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Shideh Anvari, Mohammad Ali Akbarzadeh, Fariba Bayat, Mohammad Hasan Namazi, Morteza Safi
BACKGROUND: Implantable cardioverter-defibrillator (ICD) is the most effective therapy currently available to prevent sudden cardiac death (SCD) in patients with left ventricular (LV) dysfunction. Although LV ejection fraction (LVEF) is an excellent marker of SCD in these patients, but determining other predictors might help to identify patients who will be benefit more from device implantation. The purpose of this study was to determine whether abnormal LV sphericity index (SI) in transthoracic echocardiography is associated with appropriate ICD therapy in these patients...
June 21, 2018: Pacing and Clinical Electrophysiology: PACE
Yasushi Wakabayashi, Takeshi Mitsuhashi, Naoyuki Akashi, Takekuni Hayashi, Tomio Umemoto, Yoshitaka Sugawara, Hideo Fujita, Shin-Ichi Momomura
Previous studies suggested that right ventricular pacing was associated with pacing-induced cardiac dysfunction (PICD). The purpose of this study was to investigate the clinical characteristics including the incidence of undiagnosed cardiac sarcoidosis (CS) in patients with atrioventricular block (AVB) who manifest PICD. We retrospectively investigated consecutive patients with permanent pacemaker (PPM) undergoing a first-generator replacement surgery with a new PPM or an upgrade procedure to a cardiac resynchronization therapy (CRT) device between December 1, 2011 and June 30, 2017...
June 21, 2018: Heart and Vessels
Beatrice von Jeinsen, Meghan I Short, Vanessa Xanthakis, Herman Carneiro, Susan Cheng, Gary F Mitchell, Ramachandran S Vasan
BACKGROUND: Adipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity-associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community-based sample. METHODS AND RESULTS: We evaluated 3514 Framingham Heart Study participants (mean age 40 years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid-binding protein 4, retinol-binding protein 4, fetuin-A, and adiponectin...
June 21, 2018: Journal of the American Heart Association
Christian Besler, Stephan Blazek, Karl-Philipp Rommel, Thilo Noack, Maximilian von Roeder, Christian Luecke, Joerg Seeburger, Joerg Ender, Michael A Borger, Axel Linke, Matthias Gutberlet, Holger Thiele, Philipp Lurz
OBJECTIVES: The present study aimed to test the clinical benefit of combined transcatheter mitral plus tricuspid valve edge-to-edge repair (TMTVR) as compared with transcatheter mitral valve edge-to-edge repair (TMVR) alone in patients with both significant mitral (MR) and tricuspid regurgitation (TR) at high surgical risk. BACKGROUND: A growing number of patients with severe MR at increased surgical risk are treated by transcatheter techniques. Evidence suggests that residual TR remains a predictor of adverse outcome in these patients...
June 25, 2018: JACC. Cardiovascular Interventions
Norihiko Kamioka, Vasilis Babaliaros, Michael Andrew Morse, Tiberio Frisoli, Stamatios Lerakis, Jose Miguel Iturbe, Jose Binongo, Frank Corrigan, Altayyeb Yousef, Patrick Gleason, John A Wells, Hope Caughron, Andy Dong, Evelio Rodriguez, Bradley Leshnower, William O'Neill, Gaetano Paone, Marvin Eng, Robert Guyton, Peter C Block, Adam Greenbaum
OBJECTIVES: There are minimal data regarding clinical outcomes and echocardiographic findings after transcatheter mitral valve-in-valve replacement (TMVR) compared with redo surgical mitral valve replacement (SMVR). BACKGROUND: TMVR therapy has emerged as therapy for a degenerated bioprosthetic valve failure. METHODS: The authors retrospectively identified patients with degenerated mitral bioprostheses who underwent redo SMVR or TMVR at 3 U...
June 25, 2018: JACC. Cardiovascular Interventions
Brian R Weil, Gen Suzuki, Rebeccah F Young, Vijay Iyer, John M Canty
BACKGROUND: The authors previously demonstrated that brief ischemia elicits cardiac troponin I (cTnI) release and myocyte apoptosis in the absence of necrosis. It remains uncertain whether other pathophysiological stresses can produce apoptosis and transient cTnI release without ischemia. OBJECTIVES: This study sought to determine whether a transient increase in left ventricular (LV) preload elicits cTnI release in the absence of ischemia. METHODS: Propofol-anesthetized swine (N = 13) received intravenous phenylephrine (PE) (300 μg/min) for 1 h to increase left ventricular end-diastolic pressure (LVEDP) to ∼30 mm Hg...
June 26, 2018: Journal of the American College of Cardiology
Francielly Mourão Gasparotto, Francislaine Aparecida Dos Reis Lívero, Rhanany Allan Caloi Palozi, Maria Leticia Ames, Bruna Nunes, Guilherme Donadel, Rita de Cassia Lima Ribeiro, Emerson Luiz Botelho Lourenço, Cândida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior
Excess weight and dyslipidemia are among the most serious health problems in Western societies. These conditions enhance the risk of cardiac disease and have been linked with a higher prevalence of cardiac arrhythmias and sudden death. The present study investigated the cardioprotective effects of Echinodorus grandiflorus on ventricular remodeling in rabbits that were fed a 1% cholesterol-rich diet. We first obtained an ethanol-soluble fraction of E. grandiflorus and performed a detailed phytochemical study by liquid chromatography-DAD/ESI-MS...
June 21, 2018: Planta Medica
Liang Xiong, Yu Liu, Mingmin Zhou, Guangji Wang, Dajun Quan, Wei Shuai, Caijie Shen, Bin Kong, Congxin Huang, He Huang
NEW FINDINGS: What is the central question of this study? In this study, we investigated whether targeted ablation of cardiac sympathetic neurons (TACSN) could suppress myocardial infarction-induced adverse cardiac remodeling and left ventricle dysfunction. What is the main finding and its importance? TACSN significantly alleviated sympathetic remodeling and neuroendocrine activation, attenuated cardiac hypertrophy and fibrosis, and improved the left ventricular function. Thus, TACSN may have a beneficial effect on adverse post-infarction remodeling and left ventricle dysfunction...
June 21, 2018: Experimental Physiology
Sarah Ghulam Ali, Laura Fusini, Alessia Dalla Cia, Gloria Tamborini, Paola Gripari, Manuela Muratori, Maria E Mancini, Andrea Annoni, Alberto Formenti, Mauro Pepi
PURPOSE: The aim of this study was to evaluate the feasibility and accuracy of 2-dimensional (2D) and 3-dimensional (3D) transthoracic echocardiography (2DTTE, 3DTTE) versus multidetector computed tomography (MDCT) in patients with ascending aortic (AA) dilation. MATERIALS AND METHODS: Fifty consecutive patients with AA dilation were evaluated by 2DTTE, X-plane (XP) 3DTTE, and MDCT. Aorta diameters were measured at aortic annulus, aortic root (SIN), sinotubular junction, AA, aortic arch before the prebrachiocephalic artery (PRE), and before left subclavian artery (INTRA)...
July 2018: Journal of Thoracic Imaging
Steven M Bradley, Katie Foag, Khua Monteagudo, Pam Rush, Craig E Strauss, Mario Gössl, Paul Sorajja
OBJECTIVE: To determine the implications of applying guideline-recommended definitions of aortic stenosis to echocardiographic data captured in routine clinical care. METHODS: Retrospective observational study of 213 174 patients who underwent transthoracic echocardiographic imaging within Allina Health between January 2013 and October 2017. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of echocardiographic measures for severe aortic stenosis were determined relative to the documented interpretation of severe aortic stenosis...
June 20, 2018: Heart: Official Journal of the British Cardiac Society
C X Xu, L Li, S J Gong, Y H Yu, J Yan
Objective: To investigate the effect of levosimendan on cardiac function and prognosis in elderly patients with septic myocardial contractility impairment. Methods: A prospective, randomized, controlled study was conducted. The elderly patients with septic myocardial contractility impairment who were admitted to Intensive Care Unit in Zhejiang Hospital were consecutively enrolled from January 2017 to September 2017. The key inclusive criterion was left ventricular ejection fraction (LVEF) ≤50% after fluid resuscitation...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Vanesa Cristina Lozano Granero, Sara Fernández Santos, Covadonga Fernández-Golfín, María Plaza Martín, Jesús María de la Hera Galarza, Francesco Fulvio Faletra, Martin J Swaans, Teresa López-Fernández, Dolores Mesa, Giovanni La Canna, Tomás Echeverría García, Gilbert Habib, Amparo Martíne Monzonís, José Luis Zamorano Gómez
BACKGROUND: Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) has become a widespread technique for patients with severe AS considered inoperable or high risk for traditional open-surgery. This procedure could have a positive impact in LV mechanics. The aim of this study was to evaluate the immediate effect of TAVR on LV function recovery, as assessed by myocardial deformation parameters. METHODS: One-hundred twelve consecutive patients (81...
June 20, 2018: Cardiology Journal
Aleksandra Liżewska-Springer, Alicja Dąbrowska-Kugacka, Ewa Lewicka, Łukasz Drelich, Tomasz Królak, Grzegorz Raczak
BACKGROUND: Catheter ablation (CA) is a well-known treatment option for patients with symptomatic drug-resistant atrial fibrillation (AF). Multiple factors have been identified to determine AF recurrence after CA, however their predictive value is rather small. Identification of novel predictors of CA outcome is therefore of primary importance to reduce health costs and improve long-term results of this intervention. The recurrence of AF following CA is related to the severity of left ventricular (LV) dysfunction, extend of atrial dilatation and fibrosis...
June 20, 2018: Cardiology Journal
Sezen Ugan Atik, Ayşe Güler Eroğlu, Betül Çinar, Murat Tuğberk Bakar, İrfan Levent Saltik
The two main modalities used for congenital aortic valvular stenosis (AVS) treatment are balloon aortic valve dilatation (BAD) and surgical aortic valvuloplasty (SAV). This study evaluates residual and recurrent stenosis, aortic regurgitation (AR) development/progression, reintervention rates, and the risk factors associated with this end point in patients with non-critical congenital AVS who underwent BAD or SAV after up to 18 years of follow-up. From 1990 to 2017, 70 consecutive interventions were performed in patients with AVS, and 61 were included in this study (33 BADs and 28 SAVs)...
June 19, 2018: Pediatric Cardiology
Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori
Levosimendan and milrinone may be used in place of dobutamine to increase cardiac output in septic patients with a low cardiac output due to impaired cardiac function. The effects of the two inotropic agents on cardiac inflammation and left ventricular (LV) performance were examined in mice with cecal ligation and puncture (CLP)-induced sepsis. CLP mice displayed significant cardiac inflammation, as indicated by highly increased pro-inflammatory cytokines and neutrophil infiltration in myocardial tissues. When continuously given, levosimendan prevented but milrinone exaggerated cardiac inflammation, but they significantly reduced the elevations in plasma cardiac troponin-I and heart-type fatty acid-binding protein, clinical markers of cardiac injury...
June 20, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Onur Argan, Dilek Ural, Kurtuluş Karauzum, Serdar Bozyel, Mujdat Aktas, Irem Yilmaz Karauzum, Güliz Kozdag, Aysen Agacdiken Agir
Background: Elevated vitamin B12 is a sign for liver damage, but its significance in chronic stable heart failure (HF) is less known. The present study investigated the clinical correlates and prognostic significance of vitamin B12 levels in stable systolic HF. Methods: A total of 129 consecutive patients with HF and 50 control subjects were enrolled. Data regarding demographics, clinical signs, therapeutic and conventional echocardiographic measurements were recorded for all patients...
2018: Therapeutics and Clinical Risk Management
Yasser Ahmad Bhat, Himanshu Pratap, Kulbhushan Singh Dagar, Neeraj Awasthy
The clinical detail, echocardiographic features, angiographic evaluation, and surgical repair of double-outlet left atrium (LA) in a 2-year-old boy are discussed. In a solitus position and normally connected systemic and pulmonary venous drainage setting, the only outlet of the right atrium was a secundum atrial septal defect. The LA thus received the entire venous return and then drained into both ventricles through a common atrioventricular valve.
May 2018: Annals of Pediatric Cardiology
Beatriz Picazo-Angelin, Juan Ignacio Zabala-Argüelles, Robert H Anderson, Damian Sánchez-Quintana
The rapid changes that have taken place in recent years in relation to techniques used to image the fetal heart have emphasized the need to have a detailed knowledge ofnormal cardiac anatomy. Without such knowledge, it is difficult, if not impossible, to recognize the multiple facets of congenital cardiac disease. From the inception of fetal echocardiographic screening, the importance of basic knowledge of cardiac anatomy has been well recognized. The current machines used for imaging, however, now make it possible potentially to recognize features not appreciated at the start of the specialty...
May 2018: Annals of Pediatric Cardiology
Seth Uretsky, Edgar Argulian, Azhar Supariwala, Leo Marcoff, Konstantinos Koulogiannis, Lillian Aldaia, Farooq A Chaudhry, Steven D Wolff, Linda D Gillam
BACKGROUND: The American Society of Echocardiography (ASE) guidelines suggest the use of several echocardiographic methods to assess mitral regurgitation severity using an integrated approach, without guidance as to the weighting of each parameter. The purpose of this multicenter prospective study was to evaluate the recommended echocardiographic parameters against a reference modality and develop and validate a weighting for each echocardiographic measure of mitral regurgitation severity...
June 16, 2018: Journal of the American Society of Echocardiography
Robert A Sorabella, Anna Olds, Halit Yerebakan, Dua Hassan, Michael A Borger, Michael Argenziano, Craig R Smith, Isaac George
BACKGROUND: A significant proportion of patients presenting for isolated aortic valve replacement (AVR) demonstrate some degree of functional mitral regurgitation (fMR). Guidelines addressing concomitant mitral valve intervention in those patients with moderate fMR lack strong evidence-based support. Our aim is to determine the effect of untreated moderate fMR at the time of AVR on long-term survival. METHODS: All patients undergoing isolated AVR from 2000 to 2013 at our institution were retrospectively reviewed...
June 19, 2018: Journal of Cardiothoracic Surgery
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