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https://www.readbyqxmd.com/read/28543746/rosacea-is-associated-with-helicobacter-pylori-a-systematic-review-and-meta-analysis
#1
REVIEW
Astrid-Helene R Jørgensen, Alexander Egeberg, Robin Gideonsson, Leonard B Weinstock, Erik P Thyssen, Jacob P Thyssen
BACKGROUND: Rosacea is a common skin disease characterized by facial erythema, telangiectasia, papules, and pustules. Helicobacter pylori infection has been suggested to play a role in the etiopathogenesis of rosacea. OBJECTIVE: Systematically review and meta-analyse the relationship between rosacea and infection with Helicobacter pylori . METHODS: A literature search was performed using PubMed, EMBASE, and Web of Science. Data extraction and analyses were performed on descriptive data...
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28535088/just-friends-the-role-of-friendship-in-lesbians-lives
#2
Jacqueline S Weinstock, Esther D Rothblum
No abstract text is available yet for this article.
May 23, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28532759/5-fluorouracil-for-actinic-keratosis-treatment-and-chemoprevention-a-randomized-controlled-trial
#3
Joanna L Walker, Julia A Siegel, Moniyka Sachar, Hyemin Pomerantz, Suephy C Chen, Susan M Swetter, Robert P Dellavalle, George P Stricklin, Abrar A Qureshi, John J DiGiovanna, Martin A Weinstock
No abstract text is available yet for this article.
June 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28531824/is-subclinical-gambling-really-subclinical
#4
Jeremiah Weinstock, Laura M April, Selmi Kallmi
Gambling disorder and substance use disorders (SUD) overlap in terms of etiology and diagnostic constructs (e.g., preoccupation, loss of control), yet diagnostic thresholds for the disorders are different. Currently, endorsing 2-3 gambling disorder criteria does not warrant a diagnosis while endorsing 2-3 SUD criteria does. The aim of this study was to examine whether subclinical gamblers (i.e., endorsing 2-3 gambling disorder criteria) experience psychosocial dysfunction equivalent to individuals who are diagnosed with mild severity SUD (i...
May 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28528854/erratum-to-creation-and-validation-of-a-simulator-for-neonatal-brain-ultrasonography-a-pilot-study-acad-radiol-2017-24-76-83
#5
Andy Tsai, Carol E Barnewolt, Sanjay P Prabhu, Reimi Yonekura, Andrew Hosmer, Noah E Schulz, Peter H Weinstock
No abstract text is available yet for this article.
May 18, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28508392/polyoxometalate-engineered-building-blocks-with-gold-cores-for-the-self-assembly-of-responsive-water-soluble-nanostructures
#6
Yizhan Wang, Manoj Raula, Yifeng Wang, Offer Zeiri, Sourav Chakraborty, Gal Gan-Or, Eyal Gadot, Ira A Weinstock
The controlled assembly of gold nanoparticles (AuNPs) with the size of quantum dots into predictable structures is extremely challenging as it requires the quantitatively and topologically precise placement of anisotropic domains on their small, approximately spherical surfaces. We herein address this problem by using polyoxometalate leaving groups to transform 2 nm diameter gold cores into reactive building blocks with hydrophilic and hydrophobic surface domains whose relative sizes can be precisely tuned to give dimers, clusters, and larger micelle-like organizations...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28500658/evaluation-of-photoaging-scales-in-an-elderly-male-population
#7
K Korgavkar, M A Weinstock, K C Lee
Photo-induced aging is a natural part of the aging process, but represents a common complaint of both medical and cosmetic dermatology patients. There are many photonumeric grading scales used to assess photo-induced aging, including several based on ethnicity (Caucasians, Asians), and cosmetic units of the face (1), however those specifically validated for older men are lacking. Current photonumeric scales were created using predominantly female subjects age 45 and younger (2-4). Our study sought to evaluate the inter-rater reliability of commonly used photonumeric grading scales in a population of elderly male subjects...
May 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28499033/large-scale-recoding-of-a-bacterial-genome-by-iterative-recombineering-of-synthetic-dna
#8
Yu Heng Lau, Finn Stirling, James Kuo, Michiel A P Karrenbelt, Yujia A Chan, Adam Riesselman, Connor A Horton, Elena Schäfer, David Lips, Matthew T Weinstock, Daniel G Gibson, Jeffrey C Way, Pamela A Silver
The ability to rewrite large stretches of genomic DNA enables the creation of new organisms with customized functions. However, few methods currently exist for accumulating such widespread genomic changes in a single organism. In this study, we demonstrate a rapid approach for rewriting bacterial genomes with modified synthetic DNA. We recode 200 kb of the Salmonella typhimurium LT2 genome through a process we term SIRCAS (stepwise integration of rolling circle amplified segments), towards constructing an attenuated and genetically isolated bacterial chassis...
May 12, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28480306/dendritic-cell-therapies-for-hematologic-malignancies
#9
REVIEW
Matthew Weinstock, Jacalyn Rosenblatt, David Avigan
Dendritic cells (DCs) are potent antigen-presenting cells that constitute a major component of the immune system's role in the recognition, elimination, and tolerance of cancer. The unique immunologic capabilities of DCs have recently been harnessed for therapeutic use with the creation of DC-based anti-tumor vaccines, several of which have moved into testing in clinical trials for hematologic malignancies. This review summarizes how treatment strategies using DC-based anti-tumor vaccines are advancing immunotherapeutic options for these diseases...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28447610/parp3-is-a-promoter-of-chromosomal-rearrangements-and-limits-g4-dna
#10
Tovah A Day, Jacob V Layer, J Patrick Cleary, Srijoy Guha, Kristen E Stevenson, Trevor Tivey, Sunhee Kim, Anna C Schinzel, Francesca Izzo, John Doench, David E Root, William C Hahn, Brendan D Price, David M Weinstock
Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements in human cells. We identify UBC9 and RAD50 as suppressors and 53BP1, DDB1 and poly(ADP)ribose polymerase 3 (PARP3) as promoters of chromosomal rearrangements across human cell types. We focus on PARP3 as it is dispensable for murine viability and has druggable catalytic activity...
April 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28443458/magnetic-resonance-imaging-as-a-noninvasive-method-for-longitudinal-monitoring-of-infusion-site-reactions-following-administration-of-a-novel-apomorphine-formulation
#11
Ronit Shaltiel-Karyo, Yonit Tsarfati, Anna Rubinski, Eduardo Zawoznik, Irena Weinstock, Mara Nemas, Yael S Schiffenbauer, Yuval Ramot, Abraham Nyska, Oron Yacoby-Zeevi
Infusion site reactions are common following subcutaneous infusion of drugs. Such reactions can lead to discontinuation of the treatment. Therefore, assessment of such reactions is essential during preclinical safety studies, and magnetic resonance imaging (MRI) can assist in evaluation. Here, in vivo and ex vivo MRI evaluations were used in addition to classical histopathology to assess the infusion site reaction to ND0701, a novel formulation of apomorphine base developed for the treatment of Parkinson's disease, in comparison to the commercial apomorphine hydrochloride (HCl) formulation...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28438070/creation-of-a-novel-simulator-for-minimally-invasive-neurosurgery-fusion-of-3d-printing-and-special-effects
#12
Peter Weinstock, Roberta Rehder, Sanjay P Prabhu, Peter W Forbes, Christopher J Roussin, Alan R Cohen
OBJECTIVE Recent advances in optics and miniaturization have enabled the development of a growing number of minimally invasive procedures, yet innovative training methods for the use of these techniques remain lacking. Conventional teaching models, including cadavers and physical trainers as well as virtual reality platforms, are often expensive and ineffective. Newly developed 3D printing technologies can recreate patient-specific anatomy, but the stiffness of the materials limits fidelity to real-life surgical situations...
April 25, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28431621/two-decades-of-glatiramer-acetate-from-initial-discovery-to-the-current-development-of-generics
#13
REVIEW
Bianca Weinstock-Guttman, Kavita V Nair, Joseph L Glajch, Tanmoy C Ganguly, Daniel Kantor
Multiple sclerosis (MS) is a chronic, incurable, inflammatory disease of the central nervous system (CNS). In the United States, several US Food and Drug Administration (FDA)-approved disease-modifying treatments (DMTs) are available, including glatiramer acetate (GA; Copaxone®), one of the most longstanding treatments. GA was discovered serendipitously in the late 1960s/early 1970s while attempting to produce a synthetic antigen capable of inducing experimental autoimmune encephalomyelitis (EAE), an animal model of autoimmune inflammatory CNS disorders, including MS...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28427793/contribution-of-health-care-factors-to-the-burden-of-skin-disease-in-the-united-states
#14
Henry W Lim, Scott A B Collins, Jack S Resneck, Jean L Bolognia, Julie A Hodge, Thomas A Rohrer, Marta J Van Beek, David J Margolis, Arthur J Sober, Martin A Weinstock, David R Nerenz, Wendy Smith Begolka, Jose V Moyano
The American Academy of Dermatology has developed an up-to-date national Burden of Skin Disease Report on the impact of skin disease on patients and on the US population. In this second of 3 manuscripts, data are presented on specific health care dimensions that contribute to the overall burden of skin disease. Through the use of data derived from medical claims in 2013 for 24 skin disease categories, these results indicate that skin disease health care is delivered most frequently to the aging US population, who are afflicted with more skin diseases than other age groups...
April 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28384130/state-specific-rates-of-primary-and-secondary-syphilis-among-men-who-have-sex-with-men-united-states-2015
#15
Alex de Voux, Sarah Kidd, Jeremy A Grey, Eli S Rosenberg, Thomas L Gift, Hillard Weinstock, Kyle T Bernstein
In 2015, the rate of reported primary and secondary syphilis in the United States was 7.5 cases per 100,000 population, nearly four times the previous lowest documented rate of 2.1 in 2000 (1). In 2015, 81.7% of male primary and secondary syphilis cases with information on the sex of the sex partner were among gay, bisexual, and other men who have sex with men (collectively referred to as MSM) (1). These data suggest a disproportionate incidence of disease among MSM. However, attempts to quantify this disparity have been hindered by limited data on the size of the MSM population at the state level...
April 7, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28377416/spectrum-of-immune-related-conditions-associated-with-risk-of-keratinocyte-cancers-among-elderly-adults-in-the-united-states
#16
Elizabeth L Yanik, Ruth M Pfeiffer, D Michael Freedman, Martin A Weinstock, Elizabeth K Cahoon, Sarah T Arron, Matthew Chaloux, M Kari Connolly, Priyadharsini Nagarajan, Eric A Engels
Elevated keratinocyte carcinoma (KC) risk is present with several immune-related conditions, e.g., solid organ transplantation and non-Hodgkin lymphoma. Because many immune-related conditions are rare, their relationships with KC have not been studied. We used Medicare claims to identify cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) cases in 2012, and controls matched on sex and age. All subjects were aged 65-95 years, of white race, and had attended ≥1 dermatologist visit in 2010-2011...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28373165/it-takes-a-village-to-unmask-hstl
#17
Noriaki Yoshida, David M Weinstock
In this issue of Cancer Discovery, McKinney and colleagues describe the genetics of hepatosplenic T-cell lymphoma, a rare subtype of T-cell lymphoma with unique clinical characteristics. The findings, specifically frequent mutations of STAT5B, PIK3CD, and the histone methyltransferase SETD2, may help guide translational efforts to target this deadly disease. Cancer Discov; 7(4); 352-3. ©2017 AACR.See related article by McKinney et al., p. 369.
April 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28369774/temporal-trends-in-healthcare-utilization-following-primary-melanoma-diagnosis-among-medicare-beneficiaries
#18
J P Lott, Q Wang, L J Titus, T Onega, H D Nelson, M A Weinstock, J G Elmore, A N A Tosteson
BACKGROUND: Despite increasing melanoma incidence in the United States, little is known about the impact of primary melanoma diagnosis on healthcare utilization and changes in utilization over time. OBJECTIVE: To evaluate population-based temporal trends in healthcare utilization following primary melanoma diagnosis. METHODS: We conducted a before-after multiple time series study of Medicare beneficiaries ages ≥66 years with primary melanoma diagnoses between 2000 and 2009 using the Surveillance, Epidemiology, and End Results-Medicare database...
March 30, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28369739/the-global-burden-of-melanoma-results-from-global-burden-of-disease-study-2015
#19
C Karimkhani, A C Green, T Nijsten, M A Weinstock, R P Dellavalle, M Naghavi, C Fitzmaurice
BACKGROUND: Despite recent improvements in prevention, diagnosis, and treatment, vast differences in melanoma burden still exist between populations. Comparative data can highlight these differences and lead to focused efforts to reduce the burden of melanoma. OBJECTIVES: To assess global, regional, and national melanoma incidence, mortality, and disability-adjusted life year (DALY) estimates from the Global Burden of Disease 2015 study. METHODS: Vital registration system and cancer registry data were used for melanoma mortality modeling...
March 30, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28356466/evidence-for-a-causal-relationship-between-low-vitamin-d-high-bmi-and-pediatric-onset-ms
#20
MULTICENTER STUDY
Milena A Gianfrancesco, Pernilla Stridh, Brooke Rhead, Xiaorong Shao, Edison Xu, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Maria Bäärnhielm, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Metayer, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant
OBJECTIVE: To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS). METHODS: We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels of 25(OH)D in serum using the estimated effect of each risk variant. A BMI GRS was also created that incorporates the cumulative effect of 97 variants associated with BMI...
April 25, 2017: Neurology
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