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https://www.readbyqxmd.com/read/28934419/characterizing-antigenic-determinants-in-helicobacter-pylori-caga-capable-of-detecting-serum-antibodies-in-children
#1
Min-Kyoung Shin, Jin-Su Jun, Soon-Wook Kwon, Dong-Hae Lee, Jong-Hun Ha, Jin-Sik Park, Hyung Lyun Kang, Seung Chul Baik, Ji Sook Park, Ji-Hyun Seo, Hee-Shang Youn, Myung Je Cho, Woo Kon Lee
Helicobacter pylori can persistently colonize the mucosa of the human stomach, resulting in gastric disorders. Endoscopic biopsy for rapid urease test and histopathologic examination are considered as the most accurate diagnostic methods for H. pylori infection. Serological methods are recommended for children because of invasiveness of the diagnosis mentioned above. Here, the cytotoxin-associated gene A protein (Cag A), as an immunodominant antigen, was subdivided to determine which regions harbor antigenicity for humans...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28932965/best-practice-recommendations-for-diagnosis-and-management-of-helicobacter-pylori-synthesizing-the-guidelines
#2
REVIEW
David J Bjorkman, Matthew Steenblik
Purpose of review Three guidelines on Helicobacter pylori have been published recently with recommendations that differ from past guidelines. In this review, we summarize the Toronto consensus statement, the Maastricht V/Florence consensus report and the American College of Gastroenterology guidelines on H. pylori, comparing and contrasting the recommendations. We also provide a proposed approach integrating the information from all three guidelines. Findings Increasing antibiotic resistance has decreased the effectiveness of past treatment regimens for H...
September 21, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28932367/double-strain-probiotic-effect-on-helicobacter-pylori-infection-treatment-a-double-blinded-randomized-controlled-trial
#3
Mehdi Haghdoost, Sepehr Taghizadeh, Majid Montazer, Parinaz Poorshahverdi, Ali Ramouz, Sanam Fakour
BACKGROUND: A decreased rate of successful helicobacter pylori (H.pylori) infection treatment has revealed serious demand for more effective regimens to eradicate infection. Therefore, probiotics have recently been considered to increase the rate of antibiotic regimens efficacy in H. pylori infections. In current randomized controlled trial, we evaluated the effect of double strain probiotic combination with standard triple therapy (STT), in the eradication rate of H. pylori infection...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28932365/causal-role-of-infectious-agents-in-cancer-an-overview
#4
REVIEW
Jila Masrour-Roudsari, Soheil Ebrahimpour
Cancer is a complex group of diseases with multiple eventual causes. The underlying causes are not fully known. Thus, learning more about the known causes of cancer is an important issue. Moreover, among these factors, infection and its association to cancers is controversial. Although, it seems that the genome instability of the cells can initiate cancer development. The purpose of this review was to present the role of infection in the development of cancer. Infectious agents, such as hepatitis B (HBV) and C viruses (HCV), Epstein-Barr virus (EBV), human papillomavirus (HPV), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori (H...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28932364/role-of-food-in-environmental-transmission-of-helicobacter-pylori
#5
REVIEW
Mohammad Zamani, Amin Vahedi, Zahra Maghdouri, Javad Shokri-Shirvani
Helicobacter pylori (H.pylori) is a gram-negative bacterium that has infected more than half of the world's population. This pathogen colonizes the human gastric mucosa and is usually acquired during childhood. It is an important cause of peptic ulcers, chronic gastritis and stomach cancer. Among the risk factors for acquisition of H. pylori infection, poor socioeconomic status, poor sanitization and hygiene practices, and contaminated food and water, are the most significant ones. The main route of H. pylori transmission is still unknown...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28932213/petri-net-based-model-of-helicobacter-pylori-mediated-disruption-of-tight-junction-proteins-in-stomach-lining-during-gastric-carcinoma
#6
Anam Naz, Ayesha Obaid, Faryal M Awan, Aqsa Ikram, Jamil Ahmad, Amjad Ali
Tight junctions help prevent the passage of digestive enzymes and microorganisms through the space between adjacent epithelial cells lining. However, Helicobacter pylori encoded virulence factors negatively regulate these tight junctions and contribute to dysfunction of gastric mucosa. Here, we have predicted the regulation of important tight junction proteins, such as Zonula occludens-1, Claudin-2 and Connexin32 in the presence of pathogenic proteins. Molecular events such as post translational modifications and crosstalk between phosphorylation, O-glycosylation, palmitoylation and methylation are explored which may compromise the integrity of these tight junction proteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28932087/modified-helicobacter-test-using-a-new-test-meal-and-a-13-c-urea-breath-test-in-helicobacter-pylori-positive-and-negative-dyspepsia-patients-on-proton-pump-inhibitors
#7
Bojan Tepeš, Peter Malfertheiner, Joachim Labenz, Sitke Aygen
AIM: To determine the sensitivity and specificity of the (13)C-urea breath test (UBT) in patients taking proton pump inhibitors (PPIs), using a new test meal Refex. METHODS: One hundred and fourteen consecutive patients with dyspepsia, 53 Helicobacter pylori (H. pylori) positive, 49 H. pylori negative, were included in the study. The patients were then given esomeprazole 40 mg for 29 consecutive days, and the (13)C-UBT with the new test meal was performed the next morning...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28932086/changes-with-aging-in-gastric-biomarkers-levels-and-in-biochemical-factors-associated-with-helicobacter-pylori-infection-in-asymptomatic-chinese-population
#8
Jin-Hua Shan, Xiao-Juan Bai, Lu-Lu Han, Yuan Yuan, Xue-Feng Sun
AIM: To observe changes in gastric biomarker levels with age and effects of Helicobacter pylori (H. pylori) infection in a healthy population, and explore factors associated with gastric biomarkers. METHODS: Three hundred and ninety-five subjects were selected and underwent physical examinations, biochemical tests, and measurement of serum pepsinogen (PG) I and II, gastrin-17 (G-17) and H. pylori antibody levels. Analyses were made by Student's t-test, ANOVA, Pearson's correlation and multiple linear regressions...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28927301/factors-for-improving-the-diagnostic-efficiency-of-the-rapid-urease-test-from-the-gastric-corpus
#9
Jun-Hyung Cho, Seong Ran Jeon, Hyun Gun Kim, So-Young Jin, Suyeon Park
OBJECTIVE: This study aimed to evaluate the optimal biopsy site for Helicobacter pylori detection by comparing the results of rapid urease test (RUT) between the gastric corpus and the antrum. METHODS: A biopsy specimen from each subject was obtained from the corpus and from the antrum. For each subject, the two specimens were separately immersed in two different RUT kits. Positive reaction times were measured at 20 minutes and 1, 3, and 24 hours. If either of the two RUT kits showed a positive reaction, H...
September 19, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28927248/comparison-of-two-methods-for-the-in-vivo-diagnosis-of-helicobacter-pylori-infection-using-a-tablet-of-13c-urea
#10
Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Marina F Alfieri, Ilaria Orlandi, Mariangela Allocca, Silvio Danese
BACKGROUND: The urea Breath-test is a widely-used method to detect the presence of Helicobacter pylori (HP) infection. Recently, new technologies were introduced, to obtain an immediate test result by continuous breath samples analysis after labeled urea intake. The total test duration is shorter than 20 minutes. METHODS: The study compared two diagnostic methods requiring the administration of EXPIROBACTER® (Sofar SpA, Trezzano Rosa, Milan, Italy) 100 mg as a source of labeled urea...
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28927196/the-intricate-interplay-between-msi-and-polymorphisms-of-dna-repair-enzymes-in-gastric-cancer-h-pylori-associated
#11
Isabelle Joyce de Lima Silva-Fernandes, Emanuele Silva de Oliveira, Juliana Carvalho Santos, Marcelo Lima Ribeiro, Adriana Camargo Ferrasi, Maria Inês de Moura Campos Pardini, Rommel Mário Rodriguez Burbano, Silvia Helena Barem Rabenhorst
Gastric cancer is the fourth most common type of cancer worldwide. Helicobacter pylori is a well-established risk factor and may cause injuries to genomic integrity through an inefficient DNA repair. This study aimed to examine the influence of polymorphisms in DNA repair enzymes using markers for microsatellite instability (MSI). Polymorphisms of DNA repair enzymes were detected by PCR-RFLP and MSI, by high resolution melt (HRM) analysis. Helicobacter pylori detection and genotyping were accomplished by PCR...
July 1, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28924022/pan-genomic-analyses-identify-key-helicobacter-pylori-pathogenic-loci-modified-by-carcinogenic-host-microenvironments
#12
Jennifer M Noto, Abha Chopra, John T Loh, Judith Romero-Gallo, M Blanca Piazuelo, Mark Watson, Shay Leary, Amber C Beckett, Keith T Wilson, Timothy L Cover, Simon Mallal, Dawn A Israel, Richard M Peek
OBJECTIVE: Helicobacter pylori is the strongest risk factor for gastric cancer; however, the majority of infected individuals do not develop disease. Pathological outcomes are mediated by complex interactions among bacterial, host and environmental constituents, and two dietary factors linked with gastric cancer risk are iron deficiency and high salt. We hypothesised that prolonged adaptation of H. pylori to in vivo carcinogenic microenvironments results in genetic modification important for disease...
September 18, 2017: Gut
https://www.readbyqxmd.com/read/28922433/bismuth-based-quadruple-therapy-following-h-pylori-eradication-failures-a-multicenter-study-in-clinical-practice
#13
Angelo Zullo, Vincenzo De Francesco, Annamaria Bellesia, Roberto Vassallo, Audenzio D'Angelo, Giuseppe Scaccianoce, Rodolfo Sacco, Giampaolo Bresci, Annarita Eramo, Anna Tanzilli, Lorenzo Ridola, Domenico Alvaro, Claudio Londoni, Gianfranco Brambilla, Raffaele Manta, Agostino Di Ciaula, Piero Portincasa
BACKGROUND AND AIMS: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice. METHODS: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28920420/metachronous-gastric-cancer-following-curative-endoscopic-resection-of-early-gastric-cancer
#14
Seiichiro Abe, Ichiro Oda, Takeyoshi Minagawa, Masau Sekiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Amit Bhatt, Yutaka Saito
This review article summarizes knowledge about metachronous gastric cancer (MGC) occurring after curative endoscopic resection (ER) of early gastric cancer (EGC), treatment outcomes of patients who developed MGC, and efficacy of Helicobacter pylori eradication to prevent MGC. The incidence of MGC following curative ER increases over time and is higher than in patients undergoing gastrectomy. Increasing age and multifocal EGC are independent risk factors for developing MGC. An MGC following curative ER is usually a small (<20 mm) and differentiated intramucosal cancer...
September 18, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28919599/clinico-biochemical-profile-of-women-with-hyperemesis-gravidarum-admitted-in-a-tertiary-hospital
#15
S Kabir, M S Basher, H Akhter, T Latif, S N Akhter, R K Karmoker, S A Shaon, K Ahmed
Hyperemesis gravidarum is the most severe form of nausea and vomiting in pregnancy with poor pregnancy outcome. Hormonal changes, psychological and immunological factors are attributed to the condition. Recently, prevalence of Helicobacter pylori among women with Hyperemesis gravidarum has been revealed. A descriptive, cross-sectional study was carried out at antenatal ward, Department of Obstetrics and Gynaecology, Mymensingh Medical College Hospital, Mymensingh among thirty-six purposively selected patients with Hyperemesis gravidarum to assess the clinic-biochemical profile...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28918609/associations-among-gastric-juice-ph-atrophic-gastritis-intestinal-metaplasia-and-helicobacter-pylori-infection
#16
Jihee Sung, Nayoung Kim, Jongchan Lee, Young-Jae Hwang, Hyoung Woo Kim, Jung Wha Chung, Jin-Wook Kim, Dong Ho Lee
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio and interleukin (IL)-1β levels were measured...
September 19, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28914844/-molecular-genetic-predictors-of-resistance-to-anti-helicobacter-pylori-therapy
#17
I V Maev, D N Andreev
In current clinical practice, there is no optimal empirical therapy for Helicobacter pylori (H. pylori) infection and there is a progressive decrease in the efficiency of classical eradication therapy (ET) regimens. The variability in the efficiency of ET in a specific patient is largely due to the heterogeneous molecular genetic mechanisms underlying the resistance of the microorganism to the components of the treatment regimens. The basis of the mechanisms for antibiotic resistance in H. pylori is mainly the point mutations in some genes, which determine alterations in the mechanisms of action of drugs, such as clarithromycin (domain V of 23S rRNA), metronidazole (rdxA, frxA), amoxicillin (pbp1A), tetracycline (16S rRNA), and levofloxacin (gyrA)...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28913872/high-primary-antibiotic-resistance-of-helicobacter-pylori-strains-isolated-from-dyspeptic-patients-a-prevalence-cross-sectional-study-in-spain
#18
Fernando Macías-García, José Llovo-Taboada, Mario Díaz-López, Iria Bastón-Rey, Juan Enrique Domínguez-Muñoz
BACKGROUND: The rate of H. pylori resistance to different antibiotics is increasing and determines the selection of eradication therapy. The aim of this study was to determine the resistance patterns of H. pylori strains in our area. METHODS: Biopsies from gastric corpus for microbiological culture and antibiotic resistance were obtained in patients undergoing upper gastrointestinal endoscopy for dyspepsia. Selective Agar Pylori for isolation of the bacteria and Agar Mueller-Hinton supplemented with blood to test the sensitivity to antibiotics were used...
September 15, 2017: Helicobacter
https://www.readbyqxmd.com/read/28912838/phylogenomics-of-colombian-helicobacter-pylori-isolates
#19
Andrés Julián Gutiérrez-Escobar, Esperanza Trujillo, Orlando Acevedo, María Mercedes Bravo
BACKGROUND: During the Spanish colonisation of South America, African slaves and Europeans arrived in the continent with their corresponding load of pathogens, including Helicobacter pylori. Colombian strains have been clustered with the hpEurope population and with the hspWestAfrica subpopulation in multilocus sequence typing (MLST) studies. However, ancestry studies have revealed the presence of population components specific to H. pylori in Colombia. The aim of this study was to perform a thorough phylogenomic analysis to describe the evolution of the Colombian urban H...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28902909/the-cytoprotective-protein-clusterin-is-overexpressed-in-hypergastrinemic-rodent-models-of-oxyntic-preneoplasia-and-promotes-gastric-cancer-cell-survival
#20
Pål Vange, Torunn Bruland, Berit Doseth, Reidar Fossmark, Mirta M L Sousa, Vidar Beisvag, Øystein Sørdal, Gunnar Qvigstad, Helge L Waldum, Arne K Sandvik, Ingunn Bakke
The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated spasmolytic polypeptide-expressing metaplasia (SPEM). The hormone gastrin is important for normal function and maturation of the gastric oxyntic mucosa and hypergastrinemia might be involved in gastric carcinogenesis. Gastrin induces expression of clusterin in adenocarcinoma cells. In the present study, we examined the expression patterns and gastrin-mediated regulation of clusterin in gastric tissue from: humans; rats treated with proton pump (H+/K+-ATPase) inhibitors and/or a gastrin receptor (CCK2R) antagonist; H+/K+-ATPase β-subunit knockout (H/K-β KO) mice; and Mongolian gerbils infected with Helicobacter pylori and given a CCK2R antagonist...
2017: PloS One
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