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Female sex hormones

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https://www.readbyqxmd.com/read/29049519/association-of-bone-mineral-density-with-the-risk-of-intracranial-aneurysm
#1
Yong-Won Shin, Kyung-Il Park, Jangsup Moon, Soon-Tae Lee, Kon Chu, Sang Kun Lee, Jae-Kyu Roh, Keun-Hwa Jung
Importance: Disruption of extracellular matrix integrity is critically involved in both intracranial aneurysm and bone fragility. Furthermore, both intracranial aneurysm and osteoporosis have a female predominance, and sex hormones are considered to affect this discrepancy. Objective: To evaluate the association between bone mineral density and intracranial aneurysm. Design, Setting, and Participants: A cross-sectional study conducted with 14 328 patients who underwent brain magnetic resonance angiography and bone mineral densitometry as a part of a health examination at a specialized center for comprehensive health examination in Seoul, the largest metropolitan area in the Republic of Korea, between December 2004 and November 2015...
October 16, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29046359/androgens-trigger-different-growth-responses-in-genetically-identical-human-hair-follicles-in-organ-culture-that-reflect-their-epigenetic-diversity-in-life
#2
Benjamin H Miranda, Matthew R Charlesworth, Desmond J Tobin, David T Sharpe, Valerie A Randall
Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs (e.g., beard). Follicle response is epigenetically varied: some remain unaffected (e.g., eyelashes) or are inhibited, causing balding. How sex steroid hormones alter such developmental processes is unclear, despite high incidences of hormone-driven cancer, hirsutism, and alopecia...
October 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29046315/sex-differences-in-maternal-gestational-hypertension-induced-sensitization-of-angiotensin-ii-hypertension-in-rat-offspring-the-protective-effect-of-estrogen
#3
Baojian Xue, Terry G Beltz, Fang Guo, Alan Kim Johnson
Recent studies demonstrate that maternal hypertension during pregnancy sensitizes an angiotensin (ANG) II-induced increase in blood pressure (BP) in adult male offspring that was associated with upregulation of mRNA expression of several renin-angiotensin-aldosterone system (RAAS) components and NADPH oxidase in the lamina terminalis (LT) and paraventricular nucleus (PVN). The purpose of the present study was to test whether there are sex differences in the maternal hypertension-induced sensitization of ANG II hypertension, and whether sex hormones are involved in the sensitization process...
October 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29044801/differential-physiological-responses-to-central-leptin-overexpression-in-male-and-female-rats
#4
Isabelle Côté, Sara M Green, Hale Z Toklu, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
Brains of females are more sensitive to the acute catabolic actions of leptin. However, sex differences in the long-term physiological responses to central leptin receptor modulation are unknown. To this end, we centrally delivered a viral vector to overexpress leptin (Leptin), a neutral leptin receptor antagonist (Leptin-Antagonist), or a green fluorescence protein (Control). We examined chronic changes in body weight and composition in male and female rats. Females displayed greater and sustained responses to Leptin whereas males rapidly lost physiological effects and developed leptin resistance confirmed by lower acute leptin-mediated phosphorylation of STAT3 (P-STAT3)...
October 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29044430/molecular-regulation-of-sex-change-induced-by-methyltestosterone-feeding-and-methyltestosterone-feeding-withdrawal-in-the-protogynous-orange-spotted-grouper
#5
Qing Wang, Yun Liu, Cheng Peng, Xiang Wang, Ling Xiao, Dengdong Wang, Jiaxing Chen, Haifa Zhang, Huihong Zhao, Shuisheng Li, Yong Zhang, Haoran Lin
The sex identity of fish can be easily manipulated by exogenous hormones. Treatment with 17-methyltestosterone (MT) has been widely used to induce a male fate, but the molecular and cellular processes underlying sex changes induced by MT treatments and the withdrawal of MT are not well studied. In this study, we systematically investigated gonadal histology, gene expression profiles, sex steroid hormone levels, and cellular changes during sex changes induced by MT-feeding and MT-feeding withdrawal in the protogynous orange-spotted grouper, Epinephelus coioides...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29039351/epidemiology-risk-factors-and-prognosis-of-interferon-alpha-induced-thyroid-disorders-a-prospective-clinical-study
#6
Łukasz Obołończyk, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, Anna Lewczuk, Monika Berendt-Obołończyk, Anna Lakomy, Zofia Michalska, Danuta Radowska, Grażyna Moszkowska, Agnieszka Bianek-Bodzak, Krzysztof Sworczak
INTRODUCTION: Hepatitis C virus (HCV) infection is a worldwide problem and hepatitis, which is its natural unfavourable course, is still a challenge for hepatologist. At present, standards of treatment are changing from combined therapy with interferon alpha (IFN-α) and ribavirin to new antiviral drugs. The current classification divides interferon induced thyroid diseases (IITD) into two groups: autoimmune (Hashimoto disease, Graves disease, positive antithyroid autoantibodies in euthyroid patients) and non-autoimmune (destructive thyroiditis, non-autoimmune hypothyroidism)...
September 25, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29037971/to-fight-or-mate-hormonal-control-of-sex-recognition-male-sexual-behavior-and-aggression-in-the-gecko-lizard
#7
Tereza Schořálková, Lukáš Kratochvíl, Lukáš Kubička
Squamate reptiles are a highly diversified vertebrate group with extensive variability in social behavior and sexual dimorphism. However, hormonal control of these traits has not previously been investigated in sufficient depth in many squamate lineages. Here, we studied the hormonal control of male sexual behavior, aggressiveness, copulatory organ (hemipenis) size and sex recognition in the gecko Paroedura picta, comparing ovariectomized females, ovariectomized females treated with exogenous dihydrotestosterone (DHT), ovariectomized females treated with exogenous testosterone (T), control females and males...
October 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29033921/influence-of-oral-and-gut-microbiota-in-the-health-of-menopausal-women
#8
REVIEW
Angélica T Vieira, Paula M Castelo, Daniel A Ribeiro, Caroline M Ferreira
Sex differences in gut microbiota are acknowledged, and evidence suggests that gut microbiota may have a role in higher incidence and/or severity of autoimmune diseases in females. Additionally, it has been suggested that oral, vaginal, and gut microbiota composition can be regulated by estrogen levels. The association of vaginal microbiota with vulvovaginal atrophy at menopause is well described in the literature. However, the relevance of oral and gut microbiota modulation in the immune system during estrogen deficiency and its effect on inflammatory diseases is not well explored...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033879/nasally-administered-oxytocin-has-limited-effects-on-owner-directed-attachment-behavior-in-pet-dogs-canis-lupus-familiaris
#9
Lauren E Thielke, Giovanna Rosenlicht, Sarina R Saturn, Monique A R Udell
The present study explored the effects of intranasal oxytocin, a naturally occurring hormone, on the behavior of pet dogs during an attachment test. Each dog participated in two testing sessions. On one visit saline was administered nasally, and on another, oxytocin was administered nasally. For half of the dogs (n = 20), solutions were administered with a Mucosal Atomization Device (MAD) and for half of the dogs (n = 20), solutions were administered using a nasal spray bottle. Condition order was counterbalanced and a double-blind methodology was employed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29032323/neural-activity-during-traumatic-film-viewing-is-linked-to-endogenous-estradiol-and-hormonal-contraception
#10
Stephan F Miedl, Melanie Wegerer, Hubert Kerschbaum, Jens Blechert, Frank H Wilhelm
Women are at higher risk for Posttraumatic Stress Disorder (PTSD) and recent research has highlighted a modulating role of female sex hormones for cognitive and emotional processes potentially underlying PTSD symptoms. However, studies combining fMRI recordings of brain activity during trauma film viewing with assessment of female sex hormones are missing. The trauma film paradigm - a widely used experimental analogue for trauma exposure - confronts healthy participants with traumatic film clips and thus allows studying peritraumatic processing under laboratory conditions...
October 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29031189/renal-subcapsular-xenografing-of-human-fetal-external-genital-tissue-a-new-model-for-investigating-urethral-development
#11
Dylan Isaacson, Joel Shen, Mei Cao, Adriane Sinclair, Xuan Yue, Gerald Cunha, Laurence Baskin
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized athymic mice. The mice were treated with a subcutaneous pellet of dihydrotestosterone (DHT), diethylstilbestrol (DES) or untreated with hormones. Xenografts were harvested after fourteen days of growth and analyzed via serial histologic sectioning and immunostaining for Ki-67, cytokeratins 6, 7 and 10, uroplakin and the androgen receptor...
September 22, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29030490/early-sex-dependent-differences-in-response-to-environmental-stress
#12
Serafin Pérez-Cerezales, Priscila Ramos-Ibeas, Dimitrios Rizos, Pat Lonergan, Pablo Bermejo-Alvarez, Alfonso Gutierrez-Adan
Developmental plasticity enables the appearance of long-term effects in offspring caused by exposure to environmental stressors during embryonic and foetal life. These long-term effects can be traced to pre- and post-implantation development, and in both cases the effects are usually sex-specific. During preimplantation development, male and female embryos exhibit an extensive transcriptional dimorphism mainly driven by incomplete X-chromosome inactivation. These early developmental stages are crucial for the establishment of epigenetic marks that will be conserved throughout development, making it a particularly susceptible period for the appearance of long-term epigenetic-based phenotypes...
October 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29029883/brain-sexual-differentiation-and-effects-of-cross-sex-hormone-therapy-in-transpeople-a-resting-state-functional-magnetic-resonance-study
#13
Nienke M Nota, Sarah M Burke, Martin den Heijer, Remi S Soleman, Cornelis B Lambalk, Peggy T Cohen-Kettenis, Dick J Veltman, Baudewijntje P Kreukels
OBJECTIVES: It is hypothesized that transpeople show sex-atypical differentiation of the brain. Various structural neuroimaging studies provide support for this notion, but little is known about the sexual differentiation of functional resting-state networks in transpeople. In this study we therefore aimed to determine whether brain functional connectivity (FC) patterns in transpeople are sex-typical or sex-atypical, before and after the start of cross-sex hormone therapy (CHT). METHODS: We acquired resting-state functional magnetic resonance data in 36 transpeople (22 with female sex assigned at birth), first during gonadal suppression, and again four months after start of CHT, and in 37 cisgender people (20 females), both sessions without any hormonal intervention...
October 10, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29027807/annals-express-biochemistry-of-the-menopause
#14
John W Honour
The life of a human female is characterised from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the peri-menopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027649/sex-specific-effects-of-combined-exposure-to-chemical-and-non-chemical-stressors-on-neuroendocrine-development-a-review-of-recent-findings-and-putative-mechanisms
#15
REVIEW
Whitney J Cowell, Rosalind J Wright
PURPOSE OF REVIEW: Environmental toxicants and psychosocial stressors share many biological substrates and influence overlapping physiological pathways. Increasing evidence indicates stress-induced changes to the maternal milieu may prime rapidly developing physiological systems for disruption by concurrent or subsequent exposure to environmental chemicals. In this review, we highlight putative mechanisms underlying sex-specific susceptibility of the developing neuroendocrine system to the joint effects of stress or stress correlates and environmental toxicants (bisphenol A, alcohol, phthalates, lead, chlorpyrifos, and traffic-related air pollution)...
October 13, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29025054/presence-of-polycystic-ovary-syndrome-is-associated-with-longer-anogenital-distance-in-adult-mediterranean-women
#16
María L Sánchez-Ferrer, Jaime Mendiola, Ana I Hernández-Peñalver, Shiana Corbalán-Biyang, Ana Carmona-Barnosi, María T Prieto-Sánchez, Aníbal Nieto, Alberto M Torres-Cantero
STUDY QUESTION: Is polycystic ovary syndrome (PCOS) associated with anogenital distance (AGD), a biomarker of fetal androgen exposure, in adult Mediterranean women? SUMMARY ANSWER: Longer AGD is associated with PCOS in adult Mediterranean women. WHAT IS KNOWN ALREADY: AGD is a biomarker of prenatal androgen milieu. Human observational studies have reported that associations between AGD and reproductive parameters in both sexes. Exposure of the female fetus to intrauterine androgens may be a risk factor for PCOS in adulthood...
August 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29020200/the-effect-of-female-sex-on-hepatitis-c-incidence-among-people-who-inject-drugs-results-from-the-international-multi-cohort-inc3-collaborative
#17
Aryan Esmaeili, Ali Mirzazadeh, Meghan D Morris, Behzad Hajarizadeh, Henry S Sacks, Lisa Maher, Jason Grebely, Arthur Y Kim, Georg Lauer, Andrea L Cox, Margaret Hellard, Paul Dietze, Julie Bruneau, Naglaa H Shoukry, Gregory J Dore, Andrew R Lloyd, Maria Prins, Kimberly Page
Background: The objective of this study was to assess differences in hepatitis C virus (HCV) incidence by sex in people who inject drugs (PWID), using a large international multi-cohort set of pooled biological and behavioral data from prospective observational studies of incident HIV and HCV infections in high-risk cohorts (the InC3 Collaborative). Methods: HCV infection date was estimated based on a hierarchy of successive serological (anti-HCV), virological (HCV RNA) and clinical (symptoms and/or liver function tests) data...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019819/a-research-of-pyogenic-granuloma-genesis-factor-with-immunohistochemical-analysis
#18
Si Hyun Park, Jun Ho Lee, Min Sung Tak, Hyun Ju Lee, Hwan Jun Choi
Pyogenic granuloma (PG) is a type of vascular tumor for which the growth mechanism is poorly understood. Estrogen and progesterone may influence vascular malformations by increasing neovascularization in the lesions. Pregnancy tumor is a term for PG that occurs on the gingival mucosa of pregnant women in response to local irritation or injury. The etiology and pathogenesis of this phenomenon are not fully understood. Hormonal imbalance has been hypothesized to be responsible for the development of gingival hyper-reactive inflammatory responses...
October 10, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29016690/expression-profile-of-amh-amh-during-bi-directional-sex-change-in-the-protogynous-orange-spotted-grouper-epinephelus-coioides
#19
Guan-Chung Wu, Hau-Wen Li, Wei-Guan Tey, Chien-Ju Lin, Ching-Fong Chang
Gonadal differentiation is tightly regulated by the initial sex determining gene and the downstream sex-related genes in vertebrates. However, sex change in fish can alter the sexual fate from one sex to the other. Chemical-induced maleness in the protogynous orange-spotted grouper is transient, and a reversible sex change occurs after the chemical treatment is withdrawn. We used these characteristics to study Amh signaling during bi-directional sex change in the grouper. We successfully induced the female-to-male sex change by chemical (aromatase inhibitor, AI, or methyltestosterone, MT) treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28993643/a-sexually-dimorphic-pre-stressed-translational-signature-in-ca3-pyramidal-neurons-of-bdnf-val66met-mice
#20
Jordan Marrocco, Gordon H Petty, Mariel B Ríos, Jason D Gray, Joshua F Kogan, Elizabeth M Waters, Eric F Schmidt, Francis S Lee, Bruce S McEwen
Males and females use distinct brain circuits to cope with similar challenges. Using RNA sequencing of ribosome-bound mRNA from hippocampal CA3 neurons, we found remarkable sex differences and discovered that female mice displayed greater gene expression activation after acute stress than males. Stress-sensitive BDNF Val66Met mice of both sexes show a pre-stressed translational phenotype in which the same genes that are activated without applied stress are also induced in wild-type mice by an acute stressor...
October 9, 2017: Nature Communications
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