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https://www.readbyqxmd.com/read/29905044/-correlation-analysis-between-interleukin-6-polymorphism-and-adolescent-idiopathic-scoliosis-susceptibility-and-bracing-effectiveness
#1
Junsheng Gao, Lu Zhang, Zhiang Liu, Shuaihui Yao, Songming Gao
Objective: To analyze the correlation between the polymorphism on interleukin 6 (IL-6) gene promoter region-174 locus and adolescent idiopathic scoliosis (AIS), including the susceptibility, the bracing effectiveness, and the possible mechanism. Methods: The 182 AIS patients and 210 healthy controls who met the inclusion criteria between January 2013 and January 2016 were collected as research objects. The genotype of IL-6 gene promoter region-174 locus, the serum IL-6, the bone mineral density (BMD) of femoral neck and vertebrae (L 1-4 ), and the bone metabolism parameters, including bone alkaline phosphatase (BALP), bone gla protein (BGP), tartrate resistant acid phosphatase 5b (TRACP-5b), urine Ca, and urine Ca/Cr, were detected...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29886487/transition-of-care-from-childhood-to-adulthood-congenital-adrenal-hyperplasia
#2
Anne Bachelot
Deficiency of the 21-hydroxylase enzyme is the most common form of congenital adrenal hyperplasia (CAH), accounting for more than 95% of the cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, impaired bone mineral density, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and practitioners...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29886481/growth-hormone-deficiency-in-the-transition-age
#3
Sandro Loche, Natascia Di Iorgi, Giuseppa Patti, Serena Noli, Marta Giaccardi, Irene Olivieri, Anastasia Ibba, Mohamad Maghnie
Growth hormone (GH) is essential not only for normal growth during childhood, but also for the acquisition of bone mass and muscle strength in both sexes. This process is completed after the achievement of adult height in the phase of transition from adolescence to adulthood. Adolescents with childhood onset GH deficiency (GHD) show reduction of bone mineral density, decrease in lean body mass, increase in fat mass, and deterioration of the lipid profile. For this reason, continuation of GH replacement therapy in the transition age is recommended in all patients with a confirmed diagnosis of GHD...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29885146/heavy-episodic-drinking-is-associated-with-poorer-bone-health-in-adolescent-and-young-adult-women
#4
Joseph W LaBrie, Sarah Boyle, Andrew Earle, Hawley C Almstedt
OBJECTIVE: Osteoporosis is a costly bone disease characterized by low bone mineral density (BMD) that primarily affects postmenopausal women. One factor that may lead to osteoporosis is a failure to reach peak bone mass (PBM) in early adulthood. In older adults and animal models, heavy episodic drinking (HED) has been found to predict failure to reach PBM. However, this relationship has yet to be investigated in adolescent human females. METHOD: Female college students (N = 87; 60% White) reported age at menarche, hormonal contraceptive use, physical activity, smoking habits, and HED history via an online survey and then received a dual energy x-ray absorptiometry bone scan to assess both lean body mass and BMD at the lumbar spine...
May 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29877636/the-assessment-of-skeletal-status-in-young-patients-with-turner-syndrome-by-2-densitometric-techniques-phalangeal-quantitative-ultrasound-and-dual-energy-x-ray-absorptiometry
#5
Beata Wikiera, Agata Mierzwicka, Aleksander Basiak, Jowita Halupczok-Żyła, Diana Jędrzejuk, Magdalena Cabała, Anna Noczyńska, Marek Bolanowski, Kornel Mikołajczyk, Zenon P Halaba
BACKGROUND: Studies using dual energy X-ray absorptiometry (DXA) demonstrate a reduction in bone mineral density (BMD) in children and adolescents with Turner syndrome (TS). However, these studies do not take into account changes in bone size, which influence BMD in the case of short-statured patients. Phalangeal quantitative ultrasound (phQUS) measurements have shown an ability to reveal changes due to skeletal growth, aging, and bone and mineral disorders. There is limited data on bone mineral status in girls with TS assessed by 2 different techniques, i...
June 4, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29789712/distribution-and-determinants-of-retinol-in-norwegian-adolescents-and-its-relation-to-bone-mineral-density-the-troms%C3%A3-study-fit-futures
#6
M S W Teigmo, T E Gundersen, N Emaus, G Grimnes
BACKGROUND/OBJECTIVES: Sufficient vitamin A levels are important for many functions-and both too little and too much may have detrimental health effects. The aim of the study was to describe the distribution of retinol levels in Norwegian adolescents, the relation between lifestyle factors and retinol levels, and the relation between retinol levels and bone mineral density (BMD). SUBJECTS/METHODS: Serum retinol was measured in 414 girls and 474 boys aged 15-19 years, participating in the Tromsø Study: Fit Futures...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29789442/ovine-prenatal-growth-restriction-impacts-glucose-metabolism-and-body-composition-throughout-life-in-both-sexes
#7
Jacqueline M Wallace, John S Milne, Raymond P Aitken, Graham W Horgan, Clare L Adam
Low birthweight is a risk factor for later adverse health. Here the impact of placentally-mediated prenatal growth-restriction followed by postnatal nutrient abundance on growth, glucose metabolism and body composition was assessed in both sexes at key stages from birth to mid-adult life. Singleton-bearing adolescent dams were fed control or high nutrient intakes to induce normal or growth-restricted pregnancies, respectively. Restricted lambs had ~40% reduced birthweight. Fractional growth rates were higher in restricted lambs of both sexes predominantly during suckling/juvenile phases...
May 22, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29783019/total-flavonoid-extract-of-epimedium-herb-increases-the-peak-bone-mass-of-young-rats-involving-enhanced-activation-of-the-ac10-camp-pka-creb-pathway
#8
Hui-Rong Xi, Hui-Ping Ma, Fang-Fang Yang, Yu-Hai Gao, Jian Zhou, Yuan-Yuan Wang, Wen-Yuan Li, Cory J Xian, Ke-Ming Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium sagittatum brevicornum Maxim. is an important traditional Chinese herb that has long been used to promote bone fracture healing and treat osteoporosis. AIM OF THE STUDY: Achieving peak bone mass by adolescence has now been accepted to be fundamental for preventing osteoporosis in adulthood life. This study investigated the possibility of increasing peak bone mass in young rats using the total flavonoid extract of Epimedium herb (TFE)...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29769826/effects-of-gymnastics-activities-on-bone-accrual-during-growth-a-systematic-review
#9
REVIEW
Jaak Jürimäe, Rita Gruodyte-Raciene, Adam D G Baxter-Jones
The amount of bone gained during childhood and adolescence impacts greatly on lifetime skeletal health. The purpose of this review is to summarize current evidence of the effects of gymnastics activities on bone mineral accrual during growth and to describe possible factors that influence bone mineral gains. The PubMed and SportDiscus databases were searched, and a total of 24 articles met the selection criteria and were included in this review. Artistic and rhythmic gymnasts presented higher bone mineral density and content values compared to untrained controls, despite possible negative effects associated with hormonal levels, dietary restrictions and body fat...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#10
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29739679/low-trabecular-bone-score-in-adolescent-female-inpatients-with-anorexia-nervosa
#11
Yael Levy-Shraga, Liana Tripto-Shkolnik, Dana David, Iris Vered, Daniel Stein, Dalit Modan-Moses
BACKGROUND & AIMS: Trabecular bone score (TBS) is an emerging technology that provides information regarding bone microarchitecture. A recent study showed that in healthy girls normal TBS (≥1.35) was achieved within the first year post-menarche. The aims of our study was to assess TBS in adolescents with anorexia nervosa (AN) and to evaluate correlations with clinical, laboratory and densitometric variables. METHODS: A cohort study of 208 adolescent females (mean age 15...
April 26, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29679731/changes-in-pediatric-dxa-measures-of-musculoskeletal-outcomes-and-correlation-with-quantitative-ct-following-treatment-of-acute-lymphoblastic-leukemia
#12
Sogol Mostoufi-Moab, Andrea Kelly, Jonathan A Mitchell, Joshua Baker, Babette S Zemel, Jill Brodsky, Jin Long, Mary B Leonard
We previously reported significant gains in pQCT measures of tibia trabecular bone mineral density (BMD) and cortical structure following completion of therapy in children and adolescents with acute lymphoblastic leukemia (ALL). The objective of this study was to examine changes in DXA measures used in clinical practice and expressed as Z-scores using robust national reference data. Children and adolescents, ages 5 to 18 years were enrolled within 2 (median 0.8) years of completing ALL therapy. DXA total-body less-head bone mineral content (TBLH-BMC), and spine, total hip, femoral neck, and 1/3rd radius areal BMD (aBMD) were assessed in 45 participants at enrollment and 12-months later...
July 2018: Bone
https://www.readbyqxmd.com/read/29672273/bone-mineral-density-comparison-of-adolescents-with-constitutional-thinness-and-anorexia-nervosa
#13
Melis Pehlivantürk Kızılkan, Sinem Akgül, Orhan Derman, Nuray Kanbur
BACKGROUND: The negative impact of anorexia nervosa (AN) on bone health is well defined. However, there are very few studies evaluating the effect of constitutional thinness on bone health, especially in the adolescent period and in the male gender. The aim of this study is to compare the bone mineral density (BMD) measurements of adolescents with AN and with constitutional thinness. METHODS: Between April 2013 and March 2014, 40 adolescents with AN and 36 adolescents with constitutional thinness participated in the study...
April 25, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29662776/three-dimensional-morphometric-properties-of-rod-and-plate-like-trabeculae-in-adolescent-cancellous-bone
#14
Ming Ding, Xiaozhe Lin, Wenge Liu
Background/Objective: Despite many researches have been carried out on the three-dimensional microarchitecture of cancellous bone, the morphometric properties of rod and plate trabeculae in adolescent cancellous bone have not yet been investigated. This study aimed to investigate three-dimensional morphometric properties of rod- and plate-like trabeculae in normal adolescent cancellous bone, and to compare them with adult cancellous bones to reveal morphometric changes from adolescence to adult life to obtain more insight into the subchondral bone adaptations during development and growth...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662267/decrement-in-bone-mineral-density-after-parathyroidectomy-in-a-pediatric-patient-with-primary-hyperparathyroidism
#15
Hidechika Morimoto, Hisakazu Nakajima, Jun Mori, Shota Fukuhara, Keiichi Shigehara, Shinsuke Adachi, Hajime Hosoi
Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Here, we report a case of a 13-yr-old boy with PHT who was referred to our institution for evaluation of hypercalcemia and hyperparathyroidism. Radiological investigation revealed an ectopic parathyroid adenoma below the right thyroid lobe...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29657025/physical-fitness-adiposity-and-diets-as-surrogate-measures-of-bone-health-in-schoolchildren-a-biochemical-and-cross-sectional-survey-analysis
#16
Ahmad H Alghadir, Sami A Gabr, Ashraf A Rizk
This study aimed to investigate the associations between adiposity, muscular fitness (MF), diet, sun exposure, and physical activity profiles as surrogate measures with bone health status in a sample of schoolchildren aged 8-18 yr old. A total of 250 Egyptian schoolchildren aged 8-18 yr were randomly invited to participate in these cross-sectional survey analyses. Calcaneal broadband ultrasound attenuation (c-BUA), bone mineral density (BMD), and bone formation markers (total calcium, serum bone alkaline phosphatase, and osteocalcin) were measured as markers of bone health...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29619932/mortality-and-morbidity-in-patients-with-osteogenesis-imperfecta-in-denmark
#17
Lars Folkestad
Ostegenesis imperfecta (OI) is a hereditary disease of the connective tissue caused by mutations to, mainly, the genes that are involved in the biosynthesis of collagen type 1. Patients are grouped according to clinical severity and mode of inheritance according to Sillence's classification (originally 1979, updated 2014). According to our data, the population prevalence of OI in Denmark was 10.3 per 100,000, with 575 patients registered with an OI diagnosis in the National Patient Register and alive at the end of 2012 out of a total population of 5,602,628 persons...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29601899/longitudinal-changes-in-bone-parameters-in-young-girls-with-anorexia-nervosa
#18
Sheila Shepherd, Andreas Kyriakou, Mohamed Guftar Shaikh, Helen McDevitt, Charlotte Oakley, Michelle Thrower, S Faisal Ahmed, Avril Mason
BACKGROUND: Anorexia nervosa (AN) during childhood and adolescence has been reported to adversely affect bone health, but few studies have investigated longitudinal changes. METHOD: DXA-derived bone parameters and body composition were retrospectively assessed in 111 young girls with AN with a median age of 15.4 years (10.9, 19.8). In 68 (61%) vertebral fracture assessment (VFA) was performed and in 31 (28%), a follow-up DXA was performed. Correlations with growth, changes in body composition and effects of illness duration and menstruation were examined...
March 27, 2018: Bone
https://www.readbyqxmd.com/read/29594644/non-osteogenic-muscle-hypertrophy-in-children-with-mcardle-disease
#19
I Rodríguez-Gómez, A Santalla, J Díez-Bermejo, D Munguía-Izquierdo, L M Alegre, G Nogales-Gadea, J Arenas, M A Martín, A Lucía, I Ara
INTRODUCTION: McArdle disease is an inborn disorder of muscle glycogen metabolism that produces exercise intolerance, and has been recently associated with low values ​​of lean mass (LM) and bone mineral content (BMC) and density (BMD) in affected adults. Here we aimed to study whether this bone health problem begins in childhood. METHODS: Forty children and adolescents were evaluated: 10 McArdle disease and 30 control children (mean age of both groups, 13 ± 2y)...
March 28, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29569996/adults-engaged-in-sports-in-early-life-have-higher-bone-mass-than-their-inactive-peers
#20
Alessandra Madia Mantovani, Manoel Carlos Spiguel de Lima, Luis Alberto Gobbo, Enio Ricardo Vaz Ronque, Marcelo Romanzini, Bruna Camilo Turi-Lynch, Jamile Sanches Codogno, Rômulo Araújo Fernandes
PURPOSE: To analyze the relationship between engagement in sports in early life and bone variables among adults of both sexes. METHODS: The sample was composed of 225 men and women. Demographic data were collected, and dual-energy X-ray absorptiometry was used to assess bone mineral density, bone mineral content, and lean soft tissue. Sports participation in early life was assessed by an interview including childhood and adolescence. Consumption of tobacco and alcohol was also assessed by interview and the habitual physical activity level by a pedometer...
March 23, 2018: Journal of Physical Activity & Health
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