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https://www.readbyqxmd.com/read/28099093/patients-with-infectious-endocarditis-and-drug-dependence-have-worse-clinical-outcomes-after-valvular-surgery
#1
Anthony Lemaire, Viktor Dombrovskiy, Siavash Saadat, George Batsides, Aziz Ghaly, Alan Spotnitz, Leonard Y Lee
BACKGROUND: Patients with infective endocarditis (IE) are at high risk for post-operative morbidity and death, which might be associated with drug abuse. The purpose of this study is to evaluate the impact of drug dependence on outcomes in patients who have IE and undergo valvular surgery (VS). PATIENTS AND METHODS: The Nationwide/National Inpatient Sample 2001-2012 was queried to select patients with IE who had elective VS using International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis and procedure codes...
January 18, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28097536/prevalence-and-correlates-of-adhd-in-individuals-with-substance-use-disorder-in-nigeria
#2
Musa U Umar, Auwal S Salihu, Shakirat D Owolabi
Substance use disorder (SUD) is associated with ADHD. ADHD increases the severity of SUD and has negative influence on the prognosis of the disorder. The aim of the study was to determine the prevalence and correlates of ADHD in individuals with SUD. During 2013-2015, a cross-sectional descriptive study of 233 drug treatment-seeking individuals was assessed. Diagnosis of ADHD was done using DSM-IV criteria with the Diagnostic Interview for ADHD in Adults (DIVA 2.0), while Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA 6...
January 17, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28092494/zebrafish-are-able-to-detect-ethanol-in-their-environment
#3
Steven Tran, Hayden Chow, Benjamin Tsang, Amanda Facciol, Prabhlene Gandhi, Priyanka Desai, Robert Gerlai
Zebrafish have become a popular animal model for studying the development of alcohol addiction. Several behavioral paradigms for studying alcohol addiction have been developed for zebrafish, including conditioned place preference, alcohol-induced tolerance, and withdrawal. However, alcohol choice preference tasks have not been established in zebrafish as of yet. The ability of zebrafish to detect alcohol in their environment is required in alcohol choice or preference tasks. To our knowledge, it is currently unknown whether zebrafish are able to detect alcohol in their environment immediately following bath immersion...
January 16, 2017: Zebrafish
https://www.readbyqxmd.com/read/28088742/patterns-of-drug-use-and-hiv-infection-among-adults-in-a-nationally-representative-sample
#4
Stephanie Shiau, Stephen M Arpadi, Michael T Yin, Silvia S Martins
BACKGROUND: Little is known about drug use patterns among people living with HIV in comparison to an uninfected group in the general population. The aim of this study was to investigate the association between legal and illegal drug use and HIV infection in a nationally representative sample of adults in the United States. METHODS: Public use data files (2005-2014) from the National Survey on Drug Use and Health (NSDUH) were used. Respondents were asked whether a medical professional had ever told them that they had HIV/AIDS...
January 7, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28088388/activation-of-gr-but-not-pxr-by-dexamethasone-attenuated-acetaminophen-hepatotoxicities-via-fgf21-induction
#5
Saurabh G Vispute, Pengli Bu, Yuan Le, Xingguo Cheng
Glucocorticoid receptor (GR) signaling is indispensable for cell growth and development, and plays important roles in drug metabolism. Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols. The present study investigates the impact of dexamethasone (DEX)-activated GR on Fgf21 expression and how it affects the progression of APAP-induced hepatotoxicity...
January 11, 2017: Toxicology
https://www.readbyqxmd.com/read/28087970/liquid-chromatography-mass-spectrometry-high-resolution-for-the-determination-of-baclofen-and-its-metabolites-in-plasma-application-to-therapeutic-drug-monitoring
#6
Laurence Labat, Antonio Goncalves, Ana Rita Marques, Bénédicte Duretz, Bernard Granger, Xavier Declèves
Baclofen is actually used to manage alcohol dependence. This study describes a simple method using liquid chromatography coupled to high resolution mass spectrometry (LC-HR-MS) developed in plasma samples. This method was optimized to allow quantification of baclofen and determination of metabolic ratio of its metabolites, an oxidative deaminated metabolite of baclofen (M1) and its glucuronide form (M2). The LC-HR-MS method on Exactive® apparatus is a new developed method with all the advantages of the high resolution in full scan mode for the quantification of baclofen and detection of its metabolites in plasma...
January 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28081178/gender-differences-in-hiv-care-among-criminal-justice-involved-persons-baseline-data-from-the-care-corrections-study
#7
Curt Beckwith, Breana Uhrig Castonguay, Claudia Trezza, Lauri Bazerman, Rudy Patrick, Alice Cates, Halli Olsen, Ann Kurth, Tao Liu, James Peterson, Irene Kuo
BACKGROUND: HIV-infected individuals recently released from incarceration have suboptimal linkage and engagement in community HIV care. We conducted a study to evaluate an information and communication technology intervention to increase linkage to community care among HIV-infected persons recently involved in the criminal justice (CJ) system. Baseline characteristics including risk behaviors and HIV care indicators are reported and stratified by gender. METHODS: We recruited HIV-infected individuals in the District of Columbia jail and persons with a recent history of incarceration through community and street outreach...
2017: PloS One
https://www.readbyqxmd.com/read/28077940/physician-tobacco-screening-and-advice-to-quit-among-u-s-adolescents-national-survey-on-drug-use-and-health-2013
#8
Lauren Collins, Sabrina L Smiley, Rakiya A Moore, Amanda L Graham, Andrea C Villanti
BACKGROUND: Initiating tobacco use in adolescence increases the risk of nicotine dependence and continued smoking. Physician screening for tobacco use increases the odds of physicians intervening with patients who smoke; However, without appropriate follow-through by the physician, screening for tobacco use is not enough to significantly increase cessation rates. Given the critical phase of development adolescence poses in tobacco use and evidence that physician intervention improves adult cessation efforts, we sought to examine physician tobacco use screening and advice to quit among adolescents (12-17 years)...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28076644/main-mental-disorders-in-crack-cocaine-users-treated-at-psychosocial-care-centers-for-alcohol-and-drugs-in-the-city-of-recife-brazil
#9
Antonio Gomes de Castro, Diego César Nunes da Silva, Magda da Silva Figueiroa
Introduction: Brazil's Northeast region has the highest crack-cocaine consumption in the country. Crack-cocaine has more intense effects than cocaine powder and can cause greater chemical dependence. Psychosocial Care Centers for Alcohol and Drugs (CAPSad) are public health services that provide treatment for drug dependence. It is common for drug users, and particularly crack-cocaine users, to develop mental disorders. Objective: To evaluate the most common mental disorders in crack-cocaine dependents in treatment at CAPSad in the city of Recife, Brazil...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28074568/the-relative-impact-of-brief-treatment-versus-brief-intervention-in-primary-health-care-screening-programs-for-substance-use-disorders
#10
Arnie Aldridge, William Dowd, Jeremy Bray
AIMS: To assess the relative impact of brief treatment (BT) compared with brief intervention (BI) on changes in substance use behavior in primary care screening programs for substance use disorders, overall and by patient severity. DESIGN AND PARTICIPANTS: A total of 9029 patients with both baseline and follow-up interviews were identified in the US Government Performance and Results Act (GPRA) data from October 2004 and February 2008. Using a propensity score framework, multiple generalized linear mixed models and a local linear matching method with a difference in difference estimator, patients from the BI group that resemble BT patients were used to determine the relative treatment effect of BT...
February 2017: Addiction
https://www.readbyqxmd.com/read/28059434/assessment-of-abuse-liability-of-tramadol-among-experienced-drug-users-double-blind-crossover-randomized-controlled-trial
#11
Mrinmay Das, Raka Jain, Anju Dhawan, Amandeep Kaur
BACKGROUND: Tramadol is a widely used opioid analgesic. Different preclinical, clinical, and postmarketing surveillance studies show conflicting results regarding abuse potential of this drug. METHODS: A randomized double-blind complete crossover study was conducted at National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi. Total subjects were 10, comprising total 120 observations (each subject assessed at baseline, 5, 45, and 240 minutes)...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/28057079/prevalence-and-factors-associated-with-use-of-khat-a-survey-of-patients-entering-hiv-treatment-programs-in-ethiopia
#12
Alan R Lifson, Sale Workneh, Tibebe Shenie, Desalegn Admassu Ayana, Zenebe Melaku, Lemlem Bezabih, Hiwot Tekle Waktola, Behailu Dagne, Rose Hilk, Ken C Winters, Lucy Slater
BACKGROUND: Khat, a plant native to East Africa, has psychoactive constituents similar to amphetamine. Chronic khat use can lead to psychological dependence with multiple physical and mental health harms, complicating clinical management of people living with HIV. In two Ethiopian cities where khat is common, we evaluated prevalence and correlates of khat use among patients new to HIV care. METHODS: During 2013-2014, we surveyed 322 patients recently enrolled in HIV clinics in Dire Dawa and Harar about khat use, demographics, smoking and alcohol use, clinical illness, food insecurity, and social support...
January 6, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28054975/determinants-of-quality-of-life-in-high-dose-benzodiazepine-misusers
#13
Stefano Tamburin, Angela Federico, Marco Faccini, Rebecca Casari, Laura Morbioli, Valentina Sartore, Antonio Mirijello, Giovanni Addolorato, Fabio Lugoboni
Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries, but they have a high potential for tolerance, dependence and misuse. High-dose BZD misuse represents an emerging addiction phenomenon, but data on quality of life (QoL) in high-dose BZD misusers are scant. This study aimed to explore QoL in high-dose BZD misuse. We recruited 267 high-dose BZD misusers, compared the QoL scores in those who took BZD only to poly-drug misusers, and explored the role of demographic and clinical covariates through multivariable analysis...
January 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28052001/genetic-polymorphisms-in-aldh2-are-associated-with-drug-addiction-in-a-chinese-han-population
#14
Chan Zhang, Heng Ding, Yujing Cheng, Wanlu Chen, Qi Li, Qing Li, Run Dai, Manlin Luo
We investigated the association between single nucleotide polymorphisms (SNPs) in ALDH2, which has been associated with alcohol dependence and several types of diseases, and the risk of drug addiction in a Chinese Han population. In a case-control study that included 692 cases and 700 healthy controls, eight SNPs in ALDH2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28051830/gambling-and-the-need-for-new-responses-in-public-health-with-an-addiction-sine-substantia
#15
M Crusco, F Massoni, E Luzi, P Ricci, M Pelosi, P Corbosiero, M Rapp-Ricciardi, S Ricci
BACKGROUND: The Gambling Disorder (GD) was recently defined as a behavioral addiction by the "The Diagnostic and Statistical Manual of Mental Disorders IV"( DSM-V) since the clinical, neurobiological and psychopathological similarities led it to be defined it as an addiction "sine substantia". The aim of this study is to formulate an "identikit" of the gambler, to evaluate a possible association between GD / emotional specific factors and the correlation between GD / substance abuse, GD / suicide...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28042871/acute-d3-antagonist-gsk598809-selectively-enhances-neural-response-during-monetary-reward-anticipation-in-drug-and-alcohol-dependence
#16
Anna Murphy, Liam J Nestor, John McGonigle, Louise Paterson, Venkataramana Boyapati, Karen D Ersche, Remy Flechais, Shankar Kuchibatla, Antonio Metastasio, Csaba Orban, Filippo Passetti, Laurence Reed, Dana Smith, John Suckling, Eleanor Taylor, Trevor W Robbins, Anne Lingford-Hughes, David J Nutt, John Fw Deakin, Rebecca Elliott
: Evidence suggests that disturbances in neurobiological mechanisms of reward and inhibitory control maintain addiction and provoke relapse during abstinence. Abnormalities within the dopamine system may contribute to these disturbances and pharmacologically targeting the D3 dopamine receptor (DRD3) is therefore of significant clinical interest. We used functional magnetic resonance imaging to investigate the acute effects of the DRD3 antagonist GSK598809 on anticipatory reward processing, using the monetary incentive delay task (MIDT), and response inhibition using the go/no-go task (GNGT)...
January 2, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28041659/-predictive-factors-of-lost-to-follow-up-status-during-tuberculosis-treatment-in-brazzaville
#17
E L P Bemba, R G Bopaka, R Ossibi-Ibara, S N Toungou, B K Ossale-Abacka, F H Okemba-Okombi, J Mboussa
INTRODUCTION: The abandonment of TB treatment has consequences both individual by increasing the risk of drug resistance and collective seeding entourage. The aim of this study is to determine the risk factors to be lost sight of during TB treatment. PATIENTS AND METHODS: He acted in a prospective cohort study of patients with microbiologically confirmed tuberculosis, beginning TB treatment and followed for six months. The comparative study between 75 patients lost (PL) and 108 no-patients lost (NPL)...
December 29, 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28035127/medical-use-nonmedical-use-of-prescription-medication-and-risk-behaviour-among-croatian-adolescents
#18
Marina Kuzman, Marija Posavec
BACKGROUND: At the drug scene some major shifts were observed, more and more reports highlighted the abuse of prescription medication. Despite the importance of controlled medication in treatment child and adolescent disorders, this increase may be a factor which influence misuse and nonmedical use of prescribed drugs among adolescents. SUBJECT AND METHODS: Croatian data from ESPAD survey in 2003, 2007 and 2011 were used, and variables selected from the international ESPAD questionnaire...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/28032255/treatment-recommendations-for-schizophrenia-major-depression-and-alcohol-dependence-and-stigmatizing-attitudes-of-the-public-results-from-a-german-population-survey
#19
Sven Speerforck, Georg Schomerus, Herbert Matschinger, Matthias C Angermeyer
In addition to mental health literacy, several potentially conflicting emotions and attitudes among the public are hypothesized to guide their recommendations for specific mental health treatments. It is unclear whether evidence-based treatment strategies are guided by pro-social or stigmatizing attitudes and emotions. In a representative population survey in Germany (n = 3642), we asked respondents to what extent they would recommend psychotropic medication, psychotherapy and relaxation techniques for a person with mental illness described in an unlabelled vignette...
December 28, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28030933/event-related-potentials-erp-and-sgip1-gene-polymorphisms-in-alcoholics-relation-to-family-history-of-alcoholism-and-drug-usage
#20
Roman Chwedorowicz, Grzegorz Raszewski, Lucyna Kapka-Skrzypczak, Krzysztof Sawicki, Tadeusz Studziński
OBJECTIVE: The electrophysiological characteristics may serve as valuable biomarkers for the genetic vulnerability underlying alcoholism. The purpose of this study was to evaluate the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and the theta ERP quantitative traits. METHOD: The theta band (4-7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in five regions: frontal, central, parietal, temporal and occipital in patients with alcohol addiction...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
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