myathenia gravis

BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease caused by antibodies to acetylcholine receptors of the skeletal muscle. Myasthenic crisis (MC) is a complication observed during both early and late stage MG cases. In this study, we examined current treatments and three years outcomes in patients with MG and MC. We also investigated the impact of thymectomy and systemic lupus erythematosus (SLE) in patients with MG and MC. METHODS: In this retrospective study, we reviewed the medical records of all patients admitted to one teaching hospital between January 2006 and December 2014 and identified those for whom discharge diagnosis included the International Classification of Diseases, ninth revision (ICD-9) codes corresponding to MG (358...

From June 1983 to March 1992, 95 patients with of myasthenia gravis were treated with thyrmoma-thymectomy. Among them 90 patients were taken midsternotomy, and others standard lateral thoracotomy. All the patients had postoperative crisis of myathenia except one who had a cholinergic crisis. 12 patients (60%) belonged to type III and IV According to the Osserman's classification. The pathological findings showed that 17 patients had combined thyrmoma. The management for crisis was satisfactory with a success rate of 95%...

Two brothers with congenital myasthenia gravis are described. In both, ptosis and ophthalmoplegia responded poorly to oral anticholinesterase therapy and to thymectomy. The brothers had two different HLA haplotypes and neither had the HLA-A1-B8-DW3 haplotypes which are commonly associated with myathenia gravis in adult-onset cases.