keyword
MENU ▼
Read by QxMD icon Read
search

kinetic control

keyword
https://www.readbyqxmd.com/read/28821139/charge-functionalized-and-mechanically-durable-composite-cryogels-from-q-nfc-and-cs-for-highly-selective-removal-of-anionic-dyes
#1
Yufei Chen, Jing Ru, Biyao Geng, Haiying Wang, Congcong Tong, Chungui Du, Shengchun Wu, Hongzhi Liu
A composite cryogel was prepared from quaternized nanofibrillated cellulose (Q-NFC) and chitosan (CS) through a combination of freeze-drying and cross-linking with epichlorohydrin. The specific surface area of the composite cryogel was approximately two times that of Q-NFC cryogel. And the composite cryogel exhibited superior adsorption properties of anionic dyes than either the Q-NFC or CS cryogel controls. The adsorption isotherm well fitted the Langmuir model with the maximum theoretical adsorption capacity up to 473...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821135/exploring-pullulan-poly-vinyl-alcohol-interpenetrating-network-microspheres-as-controlled-release-drug-delivery-device
#2
Saundray Raj Soni, Animesh Ghosh
In the present study, interpenetrating polymeric network (IPN) microsphere was prepared using glutaraldehyde assisted water-in-oil emulsion crosslinking method for controlled delivery of pirfenidone, the only chemical entity approved by US FDA for the treatment of Idiopathic Pulmonary Fibrosis (IPF). In our study, the natural biopolymer pullulan was harnessed in combination with synthetic polymer PVA for drug delivery applications. The prepared microspheres were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, solid state (13)C nuclear magnetic resonance and field emission scanning electron microscopy...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821099/xyloglucan-gelation-induced-by-enzymatic-degalactosylation-kinetics-and-the-effect-of-the-molar-mass
#3
Caroline Novak Sakakibara, Maria Rita Sierakowski, Christophe Chassenieux, Taco Nicolai, Rilton Alves de Freitas
Gelation kinetics of aqueous solutions of xyloglucan (XG) extracted from H. courbaril seeds were investigated, in-situ, during enzymatic removal of galactose units by oscillatory shear rheological measurements, at different XG and enzyme (β-galactosidase) concentrations. Increasing the enzyme concentration (Cenz) led to an increase of the gelation rate. Master curves of the evolution of the storage shear modulus at different Cenz could be formed by time-Cenz superposition showing that Cenz influenced the kinetics, but not the gelation process and the final gel stiffness...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820980/isotope-fractionation-in-phase-transfer-processes-under-thermodynamic-and-kinetic-control-implications-for-diffusive-fractionation-in-aqueous-solution
#4
Frank-Dieter Kopinke, Anett Georgi, Ulf Roland
Diffusive isotope fractionation of organic compounds in aqueous solution was investigated by means of liquid-liquid and liquid-gas partitioning experiments under kinetic control. The two-film model was used to describe phase-transfer kinetics. It assumes the diffusion of solutes across a stagnant water boundary layer as the rate-controlling step. For all investigated solutes (benzene-D0 and -D6, toluene-D0, -D5, and -D8, cyclohexane-D0 and -D12), there was no significant observable fractionation effect between nondeuterated and perdeuterated isotopologues, resulting in a ratio of diffusion coefficients Dlight: Dheavy=1...
August 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28820938/multi-scale-simulation-of-receptor-drug-association-kinetics-application-to-neuramidase-inhibitors
#5
Fabian Zeller, Manuel P Luitz, Rainer Bomblies, Martin Zacharias
A detailed understanding of the drug-receptor association process is of fundamental importance for drug design. Due to the long timescales of typical binding kinetics, the atomistic simulation of the ligand traveling from bulk solution into the binding site is still computationally challenging. In this work, we apply a multi-scale approach of combined molecular dynamics (MD) and Brownian dynamics (BD) simulations to investigate association pathway ensembles for the two prominent H1N1 neuraminidase inhibitors oseltamivir and zanamivir...
August 18, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28820850/ultrasonographic-findings-in-the-vitreous-of-patients-with-age-related-macular-degeneration-treated-with-intravitreal-anti-vascular-endothelial-growth-factor-injections
#6
Tamara Mato-Gondelle, Manuel F Bande, Laura Paniagua, María J Rodríguez-Cid, Maximino Abraldes, Maribel Fernández, María J Blanco-Teijeiro, Antonio Piñeiro
PURPOSE: We aimed to assess the relationship of repeated intravitreal injection of anti-vascular endothelial growth factor, the main treatment for exudative age-related macular degeneration, with changes in vitreous ultrasonographic findings in patients with age-related macular degeneration. METHODS: We retrospectively collected data from 41 patients (41 age-related macular degeneration eyes, 41 control eyes) on age, sex, number of injections, and type of anti-vascular endothelial growth factor (ranibizumab, aflibercept)...
August 16, 2017: Retina
https://www.readbyqxmd.com/read/28820526/silica-nanoparticle-monolayers-on-a-macroion-modified-surface-formation-mechanism-and-stability
#7
M Morga, Z Adamczyk, D Kosior
Even though silica nanoparticles and their monolayers find a broad field of applications, only a few studies providing a quantitative description of silica nanoparticle deposition at solid/liquid interfaces have been reported in the literature. Given the deficit of reliable experimental data, the goal of this work is to acquire thorough physicochemical characteristics of amorphous silica nanoparticle deposition. Silica nanoparticle monolayers of controlled coverage were formed on macroion (PAH)-modified mica...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28820263/hydrodynamic-steering-in-protein-association-revisited-surprisingly-minuscule-effects-of-considerable-torques
#8
Jan Marek Antosiewicz, Kamil Kamiński, Maciej Dlugosz
We investigate the previously postulated hydrodynamic steering phenomenon, resulting from complication of molecular shapes, its magnitude and possible relevance for protein-ligand and protein-protein diffusional encounters, and the kinetics of diffusion-controlled association. We consider effects of hydrodynamic interactions in a prototypical model system consisting of a cleft enzyme and an elongated substrate, and real protein-protein complexes, that of barnase and barstar, and human growth hormone and its binding protein...
August 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28819051/the-effects-of-8-weeks-voluntary-wheel-running-on-the-contractile-performance-of-isolated-locomotory-soleus-and-respiratory-diaphragm-skeletal-muscle-during-early-ageing
#9
Jason Tallis, Matthew F Higgins, Frank Seebacher, Val M Cox, Michael J Duncan, Rob S James
Decreased skeletal muscle performance with increasing age is strongly associated with reduced mobility and quality of life. Increased physical activity is a widely prescribed method of reducing the detrimental effects of ageing on skeletal muscle contractility. The present study uses isometric and work loop testing protocols to uniquely investigate the effects of 8 weeks of voluntary wheel running on the contractile performance of isolated dynapenic soleus and diaphragm muscles of 38 week old CD1 mice. When compared to untrained controls, voluntary wheel running induced significant improvements in maximal isometric stress and work loop power, a reduced resistance to fatigue, but greater cumulative work during fatiguing work loop contractions in isolated muscle...
August 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28818984/pseudo-reference-regions-for-glial-imaging-with-11-c-pbr28-investigation-in-two-clinical-cohorts
#10
Daniel Strakis Albrecht, Marc David Normandin, Sergey Shcherbinin, Dustin W Wooten, Adam J Schwarz, Nicole R Zurcher, Vanessa N Barth, Nicolas J Guehl, Oluwaseun Johnson-Akeju, Nazem Atassi, Mattia Veronese, Federico Turkheimer, Jacob M Hooker, Marco Luciano Loggia
The translocator protein (TSPO) is a commonly used imaging target to investigate neuroinflammation. While TSPO imaging demonstrates great promise, its signal exhibits substantial interindividual variability, which needs to be accounted for to uncover group effects that are truly reflective of neuroimmune activation. Recent evidence suggests that relative metrics computed using pseudo-reference approaches can minimize within-group variability, and increase sensitivity to detect physiologically meaningful group differences...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818684/t-cell-mediated-rejection-of-human-cd34-cells-is-prevented-by-costimulatory-blockade-in-a-xenograft-model
#11
A L Oh, D Mahmud, B Nicolini, N Mahmud, V Senyuk, P R Patel, E Bonetti, M Arpinati, Jlm Ferrara, D Rondelli
A xenograft model of stem cell rejection was developed by co-transplantating human CD34+ and allogeneic CD3+ T cells into NOD-scid ɣ-chain(null) (NSG) mice. T cells caused graft failure when transplanted at any CD34:CD3 ratio between 1:50 to 1:0.1. Kinetics experiments showed that two weeks after transplantation CD34+ cells engrafted the marrow and T cells expanded in the spleen. Then at four weeks only memory T cells populated both sites and rejected CD34+ cells. Blockade of T cell costimulation was tested by injecting the mice with abatacept (CTLA4-IgG1) from day -1 to +27 (Group A), or from day -1 to +13 (Group B), or from day +14 to +28 (Group C)...
August 14, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28818579/developing-integrated-pbpk-pd-coupled-mechanistic-pathway-model-mirna-bdnf-an-approach-towards-system-toxicology
#12
Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar
Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field of toxicology via its coupling to the Physiological based Pharmacokinetics and Pharmacodynamics (PBPK/PD) model.This expansion framework of integrated PBPK/PD coupled mechanistic system pathway model can be called as system toxicology that describes the kinetics of both -the chemicals and -biomolecules, help us to understand the dynamic and steady-state behaviors of molecular pathways under perturbed condition...
August 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28817615/genotoxic-effects-of-roundup-full-ii%C3%A2-on-lymphocytes-of-chaetophractus-villosus-xenarthra-mammalia-in-vitro-studies
#13
Juan Pablo Luaces, Luis Francisco Rossi, Mónica Gabriela Chirino, Melanie Browne, María Susana Merani, Marta Dolores Mudry
In Argentina, Chaetophractus villosus has a wide distribution that overlaps with agricultural areas where soybean is the predominant crop. In such areas the pesticide Roundup Full II® (RU) is widely applied. The genotoxic effect of its active ingredient glyphosate (RU is 66.2% glyphosate) on the peripheral blood lymphocytes of C. villosus was tested over a range of concentrations (280, 420, 560, 1120 μmol/L). Culture medium without glyphosate served as negative control, while medium containing mitomycin C served as positive control...
2017: PloS One
https://www.readbyqxmd.com/read/28817564/cell-cycle-related-kinase-ccrk-regulates-ciliogenesis-and-hedgehog-signaling-in-mice
#14
Ashley Snouffer, Desmond Brown, Hankyu Lee, Jonathon Walsh, Floria Lupu, Ryan Norman, Karl Lechtreck, Hyuk Wan Ko, Jonathan Eggenschwiler
The Hedgehog (Hh) signaling pathway plays a key role in cell fate specification, proliferation, and survival during mammalian development. Cells require a small organelle, the primary cilium, to respond properly to Hh signals and the key regulators of Hh signal transduction exhibit dynamic localization to this organelle when the pathway is activated. Here, we investigate the role of Cell Cycle Related kinase (CCRK) in regulation of cilium-dependent Hh signaling in the mouse. Mice mutant for Ccrk exhibit a variety of developmental defects indicative of inappropriate regulation of this pathway...
August 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28815365/the-effect-of-dichlorvos-on-control-of-drosophila-and-its-safety-evaluation-under-different-application-methods
#15
Yue Zhang, Jing Zheng You, You Zhou, Pei Wen Zhang, De Qiang Qin, Zhi Xiang Zhang
Drosophila is a common strawberry pest. In this work, toxicities of the 77.5% EC dichlorvos to 3rd instar larvae and adults of drosophila were evaluated through indoor bioassays and field bioassays, respectively. To insure the safety, dichlorvos dissipation and terminal residue in strawberry by different application methods under field conditions were determined by high-performance liquid chromatography. The decline curves of dichlorvos residues in strawberry corresponded with first-order kinetics, and dichlorvos dissipated rapidly in strawberry with half-life (t1/2) of 7...
August 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28815297/leukocyte-reduced-platelet-rich-plasma-increases-proliferation-of-tenocytes-treated-with-prednisolone-a-cell-cycle-analysis
#16
Franz Hilber, Markus Loibl, Siegmund Lang, Maximilian Kerschbaum, Gero Brockhoff, Peter Angele, Johannes Zellner, Paul Schmitz, Michael Nerlich, Michael Worlicek
INTRODUCTION: The purpose of this study was to evaluate the effect of allogenic leukocyte-reduced platelet-rich plasma on human tenocytes after treatment with prednisolone and to develop a standardization of its application for clinical practice. METHODS: A leukocyte-reduced PRP was produced using the Arthrex Double Syringe (Arthrex, Inc., Naples, FL, USA), in a modified single-spin separation method. Human tenocytes were isolated from discarded rotator cuff segments...
August 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28815235/growth-kinetics-and-mechanisms-of-multinary-copper-based-metal-sulfide-nanocrystals
#17
Keqiang Chen, Jing Zhou, Wen Chen, Qiaohui Zhong, Tingqiang Yang, Xue Yang, Chunyu Deng, Yueli Liu
Multinary copper-based metal sulfide (Cu-M-S) nanocrystals (NCs) usually have high absorption coefficients and near-optimum direct band gaps, which have been considered as novel photo-absorption materials for quantum dot-sensitized solar cells (QDSCs) and hole-transport materials for perovskite solar cells (PSCs). However, the formation and phase transformation mechanisms of Cu-M-S NCs during the solution-based preparing approaches are complicated. Herein, Cu-M-S NCs, including Cu2ZnSnS4 (CZTS), Cu2SnS3 (CTS), CuInS2 (CIS), and CuSbS2 (CAS), have been synthesized through solution-based hot-injection methods...
August 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28813993/the-influence-of-a-user-adaptive-prosthetic-knee-on-planned-gait-termination
#18
Erik C Prinsen, Marc J Nederhand, Bart F Koopman, Johan S Rietman
The added value of user-adaptive prosthetic knees has been predominantly evaluated in level walking or ramp/stair negotiation. Previous studies indicate that the activity pattern of individuals with an amputation mainly consists of short periods of continuous walking, indicating that a high percentage of ambulatory activity involves gait termination. The potential added value of user-adaptive prosthetic knees in gait termination has not been studied yet. Ten individuals with an amputation were measured with their own non-microprocessor controlled prosthetic knee and with the Rheo Knee II (a user-adaptive prosthetic knee)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813868/relationship-between-assistive-torque-and-knee-biomechanics-during-exoskeleton-walking-in-individuals-with-crouch-gait
#19
Zachary F Lerner, Diane L Damiano, Thomas C Bulea
Crouch or "flexed knee" gait is a pathological gait pattern affecting many individuals with cerebral palsy. One proposed method to alleviate crouch is to provide robotic assistance to knee extension during walking. The purpose of this study was to evaluate how the magnitude of knee extensor torque affects knee kinematics, kinetics, and muscle activity. Motion capture, ground reaction force and electromyography data were collected while four participants with crouch gait from cerebral palsy walked with assistance from a novel robotic exoskeleton on an instrumented treadmill...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813858/active-impedance-control-of-a-knee-joint-orthosis-during-swing-phase
#20
Fatima El Zahraa Wehbi, Weiguang Huo, Yacine Amirat, Maher El Rafei, Mohamad Khalil, Samer Mohammed
In this paper, an active impedance control strategy for a knee-joint orthosis is proposed to assist individuals suffering from lower-limb muscular weaknesses during the swing phase of walking activities. The goal of the proposed strategy is to decrease the human effort required for ensuring a successful knee joint movement during walking without sacrificing the wearer's control priority. In this study, a gait-phase based desired knee-joint admittance model is designed by analyzing the kinematic and kinetic characteristics of the wearer's shank-foot segment during walking...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
keyword
keyword
47131
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"