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Depression epilepsy

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https://www.readbyqxmd.com/read/29653194/chronic-agomelatine-treatment-prevents-comorbid-depression-in-the-post-status-epilepticus-model-of-acquired-epilepsy-through-suppression-of-inflammatory-signaling
#1
Jana Tchekalarova, Dimitrinka Atanasova, Lidia Kortenska, Milena Atanasova, Nikolai Lazarov
Inflammatory signal molecules are suggested to be involved in the mechanism underlying comorbid depression in epilepsy. In the present study, we tested the hypothesis that the novel antidepressant agomelatine, a potent melatonin MT1 and MT2 receptor agonist and serotonin 5HT2C receptor antagonist, can prevent depressive symptoms developed during the chronic epileptic phase by suppressing an inflammatory response. Chronic treatment with agomelatine (40 mg/kg, i.p.) was initiated an hour after the kainate acid (KA)-induced status epilepticus (SE) and maintained for a period of 10 weeks in Wistar rats...
April 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29651976/screening-for-anxiety-and-depression-in-epilepsy
#2
Aileen McGonigal, Jean-Arthur Micoulaud-Franchi
No abstract text is available yet for this article.
April 13, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29616151/narcolepsy-in-adolescence-a-missed-diagnosis-a-case-report
#3
Anoop K Gupta, Swapnajeet Sahoo, Sandeep Grover
<b/> Narcolepsy is an uncommon sleep cycle disorder with a usual onset in adolescence, but it is often misdiagnosed and underdiagnosed. Rarely is the tetrad of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis seen in patients. The clinical characteristics of narcolepsy are often confused with many psychiatric and neurologic disorders. Lack of clinical awareness about narcolepsy leads to frequent prescriptions of antiepileptics and psychotropics, which can adversely affect the quality of life of children and adolescents...
July 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29609146/effects-of-a-psychotherapeutic-group-intervention-in-patients-with-refractory-mesial-temporal-lobe-epilepsy-and-comorbid-psychogenic-nonepileptic-seizures-a-nonrandomized-controlled-study
#4
Amanda Cristian Serafim de Barros, Ana Eliza Romano Furlan, Lucia Helena Neves Marques, Gerardo Maria de Araújo Filho
PURPOSE: Psychogenic nonepileptic seizures (PNES) are paroxysmal episodes superficially resembling epileptic seizures but are not associated with any electrical abnormalities. Despite the existence of recent evidence addressing psychological interventions on PNES, there is a scarcity of studies investigating such interventions on patients with dual diagnoses, such as in temporal lobe epilepsy/mesial temporal sclerosis (TLE-MTS) with comorbid PNES; TLE-MTS is a very frequent epilepsy syndrome found in tertiary centers...
March 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29608654/the-ventrolateral-medulla-and-medullary-raphe-in-sudden-unexpected-death-in-epilepsy
#5
Smriti Patodia, Alyma Somani, Megan O'Hare, Ranjana Venkateswaran, Joan Liu, Zuzanna Michalak, Matthew Ellis, Ingrid E Scheffer, Beate Diehl, Sanjay M Sisodiya, Maria Thom
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in patients with epilepsy. One hypothesis proposes that sudden death is mediated by post-ictal central respiratory depression, which could relate to underlying pathology in key respiratory nuclei and/or their neuromodulators. Our aim was to investigate neuronal populations in the ventrolateral medulla (which includes the putative human pre-Bötzinger complex) and the medullary raphe. Forty brainstems were studied comprising four groups: 14 SUDEP, six epilepsy controls, seven Dravet syndrome cases and 13 non-epilepsy controls...
March 28, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29604188/maternal-care-exerts-disease-modifying-effects-on-genetic-absence-epilepsy-and-comorbid-depression
#6
Karine Yu Sarkisova, Alla V Gabova
WAG/Rij rats, a genetic animal model of absence epilepsy with comorbidity of depression, exhibit behavioral depression-like symptoms and spontaneous generalized spike-wave discharges (SWDs) in the EEG at the age of 6-8 months. The aim of the present study was to test the hypothesis that maternal care is an environmental factor which, along with genetic predisposition, may contribute to the expression of absence seizures and depression-like comorbidity later in life. To achieve this, a cross-fostering procedure was used...
March 31, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29600825/depression-comorbidity-in-epileptic-rats-is-related-to-brain-glucose-hypometabolism-and-hypersynchronicity-in-the-metabolic-network-architecture
#7
Gabriele Zanirati, Pamella Nunes Azevedo, Gianina Teribele Venturin, Samuel Greggio, Allan Marinho Alcará, Eduardo R Zimmer, Paula Kopschina Feltes, Jaderson Costa DaCosta
OBJECTIVE: Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy syndromes in the world. Depression is an important comorbidity of epilepsy, which has been reported in patients with TLE and in different experimental models of epilepsy. However, there is no established consensus on which brain regions are associated with the manifestation of depression in epilepsy. Here, we investigated the alterations in cerebral glucose metabolism and the metabolic network in the pilocarpine-induced rat model of epilepsy and correlated it with depressive behavior during the chronic phase of epilepsy...
March 30, 2018: Epilepsia
https://www.readbyqxmd.com/read/29590727/nonverbal-memory-capacity-in-persons-with-epilepsy-is-associated-with-depression-rather-than-anxiety
#8
Krunoslav Matešić, Meri Tadinac, Hrvoje Hećimović
Epilepsy is characterized by repeated epileptic seizures, which are manifested in various ways and depend on the location and size of foci in the brain. Long-term seizures with secondary generalization can cause memory problems. Numerous studies demonstrate the connection of memory damage and lateralization in medial temporal lobe epilepsy (TLE). However, the results were not always consistent with the material-specific memory model. A possible explanation for these inconsistent data is the insufficient control of psychological variables that can affect memory...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29590213/stochastic-vagus-nerve-stimulation-affects-acute-heart-rate-dynamics-in-rats
#9
Steven W Lee, Kanchan Kulkarni, Elizabeth M Annoni, Imad Libbus, Bruce H KenKnight, Elena G Tolkacheva
Vagus nerve stimulation (VNS) is an approved therapy for treatment of epilepsy and depression. While also shown to be promising in several preclinical and clinical studies to treat cardiovascular diseases, optimal therapeutic stimulation paradigms are still under investigation. Traditionally, parameters such as frequency, current, and duty cycle are used to adjust the efficacy of VNS therapy. This study explored the effect of novel stochastic VNS (S-VNS) on acute heart rate (HR) dynamics. The effect of S-VNS was evaluated in Sprague Dawley rats by comparing the acute HR and HR variability (HRV) responses to standard, periodic VNS (P-VNS) across different frequencies (FREQs, 10-30 Hz)...
2018: PloS One
https://www.readbyqxmd.com/read/29589874/genome-editing-in-neuroepithelial-stem-cells-to-generate-human-neurons-with-high-adenosine-releasing-capacity
#10
Daniel Poppe, Jonas Doerr, Marion Schneider, Ruven Wilkens, Julius A Steinbeck, Julia Ladewig, Allison Tam, David E Paschon, Philip D Gregory, Andreas Reik, Christa E Müller, Philipp Koch, Oliver Brüstle
As a powerful regulator of cellular homeostasis and metabolism, adenosine is involved in diverse neurological processes including pain, cognition, and memory. Altered adenosine homeostasis has also been associated with several diseases such as depression, schizophrenia, or epilepsy. Based on its protective properties, adenosine has been considered as a potential therapeutic agent for various brain disorders. Since systemic application of adenosine is hampered by serious side effects such as vasodilatation and cardiac suppression, recent studies aim at improving local delivery by depots, pumps, or cell-based applications...
March 28, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29580558/prevalence-and-predictors-of-depression-among-patients-with-epilepsy-stroke-and-multiple-sclerosis-using-the-cleveland-clinic-knowledge-program-within-the-neurological-institute
#11
Adele C Viguera, Youran Fan, Nicolas R Thompson, Brittany Lapin, Alexander Chaitoff, Sandra D Griffith, Deborah M Miller, Lara Jehi, Irene L Katzan
BACKGROUND: Neurological conditions carry a high risk of depression. Given this risk, the Neurological Institute (NI) at Cleveland Clinic has initiated systematic screening for depression using the 9-item Patient Health Questionnaire-9 (PHQ-9) embedded within its electronic medical record and its data capture system, the Knowledge Program (KP)1 . OBJECTIVE: We sought to (1) estimate the prevalence of depression among patients with epilepsy, stroke, and multiple sclerosis (MS); (2) identify risk factors for depression within each disease; and (3) determine differential risks and predictors across neurological disorders...
December 13, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29579553/a-systematic-review-of-quality-of-life-in-parents-of-children-with-epilepsy
#12
REVIEW
Klajdi Puka, Tamara P Tavares, Kelly K Anderson, Mark A Ferro, Kathy N Speechley
OBJECTIVES: This systematic review aimed to 1) describe the quality of life (QOL) of parents of children with childhood-onset epilepsy (CWE), 2) identify factors associated with parental QOL, and 3) evaluate the association between parents' QOL and children's psychological well-being. METHODS: We conducted a comprehensive search of MEDLINE, EMBASE, and PsycINFO and conducted forward and backward citation tracking. A total of 15 articles met inclusion criteria. Parents' QOL was compared with population norms, healthy controls, and parents of children with other chronic conditions...
March 23, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29576433/cognitive-and-clinical-variables-associated-with-interictal-dysphoric-disorder-in-patients-with-epilepsy
#13
Gloria Tedrus, Rafael de Lima Silva
PURPOSE: The relationship between interictal dysphoric disorder (IDD) and cognitive impairment in adult patients with epilepsy (PWE) is poorly studied. METHODS: The Interictal Dysphoric Disorder Inventory (IDDI) with cognitive and clinical aspects was compared with Quality of Life in Epilepsy Inventory (QOLIE-31) and Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) scores of 117 PWE at significance level p<0.05. RESULTS: Interictal dysphoric disorder occurred in 25 (21...
March 22, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29574297/gender-differences-in-prevalence-of-psychiatric-disorders-levels-of-alexithymia-and-coping-strategies-in-patients-with-refractory-mesial-temporal-epilepsy-and-comorbid-psychogenic-nonepileptic-seizures
#14
Amanda Cristian Serafim de Barros, Ana Eliza Romano Furlan, Lucia Helena Neves Marques, Gerardo Maria de Araújo Filho
OBJECTIVE: The objective of this study was to investigate the psychological aspects and psychiatric disorders (PDs) in patients dually diagnosed with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS) with psychogenic nonepileptic seizures (PNES) treated in a tertiary center in order to find any gender differences in psychiatric, clinical, and sociodemographic characteristics. METHOD: Psychiatric assessment was performed through the Diagnostic and Statistical Manual for Psychiatric Disorders - 5th edition (DSM-5)...
March 22, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29574226/role-of-asic1a-in-a%C3%AE-induced-synaptic-alterations-in-the-hippocampus
#15
D Mango, R Nisticò
Acid-sensing ion channels (ASICs) are widely expressed in the mammalian central nervous system where they play a key role in synaptic transmission and in specific forms of memory. On the other hand, ASICs can be persistently active under pathological conditions contributing to neuronal damage in ischemic stroke, brain trauma, epilepsy and Parkinson's disease. However, to date no experimental evidence has linked ASICs to Alzheimer's disease (AD). Aim of the present work was to investigate, in CA1 pyramidal neurons, the possible involvement of ASIC1a in the Aβ-mediated effect on metabotropic glutamate (mGlu) receptor dependent transmission...
March 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29573759/executive-dysfunction-and-depression-in-pediatric-temporal-lobe-epilepsy-the-contribution-of-hippocampal-sclerosis-and-psychosocial-factors
#16
William A Schraegle, Nancy L Nussbaum, Jeffrey B Titus
OBJECTIVES: Temporal lobe epilepsy (TLE) has been identified as a risk factor for increased depression features in children and adolescents; however, less is known regarding specific neurocognitive predictors of depression in this population above and beyond seizure-specific and sociodemographic factors. METHODS: The study included 62 patients with TLE (64% male) aged 8 to 16 years (M=12.62; SD=2.26) who underwent comprehensive neuropsychological evaluation. RESULTS: Correlation analyses revealed significant association between patient depression and WCST Total Perseverations, BRIEF Behavioral Regulation Index (BRI) and family stress...
March 25, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29565957/association-of-higher-migraine-risk-among-female-and-younger-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-of-one-million
#17
Jiunn-Horng Chen, Shih-Chi Wu, Chih-Hsin Muo, Chia-Hung Kao, Chun-Hung Tseng, Chon-Haw Tsai
BACKGROUND: Inflammation may trigger migraine development through neurovascular reactions in the brain. Most of the migraine patients, particularly the younger ones, do not have any risk factors for this disease. Hence, we assessed whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases the risk of migraine. OBJECTIVE: We aim to evaluate the risk of migraine among female and middle-age COM patients with a large patient sample. STUDY DESIGN: A retrospective cohort study was conducted in this study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29562209/depression-in-people-with-epilepsy-how-much-do-asian-colleagues-acknowledge-it
#18
REVIEW
Ali A Asadi-Pooya, Kousuke Kanemoto, Oh-Young Kwon, Go Taniguchi, Zhou Dong, Yotin Chinvarun, Hsiang-Yu Yu, Aileen McGonigal, Andres Miguel Kanner, Sung-Pa Park
PURPOSE: The purpose of this review was to investigate the prevalence of depression in people with epilepsy (PWE) in different countries in Asia. METHODS: We searched the electronic database PubMed on June 13, 2017 for articles in English that included the following search terms: "epilepsy" AND "depression" AND "country name" for all Asian countries since 1947. Relevant original studies from Asia were included if they reported the prevalence of depression in PWE...
March 12, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29558564/systems-approaches-to-optimizing-deep-brain-stimulation-therapies-in-parkinson-s-disease
#19
REVIEW
Sabato Santaniello, John T Gale, Sridevi V Sarma
Over the last 30 years, deep brain stimulation (DBS) has been used to treat chronic neurological diseases like dystonia, obsessive-compulsive disorders, essential tremor, Parkinson's disease, and more recently, dementias, depression, cognitive disorders, and epilepsy. Despite its wide use, DBS presents numerous challenges for both clinicians and engineers. One challenge is the design of novel, more efficient DBS therapies, which are hampered by the lack of complete understanding about the cellular mechanisms of therapeutic DBS...
March 20, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29553383/the-roles-of-surgery-and-technology-in-understanding-focal-epilepsy-and-its-comorbidities
#20
REVIEW
Dennis D Spencer, Jason L Gerrard, Hitten P Zaveri
Intracranial electrophysiological recording in patients with refractory focal epilepsy is the gold standard for defining epileptogenic tissue. Although the concordance of intracranial electrophysiology, structural MRI, and pathology can identify brain regions for resection, complete seizure control after surgery is not achieved in all patients with focal epilepsy. Repetitive identical behavioural seizures suggest one onset area, but epileptogenesis might be distributed and connected by functional and structural brain networks outside the seizure onset area, which could explain poor postsurgical outcomes in some patients...
April 2018: Lancet Neurology
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