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https://www.readbyqxmd.com/read/28542240/wmel-limits-zika-and-chikungunya-virus-infection-in-a-singapore-wolbachia-introgressed-ae-aegypti-strain-wmel-sg
#1
Cheong Huat Tan, PeiSze Jeslyn Wong, Meizhi Irene Li, HuiTing Yang, Lee Ching Ng, Scott Leslie O'Neill
BACKGROUND: Zika (ZIKV) and Chikungunya (CHIKV) viruses are emerging Aedes-borne viruses that are spreading outside their known geographic range and causing wide-scale epidemics. It has been reported that these viruses can be transmitted efficiently by Ae. aegypti. Recent studies have shown that Ae. aegypti when transinfected with certain Wolbachia strains shows a reduced replication and dissemination of dengue (DENV), Chikungunya (CHIKV), and Yellow Fever (YFV) viruses. The aim of this study was to determine whether the wMel strain of Wolbachia introgressed onto a Singapore Ae...
May 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28539441/chikungunya-virus-overcomes-polyamine-depletion-by-mutation-of-nsp1-and-the-opal-stop-codon-to-confer-enhanced-replication-and-fitness
#2
Bryan C Mounce, Teresa Cesaro, Lea Vlajnić, Anna Vidiņa, Thomas Vallet, James Weger-Lucarelli, Gabriella Pasoni, Kenneth A Stapleford, Jean-Pierre Levraud, Marco Vignuzzi
Polyamines, small positively-charge molecules present in all cells, play important roles in the replication of DNA and RNA viruses. Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological depletion of polyamines limits viral replication. However, the potential development of antiviral resistance necessitates a better understanding of how polyamines function and can be targeted via compounds that alter polyamine levels. We have isolated CHIKV that is resistant to polyamine depletion that contains two mutations in the non-structural protein 1 (nsP1) coding region in combination with mutation to the opal stop codon preceding nsP4...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28536430/aetiology-of-acute-meningoencephalitis-in-cambodian-children-2010-2013
#3
Paul F Horwood, Veasna Duong, Denis Laurent, Channa Mey, Heng Sothy, Ky Santy, Beat Richner, Seiha Heng, Sopheak Hem, Justine Cheval, Christopher Gorman, Philippe Dussart, Menno D de Jong, Alexandra Kerleguer, Bertrand Guillard, Bernadette Murgue, Marc Lecuit, Xavier de Lamballerie, Jeremy J Farrar, Arnaud Tarantola, Marc Eloit, Philippe Buchy
Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV)...
May 24, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28506207/the-midgut-transcriptome-of-aedes-aegypti-fed-with-saline-or-protein-meals-containing-chikungunya-virus-reveals-genes-potentially-involved-in-viral-midgut-escape
#4
Shengzhang Dong, Susanta K Behura, Alexander W E Franz
BACKGROUND: The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before becoming transmissible to another vertebrate host. A major obstacle an arbovirus has to overcome during its infection cycle inside the mosquito is the midgut escape barrier, representing the exit mechanism arboviruses utilize when disseminating from the midgut...
May 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28503297/cardiovascular-involvement-and-manifestations-of-systemic-chikungunya-virus-infection-a-systematic-review
#5
María Fernanda Alvarez, Adrián Bolívar-Mejía, Alfonso J Rodriguez-Morales, Eduardo Ramirez-Vallejo
BACKGROUND: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. METHODS: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease...
2017: F1000Research
https://www.readbyqxmd.com/read/28483796/imaging-of-viral-neuroinvasion-in-the-zebrafish-reveals-that-sindbis-and-chikungunya-viruses-favour-different-entry-routes
#6
Gabriella Passoni, Christelle Langevin, Nuno Palha, Bryan C Mounce, Valérie Briolat, Pierre Affaticati, Elodie De Job, Jean-Stéphane Joly, Marco Vignuzzi, Maria-Carla Saleh, Philippe Herbomel, Pierre Boudinot, Jean-Pierre Levraud
Alphaviruses, such as chikungunya (CHIKV) and Sindbis virus (SINV), are vector‑borne pathogens that cause acute illnesses in humans and are sometimes associated with neuropathies, especially in infants and elderly patients. Little is known about their entry mechanism in the central nervous system (CNS), even for SINV, which has been used extensively as a model for viral encephalopathies. We previously established a CHIKV infection model in the optically transparent zebrafish larva; here we describe a new SINV infection model in this host...
May 8, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28480053/understanding-the-evolution-and-spread-of-chikungunya-virus-in-the-americas-using-complete-genome-sequences
#7
N S D Sahadeo, O M Allicock, P M De Salazar, A J Auguste, S Widen, B Olowokure, C Gutierrez, A M Valadere, K Polson-Edwards, S C Weaver, C V F Carrington
Local transmission of chikungunya virus (CHIKV) was first detected in the Americas in December 2013, after which it spread rapidly throughout the Caribbean islands and American mainland, causing a major chikungunya fever epidemic. Previous phylogenetic analysis of CHIKV from a limited number of countries in the Americas suggests that an Asian genotype strain was responsible, except in Brazil where both Asian and East/Central/South African (ECSA) lineage strains were detected. In this study, we sequenced thirty-three complete CHIKV genomes from viruses isolated in 2014 from fourteen Caribbean islands, the Bahamas and two mainland countries in the Americas...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28466054/potential-entry-inhibitors-of-the-envelope-protein-e2-of-chikungunya-virus-in-silico-structural-modeling-docking-and-molecular-dynamic-studies
#8
Farah Deeba, Md Zubbair Malik, Irshad Husain Naqvi, Md Shakir Hussain Haider, Zoya Shafat, Priyanka Sinha, Romana Ishrat, Anwar Ahmed, Shama Parveen
Chikungunya fever is an arboviral infection caused by the Chikungunya virus (CHIKV) and is transmitted by Aedes mosquito. The envelope protein (E2) of Chikungunya virus is involved in attachment of virion with the host cell. The present study was conceptualized to determine the structure of E2 protein of CHIKV and to identify the potential viral entry inhibitors. The secondary and tertiary structure of E2 protein was determined using bioinformatics tools. The mutational analysis of the E2 protein suggested that mutations may stabilize or de-stabilize the structure which may affect the structure-function relationship...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28461071/host-oxidative-folding-pathways-offer-novel-anti-chikungunya-virus-drug-targets-with-broad-spectrum-potential
#9
Rose M Langsjoen, Albert J Auguste, Shannan L Rossi, Christopher M Roundy, Heidy N Penate, Maria Kastis, Matthew K Schnizlein, Kevin C Le, Sherry L Haller, Rubing Chen, Stanley J Watowich, Scott C Weaver
Alphaviruses require conserved cysteine residues for proper folding and assembly of the E1 and E2 envelope glycoproteins, and likely depend on host protein disulfide isomerase-family enzymes (PDI) to aid in facilitating disulfide bond formation and isomerization in these proteins. Here, we show that in human HEK293 cells, commercially available inhibitors of PDI or modulators thereof (thioredoxin reductase, TRX-R; endoplasmic reticulum oxidoreductin-1, ERO-1) inhibit the replication of CHIKV chikungunya virus (CHIKV) in vitro in a dose-dependent manner...
April 28, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28459170/clinical-features-and-neurologic-complications-of-children-hospitalized-with-chikungunya-virus-in-honduras
#10
José A Samra, Nancy L Hagood, Andrea Summer, Marco T Medina, Kenton R Holden
The first case of Chikungunya virus in Honduras was identified in 2014. The virus has spread widely across Honduras via the Aedes aegypti mosquito, leading to an outbreak of Chikungunya virus (CHIKV) in 2015 that significantly impacted children. A retrospective chart review of 235 children diagnosed with CHIKV and admitted to the National Autonomous University of Honduras Hospital Escuela (Hospital Escuela) in Tegucigalpa, Honduras, was accomplished with patients who were assessed for clinical features and neurologic complications...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28457785/detection-of-chikungunya-viral-rna-in-mosquito-bodies-on-cationic-q-paper-based-on-innovations-in-synthetic-biology
#11
Lyudmyla G Glushakova, Barry W Alto, Myong Sang Kim, Andrea Bradley, Ozlem Yaren, Steven A Benner
Chikungunya virus (CHIKV) represents a growing and global concern for public health that needs inexpensive and convenient methods to collect mosquitoes as potential carriers so that they can be preserved, stored and transported for later and/or remote analysis. Reported here is a cellulose-based paper, derivatized with quaternary ammonium groups ("Q-paper") that meets these needs. In a series of tests, infected mosquito bodies were squashed directly on Q-paper. Aqueous ammonia was then added on the mosquito bodies to release viral RNA that adsorbed on the cationic surface via electrostatic interactions...
April 27, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28457355/chikungunya-virus
#12
REVIEW
David M Vu, Donald Jungkind, Angelle Desiree LaBeaud
For chikungunya virus (CHIKV), the long-term sequelae from infection are yet ill-defined. The prolonged debilitating arthralgia associated with CHIKV infection has tremendous potential for impacting the global economy and should be considered when evaluating the human burden of disease and the allocation of resources. There is much still unknown about CHIKV and the illnesses that it causes. Developing a better understanding of the pathogenesis of CHIKV infection is a priority and forms the basis for developing effective strategies at infection prevention and disease control...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28435330/first-case-of-imported-chikungunya-infection-in-croatia-2016
#13
Boris Luksic, Nenad Pandak, Edita Drazic-Maras, Svjetlana Karabuva, Mislav Radic, Andrea Babic-Erceg, Ljubo Barbic, Vladimir Stevanovic, Tatjana Vilibic-Cavlek
In recent years, several European countries reported cases of imported chikungunya infection. We present the first imported clinically manifested chikungunya fever in Croatia. A 27-year-old woman returned to Croatia on 21 March 2016, after she stayed in Costa Rica for two months where she had noticed a mosquito bite on her left forearm. Five days after the mosquito bite she developed severe arthralgias, fever and erythematous papular rash. In next few days symptoms gradually subsided. After ten days she felt better, but arthralgias re-appeared accompanied with morning stiffness...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28423140/arboviruses-emerging-in-brazil-challenges-for-clinic-and-implications-for-public-health
#14
Maria Rita Donalisio, André Ricardo Ribas Freitas, Andrea Paula Bruno Von Zuben
Arboviruses have been emerging in different parts of the world due to genetic changes in the virus, alteration of the host and vector population dynamics, or because of anthropogenic environmental factors. These viruses' capacity for adaptation is notable, as well as the likelihood of their emergence and establishment in new geographic areas. In Brazilian epidemiologic scenario, the most common arboviruses are DENV, CHIKV, and ZIKV, although others may spread in the country. Little is yet known of the impact of viral co-circulation, which would theoretically result in more intense viremia or other immunological alterations that could trigger autoimmune diseases, such as Guillain-Barré syndrome...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28414993/chikungunya-virus-infections-time-to-act-time-to-treat
#15
REVIEW
Rana Abdelnabi, Johan Neyts, Leen Delang
Chikungunya virus (CHIKV) is a re-emerging alphavirus that caused massive outbreaks of Chikungunya fever in several countries and regions in Africa, Asia and more recently in Central and South America. An acute CHIKV infection is usually associated with fever and arthritis and it is rarely fatal. However, 15-60% of patients suffer from chronic polyarthralgia for weeks, months or even for several years after the acute infection. There are currently no vaccines or antivirals available for the prevention or treatment of CHIKV infections...
April 14, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28408930/a-case-of-initially-undiagnosed-chikungunya-arthritis-developing-into-chronic-phase-in-a-nonendemic-area
#16
Pui Shan Julia Chan, Moon Ho Leung
This case report described a 40-year-old lady presented with fever, headache, arthralgia, myalgia, and impaired liver function after returning from the Philippines. Chikungunya virus (CHIKV) and dengue serology were negative. Eight weeks after initial presentation, she experienced inflammatory polyarthritis mimic rheumatoid arthritis. This time CHIKV-IgM was detected, together with a >4-fold rise of CHIKV-polyvalent-antibody titre. The first CHIKV-IgM negative sample was reexamined and was CHIKV-PCR positive...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28406093/antiviral-activity-of-nobiletin-against-chikungunya-virus-in-vitro
#17
Shih-Chao Lin, Mei-Chun Chen, Shiming Li, Chi-Chen Lin, Tony T Wang
BACKGROUND: Chikungunya virus (CHIKV), a highly contagious re-emerging virus, is transmitted by infected mosquitoes. CHIKV is prevalent in tropical countries and is continuing to creep farther north into temperate areas. CHIKV is responsible for induction of Chikungunya Fever (CF) and severe joint stiffness with the capability of developing into bilateral and systemic arthralgia or even encephalitis. Despite the high morbidity rate, no approved antiviral drug is available. Therefore, an anti-CHIKV therapy is necessary to control this disease...
April 13, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28404855/genome-wide-screening-uncovers-the-significance-of-n-sulfation-of-heparan-sulfate-as-a-host-cell-factor-for-chikungunya-virus-infection
#18
Atsushi Tanaka, Uranan Tumkosit, Shota Nakamura, Daisuke Motooka, Natsuko Kishishita, Thongkoon Priengprom, Areerat Sa-Ngasang, Taroh Kinoshita, Naokazu Takeda, Yusuke Maeda
The molecular mechanisms underlying chikungunya virus (CHIKV) infection are poorly characterized. In this study, we analyzed the host factors involved in CHIKV infection using genome-wide screening. Human haploid HAP1 cells, into which an exon-trapping vector was introduced, were challenged with a vesicular stomatitis virus pseudotype bearing the CHIKV E3-E1 envelope proteins. Analysis of genes enriched in the cells resistant to the pseudotyped virus infection unveiled a critical role of N-sulfation of heparan sulfate (HS) for the infectivity of a clinically isolated CHIKV Thai #16856 strain to HAP1 cells...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28390873/chikungunya-virus-nsp4-rna-dependent-rna-polymerase-core-domain-displays-detergent-sensitive-primer-extension-and-terminal-adenylyltransferase-activities
#19
Ming Wei Chen, Yaw Bia Tan, Jie Zheng, Yongqian Zhao, Bee Ting Lim, Tobias Cornvik, Julien Lescar, Lisa Fong Poh Ng, Dahai Luo
Chikungunya virus (CHIKV) is an important arboviral infectious agent in tropical and subtropical regions, often causing persistent and debilitating disease. The viral enzyme non-structural protein 4 (nsP4), as RNA-dependent RNA polymerase (RdRP), catalyzes the formation of negative-sense, genomic and subgenomic viral RNAs. Here we report a truncated nsP4 construct that is soluble, stable and purified recombinantly from Escherichia coli. Sequence analyses and homology modelling indicate that all necessary RdRP elements are included...
April 5, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28388320/entomological-investigations-during-early-stages-of-a-chikungunya-outbreak-in-the-united-states-virgin-islands-2014
#20
Joan L Kenney, Kristen L Burkhalter, Mariah L Scott, Janet McAllister, Francine E Lang, Stevie Webster, Dwayne J Maduro, Juanita Johannes, Alistair Liburd, John-Paul Mutebi
During the 2014 chikungunya (CHIK) outbreak in the Caribbean, we performed entomological surveys on 3 United States Virgin Islands (USVI): St. Croix, St. Thomas, and St. John. We aimed to evaluate the potential for chikungunya virus (CHIKV) transmission in the USVI. The surveys took place between June 19, 2014, and June 29, 2014, during the dry season in USVI. A total of 1,929 adult mosquitoes belonging to 4 species- Culex quinquefasciatus (68.4%), Aedes aegypti (29.7%), Ae. mediovittatus (1.3%), and Ae. sollicitans (<1%)-were detected...
March 2017: Journal of the American Mosquito Control Association
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