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Ashwinikumar Patil, Datta More, Anant Patil, Kishor A Jadhav, Myriam E Vijil Mejia, Suresh S Patil
OBJECTIVE: To examine the clinical pattern of foot-related complications in type 2 diabetes patients. MATERIAL AND METHODS: A cross-sectional study was conducted among indoor, adult type 2 diabetes patients with risk factors for diabetic foot complications. The diabetic neuropathy symptom score (DNSS), Doppler scanning, ankle brachial pressure index (ABPI) assessment, neuropathy assessment, neuropathic disability score (NDS), biothesiometry evaluation, and bacteriological examination was performed...
April 18, 2018: Curēus
Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Lyu
Post-incision pain often occurs after surgery and is emergent to be treated in clinic. It hinders the rehabilitation of patients and easily leads to various types of postoperative complications. Acupuncture-combined anesthesia (ACA) is the combination of traditional acupuncture and modern anesthesia, which means acupuncture is applied at acupoints with general anesthesia. It was testified that ACA strengthened the analgesic effect and reduced the occurrence of postoperative pain, but its mechanism was not clear...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Ricardo D Bennun, Eduardo Stefano, Luis E Moggi
: Van der Woude syndrome is the most generic form of syndromic orofacial cleft, present in approximately 2% of all cleft patients. The lower lip pits with or without cleft lip and/or palate is typical of this syndrome. Popliteal pterygium syndrome (PPS), also known as popliteal web syndrome or fasciogenito-popliteal syndrome, was first described by Trelat in 1869, the incidence is approximately 1 in 300,000 live births. The term PPS was coined by Gorlin et al in 1968 based on the most unusual anomaly, the popliteal pterygium...
June 18, 2018: Journal of Craniofacial Surgery
Kuwabo Mubyana, David Thomas Corr
The treatment of injured tendon is an ever-increasing clinical and financial burden, for which tissue-engineered replacements have shown great promise. Recently, there has been growing interest in a more regenerative approach to tissue engineering, in which the cells' ability to self-assemble and create matrix is harnessed to create tissue constructs without the use of a scaffold. Herein, utilizing our scaffold-free technique to engineer tendon at the single fiber level, we study how applied mechanical loading, namely cyclic uniaxial strain, influences the mechanical properties and nuclear alignment of developing tendon fiber constructs...
June 19, 2018: Tissue Engineering. Part A
Jesse M Charlton, Gillian L Hatfield, Jordan A Guenette, Michael A Hunt
Toe-in and toe-out gait modification has received attention lately as a promising treatment for knee osteoarthritis due to its potential to improve knee joint loading and pain. However, the neuromuscular patterns associated with these walking styles are not well known, a factor that may influence knee joint load itself. Our aim was to conduct a thorough examination of the neuromuscular patterns associated with toe-in and toe-out walking in people with knee osteoarthritis. Fifteen participants were instructed to walk in four different foot rotations: 10° toe-in, 0°, as well as 10° and 20° toe-out...
June 15, 2018: Journal of Biomechanics
Abdullah Al Wahbi
Diabetes is associated with various complications and reduced quality of life. Of the many complications, some are life-threatening. Among these, foot complications remain an important concern. The major foot complications include foot ulceration, cellulitis, abscess, wet gangrene, dry gangrene, and necrotizing fasciitis, with different pathophysiological concepts behind each of them. Gangrene occurs due to reduced blood supply in the body tissues that leads to necrosis. This condition may arise because of an injury, infection, or other health conditions, majorly diabetes...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
David Coman, Lisenka E L M Vissers, Lisa G Riley, Michael P Kwint, Roxanna Hauck, Janet Koster, Sinje Geuer, Sarah Hopkins, Barbra Hallinan, Larry Sweetman, Udo F H Engelke, T Andrew Burrow, John Cardinal, James McGill, Anita Inwood, Christine Gurnsey, Hans R Waterham, John Christodoulou, Ron A Wevers, James Pitt
Mendelian disorders of cholesterol biosynthesis typically result in multi-system clinical phenotypes, underlining the importance of cholesterol in embryogenesis and development. FDFT1 encodes for an evolutionarily conserved enzyme, squalene synthase (SS, farnesyl-pyrophosphate farnesyl-transferase 1), which catalyzes the first committed step in cholesterol biosynthesis. We report three individuals with profound developmental delay, brain abnormalities, 2-3 syndactyly of the toes, and facial dysmorphisms, resembling Smith-Lemli-Opitz syndrome, the most common cholesterol biogenesis defect...
June 1, 2018: American Journal of Human Genetics
Kenneth Smith, Norman Waldrop
BACKGROUND: Turf toe is a term used to describe a hyperextension injury to the first metatarsophalangeal joint. Although the vast majority of turf toe injuries can be treated successfully without operative intervention, there are instances where surgery is required to allow the athlete to return to play. Although there is a plethora of literature on turf toe injuries and nonoperative management, there are currently few reports on operative outcomes in athletes. METHODS: We obtained all cases of turf toe repair according to the ICD-10 procedural code...
June 1, 2018: Foot & Ankle International
Latha Ramakrishnan, Sofia L Pedersen, Quezia K Toe, Gregory J Quinlan, Stephen J Wort
The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with disease...
2018: Frontiers in Physiology
Katsuhiro Masago, Kei Irie, Shiro Fujita, Fumiko Imamichi, Yutaka Okada, Nobuyuki Katakami, Shoji Fukushima, Yasushi Yatabe
PURPOSE: The purpose of the study was to evaluate the site of paronychia in patients with non-small cell lung cancer harboring an epidermal growth factor receptor (EGFR) gene activating mutation who were treated with EGFR tyrosine kinase inhibitors (EGFR TKIs). PATIENTS AND METHODS: The study included 55 patients with non-small-cell lung cancer who were treated with an EGFR TKIs. Resulting all toxicities were graded using the Common Terminology Criteria for Adverse Events version 4...
June 14, 2018: Oncology
Elifcan Taşdelen, Ceren D Durmaz, Halil G Karabulut
Oculodentodigital dysplasia (ODDD) is a rare condition characterized by a typical facial appearance and variable findings of the eyes, teeth, and fingers. ODDD is caused by mutations in the GJA1 gene in chromosome 6q22 and inherited in an autosomal dominant manner in the majority of the patients. However, in recent clinical reports, autosomal recessive ODDD cases due to by GJA1 mutations were also described. Here, we report on a 14-year-old boy with microphthalmia, microcornea, narrow nasal bridge, hypoplastic alae nasi, prominent columnella, hypodontia, dental caries, and partial syndactyly of the 2nd and 3rd toes...
June 15, 2018: Cytogenetic and Genome Research
Gregory J Jenkins, Chady H Hakim, N Nora Yang, Gang Yao, Dongsheng Duan
BACKGROUND AND OBJECTIVE: Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) have become common for human gait analysis. Canines are important large animal models for translational research of human diseases. Our objective is to develop a method for accurate and reliable determination of the timing of each stride in dogs using a wearable IMU. METHODS: We built a wireless IMU sensor using off-the-shelf components...
2018: PloS One
Horea Gozar, Zoltan Derzsi, Alexandru Chira, Örs Nagy, Theodora Benedek
RATIONALE: In clubfoot deformity, planning of corrective treatment requires a complex understanding of the foot anatomy, as well as of the geometry and distribution of altered mechanical forces acting at the level of the deformed foot. At the same time, treatment success depends largely on the selection of the most appropriate shape and angles of the customized orthesis developed for foot correction. Therefore, a complex assessment of the intensity and distribution of the mechanical forces at this site is mandatory prior to initiation of any corrective therapy...
June 2018: Medicine (Baltimore)
Peter C Fino, Martina Mancini, Carolin Curtze, John G Nutt, Fay B Horak
Dual-task (DT) paradigms have been used in gait research to assess the automaticity of locomotion, particularly in people with Parkinson's disease (PD). In people with PD, reliance on cortical control during walking leads to greater interference between cognitive and locomotor tasks. Yet, recent studies have suggested that even healthy gait requires cognitive control, and that these cognitive contributions occur at specific phases of the gait cycle. Here, we examined whether changes in gait stability, elicited by simultaneous cognitive DTs, were specific to certain phases of the gait cycle in people with PD...
2018: Frontiers in Neurology
Wael Alqarawi, David H Birnie, Stewart Spence, F Daniel Ramirez, Calum J Redpath, Robert Lemery, Girish M Nair, Pablo B Nery, Darryl R Davis, Martin S Green, Luc Beauchesne, Kwan Chan, Kathryn Ascah, Ian Burwash, Mouhannad M Sadek
Aims: There is ongoing controversy about the need for routine transoesophageal echocardiography (TOE) prior to atrial fibrillation (AF) ablation. Recently, the debate was reignited by the publication of a large series of patients showing a prevalence of left atrial appendage thrombus (LAAT) on TOE of 4.4%. We sought to assess the prevalence of LAAT on TOE before AF ablation at our institution. Methods and results: Consecutive patients scheduled for AF ablation at our institution between January 2009 and December 2016 were included...
June 11, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
David A Boyce, Chantal Prewitt
CASE DESCRIPTION: A 17-year-old male post anterior cruciate ligament reconstruction complained of the inability to extend his great toe immediately following surgery. BACKGROUND: Neurological injuries following knee arthroscopy have been reported to occur between 0.6%-2.5%. The most commonly injured nerves are the saphenous and common fibular nerve (CFN). Great toe-drop secondary to isolated denervation of the extensor hallucis longus (EHL), has only been reported one time in the literature...
June 13, 2018: Physiotherapy Theory and Practice
Athina Chasapi, Adam Hobbs, Theodore Velissaris, Benoy N Shah
A 77 year old male underwent elective bioprosthetic aortic valve replacement (23mm Carpentier-Edwards Perimount MagnaEase) for severe aortic stenosis. His pre-discharge transthoracic echocardiogram (TTE) was normal. He presented 9 days after surgery with dyspnoea and fever. He was in sinus rhythm. Blood cultures were taken and he was commenced on empirical antibiotics for possible infective endocarditis (subsequently all negative). Repeat TTE showed a well-seated prosthesis without regurgitation but elevated gradients (peak / mean gradients 49 / 22 mmHg respectively)...
June 12, 2018: Echo Research and Practice
Richard A Brindle, Clare E Milner
Insufficient hip neuromuscular control may contribute to non-contact sport injuries. However, the current evaluative test of hip neuromuscular control, the single-leg squat, requires hip abductor muscle strength to complete. The purpose of this study was to develop the hip control test (HCT) and determine the test's reliability and construct validity. Nineteen healthy adults visited the laboratory twice. The HCT is a 10-s test of reciprocal toe-tapping accuracy. Both automated and manual HCT ratings were recorded simultaneously during each visit...
June 13, 2018: Sports Biomechanics
Weishuai Lian, Xiaoxiao Hu, Long Pan, Shilong Han, Chuanwu Cao, Zhongzhi Jia, Maoquan Li
BACKGROUND: The goal of this study was to characterize the properties of human CD34+ cells in culture and investigate the feasibility and efficacy of CD34+ transplantation in a mouse model of limb ischemia and in patients with no-option critical limb ischemia. METHODS: Human CD34+ cells isolated from peripheral blood and grown in culture for up to four passages stained positively for the surface markers CD34 and CD133 and showed high viability after cryopreservation and recovery...
June 11, 2018: Journal of Clinical Laboratory Analysis
L Hibrand Saint-Oyant, T Ruttink, L Hamama, I Kirov, D Lakhwani, N N Zhou, P M Bourke, N Daccord, L Leus, D Schulz, H Van de Geest, T Hesselink, K Van Laere, K Debray, S Balzergue, T Thouroude, A Chastellier, J Jeauffre, L Voisine, S Gaillard, T J A Borm, P Arens, R E Voorrips, C Maliepaard, E Neu, M Linde, M C Le Paslier, A Bérard, R Bounon, J Clotault, N Choisne, H Quesneville, K Kawamura, S Aubourg, S Sakr, M J M Smulders, E Schijlen, E Bucher, T Debener, J De Riek, F Foucher
Rose is the world's most important ornamental plant, with economic, cultural and symbolic value. Roses are cultivated worldwide and sold as garden roses, cut flowers and potted plants. Roses are outbred and can have various ploidy levels. Our objectives were to develop a high-quality reference genome sequence for the genus Rosa by sequencing a doubled haploid, combining long and short reads, and anchoring to a high-density genetic map, and to study the genome structure and genetic basis of major ornamental traits...
June 11, 2018: Nature Plants
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