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https://www.readbyqxmd.com/read/28324746/denosumab-in-advanced-unresectable-giant-cell-tumour-of-bone-gctb-for-how-long
#1
E Palmerini, N S Chawla, S Ferrari, M Sudan, P Picci, E Marchesi, M Piccinni Leopardi, I Syed, K K Sankhala, P Parthasarathy, W E Mendanha, M Pierini, A Paioli, S P Chawla
BACKGROUND: Giant-cell tumours of bone (GCTB) are RANK/RANK-ligand (RANKL) positive, aggressive and progressive osteolytic tumours. Denosumab, a RANKL inhibitor, was FDA-approved for adults and skeletally mature adolescents with unresectable GCTB or when surgical resection is likely to result in severe morbidity. Data on long-term toxicity and activity of denosumab monthly 'GCTB-schedule' (120 mg per 12/year, 1440 mg total dose/year) are lacking. METHODS: Patients with GCTB receiving denosumab, 120 mg on days 1, 8, 15, 29 and every 4 weeks thereafter, from 2006 to 2015 treated in two centres were included...
March 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28317829/-modern-approaches-to-dental-implants-placement-in-deficient-alveolar-bone
#2
A A Kulakov, R Sh Gvetadze, T V Brailovskaya, A A Khar'kova, L S Dzikovitskaya
The paper presents statistical data on implant placement procedures in Central Research Institute of Dentistry and Maxillofacial Surgery (Moscow, Russia) in 2010-2015. In 64% of cases inadequate bone volume was attributed to alveolar bone atrophy. Bone deficiency was equally often in upper and lower jaws (in 49.3 and 50.7%, correspondently) but varied in forms with complex configurations to be more specific for maxilla. The study also includes a series of clinical cases illustrating implant placement procedures in anatomically unfavorable settings...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28317352/-clinical-analysis-of-bisphosphonate-related-osteonecrosis-of-the-jaw
#3
Gong Jiaxing, Wang Huiming
OBJECTIVE: The study aims to analyze patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ). METHODS: Twelve patients treated in the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Me-dical School, Zhejiang University from May 2013 to September 2015 were included. Patients' basic situation, medication, clinical symptoms, therapies, and effects were obtained and analyzed. RESULTS: The treatment of nine patients focused on the mandible, whereas that of three patients was on the maxilla...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28316283/combination-therapies-for-the-treatment-of-recurrent-central-giant-cell-lesion-in-the-maxilla-a-case-report
#4
Jefferson Paulo de Oliveira, Fernanda Olivete, Naylin Danyele de Oliveira, Allan Fernando Giovanini, João César Zielak, Leandro Klüppel, Rafaela Scariot
BACKGROUND: Central giant cell lesion is a non-neoplastic proliferation, usually asymptomatic, of unknown etiology. The purpose of this case report is to report the diagnosis and the treatment of a recurrent central giant cell lesion in the maxilla. CASE PRESENTATION: A 31-year-old Brazilian woman presented to our Surgery Service for evaluation of a cystic lesion in her teeth 13 and 15, although she had previously received endodontic treatment for her teeth 13 and 15 without regression of the lesion...
March 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28299273/guidelines-for-patient-specific-jawline-definition-with-titanium-implants-in-esthetic-deformity-and-malformation-surgery
#5
Maurice Yves Mommaerts
CONTEXT: Asymmetry and unfavorable esthetics of the jawline have become possible to correct in three dimensions using computer aided design and computer aided manufacturing. AIMS: The aim of this study was to provide esthetic, technical, and operative guidelines for mandibular angle and border augmentation using patient-specific titanium implants made by selective laser melting. SETTINGS AND DESIGN: University hospital - prospective registry...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28299027/the-effect-of-locally-administered-pamidronate-on-autogenous-bone-graft-in-maxillofacial-reconstruction-a-randomized-clinical-trial
#6
M Bayat, A Garajei, E Afshari Pour, M Hasheminasab, Y Ghorbani, M H Kalantar Motamedi, N Bahrami
BACKGROUND: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption. OBJECTIVE: To assess the effect of administration of biphosphonates on bone resorption. METHODS: 20 patients with bony defects who were candidates for free autogenous grafts were randomized into "pamidronate" and "control" groups...
2017: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/28296728/a-meta-analysis-comparing-the-outcomes-of-ligasure-small-jaw-versus-clamp-and-tie-technique-or-harmonic-focus-scalpel-in-thyroidectomy
#7
Lei Zhang, Namei Li, Xuemei Yang, Jie Chen
BACKGROUND: LigaSure (LS) Small Jaw is a surgical hemostasis equipment that is newly introduced in thyroid surgery. The objective of this study is to assess the short-term efficacy and safety outcomes of LS Small Jaw compared with clamp-and-tie technique or Harmonic Focus Scalpel in thyroidectomy. METHODS: A literature search was performed in the PubMed and Embase databases (until June 12, 2016) that reported the comparisons between LS Small Jaw and other techniques in thyroidectomy...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28293491/disparities-in-utilization-of-jaw-surgery-for-treatment-of-sleep-apnea-a-nationwide-analysis
#8
Ravi K Garg, Ying Shan, Jeffrey A Havlena, Ahmed M Afifi
BACKGROUND: Maxillomandibular advancement has been shown to be one of the most effective operations for management of severe obstructive sleep apnea, yet pharyngeal surgery is more commonly performed. The goal of this study was to identify socioeconomic factors associated with this phenomenon. METHODS: Patients aged 14 or older with a primary hospital diagnosis of sleep apnea were identified using the National Inpatient Sample from 2005 to 2012. ICD9 codes were used to determine whether a pharyngeal or jaw procedure was performed...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28291396/mandibular-reconstruction-by-using-a-liquid-nitrogen-treated-autograft-in-a-dog-with-an-oral-tumor
#9
Yasuhiko Okamura, Kazuki Heishima, Tomoki Motegi, Jun Sasaki, Masanobu Goryo, Hideji Nishida, Hiroyuki Tsuchiya, Masaaki Katayama, Yuji Uzuka
A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. It was subsequently reimplanted. New bone tissue formed in the gap between the frozen bone and the host bone. The regenerated bone contained osteocytes, osteoblasts, and blood vessels. The cosmetic appearance of the dog was preserved...
March 14, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28286399/application-of-4-meta-adhesive-resin-to-the-occlusal-surface-during-surgery-facilitates-postoperative-occlusal-management
#10
Aoki Noriaki, Baba Junichi, Iwai Toshinori, Tohnai Iwai
PURPOSE: Orthognathic surgery is generally used to correct facial deformities and establish functional occlusion. Preoperative orthodontic treatment is important for stabilizing and establishing the postoperative occlusion. However, sufficient preoperative surgical orthodontic treatment might be sometimes difficult in patients with an abnormally shaped maxilla or mandible or severe jaw deformity. METHODS: We performed this technique over 10 patients with jaw deformities after insufficient presurgical orthodontic treatment...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28282517/risk-factor-analysis-of-graft-failure-with-concomitant-cyst-enucleation-of-the-jaw-bone-a-retrospective-multicenter-study
#11
Ho-Kyung Lim, Jin-Woo Kim, Ui-Lyong Lee, Ju-Won Kim, Ho Lee
PURPOSE: Cysts are common pathologic entities in the oral and maxillofacial region. Enucleation is commonly used for treatment and is occasionally followed by bone grafting. However, no studies have evaluated factors affecting the failure of grafts used for cystic defects in the oral and maxillofacial region. Therefore, the present study was conducted to determine the risk factors for postoperative graft failure in patients treated with cyst enucleation and simultaneous bone grafting...
February 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28280710/the-postoperative-trismus-nerve-injury-and-secondary-angle-formation-after-partial-masseter-muscle-resection-combined-with-mandibular-angle-reduction-a-case-report
#12
Jeong-Hwan Kim, Seong-Un Lim, Ki-Su Jin, Ho Lee, Yoon-Sic Han
A patient, who underwent partial masseter muscle resection and mandibular angle reduction at a plastic surgery clinic, visited this hospital with major complaints of trismus and dysesthesia. A secondary angle formation due to a wrong surgical method was observed via clinical and radiological examinations, and the patient complained of trismus due to the postoperative scars and muscular atrophy caused by the masseter muscle resection. The need for a masseter muscle resection in square jaw patients must be approached with caution...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28274035/stability-of-vertical-horizontal-and-angular-parameters-following-superior-repositioning-of-maxilla-by-le-fort-i-osteotomy-a-cephalometric-study
#13
Pruthvi Raj Hanthur Venkategowda, A T Prakash, E T Roy, K Sadashiva Shetty, Surbhi Thakkar, Rajkumar Maurya
INTRODUCTION: The restoration of normal jaw function, optimal facial aesthetics and long term stability are the goals of any orthognathic surgical procedures. During the last two decades, several cephalometric investigations have been reported on the skeletal changes following maxillary surgical procedures. The stability following LeFort I osteotomy and maxillary superior repositioning of the maxilla has not been studied extensively. AIM: This study was aimed at determining the surgical changes brought about by superior repositioning of the maxilla by Le Fort I osteotomy and evaluate the stability of the surgical procedure one year following surgery...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273221/keratocystic-odontogenic-tumor
#14
Brenda DE Souza Moura, Maria Aparecida Cavalcante, Wagner Hespanhol
to evaluate the frequency of keratocystic odontogenic tumor (KOT) in the Oral Surgery Service (OSS) of the University Hospital Clementino Fraga Filho of the Federal University of Rio de Janeiro (HUCFF / UFRJ), with respect to recurrence rate, gender, age of recurrence and location of the injury Methods: clinical records were reviewed and histopathological reports of KOT patients of the HUCFF/UFRJ between 2002 and 2012. Patients diagnosed with KOT were divided into two groups for the occurrence of relapse: positive (n=6) and negative (n=19) Results: regarding the location, there was a predilection for the mandible...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28272008/an-expansile-well-defined-radiolucency-in-anterior-mandible-case-presentation-with-treatment-approach-and-literature-update
#15
Shelly Arora, Aadithya B Urs, Zainab Choudhary
A 15-year-old Indian male patient presented with a history of pain and swelling in left mandible. Imaging studies revealed a well-defined unilocular radiolucency in the body of the mandible. Patient also gave the past history of the surgery of the jaws, which was histopathologically diagnosed as dentigerous cyst. Following this patient underwent incisional biopsy and later excisional biopsy. The histopathologic diagnosis for incisional biopsy was unicystic ameloblastoma but final diagnosis was dentinogenic ghost cell tumor for the excised tissue...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28270172/neoadjuvant-folfox-chemotherapy-combined-with-radiotherapy-followed-by-radical-resection-in-patients-with-locally-advanced-colon-cancer
#16
Chun-Ming Huang, Ming-Yii Huang, Cheng-Jen Ma, Yung -Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Chih-Jen Huang, Jaw-Yuan Wang
BACKGROUND: Patients with locally advanced colon cancer (LACC) have a relatively poor prognosis despite radical resection and adjuvant chemotherapy. This study investigated the treatment efficacy and toxicity of neoadjuvant chemoradiotherapy in patients with LACC. METHODS: We retrospectively reviewed 36 patients with LACC preoperatively treated with chemotherapy and radiotherapy. Patients were administered chemoradiotherapy, which comprised radiotherapy and neoadjuvant chemotherapy involving a 5-fluorouracil, leucovorin, and oxaliplatin regimen every 2 weeks...
March 7, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28267831/associations-between-early-implant-failure-patient-age-and-patient-mortality-a-15-year-follow-up-study-on-2-566-patients-treated-with-implant-supported-prostheses-in-the-edentulous-jaw
#17
Torsten Jemt, Mats Nilsson, Malin Olsson, Victoria Franke Stenport
PURPOSE: The aim of this study was to report the distribution of patients with early implant failures after implant treatment in the edentulous jaw with regard to age at surgery and association with patient mortality over a 15-year period. MATERIALS AND METHODS: All consecutively treated patients treated in the edentulous jaw at a single specialist clinic from 1986 to 1997 were included and followed up for 1 year for implant failures and for 15 years with regard to patient mortality...
March 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28258918/evaluation-of-bone-resorption-in-fibula-and-deep-circumflex-iliac-artery-flaps-following-dental-implantation-a-three-year-follow-up-study
#18
Kristian Kniha, Stephan Christian Möhlhenrich, Ann Christina Foldenauer, Florian Peters, Nassim Ayoub, Evgeny Goloborodko, Frank Hölzle, Ali Modabber
Long-term results of dental implant treatment in fibula free and deep circumflex iliac artery (DCIA) free flaps are scarce. The purpose of this study was to assess and compare peri-implant bone resorption of vascularized bone flaps treated with dental implants. A total of 28 patients, 14 fibula and 14 DCIA flaps, respectively, underwent reconstruction of the lower and upper jaw by the use of vascularized bone flaps and were treated with dental implants. Peri-implant bone resorption was measured using digital panographs up to 3 years...
January 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28258274/early-orthognathic-surgery-a-review
#19
Saleh Alwadei
Management of growing patients with severe developmental jaw abnormalities can be very difficult. Early surgical intervention may be warranted in situations where function (e.g., mastication, swallowing, breathing, or speech) and/or psychological well-being could be negatively affected. Many surgeons and orthodontists are reluctant to recommend a surgical treatment option for growing patients with severe developmental jaw abnormalities because of their age. Specific surgical procedures can be performed during growth to correct developmental jaw abnormalities with predictable results...
March 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28257487/cone-beam-computed-tomography-evaluation-of-the-maxillofacial-features-of-patients-with-unilateral-temporomandibular-joint-ankylosis-undergoing-condylar-reconstruction-with-an-autogenous-coronoid-process-graft
#20
Li Liu, Jiayang Li, Huanzhong Ji, Nian Zhang, Yiyao Wang, Guangning Zheng, Hu Wang, En Luo
OBJECTIVE: To evaluate the changes in the jaws and the upper airways of unilateral temporomandibular joint ankylosis patients who underwent condylar reconstruction via autogenous coronoid process grafts using cone-beam computed tomography (CBCT). STUDY DESIGN: The 27 included patients underwent CBCT examinations at three stages: T0 (within two weeks before surgery), T1 (two weeks after surgery), and T2 (an average of 13 months after surgery). Forty items related to the maxillofacial hard tissues and the upper airway collected at the three times and the coronoid process graft volumes after surgery were compared...
2017: PloS One
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