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https://www.readbyqxmd.com/read/28522905/strategies-used-by-helicobacter-pylori-to-establish-persistent-infection
#1
REVIEW
Amin Talebi Bezmin Abadi
Helicobacter pylori (H. pylori) is a Gram-negative and motile bacterium that colonizes the hostile microniche of the human stomach, then persists for the host's entire life, if not effectively treated. Clinically, H. pylori plays a causative role in the development of a wide spectrum of diseases including chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Due to the global distribution of H. pylori, it is no exaggeration to conclude that smart strategies are contributing to adaptation of the bacterium to its permanent host...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28522781/laparoscopic-gastric-resections-with-per-oral-specimen-extraction-in-treatment-of-intramural-gastric-tumors
#2
Maciej Stanek, Piotr Major, Mateusz Wierdak, Michał Pędziwiatr, Dorota Radkowiak, Anna Zychowicz, Andrzej Budzyński
AIM: The goal of this work was to present our experiences and results of treatment of gastric tumors using the per oral specimen extraction (POSE) technique. MATERIAL AND METHODS: A retrospective analysis a group of patients treated with laparoscopic stomach wedge resection of gastrointestinal stromal tumor (GIST). During that time 50 patients underwent laparoscopy due to the suspicion of GIST. In 12 patients resected material was removed endoscopically per os (POSE)...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28522324/non-invasive-three-dimensional-imaging-of-escherichia-coli-k1-infection-using-diffuse-light-imaging-tomography-combined-with-micro-computed-tomography
#3
REVIEW
Luci A Witcomb, Julie Czupryna, Kevin P Francis, Gad Frankel, Peter W Taylor
In contrast to two-dimensional bioluminescence imaging, three dimensional diffuse light imaging tomography with integrated micro-computed tomography (DLIT-μCT) has the potential to realise spatial variations in infection patterns when imaging experimental animals dosed with derivatives of virulent bacteria carrying bioluminescent reporter genes such as the lux operon from the bacterium Photorhabdus luminescens. The method provides an opportunity to precisely localise the bacterial infection sites within the animal and enables the generation of four-dimensional movies of the infection cycle...
May 15, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28508421/subversion-of-host-kinases-a-key-network-in-cellular-signaling-hijacked-by-helicobacter-pylori-caga
#4
REVIEW
Nicole Tegtmeyer, Matthias Neddermann, Carmen Isabell Asche, Steffen Backert
Helicobacter pylori is a paradigm of persistent pathogens and major risk factor for developing severe diseases including adenocarcinoma in the human stomach. An important bacterial factor linked to gastric disease progression is the cag pathogenicity island-encoded type-IV secretion system (T4SS) effector protein CagA. Translocated CagA undergoes tyrosine phosphorylation at EPIYA-motifs and then activates or inactivates multiple host signaling proteins in a phosphorylation-dependent and phosphorylation-independent fashion...
May 15, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28505287/anti-helicobacter-pylori-activity-of-non-living-heat-killed-form-of-lactobacilli-including-lactobacillus-johnsonii-no-1088
#5
Yuji Aiba, Hiroki Ishikawa, Masayoshi Tokunaga, Yasuhiko Komatsu
Some strains of lactic acid bacteria are reported to inhibit the growth of Helicobacter pylori (H. pylori) and proposed to be useful to support so-called triple therapy for H. pylori. Although most strains must be alive to exert their anti-H. pylori activity, some lactobacilli strains are effective even when dead. One possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with H. pylori. In the present study, we found that a non-living heat-killed form of Lactobacillus johnsonii No...
May 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28504579/exopolysaccharide-producing-streptococcus-thermophilus-crl1190-reduces-the-inflammatory-response-caused-by-helicobacter-pylori
#6
G Marcial, J Villena, G Faller, A Hensel, G Font de Valdéz
This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28499377/calculating-hospital-length-of-stay-using-the-hospital-episode-statistics-a-comparison-of-methodologies
#7
John Busby, Sarah Purdy, William Hollingworth
BACKGROUND: Accurate calculation of hospital length of stay (LOS) from the English Hospital Episode Statistics (HES) is important for a wide range of audit and research purposes. The two methodologies which are commonly used to achieve this differ in their accuracy and complexity. We compare these methods and make recommendations on when each is most appropriate. METHODS: We calculated LOS using continuous inpatient spells (CIPS), which link care spanning across multiple hospitals, and spells, which do not, for six conditions with short (dyspepsia or other stomach function, ENT infection), medium (dehydration and gastroenteritis, perforated or bleeding ulcer), and long (stroke, fractured proximal femur) average LOS...
May 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28493185/dietary-pufa-increase-apoptosis-in-stomach-of-patients-with-dyspeptic-symptoms-and-infected-with-h-pylori
#8
Rasoul Sharifi, Mohammad Nouri, Akram Eidi, Zahra Noormohammadi, Homayun Dolatkhah, Masoud Shirmohammadi
Drug-resistant strains of Helicobacter pylori and poor treatment response are the main reasons for the failure in eradicating it in patients. Polyunsaturated fatty acids (PUFA) have an inhibitory effect on bacterial growth. The aim of this study was to investigate the effect of PUFA in combination with standard triple therapy on apoptosis in H. pylori infected subjects with dyspeptic symptoms. This study was a double-blind clinical trial in which 34 H. pylori infected subjects with dyspeptic symptoms were randomly divided into two groups of 17 patients...
May 10, 2017: Lipids
https://www.readbyqxmd.com/read/28485344/plasmablastic-lymphoma-of-the-gastrointestinal-tract-a-rare-entity-with-a-dismal-prognosis
#9
A S Komaranchath, R A Haleshappa, L C Kuntegowdenahalli, R V Kumar, L Dasappa, G Babu
INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare and aggressive type of mature B-cell lymphoma, which is usually associated with HIV infection. The most common site of PBL is the oral cavity. Involvement of the gastrointestinal (GI) tract is rare, and literature is limited to few case reports and case series. AIMS: To retrospectively analyze the presentation, clinical findings, and outcome of patients presenting to our institute with a diagnosis of PBL involving the GI tract...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28482758/lesions-caused-by-virulent-aeromonas-hydrophila-in-farmed-catfish-ictalurus-punctatus-and-i-punctatus-%C3%A3-i-furcatus-in-mississippi
#10
Wes A Baumgartner, Lorelei Ford, Larry Hanson
In 2009, a virulent strain of Aeromonas hydrophila caused severe disease and high mortalities (motile aeromonad septicemia variant [MASv]) in farmed channel catfish ( Ictalurus punctatus) and hybrid catfish ( I. punctatus × I. furcatus) in eastern Mississippi and Alabama. As is common in MAS, there is severe hemorrhagic dermatitis with ulceration, as well as abdominal hyperemia, petechiation, and mild ascites. Additional findings in MASv cases include panophthalmitis and orbital cellulitis, leading to ocular rupture, and brains are often hyperemic with mild random acute hemorrhage...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28473011/description-and-genetic-characterization-of-a-new-contracaecum-larval-type-nematoda-anisakidae-from-australia
#11
S Shamsi, A Turner, S Wassens
Nematode parasites belonging to the genus Contracaecum are economically important parasites with zoonotic significance. Adult Contracaecum spp. are found in the stomach of marine mammals or piscivorous birds, and larval stages infect a wide range of invertebrates and fish species. Human infection with Contracaecum larvae has been reported in Australia and other countries after the consumption of infected fish. Although the genus Contracaecum comprises numerous species, thus far only four Contracaecum larval types have been specifically identified, therefore their life cycle and biology are not yet fully understood...
May 5, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28472501/secondary-graft-oesophageal-fistula-after-total-arch-replacement%C3%A2
#12
Ken Yamanaka, Norihiko Shiiya, Naoki Washiyama, Masanori Sato
Secondary graft-oesophageal fistula is a fatal complication of aortic arch replacement. We report a successful two-stage surgical management of a graft-oesophageal fistula seen in a 68-year-old woman 3 years after total aortic arch replacement. She presented with a prolonged intractable fever without haematemesis. The fistula occurred between the distal aortic anastomosis and oesophagus; the entire graft was surrounded by air. In the first-stage operation, we performed re-replacement of the entire infected graft, oesophagectomy with cervical oesophagostomy, omental transfer and cervical routing of the stomach roll, through an extended left thoracotomy incision with sternal transection...
May 2, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28471844/image-characteristics-and-classification-of-salivagram-in-the-diagnosis-of-pulmonary-aspiration-in-children
#13
Ha Wu, Ruifang Zhao
PURPOSE: A salivagram is a common method capable of detecting pulmonary aspiration. This investigation focused on describing the characteristics of salivagram and classifying the image to increase the clinical value of this imaging method. MATERIALS AND METHODS: A retrospective analysis was carried out of 428 patients (aged 1-36 months, mean age 4.5 months) diagnosed with respiratory tract infection and suspect pulmonary aspiration subjected to a salivagram, and the resulting images were classified on the basis of their features...
May 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28471561/effects-of-helicobacter-pylori-colonization-infection-on-the-metabolic-profile-of-obese-persons-undergoing-sleeve-gastrectomy-surgery-for-weight-reduction
#14
Mordechai Shimonov, Lior Leibou, Eduard Davidov, Olga Bernadsky, Julio Wainstein, Eyal Leibovitz
BACKGROUND: Helicobacter pylori (HP) infection of the gastric mucosa may be involved in the development of insulin resistance (IR). OBJECTIVES: To investigate the association between HP status in stomach biopsies and weight reduction in patients who underwent laparoscopic sleeve gastrectomy (LSG). METHODS: In this retrospective analysis of medical charts, all patients who underwent LSG for weight reduction and had at least 1 year of follow-up were included...
July 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28467057/conditional-chaperone-client-interactions-revealed-by-genetically-encoded-photo-cross-linkers
#15
Shuai Zhang, Dan He, Zhi Lin, Yi Yang, Haiping Song, Peng R Chen
The cell envelope is an integral and essential component of Gram-negative bacteria. As the front line during host-pathogen interactions, it is directly challenged by host immune responses as well as other harsh extracellular stimuli. The high permeability of the outer-membrane and the lack of ATP energy system render it difficult to maintain important biological activities within the periplasmic space under stress conditions. The HdeA/B chaperone machinery is the only known acid resistant system found in bacterial periplasm, enabling enteric pathogens to survive through the highly acidic human stomach and establish infections in the intestine...
May 3, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28462373/oxidative-stress-resulting-from-helicobacter-pylori-infection%C3%A2-contributes-to-gastric-carcinogenesis
#16
REVIEW
Lindsay D Butcher, Gerco den Hartog, Peter B Ernst, Sheila E Crowe
Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state with continued oxidative stress within the tissue. Reactive oxygen species and reactive nitrogen species produced by the immune and epithelial cells damage the host cells and can result in DNA damage. H pylori has evolved to evoke this damaging response while blunting the host's efforts to kill the bacteria...
May 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28455589/n-acetylcysteine-prevents-the-development-of-gastritis-induced-by-helicobacter-pylori-infection
#17
Sungil Jang, Eun-Jung Bak, Jeong-Heon Cha
Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evaluated the effect of NAC itself on the growth and colonization of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated in broth culture containing NAC...
May 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28454275/variations-in-the-multimerization-region-of-the-helicobacter-pylori-cytotoxin-caga-affect-virulence
#18
Daiva Ahire, Tricia Alston, Robert Raffaniello
Helicobacter pylori colonizes the human stomach by infecting gastric epithelial cells. It is the primary cause of peptic ulcer disease and gastric cancer (GC). Cytotoxin-associated gene A (CagA) is a virulence factor produced by H. pylori. Strains positive for the CagA protein are associated with more severe gastric diseases. The 3' region of the cagA gene exhibits heterogeneity with respect to tyrosine phosphorylation motifs (EPIYA) and CagA multimerization motifs (CM). CagA proteins are categorized as either Western or Eastern based on EPIYA sequences...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28436616/reduced-infectivity-of-waterborne-viable-but-nonculturable-helicobacter-pylori-strain-ss1-in-mice
#19
Kevin F Boehnke, Kathryn A Eaton, Clinton Fontaine, Rebecca Brewster, Jianfeng Wu, Joseph N S Eisenberg, Manuel Valdivieso, Laurence H Baker, Chuanwu Xi
BACKGROUND: Helicobacter pylori infection has been consistently associated with lack of access to clean water and proper sanitation, but no studies have demonstrated that the transmission of viable but nonculturable (VBNC) H. pylori can occur from drinking contaminated water. In this study, we used a laboratory mouse model to test whether waterborne VBNCH. pylori could cause gastric infection. MATERIALS AND METHODS: We performed five mouse experiments to assess the infectivity of VBNCH...
April 24, 2017: Helicobacter
https://www.readbyqxmd.com/read/28420890/endoscopic-manifestations-and-clinical-characteristics-of-cytomegalovirus-infection-in-the-upper-gastrointestinal-tract
#20
Masaya Iwamuro, Eisei Kondo, Takehiro Tanaka, Hideharu Hagiya, Seiji Kawano, Yoshiro Kawahara, Fumio Otsuka, Hiroyuki Okada
We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD)...
April 2017: Acta Medica Okayama
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