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https://www.readbyqxmd.com/read/29434399/anti-viral-activities-of-oroxylum-indicum-extracts-on-chikungunya-virus-infection
#1
Syuhadaratul Aini Mohamat, Rafidah Hanim Shueb, Nor Fazila Che Mat
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that poses a threat to human worldwide. Driven by the lack of approved medication and vaccination, research on anti-Chikungunya agents has received great attention. In an effort to determine potential inhibitor of CHIKV, this study aimed at investigating the potential anti-viral activity of Oroxylum indicum extracts towards CHIKV-infected Vero cells. The virucidal, pre- and post-treatment effects of O. indicum were evaluated, using the maximum non-toxic dose of O...
March 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29425199/evidence-of-previous-but-not-current-transmission-of-chikungunya-virus-in-southern-and-central-vietnam-results-from-a-systematic-review-and-a-seroprevalence-study-in-four-locations
#2
Tran Minh Quan, Huynh Thi Phuong, Nguyen Ha Thao Vy, Nguyen Thi Le Thanh, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Pham Ngoc Dung, Nguyen Van Vinh Chau, Maciej F Boni, Hannah E Clapham
BACKGROUND: Arbovirus infections are a serious concern in tropical countries due to their high levels of transmission and morbidity. With the outbreaks of chikungunya (CHIKV) in surrounding regions in recent years and the fact that the environment in Vietnam is suitable for the vectors of CHIKV, the possibility of transmission of CHIKV in Vietnam is of great interest. However, information about CHIKV activity in Vietnam remains limited. METHODOLOGY: In order to address this question, we performed a systematic review of CHIKV in Vietnam and a CHIKV seroprevalence survey...
February 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29424106/seroprevalence-of-selected-flaviviruses-in-free-living-and-captive-capuchin-monkeys-in-the-state-of-pernambuco-brazil
#3
E F de Oliveira-Filho, R A S Oliveira, D R A Ferreira, P O Laroque, L J Pena, M M Valença-Montenegro, R A Mota, L H V G Gil
Mosquito-borne diseases such as dengue, yellow fever and, more recently, Chikungunya virus (CHIKV) and Zika virus (ZIKV) have a great impact in the public health. In addition, the presence of such viruses might have an impact on wild animal conservation as well as their possible role as animal reservoir. Here, we performed a serological survey searching for antibodies against a panel of flaviviruses [ZIKV, Dengue virus (DENV), Yellow Fever virus (YFV), West Nile virus (WNV), Saint Louis Encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV)] using plaque reduction neutralization test (PRNT90 ) in both free-ranging and captive capuchin monkeys (Sapajus flavius and Sapajus libidinosus)...
February 8, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29415070/evidence-for-chikungunya-and-dengue-transmission-in-quelimane-mozambique-results-from-an-investigation-of-a-potential-outbreak-of-chikungunya-virus
#4
Vánio André Mugabe, Sadia Ali, Imelda Chelene, Vanessa Onofre Monteiro, Onélia Guiliche, Argentina Felisbela Muianga, Flora Mula, Virgílio António, Inocêncio Chongo, John Oludele, Kerstin Falk, Igor A Paploski, Mitermayer G Reis, Uriel Kitron, Beate M Kümmerer, Guilherme S Ribeiro, Eduardo Samo Gudo
BACKGROUND: In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane. METHODS/PRINCIPAL FINDINGS: From February to June 2016, we conducted a cross-sectional study enrolling febrile patients attending five outpatient health units in Quelimane...
2018: PloS One
https://www.readbyqxmd.com/read/29414182/laboratory-findings-in-zika-infection-the-experience-of-a-reference-centre-in-north-west-italy
#5
Elisa Burdino, Maria Grazia Milia, Tiziano Allice, Gabriella Gregori, Tina Ruggiero, Guido Calleri, Filippo Lipani, Anna Lucchini, Giulietta Venturi, Giovanni Di Perri, Valeria Ghisetti
BACKGROUND: Zika virus (ZIKV) remains a public health concern due to its association with fetal malformation and neurologic disease. OBJECTIVE: To report a reference centre experience on ZIKA virus (ZIKV) infection in travelers from epidemic countries from January 1 to September, 30, 2016 in Italy North-West (a geographic area covering 4.424 million inhabitants, corresponding to almost 73% of Italy North-West area). STUDY DESIGN: One hundred and twelve febrile travelers were studied to rule out a tropical fever [e...
January 30, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29410416/broad-and-long-lasting-immune-protection-against-various-chikungunya-genotypes-demonstrated-by-participants-in-a-cross-sectional-study-in-a-cambodian-rural-community
#6
Heidi Auerswald, Camille Boussioux, Saraden In, Sokthearom Mao, Sivuth Ong, Rekol Huy, Rithea Leang, Malen Chan, Veasna Duong, Sowath Ly, Arnaud Tarantola, Philippe Dussart
Chikungunya virus (CHIKV) is an alphavirus circulating worldwide. Its presence in Asia has been reported since the 1950s, constituting the Asian genotype. Since 2005, strains from the Eastern, Central, and Southern African (ECSA) genotype have caused several outbreaks across Asia. Viruses from the ECSA genotype were also detected in Cambodia in late 2011 and led to an outbreak in a rural community in 2012. A former investigation from 2012 found a higher risk of infection in people younger than 40 years, suggesting a pre-existing herd immunity in the older Cambodian population due to infection with an Asian genotype...
February 7, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29406692/inhibition-of-the-replication-of-different-strains-of-chikungunya-virus-by-3-aryl-1-2-3-triazolo-4-5-d-pyrimidin-7-6h-ones
#7
Asier Gómez-SanJuan, Ana-María Gamo, Leen Delang, Alfonso Pérez-Sánchez, Siti Naqiah Amrun, Rana Abdelnabi, Sofie Jacobs, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Lisa F P Ng, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez
The re-emergence of chikungunya virus (CHIKV) is a serious global health threat. CHIKV is an alphavirus that is transmitted to humans by Aedes mosquitoes; therefore, their wide distribution significantly contributes to the globalization of the disease. Unfortunately, no effective antiviral drugs are available. We have identified a series of 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective inhibitors of CHIKV replication. New series of compounds have now been synthesized with the aim to improve their physicochemical properties and to potentiate the inhibitory activity against different CHIKV strains...
February 14, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29405105/an-assessment-of-household-and-individual-level-mosquito-prevention-methods-during-the-chikungunya-virus-outbreak-in-the-united-states-virgin-islands-2014-2015
#8
Leora R Feldstein, Ali Rowhani-Rahbar, J Erin Staples, M Elizabeth Halloran, Esther M Ellis
Recent large-scale chikungunya virus (CHIKV) and Zika virus epidemics in the Americas pose a growing public health threat. Given that mosquito bite prevention and vector control are the main prevention methods available to reduce transmission of these viruses, we assessed adherence to these methods in the United States Virgin Islands (USVI). We interviewed 334 USVI residents between December 2014 and February 2015 to measure differences in mosquito prevention practices by gender, income, presence of CHIKV symptoms, and age...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29404420/limited-evidence-for-infection-of-urban-and-peri-urban-nonhuman-primates-with-zika-and-chikungunya-viruses-in-brazil
#9
Andres Moreira-Soto, Ianei de Oliveira Carneiro, Carlo Fischer, Marie Feldmann, Beate M Kümmerer, Nama Santos Silva, Uilton Góes Santos, Breno Frederico de Carvalho Dominguez Souza, Fernanda de Azevedo Liborio, Mônica Mafra Valença-Montenegro, Plautino de Oliveira Laroque, Fernanda Rosa da Fontoura, Alberto Vinicius Dantas Oliveira, Christian Drosten, Xavier de Lamballerie, Carlos Roberto Franke, Jan Felix Drexler
Chikungunya virus (CHIKV) and Zika virus (ZIKV) emerged in the Americas in 2013. Limited antigenic variability of CHIKV and ZIKV may restrict urban transmission cycles due to population protective immunity. In Africa, sylvatic transmission cycles involving nonhuman primates (NHP) are known for CHIKV and ZIKV, causing cyclic reemergence in humans. To evaluate whether sylvatic cycles can be expected in Latin America, we tested 207 NHP collected between 2012 and 2017 in urban and peri-urban settings in Brazil for infection with ZIKV and CHIKV...
January 2018: MSphere
https://www.readbyqxmd.com/read/29395729/antiviral-immunity-and-virus-mediated-antagonism-in-disease-vector-mosquitoes
#10
REVIEW
Glady Hazitha Samuel, Zach N Adelman, Kevin M Myles
More than 100 pathogens, spanning multiple virus families, broadly termed 'arthropod-borne viruses (arboviruses)' have been associated with human and/or animal diseases. These viruses persist in nature through transmission cycles that involve alternating replication in susceptible vertebrate and invertebrate hosts. Collectively, these viruses are among the greatest burdens to global health, due to their widespread prevalence, and the severe morbidity and mortality they cause in human and animal hosts. Specific examples of mosquito-borne pathogens include Zika virus (ZIKV), West Nile virus (WNV), dengue virus serotypes 1-4 (DENV 1-4), Japanese encephalitis virus (JEV), yellow fever virus (YFV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV)...
January 29, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29394382/a-summary-of-the-imported-cases-of-chikungunya-fever-in-japan-from-2006-to-june-2016
#11
Eri Nakayama, Shigeru Tajima, Akira Kotaki, Ken-Ichi Shibasaki, Kentaro Itokawa, Kengo Kato, Akifumi Yamashita, Tsuyoshi Sekizuka, Makoto Kuroda, Takashi Tomita, Masayuki Saijo, Tomohiko Takasaki
Background: Due to the huge 2-way human traffic between Japan and Chikungunya (CHIK) fever-endemic regions, 89 imported cases of CHIK fever were confirmed in Japan from January 2006 to June 2016. Fifty-four of 89 cases were confirmed virologically and serologically at the National Institute of Infectious Diseases, Japan and we present the demographic profiles of the patients and the phylogenetic features of 14 CHIK virus (CHIKV) isolates. Methods: Patients were diagnosed with CHIK fever by a combination of virus isolation, viral RNA amplification, IgM antibody-, IgG antibody-, and/or neutralizing antibody detection...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29386359/zika-virus-related-neurotropic-flaviviruses-infect-human-placental-explants-and-cause-fetal-demise-in-mice
#12
Derek J Platt, Amber M Smith, Nitin Arora, Michael S Diamond, Carolyn B Coyne, Jonathan J Miner
Although Zika virus (ZIKV) infection in pregnant women can cause placental damage, intrauterine growth restriction, microcephaly, and fetal demise, these disease manifestations only became apparent in the context of a large epidemic in the Americas. We hypothesized that ZIKV is not unique among arboviruses in its ability to cause congenital infection. To evaluate this, we tested the capacity of four emerging arboviruses [West Nile virus (WNV), Powassan virus (POWV), chikungunya virus (CHIKV), and Mayaro virus (MAYV)] from related (flavivirus) and unrelated (alphavirus) genera to infect the placenta and fetus in immunocompetent, wild-type mice...
January 31, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29382880/antibody-mediated-enhancement-aggravates-chikungunya-virus-infection-and-disease-severity
#13
Fok-Moon Lum, Thérèse Couderc, Bing-Shao Chia, Ruo-Yan Ong, Zhisheng Her, Angela Chow, Yee-Sin Leo, Yiu-Wing Kam, Laurent Rénia, Marc Lecuit, Lisa F P Ng
The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but antibodies present at sub-neutralizing concentrations can also augment virus infection that exacerbates disease severity. To explore this occurrence, CHIKV infection was investigated in the presence of CHIKV-specific antibodies in both primary human cells and a murine macrophage cell line, RAW264...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382300/co-circulation-and-simultaneous-co-infection-of-dengue-chikungunya-and-zika-viruses-in-patients-with-febrile-syndrome-at-the-colombian-venezuelan-border
#14
Marlen Yelitza Carrillo-Hernández, Julian Ruiz-Saenz, Lucy Jaimes Villamizar, Sergio Yebrail Gómez-Rangel, Marlen Martínez-Gutierrez
BACKGROUND: In Colombia, the dengue virus (DENV) has been endemic for decades, and with the recent entry of the chikungunya virus (CHIKV) (2014) and the Zika virus (ZIKV) (2015), health systems are overloaded because the diagnosis of these three diseases is based on clinical symptoms, and the three diseases share a symptomatology of febrile syndrome. Thus, the objective of this study was to use molecular methods to identify their co-circulation as well as the prevalence of co-infections, in a cohort of patients at the Colombian-Venezuelan border...
January 30, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29363451/case-report-an-acute-chikungunya-infection-and-a-recent-secondary-dengue-infection-in-a-peripartum-case-in-ecuador
#15
Daniel F Farrell, Christina D Lupone, Aileen Kenneson, Cinthya Cueva, Naveed Heydari, Julio H Barzallo Aguilera, Mark Polhemus, Timothy P Endy, Anna M Stewart-Ibarra
Dengue virus (DENV) and chikungunya virus (CHIKV) are transmitted by the same mosquito vectors and now co-circulate in many parts of the world; however, coinfections and serial infections are not often diagnosed or reported. A 38-week pregnant woman was admitted to the hospital with a diagnosis of suspected DENV and CHIKV in southern coastal Ecuador. The pregnancy was complicated by mild polyhydramnios and fetal tachycardia, and a healthy newborn was born. The patient was positive for a recent secondary DENV infection (Immunoglobulin M and Immunoglobulin G positive) and an acute CHIKV infection (real-time reverse transcriptase polymerase chain reaction positive) (Asian genotype)...
January 22, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29362259/prognostic-factors-of-inhospital-death-in-elderly-patients-a-time-to-event-analysis-of-a-cohort-study-in-martinique-french-west-indies
#16
Lidvine Godaert, Seendy Bartholet, Fréderique Dorléans, Fatiha Najioullah, Sebastien Colas, Jean-Luc Fanon, André Cabié, Raymond Césaire, Moustapha Dramé
OBJECTIVE: The primary objective was to identify predictive factors of inhospital death in a population of patients aged 65 years or older hospitalised with Chikungunya virus (CHIKV) infection. The secondary aim was to develop and validate a predictive score for inhospital death based on the predictors identified. DESIGN: Longitudinal retrospective study from January to December 2014. SETTING: University Hospital of Martinique. PARTICIPANTS: Patients aged ≥65 years, admitted to any clinical ward and who underwent reverse transcription PCR testing for CHIKV infection...
January 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29361204/lessons-learned-from-chikungunya-in-the-americas
#17
EDITORIAL
Jonathan J Miner, Deborah J Lenschow
In 2013, chikungunya virus (CHIKV) arrived in the Western Hemisphere, spreading like wildfire across the Islands of the Caribbean, Mexico, Central America, and South America, resulting in ~3 million infections (1). Similar to historical outbreaks in the Eastern Hemisphere, CHIKV spread quickly in a population without pre-existing immunity to CHIKV. This article is protected by copyright. All rights reserved.
January 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29360072/-dengue-zika-chikungunya-and-the-development-of-vaccines
#18
Isabel N Kantor
Dengue (DENV), zika (ZIKV) and chikungunya (CHIKV), three arbovirosis transmitted by Aedes mosquitoes, have spread in recent decades in humid tropical and subtropical zones. Dengue is epidemic in subtropical areas of Argentina. DENV infection confers lasting immunity against the infecting serotype but increases the risk of serious disease upon reinfection by any of the other three. The recombinant tetravalent vaccine Dengvaxia® prevents severe dengue and hospitalization in seropositive subjects. In 2017, Dengvaxia was approved in Argentina, for ages 9 to 45, but is not included in the national vaccination calendar...
2018: Medicina
https://www.readbyqxmd.com/read/29354659/chikungunya-outbreak-in-kedougou-southeastern-senegal-in-2009-2010
#19
Abdourahmane Sow, Oumar Faye, Mawlouth Diallo, Diawo Diallo, Rubing Chen, Ousmane Faye, Cheikh T Diagne, Mathilde Guerbois, Manfred Weidmann, Youssoupha Ndiaye, Cheikh Sadibou Senghor, Abdourahmane Faye, Ousmane M Diop, Bakary Sadio, Oumar Ndiaye, Douglas Watts, Kathryn A Hanley, Anta T Dia, Denis Malvy, Scott C Weaver, Amadou Alpha Sall
Background: In Senegal, Chikungunya virus (CHIKV), which is an emerging mosquito-borne alphavirus, circulates in a sylvatic and urban/domestic cycle and has caused sporadic human cases and epidemics since 1960s. However, the real impact of the CHIKV sylvatic cycle in humans and mechanisms underlying its emergence still remains unknown. Methodology: One thousand four hundred nine suspect cases of CHIKV infection, recruited from 5 health facilities located in Kedougou region, south-eastern Senegal, between May 2009 to March 2010, together with 866 serum samples collected from schoolchildren from 4 elementary schools in May and November 2009 from Kedougou were screened for anti-CHIKV immunoglobulin (Ig)M antibodies and, when appropriate, for viral nucleic acid by real-time polymerase chain reaction (rPCR) and virus isolation...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29352633/current-concerns-and-perspectives-on-zika-virus-co-infection-with-arboviruses-and-hiv
#20
REVIEW
Hussin A Rothan, Mehdi R M Bidokhti, Siddappa N Byrareddy
Dissemination of vector-borne viruses, such as Zika virus (ZIKV), in tropical and sub-tropical regions has a complicated impact on the immunopathogenesis of other endemic viruses such as dengue virus (DENV), chikungunya virus (CHIKV) and human immunodeficiency virus (HIV). The consequences of the possible co-infections with these viruses have specifically shown significant impact on the treatment and vaccination strategies. ZIKV is a mosquito-borne flavivirus from African and Asian lineages that causes neurological complications in infected humans...
January 16, 2018: Journal of Autoimmunity
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