keyword
MENU ▼
Read by QxMD icon Read
search

Drug and alcohol dependence

keyword
https://www.readbyqxmd.com/read/29339307/anticoccidial-activity-of-fruit-peel-of-punica-granatum-l
#1
Shazia Ahad, Syed Tanveer, Tauseef Ahmad Malik, Irshad Ahmad Nawchoo
In the interests of food safety and public health, plants and their compounds are now re-emerging as an alternative approach to treat parasitic diseases. Here, we studied the anticoccidial effect of different solvent extracts of the fruit peel of Punica granatum-a commercial waste from pomegranate juice industries. The hope underlying these experiments was to find a sustainable natural product for controlling coccidiosis. The plant extracts were prepared using solvents of different polarity. Acute oral toxicity study was first carried out to see the safety of crude extracts...
January 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29339294/ketamine-for-the-treatment-of-addiction-evidence-and-potential-mechanisms
#2
REVIEW
I Ivan Ezquerra-Romano, W Lawn, E Krupitsky, C J A Morgan
Ketamine is a dissociative anaesthetic drug which acts on the central nervous system chiefly through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Recently, ketamine has attracted attention as a rapid-acting anti-depressant but other studies have also reported its efficacy in reducing problematic alcohol and drug use. This review explores the preclinical and clinical research into ketamine's ability to treat addiction. Despite methodological limitations and the relative infancy of the field, results thus far are promising...
January 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29334513/opioid-use-disorders-attributed-to-tramadol-among-egyptian-university-students
#3
Medhat M Bassiony, Mohamed Abdelghani, Ghada M Salah El-Deen, Mervat S Hassan, Hayam El-Gohari, Usama M Youssef
BACKGROUND: Tramadol use is an overwhelming problem in Egypt with tremendous medical and social consequences especially among youth. Use liability among Egyptian university students is underevaluated. This study aimed to estimate the prevalence and associated correlates of tramadol use among students from Zagazig University, Egypt. METHODS: A cross-sectional study included a total of 1135 undergraduate students, from 10 colleges in Zagazig University. Participants were randomly selected and assessed for tramadol use using The Drug Use Disorders Identification Test (DUDIT) and The Drug Use Disorders Identification Test-Extended (DUDIT-E)...
January 12, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29330220/regulation-of-drug-metabolism-by-the-interplay-of-inflammatory-signaling-steatosis-and-xeno-sensing-receptors-in-heparg-cells
#4
Norman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M Zanger, Linda Bohmert, Alfonso Lampen, Albert Braeuning
Non-alcoholic fatty liver disease (NAFLD), characterized by triglyceride deposition in hepatocytes due to imbalanced lipid homeostasis, is of increasing concern in Western countries, with progression to non-alcoholic steatohepatitis (NASH), liver fibrosis, and cirrhosis. Previous studies suggest a complex, mutual influence of hepatic fat accumulation, NASH-related inflammatory mediators, and drug-sensing receptors regulating xenobiotic metabolism. Here, we investigated the suitability of human HepaRG hepatocarcinoma cells as a model for NAFLD and NASH...
January 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29327091/temporal-fluctuations-in-behavior-perceived-hiv-risk-and-willingness-to-use-pre-exposure-prophylaxis-prep
#5
Kristen Underhill, Kate M Guthrie, Christopher Colleran, Sarah K Calabrese, Don Operario, Kenneth H Mayer
Individual perceptions of HIV risk influence willingness to use pre-exposure prophylaxis (PrEP) for HIV prevention. Among men who have sex with men (MSM) and male sex workers (MSWs), temporal or episodic changes in risk behavior may influence perceived risk and PrEP acceptability over time. We investigated fluctuations in perceived HIV risk and PrEP acceptability, comparing MSWs against MSM who do not engage in sex work. We conducted 8 focus groups (n = 38) and 56 individual interviews among MSM and MSWs in Providence, RI...
January 11, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29322265/the-role-of-sphingolipids-in-psychoactive-drug-use-and-addiction
#6
REVIEW
Liubov S Kalinichenko, Erich Gulbins, Johannes Kornhuber, Christian P Müller
Psychoactive drug use is a common behavior in many societies worldwide, frequently associated with drug instrumentalization. Regular use may develop into drug addiction, which is a severe psychiatric disorder with multiple pathological effects to virtually all organ systems. Treatment strategies for addiction are often insufficient with no broadly working pharmaco-treatment available. Recently, lipids, and particularly sphingolipids, have been considered as new mediators in the pathogenic pathways and as possible therapeutic targets for the treatment of addictive states...
January 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29317484/chemogenetic-excitation-of-accumbens-projecting-infralimbic-cortical-neurons-blocks-toluene-induced-conditioned-place-preference
#7
Wesley N Wayman, John J Woodward
Abuse rates for inhalants among adolescents continue to be high, yet preclinical models for studying mechanisms underlying inhalant abuse remain limited. Our lab has previously shown that, in male rats, an acute binge-like exposure to toluene vapor that mimics human solvent abuse modifies the intrinsic excitability of medial prefrontal cortex (mPFC) pyramidal neurons projecting to the nucleus accumbens (NAc). These changes showed region (infralimbic; IL vs. prelimbic; PRL), layer (shallow; 2/3 vs. deep; 5/6), target (core vs...
January 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29314309/how-do-people-with-homelessness-and-alcohol-dependence-cope-when-alcohol-is-unaffordable-a-comparison-of-residents-of-canadian-managed-alcohol-programs-and-locally-recruited-controls
#8
Rebekah A Erickson, Tim Stockwell, Bernadette Pauly, Clifton Chow, Audra Roemer, Jinhui Zhao, Kate Vallance, Ashley Wettlaufer
INTRODUCTION AND AIMS: We investigated coping strategies used by alcohol-dependent and unstably housed people when they could not afford alcohol, and how managed alcohol program (MAP) participation influenced these. The aim of this study was to investigate potential negative unintended consequences of alcohol being unaffordable. DESIGN AND METHODS: A total of 175 MAP residents in five Canadian cities and 189 control participants from nearby shelters were interviewed about the frequency they used 10 coping strategies when unable to afford alcohol...
January 4, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29313245/effect-of-post-traumatic-stress-disorder-on-cognitive-function-and-covert-hepatic-encephalopathy-diagnosis-in-cirrhotic-veterans
#9
Thomas K Burroughs, James B Wade, Michael S Ellwood, Andrew Fagan, Douglas M Heuman, Michael Fuchs, Jasmohan S Bajaj
BACKGROUND: In veterans, post-traumatic stress disorder (PTSD) is often associated with substance abuse, which in turn can lead to cirrhosis. Cirrhotic patients are prone to cognitive impairment, which is typically due to covert hepatic encephalopathy (CHE), but can also be affected by PTSD. The aim was to define the impact of PTSD on cognitive performance and the diagnosis of CHE in cirrhotic patients. METHODS: Outpatient veterans with cirrhosis underwent two separate modalities for CHE cognitive testing [Psychometric Hepatic Encephalopathy Scale (PHES) and Inhibitory Control Test (ICT)]...
January 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29313106/neural-correlates-of-instrumental-responding-in-the-context-of-alcohol-related-cues-index-disorder-severity-and-relapse-risk
#10
Daniel J Schad, Maria Garbusow, Eva Friedel, Christian Sommer, Miriam Sebold, Claudia Hägele, Nadine Bernhardt, Stephan Nebe, Sören Kuitunen-Paul, Shuyan Liu, Uta Eichmann, Anne Beck, Hans-Ulrich Wittchen, Henrik Walter, Philipp Sterzer, Ulrich S Zimmermann, Michael N Smolka, Florian Schlagenhauf, Quentin J M Huys, Andreas Heinz, Michael A Rapp
The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives...
January 8, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29306817/effect-of-electronic-brief-intervention-on-uptake-of-specialty-treatment-in-hospital-outpatients-with-likely-alcohol-dependence-pilot-randomized-trial-and-qualitative-interviews
#11
Natalie A Johnson, Kypros Kypri, Joanna Latter, Adrian Dunlop, Amanda Brown, Richard Saitz, John B Saunders, John Attia, Luke Wolfenden, Christopher Doran, Jim McCambridge
BACKGROUND: A large proportion of hospital outpatients are alcohol dependent (AD) but few are engaged in treatment for their drinking. Brief intervention, designed to raise patients' awareness of their drinking, might encourage uptake of referral to specialty treatment. We assessed the feasibility of conducting a randomized trial evaluating the effectiveness of electronic brief intervention on the uptake of specialty treatment in hospital outpatients with likely AD. METHODS: This study was conducted in the outpatient department of a large public hospital in Newcastle, Australia...
January 2, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29306172/corrigendum-to-subjective-experiences-at-first-use-of-cigarette-e-cigarettes-hookah-and-cigar-products-among-texas-adolescents-drug-alcohol-depend-173-1-2017-10-16
#12
Dale S Mantey, Melissa B Harrell, Kathleen Case, Brittani Crook, Steven H Kelder, Cheryl L Perry
No abstract text is available yet for this article.
January 3, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29299208/the-relationship-between-personality-disorders-and-the-type-of-crime-committed-and-substance-used-among-prisoners
#13
Shahin Fakhrzadegan, Hossein Gholami-Doon, Bagher Shamloo, Solmaz Shokouhi-Moqhaddam
Background: Prisoners are a vulnerable group within societies, and also threaten society due to their dangerous behavior. The objective of the present study was to evaluate the relationship between prisoners' personality disorders and their crime and substance use. Methods: This was a descriptive-correlational study. The statistical population consisted of all prisoners of Kerman, Iran. Through stratified random sampling, 228 prisoners (114 women and 114 men) were selected as the study subjects...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29298737/a-feasible-model-for-early-intervention-for-high-risk-substance-use-in-the-emergency-department-setting
#14
Rebecca Howard, Stephanie Fry, Andrew Chan, Brigid Ryan, Yvonne Bonomo
Objective In response to escalating alcohol and other drug (AOD)-related emergency department (ED) presentations, a tertiary Melbourne hospital embedded experienced AOD clinical nurse consultants in the ED on weekends to trial a model for screening, assessment and brief intervention (BI). The aim of the present study was to evaluate the relative contributions of AOD to ED presentations and to pilot a BI model.Methods Using a customised AOD screening tool and a framework for proactive case finding, screened participants were offered a comprehensive AOD assessment and BI in the ED...
January 4, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29297862/estimate-of-the-prevalence-of-subjects-with-gambling-related-problems-requiring-treatment-a-study-in-northern-italy
#15
Raimondo Maria Pavarin, Corrado Zenesini, Angelo Fioritti
This study analyzes the data related to subjects who for the first time turned to a hospital or to a Public Treatment Service Dedicated to Drug Addicts or to a Community Mental Health Center for problems related to pathological gambling in the metropolitan area of Bologna (Northern Italy) in the period 2000/2015. The aims were to describe characteristics and problems of pathological gamblers (PGs), and to estimate the prevalence of PGs using the capture-recapture method. Four hundred and ninety-five residents were identified, with an estimate of 1570 PGs and a prevalence of 1...
October 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29291393/patchouli-alcohol-protects-against-ischemia-reperfusion-induced-brain-injury-via-inhibiting-neuroinflammation-in-normal-and-obese-mice
#16
Li-Li Wei, Yong Chen, Qiong-Yang Yu, Yuhui Wang, George Liu
Almost all of the candidate drugs for ischemic stroke failed to be translated from bench to beside. One important reason is that animals used in experimental studies cannot mimic ischemic patients due to lack of comorbidities like hypertension, diabetes and obesity. Therefore, it is better to test candidate drugs not only in normal animals but also in animals with comorbidities. Patchouli alcohol (PA), a natural tricyclic sesquiterpene in the traditional Chinese herb Pogostemonisherba, is well recognized for its anti-inflammation function in various inflammatory diseases...
December 29, 2017: Brain Research
https://www.readbyqxmd.com/read/29286538/effect-of-gabapentin-on-sleep-and-event-related-oscillations-eros-in-rats-exposed-to-chronic-intermittent-ethanol-vapor-and-protracted-withdrawal
#17
Manuel Sanchez-Alavez, Derek N Wills, Leslie Amodeo, Cindy L Ehlers
Disturbances in sleep architecture, especially reductions in slow wave sleep (SWS), are symptoms commonly observed in individuals with alcohol use disorders (AUDs). Recent clinical trials have demonstrated that the anticonvulsant and analgesic drug Gabapentin may have therapeutic value in normalizing sleep quality in recovering alcoholics. However, the brain mechanisms underlying this improvement in sleep following Gabapentin treatment remain unknown METHODS: In the present study, adult Wistar rats were exposed to 8 weeks of chronic intermittent ethanol vapor (CIE) (blood ethanol concentrations averaged 128...
December 29, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29274237/lipase-catalyzed-kinetic-resolution-of-novel-antitubercular-benzoxazole-derivatives
#18
Edyta Łukowska-Chojnacka, Anna Kowalkowska, Agnieszka Napiórkowska
Novel benzoxazole derivatives were synthesized, and their antitubercular activity against sensitive and drug-resistant Mycobacterium tuberculosis strains (M. tuberculosis H37 Rv, M. tuberculosis sp. 210, M. tuberculosis sp. 192, Mycobacterium scrofulaceum, Mycobacterium intracellulare, Mycobacterium fortuitum, Mycobacterium avium, and Mycobacterium kansasii) was evaluated. The chemical step included preparation of ketones, alcohols, and esters bearing benzoxazole moiety. All racemic mixtures of alcohols and esters were separated in Novozyme SP 435-catalyzed transesterification and hydrolysis, respectively...
December 23, 2017: Chirality
https://www.readbyqxmd.com/read/29272996/spontaneous-first-trimester-miscarriage-rates-per-woman-among-parous-women-with-1-or-more-pregnancies-of-24-weeks-or-more
#19
Judy Slome Cohain, Rina E Buxbaum, David Mankuta
BACKGROUND: The purpose of this study was to quantify spontaneous first trimester miscarriage rates per woman among parous women. A vast amount of data has accumulated regarding miscarriage rates per recognized pregnancy as well as about recurrent miscarriage. This is the second study of miscarriage rates per woman in a parous population and the first study of recurrent and non-recurrent, spontaneous first trimester miscarriage rates per woman in a large parous population. METHODS: Extraction of the following variables from all delivery room admissions from both Hadassah Medical Centers in Jerusalem Israel, 2004-2014: # of first trimester spontaneous miscarriages, # live births; # living children; age on admission, pre-pregnancy height and weight, any smoking this pregnancy, any alcohol or drug abuse this pregnancy, blood type, history of ectopic pregnancy, history of cesarean surgery (CS) and use of any fertility treatment(s)...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29261453/impairment-of-functioning-and-substance-use-in-a-latino-population
#20
Alfonso Mercado, Liza Talavera Garza, Jason Popan, Kim Finn-Nguyen, Rachita Sharma, Cecilia Colunga-Rodriguez
This study investigated the association of academic outcomes, romantic relationships, and substance use (tobacco, marijuana, cocaine) with alcohol dependence in a sample of Latino (N = 1,143) college students. Secondary data analysis was conducted on measures of grade point average in college, relationship satisfaction, drug use, and alcohol dependence. Latino college students who reported alcohol dependency had significant relational dissatisfaction and poor academic outcomes. Thus, lower grade point average and relationship dissatisfaction were associated with alcohol dependence...
December 20, 2017: Journal of Ethnicity in Substance Abuse
keyword
keyword
47139
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"