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Polarized macrophages

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https://www.readbyqxmd.com/read/29667418/granulatosides-d-e-and-other-polar-steroid-compounds-from-the-starfish-choriaster-granulatus-their-immunomodulatory-activity-and-cytotoxicity
#1
Natalia V Ivanchina, Alla A Kicha, Timofey V Malyarenko, Sofiya D Ermolaeva, Ekaterina A Yurchenko, Evgeny A Pislyagin, Chau Van Minh, Pavel S Dmitrenok
Two new steroid glycosides, granulatosides D (1) and E (2), belonging to the group of bi- and monoglycosides of polyhydroxysteroids, respectively, were isolated from the ethanolic extract of the starfish Choriaster granulatus along with thirteen previously known glycosides of polyhydroxysteroids (3-15) and one steroid heptaol (16). The structures of the new compounds were elucidated by extensive NMR and ESIMS techniques. Cytotoxic and immunomodulatory activities of compounds 1, 3-8, and 10-16 using murine splenocytes and peritoneal macrophages were studied...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29666270/mk2-contributes-to-tumor-progression-by-promoting-m2-macrophage-polarization-and-tumor-angiogenesis
#2
Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A Merrick, Yuliana Hernandez, Kevin M Haigis, Michael B Yaffe
Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammation and to prevent colorectal tumorigenesis in a mouse model of inflammation-driven colorectal cancer, by mechanisms that are still unclear. Here, using whole-animal and tissue-specific MK2 KO mice, we show that MK2 activity in the myeloid compartment promotes tumor progression by supporting tumor neoangiogenesis in vivo...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666185/hepatocyte-nuclear-receptor-shp-suppresses-inflammation-and-fibrosis-in-a-mouse-model-of-nonalcoholic-steatohepatitis
#3
An Zou, Nancy Magee, Fengyan Deng, Sarah Lehn, Cuncong Zhong, Yuxia Zhang
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide, ranging from nonalcoholic fatty liver (NAFL, steatosis without hepatocellular injury) to the more aggressive nonalcoholic steatohepatitis (NASH, steatosis with ballooning, inflammation, or fibrosis). Although many studies have greatly contributed to the elucidation of NAFLD pathogenesis, the disease progression from NAFL to NASH still remains incompletely understood. Nuclear receptor small heterodimer partner (Nr0b2, SHP) is a transcriptional regulator critical for the regulation of bile acid, glucose, and lipid metabolism...
April 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29666049/m1-and-m2-macrophages-differentially-regulate-hematopoietic-stem-cell-self-renewal-and-ex-vivo-expansion
#4
Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y Lucy Liu, Michele H Cottler-Fox, Peter D Emanuel, Martin Hauer-Jensen, Irwin D Bernstein, Lingbo Liu, Xing Chen, Jianfeng Zhou, Peter J Murray, Daohong Zhou
Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to the development of new strategies for promoting ex vivo HSC expansion. Here, we report the discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, but classical (M1)-polarized macrophages (M1-MΦs) inhibit, the self-renewal and expansion of HSCs from mouse bone marrow (BM) in vitro. The opposite effects of M1-MΦs and M2-MΦs on mouse BM HSCs were attributed to their differential expression of nitric oxide synthase 2 (NOS2) and arginase 1 (Arg1), because genetic knockout of Nos2 and Arg1 or inhibition of these enzymes with a specific inhibitor abrogated the differential effects of M1-MΦs and M2-MΦs...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29662760/macrophages-and-bone-inflammation
#5
REVIEW
Qiaoli Gu, Huilin Yang, Qin Shi
Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle-induced osteolysis. These pathological conditions are associated with inflammatory responses, suggesting the contribution of inflammation to bone destruction. Macrophages are heterogeneous immune cells and are polarized into the proinflammatory M1 and antiinflammatory M2 phenotypes in different microenvironments. The cytokines produced by macrophages depend on the macrophage activation and polarization...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661827/oral-nahco-3-activates-a-splenic-anti-inflammatory-pathway-evidence-that-cholinergic-signals-are-transmitted-via-mesothelial-cells
#6
Sarah C Ray, Babak Baban, Matthew A Tucker, Alec J Seaton, Kyu Chul Chang, Elinor C Mannon, Jingping Sun, Bansari Patel, Katie Wilson, Jacqueline B Musall, Hiram Ocasio, Debra Irsik, Jessica A Filosa, Jennifer C Sullivan, Brendan Marshall, Ryan A Harris, Paul M O'Connor
We tested the hypothesis that oral NaHCO3 intake stimulates splenic anti-inflammatory pathways. Following oral NaHCO3 loading, macrophage polarization was shifted from predominantly M1 (inflammatory) to M2 (regulatory) phenotypes, and FOXP3+ CD4+ T-lymphocytes increased in the spleen, blood, and kidneys of rats. Similar anti-inflammatory changes in macrophage polarization were observed in the blood of human subjects following NaHCO3 ingestion. Surprisingly, we found that gentle manipulation to visualize the spleen at midline during surgical laparotomy (sham splenectomy) was sufficient to abolish the response in rats and resulted in hypertrophy/hyperplasia of the capsular mesothelial cells...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29660515/aspergillus-fumigatus-viability-drives-allergic-responses-to-inhaled-conidia
#7
Ajay P Nayak, Tara L Croston, Angela R Lemons, W T Goldsmith, Nikki B Marshall, Michael L Kashon, Dori R Germolec, Donald H Beezhold, Brett J Green
BACKGROUND: Aspergillus fumigatus induced allergic airway disease has been shown to involve conidial germination in vivo but the immunological mechanisms remain uncharacterized. OBJECTIVE: A subchronic murine exposure model was used to examine the immunological mediators that are regulated in response to either culturable or non-culturable A. fumigatus conidia. METHODS: Female B6C3F1/N mice were repeatedly dosed via inhalation with 1 x 105 viable or heat inactivated conidia (HIC), twice a week for 13 weeks (26 exposures)...
April 13, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29658608/ipsc%C3%A2-msc-inhibition-assessment-in-raw-264-7-cells-following-oxygen-and-glucose-deprivation-reveals-a-distinct-function-for-cardiopulmonary-resuscitation
#8
Yi Yu, Dongping Wang, Hui Li, Yujie Liu, Zhao Xiang, Junlin Wu, Xiaoli Jing
Hypoxia is a serious stress state. The nervous system is less tolerant to hypoxia, and cell death due to hypoxia is irreversible. With the incidence of cardiovascular disease gradually increasing, the sudden cardiac death rate is additionally increasing. Although cardiopulmonary resuscitation (CPR) is an important development, recovery is frequently poor. In a successful recovery population, ~40% of the population was in a vegetative state or subsequently succumbed to their condition, and ~20% had brain damage...
April 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29658082/effect-of-oxidized-dextran-on-cytokine-production-and-activation-of-irf3-transcription-factor-in-macrophages-from-mice-of-opposite-strains-with-different-sensitivity-to-tuberculosis-infection
#9
A V Chechushkov, P M Kozhin, N S Zaitseva, P I Gainutdinov, E B Men'shchikova, A V Troitskii, V A Shkurupy
We studied differences in the production of pro- and anti-inflammatory cytokines and IRF3 transcription factor by peritoneal macrophages from mice of opposite strains CBA/J and C57Bl/6 and the effect of 60-kDa oxidized dextran on these parameters. Macrophages from C57Bl/6 mice were mainly characterized by the production of proinflammatory cytokines TNFα, IL-12, and MCP-1 (markers of M1 polarization). By contrast, CBA/J mice exhibited a relatively high level of anti-inflammatory cytokine IL-10 and lower expression of proinflammatory cytokines (M2 phenotype)...
April 16, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29657156/effects-of-titanium-surface-roughness-on-the-mediation-of-osteogenesis-via-modulating-the-immune-response-of-macrophages
#10
XueZhong Li, Qianli Huang, Tarek A Elkhooly, Yong Liu, Hong Wu, Qingling Feng, Ling Liu, Yu Fang, Weihong Zhu, Tianrui Hu
Osteoblastic lineage cells are commonly used to evaluate the in vitro osteogenic ability of bone biomaterials. However, contradictory results obtained from in vivo and in vitro studies are not uncommon. With the increasing understanding on osteoimmunology, the immune response has been recognized to play an important role in bone regeneration. In this study, we examined the effect of submicron-scaled titanium surface roughness (ranging approximately from 100 to 400 nm) on the response of osteoblasts and macrophages...
April 16, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29656902/legumain-an-asparaginyl-endopeptidase-mediates-the-effect-of-m2-macrophages-on-attenuating-renal-interstitial-fibrosis-in-obstructive-nephropathy
#11
Dekun Wang, Min Xiong, Chuan'ai Chen, Lingfang Du, Ze Liu, Yuzhi Shi, Mianzhi Zhang, Junbo Gong, Xiangrong Song, Rong Xiang, Ergang Liu, Xiaoyue Tan
Two distinct macrophage phenotypes contribute to kidney injury and repair during the progression of renal interstitial fibrosis; proinflammatory (M1) and antiinflammatory (M2) macrophages. Legumain, an asparaginyl endopeptidase of the cysteine protease family, is overexpressed in macrophages in some pathological conditions. However, the macrophage subtype and function of macrophage-derived legumain remains unclear. To resolve this we tested whether M2 macrophages contribute to the accumulation of legumain in the unilateral ureteral obstruction model...
April 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29656208/akt-mtor-and-nf-%C3%AE%C2%BAb-pathway-activation-in-treponema-pallidum-stimulates-m1-macrophages
#12
Li-Rong Lin, Zheng-Xiang Gao, Yong Lin, Xiao-Zhen Zhu, Wei Liu, Dan Liu, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Li-Li Liu, Yao Xiao, Jian-Jun Niu, Fan Liu, Tian-Ci Yang
The polarization of macrophages and the molecular mechanism involved during the early process of syphilis infection remain unknown. This study was conducted to explore the influence of Treponema pallidum (T. pallidum) treatment on macrophage polarization and the Akt-mTOR-NFκB signaling pathway mechanism involved in this process. M0 macrophages derived from the phorbol-12-myristate-13-acetate-induced human acute monocytic leukemia cell line THP-1 were cultured with T. pallidum. T. pallidum induced inflammatory cytokine (IL-1β and TNF-α) expression in a dose- and time-dependent manner...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29656182/co-culture-of-ovarian-cancer-stem-like-cells-with-macrophages-induced-skov3-cells-stemness-via-il-8-stat3-signaling
#13
Yingxia Ning, Yinghong Cui, Xiang Li, Xiaocheng Cao, A Chen, Chang Xu, Jianguo Cao, Xin Luo
Among recent concepts in the cancer biology field, the tumor microenvironment is highly associated with cancer stem cells, and plays a key role in tumor progression. This study aimed to explore the mechanism that the stemness induction of SKOV3 cell line by macrophages derived from THP-1 cells, which was co-cultured with SKOV3-derived ovarian cancer stem-like cells (OCSLCs). Sphere formation, soft agar colony formation, and expression levels of CD133 and CD44 were assessed to reflect OCSLC properties. ELISA was used to evaluate secretion profile changes in macrophages co-cultured with or without SKOV3-derived OCSLCs...
April 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29652608/immunomodulatory-role-of-stem-cell-from-human-exfoliated-deciduous-teeth-on-periodontal-regeneration
#14
Xianling Gao, Zongshan Shen, Meiliang Guan, Qiting Huang, Lingling Chen, Wei Qin, Xiaohu Ge, Haijia Chen, Yin Xiao, Zhengmei Lin
Periodontitis is initiated by the infection of periodontal bacteria and subsequent tissue inflammation due to immunoreaction, eventually leading to periodontal apparatus loss. Stem cells from human exfoliated deciduous teeth (SHEDs) have exhibited beneficial characteristics in dental tissue regeneration. However, the immunomodulatory functions of SHEDs have not been elucidated in the context of periodontitis treatment. In this study, we investigated the potential immunomodulatory effects of SHEDs on experimental periodontitis and demonstrated that multi-dose delivery of SHEDs led to periodontal tissue regeneration...
March 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29652553/mahonia-oiwakensis-extract-and-its-bioactive-compounds-exert-anti-inflammatory-activities-and-vegf-production-through-m2-macrophagic-polarization-and-stat6-activation
#15
Yea-Chen Liu, Yu-Ying Hsiao, Kuo-Lung Ku, Hui-Fen Liao, Wei-Chun Chao
Macrophages play an indispensable role in the host immune defense. Macrophages can undergo polarization into classically (M1) and alternatively (M2) activated macrophages. M1 macrophages activate immune and inflammatory response, while M2 macrophages are involved in tissue remodeling. Mahonia oiwakensis (Mo) is a herbal medicine in Asia used for its anti-inflammatory and analgesic properties; however, the mechanism is unclear. This study analyzed the effect of Mo extracts and its effects on the polarization of both macrophage RAW264...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29649634/injectable-porous-biohybrid-hydrogels-incorporating-decellularized-tissue-components-for-soft-tissue-applications
#16
Yang Zhu, Sato Hideyoshi, Hongbin Jiang, Yasumoto Matsumura, Jenna L Dziki, Samuel T LoPresti, Luai Huleihel, Gabriela N F Faria, Leah C Fuhrman, Ricardo Lodono, Stephen F Badylak, William R Wagner
Biodegradable injectable hydrogels have been extensively studied and evaluated in various medical applications such as for bulking agents, drug delivery reservoirs, temporary barriers, adhesives, and cell delivery matrices. Where injectable hydrogels are intended to facilitate a healing response, it may be desirable to encourage rapid cellular infiltration into the hydrogel volume from the tissue surrounding the injection site. In this study, we developed a platform technique to rapidly form pores in a thermally responsive injectable hydrogel, poly(NIPAAm-co-VP-co-MAPLA) by using mannitol particles as porogens...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29649066/macrophage-polarization-favors-epithelial-repair-during-acute-respiratory-distress-syndrome
#17
Marc Garnier, Aude Gibelin, Arnaud A Mailleux, Véronique Leçon, Margarita Hurtado-Nedelec, Jamila Laschet, Grégoire Trebbia, Mathilde Neuville, Sébastien Tanaka, Bruno Crestani, Monique Dehoux, Christophe Quesnel
OBJECTIVES: Alveolar macrophage polarization and role on alveolar repair during human acute respiratory distress syndrome remain unclear. This study aimed to determine during human acute respiratory distress syndrome: the alveolar macrophage polarization, the effect of alveolar environment on macrophage polarization, and the role of polarized macrophages on epithelial repair. DESIGN: Experimental ex vivo and in vitro investigations. SETTING: Four ICUs in three teaching hospitals...
April 11, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29648626/regulation-of-intracellular-triiodothyronine-is-essential-for-optimal-macrophage-function
#18
Anne H van der Spek, Olga V Surovtseva, Kin Ki Jim, Adri van Oudenaren, Matthijs C Brouwer, Christina M J E Vandenbroucke-Grauls, Pieter J M Leenen, Diederik van de Beek, Arturo Hernandez, Eric Fliers, Anita Boelen
Innate immune cells, including macrophages, have recently been identified as novel target cells for thyroid hormone. We hypothesized that optimal intracellular concentrations of the active thyroid hormone triiodothyronine (T3) are essential for pro-inflammatory macrophage function. T3 is generated intracellularly by type 2 deiodinase (D2) and acts via the nuclear thyroid hormone receptor (TR). In zebrafish embryos, D2 knockdown increased mortality during pneumococcal meningitis. Primary murine D2KO macrophages exhibited impaired phagocytosis and partially reduced cytokine response to stimulation with bacterial endotoxin...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29643986/ajuba-receptor-mediates-the-internalization-of-tumor-secreted-grp78-into-macrophages-through-different-endocytosis-pathways
#19
Xiaoqin La, Lichao Zhang, Hanqing Li, Zhuoyu Li, Guisheng Song, Peng Yang, Yufei Yang
Glucose-regulated protein 78 (GRP78), an ER chaperone, is overexpressed in cancer cells. Solid tumor cells can secrete GRP78 that can promote tumor angiogenesis, differentiation of bone marrow-derived mesenchymal stem cells, tumor cell proliferation and polarization of tumor-associated macrophages. However, the mechanism by which GRP78 functions as a tumor promoter either by staying on the membrane to stimulate intracellular signals or directly entering into cytosolic remains unknown. Here, we reported that an endotoxin-free His-GRP78 protein was purified in vitro that simulates original secreted GRP78...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643359/il23-and-tgf-%C3%A3-diminish-macrophage-associated-metastasis-in-pancreatic-carcinoma
#20
S Mazher Hussain, Leighton F Reed, Bradley A Krasnick, Gustavo Miranda-Carboni, Ryan C Fields, Ye Bi, Abul Elahi, Abidemi Ajidahun, Paxton V Dickson, Jeremiah L Deneve, William G Hawkins, David Shibata, Evan S Glazer
The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-ß expression in PDAC. We hypothesized that IL23 expression is associated with metastatic development and survival in PDAC. We investigated IL23 and TGF-ß protein expression on resected PDAC patient tumor sections who were divided into short-term (<12 months) survivors and long-term (>30 months) survivors...
April 11, 2018: Scientific Reports
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