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https://www.readbyqxmd.com/read/29206195/psychological-distress-and-zika-dengue-and-chikungunya-symptoms-following-the-2016-earthquake-in-bah%C3%A3-a-de-car%C3%A3-quez-ecuador
#1
Anna M Stewart-Ibarra, Anita Hargrave, Avriel Diaz, Aileen Kenneson, David Madden, Moory M Romero, Juan Pablo Molina, David Macias Saltos
On 16 April 2016, a 7.8 magnitude earthquake struck coastal Ecuador, resulting in significant mortality and morbidity, damages to infrastructure, and psychological trauma. This event coincided with the first outbreak of Zika virus (ZIKV) and co-circulation with dengue virus (DENV) and chikungunya virus (CHIKV). We tested whether the degree of psychological distress was associated with the presence of suspected DENV, CHIKV, ZIKV (DCZ) infections three months after the earthquake. In July 2016, 601 household members from four communities in Bahía de Caráquez, Manabí Province, Ecuador, were surveyed in a post-disaster health evaluation...
December 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29194359/chikungunya-virus-pathophysiology-mechanism-and-modeling
#2
REVIEW
Vaishnavi K Ganesan, Bin Duan, St Patrick Reid
Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic waves. In the past decade and a half, the disease has resurged in several countries around the globe, with outbreaks becoming increasingly severe. Though CHIKV was first isolated in 1952, there remain significant gaps in knowledge of CHIKV biology, pathogenesis, transmission, and mechanism. Diagnosis is largely simplified and based on symptoms, while treatment is supportive rather than curative. Here we present an overview of the disease, the challenges that lie ahead for future research, and what directions current studies are headed towards, with emphasis on improvement of current animal models and potential use of 3D models...
December 1, 2017: Viruses
https://www.readbyqxmd.com/read/29191474/chikungunya-related-erosive-arthritis-case-report-and-literature-review
#3
Francisco Castro-Domínguez, Tarek Carlos Salman-Monte, Fabiola Ojeda, Patricia Corzo, Irene Carrión-Barberá, Ivan Camilo Garcia-Duitama, Jordi Monfort
Chikungunya virus infection (CHIKV) is associated with joint involvement in half of the cases. This can lead to erosive arthritis which, given the high intervariability of clinical and serological presentations, and the probable role of genetic conditioning in the severity and chronification of the condition, represents a great diagnostic and therapeutic challenge. There is an important lack of scientific evidence that would enable us to characterize the variability of the patient and choose the most appropriate approach...
November 27, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29188427/recent-progress-on-chikungunya-virus-research
#4
REVIEW
Wenxi An, Ningning Ge, Yilin Cao, Jin Sun, Xia Jin
Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world. After decades of sporadic outbreaks, it re-emerged in Africa, Asia, India Ocean and America suddenly, causing major regional epidemics recently and becoming a notable global health problem. Infection by CHIKV results in a spectrum of clinical diseases including an acute self-limiting febrile illness in most individuals, a chronic phase of recurrent join pain in a proportion of patients, and long-term arthralgia for months to years for the unfortunate few...
November 28, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/29185115/the-synergistic-effect-of-nsp2-l618-nsp3-r117-and-e2-k187-on-the-large-plaque-phenotype-of-chikungunya-virus
#5
Benjawan Thoka, Thitigun Jaimipak, Supachoke Onnome, Sutee Yoksan, Sukathida Ubol, Rojjanaporn Pulmanausahakul
Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is the etiological agent of chikungunya fever. CHIKV re-emerged from 2004 onwards, and subsequently caused major outbreaks in many parts of the world including the Indian Ocean islands, Asia, and the Americas. In this study, a large plaque variant of CHIKV isolated from patient in Thailand was subjected to repeated cycles of plaque-purification in Vero cells. The resulting virus produced homogenous large plaques and showed a more pathogenic phenotype than the parental wild-type CHIKV...
November 28, 2017: Virus Genes
https://www.readbyqxmd.com/read/29182664/differential-inhibitory-and-activating-nk-cell-receptor-levels-and-nk-nkt-like-cell-functionality-in-chronic-and-recovered-stages-of-chikungunya
#6
Subrat Thanapati, Mohini A Ganu, Anuradha S Tripathy
The role of natural killer (NK; CD3-CD56+)/NKT (CD3+CD56+)-like cells in chikungunya virus (CHIKV) disease progression/recovery remains unclear. Here, we investigated the expression profiles and function of NK and NKT-like cells from 35 chronic chikungunya patients, 30 recovered individuals, and 69 controls. Percentage of NKT-like cells was low in chronic chikungunya patients. NKp30+, CD244+, DNAM-1+, and NKG2D+ NK cell percentages were also lower (MFI and/or percentage), while those of CD94+ and NKG2A+ NKT-like cells were higher (MFI and/or percentage) in chronic patients than in recovered subjects...
2017: PloS One
https://www.readbyqxmd.com/read/29165625/evidence-of-chikungunya-virus-circulation-in-the-terai-region-of-nepal-in-2014-and-2015
#7
Kishor Pandey, Basu Dev Pandey, Ram Rekha Chaurasiya, Mahesh Thakur, Biswas Neupane, Yogendra Shah, Mya Myat Ngwe Tun, Kouichi Morita
Background: Chikungunya virus (CHIKV) infection is an emerging viral disease in Nepal, with the reported by our laboratories in 2013. Because of the similarity in signs and symptoms to dengue virus (DENV) and misdiagnosis, the under-reporting of CHIKV infection in DENV-endemic areas of Nepal is very common. The aim of the present study is to identify CHIKV infection among patients with febrile illness during the 2014-2015 outbreaks. Methods: A total of 219 serum samples were tested for CHIKV and DENV by using enzyme-linked immunosorbent assays (ELISAs) to detect immunoglobulin M (IgM) and IgG antibodies, with confirmation by a 50% focal reduction neutralization test (FRNT50)...
November 20, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29161110/biotechnological-applications-of-an-insect-specific-alphavirus
#8
Jesse H Erasmus, Scott C Weaver
The coupling of viral and arthropod host diversity, with evolving methods of virus discovery, has resulted in the identification and classification of a growing number of novel insect-specific viruses (ISVs) that appear to be evolutionarily related to many human pathogens but have either lost or have yet to gain the ability to replicate in vertebrates. The discovery of ISVs has raised many questions as to the origin and evolution of many human pathogenic viruses and points to the role that arthropods may play in this evolutionary process...
November 21, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29156857/a-study-of-the-chikungunya-virus-in-humans-in-turkey
#9
Tuğba Atalay, Sedat Kaygusuz, Ahmet Kürşat Azkur
Background/aim: The chikungunya virus (CHIKV) is a mosquito-borne disease and has recently been causing explosive outbreaks. The CHIKV has spread throughout all continents. Although the first chikungunya case imported from India to Turkey was reported in 2012, there is no detailed epidemiologic study in Turkey yet. The aim of this study was to investigate the seroprevalence of the CHIKV in Turkey. Materials and methods: ELISA was used to screen 500 random serum samples of healthy people collected from Kırıkkale, which is located in central Anatolia in Turkey...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29149964/chikungunya-infection-in-solid-organ-transplant-recipients
#10
E S Girão, B G Rodrigues Dos Santos, E S do Amaral, P E G Costa, K B Pereira, A H de Araujo Filho, E B Hyppolito, M U Mota, L C B F Marques, C M Costa de Oliveira, S L da Silva, J H P Garcia, P F C B C Fernandes
BACKGROUND: Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Few data exist regarding the clinical characteristics of CHIKV infections in this population. We report the first case series of CHIKV infection in SOT recipients...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29145452/behavioral-climatic-and-environmental-risk-factors-for-zika-and-chikungunya-virus-infections-in-rio-de-janeiro-brazil-2015-16
#11
Trevon L Fuller, Guilherme Calvet, Camila Genaro Estevam, Jussara Rafael Angelo, Gbenga J Abiodun, Umme-Aiman Halai, Bianca De Santis, Patricia Carvalho Sequeira, Eliane Machado Araujo, Simone Alves Sampaio, Marco Cesar Lima de Mendonça, Allison Fabri, Rita Maria Ribeiro, Ryan Harrigan, Thomas B Smith, Claudia Raja Gabaglia, Patrícia Brasil, Ana Maria Bispo de Filippis, Karin Nielsen-Saines
The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/29145171/host-target-based-approaches-against-arboviral-diseases
#12
Rebeca Froes Rocha, Juliana Lemos Del Sarto, Rafael Elias Marques, Vivian Vasconcelos Costa, Mauro Martins Teixeira
In the 20th century, socioeconomic and environmental changes facilitated the reintroduction of mosquitoes in developing cities, resulting in the reintroduction of mosquito-borne viral diseases and the dispersal of their causative agents in a worldwide scale. Recurrent outbreaks of arboviral diseases are being reported, even in regions without a previous history of arboviral disease transmission. Of note, arboviral infections represented approximately 30% of all emerging vector-borne diseases of the last decade...
November 27, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/29138302/disruption-of-the-opal-stop-codon-attenuates-chikungunya-virus-induced-arthritis-and-pathology
#13
Jennifer E Jones, Kristin M Long, Alan C Whitmore, Wes Sanders, Lance R Thurlow, Julia A Brown, Clayton R Morrison, Heather Vincent, Kayla M Peck, Christian Browning, Nathaniel Moorman, Jean K Lim, Mark T Heise
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean islands and the Americas that caused more than 1 million cases of viral arthralgia. Despite the major impact of CHIKV on global health, viral determinants that promote CHIKV-induced disease are incompletely understood. Most CHIKV strains contain a conserved opal stop codon at the end of the viral nsP3 gene...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#14
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29136650/emerging-and-reemerging-arboviruses-a-new-threat-in-eastern-peru
#15
Carlos Alva-Urcia, Miguel Angel Aguilar-Luis, Carlos Palomares-Reyes, Wilmer Silva-Caso, Luis Suarez-Ognio, Pablo Weilg, Carlos Manrique, Fernando Vasquez-Achaya, Luis J Del Valle, Juana Del Valle-Mendoza
BACKGROUND: Arboviral diseases are one of the most common causes of acute febrile illness (AFI) and a significant health problem in South America. In Peru, laboratory etiologic identification of these infections occurs in less than 50% of cases, leading to underdiagnoses of important emerging arboviruses. AIM: To assess the prevalence of the Dengue (DENV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and Zika (ZIKV) viruses in patients with acute febrile illness from Puerto Maldonado (Peru)...
2017: PloS One
https://www.readbyqxmd.com/read/29135829/chikungunya-virus-infections-among-infants-who-classification-not-applicable
#16
Veronique van Keulen, Minke Huibers, Meindert Manshande, Michaël Boele van Hensbroek, Linda van Rooij
Chikungunya virus (ChikV) caused an epidemic on Curaçao in 2014-2015. Infants are highly at risk for clinical syndromes as sepsis-like illness and central nervous system disease. Clinical recognition is important if laboratory test, polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), are not available. The World Health Organization (WHO) created criteria for identification of probable ChikV. None of the studied infants met these criteria. We believe the WHO suggested criteria should be modified for infants...
November 11, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29116243/evaluation-of-a-range-of-mammalian-and-mosquito-cell-lines-for-use-in-chikungunya-virus-research
#17
Grace C Roberts, Carsten Zothner, Roland Remenyi, Andres Merits, Nicola J Stonehouse, Mark Harris
Chikungunya virus (CHIKV) is becoming an increasing global health issue which has spread across the globe and as far north as southern Europe. There is currently no vaccine or anti-viral treatment available. Although there has been a recent increase in CHIKV research, many of these in vitro studies have used a wide range of cell lines which are not physiologically relevant to CHIKV infection in vivo. In this study, we aimed to evaluate a panel of cell lines to identify a subset that would be both representative of the infectious cycle of CHIKV in vivo, and amenable to in vitro applications such as transfection, luciferase assays, immunofluorescence, western blotting and virus infection...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113976/co-infection-with-chikungunya-virus-alters-trafficking-of-pathogenic-cd8-t-cells-into-the-brain-and-prevents-plasmodium-induced-neuropathology
#18
Teck-Hui Teo, Shanshan W Howland, Carla Claser, Sin Yee Gun, Chek Meng Poh, Wendy Wl Lee, Fok-Moon Lum, Lisa Fp Ng, Laurent Rénia
Arboviral diseases have risen significantly over the last 40 years, increasing the risk of co-infection with other endemic disease such as malaria. However, nothing is known about the impact arboviruses have on the host response toward heterologous pathogens during co-infection. Here, we investigate the effects of Chikungunya virus (CHIKV) co-infection on the susceptibility and severity of malaria infection. Using the Plasmodium berghei ANKA (PbA) experimental cerebral malaria (ECM) model, we show that concurrent co-infection induced the most prominent changes in ECM manifestation...
November 7, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29108009/zika-virus-displacement-by-a-chikungunya-outbreak-in-recife-brazil
#19
Tereza Magalhaes, Cynthia Braga, Marli T Cordeiro, Andre L S Oliveira, Priscila M S Castanha, Ana Paula R Maciel, Nathalia M L Amancio, Pollyanne N Gouveia, Valter J Peixoto-da-Silva, Thaciana F L Peixoto, Helena Britto, Priscilla V Lima, Andreza R S Lima, Kerstin D Rosenberger, Thomas Jaenisch, Ernesto T A Marques
BACKGROUND: Several arboviruses, including dengue virus (DENV), Zika virus (ZIKV) and chikungunya virus (CHIKV), transmitted by Aedes mosquitoes, circulate in northeast Brazil. Diseases caused by these viruses are of great public health relevance, however, their epidemiological features in areas where the three viruses co-circulate are scarce. Here, we present analyses of molecular and serological diagnostics in a prospective study of acute febrile patients recruited from May 2015 to May 2016 in Recife, Brazil...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29100064/outbreak-of-chikungunya-virus-in-a-vulnerable-population-of-sergipe-brazil-a-molecular-and-serological-survey
#20
Marielton Dos Passos Cunha, Cliomar Alves Dos Santos, Daniel Ferreira de Lima Neto, Alessandra Soares Schanoski, Shahab Zaki Pour, Saulo Duarte Passos, Mércia Simone Feitosa de Souza, Danuza Duarte Costa, Paolo Marinho de Andrade Zanotto
BACKGROUND: Chikungunya virus (CHIKV) is a re-emerging arbovirus that is causing outbreaks in several countries of the Americas. The virus was introduced in Brazil in 2014, and since then, several Brazilian states have notified autochthonous cases. OBJECTIVES: Provide additional evidence on a CHIKV outbreak and an outline of the laboratory and clinical profile of symptomatic patients in Sergipe, Brazil. STUDY DESIGN: In February 2016, we collected 142 serum samples from symptomatic patients for arboviruses in Sergipe, Brazil...
October 31, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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