein, we assessed the EGFR mutation status of 26 formalin fixed-paraffin embedded (FFPE) samples of lung adenocarcinoma...
March 11, 2018: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29528343/high-efficiency-deep-blue-zncds-cd-x-zn-1-x-s-zns-quantum-dot-light-emitting-devices-with-an-eqe-exceeding-18
#8
Ouyang Wang, Lei Wang, Zhaohan Li, Qiulei Xu, Qingli Lin, Hongzhe Wang, Zuliang Du, Huaibin Shen, Lin Song Li
We report a facile and robust synthesis of ZnCdS core/shell quantum dots (QDs) with thick Cdx Zn1-x S (x = constant) uniform alloys as an intermediate shell which can provide effective confinement of excitons within the ZnCdS cores and ultrathin ZnS outermost shell to improve the stability by epitaxial growth at a relatively high temperature. The resulting nearly monodisperse ZnCdS/Cdx Zn1-x S/ZnS core/shell QDs have high photoluminescence quantum yield (near to 100%) and high color purity (full width at half maximum (FWHM) < 18 nm)...
March 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29494399/clinicopathologic-characteristics-of-thyroid-like-low-grade-nasopharyngeal-papillary-adenocarcinoma-a-case-report
#9
Liang Li, Fengjuan Zhou, Fanzhong Lin, Cuihong Han
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm. It morphologically resembles papillary thyroid carcinoma and is immunochemically positive for thyroid transcription factor 1. Herein, we reported a case of TL-LGNPPA in a female patient of 35 years old. She felt pharyngeal foreign body sensation of unknown cause and subsequently developed dyspnea after activities. Nasopharyngeal plain computerized tomography showed no abnormalities, but laryngoscopy showed a peanut-sized smooth neoplasm with a pedicel at the posterior edge of the nasal septum...
February 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29473324/establishment-and-characterization-of-in-vivo-orthotopic-bioluminescent-xenograft-models-from-human-osteosarcoma-cell-lines-in-swiss-nude-and-nsg-mice
#10
Maria Eugenia Marques da Costa, Estelle Daudigeos-Dubus, Anne Gomez-Brouchet, Olivia Bawa, Valerie Rouffiac, Massimo Serra, Katia Scotlandi, Conceição Santos, Birgit Geoerger, Nathalie Gaspar
Osteosarcoma is one of the most common primary bone tumors in childhood and adolescence. Metastases occurrence at diagnosis or during disease evolution is the main therapeutic challenge. New drug evaluation to improve patient survival requires the development of various preclinical models mimicking at best the complexity of the disease and its metastatic potential. We describe here the development and characteristics of two orthotopic bioluminescent (Luc/mKate2) cell-derived xenograft (CDX) models, Saos-2-B-Luc/mKate2-CDX and HOS-Luc/mKate2-CDX, in different immune (nude and NSG mouse strains) and bone (intratibial and paratibial with periosteum activation) contexts...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29456851/duodenal-mucinous-adenocarcinoma-presenting-as-ileus-obstructive-jaundice-and-massive-ascites-a-case-report
#11
Dongbing Ding, Yao Yao, Songbai Zhang
Duodenal mucinous adenocarcinoma (DMA) is a malignancy with a rather low morbidity. However, its incidence in China has not been clearly determined. We herein report a case of a 70-year-old female patient who presented with ileus, obstructive jaundice and massive ascites simultaneously. Gastroendoscopy revealed copious amounts of colloidal mucin in the gastric cavity. The neoplasm was not visualized on computed tomography or magnetic resonance imaging, and an exploratory laparotomy was performed to investigate the abdomen...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29449726/primary-well-differentiated-neuroendocrine-tumor-of-ovary-collides-with-mucinous-borderline-tumor-in-a-postmenopausal-female-a-report-of-case-and-review-of-literature
#12
M Shahid, A Siddiqi
Collision tumors represent a coexistence of two adjacent but histologically distinct tumors without histologic admixture in an organ. Primary well differentiated neuroendocrine tumor of ovary is rare and coexistent borderline mucinous tumor makes this association extremely rare. Although these tumors have been reported in other organs, its occurrence in ovary is rare. Collision tumor comprising primary neuroendocrine tumor of ovary and mucinous borderline tumor is an extremely rare occurrence. Here we report a case of this collision tumor in a postmenopausal female...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29442331/role-of-zic-family-proteins-in-transcriptional-regulation-and-chromatin-remodeling
#13
Minoru Hatayama, Jun Aruga
Proper functions of Zic proteins are essential for animals in health and disease. Here, we summarize our current understanding of the molecular properties and functions of the Zic family across animal species and paralog subtypes. Zics are basic proteins with some posttranslational modifications and can move to the cell nucleus via importin- and CRM1-based nucleocytoplasmic shuttling mechanisms. Degradation is mediated by the ubiquitin proteasome system. Many Zic proteins are capable of binding to two types of target DNA sequences (CTGCTG-core-type and GC-stretch-type)...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29440171/crosstalk-signaling-between-her3-and-hpv16-e6-and-e7-mediates-resistance-to-pi3k-inhibitors-in-head-and-neck-cancer
#14
Toni M Brand, Stefan Hartmann, Neil E Bhola, Hua Li, Yan Zang, Rachel A O'Keefe, Max V Ranall, Sourav Bandyopadhyay, Margaret Soucheray, Nevan J Krogan, Carolyn Kemp, Umamaheswar Duvvuri, Theresa LaVallee, Daniel E Johnson, Michelle A Ozbun, Julie E Bauman, Jennifer R Grandis
Human papillomavirus (HPV) type 16 is implicated in approximately 75% of head and neck squamous cell carcinomas (HNSCC) that arise in the oropharynx, where viral expression of the E6 and E7 oncoproteins promote cellular transformation, tumor growth, and maintenance. An important oncogenic signaling pathway activated by E6 and E7 is the phosphatidylinositol 3-kinase (PI3K) pathway, a key driver of carcinogenesis. The PI3K pathway is also activated by mutation or amplification of PIK3CA in over half of HPV(+) HNSCC...
February 12, 2018: Cancer Research
https://www.readbyqxmd.com/read/29433421/the-distribution-of-three-candidate-cold-resistant-snps-in-six-minorities-in-north-china
#15
Qiuyan Li, Kexian Dong, Lidan Xu, Xueyuan Jia, Jie Wu, Wenjing Sun, Xuelong Zhang, Songbin Fu
BACKGROUND: Heilongjiang Province located in northeast China is a multi-ethnic region with people who have lived in cold conditions for several generations. Fatty acids are important to people with cold resistance. CPT1A encodes a protein that imports long-chain fatty acids into the mitochondria for fatty-acid oxidation. FADS is an essential enzyme for the synthesis of long-chain polyunsaturated fatty acids. RESULTS: In the present study, we investigated the distributions of three cold resistance-related SNPs (rs80356779 G > A in CPT1A, rs7115739 T > G in FADS3 and rs174570 C > T in FADS2) from six populations that included 1093 individuals who have lived in Heilongjiang Province for at least three generations...
February 12, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29425647/predicting-tyrosinase-inhibition-by-3d-qsar-pharmacophore-models-and-designing-potential-tyrosinase-inhibitors-from-traditional-chinese-medicine-database
#16
Hongwei Gao
BACKGROUND: Tyrosinase plays a key role in the formation of skin melanin. The excessive accumulation of skin melanin will cause the serious aesthetic problems for human beings. HYPOTHESIS/PURPOSE: To find the potent tyrosinase inhibitors using computational simulation from TCM Database@Taiwan. STUDY DESIGN: Inhibitors of tyrosinase have been thought as potential drugs for the decrease of melanin synthesis in the process of pigmentation. To develop new tyrosinase inhibitors, we performed a virtual screening from Traditional Chinese medicine (TCM) and Druglike Databases using the best 3D QSAR pharmacophore model as a 3D search query...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29341470/cytological-features-of-mixed-adenoneuroendocrine-carcinoma-of-the-ampulla-of-vater-a-case-report-with-immunocytochemical-analyses
#17
Saya Yoshioka, Yusuke Ebisu, Mitsuaki Ishida, Yoshiko Uemura, Hiroaki Yanagimoto, Sohei Satoi, Koji Tsuta
Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor that has morphologically recognizable both adenocarcinoma and neuroendocrine carcinoma components comprising at least 30% of either components. MANEC occurring in the ampulla of Vater is extremely rare, and only 16 cases have been reported in the English language literature. In the present report, we describe the first case of MANEC of the ampulla of Vater with immunocytochemical analyses. An 82-year-old Japanese male was incidentally found to have a tumorous lesion in the ampulla of Vater...
January 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29339175/primary-thymic-adenocarcinomas-a-clinicopathological-and-immunohistochemical-study-of-16-cases-with-emphasis-on-the-morphological-spectrum-of-differentiation
#18
Neda Kalhor, Cesar A Moran
Sixteen cases of primary thymic adenocarcinoma are presented. The patients are 9 men and 7 women between the ages of 22 and 68 years (average: 45 years) who presented with non-specific symptoms including cough, chest pain, and dyspnea. Diagnostic imaging revealed the presence of an anterior mediastinal mass, which was surgically removed in all of the patients. Histologically, none of the tumors was encapsulated and showed different growth patterns including mucinous, non-mucinous, and papillary features. The majority of cases showed mixed growth pattern and the tumor was limited to the mediastinum with only a few cases extending to lymph nodes or pericardium...
January 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29243296/role-of-conventional-immunomarkers-hnf4-%C3%AE-and-satb2-in-the-differential-diagnosis-of-pulmonary-and-colorectal-adenocarcinomas
#19
Mark Kriegsmann, Alexander Harms, Rémi Longuespée, Thomas Muley, Hauke Winter, Katharina Kriegsmann, Daniel Kazdal, Benjamin Goeppert, Anita Pathil, Arne Warth
AIMS: Pulmonary (ADC) and colorectal (CRC) adenocarcinomas are frequent entities in pathological routine diagnostics. Whereas the differential diagnosis is usually straightforward based on histomorphology, it can be challenging in small biopsies. In general, CDX-2, CK20, Napsin-A and TTF-1 are recommended immunohistological markers in this scenario. Hepatocyte nuclear factor 4 alpha (HNF4-α) and special AT-rich sequence-binding protein 2 (SATB2) were described recently as promising additional markers, but comprehensive large-scale data are lacking so far...
December 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29202657/a-case-of-gastric-cancer-metastasis-to-the-breast-in-a-female-with-brca2-germline-mutation-and-literature-review
#20
Audrius Dulskas, Mahdi Al Bandar, Yoon Young Choi, Su-Jin Shin, Seung-Hoon Beom, Taeil Son, Hyung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
INTRODUCTION: Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly. PATIENTS AND METHODS: Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (BRCA2) germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast...
December 5, 2017: Acta Chirurgica Belgica
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