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Women and epilepsy

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https://www.readbyqxmd.com/read/28732257/epileptiform-discharges-in-eeg-and-seizure-risk-in-adolescent-children-of-women-with-epilepsy
#1
Joseph Samuel, Manna Jose, V S Nandini, Sanjeev V Thomas
We aimed to study the epileptiform discharges (ED) and seizure risk in EEG of 12-18-year-old children of women with epilepsy (WWE). Children of WWE who were prospectively followed up in the Kerala registry of epilepsy and pregnancy (KREP), aged 12-16years (n=92; males 48, females 44) underwent clinical evaluation and a 30-min digital 18-channel EEG. The EEG showed epileptiform discharges in 13 children (5 males and 8 females). The EDs were generalized in 9 and focal in 4 (occipital 2, frontal 1, and centroparietal 1)...
July 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28715490/patterns-of-care-of-brain-tumor-related-epilepsy-a-cohort-study-done-in-italian-epilepsy-center
#2
Marta Maschio, Ettore Beghi, Marina M L Casazza, Gabriella Colicchio, Cinzia Costa, Paola Banfi, Stefano Quadri, Paolo Aloisi, Anna Teresa Giallonardo, Carla Buttinelli, Giada Pauletto, Salvatore Striano, Andrea Salmaggi, Riccardo Terenzi, Ornella Daniele, Giovanni Crichiutti, Francesco Paladin, Rosario Rossi, Giulia Prato, Federico Vigevano, Roberto De Simone, Federica Ricci, Marina Saladini, Fabrizio Monti, Susanna Casellato, Tiziano Zanoni, Diana Giannarelli, Giuliano Avanzini, Umberto Aguglia
Epilepsy is the most common comorbidity in patients with brain tumors. STUDY AIMS: To define characteristics of brain tumor-related epilepsy (BTRE) patients and identify patterns of care. Nationwide, multicenter retrospective cohort study. Medical records of BTRE patients seen from 1/1/2010 to 12/31/2011, followed for at least one month were examined. Information included age, sex, tumor type/treatments, epilepsy characteristics, antiepileptic drugs (AEDs). Time to modify first AED due to inefficacy and/or toxicity was assessed with the Kaplan-Meier method and Cox proportional hazard models were used to identify predictors of treatment outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28706165/-illness-experience-of-married-korean-women-with-epilepsy
#3
Young Min Shon, Woo Joung Joung
PURPOSE: The purpose of this study was to understand and describe the illness experience of married Korean women with epilepsy. METHODS: Data were collected during 2015~2016 through individual in-depth interviews with 12 married women with epilepsy. Verbatim transcripts were analyzed using Giorgi's phenomenological analysis to uncover the meaning of the illness experience of the participants. RESULTS: The study results showed that the illness experience of married Korean women with epilepsy was clustered into a specific description of situated structure and a general description of situated structure...
June 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28672292/association-between-pregnancy-and-perinatal-outcomes-among-women-with-epilepsy
#4
Neda Razaz, Torbjörn Tomson, Anna-Karin Wikström, Sven Cnattingius
Importance: To date, few attempts have been made to examine associations between exposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perinatal outcomes. Objectives: To investigate associations between epilepsy in pregnancy and risks of pregnancy and perinatal outcomes as well as whether use of AEDs influenced risks. Design, Setting, and Participants: A population-based cohort study was conducted on all singleton births at 22 or more completed gestational weeks in Sweden from 1997 through 2011; of these, 1 424 279 were included in the sample...
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28666184/pregnancy-outcome-in-women-with-epilepsy-in-western-china-a-prospective-hospital-based-study
#5
Shixu He, Huili Zhu, Xiangmiao Qiu, Xi Zhu, Anjiao Peng, Jianan Duan, Lei Chen
OBJECTIVE: Gaps exist in the diagnosis and treatment of women with epilepsy (WWE) between China and Euro-American countries. We aim to find out and share our experience of the multidisciplinary integrated treatment for WWE. METHODS: We prospectively registered WWE who were diagnosed by both epileptologists and obstetrician in our green way system for the past 5years (2009-2015). Registration information include years of education, epilepsy history, seizure type and frequency, pregnancy and delivery complications, delivery mode, and Apgar score of newborn...
June 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28654954/bioequivalence-between-generic-and-branded-lamotrigine-in-people-with-epilepsy-the-equigen-randomized-clinical-trial
#6
Michel Berg, Timothy E Welty, Barry E Gidal, Francisco J Diaz, Ron Krebill, Jerzy P Szaflarski, Barbara A Dworetzky, John R Pollard, Edmund J Elder, Wenlei Jiang, Xiaohui Jiang, Regina D Switzer, Michael D Privitera
Importance: Switching between generic antiepileptic drugs is a highly debated issue that affects both clinical care and overall health care costs. Objective: To evaluate the single-dose pharmacokinetic bioequivalence of 3 (1 branded and 2 generic drugs) on-market, immediate-release lamotrigine drug products. Design, Setting, and Participants: The Equivalence Among Antiepileptic Drug Generic and Brand Products in People With Epilepsy (EQUIGEN) single-dose study is a crossover, prospective, sequence-randomized, replicate pharmacokinetic study conducted at 5 US academic epilepsy centers...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28652270/neurogenic-pulmonary-oedema-a-rare-cause-of-maternal-collapse
#7
Huma Farooq, Sukrutha Veerareddy, Eli Silber
Acute pulmonary oedema is a significant cause of morbidity and mortality in pregnant and postpartum women. We present an unusual case of near-fatal acute pulmonary oedema in a pregnant woman, which was attributed to the acute onset of neurogenic pulmonary oedema secondary to epileptic seizure activity. The patient required supportive management in the intensive care setting for a short period and subsequently made complete recovery with regular neurological follow-up arranged for the management of her epilepsy...
June 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28646257/effect-of-epilepsy-in-pregnancy-on-fetal-growth-restriction-a-systematic-review-and-meta-analysis
#8
REVIEW
Daijuan Chen, Lisha Hou, Xia Duan, Hongling Peng, Bing Peng
PURPOSE: Epilepsy is one of the most common neurological diseases during pregnancy. However, the influence of epilepsy on fetal growth is not understood. Thus, this study conducted a meta-analysis to determine the influence of epilepsy during pregnancy on fetal growth restriction (FGR). METHODS: BIOSIS, Medline, Embase, and PubMed databases were searched between January 2000 and January 2016. Without imposing language or regional restrictions, referenced articles were selected...
June 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28641176/epilepsy-and-pregnancy-for-healthy-pregnancies-and-happy-outcomes-suggestions-for-service-improvements-from-the-multispecialty-uk-epilepsy-mortality-group
#9
REVIEW
J P Leach, P E Smith, J Craig, M Bagary, D Cavanagh, S Duncan, A R C Kelso, A G Marson, D McCorry, L Nashef, C Nelson-Piercy, R Northridge, K Sieradzan, S Thangaratinam, M Walker, J Winterbottom, M Reuber
Between 2009 and 2012 there were 26 epilepsy-related deaths in the UK of women who were pregnant or in the first post-partum year. The number of pregnancy-related deaths in women with epilepsy (WWE) has been increasing. Expert assessment suggests that most epilepsy-related deaths in pregnancy were preventable and attributable to poor seizure control. While prevention of seizures during pregnancy is important, a balance must be struck between seizure control and the teratogenic potential of antiepileptic drugs (AEDs)...
June 1, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28632041/automated-volumetry-of-hippocampus-is-useful-to-confirm-unilateral-mesial-temporal-sclerosis-in-patients-with-radiologically-positive-findings
#10
Guilherme Silva, Cristina Martins, Nádia Moreira da Silva, Duarte Vieira, Dias Costa, Ricardo Rego, José Fonseca, João Paulo Silva Cunha
Background and purpose We evaluated two methods to identify mesial temporal sclerosis (MTS): visual inspection by experienced epilepsy neuroradiologists based on structural magnetic resonance imaging sequences and automated hippocampal volumetry provided by a processing pipeline based on the FMRIB Software Library. Methods This retrospective study included patients from the epilepsy monitoring unit database of our institution. All patients underwent brain magnetic resonance imaging in 1.5T and 3T scanners with protocols that included thin coronal T2, T1 and fluid-attenuated inversion recovery and isometric T1 acquisitions...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28622545/diagnosing-psychogenic-nonepileptic-seizures-video-eeg-monitoring-suggestive-seizure-induction-and-diagnostic-certainty
#11
Stoyan Popkirov, Johannes Jungilligens, Wenke Grönheit, Jörg Wellmer
Psychogenic nonepileptic seizures (PNES) can remain undiagnosed for many years, leading to unnecessary medication and delayed treatment. A recent report by the International League Against Epilepsy Nonepileptic Seizures Task Force recommends a staged approach to the diagnosis of PNES (LaFrance, et al., 2013). We aimed to investigate its practical utility, and to apply the proposed classification to evaluate the role of long-term video-EEG monitoring (VEEG) and suggestive seizure induction (SSI) in PNES workup...
June 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28605689/folic-acid-use-by-women-with-epilepsy-findings-of-the-epilepsy-birth-control-registry
#12
Andrew G Herzog, Devon B MacEachern, Hannah B Mandle, Kaitlyn E Cahill, Kristen M Fowler, Anne R Davis, W Allen Hauser
PURPOSE: To determine the prevalence and predictors of folic acid (FA) use by women with epilepsy (WWE) at risk of unintended pregnancy. METHODS: These retrospective data come from the Epilepsy Birth Control Registry (EBCR) web-based survey of 1144 WWE in the community, 18-47years, who provided demographic, epilepsy, AED, contraception, pregnancy, healthcare visits and FA data. We report prevalence and predictors of FA use in relation to risk of pregnancy (not at risk, at risk, seeking pregnancy, pregnant), demographics, seizure types and AED and contraception categories...
June 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28605628/topiramate-associated-sexual-dysfunction-a-systematic-review
#13
REVIEW
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Kuo-Yen Chen, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin
INTRODUCTION: Sexual pharmacotoxicity renders patients with epilepsy at a risk for sexual dysfunction (SD). This study is aimed to analyze the relationship between sexual function and topiramate to avoid topiramate-associated SD. METHODS: A systematic review following the PRISMA guidelines was performed to elucidate any SD occurrence in patients receiving topiramate. RESULTS: A total of 17 publications were reviewed. Based on limited polytherapy observational studies, the frequency of self-reported topiramate-associated SD, libido disorder, and orgasmic disorder in patients with polytherapy was 9...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28592455/the-incidence-of-sudep-a-nationwide-population-based-cohort-study
#14
Olafur Sveinsson, Tomas Andersson, Sofia Carlsson, Torbjörn Tomson
OBJECTIVE: To identify all cases of sudden unexpected death in epilepsy (SUDEP) among people in Sweden during 1 year and to determine the SUDEP incidence in relation to age, sex, and psychiatric comorbidity. METHODS: We included all individuals with a hospital-based ambulatory care or hospital discharge diagnosis of epilepsy in the Swedish National Patient Registry during 1998-2005 who were alive on January 1, 2008. Deaths during 2008 were identified by linkage to the National Cause of Death Registry...
July 11, 2017: Neurology
https://www.readbyqxmd.com/read/28591672/global-variation-in-pregnancy-complications-in-women-with-epilepsy-a-meta-analysis
#15
John Allotey, David Aroyo-Manzano, Patricia Lopez, Luz Viale, Javier Zamora, Shakila Thangaratinam
OBJECTIVE: Women with epilepsy are at risk of pregnancy complications. Whether these vary globally is unknown. We undertook a systematic review to assess the overall rates of obstetric outcomes in women with epilepsy, and variations in estimates across geographical region, economic status of country, and over time. STUDY DESIGN: We searched Medline, Embase, Cochrane, AMED and CINAHL, (January 1, 1990 and November 29, 2016), without any language restrictions for studies reporting core maternal and fetal outcomes in women with epilepsy...
May 30, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28590833/evaluation-of-a-decision-aid-for-women-with-epilepsy-who-are-considering-pregnancy-a-randomized-controlled-trial
#16
Amanda McGrath, Louise Sharpe, Suncica Lah, Kaitlyn Parratt
BACKGROUND: For many women with epilepsy (WWE), decision making about pregnancy is complicated by considerations such as the potential teratogenicity of antiepileptic drugs, offspring risk of epilepsy, seizure occurrence during pregnancy, and the challenges of parenting amidst poorly controlled seizures. OBJECTIVE: This proof-of-concept, randomized controlled trial aimed to evaluate a decision aid (DA) developed to help WWE decide if they should start or enlarge their families...
July 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28580576/managing-epilepsy-in-women-of-childbearing-age-polish-society-of-epileptology-and-polish-gynecological-society-guidelines
#17
Joanna Jędrzejczak, Dorota Bomba-Opoń, Grzegorz Jakiel, Anna Kwaśniewska, Dagmara Mirowska-Guzel
No abstract text is available yet for this article.
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28577443/re-working-biographies-women-s-narratives-of-pregnancy-whilst-living-with-epilepsy
#18
Annalise Weckesser, Elaine Denny
This paper explores the multiple ways experiences of pregnancy and early motherhood come to 'rework' the biographies of women living with epilepsy. Pregnancy is explored as a temporarily concurrent status alongside the long-term condition of epilepsy. Narrative interviews were conducted with 32 women from across the UK. Analysis of these narratives suggests that biographical disruption and continuity are both useful in the conceptualisation of women's diverse experiences of pregnancy and epilepsy. Such findings challenge the notion that the presence of a condition over a long period of time leads to the normalisation of illness...
May 18, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28560798/vns-and-pregnancy-a-multicentric-experience-of-four-cases
#19
X Rodríguez-Osorio, F J López-González, Í Garamendi, J Rumià, A Matute, Á Prieto-González, M Carreño
BACKGROUND: Vagus nerve stimulation system (VNS) has been employed worldwide as adjunctive therapy in drug-resistant epileptic patients. Only nine previous pregnancies with six-positive outcomes have been reported in women with epilepsy treated with VNS since 1998. AIMS OF THE STUDY: To communicate the experience of pregnancies in women treated with VNS in our country. METHODS: Clinical data of four female patients treated with VNS during pregnancy and delivery in five gestations is described...
May 31, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28552155/pharmacotherapy-for-cavernous-malformations
#20
Robert F Rudy, Rose Du
Cerebral cavernous malformations, vascular abnormalities comprised of endothelial cells in the absence of connective tissue or muscle, are often epileptogenic and often treated initially with antiepileptic drugs. This chapter discusses the role of pharmacotherapy in managing focal epilepsy secondary to cavernous malformations in adults, children, and pregnant women. Several drugs are available and potentially efficacious in suppressing seizures stemming from cavernous malformations. In addition, antiepileptic pharmacotherapy following surgical resection is indicated to decrease the risk of postoperative seizures...
2017: Handbook of Clinical Neurology
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