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https://www.readbyqxmd.com/read/28629725/relationship-between-histopathological-status-of-the-helicobacter-pylori-infected-patients-and-proteases-of-h-pylori-in-isolates-carrying-diverse-virulence-genotypes
#1
Somayyeh Gharibi, Tahereh Falsafi, Masoud Alebouyeh, Nastaran Farzi, Farzam Vaziri, Mohamad Reza Zali
Helicobacter pylori is the main cause of several gastroduodenal diseases in Humans. Among various virulence factors of H. pylori, proteases may also be involved in its pathogenicity. In this study, relationship between proteolytic activity of H. pylori strains and histopathological changes of the stomach was investigated in the patients infected with strains carrying diverse virulence factors. H. pylori strains were isolated from the biopsies of 116 patients who referred to hospital for their gastroduodenal disorders, in Tehran, Iran...
June 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28627493/parasitic-infections-in-the-east-asian-finless-porpoise-neophocaena-asiaeorientalis-sunameri-living-off-the-chinese-yellow-bohai-sea-coast
#2
X L Wan, J S Zheng, W X Li, X Y Zeng, J W Yang, Y J Hao, D Wang
Parasitic disease is among the major causes of health problems in marine mammals. However, little information on parasitic species composition and infection levels in finless porpoises (Neophocaena spp.) is available. In this study, we report the first systematic survey on parasitic infections in the East Asian finless porpoise N. asiaeorientalis sunameri (EAFP) living off the Chinese Yellow/Bohai Sea coast. Using both morphological and molecular methods, 5 parasitic helminths were identified: Campula oblonga in the liver and pancreas; Synthesium seymouri in the pyloric stomach and duodenum ampulla; Anisakis pegreffii in the forestomach, main stomach, and esophagus; Halocercus sp...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28626260/a-case-of-api2-malt1-positive-gastric-malt-lymphoma-with-concomitant-diffuse-large-b-cell-lymphoma
#3
Akashi Fujita, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Hiroshi Imaoka, Tsukasa Yoshida, Nozomi Okuno, Nobuhiro Hieda, Takashi Hirayama, Hitoshi Shibuya, Hisashi Kondo, Hirotaka Suzuki, Kazuhiro Toriyama, Yasushi Yatabe, Kenji Yamao, Yasumasa Niwa
API2-MALT1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma is thought to transform to diffuse large B-cell lymphoma (DLBCL) rarely. A 69-year-old man presented with epigastralgia. Esophagogastroduodenoscopy showed multiple ulcerations in the stomach. Endoscopic biopsies revealed MALT lymphoma, with Helicobacter pylori infection. The patient underwent eradication therapy with no improvement, and was thereafter followed without additional therapy at his request...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28625823/the-leukocyte-associated-immunoglobulin-ig-like-receptor-1-modulating-cell-apoptosis-and-inflammatory-cytokines-secretion-in-thp-1%C3%A2-cells-after-helicobacter-pylori-infection
#4
Ying Zhang, Hui Sun, Jiaojiao Li, Qianyu Rong, Xiaofei Ji, Boqing Li
OBJECTIVE: Helicobacter pylori is a Gram-negative, microaerophilic bacteria usually found in the stomach, which may evade its host's immune system and present long-term symptoms in affected individuals. This study aimed to evaluate the functional role of leukocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in the strategies and underlying molecular mechanisms by which H. pylori escapes the host's immune responses. METHODS: LAIR-1 knockdown THP-1 cells were used to detect cell apoptosis, cell proliferation, interleukin-8 (IL-8), IL-10, and activation of intracellular signaling induced by H...
June 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28624491/the-first-report-of-cathepsin-a-gene-in-a-teleost-rock-bream-oplegnathus-fasciatus-an-investigation-of-immune-functions-upon-infection-with-several-pathogens
#5
Ju-Won Kim, Hee Jeong Kong, Bo-Hye Nam, Jung Youn Park, Do-Hyung Kim, Ji-Min Jeong, Chan-Il Park
We isolated and characterised a cDNA encoding the lysosomal protective protein (serine protease) cathepsin A (CTSA) from rock bream (Oplegnathus fasciatus). The full-length rock bream CTSA (RbCTSA) cDNA (1814 bp) contains an open reading frame of 1419 bp that encodes 472 amino acids. Alignment of multiple CTSA protein sequences revealed that the active site serine and histidine residues were well-conserved among the other CTSA sequences. RbCTSA is highly expressed in the peripheral blood leukocytes, kidney, spleen, liver, intestine, gill, heart, brain, stomach, and eye...
June 14, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28624470/molecular-cloning-and-expression-analysis-of-ccl25-and-its-receptor-ccr9s-from-epinephelus-coioides-post-cryptocaryon-irritans-infection
#6
Man Yang, Ling Zhou, Hai-Qing Wang, Xiao-Chun Luo, Xue-Ming Dan, Yan-Wei Li
Among other functions, CCL25/CCR9 has an important role in regulating the trafficking of developing T cells in the thymus, and in homing memory T cells to the small intestine. The function of this chemokine-receptor complex is not well studied in fish. We identified a CCL25-like (EcCCL25, 108 aa) and two CCR9-like sequences (EcCCR9aa 373 aa; and EcCCR9b, 375 aa) from a transcriptome database of orange-spotted grouper (Epinephelus coioides). EcCCL25, EcCCR9a, and EcCCR9b shared conserved structural features with homologs from mammals and from other fish, and a consistent relationship with phylogenetic trees and sequence identities...
June 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28622424/migration-of-the-distal-catheter-of-the-ventriculoperitoneal-shunt-in-hydrocephalus-a-comprehensive-analytical-review-from-an-anatomical-perspective
#7
REVIEW
Mohammed Z Allouh, Mohammed M Al Barbarawi, Hasan A Asfour, Raed S Said
There have been many reports on migration of the distal catheter of the ventriculoperitoneal shunt (VPS) since this phenomenon was recognized 50 years ago. However, there have been no attempts to analyze its different patterns or to assess these patterns in terms of potential risk to patients. We comprehensively reviewed all reports of distal VPS catheter migration indexed in PubMed and identified three different anatomical patterns of migration based on catheter extension and organs involved: (1) internal, when the catheter invades any viscus inside the thoracic, abdominal, or pelvic cavity; (2) external, when the catheter penetrates through the body wall either incompletely (subcutaneously) or completely (outside the body); and (3) compound, when the catheter penetrates a hollow viscus and protrudes through a pre-existing anatomical orifice...
June 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28619227/efficacy-and-safety-of-praziquantel-in-preschool-aged-and-school-aged-children-infected-with-schistosoma-mansoni-a-randomised-controlled-parallel-group-dose-ranging-phase-2-trial
#8
Jean T Coulibaly, Gordana Panic, Kigbafori D Silué, Jana Kovač, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Praziquantel has been the drug of choice for schistosomiasis control for more than 40 years, yet surprisingly, the optimal dose for children younger than 4 years is not known. We aimed to assess the efficacy and safety of escalating praziquantel dosages in preschool-aged children (PSAC). METHODS: We did a randomised controlled, parallel-group, single-blind, dose-ranging, phase 2 trial in PSAC (2-5 years) and school-aged children (SAC; aged 6-15 years) as a comparator group in southern Côte d'Ivoire...
July 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28619040/helicobacter-suis-induces-changes-in-gastric-inflammation-and-acid-secretion-markers-in-pigs-of-different-ages
#9
C De Witte, B Devriendt, B Flahou, I Bosschem, R Ducatelle, A Smet, F Haesebrouck
Gastric mRNA expression of markers for acid secretion and inflammation and presence of gastric ulceration was studied in naturally Helicobacter suis-infected and non-infected 2-3 months old, 6-8 months old and adult pigs. In H. suis-infected 2-3 months old pigs, IL-8 and IL-1β transcript levels were upregulated in the pyloric gland zone, indicating an innate immune response. A similar response was demonstrated in the fundic gland zone of adult pigs, potentially due to a shift of H. suis colonization from the pyloric to the fundic gland zone...
June 15, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28616085/helicobacter-pylori-infection-old-and-new
#10
REVIEW
S Diaconu, A Predescu, A Moldoveanu, C S Pop, C Fierbințeanu-Braticevici
Helicobacter pylori is a spiral-shaped bacterium that grows in the digestive tract and may be present in more than half of the world's population. The clinical features of Helicobacter pylori range from asymptomatic gastritis to gastrointestinal malignancy. Mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B-cell marginal zone lymphoma and Helicobacter pylori has been detected in more than 75% of the patients with MALT lymphoma. Many tests for the detection of Helicobacter pylori are available, including antibody tests, urea breath tests, stool antigen tests and endoscopic biopsies...
April 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28606862/pathogenicity-profile-of-vibrio-parahaemolyticus-in-farmed-pacific-white-shrimp-penaeus-vannamei
#11
R Ananda Raja, R Sridhar, C Balachandran, A Palanisammi, S Ramesh, K Nagarajan
A pathobiological study was conducted using Vibrio parahaemolyticus (VP) strain isolated from vibriosis affected shrimp (Penaeus vannamei) farms in Kancheepuram and Thiruvallur districts of Tamil Nadu during August 2014 to February 2015. The isolate was identified based on the morphological, physiological, biochemical and molecular characters. LD50 value with intramuscular injection was determined as 2.6 × 10(4) cfu/shrimp and sequential pathology was studied giving 6.1 × 10(3) cfu/shrimp (LD25). Total plate count (TPC) and total Vibrio count (TVC) in water, pond sediment, haemolymph, muscle, HP and gut were found significantly (P < 0...
June 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28606318/integrative-taxonomy-of-goezia-spinulosa-nematoda-raphidascarididae-from-arapaimas-in-the-northwestern-brazil
#12
Maralina Torres da Silva, Pedro Hercílio de Oliveira Cavalcante, Ana Carolina Alves de Camargo, Vanessa Aparecida das Chagas Moutinho, Everton Gustavo Nunes Dos Santos, Cláudia Portes Santos
Arapaima gigas, a fish with a high market value, has been farmed in different localities within Brazil. Among its parasites, adults of Goezia spinulosa are reported to cause ulcers in the stomach and to result in the death of farmed fingerlings. Due to the veterinary importance of this nematode in cultured arapaimas, an integrative taxonomic study is proposed, combining morphological, ultrastructural and genetic profiles of this parasite. The fish were obtained from semi-intensive fish farming in Acre State, Brazil...
August 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28606081/isolation-of-anti-mycobacterial-compounds-from-curtisia-dentata-burm-f-c-a-sm-curtisiaceae
#13
Victor O Fadipe, Nkoana I Mongalo, Andy R Opoku, Preachers M Dikhoba, Tshepiso J Makhafola
BACKGROUND: Tuberculosis is counted amongst the most infectious and lethal illnesses worldwide and remains one of the major threats to human health. The aim of the current study was to isolate and characterize anti-mycobacterial compounds present in Curtisia dentata (Burm.f.) C.A.Sm , a medicinal plant reportedly used in the treatment of tuberculosis, stomach ailments and sexually transmitted infections. METHODS: The bioassay guided principle was followed to isolate the anti-mycobacterial compounds...
June 12, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28601524/rifampin-stability-and-solution-concentration-enhancement-through-amorphous-solid-dispersion-in-cellulose-%C3%AF-carboxyalkanoate-matrices
#14
Hale Çiğdem Arca, Laura I Mosquera-Giraldo, Junia M Pereira, Nammalwar Sriranganathan, Lynne S Taylor, Kevin J Edgar
Tuberculosis (TB) is a deadly infectious disease; approximately 2 billion people are currently latently infected with the causative agent Mycobacterium tuberculosis. Approximately 8 million new active cases and 2 million deaths due to TB are recorded annually(1). Rifampin (Rif) is a vital first line TB treatment drug. Its effectiveness is hampered by the high dose required (600 mg 1x/day) and by its moderate, variable bioavailability. These issues can be explained by Rif instability at gastric pH, limited solubility at neutral pH, polymorphism, and stimulation of its own metabolism...
June 7, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28598064/emphysematous-gastritis-with-air-in-portal-venous-system
#15
Omesh Goyal, Ajesh Bansal, Prerna Goyal
Emphysematous gastritis is a rare but severe form of phlegmonous gastritis caused by gastric mucosal disruption and infection of stomach wall by gas-forming bacteria. Ingestion of corrosive substances is the most common predisposing factor, followed by alcohol abuse, abdominal surgery, diabetes and immunosuppression. Patients usually present with abdominal pain, vomiting, diarrhea, constipation and/or gastro-intestinal hemorrhage. Characteristic radiological findings include presence of gas in the gastric wall...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28585591/current-status-of-helicobacter-pylori-association-with-haematological-and-cardiovascular-diseases-a-mini-review
#16
Jibran Sualeh Muhammad, Syed Faisal Zaidi, Sheikh Abdul Saeed, Muhammad Ishaq
Helicobacter pylori infection is considered the most commonly prevalent gastrointestinal pathogen where it manages to survive despite the hostile environment of human stomach, leading to various gastric diseases including gastric cancer. Due to the chronic inflammatory state induced by H. pylori and its interaction with host immune system have diverted researchers to investigate its correlation with systemic diseases outside of the gastrointestinal tract. This literature review was done to explore the association of H...
June 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28581361/the-study-of-h-pylori-putative-candidate-factors-for-single-and-multi-component-vaccine-development
#17
Nasrin Mirzaei, Farkhondeh Poursina, Sharareh Moghim, Niloufar Rashidi, Hajieh Ghasemian Safaei
Helicobacter pylori has grown to colonize inside the stomach of nearly half of the world's population, turning into the most prevalent infections in the universe. Medical care failures noticeably confirm the need for a vaccine to hinder or deal with H. pylori. This review is planned to discuss the most known factors as a vaccine candidate, including single (AhpC, BG, CagA, KatA, Fla, Hsp, HWC, Lpp, LPS, NAP, OMP, OMV, SOD, Tpx, Urease, VacA) and multi-component vaccines. Many promising results in the field of single and multivalent vaccine can be seen, but there is no satisfactory outcome and neither a prophylactic nor a therapeutic vaccine to treat or eradicate the infection in human has been acquired...
September 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28577915/histo-blood-group-carbohydrates-as-facilitators-for-infection-by-helicobacter-pylori
#18
REVIEW
Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos
Helicobacter pylori infect millions of people around the world. It occupies a niche in the human gastrointestinal tract characterized by high expression of a repertoire of carbohydrates. ABO and Lewis histo-blood group systems are controlled by genes coding for functional glycosyltransferases which synthesize great diversity of related fucosylated carbohydrate in different tissues, including gastrointestinal mucosa, and exocrine secretions. The structural diversity of histo-blood group carbohydrates is highly complex and depends on epistatic interactions among gene-encoding glycosyltransferases...
May 31, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28572839/non-pulmonary-cancer-risk-following-tuberculosis-a-nationwide-retrospective-cohort-study-in-lithuania
#19
Ruta Everatt, Irena Kuzmickiene, Edita Davidaviciene, Saulius Cicenas
BACKGROUND: Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuberculosis and the risk of non-pulmonary cancers has rarely been tested and results have been inconsistent. The aim of this population-based cohort study was to examine the risk of cancer among patients diagnosed with tuberculosis using data from Lithuanian Tuberculosis, Cancer and Resident's Registries...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28571727/efficacy-of-mentha-pulegium-extract-in-the-treatment-of-functional-dyspepsia-a-randomized-double-blind-placebo-controlled-clinical-trial
#20
Ahmad Khonche, Hasan Fallah Huseini, Hamed Abdi, Reza Mohtashami, Farzaneh Nabati, Saeed Kianbakht
ETHNOPHARMACOLOGICAL EVIDENCE: Mentha pulegium L. leaves are used in the Iranian traditional medicine for the treatment of functional dyspepsia. AIM OF STUDY: To study the efficacy and safety of M. pulegium in the treatment of functional dyspepsia patients fulfilling the Rome III criteria. MATERIALS AND METHODS: The efficacy and safety of a standardized Mentha pulegium leaf extract (drug extract ratio: 15.9:1, extraction solvent: 70% v/v aqueous ethanol) (330mg three times daily taken for 2 months) as add-on to one famotidine 40mg tablet per day in the treatment of 50 functional dyspepsia patients were compared with those of a parallel placebo group (n =50)...
May 30, 2017: Journal of Ethnopharmacology
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