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https://www.readbyqxmd.com/read/28320349/mindfulness-based-interventions-in-epilepsy-a-systematic-review
#1
Karen Wood, Maggie Lawrence, Bhautesh Jani, Robert Simpson, Stewart W Mercer
BACKGROUND: Mindfulness based interventions (MBIs) are increasingly used to help patients cope with physical and mental long-term conditions (LTCs). Epilepsy is associated with a range of mental and physical comorbidities that have a detrimental effect on quality of life (QOL), but it is not clear whether MBIs can help. We systematically reviewed the literature to determine the effectiveness of MBIs in people with epilepsy. METHODS: Medline, Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, Allied and Complimentary Medicine Database, and PsychInfo were searched in March 2016...
March 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28289782/neuro-psychopharmacological-perspective-of-orphan-receptors-of-rhodopsin-class-a-family-of-g-protein-coupled-receptors
#2
REVIEW
Muhammad Zahid Khan, Ling He
BACKGROUND: In the central nervous system (CNS), G protein-coupled receptors (GPCRs) are the most fruitful targets for neuropsychopharmacological drug development. Rhodopsin (class A) is the most studied class of GPCR and includes orphan receptors for which the endogenous ligand is not known or is unclear. Characterization of orphan GPCRs has proven to be challenging, and the production pace of GPCR-based drugs has been incredibly slow. OBJECTIVE: Determination of the functions of these receptors may provide unexpected insight into physiological and neuropathological processes...
March 13, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28285739/neuropsychiatric-comorbidities-in-adults-with-phenylketonuria-a-retrospective-cohort-study
#3
Deborah A Bilder, Joyce A Kobori, Jessica L Cohen-Pfeffer, Erin M Johnson, Elaina R Jurecki, Mitzie L Grant
Adults with phenylketonuria (PKU) may experience neurologic and psychiatric disorders, including intellectual disability, anxiety, depression, and neurocognitive dysfunction. Identifying the prevalence and prevalence ratios of these conditions will inform clinical treatment. This nested, case-controlled study used International Classification of Diseases, Ninth Revision (ICD-9) codes from the MarketScan® insurance claims databases from 2006 to 2012 and healthcare claims data for US-based employer and government-sponsored health plans...
March 6, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28262662/epilepsy-and-intellectual-disability-linked-protein-shrm4-interaction-with-gababrs-shapes-inhibitory-neurotransmission
#4
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G Smart, Maria Passafaro
Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we report that Shrm4 is localized to synapses where it regulates dendritic spine morphology and interacts with the C terminus of GABAB receptors (GABABRs) to control their cell surface expression and intracellular trafficking via a dynein-dependent mechanism. Knockdown of Shrm4 in rat severely impairs GABABR activity causing increased anxiety-like behaviour and susceptibility to seizures...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28262620/effects-of-jasminum-multiflorum-leaf-extract-on-rodent-models-of-epilepsy-motor-coordination-and-anxiety
#5
Jonas I Addae, Ramish Pingal, Kheston Walkins, Renee Cruickshank, Farid F Youssef, Shivananda B Nayak
Jasmine flowers and leaves are used extensively in folk medicine in different parts of the world to treat a variety of diseases. However, there are very few published reports on the neuropsychiatric effects of Jasmine extracts. Hence, the objectives of the present study were to examine the effects of an alcohol extract of Jasminum multiflorum leaves on topically-applied bicuculline (a model of acute simple partial epilepsy) and maximal electroshock (MES, a model of generalized tonic-clonic seizure) in male Sprague-Dawley rats...
February 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28242476/an-investigation-of-the-characteristics-of-outpatients-with-epilepsy-and-antiepileptic-drug-utilization-in-a-multicenter-cross-sectional-study-in-china
#6
Peimin Yu, Dong Zhou, Weiping Liao, Xin Wang, Yuping Wang, Tiancheng Wang, Yuan Wu, Senyang Lang, Weihong Lin, Yijun Song, Heqing Zhao, Meng Cai, Zhen Hong
OBJECTIVES: This study aimed to describe the distribution of seizure types, clinical characteristics, and antiepileptic drug (AED) utilization in patients with epilepsy visiting tertiary hospitals in China. METHODS: This was an observational, cross-sectional epidemiology study conducted at 11 tertiary hospitals across China from May 2014 to November 2014. A total of 1603 patients, of either sex or any age with confirmed diagnosis of epilepsy, visiting outpatient clinics at tertiary hospitals were screened and enrolled...
February 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28239781/validation-of-the-promis-%C3%A2-measures-of-self-efficacy-for-managing-chronic-conditions
#7
Ann L Gruber-Baldini, Craig Velozo, Sergio Romero, Lisa M Shulman
PURPOSE: The Patient-Reported Outcomes Measurement Information System(®) (PROMIS(®)) was designed to develop, validate, and standardize item banks to measure key domains of physical, mental, and social health in chronic conditions. This paper reports the calibration and validation testing of the PROMIS Self-Efficacy for Managing Chronic Conditions measures. METHODS: PROMIS Self-Efficacy for Managing Chronic Conditions item banks comprise five domains, Self-Efficacy for Managing: Daily Activities, Symptoms, Medications and Treatments, Emotions, and Social Interactions...
February 26, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28222341/patient-emotions-and-perceptions-of-antiepileptic-drug-changes-and-titration-during-treatment-for-epilepsy
#8
Jesse Fishman, Greg Cohen, Colin Josephson, Ann Marie Collier, Srikanth Bharatham, Ying Zhang, Imane Wild
OBJECTIVE: To investigate the impact of antiepileptic drug (AED) change and dose titration on the emotional well-being of patients with epilepsy. METHODS: Members of an online epilepsy community were invited to voluntarily participate in an online survey. The cross-sectional anonymous survey consisted of 31 multiple choice questions balanced in terms of variety and positivity/negativity of emotions concerning participants' most recent AED change. To substantiate survey results, spontaneous comments from epilepsy-related online forums and social media websites that mentioned participants' experiences with AED medication changes (termed passive listening statements) were analyzed and categorized by theme...
February 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28217440/rapidly-progressive-cognitive-impairment-with-neuropsychiatric-symptoms-as-the-initial-manifestation-of-status-epilepticus
#9
Jorge A Mutis, Jesús H Rodríguez, Mauricio O Nava-Mesa
The purpose of this article is to describe the clinical and electroencephalographic features of patients diagnosed with non-convulsive status epilepticus (NCSE) with uncommon cognitive and behavioral involvement. We present two cases with sub-acute cognitive impairment and neuropsychiatric disorders (including anxiety and transient behavioral changes) as their first manifestation of NCSE. A neuropsychological profile demonstrated executive dysfunction. In addition, the neurological examination revealed automatisms and 24-hour video EEG showed epileptiform activity...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28199920/family-burden-child-disability-and-the-adjustment-of-mothers-caring-for-children-with-epilepsy-role-of-social-support-and-coping
#10
Jeffrey M Carlson, Paul A Miller
PURPOSE: This study was designed to contribute to the existing research on the coping behaviors, social support, and mental health outcomes in parents of children with epilepsy in the United States. METHODS: Participants included 152, predominantly Caucasian (89.5%), married (78.9%) women (95.4%). Via a web-based interface, mothers completed questionnaires assessing the impact of their child's disability on their family (i.e., severity of their child's disability, family burden, and personal stress), social resources (i...
February 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28188045/treatment-issues-for-children-with-epilepsy-transitioning-to-adult-care
#11
REVIEW
Rima Nabbout, Carol S Camfield, Danielle M Andrade, Alexis Arzimanoglou, Catherine Chiron, Joyce A Cramer, Jacqueline A French, Eric Kossoff, Marco Mula, Peter R Camfield
This is the third of three papers that summarize the second symposium on Transition in Epilepsies held in Paris in June 2016. This paper focuses on treatment issues that arise during the course of childhood epilepsy and make the process of transition to adult care more complicated. Some AEDs used during childhood, such as stiripentol, vigabatrin, and cannabidiol, are unfamiliar to adult epilepsy specialists. In addition, new drugs are being developed for treatment of specific childhood onset epilepsy syndromes and have no indication yet for adults...
February 7, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28178434/fever-phobia-as-a-reason-for-pediatric-emergency-department-visits-does-the-primary-care-physician-make-a-difference
#12
Erella Elkon-Tamir, Ayelet Rimon, Dennis Scolnik, Miguel Glatstein
BACKGROUND: Fever is a source of considerable parental anxiety. Numerous studies have also confirmed similar anxiety among health care workers. This study analyzed caregiver knowledge of fever, and beliefs concerning children with a febrile illness, with an emphasis on the referring physician. METHODS: This was a cross-sectional study of 100 caregivers of children 3 months to 12 years old, treated at an urban tertiary care pediatric emergency department for fever...
January 30, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28173780/protocol-for-the-encode-trial-evaluating-a-novel-online-depression-intervention-for-persons-with-epilepsy
#13
Björn Meyer, Mario Weiss, Martin Holtkamp, Stephan Arnold, Katja Brückner, Johanna Schröder, Franziska Scheibe, Yvonne Nestoriuc
BACKGROUND: Depression is common among persons with epilepsy (PwE), affecting roughly one in three individuals, and its presence is associated with personal suffering, impaired quality of life, and worse prognosis. Despite the availability of effective treatments, depression is often overlooked and treated inadequately in PwE, in part because of assumed concerns over drug interactions or proconvulsant effects of antidepressants. Internet-administered psychological interventions might complement antidepressant medication or psychotherapy, and preliminary evidence suggests that they can be effective...
February 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28160687/social-attention-in-children-with-epilepsy
#14
Judith Lunn, Tim Donovan, Damien Litchfield, Charlie Lewis, Robert Davies, Trevor Crawford
Children with epilepsy may be vulnerable to impaired social attention given the increased risk of neurobehavioural comorbidities. Social attentional orienting and the potential modulatory role of attentional control on the perceptual processing of gaze and emotion cues have not been examined in childhood onset epilepsies. Social attention mechanisms were investigated in patients with epilepsy (n=25) aged 8-18years old and performance compared to healthy controls (n=30). Dynamic gaze and emotion facial stimuli were integrated into an antisaccade eye-tracking paradigm...
April 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28157749/arterial-ischemic-stroke-in-children-and-young-adults
#15
Warren D Lo, Riten Kumar
PURPOSE OF REVIEW: This article reviews risk factors, recurrence risk, evaluation, management, and outcomes of arterial ischemic stroke in children and young adults. RECENT FINDINGS: The risk for recurrence and mortality appear to be low for neonatal and childhood stroke. Most children have relatively mild deficits, but those who have greater neurologic deficits, poststroke epilepsy, or strokes early in life are at risk for lower overall cognitive function. Stroke recurrence and long-term mortality after stroke in young adults are greater than originally thought...
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28157720/depression-in-epilepsy
#16
Marco Mula
PURPOSE OF REVIEW: To review some aspects of the relationship between epilepsy and depression that have recently received increasing attention and may become major research topics in the near future. RECENT FINDINGS: Epidemiological studies show that depression and suicide are, in some cases, premorbid symptoms preceding the onset of the epilepsy. Suicide is also three times more frequent in epilepsy than in the general population. Reliable screening instruments for depression and suicidality in patients with epilepsy are now available but data from real life clinical settings are needed to develop shared clinical pathways between neurology and psychiatry...
April 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28142130/the-relationship-of-seizure-focus-with-depression-anxiety-and-health-related-quality-of-life-in-children-and-adolescents-with-epilepsy
#17
William A Schraegle, Jeffrey B Titus
For youth with epilepsy, comorbid psychiatric conditions, such as depression and anxiety, require further examination as they carry increased risk for reduced health-related quality of life (HRQOL). The current study assessed whether rates of depression, anxiety, and withdrawal behaviors differed based on seizure location. Data included parental ratings on the Behavior Assessment System for Children (BASC-2) and the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 132 children and adolescents (mean age=11...
January 28, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28142129/effects-of-surgical-side-and-site-on-psychological-symptoms-following-epilepsy-surgery-in-adults
#18
Brigid E Prayson, Darlene P Floden, Lisa Ferguson, Kevin H Kim, Lara Jehi, Robyn M Busch
This retrospective study examined the potential role of side and site of surgery in psychological symptom change after epilepsy surgery and determined the base rate of psychological change at the individual level. Two-hundred twenty-eight adults completed the Personality Assessment Inventory (PAI) before and after temporal (TLR; n=190) or frontal lobe resection (FLR; n=38). Repeated measures ANOVAs with bootstrapping examined differences in psychological outcome as a function of surgical site separately in patients who underwent left- versus right-sided resections...
January 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28135595/genetic-background-contributes-to-the-co-morbidity-of-anxiety-and-depression-with-audiogenic-seizure-propensity-and-responses-to-fluoxetine-treatment
#19
Karine Yu Sarkisova, Irina B Fedotova, Natalia M Surina, Georgy M Nikolaev, Olga V Perepelkina, Zoya A Kostina, Inga I Poletaeva
BACKGROUND: Anxiety and depression are the most frequent comorbidities of different types of convulsive and non-convulsive epilepsies. Increased anxiety and depression-like phenotype have been described in the genetic absence epilepsy models as well as in models of limbic epilepsy and acquired seizure models, suggesting a neurobiological connection. However, whether anxiety and/or depression are comorbid to audiogenic epilepsy remains unclear. The aim of this study was to investigate whether anxiety or depression-like behavior can be found in rat strains with different susceptibility to audiogenic seizures (AS) and whether chronic fluoxetine treatment affects this co-morbidity...
January 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28115172/protective-effects-of-gabapentin-against-the-seizure-susceptibility-and-comorbid-behavioral-abnormalities-in-the-early-socially-isolated-mice
#20
Shayan Amiri, Arya Haj-Mirzaian, Hossein Amini-Khoei, Ali Razmi, Armin Shirzadian, Maryam Rahimi-Balaei, Carl O Olson, Arman Mohsenzadeh, Mojgan Rastegar, Mohammad-Reza Zarrindast, Mahmoud Ghazi-Khansari
Adolescence is a pivotal period of brain development during lifespan, which is sensitive to stress exposure. Early social isolation stress (SIS) is known to provoke a variety of psychiatric comorbidities as well as seizure risk. Psychiatric comorbidities present challenging dilemmas for treatment and management in people with seizure disorders. In this study, we aimed to investigate whether gabapentin (GBP) as an anti-epileptic drug is able to alleviate the seizure activity as well as comorbid behavioral abnormalities in socially isolated mice...
January 21, 2017: European Journal of Pharmacology
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