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https://www.readbyqxmd.com/read/29052965/from-vineyard-to-winery-a-source-map-of-microbial-diversity-driving-wine-fermentation
#1
Peter Morrison-Whittle, Matthew R Goddard
Humans have been making wine for thousands of years and microorganisms play an integral part in this process as they not only drive fermentation, but also significantly influence the flavour, aroma, and quality of finished wines. Since fruits are ephemeral, they cannot comprise a permanent microbial habitat; thus, an age-old unanswered question concerns the origin of fruit and ferment associated microbes. Here we use next-generation sequencing approaches to examine and quantify the roles of native forests, vineyard soil, bark, and fruit habitats as sources of fungal diversity in ferments...
October 20, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29049518/long-term-outcomes-after-proton-beam-irradiation-in-patients-with-large-choroidal-melanomas
#2
Thanos D Papakostas, Anne Marie Lane, Margaux Morrison, Evangelos S Gragoudas, Ivana K Kim
Importance: Although radiotherapy has been used more frequently in past decades for the management of large melanomas, long-term efficacy of proton beam irradiation (PBI) of large choroidal melanomas has not been reported. Objective: To evaluate long-term outcomes in patients who underwent PBI for the treatment of large choroidal melanomas. Design, Setting, and Participants: Data were obtained at a single Boston, Massachusetts, academic tertiary referral practice for this retrospective cohort study...
October 19, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29049426/are-surgical-residents-prepared-to-care-for-transgender-patients
#3
Shane D Morrison, Jesse R Smith, Samuel P Mandell
No abstract text is available yet for this article.
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29047425/legionnaires-disease-outbreak-caused-by-endemic-strain-of-legionella-pneumophila-new-york-new-york-usa-2015
#4
Pascal Lapierre, Elizabeth Nazarian, Yan Zhu, Danielle Wroblewski, Amy Saylors, Teresa Passaretti, Scott Hughes, Anthony Tran, Ying Lin, John Kornblum, Shatavia S Morrison, Jeffrey W Mercante, Robert Fitzhenry, Don Weiss, Brian H Raphael, Jay K Varma, Howard A Zucker, Jennifer L Rakeman, Kimberlee A Musser
During the summer of 2015, New York, New York, USA, had one of the largest and deadliest outbreaks of Legionnaires' disease in the history of the United States. A total of 138 cases and 16 deaths were linked to a single cooling tower in the South Bronx. Analysis of environmental samples and clinical isolates showed that sporadic cases of legionellosis before, during, and after the outbreak could be traced to a slowly evolving, single-ancestor strain. Detection of an ostensibly virulent Legionella strain endemic to the Bronx community suggests potential risk for future cases of legionellosis in the area...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29045471/parental-and-offspring-contribution-of-genetic-markers-of-adult-blood-pressure-in-early-life-the-family-study
#5
Sébastien Robiou-du-Pont, Sonia S Anand, Katherine M Morrison, Sarah D McDonald, Stephanie A Atkinson, Koon K Teo, David Meyre
Previous genome wide association studies (GWAS) identified associations of multiple common variants with diastolic and systolic blood pressure traits in adults. However, the contribution of these loci to variations of blood pressure in early life is unclear. We assessed the child and parental contributions of 33 GWAS single-nucleotide polymorphisms (SNPs) for blood pressure in 1,525 participants (515 children, 406 mothers and 237 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) study followed-up for 5 years...
2017: PloS One
https://www.readbyqxmd.com/read/29045349/male-specific-association-between-fat-free-mass-index-and-faecal-microbiota-in-2-to-3-year-old-australian-children
#6
Paula Smith-Brown, Mark Morrison, Lutz Krause, Peter S W Davies
OBJECTIVES: Maturation of the gut microbiota has been shown to influence childhood growth while alterations in microbiota composition are proposed to be causally related to the development of overweight and obesity. The objective of this study is to explore the association between microbiota profile, body size and body composition in young children. METHODS: Faecal microbiota was examined by 16S rRNA gene sequencing while body composition was assessed using the deuterium oxide dilution technique in a cohort of 37 well-nourished 2 to 3 year old Australian children...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29042611/developmental-stage-dependent-regulation-of-spine-formation-by-calcium-calmodulin-dependent-protein-kinase-ii%C3%AE-and-rap1
#7
Solveigh Cornelia Koeberle, Shinji Tanaka, Toshihiko Kuriu, Hirohide Iwasaki, Andreas Koeberle, Alexander Schulz, Dario-Lucas Helbing, Yoko Yamagata, Helen Morrison, Shigeo Okabe
The roles of calcium-calmodulin-dependent protein kinase II-alpha (CaMKIIα) in the expression of long-term synaptic plasticity in the adult brain have been extensively studied. However, how increased CaMKIIα activity controls the maturation of neuronal circuits remains incompletely understood. Herein, we show that pyramidal neurons without CaMKIIα activity upregulate the rate of spine addition, resulting in elevated spine density. Genetic elimination of CaMKIIα activity specifically eliminated the observed maturation-dependent suppression of spine formation...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29041982/costs-related-to-cardiac-arrest-management-a-systematic-review-protocol
#8
Guillaume Geri, Joshua Gilgan, Carolyn Ziegler, Wanrudee Isaranuwatchai, Laurie J Morrison
BACKGROUND: Each year, about 500,000 people suffer a cardiac arrest (either out-of-hospital or in-hospital) in the USA. Although significant improvements in survival have occurred through the implementation of complex high-quality protocols of care, global costs related to such management are not clearly described. METHODS: We will undertake a systematic review of the published literature on costs related to the acute phase of cardiac arrest management (from collapse to hospital discharge)...
October 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29041710/beam-shaping-with-tip-tilt-varifocal-mirror-for-indoor-optical-wireless-communication
#9
Corey Pollock, Jessica Morrison, Matthias Imboden, Thomas D C Little, D J Bishop
MEMS mirrors are currently used in many applications to steer beams of light. An area of continued research is developing mirrors with varifocal capability that allows the beam to be shaped and focused. In this work, we study the varifocal capability of a 380 μm diameter, thermally actuated MEMS mirror with a ± 40° tip-tilt angle and a radius of curvature between -0.48 mm to 20.5 mm. Light is coupled to the mirror via a single mode optical fiber, similar to an indoor optical wireless communication architecture...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29041313/lasing-in-ring-resonators-by-stimulated-brillouin-scattering-in-the-presence-of-nonlinear-loss
#10
Sayyed Reza Mirnaziry, Christian Wolff, M J Steel, Blair Morrison, Benjamin J Eggleton, Christopher G Poulton
We theoretically investigate lasing due to stimulated Brillouin scattering in integrated ring resonators. We give analytic expressions and numerical calculations for the lasing threshold for rings in the presence of for both linear and nonlinear loss. We demonstrate the operation of the ring in the different regimes of amplification and lasing, and show how these regimes depend on the coupling to the ring and on the nonlinear parameters. In the case of nonlinear losses, we find that there can exist an upper threshold to the lasing regime where the losses are dominated by free-carrier absorption...
October 2, 2017: Optics Express
https://www.readbyqxmd.com/read/29041068/relativistic-electron-acceleration-by-mj-class-khz-lasers-normally-incident-on-liquid-targets
#11
Scott Feister, Drake R Austin, John T Morrison, Kyle D Frische, Chris Orban, Gregory Ngirmang, Abraham Handler, Joseph R H Smith, Mark Schillaci, Jay A LaVerne, Enam A Chowdhury, R R Freeman, W M Roquemore
We report observation of kHz-pulsed-laser-accelerated electron energies up to 3 MeV in the -klaser (backward) direction from a 3 mJ laser interacting at normal incidence with a solid density, flowing-liquid target. The electrons/MeV/s.r. >1 MeV recorded here using a mJ-class laser exceeds or equals that of prior super-ponderomotive electron studies employing lasers at lower repetition-rates and oblique incidence. Focal intensity of the 40-fs-duration laser is 1.5 · 10(18) W cm(-2), corresponding to only ∼80 keV electron ponderomotive energy...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29040750/cool-callous-and-in-control-superior-inhibitory-control-in-frequent-players-of-video-games-with-violent-content
#12
Laura Stockdale, Robert G Morrison, Robert Palumbo, James Garbarino, Rebecca L Silton
Research on the effects of media violence exposure has shown robust associations among violent media exposure, increased aggressive behavior, and decreased empathy. Preliminary research indicates that frequent players of violent video games may have differences in emotional and cognitive processes compared to infrequent or non-players, yet research examining the amount and content of game play and the relation of these factors with affective and cognitive outcomes is limited. The present study measured neural correlates of response inhibition in the context of implicit attention to emotion, and how these factors are related to empathic responding in frequent and infrequent players of video games with graphically violent content...
October 4, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040612/er-stress-induced-aggresome-trafficking-of-htra1-protects-against-proteotoxicity
#13
Maximilian J Gerhardt, Joseph A Marsh, Margaux Morrison, Andrius Kazlauskas, Arogya Khadka, Stephan Rosenkranz, Margaret M DeAngelis, Magali Saint-Geniez, Sarah Melissa P Jacobo
No abstract text is available yet for this article.
October 13, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29040444/re-establishment-of-energy-balance-in-a-male-mouse-model-with-pomc-neuron-deletion-of-bmpr1a
#14
Kristy L Townsend, Christopher Madden, Magdalena Blaszkiewicz, Lindsay McDougall, Domenico Tupone, Matthew D Lynes, Yuji Mishina, Paul Yu, Shaun Morrison, Yu-Hua Tseng
The regulation of energy balance involves complex processes in the brain, including coordination by hypothalamic neurons that contain pro-opiomelanocortin (POMC). We previously demonstrated that central bone morphogenetic protein 7 (BMP7) reduces appetite. Now we show that a type 1 BMP receptor, BMPR1A, is co-localized with POMC neurons and POMC-BMPR1A-KO mice are hyperphagic, revealing physiological involvement of BMP signaling in anorectic POMC neurons in the regulation of appetite. Surprisingly, the hyperphagic POMC-BMPR1A-KO mice exhibit a lack of obesity, even on a 45% high-fat diet...
October 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/29039208/first-impressions-of-adults-with-autism-improve-with-diagnostic-disclosure-and-increased-autism-knowledge-of-peers
#15
Noah J Sasson, Kerrianne E Morrison
A practical consideration for many intellectually able adults with autism spectrum disorder (ASD) is whether to disclose their diagnostic status or try to mask their autistic characteristics to avoid judgment and discrimination. Here, we assessed first impressions of adults with ASD and typically developing controls ( N = 40) made by typically developing observers ( N = 215) when their diagnostic status was either withheld, accurately provided, or inaccurately provided. First impressions were less favorable for ASD participants compared to typically developing controls across a range of judgments, but were significantly more positive when accurately labeled as ASD compared to when no label was provided, when mislabeled as typically developing, or when mislabeled as having schizophrenia...
October 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29038483/quantitative-microglia-analyses-reveal-diverse-morphologic-responses-in-the-rat-cortex-after-diffuse-brain-injury
#16
Helena Morrison, Kimberly Young, Mahir Qureshi, Rachel K Rowe, Jonathan Lifshitz
Determining regions of altered brain physiology after diffuse brain injury is challenging. Microglia, brain immune cells with ramified and dynamically moving processes, constantly surveil the parenchyma for dysfunction which, when present, results in a changed morphology. Our purpose was to define the spatiotemporal changes in microglia morphology over 28 days following rat midline fluid percussion injury (mFPI) as a first step in exploiting microglia morphology to reflect altered brain physiology. Microglia morphology was quantified from histological sections using Image J skeleton and fractal analysis procedures at three time points and in three regions post-mFPI: impact site, primary somatosensory cortex barrel field (S1BF), and a remote region...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037798/electroencephalographic-assessment-of-oral-meloxicam-topical-anaesthetic-cream-and-cautery-iron-for-mitigating-acute-pain-in-pigs-sus-scrofa-undergoing-tail-docking
#17
Nikki J Kells, N J Beausoleil, M A Sutherland, R M Morrison, Craig B Johnson
OBJECTIVE: To evaluate the efficacy of oral meloxicam, topical anaesthetic cream and cautery iron in mitigating acute nociceptive responses of pigs to tail docking. STUDY DESIGN: A prospective, randomized, controlled experimental study. ANIMALS: A total of 40 healthy Large WhitexLandrace pigs aged 21±1 days, weighing 6.1±0.9 kg. METHODS: Pigs were randomly assigned to one of four treatments (n=10 per treatment): CONTROL: docked using clippers without analgesia; MEL: docked using clippers after administration of oral meloxicam; EMLA: docked using clippers after application of topical anaesthetic cream; and CAUT: docked using a cautery iron without analgesia...
February 24, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29036845/sexual-concerns-after-spinal-cord-injury-an-update-on-management
#18
Marcalee Sipski Alexander, Carrie Mlynarczyk Aisen, Sterling Morrison Alexander, Mindy Lipson Aisen
BACKGROUND: Spinal Cord Injury (SCI) causes neurological impairment with resultant neurogenic sexual dysfunction which can compound preexisting psychological and medical sexual concerns. Understanding these concerns is important in managing the lifelong needs of persons with SCIs. OBJECTIVES: To provide an overview of the impact of SCI on sexuality along with a framework for treatment of sexual concerns. To briefly review male infertility and its treatments and pregnancy in females after SCI...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29033149/management-of-cervicofacial-infections-a-survey-of-current-practice-in-maxillofacial-units-in-the-uk
#19
C McDonald, A Hennedige, A Henry, B Dawoud, R Kulkarni, K Gilbert, P Kyzas, R Morrison, J A McCaul
Cervicofacial infections are common emergency presentations to maxillofacial departments in the UK, there is no consensus about their management and, in particular, the role of corticosteroids is not clear. Our aim was to find out the current practice of UK maxillofacial surgeons in managing these infections using a multicentre questionnaire study. The questionnaire was designed, piloted, and revised before distribution, and questions were asked to assess preoperative, operative, and postoperative management...
October 12, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29032790/formative-qualitative-research-to-develop-community-based-interventions-addressing-low-birth-weight-in-the-plains-of-nepal
#20
Joanna Morrison, Sophiya Dulal, Helen Harris-Fry, Machhindra Basnet, Neha Sharma, Bhim Shrestha, Dharma Manandhar, Anthony Costello, David Osrin, Naomi Saville
OBJECTIVE: To explore the factors affecting intra-household food allocation practices to inform the development of interventions to prevent low birth weight in rural plains of Nepal. DESIGN: Qualitative methodology using purposive sampling to explore the barriers and facilitating factors to improved maternal nutrition. SETTING: Rural Dhanusha District, Nepal. SUBJECTS: We purposively sampled twenty-five young daughters-in-law from marginalised groups living in extended families and conducted semi-structured interviews with them...
October 16, 2017: Public Health Nutrition
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