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https://www.readbyqxmd.com/read/29668079/co-culture-of-adipose-derived-stem-cells-and-chondrocytes-on-three-dimensionally-printed-bioscaffolds-for-craniofacial-cartilage-engineering
#1
Robert J Morrison, Hassan B Nasser, Khaled N Kashlan, David A Zopf, Derek J Milner, Colleen L Flanangan, Matthew B Wheeler, Glenn E Green, Scott J Hollister
OBJECTIVES/HYPOTHESIS: Reconstruction of craniofacial cartilagenous defects are among the most challenging surgical procedures in facial plastic surgery. Bioengineered craniofacial cartilage holds immense potential to surpass current reconstructive options, but limitations to clinical translation exist. We endeavored to determine the viability of utilizing adipose-derived stem cell-chondrocyte co-culture and three-dimensional (3D) printing to produce 3D bioscaffolds for cartilage tissue engineering...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29667718/trajectories-of-psychopathology-in-extremely-low-birth-weight-survivors-from-early-adolescence-to-adulthood-a-20-year-longitudinal-study
#2
Ryan J Van Lieshout, Mark A Ferro, Louis A Schmidt, Michael H Boyle, Saroj Saigal, Katherine M Morrison, Karen J Mathewson
BACKGROUND: Individuals born extremely preterm are exposed to significant perinatal stresses that are associated with an increased risk of psychopathology. However, a paucity of longitudinal studies has prevented the empirical examination of long-term, dynamic effects of perinatal adversity on mental health. Here, internalizing and externalizing problems from adolescence through adulthood were compared in individuals born at extremely low birth weight (ELBW; <1,000 g) and normal birth weight (NBW; >2,500 g)...
April 18, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29666124/generation-of-a-double-binary-transgenic-zebrafish-model-to-study-myeloid-gene-regulation-in-response-to-oncogene-activation-in-melanocytes
#3
Amy Kenyon, Daria Gavriouchkina, Jernej Zorman, Vanessa Chong-Morrison, Giorgio Napolitani, Vincenzo Cerundolo, Tatjana Sauka-Spengler
A complex network of inflammatory genes is closely linked to somatic cell transformation and malignant disease. Immune cells and their associated molecules are responsible for detecting and eliminating cancer cells as they establish themselves as the precursors of a tumour. By the time a patient has a detectable solid tumour, cancer cells have escaped the initial immune response mechanisms. Here, we describe the development of a double binary zebrafish model that enables regulatory programming of the myeloid cells as they respond to oncogene-activated melanocytes to be explored, focussing on the initial phase when cells become the precursors of cancer...
April 6, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29665847/tensions-in-ethics-and-policy-created-by-national-precision-medicine-programs
#4
Jusaku Minari, Kyle B Brothers, Michael Morrison
Precision medicine promises to use genomics and other data-intensive approaches to improve diagnosis and develop new treatments for major diseases, but also raises a range of ethical and governance challenges. Implementation of precision medicine in "real world" healthcare systems blurs the boundary between research and care. This has implications for the meaning and validity of consent, and increased potential for discrimination, among other challenges. Increased sharing of personal information raises concerns about privacy, commercialization, and public trust...
April 17, 2018: Human Genomics
https://www.readbyqxmd.com/read/29665179/pseudoscience-snake-oil-and-indoor-air-quality
#5
EDITORIAL
Glenn Morrison
No abstract text is available yet for this article.
May 2018: Indoor Air
https://www.readbyqxmd.com/read/29665109/improving-the-performance-time-and-accuracy-of-ultrasound-guided-interventions-a-randomized-controlled-double-blind-trial-of-the-line-of-sight-approach-and-the-apples-mnemonic
#6
John W Norbury, Natalie C Karr, Vivek Sindhi, Kimberly M Rathbun, Stephen C Charles, Michael B McIver, Eric J Morrison
OBJECTIVES: To determine whether the line-of-sight approach improved the performance time and accuracy of ultrasound (US)-guided needle placement targeting the subdeltoid bursa in a cadaver among novice operators compared to the side approach. A secondary objective was to determine whether participants thought the APPLES (angle, position, perpendicular, line up, entry, sweep) mnemonic was a helpful guide for performing the procedure. METHODS: Medical students and residents were randomized into either a line-of-sight or side approach group and then crossed over to the other group...
April 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29661932/-chlamydia-muridarum-genital-and-gastrointestinal-infection-tropism-is-mediated-by-distinct-chromosomal-factors
#7
Sandra G Morrison, Amanda M Giebel, Evelyn C Toh, Horace J Spencer, David E Nelson, Richard P Morrison
Some members of the genus Chlamydia , including the human pathogen Chlamydia trachomatis , infect multiple tissues including the genital and gastrointestinal (GI) tracts. However, it is unknown if bacterial targeting to these sites is mediated by multifunctional or distinct chlamydial factors. We previously showed that disruption of individual large clostridial toxin homologs encoded within the Chlamydia muridarum plasticity zone were not critical for murine genital tract infection. Here, we assessed if cytotoxin genes contribute to C...
April 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29661925/changing-antiepilepsy-drug-prescribing-trends-in-women-with-epilepsy-in-the-uk-and-ireland-and-the-impact-on-major-congenital-malformations
#8
Michael O Kinney, James Morrow, Chris C Patterson, Ellen Campbell, Aline Russell, Henry W Smithson, Linda Parsons, Patrick J Morrison, Rebecca Bromley, Brenda Liggan, Norman Delanty, Beth Irwin, Stephen J Hunt, John J Craig
OBJECTIVES: After 20 years of data collection, pregnancy registers have informed prescribing practice. Various populations show trends for a reduction in valproate prescribing, which is associated with an increased risk of anatomical teratogenesis and neurodevelopmental effects in those exposed in utero. Our aim was to determine if any shifts in prescribing trends have occurred in the UK and Ireland Epilepsy and Pregnancy Register cohort and to assess if there had been any change in the overall major congenital malformation (MCM) rate over time...
April 16, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29661524/expressed-emotion-as-a-predictor-of-the-first-psychotic-episode-results-of-the-european-prediction-of-psychosis-study
#9
Theresa Haidl, Marlene Rosen, Frauke Schultze-Lutter, Dorien Nieman, Susanne Eggers, Markus Heinimaa, Georg Juckel, Andreas Heinz, Anthony Morrison, Don Linszen, Raimo Salokangas, Joachim Klosterkötter, Max Birchwood, Paul Patterson, Stephan Ruhrmann
OBJECTIVE: To investigate the impact of expressed emotion (EE) on the risk of developing the first psychotic episode (FEP). METHOD: The European Prediction of Psychosis Study (EPOS) investigated 245 patients who were at clinical high risk (CHR) of psychosis. The predictive value of EE alone and as a part of the multivariate EPOS model was evaluated. RESULTS: "Perceived irritability", a domain of the Level of Expressed Emotion Scale (LEE), was found to be predictive for the First Psychotic Episode (FEP), even as an individual variable...
April 13, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29661286/comparison-of-zone-3-resuscitative-endovascular-balloon-occlusion-of-the-aorta-and-the-abdominal-aortic-and-junctional-tourniquet-in-a-model-of-junctional-hemorrhage-in-swine
#10
Jason M Rall, Theodore T Redman, Elliot M Ross, Jonathan J Morrison, Joseph K Maddry
BACKGROUND: Traumatic injuries to the pelvis and high junctional injuries are difficult to treat in the field; however, Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) and the Abdominal Aortic and Junctional Tourniquet (AAJT) constitute two promising treatment modalities. The aim of this study is to use a large animal model of pelvic hemorrhage to compare the survival, hemostatic, hemodynamic, and metabolic profile of both techniques. METHODS: Yorkshire swine (n = 10, 70-90 kg) underwent general anesthesia, instrumentation, and surgical isolation of the femoral artery...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660966/community-based-interventions-for-adolescents-following-traumatic-brain-injury-a-systematic-review
#11
Betony Clasby, Nathan Hughes, Cathy Catroppa, Elle Morrison
BACKGROUND: Chronic impairment following childhood traumatic brain injury has the potential to increase risk of negative outcomes. This highlights potential value of community-based rehabilitation programs. OBJECTIVES: To identify research studies examining existing intervention programmes available in community-based rehabilitation to adolescents following TBI to assist with the transition back into the community. METHODS: A systematic review of community-based interventions was conducted across different national contexts...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660039/trial-readiness-in-cavernous-angiomas-with-symptomatic-hemorrhage-cash
#12
Sean P Polster, Ying Cao, Timothy Carroll, Kelly Flemming, Romuald Girard, Daniel Hanley, Nicholas Hobson, Helen Kim, James Koenig, Janne Koskimäki, Karen Lane, Jennifer J Majersik, Nichol McBee, Leslie Morrison, Robert Shenkar, Agnieszka Stadnik, Richard E Thompson, Joseph Zabramski, Hussein A Zeineddine, Issam A Awad
BACKGROUND: Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require testing of safety and efficacy in multisite clinical trials. Much progress has been made in understanding the epidemiology of CASH, and novel biomarkers have been linked to the biological mechanisms and clinical activity in lesions...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29657460/a-quality-improvement-project-decreases-incidence-of-pulmonary-embolism-following-arthroplasty
#13
Iyad Eid, Dane Moran, Lynn Morrison, Eyad HajHussein, Hanna Hill, Rasha Ansari, Tammy Williams, Mojieb Manzary
Objective: To develop a quality improvement initiative to reduce the incidence of pulmonary embolism (PE) following elective lower extremity joint replacement surgery. Methods: 866 Patients undergoing a total knee or total or partial hip replacement surgery at a from 2014 to 2016 were included in this prospective pre-post interventional study. Results: There were 13 PE's before the intervention and 2 after the intervention. The incidence of PE was significantly higher prior to the intervention (2...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656578/long-term-single-center-comparison-of-icd-lead-survival-evidence-for-premature-linox-lead-failure
#14
Matthew O'Connor, Darren Hooks, Matthew Webber, Bijia Shi, Stephanie Morrison, Scott Harding, Peter Larsen
INTRODUCTION: ICD lead failure is a potential source of significant morbidity and mortality. This study investigates the survival rates of Sprint Quattro, Endotak Reliance and Linox ICD leads. METHODS AND RESULTS: A retrospective cohort study of all patients with an ICD implanted between January 2007 and December 2012 from the Wellington Hospital region, New Zealand, a tertiary referral center. Lead and patient details were established by review of clinical notes and the PaceArt Optima database...
April 14, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29655632/ag85a-specific-cd4-t-cell-lines-derived-after-boosting-bcg-vaccinated-cattle-with-ad5-85a-possess-both-mycobacterial-growth-inhibition-and-anti-inflammatory-properties
#15
Hannah J Metcalfe, Lucia Biffar, Sabine Steinbach, Efrain Guzman, Tim Connelley, Ivan Morrison, H Martin Vordermeier, Bernardo Villarreal-Ramos
There is a need to improve the efficacy of the BCG vaccine against human and bovine tuberculosis. Previous data showed that boosting bacilli Calmette-Guerin (BCG)-vaccinated cattle with a recombinant attenuated human type 5 adenovirally vectored subunit vaccine (Ad5-85A) increased BCG protection and was associated with increased frequency of Ag85A-specific CD4+ T cells post-boosting. Here, the capacity of Ag85A-specific CD4+ T cell lines - derived before and after viral boosting - to interact with BCG-infected macrophages was evaluated...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29650966/understanding-the-adsorption-process-in-zif-8-using-high-pressure-crystallography-and-computational-modelling
#16
Claire L Hobday, Christopher H Woodall, Matthew J Lennox, Mungo Frost, Konstantin Kamenev, Tina Düren, Carole A Morrison, Stephen A Moggach
Some porous crystalline solids change their structure upon guest inclusion. Unlocking the potential of these solids for a wide variety of applications requires full characterisation of the response to adsorption and the underlying framework-guest interactions. Here, we introduce an approach to understanding gas uptake in porous metal-organic frameworks (MOFs) by loading liquefied gases at GPa pressures inside the Zn-based framework ZIF-8. An integrated experimental and computational study using high-pressure crystallography, grand canonical Monte Carlo (GCMC) and periodic DFT simulations has revealed six symmetry-independent adsorption sites within the framework and a transition to a high-pressure phase...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29648537/the-conformation-of-the-histone-h3-tail-inhibits-association-of-the-bptf-phd-finger-with-the-nucleosome
#17
Emma A Morrison, Samuel Bowerman, Kelli L Sylvers, Jeff Wereszczynski, Catherine A Musselman
Histone tails harbor a plethora of post-translational modifications that direct the function of chromatin regulators, which recognize them through effector domains. Effector domain/histone interactions have been broadly studied, but largely using peptide fragments of histone tails. Here, we extend these studies into the nucleosome context and find that the conformation adopted by the histone H3 tails is inhibitory to BPTF PHD finger binding. Using NMR spectroscopy and MD simulations, we show that the H3 tails interact robustly but dynamically with nucleosomal DNA, substantially reducing PHD finger association...
April 12, 2018: ELife
https://www.readbyqxmd.com/read/29644094/insufficiency-of-dna-repair-enzyme-atm-promotes-naive-cd4-t-cell-loss-in-chronic-hepatitis-c-virus-infection
#18
Juan Zhao, Xindi Dang, Peixin Zhang, Lam Nhat Nguyen, Dechao Cao, Lin Wang, Xiaoyuan Wu, Zheng D Morrison, Ying Zhang, Zhansheng Jia, Qian Xie, Ling Wang, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao
T cells have a crucial role in viral clearance and vaccine response; however, the mechanisms regulating their responses to viral infections or vaccinations remain elusive. In this study, we investigated T-cell homeostasis, apoptosis, DNA damage, and repair machineries in a large cohort of subjects with hepatitis C virus (HCV) infection. We found that naive CD4 T cells in chronically HCV-infected individuals (HCV T cells) were significantly reduced compared with age-matched healthy subjects. In addition, HCV T cells were prone to apoptosis and DNA damage, as evidenced by increased 8-oxoguanine expression and γH2AX/53BP1-formed DNA damage foci-hallmarks of DNA damage responses...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29642744/evaluation-of-continuous-infusion-vancomycin-administration-in-a-critically-ill-trauma-population
#19
Brittany D Bissell, Gina Riggi, Christopher Morrison
Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection and drug monitoring. The objective of this study was to evaluate time to goal vancomycin levels comparing a continuous infusion protocol when compared to standard intermittent infusion dosing. This was a retrospective cohort of patients admitted to the trauma intensive care unit between July 2011 and July 2015 receiving vancomycin for at least 48 hours...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29630021/changing-patterns-and-factors-associated-with-mode-of-delivery-among-pregnant-women-with-human-immunodeficiency-virus-infection-in-the-united-states
#20
Kartik K Venkatesh, Leavitt Morrison, Elizabeth G Livingston, Alice Stek, Jennifer S Read, David E Shapiro, Ruth E Tuomala
OBJECTIVE: To describe patterns and factors associated with mode of delivery among pregnant women with human immunodeficiency virus (HIV) infection in the United States in relation to evolving HIV-in-pregnancy guidelines. METHODS: We conducted an analysis of two observational studies, Pediatric AIDS Clinical Trials Group and International Maternal Pediatric Adolescent AIDS Clinical Trials Network Protocol P1025, which enrolled pregnant women with HIV infection from 1998 to 2013 at more than 60 U...
April 6, 2018: Obstetrics and Gynecology
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