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https://www.readbyqxmd.com/read/29786938/inhibition-and-kinetic-studies-of-lignin-degrading-enzymes-of-ganoderma-boninense-by-naturally-occurring-phenolic-compounds
#1
Arthy Surendran, Yasmeen Siddiqui, Halimi Mohd Saud, Nusaibah Syd Ali, Sivakumar Manickam
AIM: Lignolytic (Lignin degrading) enzyme, from oil palm pathogen Ganoderma boninense Pat. (Syn G. orbiforme (Ryvarden), is involved in the detoxification and the degradation of lignin in the oil palm and is the rate-limiting step in the infection process of this fungus. Active inhibition of lignin degrading enzymes secreted by G. boninense by various naturally occurring phenolic compounds and estimation of efficiency on pathogen suppression was aimed at. METHODS AND RESULTS: In our work, ten naturally occurring phenolic compounds were evaluated for their inhibitory potential towards the lignolytic enzymes of G...
May 22, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29785557/highly-sensitive-ethanol-chemical-sensor-based-on-novel-ag-doped-mesoporous-%C3%AE-fe-2-o-3-prepared-by-modified-sol-gel-process
#2
Moteb M Alqahtani, Atif M Ali, Farid A Harraz, M Faisal, Adel A Ismail, Mahmoud A Sayed, M S Al-Assiri
Mesoporous α-Fe2 O3 has been synthesized via a simple sol-gel procedure in the presence of Pluronic (F-127) triblock copolymer as structure directing agent. Silver (Ag) nanoparticles were deposited onto α-Fe2 O3 matrix by the photochemical reduction approach. Morphological analysis revealed the formation of Ag nanoparticles with small sizes < 20 nm onto the mesoporous structure of α-Fe2 O3 possessing < 50 nm semi-spherical shape. The XRD, FTIR, Raman, UV-vis, PL, and N2 sorption isotherm studies confirmed the high crystallinity, mesoporosity, and optical characteristics of the synthesized product...
May 21, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29785530/azoospermia-and-embryo-morphokinetics-testicular-sperm-derived-embryos-exhibit-delays-in-early-cell-cycle-events-and-increased-arrest-prior-to-compaction
#3
Nina Desai, Pavinder Gill, Nicholas N Tadros, Jeffrey M Goldberg, Edmund Sabanegh, Tommaso Falcone
PURPOSE: Sperm play an essential role in embryonic genome activation and embryonic progression to blastocyst. In the present work, we focus on development of embryos created as a result of ICSI with testicular or epididymal sperm from azoospermic males and compare this to outcomes from normospermic males. The objective of this study was to determine if sperm origin influences clinical outcomes, the kinetics of embryo development, or the incidence of cleavage anomalies and multinucleation...
May 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29784813/coordination-of-the-leucine-sensing-rag-gtpase-cycle-by-leucyl-trna-synthetase-in-the-mtorc1-signaling-pathway
#4
Minji Lee, Jong Hyun Kim, Ina Yoon, Chulho Lee, Mohammad Fallahi Sichani, Jong Soon Kang, Jeonghyun Kang, Min Guo, Kang Young Lee, Gyoonhee Han, Sunghoon Kim, Jung Min Han
A protein synthesis enzyme, leucyl-tRNA synthetase (LRS), serves as a leucine sensor for the mechanistic target of rapamycin complex 1 (mTORC1), which is a central effector for protein synthesis, metabolism, autophagy, and cell growth. However, its significance in mTORC1 signaling and cancer growth and its functional relationship with other suggested leucine signal mediators are not well-understood. Here we show the kinetics of the Rag GTPase cycle during leucine signaling and that LRS serves as an initiating "ON" switch via GTP hydrolysis of RagD that drives the entire Rag GTPase cycle, whereas Sestrin2 functions as an "OFF" switch by controlling GTP hydrolysis of RagB in the Rag GTPase-mTORC1 axis...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29784144/it-is-important-that-the-process-goes-quickly-isn-t-it-a-qualitative-multi-country-study-of-colorectal-or-lung-cancer-patients-narratives-of-the-timeliness-of-diagnosis-and-quality-of-care
#5
Marlene Malmström, Birgit H Rasmussen, Britt-Marie Bernhardson, Senada Hajdarevic, Lars E Eriksson, Rikke Sand Andersen, John I MacArtney
PURPOSE: The emphasis on early diagnosis to improve cancer survival has been a key factor in the development of cancer pathways across Europe. The aim of this analysis was to explore how the emphasis on early diagnosis and timely treatment is reflected in patient's accounts of care, from the first suspicion of colorectal or lung cancer to their treatment in Denmark, England and Sweden. METHOD: We recruited 155 patients in Denmark, England and Sweden who were within six months of being diagnosed with lung or colorectal cancer...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29783985/the-doses-of-plasmid-backbone-plays-a-major-role-in-determining-the-hbv-clearance-in-hydrodynamic-injection-mouse-model
#6
Xian Wang, Jianmin Zhu, Yong Zhang, Yue Li, Tai Ma, Qun Li, Jiegou Xu, Long Xu
BACKGROUND: Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, causing a major risk of liver disease and hepatocellular carcinoma (HCC). Many mouse models have been tried to establish HBV infection through injection with various HBV-containing plasmids. However, it is not well understood that different plasmids, all of which contain the similar HBV genome, even the same plasmids with different dose, results in opposite immune responses toward HBV. METHODS: In this study, we investigated the role of HBV-containing plasmid backbones and the HBcAg in determining the HBV persistence...
May 21, 2018: Virology Journal
https://www.readbyqxmd.com/read/29782832/nup159-weakens-gle1-binding-to-dbp5-but-does-not-accelerate-adp-release
#7
Emily V Wong, Shawn Gray, Wenxiang Cao, Rachel Montpetit, Ben Montpetit, Enrique M De La Cruz
Dbp5, DDX19 in humans, is an essential DEAD-box protein involved in mRNA export, which has also been linked to other cellular processes, including rRNA export and translation. Dbp5 ATPase activity is regulated by several factors, including RNA, the nucleoporin proteins Nup159 and Gle1, and the endogenous small molecule inositol hexakisphosphate (InsP6 ). To better understand how these factors modulate Dbp5 activity and how this modulation relates to in vivo RNA metabolism, a detailed characterization of the Dbp5 mechanochemical cycle in the presence of those regulators individually or together is necessary...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782677/ultrathin-transition-metal-dichalcogenide-3d-metal-hydroxide-hybridized-nanosheets-to-enhance-hydrogen-evolution-activity
#8
Zhengju Zhu, Huajie Yin, Chun-Ting He, Mohammad Al-Mamun, Porun Liu, Lixue Jiang, Yong Zhao, Yun Wang, Hua-Gui Yang, Zhiyong Tang, Dan Wang, Xiao-Ming Chen, Huijun Zhao
The vast majority of the reported hydrogen evolution reaction (HER) electrocatalysts perform poorly under alkaline conditions due to the sluggish water dissociation kinetics. Herein, a hybridization catalyst construction concept is presented to dramatically enhance the alkaline HER activities of catalysts based on 2D transition metal dichalcogenides (TMDs) (MoS2 and WS2 ). A series of ultrathin 2D-hybrids are synthesized via facile controllable growth of 3d metal (Ni, Co, Fe, Mn) hydroxides on the monolayer 2D-TMD nanosheets...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782172/assembly-dynamics-of-plasmonic-dna-capped-gold-nanoparticle-monolayers
#9
Thomas L Derrien, Michelle Zhang, Patrick Dorion, Detlef-M Smilgies, Dan Luo
The self-assembly of nanoparticles in aqueous solutions promises wide applications but requires the careful balance of many parameters not present in organic solvents. While the presence of long-range electrostatic interactions in aqueous solutions may complicate such assemblies, they provide additional parameters through which to control self-assembly. Here, with DNA-capped gold nanoparticles and through variation of the ionic strength in aqueous solutions, we explored the influence of electrostatic interactions on the adsorption of negatively charged nanoparticles on a positively charged surface...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29781616/cobalt-catalyzed-regioselective-olefin-isomerization-under-kinetic-control
#10
Xufang Liu, Wei Zhang, Yujie Wang, Ze-Xin Zhang, Lei Jiao, Qiang Liu
Olefin isomerization is a significant transformation in organic synthesis, which provides a convenient synthetic route for internal olefins and remote functionalization processes. The selectivity of an olefin isomerization process is often thermodynamically controlled. Thus, to achieve selectivity under kinetic control is very challenging. Herein, we report a novel cobalt-catalyzed regioselective olefin isomerization reaction. By taking the advantage of fine-tunable NNP-pincer ligand structures, this catalytic system features high kinetic control of regioselectivity...
May 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29781539/intermittent-resistance-exercise-and-obesity-considered-separately-or-combined-impair-spermatic-parameters-in-adult-male-wistar-rats
#11
Ana Paula Franco Punhagui, Giovana Rampazzo Teixeira, Marcelo Conrado de Freitas, Patricia Monteiro Seraphim, Glaura Scantamburlo Alves Fernandes
Obesity and absence of physical exercise are global problems that affect concentration and sperm quality in the male reproductive system. The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high-fat diet...
May 21, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29781281/comparison-of-phonon-damping-behavior-in-quantum-dots-capped-with-organic-and-inorganic-ligands
#12
Kyle J Schnitzenbaumer, Gordana Dukovic
Surface ligand modification of colloidal semiconductor nanocrystals has been widely used as a means of controlling photoexcited state generation, relaxation, and coupling to the environment. While progress has been made in understanding how surface ligand modification affects the behavior of excitonic states, less is known about the influence of surface ligand modification on phonon behavior, which impacts relaxation dynamics and transport phenomena. In this work we compare the dynamics of optical and acoustic phonons in CdTe quantum dots (QDs), CdTe/CdSe core/shell QDs capped with octadecylphosphonic acid ligands, and CdTe QDs capped with Se2- to ascertain how ligand exchange from native aliphatic ligands to single-atom Se2- ligands affects phonon behavior...
May 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29781044/sleeve-gastrectomy-in-morbidly-obese-hiv-patients-focus-on-anti-retroviral-treatment-absorption-after-surgery
#13
Chloé Amouyal, Marion Buyse, Lea Lucas-Martini, Déborah Hirt, Laurent Genser, Adriana Torcivia, Jean-Luc Bouillot, Jean-Michel Oppert, Judith Aron-Wisnewsky
CONTEXT: Anti-retroviral therapy (ART) dramatically reduced AIDS development, thus enabling patients to live as long as the general population. New challenges have emerged particularly cardiometabolic diseases and weight gain, with some HIV patients seeking bariatric surgery (BS). However, BS outcomes during HIV remain poorly described, with scarce data on ART pharmacokinetic post-BS. OBJECTIVE: Describing sleeve gastrectomy (SG) results in HIV patients in terms of ART pharmacokinetic, HIV control, weight loss, and metabolic outcomes...
May 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29780993/ideal-reversible-polymer-networks
#14
German Alberto Parada, Xuanhe Zhao
In this article we introduce the concept of ideal reversible polymer networks, which have well-controlled polymer network structures similar to ideal covalent polymer networks but exhibit viscoelastic behaviors due to the presence of reversible crosslinks. We first present a theory to describe the mechanical properties of ideal reversible polymer networks. Because short polymer chains of equal length are used to construct the network, there are no chain entanglements and the chains' Rouse relaxation time is much shorter than the reversible crosslinks' characteristic time...
May 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29780562/kinetic-studies-on-strand-displacement-in-de-novo-designed-parallel-heterodimeric-coiled-coils
#15
Mike C Groth, W Mathis Rink, Nils F Meyer, Franziska Thomas
Among the protein folding motifs, which are accessible by de novo design, the parallel heterodimeric coiled coil is most frequently used in bioinspired applications and chemical biology in general. This is due to the straightforward sequence-to-structure relationships, which it has in common with all coiled-coil motifs, and the heterospecificity, which allows control of association. Whereas much focus was laid on designing orthogonal coiled coils, systematic studies on controlling association, for instance by strand displacement, are rare...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780459/folding-mechanisms-steer-the-amyloid-fibril-formation-propensity-of-highly-homologous-proteins
#16
Gaetano Malgieri, Gianluca D'Abrosca, Luciano Pirone, Angelo Toto, Maddalena Palmieri, Luigi Russo, Michele Francesco Maria Sciacca, Rosarita Tatè, Valeria Sivo, Ilaria Baglivo, Roksana Majewska, Massimo Coletta, Paolo Vincenzo Pedone, Carla Isernia, Mario De Stefano, Stefano Gianni, Emilia Maria Pedone, Danilo Milardi, Roberto Fattorusso
Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways. Here, we fully characterize, by means of stopped-flow, T-jump, CD and DSC experiments, the unfolding mechanisms of three highly homologous proteins, zinc binding Ros87 and Ml153-149 and zinc-lacking Ml452-151 . The results indicate that the three proteins significantly differ in terms of stability and (un)folding mechanisms...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779256/hierarchical-bi2te3-nanostrings-green-synthesis-and-their-thermoelectric-properties
#17
Shuyan Song, Yu Liu, Qishun Wang, Jing Pan, Yabin Sun, Lingling Zhang
Bi2Te3 hierarchical nanostrings have been synthesized through a solvothermal approach with the assistance of sucrose. The hierarchical Bi2Te3 was supposed to be fabricated through a self-assembly process. Te nanorods first emerge with the reduction of TeO32- followed by heterogeneous nucleation of Bi2Te3 nanoplates on the surface and tips of Te nanorods. Te nanorods further transform into Bi2Te3 nanorods simultaneously with the nanoplates' growth leading to a hierarchical structure. Through controlling the reaction kinetics by adding different amount of ethylene glycol, the length of nanorods and the number of nanoplates could be tailored...
May 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29778797/discovery-of-potent-%C3%AE-glucosidase-inhibitor-flavonols-insights-into-mechanism-of-action-through-inhibition-kinetics-and-docking-simulations
#18
Didem Şöhretoğlu, Suat Sari, Burak Barut, Arzu Özel
Beside other pharmaceutical benefits, flavonoids are known for their potent α-glucosidase inhibition. In the present study, we investigated α-glucosidase inhibitory effects of structurally related 11 flavonols, among which quercetin-3-O-(3″-O-galloyl)-β-galactopyranoside (8) and quercetin 3-O-(6″-O-galloyl)-β-glucopyranoside (9) showed significant inhibition compared to the positive control, acarbose, with IC50 values of 0.97 ± 0.02 and 1.35 ± 0.06 µM, respectively. It was found that while sugar substitution to C3-OH of C ring reduced the α-glucosidase inhibitory effect, galloyl substitution to these sugar units increased it...
May 17, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29778676/development-of-an-anion-imprinted-polymer-for-high-and-selective-removal-of-arsenite-from-wastewater
#19
Lili Fang, Xiaoye Min, Renfei Kang, Haiyan Yu, Spyros G Pavlostathis, Xubiao Luo
A novel cyclic functional monomer (CFM) was used to develop an As(III)-ion imprinted polymer (As-IIP). CFM possesses a positively charged imidazolium moiety and its specific cyclic size matches that of As(III). Batch adsorption experiments showed that the As-IIP has a maximum As(III) adsorption capacity of 55 mg/g, while that of the control polymer (CP) is only 25 mg As(III)/g. Adsorption isotherms for As(III) agree with the Langmuir model, suggesting monolayer adsorption. Kinetic studies showed that the adsorption process followed pseudo-second-order kinetics...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778181/live-attenuated-duck-hepatitis-virus-vaccine-in-breeder-ducks-protective-efficacy-and-kinetics-of-maternally-derived-antibodies
#20
Jae-Hee Roh, Min Kang
Duck viral hepatitis type I is a rapidly spreading infection lethal in young ducklings, caused by the duck hepatitis A virus (DHAV). Vaccination of breeder ducks is a common practice to control DHAV. However, maintaining proper maternal antibody levels in large flocks is difficult. Therefore, a simple vaccination strategy that can induces stable high antibody levels through mass vaccination is desirable. We evaluated a DHAV vaccination strategy for breeder ducks involving oral administration under field conditions, and examined the kinetics of antibody response in the ducks and their progeny...
June 2018: Veterinary Microbiology
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