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Drug and alcohol dependence

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https://www.readbyqxmd.com/read/28727662/paraphilic-thoughts-behaviors-and-sex-addiction-in-a-sample-of-persons-who-use-drugs-a-cross-sectional-study
#1
Jales Clemente, Sandra Cristina Pillon, Jair de Jesus Mari, Claudio Jeronimo da Silva, Paulo Roberto Henrique Santana, Alessandra Diehl
OBJECTIVE: The aim of this study was to evaluate the prevalence of paraphilic thoughts/behaviors (including paraphilic disorders) with and without sexual addiction and sexual-related conditions in a sample of substance disorder patients. METHODS: This was a cross-sectional study of substance-dependent individuals who sought outpatient treatment in São Paulo, Brazil. Data included sociodemographic information, drug of choice, responses to questions about sexual behavior, and to the following standardized questionnaires: (a) Sexual Addiction Screening Test, and (b) Childhood Trauma Questionnaire...
July 19, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28724038/sexual-addiction-in-drug-addicts-the-impact-of-drug-of-choice-and-poly-addiction
#2
Nelson Antonio, Alessandra Diehl, Marcelo Niel, Sandra Pillon, Lilian Ratto, Maria Carolina Pinheiro, Dartiu Silveira, Thais Zelia Otani, Victor Otani, Quirino Cordeiro, Ricardo Ushida
Objective: To compare the risk of comorbid sexual addiction in a sample of individuals with a diagnosis of substance dependence, stratifying the sample by drug of choice as well as by mono versus polysubstance addiction. Method: All data were collected at Santa Casa de São Paulo, Brazil. The study sample comprised all alcohol or drug dependents admitted to the Addiction Treatment Unit between November 2013 and August 2014. A generalized linear model with a binomial distribution was performed to compare the odds of having a Sexual Addiction Screening Test (SAST) score greater than 6 points in the subgroups analyzed...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28723266/age-of-initiation-psychopathology-and-other-substance-use-are-associated-with-time-to-use-disorder-diagnosis-in-persons-using-opioids-nonmedically
#3
Ty S Schepis, Jahn K Hakes
BACKGROUND: Nonmedical use of prescription opioids (NMUPO) is an ongoing public health challenge, as NMUPO is associated with psychopathology, other drug use and fatal overdose. These concomitant risks are greatest in those with opioid use disorder (OUD), but the development of NMUPO-related use disorder is poorly understood. The primary aim of this study was to establish factors associated with the development of and time to OUD among persons engaged in NMUPO. METHODS: Data were from Wave 1 of the National Epidemiologic Study on Alcohol and Related Conditions, with 1,755 participants endorsing lifetime NMUPO...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28719029/directly-observed-therapy-of-sofosbuvir-ribavirin-peginterferon-with-minimal-monitoring-for-the-treatment-of-chronic-hepatitis-c-in-people-with-a-history-of-drug-use-in-chennai-india-c-dot
#4
Sunil S Solomon, Mark S Sulkowski, Pradeep Amrose, Aylur K Srikrishnan, Allison M McFall, Balakrishnan Ramasamy, Muniratnam S Kumar, Santhanam Anand, David L Thomas, Shruti H Mehta
BACKGROUND AND AIMS: We assessed the feasibility of field-based directly observed therapy (DOT) with minimal monitoring to deliver HCV treatment to people with a history of drug use in Chennai, India. METHODS: 50 participants were randomized 1:1 to sofosbuvir + peginterferon alfa 2a + ribavirin (SOF+PR) for 12 weeks (Arm 1) vs. sofosbuvir + ribavirin (SOF+R) for 24 weeks (Arm 2). SOF+R was delivered daily at participant chosen venues and weekly peginterferon injections at the study clinic...
July 18, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28716791/factors-associated-with-nicotine-dependence-during-methadone-maintenance-treatment-findings-from-a-multisite-survey-in-vietnam
#5
Huyen Phuc Do, Long Hoang Nguyen, Nhung Phuong Thi Nguyen, Chau Ngo, Huong Lan Thi Nguyen, Giang Tong Le, Linh Khanh Nguyen, Cuong Tat Nguyen, Bach Xuan Tran, Huong Thi Le, Thuc Minh Thi Vu, Huong Thu Thi Phan, Tho Dinh Tran, Carl A Latkin, Michael P Dunne
OBJECTIVES: Smoking is associated with adverse health outcomes among drug users, including those in treatment. To date, however, there has been little evidence about smoking patterns among people receiving opioid-dependence treatment in developing countries. We examined self-reported nicotine dependence and associated factors in a large sample of opioid-dependent patients receiving methadone maintenance treatment (MMT) in northern Vietnam. SETTING: Five clinics in Hanoi (urban area) and Nam Dinh (rural area)...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28715699/gambling-and-negative-life-events-in-a-nationally-representative-sample-of-uk-men
#6
Amanda Roberts, Stephen Sharman, Jeremy Coid, Raegan Murphy, Henrietta Bowden-Jones, Sean Cowlishaw, Jason Landon
INTRODUCTION: The links between gambling problems, trauma and life stressors are known to exist but understanding the extent of these relationships will allow for greater efficacy in early intervention and treatment. We investigated these relationships among men and sought to determine whether links were attenuated by alcohol and drug use problems. METHODS: A cross-sectional UK representative general population survey was conducted in 2009 with 3025 men aged 18-64years...
July 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28711193/nociceptin-receptors-in-alcohol-use-disorders-a%C3%A2-positron-emission-tomography-study-using-11-c-nop-1a
#7
Rajesh Narendran, Roberto Ciccocioppo, Brian Lopresti, Jennifer Paris, Michael L Himes, N Scott Mason
BACKGROUND: The neuropeptide transmitter nociceptin, which binds to the nociceptin/orphanin FQ peptide (NOP) receptor, is a core component of the brain's antistress system. Nociceptin exerts its antistress effect by counteracting the functions of corticotropin-releasing factor, the primary stress-mediating neuropeptide in the brain. Basic investigations support a role for medications that target nociceptin receptors in the treatment of alcohol use disorders. Thus, it is of high interest to measure the in vivo status of NOP receptors in individuals with alcohol use disorders...
May 31, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28704766/differential-effects-of-perceived-stress-on-alcohol-consumption-in-moderate-versus-heavy-drinking-hiv-infected-women
#8
Heidi Hutton, Catherine R Lesko, Geetanjali Chander, Bryan Lau, Gary S Wand, Mary E McCaul
OBJECTIVE: To examine the association between perceived stress and subsequent alcohol use in women living with HIV. METHODS: Women (n=338) receiving HIV care between April 2006 and July 2010 who enrolled in either a brief intervention for hazardous drinking or a cohort of non-hazardous drinkers completed a 90-day drinking and drug use history, and completed stress, depression and anxiety measures at 0, 6, and 12 months. We examined the association between perceived stress at months 0 or 6 and measures of quantity and frequency of alcohol use in months 3-6 and 9-12, respectively...
June 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28702262/hemispheric-asymmetry-of-development-due-to-drug-exposure
#9
Harold W Gordon
BACKGROUND: A previous survey of the literature of fMRI brain activation for two risk factors, impulsivity and craving, for addiction were lateralized to the right and left hemispheres respectively. Most articles reported these findings without consideration of how lateral asymmetries might be relevant to understanding the underlying factors leading to addiction. OBJECTIVE: The current survey is intended to extend these observations by demonstrating hemispheric asymmetry of development due to pre-natal or adolescent/adult exposure to drugs of abuse...
2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28701746/acute-d3-antagonist-gsk598809-selectively-enhances-neural-response-during-monetary-reward-anticipation-in-drug-and-alcohol-dependence
#10
Anna Murphy, Liam J Nestor, John McGonigle, Louise Paterson, Venkataramana Boyapati, Karen D Ersche, Remy Flechais, Shankar Kuchibatla, Antonio Metastasio, Csaba Orban, Filippo Passetti, Laurence Reed, Dana Smith, John Suckling, Eleanor Taylor, Trevor W Robbins, Anne Lingford-Hughes, David J Nutt, John F W Deakin, Rebecca Elliott
This corrects the article DOI: 10.1038/npp.2016.289.
August 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28696413/genome-wide-meta-analysis-of-copy-number-variations-with-alcohol-dependence
#11
A Sulovari, Z Liu, Z Zhu, D Li
Genetic association studies and meta-analyses of alcohol dependence (AD) have reported AD-associated single nucleotide polymorphisms (SNPs). These SNPs collectively account for a small portion of estimated heritability in AD. Recent genome-wide copy number variation (CNV) studies have identified CNVs associated with AD and substance dependence, suggesting that a portion of the missing heritability is explained by CNV. We applied PennCNV and QuantiSNP CNV calling algorithms to identify consensus CNVs in five AD cohorts of European and African origins...
July 11, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28695488/brain-structure-abnormalities-in-young-women-who-presented-conduct-disorder-in-childhood-adolescence
#12
Meenal Budhiraja, Ivanka Savic, Philip Lindner, Jussi Jokinen, Jari Tiihonen, Sheilagh Hodgins
The phenotype and genotype of antisocial behavior among females are different from those among males. Previous studies have documented structural brain alterations in males with antisocial behavior, yet little is known about the neural correlates of female antisocial behavior. The present study examined young women who had presented conduct disorder (CDW) prior to age 15 to determine whether brain abnormalities are present in adulthood and whether the observed abnormalities are associated with comorbid disorders or maltreatment that typically characterize this population...
July 10, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28686990/left-frontal-pole-theta-burst-stimulation-decreases-orbitofrontal-and-insula-activity-in-cocaine-users-and-alcohol-users
#13
Colleen A Hanlon, Logan T Dowdle, Brittany Correia, Oliver Mithoefer, Tonisha Kearney-Ramos, Daniel Lench, Millie Griffin, Raymond F Anton, Mark S George
BACKGROUND: Preclinical research has demonstrated a causal relationship between medial prefrontal cortex activity and cocaine self-administration. As a step towards translating those data to a neural circuit-based intervention for patients, this study sought to determine if continuous theta burst stimulation (cTBS) to the left frontal pole (FP), would attenuate frontal-striatal activity in two substance-dependent populations. METHODS: Forty-nine substance dependent individuals (25 cocaine, 24 alcohol) completed a single-blind, sham-controlled, crossover study wherein they received 6 trains of real or sham cTBS (110% resting motor threshold, FP1) each visit...
May 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28686985/somatic-health-care-utilization-by-patients-treated-for-substance-use-disorders
#14
Gerdien H de Weert-van Oene, Fabian Termorshuizen, Victor J A Buwalda, Eibert R Heerdink
INTRODUCTION: Patients with substance use disorder (SUD) are frequently suffering from co-occurring somatic disorders, increasing the risk of mortality. Somatic health care utilization (sHCU) often remains unknown to the physician during SUD treatment. This paper analyses sHCU and associated costs among patients in SUD treatment compared to matched, non-substance dependent controls. METHODS: Health care utilization data on 4972 SUD patients were matched to 19,846 controls by gender, birth year and ethnic origin...
June 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28685885/mental-health-and-substance-use-care-among-young-adults-before-and-after-affordable-care-act-aca-implementation-a-rural-and-urban-comparison
#15
Laura J Chavez, Kelly J Kelleher, Steven C Matson, Thomas M Wickizer, Deena J Chisolm
PURPOSE: Rural young adults experience greater unmet need for mental health (MH) and alcohol or drug (AOD) treatment and lower health insurance coverage than urban residents. It is unknown whether Affordable Care Act (ACA) reforms in 2010 (dependent coverage extended to age 26) or 2014 (Medicaid expansion) closed rural/urban gaps in insurance and treatment. The present study compared changes in rates of health insurance, MH treatment, and AOD treatment for rural and urban young adults over a period of ACA reforms...
July 7, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28682229/-epigenetic-mechanisms-and-alcohol-use-disorders-a-potential-therapeutic-target
#16
Rémi Legastelois, Jérôme Jeanblanc, Catherine Vilpoux, Erika Bourguet, Mickael Naassila
Alcohol use disorder is a devastating illness with a profound health impact, and its development is dependent on both genetic and environmental factors. This disease occurs over time and requires changes in brain gene expression. There is converging evidence suggesting that the epigenetic processes may play a role in the alcohol-induced gene regulations and behavior such as the intervention of DNA methylation and histone acetylation. Histone acetylation, like histone methylation, is a highly dynamic process regulated by two classes of enzymes: histone acetyltransferases and histone deacetylases (HDACs)...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/28682218/differences-in-the-rates-of-drug-polyconsumption-and-psychiatric-comorbidity-among-patients-with-cocaine-use-disorders-according-to-the-mental-health-service
#17
P Araos, Esperanza Vergara-Moragues, Francisco González-Saiz, María Pedraz, Nuria García-Marchena, Pablo Romero-Sanchiz, Juan Jesus Ruiz, Rafael Campos-Cloute, Antonia Serrano, Francisco Javier Pavón, Marta Torrens, Fernando Rodriguez De Fonseca
Cocaine continues to be a worldwide public health concern in Europe. To improve prognosis and intervention, it is necessary to understand the characteristics of the patients who depend on the services where they receive care. The objective is to analyze the differences among patients who use cocaine and between ambulatory and residential resources to better adapt treatment. This is a descriptive, observational study of two populations of cocaine users in treatment: the ambulatory therapeutic community (ATC) and the therapeutic community (TC)...
July 6, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28677274/examining-the-effect-of-social-bonds-on-the-relationship-between-adhd-and-past-arrest-in-a-representative-sample-of-adults
#18
Mark van der Maas, Nathan J Kolla, Patricia G Erickson, Christine M Wickens, Robert E Mann, Evelyn Vingilis
BACKGROUND: Several studies have found a connection between attentional deficit hyperactivity disorder (ADHD) and criminal behaviour in clinical and prison samples of adults, but there is a lack of representative general population data on this. AIM: To test relationships between histories of ADHD and arrest. Our main research question was whether any such relationship is direct or best explained by co-occurring variables, especially indicators of social bonds. METHOD: Data were from a sample of 5,376 adults (18+) representative of the general population of Ontario, Canada...
July 5, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28676779/alcohol-and-illicit-drug-use-are-important-factors-for-school-related-problems-among-adolescents
#19
Ove Heradstveit, Jens C Skogen, Jørn Hetland, Mari Hysing
The aim of this study was to investigate the association between alcohol and drug use, and school-related problems measured by low grade point average (GPA) and high school attendance. We also examined potential confounding effects from mental health problems. Although the issue is not new within current literature, the present study has its strengths in a large number of participants and the utilization of registry-based data on school-related functioning. A cross-sectional design is employed in this study using data from a large population-based sample of adolescents, youth@hordaland, in a linkage to official school registry data, and the current study presents data from N = 7,874...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28675639/prevalence-and-associations-of-psychological-distress-in-australian-junior-medical-officers
#20
Michelle W Lau, Wenlong Eric Li, Anthony Llewellyn, Allan M Cyna
AIMS: To determine the prevalence of psychological distress in Australian Junior Medical Officers (JMOs) and investigate the determinants associated with psychological distress over a three year (2014-2016) period. METHODS: JMOs were surveyed using the 2014-2016 JMO Census (n = 220, 399, and 466 each year, response rate approximately 15%). Levels of psychological distress were assessed using the Kessler Psychological Distress Scale (K10). A K10≥ 25 was chosen to indicate high psychological distress and this determinant was compared to various demographic and work-related factors...
July 4, 2017: Internal Medicine Journal
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