keyword
https://read.qxmd.com/read/38532450/lymphangioleiomyomatosis-in-patients-with-tuberous-sclerosis-a-national-centre-audit
#1
JOURNAL ARTICLE
Jan Johnson, Wendy Somerfield, Simon R Johnson
BACKGROUND: Lymphangioleiomyomatosis (LAM) is common in tuberous sclerosis complex (TSC) yet under recognised with management mostly based upon evidence obtained from patients with sporadic LAM. We performed a prospective audit of patients with TSC-LAM attending a national referral centre to inform management guidelines. METHODS: The UK LAM Centre was established in 2011 and conducts a prospective audit of pre-defined quality outcomes for all subjects. Audit data are reported on all patients with TSC-LAM and a comparator population of patients with sporadic LAM...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38531811/changes-in-perampanel-pharmacokinetics-and-cytochrome-p450-3a4-activity-before-during-and-after-pregnancy
#2
JOURNAL ARTICLE
Yoshiaki Yamamoto, Naoto Akita, Hiroki Nogimoto, Wakana Suzuki, Katsumi Imai, Yukitoshi Takahashi, Yoshiyuki Kagawa
This study evaluated perampanel pharmacokinetics and cytochrome P450 3A4 (CYP3A4) activity, assessed using the level of 4β-hydroxycholesterol (4β-OHC) as an endogenous biomarker of CYP3A4, before, during, and after pregnancy in a woman with epilepsy and compared these measurements with those from a control group of nonpregnant women with epilepsy. A 21-year-old pregnant woman was being treated with perampanel (serum concentration: 1120 ng/mL), lacosamide, and lamotrigine. After the first trimester, the lamotrigine concentration decreased markedly; however, the perampanel concentration remained almost unchanged (range, 1130-1320 ng/mL)...
March 26, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38531396/practices-in-the-prescription-of-antiseizure-medications-is-it-time-to-change
#3
JOURNAL ARTICLE
Lécio Figueira Pinto, Lucas Scárdua Silva, Rafael Batista João, Vinícius Boldrini, Fernando Cendes, Clarissa Lin Yasuda
The treatment of epilepsy has advanced over the past 30 years through the development of new antiseizure medications (ASMs). Unfortunately, not all of them have been approved yet in Brazil, and many are still underused. When comparing new ASMs to older ones, they are generally not more effective in treating epilepsy. However, they offer better tolerability, with fewer interactions and long-term side effects, especially for patients with comorbidities or those requiring polytherapy. Enzyme induction caused by older ASMs is associated with increased cholesterol levels, drug interactions with decreased effects of statins and other cardiovascular medications, anticoagulants, chemotherapy, immunosuppressors, anti-infective agents (including HIV treatment), antidepressants, and contraceptives...
June 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38527794/folic-acid-in-women-with-epilepsy-prescribing-advice
#4
EDITORIAL
Michael Owen Kinney, John J Craig, Norman Delanty
No abstract text is available yet for this article.
March 25, 2024: Practical Neurology
https://read.qxmd.com/read/38527232/predictive-model-for-estimating-the-risk-of-epilepsy-after-aneurysmal-subarachnoid-hemorrhage-the-rise-score
#5
JOURNAL ARTICLE
Daniel Campos-Fernandez, Marc Rodrigo-Gisbert, Laura Abraira, Manuel Quintana Luque, Manel Santafé, Sofia Lallana, Elena Fonseca, Manuel Toledo, Darío F Gándara, Fuat Arikan, Alejandro Tomasello, Jacint X Sala Padró, Merce Falip, Pablo López-Ojeda, Andreu Gabarrós, Anna Sánchez, Estevo Santamarina
BACKGROUND AND OBJECTIVES: The occurrence of seizures after aneurysmal subarachnoid hemorrhage (aSAH) is associated with a poorer functional and cognitive prognosis and less favorable quality of life. It would be of value to promptly identify patients at risk of epilepsy to optimize follow-up protocols and design preventive strategies. Our aim was to develop a predictive score to help stratify epilepsy risk in patients with aSAH. METHODS: This is a retrospective, longitudinal study of all adults with aSAH admitted to our center (2012-2021)...
April 23, 2024: Neurology
https://read.qxmd.com/read/38526760/obesity-and-obesity-related-thyroid-dysfunction-any-potential-role-for-the-very-low-calorie-ketogenic-diet-vlckd
#6
REVIEW
Sebastián Pablo Chapela, Alison Simancas-Racines, Florencia Ceriani, Andrés Luciano Nicolas Martinuzzi, María Paula Russo, Ana Karina Zambrano, Daniel Simancas-Racines, Ludovica Verde, Giovanna Muscogiuri, Christos S Katsanos, Evelyn Frias-Toral, Luigi Barrea
PURPOSE OF REVIEW: This review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction. RECENT FINDINGS: The VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions...
March 25, 2024: Current Nutrition Reports
https://read.qxmd.com/read/38512019/sex-differences-in-the-susceptibility-to-valproic-acid-associated-liver-injury-in-epileptic-patients
#7
JOURNAL ARTICLE
Linfeng Ma, Dan Wang
BACKGROUND: Valproic acid has been widely used as an antiepileptic drug for several decades. Long-term valproic acid treatment is usually accompanied by liver injury. Although both men and women are susceptible to valproic acid-associated liver injury, hepatotoxicity differs between the sexes. However, the mechanisms underlying sex differences in valproic acid-associated liver injury remain unclear. METHODS: To explore potential risk factors for the susceptibility to valproic acid-associated liver injury, 231 pediatric patients with epilepsy (119 males, 112 females) were enrolled for laboratory and genetic analysis...
February 2024: Clinical Toxicology
https://read.qxmd.com/read/38507750/risk-of-autism-after-prenatal-topiramate-valproate-or-lamotrigine-exposure
#8
JOURNAL ARTICLE
Sonia Hernández-Díaz, Loreen Straub, Brian T Bateman, Yanmin Zhu, Helen Mogun, Katherine L Wisner, Kathryn J Gray, Barry Lester, Christopher J McDougle, Elyse DiCesare, Page B Pennell, Krista F Huybrechts
BACKGROUND: Maternal use of valproate during pregnancy has been associated with an increased risk of neurodevelopmental disorders in children. Although most studies of other antiseizure medications have not shown increased risks of these disorders, there are limited and conflicting data regarding the risk of autism spectrum disorder associated with maternal topiramate use. METHODS: We identified a population-based cohort of pregnant women and their children within two health care utilization databases in the United States, with data from 2000 through 2020...
March 21, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38507279/brain-network-entropy-depression-and-quality-of-life-in-people-with-traumatic-brain-injury-and-seizure-disorders
#9
JOURNAL ARTICLE
Jane B Allendorfer, Rodolphe Nenert, Adam M Goodman, Pranav Kakulamarri, Stephen Correia, Noah S Philip, W Curt LaFrance, Jerzy P Szaflarski
OBJECTIVE: Traumatic brain injury (TBI) often precedes the onset of epileptic (ES) or psychogenic nonepileptic seizures (PNES) with depression being a common comorbidity. The relationship between depression severity and quality of life (QOL) may be related to resting-state network complexity. We investigated these relationships in adults with TBI-only, TBI + ES, or TBI + PNES using Sample Entropy (SampEn), a measure of physiologic signals complexity. METHODS: Adults with TBI-only (n = 60), TBI + ES (n = 21), or TBI + PNES (n = 56) completed the Beck Depression Inventory-II (BDI-II; depression symptom severity) and QOL in Epilepsy (QOLIE-31) assessments and underwent resting-state functional magnetic resonance imaging (rs-fMRI)...
March 20, 2024: Epilepsia Open
https://read.qxmd.com/read/38497990/risk-of-major-congenital-malformations-and-exposure-to-antiseizure-medication-monotherapy
#10
JOURNAL ARTICLE
Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John Craig, Emilio Perucca, Anne Sabers, Sanjeev Thomas, Silje Alvestad, Piero Perucca, Frank Vajda
IMPORTANCE: Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. OBJECTIVE: To investigate the prevalence of MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes in MCM prevalence over time. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational, longitudinal cohort study conducted from June 1999 to October 2022...
March 18, 2024: JAMA Neurology
https://read.qxmd.com/read/38484631/comparison-of-neurodevelopmental-educational-and-adult-socioeconomic-outcomes-in-offspring-of-women-with-and-without-epilepsy-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Paolo Pierino Mazzone, Kirsty Mhairi Hogg, Christopher J Weir, Jacqueline Stephen, Sohinee Bhattacharya, Simone Richer, Richard F M Chin
BACKGROUND: Adequate pre-pregnancy counselling and education planning are essential to improve outcomes for offspring of women with epilepsy (OWWE). The current systematic review and meta-analysis aimed to compare outcomes for OWWE and offspring of women without epilepsy (OWWoE). METHODS: We conducted a systematic review and meta-analysis. We searched MEDLINE, EMBASE, CINAHL, PsycINFO (database inception-1st January 2023), OpenGrey, GoogleScholar, and hand-searched journals and reference lists of included studies to identify eligible studies...
February 29, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38478792/association-of-age-related-neuropathologic-findings-at-autopsy-with-a-claims-based-epilepsy-diagnosis-in-older-adults
#12
JOURNAL ARTICLE
Shahram Oveisgharan, Francine Grodstein, Arnold M Evia, Bryan D James, Ana W Capuano, Yi Chen, Konstantinos Arfanakis, Julie A Schneider, David A Bennett
BACKGROUND AND OBJECTIVES: Epilepsy is 1 of the 3 most common neurologic diseases of older adults, but few studies have examined its underlying pathologies in older age. We examined the associations of age-related brain pathologies with epilepsy in older persons. METHODS: Clinical and pathologic data came from 2 ongoing clinical pathologic cohort studies of community-dwelling older adults. Epilepsy was ascertained using Medicare fee-for-service Parts A and B claims data that were linked to data from the cohort studies...
April 9, 2024: Neurology
https://read.qxmd.com/read/38476755/prenatal-exposure-to-antiseizure-medications-and-fetal-growth-a-population-based-cohort-study-from-the-nordic-countries
#13
JOURNAL ARTICLE
Jakob Christensen, Helga Zoega, Maarit K Leinonen, Nils Erik Gilhus, Mika Gissler, Jannicke Igland, Yuelian Sun, Torbjörn Tomson, Silje Alvestad, Marte-Helene Bjørk, Julie Werenberg Dreier
BACKGROUND: The short- and long-term consequences of restricted fetal growth cause considerable concern, and how prenatal exposure to different antiseizure medications (ASMs) affects fetal growth remains uncertain. METHODS: This was a population-based cohort study of liveborn singleton children born in Denmark, Finland, Iceland, Norway, and Sweden from 1996 to 2017. Prenatal exposure was defined as maternal filling of prescriptions for ASM during pregnancy registered in national prescription registries and primary outcomes were adjusted odds ratios (aORs) of microcephaly or being born small for gestational age...
March 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38467356/characterization-of-the-intrahippocampal-kainic-acid-model-in-female-mice-with-a-special-focus-on-seizure-suppression-by-antiseizure-medications
#14
JOURNAL ARTICLE
Melanie Widmann, Andreas Lieb, Barbara Fogli, Angela Steck, Anna Mutti, Christoph Schwarzer
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures in males...
March 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38465809/-the-relationship-between-immunological-and-psychopathological-characteristics-in-patients-with-focal-epilepsy-depending-on-the-profile-of-interhemispheric-asymmetry
#15
JOURNAL ARTICLE
V V Kalinin, A A Zemlyanaya, K Y Subbotin
OBJECTIVE: To identify the possible influence of cellular immunity parameters and neurobiological variables (frequency of seizures of various semiotics and their severity) on comorbid psychopathological symptoms depending on the profile of interhemispheric asymmetry in patients with focal forms of epilepsy. MATERIAL AND METHODS: The study included 92 patients with epilepsy (38 men, 54 women, mean age 38.7+8.45 years). Focal temporal lobe epilepsy was diagnosed in 36 patients, focal frontal lobe epilepsy in 16 patients, and temporal-frontal lobe epilepsy in 40 patients...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38456606/transient-postictal-dysphagia-in-older-adults-with-focal-structural-epilepsy
#16
JOURNAL ARTICLE
Sriramya Lapa, Anna Schwingshackl, Ulrike Frank, Felix Rosenow, Catrin Mann, Adam Strzelczyk
OBJECTIVE: Seizures can cause transient neurological symptoms, such as hemiparesis and aphasia. However, temporary swallowing changes leading to postictal dysphagia have not been previously described. Therefore, this study evaluated the presence of swallowing disorders following seizure. In addition, dysphagia severity and duration of any recovery from dysphagic symptoms were investigated. METHODS: The local clinical database of all fiberoptic endoscopic evaluation of swallowing (FEES) examinations performed from 2008 to 2019 was screened for patients diagnosed with seizures, but excluding patients with intensive care unit admission or intubation >24 h...
March 8, 2024: Epilepsia
https://read.qxmd.com/read/38451327/-epilepsy-and-pregnancy
#17
REVIEW
Verena Gaus, Maria Ilyas-Feldmann, Bettina Schmitz
BACKGROUND: Regarding treatment of women of childbearing potential with epilepsy, several aspects of family planning and desire to have children have to be taken into account. OBJECTIVE: Overview of current data on mutual implications of epileptic seizures, antiseizure medication (ASM), pregnancy and child development. METHOD: Review of the current literature, discussion and presentation of resulting treatment recommendations. RESULTS: Many ASMs bear the potential for clinically relevant interactions with both contraceptives and altered concentrations of sexual hormones and modified pharmacokinetics during pregnancy...
March 7, 2024: Der Nervenarzt
https://read.qxmd.com/read/38444931/the-prevalence-of-depression-in-patients-with-epilepsy-in-the-kingdom-of-saudi-arabia
#18
JOURNAL ARTICLE
Saleh K Swailem, Fawziah A Bamogaddam, Alawi A Al-Attas
Objective Among patients with epilepsy (PWE), the prevalence of depression ranges from 30% to 50%, with a 5-25% prevalence of suicide. Depression and epilepsy affect daily tasks such as driving, employment, and physical activity. Depression is the most common comorbidity among patients with epilepsy. Because both conditions involve pathophysiological changes, treating mood disorders helps treat epilepsy and vice versa. Studies about epilepsy and depression in Saudi Arabia are scarce, and no study has been conducted on this topic at King Fahad Medical City (KFMC); hence, we aimed to determine the prevalence of depression among PWE who were followed up at KFMC...
March 2024: Curēus
https://read.qxmd.com/read/38442517/pregnancy-antiseizure-medications-and-unexplained-intrauterine-foetal-death
#19
JOURNAL ARTICLE
Frank J E Vajda, Terence J O'Brien, Janet E Graham, Alison E Hitchcock, Piero Perucca, Cecilie M Lander, Mervyn J Eadie
OBJECTIVE: To assess the role of antiseizure medication (ASM) regimens and other factors in relation to the occurrence of intrauterine foetal death (IUFD) in pregnant women with epilepsy (WWE) enrolled in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs (APR). RESULTS: IUFDs occurred in 70 (3.01 %) of 2,323 prospective pregnancies from WWE with known outcomes in the APR. Factors associated with IUFD occurrence included older maternal age, enrolment in the APR at an earlier stage of pregnancy, history of pregnancies which did not result in livebirths, parental history of foetal malformations, and maternal use of carbamazepine, lamotrigine or ethosuximide...
March 4, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38436389/nonconvulsive-status-epilepticus-clinical-findings-eeg-features-and-prognosis-in-a-developing-country-mexico
#20
JOURNAL ARTICLE
Daniel San-Juan, Erick B Ángeles, María Del Carmen F González-Aragón, Jacob Eli G Torres, Ángel L Lorenzana, Carlos Trenado, David J Anschel
PURPOSE: There is a lack of clinical and epidemiological knowledge about nonconvulsive status epilepticus (NCSE) in developing countries including Mexico, which has the highest prevalence of epilepsy in the Americas. Our aim was to describe the clinical findings, EEG features, and outcomes of NCSE in a tertiary center in Mexico. METHODS: We conducted a retrospective case series study (2010-2020) including patients (≥15 years old) with NCSE according to the modified Salzburg NCSE criteria 2015 with at least 6 months of follow-up...
March 1, 2024: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
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