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https://www.readbyqxmd.com/read/29656457/late-sampling-for-automated-culture-to-extend-the-platelet-shelf-life-to-5-days-in-germany
#1
Tanja Vollmer, Mareike Dabisch-Ruthe, Melanie Weinstock, Cornelius Knabbe, Jens Dreier
BACKGROUND: Bacterial contamination of platelet concentrates (PCs) is still a major challenge in transfusion medicine. Different methodologic concepts and screening strategies have been developed and investigated concerning their usability. We evaluated the feasibility of BacT/ALERT automated culture (BacT/A, bioMérieux) with late sampling after 3 days at the earliest. STUDY DESIGN AND METHODS: Twenty-four bacterial strains isolated from PCs and six relevant strains from reference stocks were spiked into apheresis-derived PCs (10-60 colony-forming units [CFU]/bag)...
April 15, 2018: Transfusion
https://www.readbyqxmd.com/read/29653437/early-infectious-exposures-are-not-associated-with-increased-risk-of-pediatric-onset-multiple-sclerosis
#2
Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves
OBJECTIVE: We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS: This was a case-control study of children with MS or clinically isolated syndrome (CIS) and healthy controls enrolled at sixteen clinics participating in the US Network of Pediatric MS Centers. Parents completed a comprehensive environmental questionnaire that captured early infectious exposures, habits, and illnesses in the first five years of life...
March 26, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29648900/no-evidence-of-disease-activity-in-patients-receiving-fingolimod-at-private-or-academic-centers-in-clinical-practice-a-retrospective-analysis-of-the-multiple-sclerosis-clinical-and-magnetic-resonance-imaging-outcomes-in-the-usa-ms-mrius-study
#3
Robert Zivadinov, Nasreen Khan, Jonathan R Korn, Ellen Lathi, Jason Silversteen, Jonathan Calkwood, Scott Kolodny, Diego Silva, Jennie Medin, Bianca Weinstock-Guttman
OBJECTIVE: The impact of multiple sclerosis (MS) center type on outcomes has not been investigated. This study aimed to evaluate baseline characteristics and clinical and magnetic resonance imaging (MRI) outcomes in patients with MS receiving fingolimod over 16 months' follow-up at private or academic centers in the USA. METHODS: Clinical and MRI data collected in clinical practice from patients initiating fingolimod were stratified by center type and retrospectively analyzed...
April 12, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29627017/effect-of-teriflunomide-on-gray-and-white-matter-brain-pathology-in-multiple-sclerosis-using-volumetric-and-diffusion-tensor-imaging-mri-measures
#4
Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Ellen Carl, Hanna Kolb, David Hojnacki, Bianca Weinstock-Guttman
OBJECTIVES: To investigate the effect of teriflunomide on microstructural pathology in the gray matter (GM) and white matter (WM), as measured by changes in brain volume and diffusion-tensor imaging (DTI) in patients with multiple sclerosis (MS). METHODS: 30 relapsing MS patients and 20 healthy controls (HCs) were enrolled in the study and followed prospectively for 12 months with clinical and 3T MRI examinations. Of those, 26 MS patients and 18 HCs completed the 6-month and 22 MS and 16 HCs patients the 12-month follow-up...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29620698/complex-polypharmacy-in-patients-with-schizophrenia-spectrum-disorders-before-a-psychiatric-hospitalization-prescribing-patterns-and-associated-clinical-features
#5
Brandon A Gaudiano, Carolina Guzman Holst, Alexandra Morena, Lauren E Reeves, Valerie J Sydnor, Gary Epstein-Lubow, Lauren M Weinstock
BACKGROUND: Current evidence-based guidelines provide unclear support for many common polypharmacy practices in schizophrenia. Excessive or complex polypharmacy (≥4 psychotropics) has been studied in patients with bipolar disorder, but not in schizophrenia to date. METHODS: We conducted a digital medical record data extraction of 829 patients consecutively admitted to a psychiatric hospital and diagnosed as having schizophrenia-spectrum disorders. RESULTS: In those prescribed psychiatric medication preadmission, 28...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29603324/complexities-of-perceived-and-actual-performance-in-pathology-interpretation-a-comparison-of-cutaneous-melanocytic-skin-and-breast-interpretations
#6
Patricia A Carney, Paul D Frederick, Lisa M Reisch, Linda Titus, Stevan R Knezevich, Martin A Weinstock, Michael W Piepkorn, Raymond L Barnhill, David E Elder, Donald L Weaver, Joann G Elmore
BACKGROUND: Little is known about how pathologists process differences between actual and perceived interpretations. OBJECTIVE: To compare perceived and actual diagnostic agreement before and after educational interventions. METHODS: Pathologists interpreted test sets of skin and/or breast specimens that included benign, atypical, in situ and invasive lesions. Interventions involved self-directed learning, one skin and one breast, that showed pathologists how their interpretations compared to a reference diagnoses...
March 30, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29590548/the-verge-of-collapse
#7
Matthew Weinstock, Anand Vaidya, Souheil El-Chemaly, John Godleski, Elizabeth Henske
New England Journal of Medicine, Volume 378, Issue 13, March 2018.
March 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29574353/preliminary-investigation-of-cognitive-function-in-aged-multiple-sclerosis-patients-challenges-in-detecting-comorbid-alzheimer-s-disease
#8
Shumita Roy, Allison Drake, Stephanie Snyder, Breana Cline, Anjum Khan, Tom Fuchs, Robert Zivadinov, Bianca Weinstock-Guttman, Kinga Szigeti, Ralph H B Benedict
BACKGROUND: Cognitive impairment can be seen in patients of all ages with multiple sclerosis (MS). However, there is limited research on neurocognitive disorder in older adults with MS and how to detect Alzheimer's disease (AD) or its prodromal stage, amnestic mild cognitive impairment (aMCI). Thus, the MS clinician is challenged to discriminate between signs of MS-related cognitive decline versus a secondary neurodegenerative process. OBJECTIVE: Compare cognition in older MS patients to patients with AD and aMCI...
March 13, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29574090/how-data-can-deliver-for-dermatology
#9
EDITORIAL
Katrina Abuabara, Maryam M Asgari, Suephy C Chen, Robert P Dellavalle, Sunil Kalia, Aaron M Secrest, Jonathan I Silverberg, James A Solomon, Martin A Weinstock, Jashin J Wu, Mary-Margaret Chren
No abstract text is available yet for this article.
March 21, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29571854/effect-of-switching-from-glatiramer-acetate-20-mg-daily-to-glatiramer-acetate-40-mg-three-times-a-week-on-gray-and-white-matter-pathology-in-subjects-with-relapsing-multiple-sclerosis-a-longitudinal-dti-study
#10
Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Eleonora Tavazzi, Deepa P Ramasamy, Jackie Durfee, Mariya Cherneva, Ellen Carl, Jillian Carl, Channa Kolb, David Hojnacki, Bianca Weinstock-Guttman
BACKGROUND: Glatiramer acetate (GA) 40 mg × 3/weekly was approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). While the beneficial effect of GA 20 mg/daily in MS patients on non-conventional MRI measures has been demonstrated, the effect of GA 40 mg × 3/weekly at the microstructural tissue level has yet to be explored. OBJECTIVE: To investigate the effect of switching from GA 20 mg/daily to GA 40 mg × 3/weekly on the evolution of microstructural changes in the thalamus and normal appearing white matter (NAWM), using diffusion tensor imaging (DTI)...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29559113/meta-analysis-of-the-lung-microbiota-in-pulmonary-tuberculosis
#11
Bo-Young Hong, Joseph N Paulson, O Colin Stine, George M Weinstock, Jorge L Cervantes
The lung microbiota has received less attention compared to other body sites, in part because its study carries special technological difficulties related to obtaining reliable samples as compared to other body niches. The limited number of studies on the sputum microbiota on TB patients and controls available so far have reported inconsistent, and sometimes, contradictory results. Aiming to clarify if changes in the lung microbiota composition are associated with pulmonary TB, we performed a meta-analysis of available data on microbiota of the lower respiratory tract in TB patients and healthy controls...
March 2018: Tuberculosis
https://www.readbyqxmd.com/read/29551267/b-cell-specific-diversion-of-glucose-carbon-utilization-reveals-a-unique-vulnerability-in-b-cell-malignancies
#12
Gang Xiao, Lai N Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M Weinstock, Thomas G Graeber, Markus Müschen
B cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B cells and their ability to retain redox homeostasis. While the serine/threonine-protein phosphatase 2A (PP2A) was identified as a tumor suppressor in multiple types of cancer, our genetic studies revealed an essential role of PP2A in B cell tumors. Thereby, PP2A redirects glucose carbon utilization from glycolysis to the pentose phosphate pathway (PPP) to salvage oxidative stress. This unique vulnerability reflects constitutively low PPP activity in B cells and transcriptional repression of G6PD and other key PPP enzymes by the B cell transcription factors PAX5 and IKZF1...
March 6, 2018: Cell
https://www.readbyqxmd.com/read/29524584/pathologist-characteristics-associated-with-accuracy-and-reproducibility-of-melanocytic-skin-lesion-interpretation
#13
David E Elder, Mike Piepkorn, Raymond L Barnhill, Gary M Longton, Heidi D Nelson, Stevan R Knezevich, Margaret S Pepe, Patricia A Carney, Linda J Titus, Tracy Onega, Anna N A Tosteson, Martin A Weinstock, Joann G Elmore
BACKGROUND: Diagnostic interpretations of melanocytic skin lesions vary widely among pathologists, yet the underlying reasons remain unclear. OBJECTIVE: Identify pathologist characteristics associated with rates of accuracy and reproducibility. METHODS: Pathologists independently interpreted the same set of biopsies of melanocytic lesions on two occasions. Diagnoses were categorized into one of five classes according to the MPATH-Dx© system...
March 7, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29517973/molecular-immunohaematology-round-table-discussions-at-the-aabb-annual-meeting-orlando-2016
#14
Willy A Flegel, Qing Chen, Lilian Castilho, Margaret A Keller, Ellen B Klapper, William J Lane, France Pirenne, Gary Stack, Maryse St-Louis, Christopher A Tormey, Dan A Waxman, Christof Weinstock, Silvano Wendel, Gregory A Denomme
No abstract text is available yet for this article.
February 14, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29511293/author-correction-prevention-of-retinal-degeneration-in-a-rat-model-of-smith-lemli-opitz-syndrome
#15
Steven J Fliesler, Neal S Peachey, Josi Herron, Kelly M Hines, Nadav I Weinstock, Sriganesh Ramachandra Rao, Libin Xu
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29508244/an-update-on-the-use-of-disease-modifying-therapy-in-pregnant-patients-with-multiple-sclerosis
#16
REVIEW
Caila Vaughn, Aisha Bushra, Channa Kolb, Bianca Weinstock-Guttman
The active management of multiple sclerosis (MS) has been made possible during the last two decades with the advent of disease-modifying therapies (DMTs), leading to improved clinical outcomes for many patients. Furthermore, with the realization that MS does not adversely affect pregnancy outcome and that pregnancy does not have an overall negative impact on the long-term disease course of MS, the importance of appropriate counseling and discussion of future pregnancy plans with women of childbearing age is greater than ever...
March 5, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29507538/pregnancy-outcomes-from-the-branded-glatiramer-acetate-pregnancy-database
#17
Magnhild Sandberg-Wollheim, Orit Neudorfer, Augusto Grinspan, Bianca Weinstock-Guttman, Judith Haas, Guillermo Izquierdo, Claire Riley, Amy Perrin Ross, Peleg Baruch, Talya Drillman, Patricia K Coyle
Background: Appropriate counseling and treatment for women with multiple sclerosis (MS) who may become pregnant requires an understanding of the effects of exposure to disease-modifying therapies (DMTs) during pregnancy. Current reports and studies are limited in their usefulness, mostly by small sample size. Branded glatiramer acetate (GA) is a DMT approved for the treatment of relapsing forms of MS. For more than 2 decades, it has been shown to be efficacious and to have a favorable safety profile...
January 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29505863/impact-of-topical-fluorouracil-cream-on-costs-of-treating-keratinocyte-carcinoma-nonmelanoma-skin-cancer-and-actinic-keratosis
#18
Jean Yoon, Ciaran S Phibbs, Adam Chow, Martin A Weinstock
BACKGROUND: It is unknown whether treatment costs of Keratinocyte Carcinoma (KC) and Actinic Keratosis (AK) can be lowered by spending more on chemoprevention. OBJECTIVE: We examine the impact of one-course treatment of topical fluorouracil on the face and ears on KC and AK treatment costs over three years. METHODS: The VAKCC trial compared the efficacy of topical fluorouracil cream, 5%, vs vehicle control cream for reducing KC risk. Trial data and administrative data on costs and utilization were analyzed to measure post-randomization encounters and treatment costs for KC and AK care...
March 2, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29498537/complementary-and-alternative-medicine-usage-by-multiple-sclerosis-patients-results-from-a-prospective-clinical-study
#19
Soohyun Kim, Lawrence Chang, Bianca Weinstock-Guttman, Sirin Gandhi, Dejan Jakimovski, Ellen Carl, Robert Zivadinov, Murali Ramanathan
OBJECTIVES: To investigate the factors associated with complementary and alternative medicine (CAM) usage by multiple sclerosis (MS) patients. Design, Setting/Location: Single-center, prospective clinical study at an academic MS center in the northeastern United States. METHODS: This study included CAM data from 524 MS patients and 304 healthy controls (HC) enrolled in a prospective study of clinical, neuroimaging, and environmental risk factors in MS at an academic MS Center...
March 2, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29487712/inhibition-of-mtorc1-c2-signaling-improves-anti-leukemia-efficacy-of-jak-stat-blockade-in-crlf2-rearranged-and-or-jak-driven-philadelphia-chromosome-like-acute-b-cell-lymphoblastic-leukemia
#20
Qi Zhang, Ce Shi, Lina Han, Nitin Jain, Kathryn G Roberts, Helen Ma, Tianyu Cai, Antonio Cavazos, Yoko Tabe, Rodrigo O Jacamo, Hong Mu, Yang Zhao, Jing Wang, Shuo-Chieh Wu, Fenglin Cao, Zhihong Zeng, Jin Zhou, Yingchang Mi, Elias J Jabbour, Ross Levine, Sarah K Tasian, Charles G Mullighan, David M Weinstock, David A Fruman, Marina Konopleva
Patients with cytokine receptor-like factor 2 rearranged ( CRLF2 -re) subgroup Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like B-ALL) have a high relapse rate and poor clinical outcomes. CRFL2 -re Ph-like B-ALL is characterized by heightened activation of multiple signaling pathways, including the JAK/STAT and PI3K/AKT/mTOR pathways. We hypothesized that the combined inhibition by JAK2 and mTOR inhibitors would induce an additive antileukemia effect in CRLF2 -re Ph-like B-ALL. In this study, we tested the antileukemia efficacy of the type I JAK inhibitor ruxolitinib and type II JAK inhibitor NVP-BBT594 (hereafter abbreviated BBT594) [1] alone and combined with allosteric mTOR inhibitor rapamycin and a second generation ATP-competitive mTOR kinase inhibitor AZD2014...
January 30, 2018: Oncotarget
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