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Zoran Igrutinović, Amira Peco-Antić, Nedeljko Radlović, Biljana Vuletić, Slavica Marković, Ana Vujić, Zorica Rasković
INTRODUCTION: Pseudo-Bartter syndrome encompasses a heterogenous group of disorders similar to Bartter syndrome. We are presenting an infant with pseudo-Bartter syndrome caused by congenital chloride diarrhoea. CASE OUTLINE: A male newborn born in the 37th gestational week (GW) to young healthy and non-consanguineous parents. In the 35th GW a polyhydramnios with bowel dilatation was verified by ultrasonography. After birth he manifested several episodes of hyponatremic dehydration with hypochloraemia, hypokalaemia and metabolic alkalosis, so as Bartter syndrome was suspected treatment with indomethacin, spironolactone and additional intake of NaCl was initiated...
September 2011: Srpski Arhiv za Celokupno Lekarstvo
Marie-Pierre Otto, Valérie Cheminel, Lionel Crevon, Laurence Dubourg, Aoumeur Hadj-Aissa, Chantal Mounier, Jean-Michel Prevosto
We report the case of an asymptomatic patient presenting a severe chronic renal hypokalaemia. Once being sure of no diuretics use, two hypothesis can be mentioned for a normotensive patient presenting an hypokalaemia associated with a metabolic alcalosis: Bartter syndrome or Gitelman syndrome. The highlighting of low magnesaemia and hypocalciuria strongly concentrates the diagnosis on Gitelman syndrome. First, this has been strengthened by the results of renal function tests and later it has confirmed by molecular diagnosis with the identification of a known homozygous mutation on SLC12A3 gene...
July 2011: Annales de Biologie Clinique
F Neffati, I Hellara, M A Jelizi, J Bahri, W Douki, A Ben Amor, M F Najjar
We report the case of a 54-year-old man, without particular pathological antecedents admitted to the emergency of the university hospital of Monastir, for right renal colic. Radiography of the urinary tract without preparation and renal echography showed bilateral renal lithiasis and a right ureteral lithiasis. The interrogation revealed concept of vomiting after which the patient felt relieved. The biological assessment objectified an hypochloremic metabolic alcalosis, an increase in the anion gap, a severe impaired renal function of obstructive origin and an hypokaliemia...
July 2009: Annales de Biologie Clinique
Daniela Urich, Humberto Trejo, Alejandro Pezzulo, Juan Carlos Caraballo, Jeydith Gutiérrez, Ignacio Castro, Roberto Sánchez-de León
Hypocapnia/alkalosis is a consequence of several lung and metabolic pathologies. The aim of this study was to determine whether the increase of fluid filtration rate (FFR) that occurs during Hypocapnia/alkalosis circumstances is determined by hypocapnia, alkalosis or both. 7 groups were formed (N=36) using isolated rabbit lungs. Group 1: Control (PCO2 6%, pH: 7.35-7.45); Group 2 (n=6): Hypocapnia/Alkalosis (CO2 1%, pH: 7.9); Group 3 (n=6): Hypocapnia/Normo-pH (CO2 1% pH 7.35-7.45), Group 4 (n=6) Normocapnia/Alcalosis (CO2 6%, pH: 7...
June 2008: Investigación Clínica
K Mees, B Olzowy
The World Health Organisation estimates that about 40 million tourists every year climb to high (2,500-5,300 m) and extremely high altitudes (5,300-8,850 m). Thus altitude sickness and other health risks are increasing accordingly and so this fact requires clarification and advice for tourists in order to reduce the risks. That applies to the otolaryngologist, too. The non-traumatic health risks all result from the atmospheric conditions at high altitudes, in particular due to the lower atmospheric pressure...
April 2008: Laryngo- Rhino- Otologie
Jean-Michel Achard, Juliette Hadchouel, Sébastien Faure, Xavier Jeunemaitre
Several familial forms of hypertension have been identified, in which the mendelian pattern of inheritance indicated that hypertension results from the alteration of a single gene. This short review focuses on those rare monogenic disorders characterized by a low-renin profile. This common feature reflects that the causative mutations responsible for these disorders all result in an excessive sodium reabsorption in the aldosterone-dependent nephron. Low-renin familial hypertensions with hypokalemia encompass familial hyperaldosteronisms, in which aldosterone levels are elevated, and familial pseudohyperaldosteronisms, mimicking aldosteronism despite appropriately suppressed aldosterone levels...
April 2006: Advances in Chronic Kidney Disease
M Rehm, P F Conzen, K Peter, U Finsterer
About twenty years ago, Peter Stewart had already published his modern quantitative approach to acid-base chemistry. According to his interpretations, the traditional concepts of the mechanisms behind the changes in acid-base balance are considerably questionable. The main physicochemical principle which must be accomplished in body fluids, is the rule of electroneutrality. There are 3 components in biological fluids which are subject to this principle: a)Water, which is only in minor parts dissociated into H+ and OH-, b)"strong", i...
April 2004: Der Anaesthesist
Guillermo A Raimondi
The hypoxemia of acute respiratory distress syndrome (ARDS) depends chiefly upon shunt and ventilation-perfusion (VA/Q) inequality produced by fluid located in the interstitial space, alveolar collapse and flooding. Variables other tham inspired oxygen fraction and the underlying physiological abnormality can influence arterial oxygen partial pressure (PaO2). Changes in cardiac output, hemoglobin concentration, oxygen consumption and alcalosis can cause changes in PaO2 through their influence on mixed venous PO2...
2003: Medicina
G A Poliakova, T V Bezuglova, A R Garagezova
67 renal biopsies obtained in the course of adrenalectomy from patients with primary hyperaldosteronism, hypercorticism and pheochromocytoma were studied. Sclerotic affection of the arterioles and renal interstitium were found in long lasting adrenal arterial hypertension. This may cause residual postoperative hypertension. Endocrine nephropathy in primary hyperaldosteronism due to hypopotassemia and alcalosis manifests with vacuolar distrophy and atrophy of the epithelium, dilatation of tubular lumen, intratubular calcinosis and tubulointerstitial nephritis...
July 2002: Arkhiv Patologii
I M Trofymova, V Ie Dosenko, Iu V Byts'
In experiments on the acid-base imbalance modelling (acidosis induced with either lactate or ammonium chloride alcalosis induced with sodium hydrocarbonate) in rats, there were studied elastase activity, alpha-2-macroglobulin and alpha-1 proteinase inhibitor contents in blood serum and tissues of the aorta. The results obtained indicated that, in the models of both acidosis and alcalosis an disbalance between elastase and its inhibitors was observed. However, in NH4CL-acidosis in homogenates of aorta the inhibitors/elastase coefficient decreased at the expense of a reduction in contents of alpha-2-macroglobulin, while in lactate-acidosis it only decreased at the expense of an increase in elastase activity...
2001: Fiziolohichnyĭ Zhurnal
M Robello, R Balduzzi, A Cupello
Rat brain poly(A)(+) mRNA was injected into Xenopus oocytes. After 72-96 hr, GABA(A) receptors expressed in this heterologous system were studied by perfusion of GABA and recording of GABA evoked chloride current under voltage-clamp conditions. The GABA activated currents were blocked by bicuculline and enhanced by flunitrazepam. Acidic (6.4) extracellular pH (pH(e) ) augmented, whereas basic pH (8.4) decreased the current evoked by 100 microM GABA in the respect of the current evoked at pH 7.4. Concentration-response curves for GABA evoked chloride currents were built at the three pHs...
July 2000: International Journal of Neuroscience
V A Hryshchenko
The modelling of metabolic acidosis and alcalosis states proves that AAB is capable to influence on the haemoglobin parameters and its oxiform levels in the blood of newborn animals. The quantitative redistribution of the indicated haemoglobin forms in blood of the experimental animal is estimated as compensator process and is explained by their buffer properties. The investigated regularities revealed some aspects of adaptive mechanisms manifested during the abnormal exit of the newborn organism from the respiratory-metabolic acidosis state...
September 1999: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
W Schmidt, N Maassen
The knowledge about metabolism and muscular fatigue has been considerably improved during the recent years. Intramuscular pH should not generally be discussed as a factor of cellular fatigue as it has been shown to increase transiently at the beginning and to be very differently affected in ST-(6,9) and FT-fibers (6,2) at the end of exercise. During maximum exercise, we assume changes of muscle membrane potential due to increasing interstitial potassium concentrations as an important performance-limiting factor...
1998: Wiener Medizinische Wochenschrift
H Kümper
A dilated and dorsally displaced abomasum usually performs an additional counterclockwise rotation (1989-1994: 403 of 462 cases). A report is given about a repositioning technique that enables to correct nearly all cases of this counterclockwise rotation without removal of abomasal fluid. After the reposition the congested abomasal content flows to the intestine where it is resorbed, so that cases of right displaced abomasum (RDA, n = 275) recover without any parenteral fluid therapy within 24 to 48 hours. In cases of abomasal volvulus (AV, n = 187) the blood supply of the abomasum is disturbed, and after surgery the abomasal emptying is often delayed, due to a malfunction of the pylorus...
October 1995: Tierärztliche Praxis
H Kümper
A report is given about 462 cases (1989-1994) of abomasal displacement (RDA, n = 275) and abomasal volvulus (AV, n = 187) in cattle. The pathogenesis and the functional disturbances of abomasal hypotony, displacement, and volvulus are described. A right and dorsally displaced abomasum easily performs an additional rotation around a vertical axis. In 99% of all cases this rotation is performed to the left (counter-clockwise, seen from rear) and the duodenum twines round the abomasal fundus, where it is compressed and trapped between the abomasum and the omasum...
August 1995: Tierärztliche Praxis
J Zimmermann, M Reincke, L Schramm, J Harlos, B Allolio
BACKGROUND: Hypokalemia due to renal potassium wasting in the absence of hypertension, moderate metabolic alkalosis, hyperreninism and hyperaldosteronism suggest the presence of Bartter's syndrome. The underlying cause is an inherited defect of sodium chloride reabsorption in the thick ascending limb of Henle. A differential diagnosis of Bartter's syndrome is Gitelman's syndrome, another hypokalemia-hypomagnesemia syndrome, which is thought to be caused by a transport defect in the distal tube...
December 15, 1994: Medizinische Klinik
R Hürlimann, M Enzler, R O Binswanger, C Meyenberger
A 62 year old woman presented with the symptoms of a gastric outlet obstruction together with severe metabolic hypochloremic alcalosis. A gallstone in the duodenum with gastric outlet obstruction was diagnosed by abdominal ultrasonography. In a one-stage surgical procedure, cholecystectomy, enterolithotomy and repair of the cholecytoduodenal fistula were performed. The postoperative course was uneventful. Pathogenesis, clinical findings, diagnostic procedures and therapeutic options of gastric outlet obstruction secondary to a gallstone impacted in the duodenal bulb (Bouveret's Syndrome) are discussed...
August 1995: Zeitschrift Für Gastroenterologie
J O Habeck, A Honig, C Pfeiffer, M Schmidt
Size, anatomical position and blood supply of the carotid bodies were studied by light microscopic methods in spontaneously hypertensive rats of the Okamoto-strain (SHR) and in normotensive Wistar rats (NWR) of a random-bred strain. In both groups of animals the single carotid body was usually supplied by only one glomic artery which most frequently derived from the external carotid artery, more rarely from the occipital artery and very seldom from the internal carotid artery. In general the carotid bodies were of ellipsoide shape and compact structure and as a rule closely located to the internal carotid artery...
1981: Anatomischer Anzeiger
I Nakao, T Ito, N Kasai
In outlining the pathology of various electrolyte metabolism abnormalities in cancer patients we considered the main clinical points between pathologies and emergency treatment. In regard to sodium (Na+) metabolism, one pathologic state that requires our attention is hypernatremia. Hypernatremia is accompanied with dehydration and is due to water loss, vomiting, diarrhea and renal insufficiency. One of the major causes of this condition is lack of the antidiuretic hormone due to intracranial metastasis of the tumor...
February 1983: Gan to Kagaku Ryoho. Cancer & Chemotherapy
V I Bragin, E N Danilov, G A Rusanov, N A Shcherbakha, V I Aleksandrov
The oxygen-transport function of blood in hyperoxia and acute disturbances of the acid-alkali condition was studied in "oxygenator--desoxygenator" as a model. It has been established that in acidosis there occurs decreased intensity of glycolysis in erythrocytes, accumulation of 2,3 diphosphoglyceric acid which decreases affinity of hemoglobin for oxygen. It does not occur in alcalosis.
January 1980: Vestnik Khirurgii Imeni I. I. Grekova
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