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https://www.readbyqxmd.com/read/28169558/validation-of-metagenomic-next-generation-sequencing-tests-for-universal-pathogen-detection
#1
Robert Schlaberg, Charles Y Chiu, Steve Miller, Gary W Procop, George Weinstock
CONTEXT: -Metagenomic sequencing can be used for detection of any pathogens using unbiased, shotgun next-generation sequencing (NGS), without the need for sequence-specific amplification. Proof-of-concept has been demonstrated in infectious disease outbreaks of unknown causes and in patients with suspected infections but negative results for conventional tests. Metagenomic NGS tests hold great promise to improve infectious disease diagnostics, especially in immunocompromised and critically ill patients...
February 7, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28162037/does-length-of-relationship-or-gender-predict-response-to-behavioral-diabetes-intervention
#2
Jonathan Sandberg, Jeremy B Yorgason, Lawrence Fisher, Ruth S Weinstock, Danielle Hessler, Jacqueline Dimmock, Paula M Trief
Purpose The purpose of the study was to determine, through secondary analysis, whether the length of a couple's relationship and the participants' gender are associated with glycemic response to a type 2 diabetes (T2D) behavioral couples-based intervention. Methods A randomized trial was conducted to test the impact of a couples-level, telephone-based behavioral intervention on hemoglobin A1C in patients with T2D. One hundred and four patients and partners participated in the couples intervention arm, and 94 individuals participated in the individual arm...
February 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28152570/niacin-intake-and-risk-of-skin-cancer-in-us-women-and-men
#3
Sang Min Park, Tricia Li, Shaowei Wu, Wen-Qing Li, Martin Weinstock, Abrar A Qureshi, Eunyoung Cho
A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], and melanoma). We prospectively evaluated whether total, dietary and supplemental niacin intake was associated with skin cancer risk based on 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010)...
February 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28151717/synergistic-drug-combinations-with-a-cdk4-6-inhibitor-in-t-cell-acute-lymphoblastic-leukemia
#4
Yana Pikman, Gabriela Alexe, Giovanni Roti, Amy Saur Conway, Andrew Furman, Emily S Lee, Andrew E Place, Sunkyu Kim, Chitra Saran, Rebecca Modiste, David M Weinstock, Marian Harris, Andrew L Kung, Lewis B Silverman, Kimberly Stegmaier
PURPOSE: While significant progress has been made in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), many patients will require additional therapy for relapsed/refractory disease. Cyclin D3 (CCND3) and CDK6 are highly expressed in T-ALL and have been effectively targeted in mutant NOTCH1-driven mouse models of this disease with a CDK4/6 small-molecule inhibitor. Combination therapy, however, will be needed for the successful treatment of human disease. EXPERIMENTAL DESIGN: We performed preclinical drug testing using a panel of T-ALL cell lines first with LEE011, a CDK4/6 inhibitor, and next with the combination of LEE011 with a panel of drugs relevant to T-ALL treatment...
November 9, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28112011/optimal-duration-of-continuous-video-electroencephalography-in-term-infants-with-hypoxic-ischemic-encephalopathy-and-therapeutic-hypothermia
#5
Naeem Mahfooz, Arie Weinstock, Bushra Afzal, Mariam Noor, David Vargas Lowy, Osman Farooq, Sarah G Finnegan, Satyan Lakshminrusimha
Continuous video-electroencephalography (EEG) is an important diagnostic and prognostic tool in newborns with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. The optimal duration of continuous video-EEG during whole-body hypothermia is not known. We conducted a retrospective study of 35 neonates with hypoxic-ischemic encephalopathy undergoing whole-body hypothermia with continuous video-EEG. EEG ictal changes were detected in 9/35 infants (26%). Of these 9 infants, the seizures were initially observed within 30 minutes of EEG monitoring in 6 (67%), within 24 hours in 2 (22%), and during rewarming in 1 infant (11%)...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28099212/dysfunctional-tear-syndrome-dry-eye-disease-and-associated-tear-film-disorders-new-strategies-for-diagnosis-and-treatment
#6
REVIEW
Mark S Milner, Kenneth A Beckman, Jodi I Luchs, Quentin B Allen, Richard M Awdeh, John Berdahl, Thomas S Boland, Carlos Buznego, Joseph P Gira, Damien F Goldberg, David Goldman, Raj K Goyal, Mitchell A Jackson, James Katz, Terry Kim, Parag A Majmudar, Ranjan P Malhotra, Marguerite B McDonald, Rajesh K Rajpal, Tal Raviv, Sheri Rowen, Neda Shamie, Jonathan D Solomon, Karl Stonecipher, Shachar Tauber, William Trattler, Keith A Walter, George O Waring, Robert J Weinstock, William F Wiley, Elizabeth Yeu
Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of diagnosis and treatment guidelines pertaining to disorders resulting in DTS, including the Delphi panel treatment recommendations for DTS (2006), the International Dry Eye Workshop (DEWS) (2007), the Meibomian Gland Dysfunction (MGD) Workshop (2011), and the updated Preferred Practice Pattern guidelines from the American Academy of Ophthalmology pertaining to dry eye and blepharitis (2013)...
January 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28097202/distinct-effects-of-obesity-and-puberty-on-risk-and-age-at-onset-of-pediatric-ms
#7
Tanuja Chitnis, Jennifer Graves, Bianca Weinstock-Guttman, Anita Belman, Cody Olsen, Madhusmita Misra, Gregory Aaen, Leslie Benson, Meghan Candee, Mark Gorman, Benjamin Greenberg, Lauren Krupp, Timothy Lotze, Soe Mar, Jayne Ness, John Rose, Jennifer Rubin, Teri Schreiner, Jan Tillema, Amy Waldman, Moses Rodriguez, Charlie Casper, Emmanuelle Waubant
OBJECTIVE: The aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS. METHODS: Case-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex- and age-stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset for MS cases...
December 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28088997/predictors-of-actinic-keratosis-count-in-patients-with-multiple-keratinocyte-carcinomas-a-cross-sectional-study
#8
Julia A Siegel, Adam J Luber, Martin A Weinstock
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28034071/relapsed-or-refractory-double-expressor-and-double-hit-lymphomas-have-inferior-progression-free-survival-after-autologous-stem-cell-transplantation
#9
Alex F Herrera, Matthew Mei, Lawrence Low, Haesook T Kim, Gabriel K Griffin, Joo Y Song, Reid W Merryman, Victoria Bedell, Christine Pak, Heather Sun, Tanya Paris, Tracey Stiller, Jennifer R Brown, Lihua E Budde, Wing C Chan, Robert Chen, Matthew S Davids, Arnold S Freedman, David C Fisher, Eric D Jacobsen, Caron A Jacobson, Ann S LaCasce, Joyce Murata-Collins, Auayporn P Nademanee, Joycelynne M Palmer, German A Pihan, Raju Pillai, Leslie Popplewell, Tanya Siddiqi, Aliyah R Sohani, Jasmine Zain, Steven T Rosen, Larry W Kwak, David M Weinstock, Stephen J Forman, Dennis D Weisenburger, Young Kim, Scott J Rodig, Amrita Krishnan, Philippe Armand
Purpose Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associated with poor outcomes after standard chemoimmunotherapy. Data are limited regarding outcomes of patients with relapsed or refractory (rel/ref) DEL or DHL who undergo autologous stem-cell transplantation (ASCT). We retrospectively studied the prognostic impact of DEL and DHL status on ASCT outcomes in patients with rel/ref DLBCL. Methods Patients with chemotherapy-sensitive rel/ref DLBCL who underwent ASCT at two institutions and in whom archival tumor material was available were enrolled...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28028023/incomplete-inhibition-by-eculizumab-mechanistic-evidence-for-residual-c5-activity-during-strong-complement-activation
#10
Markus J Harder, Nadine Kuhn, Hubert Schrezenmeier, Britta Höchsmann, Inge von Zabern, Christof Weinstock, Thomas Simmet, Daniel Ricklin, John D Lambris, Arne Skerra, Markus Anliker, Christoph Q Schmidt
Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the complement protein C5 and shows remarkable clinical benefits in certain complement-mediated diseases. However, several reports suggest that activation of C5 is not always completely suppressed in patients even under excess of eculizumab over C5 indicating that residual C5 activity may derogate the drug's therapeutic benefit under certain conditions. By using eculizumab and the tick-derived C5 inhibitor coversin we determine conditions ex vivo in which C5-inhibition is incomplete...
December 27, 2016: Blood
https://www.readbyqxmd.com/read/28004335/self-determination-theory-and-weight-loss-in-a-diabetes-prevention-program-translation-trial
#11
Paula M Trief, Donald Cibula, Linda M Delahanty, Ruth S Weinstock
We examined self-determination theory (SDT) and weight loss, and hypothesized that the Diabetes Prevention Program's (DPP) intervention would result in an increase in autonomous regulation of motivation (AR) in participants. Further, that those with higher AR, and those who perceived educators as supporting SDT-defined needs, would lose more weight. Support, Health Information, Nutrition and Exercise (SHINE) Study data (N = 257) were analyzed. SHINE was a randomized, controlled DPP translation trial (2-years, telephonic, primary care staff)...
December 21, 2016: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28002396/q-a-joel-weinstock
#12
Neil Savage
No abstract text is available yet for this article.
21, 2016: Nature
https://www.readbyqxmd.com/read/27996319/hypoglycemia-in-older-adults-with-type-1-diabetes
#13
Stephanie N DuBose, Ruth S Weinstock, Roy W Beck, Anne L Peters, Grazia Aleppo, Richard M Bergenstal, Henry Rodriguez, Joseph F Largay, Elaine M Massaro, Irl B Hirsch
BACKGROUND: Hypoglycemia is a major concern in older adults with type 1 diabetes (T1D) and there is limited knowledge in this population. We examined data from 199 adults, ≥60 years of age, who participated in a T1D Exchange study assessing factors associated with severe hypoglycemia (SH) in older adults with T1D: 100 with SH in the prior year and 99 with no SH in prior 3 years (mean age 68; mean diabetes duration 40 years; 47% female; 92% non-Hispanic white). Hypoglycemia was assessed with up to 14 days of blinded continuous glucose monitoring (CGM)...
December 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27993305/postpartum-headaches
#14
Michael B Weinstock, Jenny M Jaque, Mel Herbert, Paul Jhun
No abstract text is available yet for this article.
January 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27977856/nematodes-and-human-therapeutic-trials-for-inflammatory-disease
#15
David E Elliott, Joel V Weinstock
Helminth infections likely provide a protective influence against some immune-mediated and metabolic diseases since helminth infection dramatically decreased in developed countries shortly before the explosive rise in the prevalence of these diseases. The capacity of helminths to activate immune-regulatory circuits in their hosts and to modulate the composition of intestinal flora appears to be the mechanisms of protective action. Animal models of disease show that various helminth species prevent and/or block inflammation in various organs in a diverse range of diseases...
December 15, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27941472/isolation-of-methicillin-resistant-staphylococcus-aureus-and-multidrug-resistant-elizabethkingia-meningoseptica-from-neonates-within-minutes-of-birth
#16
Brenda A Kwambana-Adams, Claire S Laxton, Ebenezer Foster-Nyarko, Claire S Laxton, George Weinstock, Martin Antonio
No abstract text is available yet for this article.
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27936634/influence-of-polyoxometalate-protecting-ligands-on-catalytic-aerobic-oxidation-at-the-surfaces-of-gold-nanoparticles-in-water
#17
Mingfu Zhang, Jingcheng Hao, Alevtina Neyman, Yifeng Wang, Ira A Weinstock
Metal oxide cluster-anion (polyoxometalate, or POM) protecting ligands, [α-PW11O39](7-) (1), modify the rates at which 14 nm gold nanoparticles (Au NPs) catalyze an important model reaction, the aerobic (O2) oxidation of CO to CO2 in water. At 20 °C and pH 6.2, the following stoichiometry was observed: CO + O2 + H2O = CO2 + H2O2. After control experiments verified that the H2O2 product was sufficiently stable and did not react with 1 under turnover conditions, quantitative analysis of H2O2 was used to monitor the rates of CO oxidation, which increased linearly with the percent coverage of the Au NPs by 1 (0-64% coverage, with the latter value corresponding to 211 ± 19 surface-bound molecules of 1)...
December 12, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27923871/serum-lipid-profile-changes-predict-neurodegeneration-in-interferon-%C3%AE-1a-treated-multiple-sclerosis-patients
#18
Tomas Uher, Kelly Fellows, Dana Horakova, Robert Zivadinov, Manuela Vaneckova, Lukas Sobisek, Michaela Tyblova, Zdenek Seidl, Jan Krasensky, Niels Bergsland, Bianca Weinstock-Guttman, Eva Havrdova, Murali Ramanathan
The purpose of this work was to determine whether changes in cholesterol profiles after interferon-β (IFN-β)1a treatment initiation following the first demyelinating event suggestive of multiple sclerosis are associated with clinical and MRI outcomes over 4 years. A group of 131 patients (age: 27.9 ± 7.8 years, 63% female) with serial 3-monthly clinical and 12-monthly MRI follow-ups over 4 years were investigated. Serum cholesterol profiles, including total cholesterol (TC), HDL cholesterol (HDL-C), and LDL cholesterol (LDL-C) were obtained at baseline, 1 month, 3 months, and every 6 months thereafter...
February 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/27923840/osimertinib-for-the-treatment-of-metastatic-epidermal-growth-factor-t970m-positive-non-small-cell-lung-cancer
#19
Sean Khozin, Chana Weinstock, Gideon M Blumenthal, Joyce Cheng, Kun He, Luning Zhuang, Hong Zhao, Rosane Charlab Orbach, Ingrid Fan, Patricia Keegan, Richard Pazdur
On November 13, 2015, FDA granted accelerated approval to osimertinib (TAGRISSO™; AstraZeneca), a breakthrough therapy-designated drug for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, with progression on or after EGFR tyrosine kinase inhibitor therapy. Approval was based on durable tumor response rates in two single-arm, multicenter trials: the dose extension cohort of a first-in-human trial (AURA extension; n=201) and a fixed-dose, activity-estimating trial (AURA2; n=210)...
December 6, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27918139/an-observational-study-to-assess-brain-mri-change-and-disease-progression-in-multiple-sclerosis-clinical-practice-the-ms-mrius-study
#20
Robert Zivadinov, Nasreen Khan, Jennie Medin, Pia Christoffersen, Jennifer Price, Jonathan R Korn, Ian Bonzani, Michael G Dwyer, Niels Bergsland, Ellen Carl, Diego Silva, Bianca Weinstock-Guttman
BACKGROUND & PURPOSE: To describe methodology, interim baseline, and longitudinal magnetic resonance imaging (MRI) acquisition parameter characteristics of the multiple sclerosis clinical outcome and MRI in the United States (MS-MRIUS). MATERIAL & METHODS: The MS-MRIUS is an ongoing longitudinal and retrospective study of MS patients on fingolimod. Clinical and brain MRI image scan data were collected from 600 patients across 33 MS centers in the United States. MRI brain outcomes included change in whole-brain volume, lateral ventricle volume, T2- and T1-lesion volumes, and new/enlarging T2 and gadolinium-enhancing lesions...
December 5, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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