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https://www.readbyqxmd.com/read/29141117/tunable-energy-landscapes-to-control-pathway-complexity-in-self-assembled-n-heterotriangulenes-living-and-seeded-supramolecular-polymerization
#1
Jorge S Valera, Rafael Gómez, Luis Sánchez
Herein, the synthesis and self-assembling features of N-heterotriangulenes 1-3 decorated in their periphery with 3,4,5-trialkoxy-N-(alkoxy)benzamide moieties that enable kinetic control of the supramolecular polymerization process are described. The selection of an appropriate solvent results in a tunable energy landscape in which the relative energy of the different monomeric or aggregated species can be regulated. Thus, in a methylcyclohexane/toluene (MCH/Tol) mixture, intramolecular hydrogen-bonding interactions in the peripheral side units favor the formation of metastable inactivated monomers that evolve with time at precise conditions of concentration and temperature...
November 15, 2017: Small
https://www.readbyqxmd.com/read/29140606/mr-textural-analysis-on-t2-flair-images-for-the-prediction-of-true-oligodendroglioma-by-the-2016-who-genetic-classification
#2
Wenting Rui, Yan Ren, Yin Wang, Xinyi Gao, Xiao Xu, Zhenwei Yao
BACKGROUND: The genetic status of 1p/19q is important for differentiating oligodendroglioma, isocitrate-dehydrogenase (IDH)-mutant, and 1p/19q-codeleted from diffuse astrocytoma, IDH-mutant according to the 2016 World Health Organization (WHO) criteria. PURPOSE: To assess the value of magnetic resonance textural analysis (MRTA) on T2 fluid-attenuated inversion recovery (FLAIR) images for making a genetically integrated diagnosis of true oligodendroglioma by WHO guidelines...
November 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29140137/v%C3%AC-o2-and-muscle-deoxygenation-kinetics-during-skating-comparison-between-slide-board-and-treadmill-skating
#3
Tatiane Piucco, Rogério Soares, Fernando Diefenthaeler, Guillaume Millet, Juan Murias
PURPOSE: this study aimed to compare the oxygen uptake (V̇O2) kinetics during skating on a treadmill and skating on a slide board and discuss potential mechanisms that might control the V̇O2 kinetics responses during skating. METHODS: breath-by-breath pulmonary V̇O2 and near-infrared spectroscopy-derived muscle deoxygenation ([HHbMb]) were monitored continuously in 12 well-trained young long track speed skaters. On-transient V̇O2 and [HHbMb] responses to skating on a treadmill and skating on a slide board at 80% of the estimated gas exchange threshold were fitted as mono-exponential function...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29140092/determinants-and-expansion-of-specificity-in-a-trichothecene-udp-glucosyltransferase-from-oryza-sativa
#4
Karl M Wetterhorn, Kaitlyn Gabardi, Herbert Michlmayr, Alexandra Malachova, Mark Busman, Susan Patricia McCormick, Franz Berthiller, Gerhard Adam, Ivan Rayment
Family 1 UDP-glycosyltransferases in plants (UGTs) primarily form glucose conjugates of small molecules and, besides other functions, play a role in detoxification of xenobiotics. Indeed, overexpression of a barley UGT in wheat has been shown to control Fusarium head blight, where this is a plant disease of global significance that leads to reduced crop yields and contamination with trichothecene mycotoxins such as deoxynivalenol (DON), T-2 toxin and many other structural variants. The UGT Os79 from rice has emerged as a promising candidate for inactivation of mycotoxins on account of its ability to glycosylate DON, nivalenol and hydrolyzed T-2 toxin (HT-2)...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29138537/development-of-novel-ultrashort-antimicrobial-peptide-nanoparticles-with-potent-antimicrobial-and-antibiofilm-activities-against-multidrug-resistant-bacteria
#5
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Qosay Al-Balas
Conventional antibiotics are facing strong microbial resistance that has recently reached critical levels. This situation is leading to significantly reduced therapeutic potential of a huge proportion of antimicrobial agents currently used in clinical settings. Antimicrobial peptides (AMPs) could provide the medical community with an alternative strategy to traditional antibiotics for combating microbial resistance. However, the development of AMPs into clinically useful antibiotics is hampered by their relatively low stability, toxicity, and high manufacturing costs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29138240/kinetics-of-h2o2-driven-degradation-of-chitin-by-a-bacterial-lytic-polysaccharide-monooxygenase
#6
Silja Kuusk, Bastien Bissaro, Piret Kuusk, Zarah Forsberg, Vincent G H Eijsink, Morten Sørlie, Priit Väljamäe
Lytic polysaccharide monooxygenases (LPMOs) catalyze the oxidative cleavage of glycosidic bonds in recalcitrant polysaccharides, such as cellulose and chitin, and are of interest in biotechnological utilization of these abundant biomaterials. It has recently been shown that LPMOs can use H2O2, instead of O2, as a co-substrate. This peroxygenase-like reaction by a mono-copper enzyme is unprecedented in nature and opens new avenues in chemistry and enzymology. Here, we provide the first detailed kinetic characterization of chitin degradation by the bacterial LPMO chitin-binding protein CBP21 using H2O2 as co-substrate...
November 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29137929/enhanced-performance-and-kinetics-of-marine-anammox-bacteria-mab-treating-nitrogen-rich-saline-wastewater-with-mn-ii-and-ni-ii-addition
#7
Jin Li, Li Feng, Zhimin Qiang, Huiyu Dong, Dan Wang
A sequencing batch reactor (SBR) was used to study nitrogen removal performance of marine anammox bacteria (MAB) with Mn(II) and Ni(II) addition. The reactor was operated at 25 ± 0.5 °C with influent pH of 7.5 ± 0.1. Optimal ammonium removal efficiencies (AREs) were 93.95% and 93.18% with 0.05 mM Mn(II) and 0.025 mM Ni(II), respectively. Both Mn(II) and Ni(II) played key roles in treating nitrogen-rich saline wastewater. However, the effect resulting from Ni(II) was far stronger than Mn(II)...
November 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29137786/sonochemical-synthesis-of-fe3o4-nh2-mesoporous-silica-polypyrrole-pd-a-core-double-shell-nanocomposite-for-catalytic-applications
#8
Youssef Snoussi, Stéphane Bastide, Manef Abderrabba, Mohamed M Chehimi
There is a growing interest in sonochemistry for either the controlled design of nanostructured materials or for the synthesis of polymers and polymer composites. It is fast and highly efficient method that provides materials with exceptional and enhanced structural and chemical properties. Herein, we take advantage of the versatile sonochemical process in order to design core/double layered shell nanocomposite denoted by Fe3O4@NH2-mesoporous silica@ PPy/Pd. This magnetic, multicomponent material was designed in a three-step sono-process: (i) synthesis of magnetic core, (ii) cure of mesoporous silica, and (iii) sonochemical deposition of PPy/Pd...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137745/intensification-of-heat-transfer-during-mild-thermal-treatment-of-dry-cured-ham-by-using-airborne-ultrasound
#9
M Contreras, J Benedito, J Bon, J V Garcia-Perez
The application of power ultrasound (PuS) could be used as a novel technology with which to intensify thermal treatments using hot air. Mild thermal treatments have been applied to improve the soft texture of dry-cured ham caused by defective processing. In this regard, the aim of this study was to assess the kinetic intensification linked to the application of airborne PuS in the mild thermal treatment using hot air of dry-cured ham. For this purpose, vacuum packed cylindrical samples (2.52±0.11cm in diameter and 1...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137119/dynamic-reorganization-of-the-cytoskeleton-during-apoptosis-the-two-coffins-hypothesis
#10
REVIEW
Suleva Povea-Cabello, Manuel Oropesa-Ávila, Patricia de la Cruz-Ojeda, Marina Villanueva-Paz, Mario de la Mata, Juan Miguel Suárez-Rivero, Mónica Álvarez-Córdoba, Irene Villalón-García, David Cotán, Patricia Ybot-González, José A Sánchez-Alcázar
During apoptosis, cells undergo characteristic morphological changes in which the cytoskeleton plays an active role. The cytoskeleton rearrangements have been mainly attributed to actinomyosin ring contraction, while microtubule and intermediate filaments are depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reorganized during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Evidence suggests that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis...
November 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136384/field-effect-modulation-of-heterogeneous-charge-transfer-kinetics-at-back-gated-2d-mos2-electrodes
#11
Yan Wang, Chang-Hyun Kim, Youngdong Yoo, James E Johns, C Daniel Frisbie
The ability to improve and to modulate the heterogeneous charge transfer kinetics of two dimensional (2D) semiconductors, such as MoS2, is a major challenge for electrochemical and photoelectrochemical applications of these materials. Here we report a continuous and reversible physical method for modulating the heterogeneous charge transfer kinetics at a monolayer MoS2 working electrode supported on a SiO2/p-Si substrate. The heavily doped p-Si substrate serves as a back gate electrode; application of a gate voltage (VBG) to p-Si tunes the electron occupation in the MoS2 conduction band and shifts the conduction band edge position relative to redox species dissolved in electrolyte in contact with the front side of the MoS2...
November 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/29136023/modifications-of-hemoglobin-and-myoglobin-by-maillard-reaction-products-mrps
#12
Aristos Ioannou, Constantinos Varotsis
High performance liquid chromatography (HPLC) coupled with a Fraction Collector was employed to isolate Maillard reaction products (MRPs) formed in model systems comprising of asparagine and monosaccharides in the 60-180°C range. The primary MRP which is detected at 60°C is important for Acrylamide content and color/aroma development in foods and also in the field of food biotechnology for controlling the extent of the Maillard reaction with temperature. The discrete fractions of the reaction products were reacted with Hemoglobin (Hb) and Myoglobin (Mb) at physiological conditions and the reaction adducts were monitored by UV-vis and Attenuated Total Reflection-Fourier transform infrared (FTIR) spectrophotometry...
2017: PloS One
https://www.readbyqxmd.com/read/29135783/beyond-the-bottom-of-the-foot-topographic-organization-of-the-foot-dorsum-in-walking
#13
Taryn Klarner, Gregory E P Pearcey, Yao Sun, Trevor S Barss, Chelsea Kaupp, Bridget Munro, Nick Frank, E Paul Zehr
INTRODUCTION: Sensory feedback from the foot dorsum during walking has only been studied globally by whole nerve stimulation. Stimulating the main nerve innervating the dorsal surface produces a functional stumble corrective response that is phase-dependently modulated. We speculated that effects evoked by activation of discrete skin regions on the foot dorsum would be topographically organized, as with the foot sole. METHODS: Nonnoxious electrical stimulation was delivered to five discrete locations on the dorsal surface of the foot during treadmill walking...
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29134859/an-injectable-and-self-healing-hydrogel-for-spatiotemporal-protein-release-via-fragmentation-after-passing-through-needles
#14
Ik Sung Cho, Tooru Ooya
A dynamic hydrogel formulated by mixing a glycol chitosan (GC) and an oxidized dextran (Odex) were studied for protein-controlled release in conjunction with the hydrogel fragmentation. A series of injectable dynamic hydrogels were derived from GC and Odex upon simple mixing without the addition of chemical crosslinking agents. The gelation readily took place at physiological pH and temperature. The influence of the concentration of GC and Odex on the gelation time, mechanical properties, water content, in vitro degradation were investigated...
November 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29134458/animal-cell-expression-systems
#15
M Butler, Ing U Reichl
The glycan profile of therapeutic recombinant proteins such as monoclonal antibodies is a critical quality attribute, which affects the efficacy of the final product. The cellular glycosylation process during protein expression is dependent upon a number of factors such as the availability of substrates in the media, the intracellular content of nucleotide sugars, and the enzyme repertoire of the host cells. In order to control the variability of glycosylation it is important to understand the critical process parameters and their acceptable range of values to enable reproducible production of proteins with a predetermined glycan profile providing the desired biological function or therapeutic effect...
October 3, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29133841/nanopore-electric-snapshots-of-an-rna-tertiary-folding-pathway
#16
Xinyue Zhang, Dong Zhang, Chenhan Zhao, Kai Tian, Ruicheng Shi, Xiao Du, Andrew J Burcke, Jing Wang, Shi-Jie Chen, Li-Qun Gu
The chemical properties and biological mechanisms of RNAs are determined by their tertiary structures. Exploring the tertiary structure folding processes of RNA enables us to understand and control its biological functions. Here, we report a nanopore snapshot approach combined with coarse-grained molecular dynamics simulation and master equation analysis to elucidate the folding of an RNA pseudoknot structure. In this approach, single RNA molecules captured by the nanopore can freely fold from the unstructured state without constraint and can be programmed to terminate their folding process at different intermediates...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29133800/interfaces-between-hexagonal-and-cubic-oxides-and-their-structure-alternatives
#17
Hua Zhou, Lijun Wu, Hui-Qiong Wang, Jin-Cheng Zheng, Lihua Zhang, Kim Kisslinger, Yaping Li, Zhiqiang Wang, Hao Cheng, Shanming Ke, Yu Li, Junyong Kang, Yimei Zhu
Multi-layer structure of functional materials often involves the integration of different crystalline phases. The film growth orientation thus frequently exhibits a transformation, owing to multiple possibilities caused by incompatible in-plane structural symmetry. Nevertheless, the detailed mechanism of the transformation has not yet been fully explored. Here we thoroughly probe the heteroepitaxially grown hexagonal zinc oxide (ZnO) films on cubic (001)-magnesium oxide (MgO) substrates using advanced scanning transition electron microscopy, X-ray diffraction and first principles calculations, revealing two distinct interface models of (001) ZnO/(001) MgO and (100) ZnO/(001) MgO...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29132258/effect-of-three-pretreatment-techniques-on-the-chemical-composition-and-on-the-methane-yields-of-opuntia-ficus-indica-prickly-pear-biomass
#18
P S Calabrò, E Catalán, A Folino, A Sánchez, D Komilis
Opuntia ficus-indica (OFI) is an emerging biomass that has the potential to be used as substrate in anaerobic digestion. The goal of this work was to investigate the effect of three pretreatment techniques (thermal, alkaline, acidic) on the chemical composition and the methane yield of OFI biomass. A composite experimental design with three factors and two to three levels was implemented, and regression modelling was employed using a total of 10 biochemical methane potential (BMP) tests. The measured methane yields ranged from 289 to 604 NmL/gVSadded; according to the results, only the acidic pretreatment (HCl) was found to significantly increase methane generation...
November 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/29131973/investigation-of-the-photocatalytic-transformation-of-acesulfame-k-in-the-presence-of-different-tio2-based-materials
#19
M J López-Muňoz, A Daniele, M Zorzi, C Medana, P Calza
The photocatalytic transformation of acesulfame K - an artificial sweetener that has gained popularity over the last decades for being a calorie-free additive in food, beverages and several pharmaceutical products - was studied using three different photocatalysts, the benchmark TiO2-P25 and two other forms of synthetized titanium oxides named TiO2-SG1 and TiO2-SG2. The two latter materials were synthesized by a sol gel process in which the hydrolysis rate of titanium n-butoxide was controlled by the water formed in situ through an esterification reaction between ethanol and acetic acid...
November 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29131957/excimer-formation-dynamics-of-dipyrenyldecane-in-structurally-different-ionic-liquids
#20
Anita Yadav, Siddharth Pandey
Ionic liquids, being composed of ions alone, may offer alternate pathways for molecular aggregation. These pathways could be controlled by the chemical structure of the cation and the anion of the ionic liquids. Intramolecular excimer formation dynamics of a bifluorophoric probe, 1,3-bis(1-pyrenyl)decane [1Py(10)1Py], where the fluorophoric pyrene moieties are separated by a long decyl chain, is investigated in seven different ionic liquids in 10 - 90 °C temperature range. The long alkyl separator allows for ample interaction with the solubilizing milieu prior to the formation of the excimer...
November 13, 2017: Journal of Physical Chemistry. B
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