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https://www.readbyqxmd.com/read/28830117/analysis-of-dextromethorphan-and-dextrorphan-in-skeletal-remains-following-differential-microclimate-exposure-comparison-of-acute-vs-repeated-drug-exposure
#1
Lucas M Morrison, Kirk A Unger, James H Watterson
Analysis of dextromethorphan (DXM) and its metabolite dextrorphan (DXT) in skeletal remains of rats following acute (ACU, 75 mg/kg, IP, n = 10) or three repeated (REP, 25 mg/kg, IP, n = 10, 40-min interval) doses of DXM is described. Following dosing and euthanasia, rats decomposed outdoors to skeleton in two different microclimate environments (n = 5 ACU and n = 5 REP at each site): Site A (shaded forest microenvironment) and Site B (rocky substrate exposed to direct sunlight, 600 m from Site A). Two drug-free rats at each site served as negative controls...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28829273/postracial-fantasies-and-the-reproduction-of-scientific-racism
#2
Patrick Ryan Grzanka, Daniel R Morrison
No abstract text is available yet for this article.
September 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28822682/a-systematic-review-of-digital-interventions-for-improving-the-diet-and-physical-activity-behaviors-of-adolescents
#3
REVIEW
Taylor Rose, Mary Barker, Chandni Maria Jacob, Leanne Morrison, Wendy Lawrence, Sofia Strömmer, Christina Vogel, Kathryn Woods-Townsend, David Farrell, Hazel Inskip, Janis Baird
Many adolescents have poor diet and physical activity behaviors, which can lead to the development of noncommunicable diseases in later life. Digital platforms offer inexpensive means of delivering health interventions, but little is known about their effectiveness. This systematic review was conducted to synthesize evidence on the effectiveness of digital interventions to improve diet quality and increase physical activity in adolescents, to effective intervention components and to assess the cost-effectiveness of these interventions...
August 16, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28821547/cultivation-in-space-flight-produces-minimal-alterations-in-the-susceptibility-of-bacillus-subtilis-cells-to-72-different-antibiotics-and-growth-inhibiting-compounds
#4
Michael D Morrison, Patricia Fajardo-Cavazos, Wayne L Nicholson
Past results have suggested that bacterial antibiotic susceptibility is altered during space flight. To test this notion, Bacillus subtilis cells were cultivated in matched hardware, medium, and environmental conditions either in spaceflight microgravity on the International Space Station, termed Flight (FL) samples, or at Earth-normal gravity, termed Ground Control (GC) samples. Susceptibility of FL and GC samples was compared to 72 antibiotics and growth-inhibitory compounds using the Omnilog Phenotype Microarray (PM) system...
August 18, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28819242/the-saliva-microbiome-profiles-are-minimally-affected-by-collection-method-or-dna-extraction-protocols
#5
Yenkai Lim, Makrina Totsika, Mark Morrison, Chamindie Punyadeera
Saliva has attracted attention as a diagnostic fluid due to the association of oral microbiota with systemic diseases. However, the lack of standardised methods for saliva collection has led to the slow uptake of saliva in microbiome research. The aim of this study was to systematically evaluate the potential effects on salivary microbiome profiles using different methods of saliva collection, storage and gDNA extraction. Three types of saliva fractions were collected from healthy individuals with or without the gDNA stabilising buffer...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818812/airborne-ultrafine-particles-in-a-pacific-island-country-characteristics-sources-and-implications-for-human-exposure
#6
C F Isley, P F Nelson, M P Taylor, M Mazaheri, L Morawska, A J Atanacio, E Stelcer, D D Cohen, Anthony L Morrison
The Pacific Islands carry a perception of having clean air, yet emissions from transport and burning activities are of concern in regard to air quality and health. Ultrafine particle number concentrations (PNCs), one of the best metrics to demonstrate combustion emissions, have not been measured either in Suva or elsewhere in the Islands. This work provides insight into PNC variation across Suva and its relationship with particle mass (PM) concentration and composition. Measurements over a short monitoring campaign provide a vignette of conditions in Suva...
August 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28817507/comparison-of-consent-models-in-a-randomized-trial-of-corticosteroids-in-pediatric-septic-shock
#7
Kusum Menon, Katharine O'Hearn, James Dayre McNally, Anand Acharya, Hector R Wong, Margaret Lawson, Tim Ramsay, Lauralyn McIntyre, Elaine Gilfoyle, Marisa Tucci, David Wensley, Ronald Gottesman, Gavin Morrison, Karen Choong
OBJECTIVES: To describe the use of deferred and prior informed consent models in the context of a low additional risk to standard of care, placebo-controlled randomized controlled trial of corticosteroids in pediatric septic shock. DESIGN: An observational substudy of consent processes in a randomized controlled trial of hydrocortisone versus placebo. SETTING: Seven tertiary level PICUs in Canada. PATIENTS: Children newborn to 17 years inclusive admitted to PICU with suspected septic shock between July 2014 and March 2016...
August 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28817376/association-between-hospice-spending-on-patient-care-and-rates-of-hospitalization-and-medicare-expenditures-of-hospice-enrollees
#8
Melissa D Aldridge, Andrew J Epstein, Abraham A Brody, Eric J Lee, R Sean Morrison, Elizabeth H Bradley
BACKGROUND: Care at the end of life is increasingly fragmented and is characterized by multiple hospitalizations, even among patients enrolled with hospice. OBJECTIVE: To determine whether hospice spending on direct patient care (including the cost of home visits, drugs, equipment, and counseling) is associated with hospital utilization and Medicare expenditures of hospice enrollees. DESIGN: Longitudinal, observational cohort study (2008-2010)...
August 17, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28815668/primary-low-grade-neuroendocrine-carcinoma-of-the-skin-an-exceedingly-rare-entity
#9
Tiffany Y Chen, Annie O Morrison, Joe Susa, Clay J Cockerell
Low-grade neuroendocrine tumors (NET), also known as carcinoid tumor, commonly arise from the gastrointestinal and pulmonary tracts, but rarely occur in the skin. Cutaneous NET typically occurs as metastases or high grade primary lesions, called Merkel cell carcinoma. In the few cases described in literature, primary low-grade neuroendocrine carcinomas of the skin (LGNECS) are usually indolent cutaneous nodules, presenting on the head and trunk of elderly patients. LGNECS tumors are histologically similar to its counterparts arising in other anatomic locations...
August 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28814448/carcinogen-susceptibility-is-regulated-by-genome-architecture-and-predicts-cancer-mutagenesis
#10
Pablo E García-Nieto, Erin K Schwartz, Devin A King, Jonas Paulsen, Philippe Collas, Rafael E Herrera, Ashby J Morrison
The development of many sporadic cancers is directly initiated by carcinogen exposure. Carcinogens induce malignancies by creating DNA lesions (i.e., adducts) that can result in mutations if left unrepaired. Despite this knowledge, there has been remarkably little investigation into the regulation of susceptibility to acquire DNA lesions. In this study, we present the first quantitative human genome-wide map of DNA lesions induced by ultraviolet (UV) radiation, the ubiquitous carcinogen in sunlight that causes skin cancer...
August 16, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28811502/sex-steroid-hormones-regulate-leptin-transcript-accumulation-and-protein-secretion-in-3t3-l1-cells
#11
Mónica Z Jenks, Heather E Fairfield, Erik C Johnson, Ron F Morrison, Gloria K Muday
Leptin is an adipokine produced by fat cells that regulates food consumption and metabolic activity. Sexual dimorphism in leptin and fat stores have been observed in humans and rodents with females having more leptin and greater levels of subcutaneous fat than males. One potential mechanism leading to this dimorphism is steroid hormone regulated synthesis of transcripts encoding leptin. Identification of direct regulatory mechanisms is difficult in animals or primary adipocytes due to these intertwined dimorphisms...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811495/low-protein-induced-increases-in-fgf21-drive-ucp1-dependent-metabolic-but-not-thermoregulatory-endpoints
#12
Cristal M Hill, Thomas Laeger, Diana C Albarado, David H McDougal, Hans-Rudolf Berthoud, Heike Münzberg, Christopher D Morrison
Dietary protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food intake, and these effects require the metabolic hormone fibroblast growth factor 21 (FGF21). Here we test whether the induction of energy expenditure during protein restriction requires UCP1, promotes a resistance to cold stress, and is dependent on the concomitant hyperphagia. Wildtype, Ucp1-KO and Fgf21-KO mice were placed on control and low protein (LP) diets to assess changes in energy expenditure, food intake and other metabolic endpoints...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811280/dan-nbl1-promotes-collective-neural-crest-migration-by-restraining-uncontrolled-invasion
#13
Rebecca McLennan, Caleb M Bailey, Linus J Schumacher, Jessica M Teddy, Jason A Morrison, Jennifer C Kasemeier-Kulesa, Lauren A Wolfe, Madeline M Gogol, Ruth E Baker, Philip K Maini, Paul M Kulesa
Neural crest cells are both highly migratory and significant to vertebrate organogenesis. However, the signals that regulate neural crest cell migration remain unclear. In this study, we test the function of differential screening-selected gene aberrant in neuroblastoma (DAN), a bone morphogenetic protein (BMP) antagonist we detected by analysis of the chick cranial mesoderm. Our analysis shows that, before neural crest cell exit from the hindbrain, DAN is expressed in the mesoderm, and then it becomes absent along cell migratory pathways...
August 15, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28810418/preventing-cardiovascular-disease-participant-perspectives-of-the-faith-program
#14
LaPrincess C Brewer, Eleshia J Morrison, Joyce E Balls-Berry, Patrick Dean, Kandace Lackore, Sarah Jenkins, Consuelo Cohen, Jacqueline Johnson, Frances Ellis, D C Mangum, Sharonne N Hayes, Christi Patten
Striking cardiovascular health disparities exist among African-Americans in Minnesota compared to Whites; however, community-based interventions to address cardiovascular disease risk are lacking. This study explored participant perceptions of a culturally tailored, cardiovascular disease prevention program developed using a community-based participatory research process. Research participation perceptions, program benefits, and program satisfaction/acceptability were analyzed using a mixed-methods approach...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28809645/screening-for-functional-cognition-in-postacute-care-and-the-improving-medicare-post-acute-care-transformation-impact-act-of-2014
#15
Gordon Muir Giles, Dorothy Farrar Edwards, M Tracy Morrison, Carolyn Baum, Timothy J Wolf
Occupational therapists have a long history of assessing functional cognition, defined as the ability to use and integrate thinking and performance skills to accomplish complex everyday activities. In response to passage of the Improving Medicare Post-Acute Care Transformation (IMPACT) Act of 2014 (Pub. L. 113-185), the American Occupational Therapy Association has been advocating that the Centers for Medicare and Medicaid Services consider functional cognition for inclusion in routine patient assessment in postacute care settings, with important implications for occupational therapy...
September 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28806994/patterns-of-locoregional-failure-following-post-operative-intensity-modulated-radiotherapy-to-oral-cavity-cancer-quantitative-spatial-and-dosimetric-analysis-using-a-deformable-image-registration-workflow
#16
Abdallah S R Mohamed, Andrew J Wong, Clifton D Fuller, Mona Kamal, Gary B Gunn, Jack Phan, William H Morrison, Beth M Beadle, Heath Skinner, Stephen Y Lai, Sean R Quinlan-Davidson, Abdelaziz M Belal, Ahmed G El-Gowily, Steven J Frank, David I Rosenthal, Adam S Garden
BACKGROUND: We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT). METHODS: Two hundred eighty-nine OCC patients receiving PO-IMRT were retrospectively reviewed from 2000 to 2012. Diagnostic CT documenting recurrence (rCT) was co-registered with planning CT (pCT) using a validated deformable image registration software. Manually segmented recurrent gross disease (rGTV) was deformed to co-registered pCTs...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28805949/the-reversible-p2y12-antagonist-act-246475-causes-significantly-less-blood-loss-than-ticagrelor-at-equivalent-antithrombotic-efficacy-in-rat
#17
Markus Rey, Markus Kramberg, Patrick Hess, Keith Morrison, Roland Ernst, Franck Haag, Edgar Weber, Martine Clozel, Martine Baumann, Eva Caroff, Francis Hubler, Markus A Riederer, Beat Steiner
The P2Y12 receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting, reversible P2Y12 antagonists, ACT-246475 and ticagrelor, in a rat thrombosis model by simultaneous quantification of their antithrombotic efficacy and surgery-induced blood loss. Blood flow velocity was assessed in the carotid artery after FeCl3 -induced thrombus formation using a Doppler flow probe. At the same time, blood loss after surgical wounding of the spleen was quantified...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28803848/disengagement-in-immigrant-groups-receiving-services-for-a-first-episode-of-psychosis
#18
Anika Maraj, Franz Veru, Laura Morrison, Ridha Joober, Ashok Malla, Srividya Iyer, Jai Shah
OBJECTIVE: Although early intervention (EI) programs for psychosis invest in clients remaining engaged in treatment, disengagement remains a concern. It is not entirely clear whether immigrants are likelier to disengage. The rates and predictors of disengagement for immigrant vis-à-vis non-immigrant clients in a Canadian EI setting were analyzed. METHOD: 297 clients were included in a time-to-event analysis with Cox Proportional Hazards regression models. Immigrant status (first- or second-generation immigrant or non-immigrant), age, gender, education, substance abuse, family contact, social and material deprivation and medication non-adherence were tested as predictors of service disengagement...
August 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28801841/the-use-of-aortic-balloon-occlusion-in-traumatic-shock-first-report-from-the-abo-trauma-registry
#19
M Sadeghi, K F Nilsson, T Larzon, A Pirouzram, A Toivola, P Skoog, K Idoguchi, Y Kon, T Ishida, Y Matsumara, J Matsumoto, V Reva, M Maszkowski, A Bersztel, E Caragounis, M Falkenberg, L Handolin, B Kessel, D Hebron, F Coccolini, L Ansaloni, J J Morrison, T M Hörer, M J Madurska
PURPOSE: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technique for temporary stabilization of patients with non-compressible torso hemorrhage. This technique has been increasingly used worldwide during the past decade. Despite the good outcomes of translational studies, clinical studies are divided. The aim of this multicenter-international study was to capture REBOA-specific data and outcomes. METHODS: REBOA practicing centers were invited to join this online register, which was established in September 2014...
August 11, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28800747/bovine-cryptosporidiosis-impact-host-parasite-interaction-and-control-strategies
#20
REVIEW
Sarah Thomson, Carly A Hamilton, Jayne C Hope, Frank Katzer, Neil A Mabbott, Liam J Morrison, Elisabeth A Innes
Gastrointestinal disease caused by the apicomplexan parasite Cryptosporidium parvum is one of the most important diseases of young ruminant livestock, particularly neonatal calves. Infected animals may suffer from profuse watery diarrhoea, dehydration and in severe cases death can occur. At present, effective therapeutic and preventative measures are not available and a better understanding of the host-pathogen interactions is required. Cryptosporidium parvum is also an important zoonotic pathogen causing severe disease in people, with young children being particularly vulnerable...
August 11, 2017: Veterinary Research
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