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https://www.readbyqxmd.com/read/29228000/an-in-vivo-assessment-of-the-cholesterol-lowering-efficacy-of-lactobacillus-plantarum-ecgc-13110402-in-normal-to-mildly-hypercholesterolaemic-adults
#1
Adele Costabile, Ivan Buttarazzi, Sofia Kolida, Sara Quercia, Jessica Baldini, Jonathan R Swann, Patrizia Brigidi, Glenn R Gibson
Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries, with elevated blood cholesterol an established risk factor. Total plasma cholesterol reduction in populations suffering from primary hypercholesterolemia may lower CHD incidence. This study investigated the cholesterol reducing capacity of Lactobacillus plantarum ECGC 13110402, a strain selected for its high bile salt hydrolase activity, in 49 normal to mildly hypercholesterolaemic adults. Primary efficacy outcomes included effect on blood lipids (total cholesterol (TC), low density lipoproteins (LDL-C), high density lipoproteins (HDL-C) and triacylgycerides (TAG), inflammatory biomarkers and occurrence/severity of gastrointestinal side effects to establish safety and tolerance of the intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29223736/transepithelial-transfer-of-phenanthrene-but-not-of-benzo-a-pyrene-is-inhibited-by-fatty-acids-in-the-proximal-intestine-of-rainbow-trout-oncorhynchus-mykiss
#2
Stefan de Gelder, Henrik Sundh, Thamar N M Pelgrim, Josef D Rasinger, Lotte van Daal, Gert Flik, Marc H G Berntssen, Peter H M Klaren
The inclusion of vegetable oils in aquafeeds introduces contaminating polycyclic aromatic hydrocarbons (PAHs) in salmonids. Since lipophilic PAHs solubilize in micelles composed of lipids, bile salts and fatty acids, dietary lipid composition can alter intestinal transepithelial PAH transfer. We studied the uptake of two PAHs, viz. benzo[a]pyrene (BaP) and phenanthrene (PHE), in rainbow trout (Oncorhynchus mykiss) intestine. We also investigated the effects of two fatty acids, viz. fish oil-derived eicosapentaenoic acid (EPA, 20:5n-3) and vegetable oil-derived oleic acid (18:1n-9) on intestinal uptake...
December 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29218582/application-of-fluorescence-emission-for-characterization-of-albendazole-and-ricobendazole-micellar-systems-elucidation-of-the-molecular-mechanism-of-drug-solubilization-process
#3
Josefina Priotti, Darío Leonardi, Guillermo Pico, María C Lamas
Albendazole (ABZ) and ricobendazole (RBZ) are referred to as class II compounds in the Biopharmaceutical Classification System. These drugs exhibit poor solubility, which profoundly affects their oral bioavailability. Micellar systems are excellent pharmaceutical tools to enhance solubilization and absorption of poorly soluble compounds. Polysorbate 80 (P80), poloxamer 407 (P407), sodium cholate (Na-C), and sodium deoxycholate (Na-DC) have been selected as surfactants to study the solubilization process of these drugs...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29218505/antibacterial-and-antibiofilm-activity-of-lactic-acid-bacteria-isolated-from-traditional-artisanal-milk-cheese-from-northeast-china-against-enteropathogenic-bacteria
#4
Xingyang Cui, Yunjia Shi, Shanshan Gu, Xin Yan, Hongyan Chen, Junwei Ge
The present study aims to investigate the probiotic properties of novel strains of lactic acid bacteria isolated from traditional artisanal milk cheese from Northeast China and to explore their antibacterial activity against enteropathogenic bacteria. Of the 321 isolates, 86 exhibited survival in low pH, resistance to pancreatin, and tolerance to bile salts; of these, 12 inhibited the growth of more than seven enteropathogenic bacteria and exhibited antibiofilm activities against Staphylococcus aureus CMCC26003 and/or Escherichia coli CVCC230...
December 7, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29218041/mrp-antiporters-have-important-roles-in-diverse-bacteria-and-archaea
#5
REVIEW
Masahiro Ito, Masato Morino, Terry A Krulwich
Mrp (Multiple resistance and pH) antiporter was identified as a gene complementing an alkaline-sensitive mutant strain of alkaliphilic Bacillus halodurans C-125 in 1990. At that time, there was no example of a multi-subunit type Na+/H+ antiporter comprising six or seven hydrophobic proteins, and it was newly designated as the monovalent cation: proton antiporter-3 (CPA3) family in the classification of transporters. The Mrp antiporter is broadly distributed among bacteria and archaea, not only in alkaliphiles...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29205766/the-bile-salt-sodium-taurocholate-induces-campylobacter-jejuni-outer-membrane-vesicle-production-and-increases-omv-associated-proteolytic-activity
#6
Abdi Elmi, Amber Dorey, Eleanor Watson, Heena Jagatia, Neil F Inglis, Ozan Gundogdu, Mona Bajaj-Elliott, Brendan W Wren, David G E Smith, Nick Dorrell
Campylobacter jejuni, the leading cause of bacterial acute gastroenteritis worldwide, secretes an arsenal of virulence-associated proteins within outer membrane vesicles (OMVs). C. jejuni OMVs contain three serine proteases (HtrA, Cj0511 and Cj1365c) which cleave the intestinal epithelial cell (IEC) tight and adherens junction proteins occludin and E-cadherin, promoting enhanced C. jejuni adhesion to and invasion of IECs. C. jejuni OMVs also induce IECs innate immune responses. The bile salt sodium taurocholate (ST) is sensed as a host signal to co-ordinate the activation of virulence-associated genes in the enteric pathogen Vibrio cholerae...
December 4, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29198808/development-of-rectal-self-emulsifying-suspension-of-a-moisture-labile-water-soluble-drug
#7
Tina Kauss, Alexandra Gaubert, Luc Tabaran, Giovanni Tonelli, Thida Phoeung, Marie-Hélène Langlois, Nick White, Anthony Cartwright, Melba Gomes, Karen Gaudin
Self-emulsifying drug delivery systems, commonly used for oral delivery of poorly soluble compounds, were used to formulate water soluble but moisture labile compounds for rectal application. The objective was to use the oily phase of the system to formulate a liquid, non-aqueous product while obtaining the advantages of self-emulsification, rapid contact with the rectal mucosa and rapid absorption post-administration. Ceftriaxone was used as a model drug and the human bile salt sodium chenodeoxycholate was used as an absorption enhancer...
November 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29196175/anti-tubercular-and-probiotic-properties-of-coagulase-negative-staphylococci-isolated-from-koozh-a-traditional-fermented-food-of-south-india
#8
Ameer Khusro, Chirom Aarti, Azger Dusthackeer, Paul Agastian
In the last few years, the demand for the tremendous therapeutic applications of indigenous probiotic bacteria from diversified fermented food products has surged. In view of this, the present study was documented to evaluate the anti-tubercular and probiotic properties of coagulase-negative staphylococci (CNS) indigenous to Koozh, a traditional fermented food product of South India. A total of 18 isolates were purified from Koozh, and tested for anti-tubercular activity against Mycobacterium tuberculosis H37Rv using luciferase reporter phage (LRP) assay...
November 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29184254/characterization-of-probiotic-potential-of-bacillus-species-isolated-from-a-traditional-brine-pickle
#9
K Ragul, Ibadondor Syiem, K Sundar, Prathapkumar H Shetty
Fermented foods are known for their potential as main source of probiotics. The present study aimed at investigating the probiotic properties of bacteria isolated from fermented mango pickle. Non-hemolytic fermenting microbiota isolated from mango pickle was screened in vitro for their basic probiotic properties such as acid tolerance, bile salt, lysozyme and salt tolerance. They were also tested for their beneficial characters like cholesterol removal, bacterial adhesion to hydrocarbons, auto-aggregation, antimicrobial activity, β-galactosidase activity, exopolysaccharide production and adhesion to HT-29 cell line...
December 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29183647/in-vitro-digestion-of-curcumin-loaded-chitosan-coated-liposomes
#10
Francesca Cuomo, Martina Cofelice, Francesco Venditti, Andrea Ceglie, Maria Miguel, Björn Lindman, Francesco Lopez
Liposomes are considered a major route for encapsulation of hydrophilic and hydrophobic molecules. Chitosan coated liposomes could represent an alternative way as a carrier for delivery of drugs in human body. In this study the preparation and applicability of chitosan-coated liposomes containing curcumin as well as curcumin loaded anionic liposomes were evaluated. The applicability of the carriers was tested by means of an in-vitro digestion procedure allowing for measurement of the bioaccessibility of ingested curcumin...
November 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29181803/functional-characterization-of-probiotic-potential-of-novel-pigmented-bacterial-strains-for-aquaculture-applications
#11
Sekar Jinendiran, Seenivasan Boopathi, Natesan Sivakumar, Gopal Selvakumar
The bioprospecting proficient of novel pigmented probiotic strains with respect to aquaculture industry was unexplored hitherto. In this study, we investigated the probiotic potential of novel pigmented bacterial strains isolated from the indigenous soil sediments in their vicinal habitats, which were screened for their antimicrobial activity against aquatic pathogens using agar well diffusion assay. The strains namely Exiguobacterium acetylicum (S01), Aeromonas veronii (V03), and Chryseobacterium joostei (V04) were phenotypically identified and confirmed by 16S rRNA gene sequence analysis...
November 27, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29181802/study-and-understanding-behavior-of-alginate-inulin-synbiotics-beads-for-protection-and-delivery-of-antimicrobial-producing-probiotics-in-colonic-simulated-conditions
#12
Abdelbasset Atia, Ahmed Gomaa, Benoit Fernandez, Muriel Subirade, Ismail Fliss
According to the World Health Organization (WHO), using antibiotics as growth promoters for livestock-particularly swine-is the principal cause of antibiotic resistance. It is therefore clear that finding an alternative to antibiotics becomes an emergency. Hundreds of recent studies have appointed probiotics as potential candidates to replace or to be used in combination with antibiotics. However, bringing probiotics alive to the colon-their site of action-remains a big challenge because of different physiological barriers encountered in proximal gastrointestinal tract (GIT) such as acidic pH and bile salts that may affect the viability of probiotic cultures...
November 27, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29179882/probiotic-potential-of-lactobacilli-with-antagonistic-activity-against-pathogenic-strains-an-in-vitro-validation-for-the-production-of-inhibitory-substances
#13
Chidre Prabhurajeshwar, Revanasiddappa Kelmani Chandrakanth
BACKGROUND: Probiotics, live cells with different beneficiary characteristics, have been extensively studied and explored commercially in many different products in the world. Their benefits to human and animal health have proven in hundreds of scientific studies. Based on rich bibliographic material, Curd is the potential source of probiotic Lactobacilli. METHOD: The aim of the present study was to observe Lactobacilli with probiotic potential activities from different curd samples for isolation, identification and characterization of Lactobacillus species...
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29177837/high-throughput-flow-cytometry-screening-of-multidrug-efflux-systems
#14
Mark K Haynes, Matthew Garcia, Ryan Peters, Anna Waller, Pietro Tedesco, Oleg Ursu, Cristian G Bologa, Radleigh G Santos, Clemencia Pinilla, Terry H Wu, Julie A Lovchik, Tudor I Oprea, Larry A Sklar, George P Tegos
The resistance nodulation cell division (RND) family of proteins are inner membrane transporters that associate with periplasmic adaptor proteins and outer membrane porins to affect substrate transport from the cytosol and periplasm in Gram-negative bacteria. Various structurally diverse compounds are substrates of RND transporters. Along with their notable role in antibiotic resistance, these transporters are essential for niche colonization, quorum sensing, and virulence as well as for the removal of fatty acids and bile salts...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29175670/apoe-is-a-major-determinant-of-hepatic-bile-acid-homeostasis-in-mice
#15
Sandra von Hardenberg, Carsten Gnewuch, Gerd Schmitz, Jürgen Borlak
Apolipoprotein E (ApoE) plays a central role in lipid transport and cholesterol metabolism, with surplus cholesterol being removed from the liver through bile acid (BA) synthesis. Furthermore, BAs are of critical importance in fat absorption by forming intestinal lipid-bile salt mixed micelles. To define ApoE's role in BA homeostasis, the metabolism of cholesterol and BA was investigated in liver tissue and gallbladder bile of ApoE-deficient mice given a chow or high-cholesterol/high-fat diet (HCHF) diet for 6 months...
September 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29174701/tadpoles-fed-supplemented-diet-with-probiotic-bacterium-isolated-from-the-intestinal-tract-of-bullfrog-lithobates-catesbeianus-haematology-cell-activity-and-electron-microscopy
#16
S A Pereira, G T Jerônimo, N C Marchiori, H M Oliveira, G F A Jesus, E C Schmidt, Z L Bouzon, F N Vieira, M L Martins, J L P Mouriño
The aim of this study is to select and isolate autochthonous bacteria with probiotic potential for use in a supplemented diet for bullfrog tadpoles, Lithobates catesbeianus. A total of 20 strains of lactic acid bacteria were isolated. Nine out of these were used in the following in vitro assays: antagonism against pathogenic bacteria (ANT), antimicrobial activity from extracellular compounds (MIC), tolerance to bile salts (TBS), pH reduction, protease production, sensitivity to antimicrobial tetracycline, cell viability, growth rate and doubling time...
November 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29167835/sensitizing-clostridium-difficile-spores-with-germinants-on-skin-and-environmental-surfaces-represents-a-new-strategy-for-reducing-spores-via-ambient-mechanisms
#17
Michelle M Nerandzic, Curtis J Donskey
Background: Clostridium difficile is a leading cause of healthcare-associated infections worldwide. Prevention of C. difficile transmission is challenging because spores are not killed by alcohol-based hand sanitizers or many commonly used disinfectants. One strategy to control spores is to induce germination, thereby rendering the spores more susceptible to benign disinfection measures and ambient stressors. Methods/Results: C. difficile spores germinated on skin after a single application of cholic acid-class bile salts and co-germinants; for 4 C...
October 30, 2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/29164617/differential-perturbation-of-the-protrotropic-equilibrium-of-a-biological-photosensitizer-within-bile-salt-aggregates-of-varying-hydrophobicity-a-fluorimetric-investigation
#18
Riya Sett, Nikhil Guchhait
The present work reveals the binding interactions of a credible cancer cell photosensitizer, harmane (HM) with some selected bile salt aggregates of dissimilar hydrophobicity viz. sodium deoxycholate (NaDC), sodium cholate (NaC) and sodium taurocholate (NaTC). The explicit variation of the prototropic equilibrium of the photosensitizer both in the ground and excited state has been utilized to scrutinize the interaction phenomena. Differential modulation in the prototropic equilibrium of HM in the aforesaid aggregates has been explained on the basis of the structural dissimilarities of the bile-salt monomers...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29159445/probiotic-properties-and-cellular-antioxidant-activity-of-lactobacillus-plantarum-ma2-isolated-from-tibetan-kefir-grains
#19
Wei Tang, Chao Li, Zengguo He, Fen Pan, Shuo Pan, Yanping Wang
Lactobacillus plantarum MA2 was isolated from traditional Chinese Tibetan kefir grains. Its antioxidant properties had been demonstrated in vitro and in vivo previously. In the present study, the probiotic characteristics of this strain were further evaluated by investigating its acid and bile salt tolerances, cell surface hydrophobicity, and autoaggregation, respectively. In addition, the cellular antioxidant activity (CAA) assay was applied to test the antioxidant capacity of the isolate in different growth phases...
November 20, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29155085/ir-spectroscopy-analysis-of-pancreatic-lipase-related-protein-2-interaction-with-phospholipids-2-discriminative-recognition-of-various-micellar-systems-and-characterization-of-plrp2-dppc-bile-salt-complexes
#20
Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Deborah Byrne, Hélène Gaussier, Frédéric Carrière
The interaction of pancreatic lipase-related protein 2 (PLRP2) with various micelles containing phospholipids was investigated using pHstat enzyme activity measurements, differential light scattering, size exclusion chromatography (SEC) and transmission IR spectroscopy. Various micelles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and lysophosphatidylcholine were prepared with either bile salts (sodium taurodeoxycholate or glycodeoxycholate) or Triton X-100, which are substrate-dispersing agents commonly used for measuring phospholipase activities...
November 16, 2017: Chemistry and Physics of Lipids
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