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Coronary calcium

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https://www.readbyqxmd.com/read/29225032/calcification-of-thoracic-and-abdominal-aneurysms-is-associated-with-mortality-and-morbidity
#1
Mohammed M Chowdhury, Lukasz P Zieliński, James J Sun, Simon Lambracos, Jonathan R Boyle, Seamus C Harrison, James H F Rudd, Patrick A Coughlin
INTRODUCTION: Cardiovascular events are common in people with aortic aneurysms. Arterial calcification is a recognised predictor of cardiovascular outcomes in coronary artery disease. Whether calcification within abdominal and thoracic aneurysm walls is correlated with poor cardiovascular outcomes is not known. PATIENTS AND METHODS: Calcium scores were derived from computed tomography (CT) scans of consecutive patients with either infrarenal (AAA) or descending thoracic aneurysms (TAA) using the modified Agatston score...
December 7, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29221768/current-interpretation-of-myocardial-stunning
#2
REVIEW
Andrea Igoren Guaricci, Gabriella Bulzis, Gianluca Pontone, Pietro Scicchitano, Rossella Carbonara, Mark Rabbat, Delia De Santis, Marco Matteo Ciccone
Myocardial stunning is a temporary post-ischemic cardiac mechanical dysfunction. As such, it is a heterogeneous entity and different conditions can promote its occurrence. Transient coronary occlusion, increased production of catecholamines and endothelin, and myocardial inflammation are all possible causes of myocardial stunning. Possible underlying mechanisms include an oxyradical hypothesis, calcium overload, decreased responsiveness of myofilaments to calcium, and excitation-contraction uncoupling due to sarcoplasmic reticulum dysfunction...
November 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29220061/comparison-of-carotid-intima-media-thickness-and-coronary-artery-calcium-score-for-estimating-subclinical-atherosclerosis-in-patients-with-fatty-liver-disease
#3
Hyun-Jin Kim, Hyung-Bok Park, Yongsung Suh, Yoon-Hyeong Cho, Eui-Seok Hwang, Deok-Kyu Cho, Tae-Young Choi
INTRODUCTION: Fatty liver disease (FLD) is correlated with cardiovascular disease. Carotid intima-media thickness (CIMT) and coronary artery calcium score (CACS) can noninvasively identify subclinical atherosclerosis and predict risk for cardiovascular events. This study evaluated CIMT and CACS measurements to detect subclinical atherosclerosis in patients with and without FLD. METHODS: Patients who underwent carotid and abdominal ultrasounds as well as cardiac computed tomography (CT) scans were evaluated retrospectively...
December 8, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#4
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29208769/association-between-the%C3%A2-timd4-havcr1-variants-and-serum-lipid-levels-coronary-heart-disease-and-ischemic-stroke-risk-and-atorvastatin-lipid-lowering-efficacy
#5
Qing-Hui Zhang, Rui-Xing Yin, Wu-Xian Chen, Xiao-Li Cao, Yu-Ming Chen
Little is known about the association of the TIMD4-HAVCR1 variants and lipid metablism, the risk of coronary heart disease (CHD) and ischemic stroke (IS). This study aimed to determine the TIMD4-HAVCR1 variants, their haplotypes and gene-environment interactions on serum lipid levels, the risk of CHD and IS, and the lipid-lowering efficacy of atorvastatin in a southern Chinese Han population. Genotypes of 3 variants in 622 controls, 579 CHD and 546 IS patients were determined by the Snapshot technology. Atorvastatin calcium tablet (20 mg/d) was given in 724 hyperlipidemic patients for 8 weeks after genotyping...
December 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29202484/usefulness-of-martin-s-method-for-estimation-of-low-density-lipoprotein-cholesterol-in-coronary-atherosclerosis
#6
Soie Chung
OBJECTIVE: This study was conducted to validate Martin's method in coronary atherosclerosis in comparison with Friedewald's equation. SUBJECTS AND METHODS: A total of 299 participants with a coronary artery calcium score (CACS) ≥ 300 and a serum triglyceride (TG) level < 400 mg/dL at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea were enrolled in this study. The Low-density lipoprotein cholesterol (LDL-C) was directly measured with a homogeneous assay (DLDL) and estimated by both Friedewald's equation (FLDL) and Martin's method (MLDL)...
December 4, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29198984/relation-of-an-echocardiographic-based-cardiac-calcium-score-to-mitral-stenosis-severity-and-coronary-artery-disease-in-patients-with-severe-aortic-stenosis
#7
Siyuan P Sheng, Lucius A Howell, Melissa C Caughey, Michael Yeung, John P Vavalle
Patients with calcific aortic stenosis (AS) often have diffuse cardiac calcification involving the mitral valve apparatus and coronary arteries. We examined the association between global cardiac calcification quantified by a previously validated echocardiographic calcium score (eCS) with the severity of mitral stenosis (MS) and coronary artery disease (CAD) in patients with a clinical diagnosis of severe calcific AS. In this sample of 147 patients (mean age 81 ± 9 years, 50% male), 81 patients (55%) were determined by echocardiography to have some degree of MS...
October 26, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29196542/cardiac-myosin-binding-protein-c-is-a-novel-marker-of-myocardial-injury-and-fibrosis-in-aortic-stenosis
#8
Atul Anand, Calvin Chin, Anoop S V Shah, Jacek Kwieciński, Alex Vesey, Joanna Cowell, Ekkehard Weber, Thomas Kaier, David E Newby, Marc Dweck, Michael S Marber, Nicholas L Mills
OBJECTIVE: Cardiac myosin-binding protein C (cMyC) is an abundant sarcomeric protein and novel highly specific marker of myocardial injury. Myocyte death characterises the transition from hypertrophy to replacement myocardial fibrosis in advanced aortic stenosis. We hypothesised that serum cMyC concentrations would be associated with cardiac structure and outcomes in patients with aortic stenosis. METHODS: cMyC was measured in two cohorts in which serum had previously been prospectively collected: a mechanism cohort of patients with aortic stenosis (n=161) and healthy controls (n=46) who underwent cardiac MRI, and an outcome cohort with aortic stenosis (n=104) followed for a median of 11...
December 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29195787/high-risk-plaque-and-calcification-detected-by-coronary-ct-angiography-to-predict-future-cardiovascular-events-after-percutaneous-coronary-intervention
#9
Nobuo Tomizawa, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
RATIONALE AND OBJECTIVES: The purpose of this study was to investigate whether high-risk plaque (HRP) and calcium assessed by coronary computed tomography (CT) could predict future cardiovascular events after second-generation drug-eluting stent (DES) placement. MATERIALS AND METHODS: We analyzed 317 patients from December 2012 to April 2015 who underwent coronary CT followed by DES placement. HRP was defined as a plaque with positive remodeling and low attenuation or a plaque with a napkin-ring sign...
November 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29195505/type-2-diabetes-mellitus-is-associated-with-a-lower-fibrous-cap-thickness-but-has-no-impact-on-calcification-morphology-an-intracoronary-optical-coherence-tomography-study
#10
Andrea Milzi, Mathias Burgmaier, Kathrin Burgmaier, Martin Hellmich, Nikolaus Marx, Sebastian Reith
BACKGROUND: Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this study aimed to compare differences of coronary plaque morphology in patients with and without T2DM with a particular focus on coronary calcification...
December 1, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29192457/-pharmacological-mechanism-analysis-of-oligopeptide-from-pinctada-fucata-based-on-in-silico-proteolysis-and-protein-interaction-network
#11
Jin-Long Duan, Kui-Wu Yao, Xiao-Xiao Feng, Jue Cao, Zhou Yu
Thoracic obstruction is mainly attributed to the scope of coronary heart disease in modern medicine, and traditional Chinese medicine(TCM) shows a significant effect in the treatment of thoracic obstruction. In this research, a network pharmacology method was carried out to systemically study the underlying mechanism of the core herbal compatibility in TCM on the thoracic obstruction. First, we collected the literature about TCM prescriptions for treating thoracic obstruction from CNKI. Then, a prescription database was establish by TCM inheritance support platform system(V2...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29189397/patterns-of-coronary-calcification-and-their-impact-on-the-diagnostic-accuracy-of-computed-tomography-coronary-angiography
#12
Dariusz Noll, Mariusz Kruk, Marcin Demkow, Jerzy Pręgowski, Edyta Kaczmarska, Karolina Kryczka, Radosław Pracoń, Zofia Dzielińska, Justyna Śleszycka, Adam Witkowski, Witold Rużyłło, Cezary Kępka
OBJECTIVE: Despite coronary calcifications being a major factor affecting the diagnostic accuracy of coronary computed tomography angiography (CTA), there is a lack of established criteria for categorizing calcifications. We aimed to evaluate patterns of coronary calcification based on quantitative radiodensity and size parameters to provide coronary calcium categories and assess their impact on the accuracy of coronary CTA. METHODS AND RESULTS: We analyzed length, maximum thickness, volume, mean density, and maximum density of coronary calcium and divided each of these parameters into tertiles...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29188297/coronary-calcium-score-and-cardiovascular-risk-in-elderly-populations-further-considerations
#13
Julio C Sauza-Sosa, Victor A Ferrari, Lilia M Sierra-Galan
No abstract text is available yet for this article.
November 29, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29188289/coronary-calcium-score-and-cardiovascular-risk-in-elderly-populations-reply
#14
Philip Greenland, Yuichiro Yano, Donald M Lloyd-Jones
No abstract text is available yet for this article.
November 29, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29183566/application-of-pressure-derived-myocardial-fractional-flow-reserve-in-chronic-hemodialysis-patients
#15
Kimihiko Hirose, Taishiro Chikamori, Satoshi Hida, Nobuhiro Tanaka, Jun Yamashita, Yuko Igarashi, Tetsushi Saitoh, Hirokazu Tanaka, Akira Yamashina
BACKGROUND: Although fractional flow reserve (FFR) measurements during coronary angiography are performed in routine clinical practice, few studies have evaluated FFR measurements in dialysis patients. METHODS: We retrospectively studied 42 hemodialysis patients with suspected or known coronary artery disease (CAD) who underwent stress myocardial perfusion imaging and coronary angiography with FFR measurements for 61 coronary lesions. The cut-off value for FFR to detect myocardial ischemia was determined by receiver operating characteristic (ROC) curve analysis...
January 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29174140/relation-of-coronary-artery-calcium-and-extra-coronary-aortic-calcium-to-incident-hypertension-from-the-multi-ethnic-study-of-atherosclerosis
#16
Amer I Aladin, Mahmoud Al Rifai, Shereen H Rasool, Zeina Dardari, Joseph Yeboah, Khurram Nasir, Matthew J Budoff, Bruce M Psaty, Roger S Blumenthal, Michael J Blaha, John W McEvoy
Arterial calcification reflects an atherosclerotic process associated with vascular stiffness. Whether baseline coronary artery calcium (CAC) and extra-coronary calcium (ECC), measured using noncontrast computed tomography imaging, are associated with incident hypertension is poorly understood. We studied participants from the Multi-Ethnic Study of Atherosclerosis without measured or self-reported hypertension at baseline. Incident hypertension was defined by blood pressure criteria (BP, ≥140/90 mmHg), BP medication use, or both, and was assessed at in-person visits...
October 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29171773/fitness-attenuates-the-prevalence-of-increased-coronary-artery-calcium-in-individuals-with-metabolic-syndrome
#17
Elin Ekblom-Bak, Örjan Ekblom, Erika Fagman, Oskar Angerås, Caroline Schmidt, Annika Rosengren, Mats Börjesson, Göran Bergström
Background The association between cardiorespiratory fitness, physical activity and coronary artery calcium (CAC) is unclear, and whether higher levels of fitness attenuate CAC prevalence in subjects with metabolic syndrome is not fully elucidated. The present study aims to: a) investigate the independent association of fitness on the prevalence of CAC, after adjustment for moderate-to-vigorous physical activity and sedentary time, and b) study the possible attenuation of increased CAC by higher fitness, in participants with metabolic syndrome...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29168268/lifetime-marijuana-use-and-subclinical-atherosclerosis-the-coronary-artery-risk-development-in-young-adults-cardia-study
#18
Reto Auer, Stephen Sidney, David Goff, Eric Vittinghoff, Mark J Pletcher, Norrina B Allen, Jared P Reis, Cora E Lewis, Jeffrey Carr, Jamal S Rana
BACKGROUND AND AIMS: Unlike tobacco, the effect of marijuana smoke on subclinical atherosclerosis, a surrogate measure for cardiovascular disease, is not known. This study aimed to determine the association between lifetime exposure to marijuana and measures of subclinical atherosclerosis in mid-life. DESIGN, SETTING AND PARTICIPANTS: We used data from the US-based Coronary Artery Risk Development in Young Adults (CARDIA) Study, a cohort of black and white men and women aged 18-30 years at baseline in 1985-86, with up to 7 follow-up exams over 25 years...
November 22, 2017: Addiction
https://www.readbyqxmd.com/read/29157464/characterization-of-coronary-plaque-regions-in-intravascular-ultrasound-images-using-a-hybrid-ensemble-classifier
#19
Yoo Na Hwang, Ju Hwan Lee, Ga Young Kim, Eun Seok Shin, Sung Min Kim
BACKGROUND AND OBJECTIVES: The purpose of this study was to propose a hybrid ensemble classifier to characterize coronary plaque regions in intravascular ultrasound (IVUS) images. METHODS: Pixels were allocated to one of four tissues (fibrous tissue (FT), fibro-fatty tissue (FFT), necrotic core (NC), and dense calcium (DC)) through processes of border segmentation, feature extraction, feature selection, and classification. Grayscale IVUS images and their corresponding virtual histology images were acquired from 11 patients with known or suspected coronary artery disease using 20 MHz catheter...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29155072/a-protocol-to-study-ex-vivo-mouse-working-heart-at-human-like-heart-rate
#20
Han-Zhong Feng, Jian-Ping Jin
Genetically modified mice are widely used as experimental models to study human heart function and diseases. However, the fast rate of normal mouse heart at 400-600bpm limits its capacity of assessing kinetic parameters that are important for the physiology and pathophysiology of human heart that beats at a much slower rate (75-180bpm). To extend the value of mouse models, we established a protocol to study ex vivo mouse working hearts at a human-like heart rate. In the presence of 300μM lidocaine to lower pacemaker and conductive activities and prevent arrhythmia, a stable rate of 120-130bpm at 37°C is achieved for ex vivo mouse working hearts...
November 16, 2017: Journal of Molecular and Cellular Cardiology
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