keyword
MENU ▼
Read by QxMD icon Read
search

Single muscle fiber

keyword
https://www.readbyqxmd.com/read/29625438/changes-in-myosin-heavy-chain-isoforms-along-the-length-of-orbital-fibers-in-rabbit-extraocular-muscle
#1
Christine A Lucas, Hannah S M Rhee, Joseph F Y Hoh
Purpose: Extraocular muscles express 10 myosin heavy chain (MyHC) isoforms that cater for a wide range of contractile speeds. We aim to characterize the variations in MyHC expression along the length of singly (SIFs) and multiply innervated fibers (MIFs) in the orbital layer of rabbit superior rectus muscle. Methods: Monospecific antibodies to nine MyHCs, including an anti-slow-tonic antibody characterized here were used to immunohistochemically map variations in MyHC distribution in serial sections along the muscle's full length...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29607567/shear-strain-rate-from-phase-contrast-velocity-encoded-mri-application-to-study-effects-of-aging-in-the-medial-gastrocnemius-muscle
#2
Usha Sinha, Vadim Malis, Robert Csapo, Marco Narici, Shantanu Sinha
BACKGROUND: Strain rate (SR) is a measure of the rate of regional deformation that can be computed by analyzing velocity-encoded phase-contrast 2D images. Recent studies have explored the changes in normal components of the strain tensor in aging muscle, while shear strain may also provide valuable information. PURPOSE: To compute the shear SR from velocity-encoded MRI of the lower leg and to study the correlation of SR parameters measured in the medial gastrocnemius (MG) to muscle force in a cohort of young and senior subjects...
April 1, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29595913/past-injurious-exercise-attenuates-activation-of-primary-calcium-dependent-injury-pathways-in-skeletal-muscle-during-subsequent-exercise
#3
Ryo Takagi, Riki Ogasawara, Junya Takegaki, Yuki Tamura, Arata Tsutaki, Koichi Nakazato, Naokata Ishii
Past contraction-induced skeletal muscle injury reduces the degree of subsequent injury; this phenomenon is called the "repeated bout effect (RBE)." This study addresses the mechanisms underlying the RBE, focusing on primary calcium-dependent injury pathways. Wistar rats were subdivided into single injury (SI) and repeated injury (RI) groups. At age 10 weeks, the right gastrocnemius muscle in each rat in the RI group was subjected to strenuous eccentric contractions (ECs). Subsequently, mild ECs were imposed on the same muscle of each rat at 14 weeks of age in both groups...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29570537/myocellular-responses-to-concurrent-flywheel-training-during-70-days-of-bed-rest
#4
Kevin A Murach, Kiril Minchev, Greg J Grosicki, Kaleen Lavin, Ryan K Perkins, Jeffrey W Ryder, Jessica Scott, Lori Ploutz-Snyder, Todd A Trappe, Scott Trappe
PURPOSE: This investigation evaluated myocellular responses to an integrated resistance and aerobic training program (SPRINT) during 70 days of bed rest. METHODS: Training was six days per week on a small-footprint gravity-independent flywheel resistance and aerobic device (FLY); three days of maximal flywheel supine quadriceps and calf exercises with continuous rowing separated by 4-6 hours, and three days of interval rowing. Vastus lateralis (VL) and soleus (SOL) muscle biopsies were obtained from eight healthy males (age=28±4 y, BMI=25±3 kg•m, VO2max=42±6 ml•kg•min) before and after 6° head-intrdown tilt bed rest...
March 22, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29568271/end-of-fiber-signals-strongly-influence-the-first-and-second-phases-of-the-m-wave-in-the-vastus-lateralis-implications-for-the-study-of-muscle-excitability
#5
Javier Rodriguez-Falces, Nicolas Place
It has been recurrently observed that, for compound muscle action potentials (M wave) recorded over the innervation zone of the vastus lateralis , the descending portion of the first phase generally shows an "inflection" or "shoulder." We sought to clarify the electrical origin of this shoulder-like feature and examine its implications. M waves evoked by maximal single shocks to the femoral nerve were recorded in monopolar and bipolar configurations from 126 individuals using classical (10-mm recording diameter, 20-mm inter-electrode distance) electrodes and from eight individuals using small electrodes arranged in a linear array...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29559302/myo-nog-cells-are-present-in-the-ciliary-processes-on-the-zonule-of-zinn-and-posterior-capsule-of-the-lens-following-cataract-surgery
#6
Jacquelyn Gerhart, Colleen Withers, Colby Gerhart, Liliana Werner, Nick Mamalis, Arturo Bravo-Nuevo, Victoria Scheinfeld, Paul FitzGerald, Robert Getts, Mindy George-Weinstein
Myo/Nog cells, named for their expression of MyoD and noggin, enter the eye during early stages of embryonic development. Their release of noggin is critical for normal morphogenesis of the lens and retina. Myo/Nog cells are also present in adult eyes. Single nucleated skeletal muscle cells designated as myofibroblasts arise from Myo/Nog cells in cultures of lens tissue. In this report we document the presence of Myo/Nog cells in the lens, ciliary body and on the zonule of Zinn in mice, rabbits and humans. Myo/Nog cells were rare in all three structures...
March 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29554873/mapping-qtl-for-white-striping-in-relation-to-breast-muscle-yield-and-meat-quality-traits-in-broiler-chickens
#7
Eva Pampouille, Cécile Berri, Simon Boitard, Christelle Hennequet-Antier, Stéphane A Beauclercq, Estelle Godet, Christophe Praud, Yves Jégo, Elisabeth Le Bihan-Duval
BACKGROUND: White striping (WS) is an emerging muscular defect occurring on breast and thigh muscles of broiler chickens. It is characterized by the presence of white striations parallel to the muscle fibers and has significant consequences for meat quality. The etiology of WS remains poorly understood, even if previous studies demonstrated that the defect prevalence is related to broiler growth and muscle development. Moreover, recent studies showed moderate to high heritability values of WS, which emphasized the role of genetics in the expression of the muscle defect...
March 20, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29546320/relationship-of-physical-function-to-single-muscle-fiber-contractility-in-older-adults-effects-of-resistance-training-with-and-without-caloric-restriction
#8
Zhong-Min Wang, Xiaoyan Leng, María Laura Messi, Seung J Choi, Anthony P Marsh, Barbara Nicklas, Osvaldo Delbono
Background: Previous studies support beneficial effects of both resistance exercise training (RT) and caloric restriction (CR) on skeletal muscle strength and physical performance. The goal of this study was to determine the effects of adding CR to RT on single-muscle fiber contractility responses to RT in older overweight and obese adults. Methods: We analyzed contractile properties in 1,253 single myofiber from muscle biopsies of the vastus lateralis, as well as physical performance and thigh muscle volume, in 31 older (65-80 yrs), overweight or obese (body mass index= 27-35 kg/m2) men (n=19) and women (n=12) who were randomly assigned to a standardized, progressive RT intervention with CR (RT+CR; n=15) or without CR (RT; n=16) for 5 months...
March 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29539400/five-alternative-myosin-converter-domains-influence-muscle-power-stretch-activation-and-kinetics
#9
Bernadette M Glasheen, Seemanti Ramanath, Monica Patel, Debra Sheppard, Joy T Puthawala, Lauren A Riley, Douglas M Swank
Muscles have evolved to power a wide variety of movements. A protein component critical to varying power generation is the myosin isoform present in the muscle. However, how functional variation in muscle arises from myosin structure is not well understood. We studied the influence of the converter, a myosin structural region at the junction of the lever arm and catalytic domain, using Drosophila because its single myosin heavy chain gene expresses five alternative converter versions (11a-e). We created five transgenic fly lines, each forced to express one of the converter versions in their indirect flight muscle (IFM) fibers...
March 13, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29510741/a-missense-mutation-in-myh1-is-associated-with-susceptibility-to-immune-mediated-myositis-in-quarter-horses
#10
Carrie J Finno, Giuliana Gianino, Sudeep Perumbakkam, Zoë J Williams, Matthew H Bordbari, Keri L Gardner, Erin Burns, Sichong Peng, Sian A Durward-Akhurst, Stephanie J Valberg
BACKGROUND: The cause of immune-mediated myositis (IMM), characterized by recurrent, rapid-onset muscle atrophy in Quarter Horses (QH), is unknown. The histopathologic hallmark of IMM is lymphocytic infiltration of myofibers. The purpose of this study was to identify putative functional variants associated with equine IMM. METHODS: A genome-wide association (GWA) study was performed on 36 IMM QHs and 54 breed matched unaffected QHs from the same environment using the Equine SNP50 and SNP70 genotyping arrays...
March 6, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29510454/needle-electromyography-practice-patterns-in-patients-taking-novel-oral-anticoagulants-a-survey-based-study
#11
Ikjae Lee, Hani Kushlaf
INTRODUCTION: The aim of this study was to evaluate needle electromyography (EMG) practice patterns among electromyographers in patients taking novel oral anticoagulants (NOACs). METHODS: A survey questionnaire was sent to members of the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) via email weblink. Anonymous survey responses were collected through an online website. RESULTS: 58 AANEM members responded, 28 (48%) of whom worked at a teaching hospital and 30 (52%) in a private setting...
March 6, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29502978/combined-transplantation-of-mesenchymal-stem-cells-and-endothelial-progenitor-cells-restores-cavernous-nerve-injury-related-erectile-dysfunction
#12
Jia-Feng Fang, Xu-Na Huang, Xiao-Yan Han, Xi Ouyang, Lei Fan, Xin Zhao, Ze-Hong Chen, Hong-Bo Wei
BACKGROUND: Whether combined transplantation of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) is more effective than transplantation of a single cell type in the restoration of erectile function is unknown. AIM: To investigate the effect of combined transplantation of MSCs and EPCs on restoration of erectile function in rats with cavernous nerve injury (CNI). METHODS: MSCs were isolated from human bone marrow and EPCs were isolated from human umbilical cord blood...
March 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29498943/increased-single-fiber-jitter-level-is-associated-with-reduction-in-motor-function-with-aging
#13
Tae Chung, Yanli Tian, Jeremy Walston, Ahmet Hoke
OBJECTIVE: Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions (NMJ) in age-associated muscle weakness. Given this, we aim to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness...
March 1, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29464938/reliability-of-maximal-mitochondrial-oxidative-phosphorylation-in-permeabilized-fibers-from-the-vastus-lateralis-employing-high-resolution-respirometry
#14
Daniele A Cardinale, Kasper D Gejl, Niels Ørtenblad, Bjorn Ekblom, Eva Blomstrand, Filip J Larsen
The purpose was to assess the impact of various factors on methodological errors associated with measurement of maximal oxidative phosphorylation (OXPHOS) in human skeletal muscle determined by high-resolution respirometry in saponin-permeabilized fibers. Biopsies were collected from 25 men to assess differences in OXPHOS between two muscle bundles and to assess the correlation between OXPHOS and the wet weight of the muscle bundle. Biopsies from left and right thighs of another five subjects were collected on two occasions to compare limbs and time-points...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29441694/presynaptic-congenital-myasthenic-syndrome-with-altered-synaptic-vesicle-homeostasis-linked-to-compound-heterozygous-sequence-variants-in-rph3a
#15
Ricardo A Maselli, Jessica Vázquez, Leah Schrumpf, Juan Arredondo, Marian Lara, Jonathan B Strober, Peter Pytel, Robert L Wollmann, Michael Ferns
BACKGROUND: Monogenic defects of synaptic vesicle (SV) homeostasis have been implicated in many neurologic diseases, including autism, epilepsy, and movement disorders. In addition, abnormal vesicle exocytosis has been associated with several endocrine dysfunctions. METHODS: We report an 11 year old girl with learning disabilities, tremors, ataxia, transient hyperglycemia, and muscle fatigability responsive to albuterol sulfate. Failure of neuromuscular transmission was confirmed by single fiber electromyography...
February 14, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29432614/identification-of-an-ac-n-microsatellite-in-the-six1-gene-promoter-and-its-effect-on-production-traits-in-pietrain-%C3%A3-duroc-%C3%A3-landrace-%C3%A3-yorkshire-pigs
#16
W J Wu, K Q Liu, B J Li, C Dong, Z K Zhang, P H Li, R H Huang, W Wei, J Chen, H L Liu
The Sine oculis homeobox 1 (Six1) gene is important for skeletal muscle growth and fiber specification; therefore, it is considered as a promising candidate gene that may influence porcine growth and meat quality traits. Nevertheless, the association of Six1 with these processes, and the mechanisms regulating its expression, remain unclear. The objectives of this study were to identify variant sites of in Six1 in different pig breeds, conduct association analysis to evaluated the relationship between polymorphisms of theses variants and porcine production traits in Pietrainm × Duroc × Landrace × Yorkshire (P×D×L×Y) commercial pigs, and explore the potential regulatory mechanisms of Six1 affecting production traits...
February 8, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29417745/effect-of-speed-endurance-training-and-reduced-training-volume-on-running-economy-and-single-muscle-fiber-adaptations-in-trained-runners
#17
Casper Skovgaard, Danny Christiansen, Peter M Christensen, Nicki W Almquist, Martin Thomassen, Jens Bangsbo
The aim of the present study was to examine whether improved running economy with a period of speed endurance training and reduced training volume could be related to adaptations in specific muscle fibers. Twenty trained male (n = 14) and female (n = 6) runners (maximum oxygen consumption (VO2 -max): 56.4 ± 4.6 mL/min/kg) completed a 40-day intervention with 10 sessions of speed endurance training (5-10 × 30-sec maximal running) and a reduced (36%) volume of training. Before and after the intervention, a muscle biopsy was obtained at rest, and an incremental running test to exhaustion was performed...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29412689/branched-fibers-from-old-fast-twitch-dystrophic-muscles-are-the-sites-of-terminal-damage-in-muscular-dystrophy
#18
Leonit Kiriaev, Sindy Kueh, John W Morley, Kathryn N North, Peter J Houweling, Stewart I Head
A striking pathological feature of dystrophinopathies is the presence of morphologically abnormal branched skeletal muscle fibers. The deterioration of muscle contractile function in Duchenne muscular dystrophy is accompanied by both an increase in number and complexity of these branched fibers. We propose that when number and complexity of branched fibers reaches a critical threshold, "tipping point" the branches in and of themselves are the site of contraction-induced rupture. In the present study, we use the dystrophic mdx mouse and littermate controls to study the pre-diseased dystrophic fast-twitch EDL muscle at 2-3-weeks, the peak myonecrotic phase at 6-9 weeks and finally "old" at 58-112 weeks...
February 7, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29405034/revisiting-the-gamma-loop-in-als
#19
Fiona Limanaqi, Stefano Gambardella, Gloria Lazzeri, Michela Ferrucci, Stefano Ruggieri, Francesco Fornai
Amyotrophic Lateral Sclerosis (ALS) is a fast progressive neurodegenerative disease characterized by muscle denervation, weakening and atrophy, which eventually culminates into death, mainly due to respiratory failure. The traditional view of ALS as a disorder affecting selectively motor neurons throughout the central nervous system has been progressively dispelled by innumerous lines of evidence indicating that other cells but motor neurons may be affected as well. Remarkably, this disorder is not limited to the motor system but rather configures as a systemic disease yielding a plethora of clinical signs...
December 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29390370/coexisting-myasthenia-gravis-myositis-and-polyneuropathy-induced-by-ipilimumab-and-nivolumab-in-a-patient-with-non-small-cell-lung-cancer-a-case-report-and-literature-review
#20
Jia-Hung Chen, Kang-Yun Lee, Chaur-Jong Hu, Chen-Chih Chung
RATIONALE: Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death. PATIENT CONCERNS: We presented a case of a 57-year-old man with non-small-cell lung cancer.who developed ptosis, dyspnea, and muscle weakness as initial symptoms with progression after the treatment with ipilimumab and nivolumab...
December 2017: Medicine (Baltimore)
keyword
keyword
47073
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"