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https://www.readbyqxmd.com/read/29667557/modification-of-sexual-hormones-in-rheumatoid-arthritis-patients-by-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-nsaid-with-immunosuppressive-property
#1
Mozhgan Jahanbakhshi, Zohreh Babaloo, Seyed Shahabeddin Mortazavi-Jahromi, Maryam Monsef Shokri, Hossein Ahmadi, Abbas Mirshafiey
BACKGROUND: Based on in-vitro, in-vivo and human studies, the β-D-mannuronic acid (M2000) has been introduced as a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive properties. OBJECTIVE: This study aimed to evaluate the efficacy of this drug on serum level of sex hormones (Estradiol, Progesterone, and DHEAS) in rheumatoid arthritis (RA) patients. METHODS: The present research was performed on 10 RA patients who had an inadequate response to conventional treatments (clinical trial identifier: IRCT2014011213739N2)...
April 17, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29666640/investigating-the-interactive-effects-of-sex-steroid-hormones-and-brain-derived-neurotrophic-factor-during-adolescence-on-hippocampal-nmda-receptor-expression
#2
Cushla R McCarthny, Xin Du, YeeWen Candace Wu, Rachel A Hill
Sex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/- ) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectomised, and females received either 17 β -estradiol or progesterone treatment, while males received either testosterone or dihydrotestosterone (DHT) treatment. Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot analysis...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29666308/estrogen-receptor-%C3%AE-contributes-to-t-cell-mediated-autoimmune-inflammation-by-promoting-t-cell-activation-and-proliferation
#3
Imran Mohammad, Inna Starskaia, Tamas Nagy, Jitao Guo, Emrah Yatkin, Kalervo Väänänen, Wendy T Watford, Zhi Chen
It has long been appreciated that most autoimmune disorders are characterized by increased prevalence in females, suggesting a potential role for sex hormones in the etiology of autoimmunity. To study how estrogen receptor α (ERα) contributes to autoimmune diseases, we generated mice in which ERα was deleted specifically in T lymphocytes. We found that ERα deletion in T cells reduced their pathogenic potential in a mouse model of colitis and correlated with transcriptomic changes that affected T cell activation...
April 17, 2018: Science Signaling
https://www.readbyqxmd.com/read/29663559/sex-differences-in-hippocampal-mineralocorticoid-and-glucocorticoid-receptor-mrna-expression-in-response-to-acute-mate-pair-separation-in-zebra-finches-taeniopygia-guttata
#4
Farrah N Madison, Andrew J Kesner, Beau A Alward, Gregory F Ball
Mate separation has been shown to mediate changes in physiological and behavioral processes via activation of the hypothalamo-pituitary-adrenal (HPA) axis in both mammalian and avian species. In order to elucidate the neural mechanisms associated with changes in the HPA axis in response to social stress, we investigated the effects of mate pair separation on circulating corticosterone concentrations as well as gene expression levels of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), and corticotropin releasing hormone (CRH) in the hypothalamus and hippocampus of both male and female zebra finches, a species that forms strong pair bonds...
April 16, 2018: Hippocampus
https://www.readbyqxmd.com/read/29662964/comparison-of-the-effects-of-ginger-extract-with-clomiphene-citrate-on-sex-hormones-in-rats-with-polycystic-ovarian-syndrome
#5
Shekoufeh Atashpour, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Mozhgan Maleknasab
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women which affect fertility. Clomiphene citrate is used as first-line treatment for this disorder, which is associated with some complications and therapeutic resistance. Objective: In this research, we compare the effectiveness of ginger with clomiphene on sexual hormones such as Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), estrogen and progesterone in order to treat PCOS effectively with fewer side effects...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29662485/our-environment-shapes-us-the-importance-of-environment-and-sex-differences-in-regulation-of-autoantibody-production
#6
REVIEW
Michael Edwards, Rujuan Dai, S Ansar Ahmed
Consequential differences exist between the male and female immune systems' ability to respond to pathogens, environmental insults or self-antigens, and subsequent effects on immunoregulation. In general, females when compared with their male counterparts, respond to pathogenic stimuli and vaccines more robustly, with heightened production of antibodies, pro-inflammatory cytokines, and chemokines. While the precise reasons for sex differences in immune response to different stimuli are not yet well understood, females are more resistant to infectious diseases and much more likely to develop autoimmune diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29661439/frequency-of-thyroid-dysfunction-in-patients-with-diabetes-mellitus-before-and-after-liver-transplantation
#7
A Moura Neto, T G Bovi, C M Righetto, A R Fiore, L T Lot, S R Perales, E C de Ataide, I F S F Boin
BACKGROUND: There is mutual influence between the liver and thyroid hormone metabolism. Patients with diabetes mellitus (DM) also have an increased prevalence of thyroid disorders (TDs). The objectives of this study were to evaluate the frequency of TD before and after liver transplantation (LT) in a population of patients with DM as a whole and when categorized by sex. MATERIALS AND METHODS: This was a retrospective study involving interview and medical record analysis of 46 consecutive patients followed at the diabetes mellitus and liver transplantation unit of a tertiary university hospital...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29659830/genome-wide-association-study-identifies-nine-novel-loci-for-2d-4d-finger-ratio-a-putative-retrospective-biomarker-of-testosterone-exposure-in-utero
#8
Nicole M Warrington, Enisa Shevroja, Gibran Hemani, Pirro G Hysi, Yunxuan Jiang, Adam Auton, Cindy G Boer, Massimo Mangino, Carol A Wang, John P Kemp, George McMahon, Carolina Medina-Gomez, Martha Hickey, Katerina Trajanoska, Dieter Wolke, Arfan M Ikram, Grant W Montgomery, Janine F Felix, Margaret J Wright, David A Mackey, Vincent W Jaddoe, Nicholas G Martin, Joyce Y Tung, George Davey Smith, Craig E Pennell, Tim D Spector, Joyce van Meurs, Fernando Rivadeneira, Sarah E Medland, David M Evans
The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a noninvasive biomarker of prenatal androgen exposure. Most association studies of 2D:4D ratio with a diverse range of sex-specific traits have typically involved small sample sizes and have been difficult to replicate, raising questions around the utility and precise meaning of the measure. In the largest genome-wide association meta-analysis of 2D:4D ratio to date (N = 15,661, with replication N = 75,821), we identified eleven loci (nine novel) explaining 3...
April 12, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29657818/developmental-plasticity-of-the-stress-response-in-female-but-not-in-male-guppies
#9
L Chouinard-Thuly, A R Reddon, I Leris, R L Earley, S M Reader
To survive, animals must respond appropriately to stress. Stress responses are costly, so early-life experiences with potential stressors could adaptively tailor adult stress responses to local conditions. However, how multiple stressors influence the development of the stress response remains unclear, as is the role of sex. Trinidadian guppies ( Poecilia reticulata ) are small fish with extensive life-history differences between the sexes and population variation in predation pressure and social density. We investigated how sex and early-life experience influence hormonal stress responses by manipulating conspecific density and perceived predation risk during development...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29655816/sex-specific-transcription-and-dna-methylation-profiles-of-reproductive-and-epigenetic-associated-genes-in-the-gonads-and-livers-of-breeding-zebrafish
#10
L V Laing, J Viana, E Dempster, T M Uren Webster, R van Aerle, J Mill, E M Santos
Reproduction is an essential process for life and is regulated by complex hormone networks and environmental factors. To date, little is known about the contribution of epigenetic mechanisms to the regulation of reproduction, particularly in lower vertebrates. We used the zebrafish (Danio rerio) model to investigate the sex-specific transcription and DNA methylation profiles for genes involved in the regulation of reproduction and in epigenetic signalling in the livers and gonads. We found evidence for associations between DNA promotor methylation and transcription for esr1 (gonads and female livers), amh (gonads) and dnmt1 (livers)...
April 12, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29653158/mice-deficient-in-akap13-brx-develop-compulsive-like-behavior-and-increased-body-weight
#11
K Maravet Baig, Szu-Chi Su, Sunni L Mumford, Emma Giuliani, Sinnie Sin Man Ng, Charles Armstrong, Margaret F Keil, Kamaria Cayton Vaught, Nils Olsen, Elyse Pettiford, Irina Burd, James H Segars
OBJECTIVE: Hormonal contributions to the sex-dependent development of both obsessive-compulsive disorder (OCD) and obesity have been described, but the underlying mechanisms are incompletely understood. A-kinase anchoring protein 13 (AKAP13) significantly augments ligand-dependent activation of estrogen receptors alpha and beta. The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression. The AKAP13 localization pattern observed in these key brain regions together with its effects on sex steroid action suggest a potential role for AKAP13 in compulsive-like behaviors...
April 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29648485/biochemical-hematological-and-hormonal-profile-of-rats-orally-administered-methanol-stem-bark-extract-of-napoleona-vogelii-hook-and-planch-lecythidaceae
#12
Victor Olabowale Ikumawoyi, Esther Oluwatoyin Agbaje, Olufunsho Awodele, Akinwumi Akinyinka Akinyede
Napoleona vogelii is used in traditional medicine for the management of stomach aches, ulcer, and cancers. This study was conducted to investigate the subchronic toxicological effect of methanol stem bark extract of N. vogelii on biochemical, hematological, and hormonal profile of male and female rats. Forty rats of both sexes were randomly divided into four groups of 10 rats each and were administered 100, 200, and 400 mg/kg of the extract p.o. for 90 d. Ten milliliter per kilogram of distilled water p...
April 12, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29643836/tau-phosphorylation-in-female-neurodegeneration-role-of-estrogens-progesterone-and-prolactin
#13
REVIEW
Daniel Muñoz-Mayorga, Christian Guerra-Araiza, Luz Torner, Teresa Morales
Sex differences are important to consider when studying different psychiatric, neurodevelopmental, and neurodegenerative disorders, including Alzheimer's disease (AD). These disorders can be affected by dimorphic changes in the central nervous system and be influenced by sex-specific hormones and neuroactive steroids. In fact, AD is more prevalent in women than in men. One of the main characteristics of AD is the formation of neurofibrillary tangles, composed of the phosphoprotein Tau, and neuronal loss in specific brain regions...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29642917/gender-specific-association-of-serum-uric-acid-levels-and-cardio-ankle-vascular-index-in-chinese-adults
#14
Xiaoya Zheng, Qiang Wei, Jian Long, Lilin Gong, Hua Chen, Rong Luo, Wei Ren, Yonghong Wang
BACKGROUND: Little is known about the relationship between serum uric acid (SUA) and cardio-ankle vascular index (CAVI) in Chinese population. Therefore, we aimed to investigate the gender difference in the association of SUA and CAVI in a southwestern Chinese population. METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014 in Chongqing. The data included completed anthropometry and blood biochemical indicators...
April 11, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29626485/rapid-effects-of-ovarian-hormones-in-dorsal-striatum-and-nucleus-accumbens
#15
REVIEW
Katie E Yoest, Jacqueline A Quigley, Jill B Becker
Estradiol and progesterone rapidly induce changes in dopaminergic signaling within the dorsal striatum and nucleus accumbens of female rats. In ovariectomized females, estradiol rapidly enhances dopamine release and modulates binding of dopamine receptors. Progesterone further potentiates the effect of estradiol on dopamine release. The effects of both estradiol and progesterone are time course dependent, with increases in dopamine release immediately after acute hormone administration followed by later inhibition of dopamine release...
April 4, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29626450/female-specific-association-between-variants-on-chromosome-9-and-self-reported-diagnosis-of-irritable-bowel-syndrome
#16
Ferdinando Bonfiglio, Tenghao Zheng, Koldo Garcia-Etxebarria, Fatemeh Hadizadeh, Luis Bujanda, Francesca Bresso, Lars Agreus, Anna Andreasson, Aldona Dlugosz, Greger Lindberg, Peter T Schmidt, Pontus Karling, Bodil Ohlsson, Magnus Simren, Susanna Walter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Piero Portincasa, Massimo Bellini, Giovanni Barbara, Anna Latiano, Matthias Hübenthal, Vincent Thijs, Mihai G Netea, Daisy Jonkers, Lin Chang, Emeran A Mayer, Mira M Wouters, Guy Boeckxstaens, Michael Camilleri, Andre Franke, Alexandra Zhernakova, Mauro D'Amato
BACKGROUND & AIMS: Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based cohort, which includes genotype and health data from 500,000 participants. METHODS: We studied 7,287,191 high-quality single-nucleotide polymorphisms in individuals who self-reported a doctor's diagnosis of IBS (cases; m=9576) compared to the remainder of the cohort (controls; n=336,499) (mean age of study subjects, 40-69 years)...
April 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29621723/persistent-organic-pollutants-as-predictors-of-increased-fsh-lh-ratio-in-naturally-cycling-reproductive-age-women
#17
Mia V Gallo, Julia Ravenscroft, David O Carpenter, Lawrence M Schell, Akwesasne Task Force On The Environment
Although several recent studies suggest endocrine disrupting compounds, such as polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p', DDE), and hexachlorobenzene (HCB), target different organs and systems in the body, their impact on female reproductive function in humans is not well characterized. We seek to determine the relationship between several known endocrine disrupting compounds and a marker of ovarian responsivity, the FSH:LH ratio (higher ratio indicates less ovarian responsivity)...
April 2, 2018: Environmental Research
https://www.readbyqxmd.com/read/29621673/part-b-morphometric-and-transcriptomic-responses-to-sub-chronic-exposure-to-the-polycyclic-aromatic-hydrocarbon-phenanthrene-in-the-fathead-minnow-pimephales-promelas
#18
Jennifer R Loughery, Karen A Kidd, Angella Mercer, Chris J Martyniuk
Phenanthrene is a tricyclic polycyclic aromatic hydrocarbon and environmental contaminant found in high concentrations around urban catchments and in the vicinity of oil extraction activities. Fish exposed to phenanthrene can exhibit altered reproductive hormone profiles and/or differences within gonadosomatic index and altered gamete proportions, but the mechanisms underlying these changes are not fully understood. In this study, we conducted a sub-chronic bioassay and measured transcriptional responses in the liver, the major tissue involved in generating lipids for oocyte growth...
March 23, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29618342/metabolic-syndrome-and-body-shape-predict-differences-in-health-parameters-in-farm-working-women
#19
Ilze Mentoor, Maritza Kruger, Theo Nell
BACKGROUND: Sufficient evidence associate body shape to detrimental lifestyle diseases including the metabolic syndrome (MetS). The prevalence of the MetS, as well as effects of the MetS and body shape on body composition, insulin-like growth factor-1 (IGF-1), C-reactive protein (CRP) and sex hormone parameters were investigated in a female farm worker population in the Western Cape. METHODS: Women between the ages of 20-60 years were classified according to the International Diabetes Federation's definition of the MetS...
April 4, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29617359/sexual-dimorphism-of-sleep-regulated-by-juvenile-hormone-signaling-in-drosophila
#20
Binbin Wu, Lingling Ma, Enyan Zhang, Juan Du, Suning Liu, Jeffrey Price, Sheng Li, Zhangwu Zhao
Sexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- and short-sleep phenotypes, respectively. However, the mechanism is still a mystery. In this study, we showed that juvenile hormone (JH) is involved in regulation of sexually dimorphic sleep in Drosophila, in which gain of JH function enlarges differences of the dimorphic sleep phenotype with higher sleep in males and lower sleep in females, while loss of JH function blurs these differences and results in feminization of male sleep and masculinization of female sleep...
April 4, 2018: PLoS Genetics
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