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https://www.readbyqxmd.com/read/29928533/the-high-risk-groups-according-to-the-trends-and-characteristics-of-fatal-occupational-injuries-in-korean-workers-aged-50-years-and-above
#1
Kwan Hyung Yi
Background: Due to an increasing number of workers aged 50 years and above, the number of those employed is also on the rise, and those workers aged 50 and over has exceeded 50% of the total fatal occupational injuries. Therefore, it is necessary to implement the selection and concentration by identifying the characteristics of high-risk groups necessary for an effective prevention against and reduction of fatal occupational injuries. Methods: This study analyzed the characteristics of high-risk groups and the occupational injury fatality rate per 10,000 workers among the workers aged 50 and over through a multi-dimensional analysis by sex, employment status of workers, industry and occupation by targeting 4,079 persons who died in fatal occupational injuries from January 2007 to December 12...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928526/development-and-validation-of-a-practical-instrument-for-injury-prevention-the-occupational-safety-and-health-monitoring-and-assessment-tool-osh-mat
#2
Yi Sun, Martin Arning, Frank Bochmann, Jutta Börger, Thomas Heitmann
Background: The Occupational Safety and Health Monitoring and Assessment Tool (OSH-MAT) is a practical instrument that is currently used in the German woodworking and metalworking industries to monitor safety conditions at workplaces. The 12-item scoring system has three subscales rating technical, organizational, and personnel-related conditions in a company. Each item has a rating value ranging from 1 to 9, with higher values indicating higher standard of safety conditions. Methods: The reliability of this instrument was evaluated in a cross-sectional survey among 128 companies and its validity among 30,514 companies...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928398/hydrogen-rich-solution-attenuates-myocardial-injury-caused-by-cardiopulmonary-bypass-in-rats-via-the-janus-activated-kinase-2-signal-transducer-and-activator-of-transcription-3-signaling-pathway
#3
Keyan Chen, Yingjie Sun, Yugang Diao, Tiezheng Zhang, Wanwei Dong
The incidence of complications and mortality following open-heart surgery with cardiopulmonary bypass (CPB) is associated with the severity of the myocardial injury that occurs during surgery. Hydrogen-rich solution (HRS) may prevent antioxidant stress and inhibit apoptosis and inflammation. The present study was designed to investigate the effects of HRS on CPB-induced myocardial injury, and to investigate its potential regulation of the Janus-activated kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29927909/self-reported-concussions-from-playing-a-sport-or-being-physically-active-among-high-school-students-united-states-2017
#4
Lara DePadilla, Gabrielle F Miller, Sherry Everett Jones, Alexis B Peterson, Matthew J Breiding
Increased susceptibility to concussions and longer recovery times among high school athletes compared with older athletes (1) make concussions among youths playing a sport or being physically active an area of concern. Short-term and long-term sequelae of concussions can include cognitive, affective, and behavioral changes (1). Surveillance methods used to monitor concussions among youths likely underestimate the prevalence. Estimates assessed from emergency departments miss concussions treated outside hospitals, those generated using high school athletic trainer reports miss concussions sustained outside of school-based sports (2), and both sources miss medically untreated concussions...
June 22, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29927680/exploring-substance-use-and-impaired-driving-among-adults-aged-21-years-and-older-in-the-us-2015
#5
Amy Jewett, Alexis B Peterson, Erin K Sauber-Schatz
INTRODUCTION: Alcohol or drug impaired driving can cause motor vehicle crashes, injuries, and death. Estimates of drug impaired driving are difficult to obtain. This study explores self-reported prevalence of and factors associated with alcohol, marijuana, and prescription opioid use and impaired driving among adults aged 21 years and older in the U.S. METHODS: Self-reported data from 3,383 adults in the 2015 Fall ConsumerStyles survey were analyzed. Respondents were asked about alcohol, marijuana, and prescription opioid use and driving while impaired in the last 30 days...
June 21, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29927642/nonsuicidal-self-injury-among-a-representative-sample-of-us-adolescents-2015
#6
Martin A Monto, Nick McRee, Frank S Deryck
OBJECTIVES: To provide prevalence estimates of adolescent nonsuicidal self-injury (NSSI) based on large, representative, nonclinical samples of high-school students, and to explore gender differences in health risks associated with NSSI. METHODS: We used 2015 Centers for Disease Control and Prevention Youth Risk Behavior Surveillance System data to estimate the prevalence of self-injury and variables potentially associated with self-injury for high-school-age boys (n = 32 150) and girls (n = 32 521) in 11 US states...
June 21, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29927630/rollover-injury-in-vehicles-with-high-strength-to-weight-ratio-swr-roofs-curtain-and-side-airbags-and-other-safety-improvements
#7
David C Viano, Chantal S Parenteau
PURPOSE: This study investigated trends in severe injury and ejection in rollover crashes involving lap-shoulder belted drivers and right-front passengers. It was conducted because of changes in 2009 to consumer information programs and regulations related to rollover protection. The data is presented by model year (MY) of the vehicle in groups from 1995-2016. NASS-CDS cases with 2010-16 MY vehicles were also evaluated to determine the crash circumstances and causes for severe injury of belted occupants in vehicles with a high strength-to-weight (SWR) roof, curtain and side airbags and other safety improvements...
June 21, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29926831/retinoid-x-receptor-%C3%AE-downregulation-is-required-for-tail-and-caudal-spinal-cord-regeneration-in-the-adult-newt
#8
Sarah E Walker, Rachel Nottrodt, Lucas Maddalena, Christopher Carter, Gaynor E Spencer, Robert L Carlone
Some adult vertebrate species, such as newts, axolotls and zebrafish, have the ability to regenerate their central nervous system (CNS). However, the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not well understood. Recent evidence supports a role for retinoid signaling in the intrinsic ability of neurons, in these regeneration-competent species, to regrow after CNS injury. Previously, we demonstrated that a specific retinoic acid receptor (RAR) subtype, RARβ, mediates the effects of endogenous retinoic acid (RA) on neuronal growth and guidance in the adult newt CNS after injury...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29926818/protective-effects-of-gonadal-hormones-on-spinal-motoneurons-following-spinal-cord-injury
#9
REVIEW
Dale R Sengelaub, Xiao-Ming Xu
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. The majority of treatment strategies after SCI have concentrated on the damaged spinal cord, for example working to reduce lesion size or spread, or encouraging regrowth of severed descending axonal projections through the lesion, hoping to re-establish synaptic connectivity with caudal targets. In our work, we have focused on a novel target for treatment after SCI, surviving spinal motoneurons and their target musculature, with the hope of developing effective treatments to preserve or restore lost function following SCI...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29926659/-effects-of-coriaria-sinica-maxim-s-extract-on-microcirculation-and-oxidative-stress-of-wounds-in-rats-with-deep-second-degree-burn
#10
Ze-Hua Hu, Zhao-Fen Yu, Jin Huang, Xue-Fei Chen, De-Bin Huang
OBJECTIVE: To investigate the effects of Coriaria Sinica Maxim's extract(CSME) on microcirculation and oxidative stress of wounds in rats with deep second-degree burn. METHODS: One hundred and eighty rats were randomly divided into normal saline group(NS), white petroleum group(WPL), silver sulfadiazine group (SSD), Coriariasinica Maxim's extract group which were divided into low dose(CSME-L),middle dose(CSME-M) and high dose(CSME-H). After anesthesia with burn instrument to burn the hair removal area of rats, these wounds were confirmed by pathological results with deep second degree burns...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926545/the-effects-of-retinoic-acid-and-mapk-inhibitors-on-phosphorylation-of-smad2-3-induced-by-transforming-growth-factor-%C3%AE-1
#11
Sang Hoon Lee, Ju Hye Shin, Mi Hwa Shin, Young Sam Kim, Kyung Soo Chung, Joo Han Song, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Joon Chang, Moo Suk Park
BACKGROUND: Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect of RA and the role of these signaling molecules on the phosphorylation of Smad2/3 (p-Smad2/3) induced by TGF-β1. METHODS: A549 epithelial cells and CCD-11Lu fibroblasts were incubated and stimulated with or without all-trans RA (ATRA) and TGF-β1 and with MAPK or MEK inhibitors...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29925226/treatment-of-intractable-parotid-sialocele-occurred-after-open-reduction-fixation-of-mandibular-subcondylar-fracture
#12
Jungil Hwang, Yong Chun You, Jin Sik Burm
A sialocele is a subcutaneous cavity containing saliva, most often caused by facial trauma or iatrogenic complications. In subcondylar fractures, most surgeons are conscious of facial nerve injury; however, they usually pay little attention to the parotid duct injury. We report the case of a 41-year-old man with a sialocele, approximately 5×3 cm in size, which developed 1 week after subcondylar fracture reduction. The sialocele became progressively enlarged despite conservative management. Computed tomography showed a thin-walled cyst between the body and tail of the parotid gland...
June 22, 2018: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29924722/interaction-of-volatile-organic-compounds-and-underlying-liver-disease-a-new-paradigm-for-risk
#13
Anna L Lang, Juliane I Beier
Occupational and environmental exposures to industrial chemicals are known to cause hepatotoxicity and liver injury, in humans and in animal models. Historically, research has focused on severe acute liver injury (e.g., fulminant liver failure) or endstage diseases (e.g., cirrhosis and HCC). However, it has become recently recognized that toxicants can cause more subtle changes to the liver. For example, toxicant-associated steatohepatitis (TASH), characterized by hepatic steatosis, and inflammation, was recently recognized in an occupational cohort exposed to vinyl chloride...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29923903/pressure-injury-risk-factors-in-critical-care-patients-a-descriptive-analysis
#14
Jill Cox, Sharon Roche, Virginia Murphy
BACKGROUND: Pressure injury (PI) development in the critical care population is multifactorial. Despite the application of evidence-based prevention strategies, PIs do occur and may be unavoidable in some patients. OBJECTIVES: To describe the risk factors associated with PI development in a sample of medical-surgical intensive care unit patients and determine whether these risk factors were congruent with the risk factors proposed in the work of the National Pressure Ulcer Advisory Panel on unavoidable PIs...
July 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#15
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923765/physiological-functions-of-ferroportin-in-the-regulation-of-renal-iron-recycling-and-ischemic-acute-kidney-injury
#16
Xueqiao Wang, Xiaoqing Zheng, Juanlian Zhang, Shifeng Zhao, Zhigang Wang, Fudi Wang, Wenjun Shang, Jonathan Barasch, Andong Qiu
Renal iron recycling preserves the filtered iron from urinary excretion. However, it remains debated whether ferroportin (FPN), the solely known iron exporter, is functionally involved in renal iron recycling, and whether renal iron recycling is required for systemic iron homeostasis. We deleted FPN in the whole nephrons using a Nestin-Cre and in the distal nephrons and collecting ducts using a Ksp-Cre, and investigated its impacts on renal iron recycling and systemic iron homeostasis. FPN deletion by Nestin-Cre but not by Ksp-Cre caused excess iron retention and increased ferritin heavy chain (FTH1) specifically in the proximal tubules, and resulted in the reduction of serum and hepatic iron...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923371/laser-safety-in-fiber-optic-monitoring-of-spinal-cord-hemodynamics-a-preclinical-evaluation
#17
David R Busch, James Davis, Angela Kogler, Robert M Galler, Ashwin B Parthasarathy, Arjun G Yodh, Thomas F Floyd
The prevention and treatment of spinal cord injury are focused upon the maintenance of spinal cord blood flow, yet no technology exists to monitor spinal cord ischemia. We recently demonstrated continuous monitoring of spinal cord ischemia with diffuse correlation and optical spectroscopies using an optical probe. Prior to clinical translation of this technology, it is critically important to demonstrate the safety profile of spinal cord exposure to the required light. To our knowledge, this is the first report of in situ safety testing of such a monitor...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29922980/why-do-we-use-arthroscopy-for-distal-radius-fractures
#18
REVIEW
Ludovic Ardouin, Alexandre Durand, André Gay, Marc Leroy
The management of distal radius fractures needs to be adapted to the increasingly complex traumas in patients with greater functional requirements. The goal remains to restore normal anatomy in order to preserve function. A pre-operative assessment using x-rays and thin-slice CT scans with three-dimensional reconstructions enables the best possible understanding of the fracture prior to surgery and planning of the pre-operative strategy. Arthroscopy is a technique that allows visualisation of the bone fragments and their displacement, as well as their reduction...
June 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29922941/cardioprotective-and-functional-effects-of-levosimendan-and-milrinone-in-mice-with-cecal-ligation-and-puncture-induced-sepsis
#19
Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori
Levosimendan and milrinone may be used in place of dobutamine to increase cardiac output in septic patients with a low cardiac output due to impaired cardiac function. The effects of the two inotropic agents on cardiac inflammation and left ventricular (LV) performance were examined in mice with cecal ligation and puncture (CLP)-induced sepsis. CLP mice displayed significant cardiac inflammation, as indicated by highly increased pro-inflammatory cytokines and neutrophil infiltration in myocardial tissues. When continuously given, levosimendan prevented but milrinone exaggerated cardiac inflammation, but they significantly reduced the elevations in plasma cardiac troponin-I and heart-type fatty acid-binding protein, clinical markers of cardiac injury...
June 20, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29922788/photobiomodulation-prevents-dna-fragmentation-of-alveolar-epithelial-cells-and-alters-the-mrna-levels-of-caspase-3-and-bcl-2-genes-in-acute-lung-injury
#20
Luiz Philippe da Silva Sergio, Andrezza Maria Côrtes Thomé, Larissa Alexsandra da Silva Neto Trajano, Andre Luiz Mencalha, Adenilson de Souza da Fonseca, Flávia de Paoli
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are defined as pulmonary inflammation that could occur from sepsis and lead to pulmonary permeability and alveolar edema making them life-threatening diseases. Photobiomodulation (PBM) properties have been widely described in the literature in several inflammatory diseases; although the mechanisms of action are not always clear, this could be a possible treatment for ARDS/ALI. Thus, the aim of this study was to evaluate the mRNA levels from caspase-3 and BCL-2 genes and DNA fragmentation in lung tissue from Wistar rats affected by ALI and subjected to photobiomodulation by exposure to a low power infrared laser (808 nm; 100 mW; 3...
June 20, 2018: Photochemical & Photobiological Sciences
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