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Jeffrey Gordon

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https://www.readbyqxmd.com/read/29102480/what-are-the-key-elements-for-implementing-intensive-primary-care-a-multisite-veterans-health-administration-case-study
#1
Evelyn T Chang, Pushpa V Raja, Susan E Stockdale, Marian L Katz, Donna M Zulman, Jessica A Eng, Kathy H Hedrick, Jeffrey L Jackson, Neha Pathak, Brook Watts, Carrie Patton, Gordon Schectman, Steven M Asch
Many integrated health systems and accountable care organizations have turned to intensive primary care programs to improve quality of care and reduce costs for high-need high-cost patients. How best to implement such programs remains an active area of discussion. In 2014, the Veterans Health Administration (VHA) implemented five distinct intensive primary care programs as part of a demonstration project that targeted Veterans at the highest risk for hospitalization. We found that programs evolved over time, eventually converging on the implementation of the following elements: 1) an interdisciplinary care team, 2) chronic disease management, 3) comprehensive patient assessment and evaluation, 4) care and case management, 5) transitional care support, 6) preventive home visits, 7) pharmaceutical services, 8) chronic disease self-management, 9) caregiver support services, 10) health coaching, and 11) advanced care planning...
October 25, 2017: Healthcare
https://www.readbyqxmd.com/read/29097016/volumetric-mri-analysis-of-plexiform-neurofibromas-in-neurofibromatosis-type-1-comparison-of-two-methods
#2
Wenli Cai, Seth M Steinberg, Miriam A Bredella, Gina Basinsky, Bhanusupriya Somarouthu, Scott R Plotkin, Jeffrey Solomon, Brigitte C Widemann, Gordon J Harris, Eva Dombi
OBJECTIVES: Plexiform neurofibromas (PNs) are complex, histologically benign peripheral nerve sheath tumors that are challenging to measure by simple line measurements. Computer-aided volumetric segmentation of PN has become the recommended method to assess response in clinical trials directed at PN. Different methods for volumetric analysis of PN have been developed. The goal of this study is to test the level of agreement in volume measurements and in interval changes using two separate methods of volumetric magnetic resonance imaging analysis...
October 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29073107/spatial-organization-of-a-model-15-member-human-gut-microbiota-established-in-gnotobiotic-mice
#3
Jessica L Mark Welch, Yuko Hasegawa, Nathan P McNulty, Jeffrey I Gordon, Gary G Borisy
Knowledge of the spatial organization of the gut microbiota is important for understanding the physical and molecular interactions among its members. These interactions are thought to influence microbial succession, community stability, syntrophic relationships, and resiliency in the face of perturbations. The complexity and dynamism of the gut microbiota pose considerable challenges for quantitative analysis of its spatial organization. Here, we illustrate an approach for addressing this challenge, using (i) a model, defined 15-member consortium of phylogenetically diverse, sequenced human gut bacterial strains introduced into adult gnotobiotic mice fed a polysaccharide-rich diet, and (ii) in situ hybridization and spectral imaging analysis methods that allow simultaneous detection of multiple bacterial strains at multiple spatial scales...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29066370/factors-associated-with-prevalence-and-treatment-of-primary-biliary-cholangitis-in-united-states-health-systems
#4
Mei Lu, Jia Li, Irina V Haller, Robert J Romanelli, Jeffrey J VanWormer, Carla V Rodriguez, Marsha A Raebel, Joseph A Boscarino, Mark A Schmidt, Yihe G Daida, Amandeep Sahota, Jennifer Vincent, Christopher L Bowlus, Keith Lindor, Loralee B Rupp, Stuart C Gordon
BACKGROUND & AIMS: Reported prevalence of primary biliary cholangitis (PBC) varies widely. Demographic features and treatment patterns are not well characterized in the United States (US). We analyzed data from the Fibrotic Liver Disease (FOLD) consortium, from 11 geographically diverse health systems, to investigate epidemiologic factors and treatment of PBC in the US. METHODS: We developed a validated electronic health record-based classification model to identify patients with PBC in the FOLD consortium database, from 2003 through 2014...
October 21, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29064867/why-professional-football-players-chose-not-to-reveal-their-concussion-symptoms-during-a-practice-or-game
#5
Jeffrey Scott Delaney, Jeffrey G Caron, José A Correa, Gordon A Bloom
OBJECTIVE: To determine why professional football players in Canada decided not to seek medical attention during a game or practice when they believed they had suffered a concussion. DESIGN: Retrospective survey. SETTING: Preseason Canadian Football League training camps. PARTICIPANTS: Four hundred fifty-four male professional football players. MAIN OUTCOME MEASURES: Reasons athletes did not seek medical attention for a presumed concussion during the previous season, how often this occurred and how important these reasons were in the decision process...
October 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29056597/are-athletes-psychologically-ready-for-sport-following-a-concussion
#6
EDITORIAL
Jeffrey G Caron, Gordon A Bloom, Leslie W Podlog
No abstract text is available yet for this article.
October 22, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29053242/environmental-effects-on-zirconium-hydroxide-nanoparticles-and-chemical-warfare-agent-decomposition-implications-of-atmospheric-water-and-carbon-dioxide
#7
Robert B Balow, Jeffrey G Lundin, Grant C Daniels, Wesley O Gordon, Monica McEntee, Gregory W Peterson, James H Wynne, Pehr E Pehrsson
Zirconium hydroxide (Zr(OH)4) has excellent sorption properties and wide-ranging reactivity toward numerous types of chemical warfare agents (CWAs) and toxic industrial chemicals. Under pristine laboratory conditions, the effectiveness of Zr(OH)4 has been attributed to a combination of diverse surface hydroxyl species and defects; however, atmospheric components (e.g., CO2, H2O, etc.) and trace contaminants can form adsorbates with potentially detrimental impact to the chemical reactivity of Zr(OH)4. Here, we report the hydrolysis of a CWA simulant, dimethyl methylphosphonate (DMMP) on Zr(OH)4 determined by gas chromatography-mass spectrometry and in situ attenuated total reflectance Fourier transform infrared spectroscopy under ambient conditions...
October 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29038027/tumor-necrosis-factor-alpha-and-soluble-tnf-alpha-receptor-responses-in-young-vs-middle-aged-males-following-eccentric-exercise
#8
Eliott Arroyo, Adam J Wells, Joseph A Gordon, Alyssa N Varanoske, Yftach Gepner, Nicholas A Coker, David D Church, David H Fukuda, Jeffrey R Stout, Jay R Hoffman
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) has been shown to be implicated in both muscle regeneration and muscle wasting. However, it remains unclear whether TNF-α is responsible for the age-related losses in muscle size and function. Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) may provide a better indication of inflammatory events. The aim of this study was to examine changes in circulating concentrations of TNF-α, STNFR1, and STNFR2 following acute eccentric exercise in young (YA) and middle-aged (MA) men...
October 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29035695/expression-of-macrophage-genes-within-skeletal-muscle-correlates-inversely-with-adiposity-and-insulin-resistance-in-humans
#9
Dongmei Liu, Flor Elisa Morales, Heidi B IglayReger, Mary K Treutelaar, Amy E Rothberg, Monica J Hubal, Evan P Nadler, Jacques Robidoux, Hisham Barakat, Jeffrey F Horowitz, Eric P Hoffman, Charles F Burant, Paul M Gordon
Background Local inflammation in obese adipose tissue has been shown to contribute to insulin resistance, however, the role of macrophage infiltration within skeletal muscle is still debateable. This study aimed to evaluate the association of skeletal muscle macrophage gene expression with adiposity levels and insulin sensitivity in obese patients. Methods Twenty-two non-diabetic obese patients and 23 healthy lean controls were included. Obese patients underwent a 3-month weight loss intervention. Macrophage gene expression in skeletal muscle (quantitative RT-PCR), body composition (DXA) and insulin sensitivity (homeostatic model assessment and oral glucose tolerance test) were compared between groups and their associations were analyzed...
October 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29021918/protection-of-calves-by-a-prefusion-stabilized-bovine-rsv-f-vaccine
#10
Baoshan Zhang, Lei Chen, Chiara Silacci, Michelle Thom, Jeffrey C Boyington, Aliaksandr Druz, M Gordon Joyce, Efrain Guzman, Wing-Pui Kong, Yen-Ting Lai, Guillaume B E Stewart-Jones, Yaroslav Tsybovsky, Yongping Yang, Tongqing Zhou, Ulrich Baxa, John R Mascola, Davide Corti, Antonio Lanzavecchia, Geraldine Taylor, Peter D Kwong
Bovine respiratory syncytial virus, a major cause of respiratory disease in calves, is closely related to human RSV, a leading cause of respiratory disease in infants. Recently, promising human RSV-vaccine candidates have been engineered that stabilize the metastable fusion (F) glycoprotein in its prefusion state; however, the absence of a relevant animal model for human RSV has complicated assessment of these vaccine candidates. Here, we use a combination of structure-based design, antigenic characterization, and X-ray crystallography to translate human RSV F stabilization into the bovine context...
March 8, 2017: NPJ Vaccines
https://www.readbyqxmd.com/read/29019859/outcomes-after-phalloplasty-do-transgender-patients-and-multiple-urethral-procedures-carry-a-higher-rate-of-complication
#11
Austin C Remington, Shane D Morrison, Jonathan P Massie, Christopher S Crowe, Afaaf Shakir, Stelios C Wilson, Krishna S Vyas, Gordon K Lee, Jeffrey B Friedrich
INTRODUCTION: Phalloplasty is associated with improved quality-of-life in those with penile defects, and in female-to-male transgender (transmale) patients seeking gender-confirming surgery. However, aggregate complication and outcome data is sparse. This study compares phalloplasty outcomes between transmale and cismale patients and between those with primary versus staged urethroplasty. METHODS: A comprehensive literature search of PubMed, MEDLINE, and Google Scholar databases was conducted for studies relating to phalloplasty...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28980204/mechanistic-fluid-transport-model-to-estimate-gastrointestinal-fluid-volume-and-its-dynamic-change-over-time
#12
Alex Yu, Trachette Jackson, Yasuhiro Tsume, Mark Koenigsknecht, Jeffrey Wysocki, Luca Marciani, Gordon L Amidon, Ann Frances, Jason R Baker, William Hasler, Bo Wen, Amit Pai, Duxin Sun
Gastrointestinal (GI) fluid volume and its dynamic change are integral to study drug disintegration, dissolution, transit, and absorption. However, key questions regarding the local volume and its absorption, secretion, and transit remain unanswered. The dynamic fluid compartment absorption and transit (DFCAT) model is proposed to estimate in vivo GI volume and GI fluid transport based on magnetic resonance imaging (MRI) quantified fluid volume. The model was validated using GI local concentration of phenol red in human GI tract, which was directly measured by human GI intubation study after oral dosing of non-absorbable phenol red...
November 2017: AAPS Journal
https://www.readbyqxmd.com/read/28967836/creating-and-sustaining-a-culture-of-excellence-insights-from-accomplished-university-team-sport-coaches
#13
Daniela Donoso-Morales, Gordon A Bloom, Jeffrey G Caron
PURPOSE: Winning several national championships is an extraordinary feat that very few university coaches have accomplished. The objective of this study was to investigate how some of Canada's most accomplished university team-sport coaches created and sustained a culture of excellence in their programs. METHOD: Six university coaches who had won more than 30 national titles participated in this study. Each coach participated in a semistructured interview, and the qualitative data were inductively analyzed using a thematic analysis...
October 2, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28953887/pak-signalling-drives-acquired-drug-resistance-to-mapk-inhibitors-in-braf-mutant-melanomas
#14
Hezhe Lu, Shujing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T Frederick, Yi Hu, Wenqun Zhong, Sergio Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence W Wu, Jie Zhang, Xiaoming Liu, Wei Xu, Clemens Krepler, Katrin Sproesser, Min Xiao, Benchun Miao, Jianglan Liu, Claire D Song, Jephrey Y Liu, Giorgos C Karakousis, Lynn M Schuchter, Yiling Lu, Gordon Mills, Yusheng Cong, Jonathan Chernoff, Jun Guo, Genevieve M Boland, Ryan J Sullivan, Zhi Wei, Jeffrey Field, Ravi K Amaravadi, Keith T Flaherty, Meenhard Herlyn, Xiaowei Xu, Wei Guo
Targeted BRAF inhibition (BRAFi) and combined BRAF and MEK inhibition (BRAFi and MEKi) therapies have markedly improved the clinical outcomes of patients with metastatic melanoma. Unfortunately, the efficacy of these treatments is often countered by the acquisition of drug resistance. Here we investigated the molecular mechanisms that underlie acquired resistance to BRAFi and to the combined therapy. Consistent with previous studies, we show that resistance to BRAFi is mediated by ERK pathway reactivation. Resistance to the combined therapy, however, is mediated by mechanisms independent of reactivation of ERK in many resistant cell lines and clinical samples...
October 5, 2017: Nature
https://www.readbyqxmd.com/read/28939823/stapled-peptide-inhibitors-of-rab25-target-context-specific-phenotypes-in-cancer
#15
Shreya Mitra, Jeffrey E Montgomery, Matthew J Kolar, Gang Li, Kang J Jeong, Bo Peng, Gregory L Verdine, Gordon B Mills, Raymond E Moellering
Recent evidence has established a role for the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and anti-oncogenic phenotypes in specific cellular contexts. Here we report the development of all-hydrocarbon stabilized peptides derived from the RAB-binding FIP-family of proteins to target RAB25. Relative to unmodified peptides, optimized stapled peptides exhibit increased structural stability, binding affinity, cell permeability, and inhibition of RAB25:FIP complex formation...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28936799/proteomic-features-of-colorectal-cancer-identify-tumor-subtypes-independent-of-oncogenic-mutations-and-independently-predict-relapse-free-survival
#16
Callisia N Clarke, Michael S Lee, Wei Wei, Ganiraju Manyam, Zhi-Qin Jiang, Yiling Lu, Jeffrey Morris, Bradley Broom, David Menter, Eduardo Vilar-Sanchez, Kanwal Raghav, Cathy Eng, George J Chang, Iris Simon, Rene Bernards, Michael Overman, Gordon B Mills, Dipen Maru, Scott Kopetz
BACKGROUND: The directed study of the functional proteome in colorectal cancer (CRC) has identified critical protein markers and signaling pathways; however, the prognostic relevance of many of these proteins remains unclear. METHODS: We determined the prognostic implications of the functional proteome in 263 CRC tumor samples from patients treated at MD Anderson Cancer Center (MDACC) and 462 patients from The Cancer Genome Atlas (TCGA) to identify patterns of protein expression that drive tumorigenesis...
December 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28935908/biometric-monitoring-devices-for-assessing-end-points-in-clinical-trials-developing-an-ecosystem
#17
Stephen P Arnerić, Jesse M Cedarbaum, Sean Khozin, Spyros Papapetropoulos, Derek L Hill, Michael Ropacki, Jane Rhodes, Penny A Dacks, Lynn D Hudson, Mark Forrest Gordon, Volker D Kern, Klaus Romero, George Vradenburg, Rhoda Au, Daniel R Karlin, Maurizio F Facheris, Cheryl J Fitzer-Attas, Ottavio V Vitolo, Jian Wang, Bradley M Miller, Jeffrey A Kaye
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28904197/differential-inhibitory-receptor-expression-on-t-cells-delineates-functional-capacities-in-chronic-viral-infection
#18
Jeffrey E Teigler, Gennadiy Zelinskyy, Michael A Eller, Diane L Bolton, Mary Marovich, Alexander D Gordon, Aljawharah Alrubayyi, Galit Alter, Merlin L Robb, Jeffrey N Martin, Steven G Deeks, Nelson L Michael, Ulf Dittmer, Hendrik Streeck
Inhibitory receptors have been extensively described for their importance in regulating immune responses in chronic infections and cancers. Blocking the function of inhibitory receptors such as PD-1, CTLA-4, 2B4, Tim-3, and LAG-3 has shown promise for augmenting CD8 T cell activity and boosting pathogen-specific immunity. However, the prevalence of inhibitory receptors on CD4 T cells and their relative influence on CD4 T cell functionality in chronic HIV infection remains poorly described. We therefore determined and compared inhibitory receptor expression patterns of 2B4, CTLA-4, LAG-3, PD-1, and Tim-3 on virus-specific CD4 and CD8 T cells in relation to their functional T cell profile...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28899863/a-unified-approach-to-targeting-the-lysosome-s-degradative-and-growth-signaling-roles
#19
Vito W Rebecca, Michael C Nicastri, Noel McLaughlin, Colin Fennelly, Quentin McAfee, Amruta Ronghe, Michel Nofal, Chun-Yan Lim, Eric Witze, Cynthia I Chude, Gao Zhang, Gretchen M Alicea, Shengfu Piao, Sengottuvelan Murugan, Rani Ojha, Samuel M Levi, Zhi Wei, Julie S Barber-Rotenberg, Maureen E Murphy, Gordon B Mills, Yiling Lu, Joshua Rabinowitz, Ronen Marmorstein, Qin Liu, Shujing Liu, Xiaowei Xu, Meenhard Herlyn, Roberto Zoncu, Donita C Brady, David W Speicher, Jeffrey D Winkler, Ravi K Amaravadi
Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as chloroquine or quinacrine have been used as lysosomal inhibitors, but fail to inhibit mTOR signaling. Further, the molecular target of these agents has not been identified. We report a screen of novel dimeric antimalarials that identifies dimeric quinacrines (DQ) as potent anticancer compounds, which concurrently inhibit mTOR and autophagy...
November 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28899096/physical-rheological-functional-and-film-properties-of-a-novel-emulsifier-frost-grape-polysaccharide-from-vitis-riparia-michx
#20
William T Hay, Steven F Vaughn, Jeffrey A Byars, Gordon W Selling, Derek M Holthaus, Neil P J Price
A novel emulsifier, Frost grape polysaccharide (FGP), isolated from natural exudate of the species Vitis riparia Michx, was physically and rheologically characterized. The determination of the physical, structural, thermodynamic, emulsification, film, and rheological properties of FGP provide essential details for the commercial adoption of this novel plant polysaccharide. FGP is capable of producing exceptionally stable emulsions when compared with the industrially ubiquitous gum arabic (GA). The FGP isolate contained a negligible amount of nitrogen (0...
September 25, 2017: Journal of Agricultural and Food Chemistry
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