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https://www.readbyqxmd.com/read/28641881/peripheral-blood-regulatory-t-cell-counts-as-a-predictive-biomarker-for-the-outcome-of-kidney-transplant-a-systematic-review
#1
Francisco Herrera-Gómez, Mónica Vásquez-Seoane, Waldo Del Aguila, Débora Martín-García, Álvaro Maurtua-Briseño Meiggs, Anunciación González-López, Beatriz Andrés-Martín, Álvaro Nava-Rebollo, Fernando Casquero-Fernández, Pilar Pascual-Núñez, Jesús Grande-Villoria, Jesús Bustamante-Bustamante, Carlos Ochoa-Sangrador, Claude Lambert, Alicia Mendiluce-Herrero
BACKGROUND AND OBJECTIVE: Circulating regulatory T cells could become a suitable biomarker for kidney recipients. The objective of this study was to evaluate the effect of mammalian target of rapamycin (mTOR) inhibitors on regulatory T cell numbers, and the clinical interest of this effect. MATERIAL AND METHODS: Systematic review of published and unpublished studies. Worldwide databases or repositories. Randomised controlled trials and cohort studies comparing regulatory T cell counts and rejection episodes between patients with and without mTOR inhibitors were searched...
June 19, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28639098/a-head-to-head-comparison-of-xinsorb-bioresorbable-sirolimus-eluting-scaffold-versus-metallic-sirolimus-eluting-stent-180-days-follow-up-in-a-porcine-model
#2
Li Shen, Yizhe Wu, Lei Ge, Yaojun Zhang, Qibing Wang, Juying Qian, Zhifen Qiu, Junbo Ge
We aimed to investigate the safety and efficacy of XINSORB bioresorbable sirolimus-eluting scaffold in porcine model. XINSORB scaffolds and metallic Firebird2™ stents were randomly implanted into minipigs' coronary arteries. Angiography, optical coherent tomography (OCT) and histopathological analyses were performed at post-procedure and 14-, 28-, 90-, 180-day follow-up. Thirty-two minipigs were enrolled. Eight XINSORB scaffolds and 8 Firebird2 stents were examined at each time point. Quantitative coronary angiography showed that in-scaffold late luminal loss (LLL) of XINSORB scaffold was 0...
June 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28626202/stent-fracture-and-peri-stent-contrast-staining-after-everolimus-eluting-stent-implantation%C3%A3-5-year-outcomes
#3
Katsuya Miura, Takeshi Tada, Akinune Kuwayama, Takenobu Shimada, Masanobu Ohya, Hidewo Amano, Shunsuke Kubo, Yusuke Hyodo, Suguru Otsuru, Seiji Habara, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota
BACKGROUND: Stent fracture (SF) and peri-stent contrast staining (PSS) after sirolimus-eluting stent implantation are reported to be risk factors of adverse events. However, the effect of these after everolimus-eluting stent (EES) implantation on long-term outcomes remains unclear.Methods and Results:The study sample comprised 636 patients (1,081 lesions) undergoing EES implantation in 2010 and follow-up angiography within 1 year. The 5-year cumulative rates of target lesion revascularization (TLR) and major adverse cardiac events (MACE: a combination of all-cause death, myocardial infarction, and TLR) were compared between patients with and without SF or PSS...
June 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28625629/a-phase-ib-trial-of-continuous-once-daily-oral-afatinib-plus-sirolimus-in-patients-with-epidermal-growth-factor-receptor-mutation-positive-non-small-cell-lung-cancer-and-or-disease-progression-following-prior-erlotinib-or-gefitinib
#4
Teresa Moran, Ramón Palmero, Mariano Provencio, Amelia Insa, Margarita Majem, Noemí Reguart, Joaquim Bosch-Barrera, Dolores Isla, Enric Carcereny Costa, Chooi Lee, Marta Puig, Sandrine Kraemer, David Schnell, Rafael Rosell
OBJECTIVES: Dysregulation of the downstream PI3K/AKT/mTOR signaling pathway is a proposed mechanism of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). We investigated safety and antitumor activity of afatinib plus sirolimus as a potential combination to reverse acquired resistance to EGFR-TKIs in a phase IB trial in patients with EGFR mutation-positive non-small-cell lung cancer (EGFR mut NSCLC) and/or disease progression following prior erlotinib/gefitinib...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28621877/autoimmune-hemolytic-anemia-in-solid-organ-transplantation-the-role-of-immunosuppression
#5
REVIEW
Theoni Kanellopoulou
Hemolysis after solid organ transplantation can be caused by both immune and non-immune mediated mechanisms and the evaluation must take into account issues distinctive to the post-transplant period. Autoimmune hemolytic anemia usually occurs within the first year and has been attributed to immunosuppressive treatment, infections or underlying post-transplant lymphoproliferative disorder. Review of the literature revealed 59 cases with autoimmune hemolytic anemia mostly in children after liver transplantation...
June 16, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28616540/the-fate-of-small-side-branches-following-drug-eluting-stent-implantation
#6
Demet Ozkaramanli Gur, Deniz Kumbasar, Refika Hüral, Derviş Oral, Çetin Erol
OBJECTIVES: Although drug eluting stents (DES) have documented convenience in bifurcation lesions, possible unfavorable effects on small side branch ostium (SBO) remain a question. We aimed to explore the effects of DES on small jailed SBs (1.5-2.25 mm) which originated from the lesion on the main vessel and were not treated with either stenting or balloon dilatation. METHODS: Angiographic data of 107 consecutive patients (129 SB) with Medina 1,1,1 or 1,1,0 lesions were evaluated at the time of procedure and at the follow-up...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28616377/blue-after-splenectomy
#7
Taaran Cariappa Ballachanda Subbaiah, Jeremy P Feldman
INTRODUCTION: We present a 51 year old, African American, female who presented with persistent hypoxemia. She had been taking dapsone for many years for prophylaxis against Pneumocystic Jiroveci with no symptoms but eventually developed methemoglobinemia only after a splenectomy. From our literature review there are no documented cases that have demonstrated this relationship between dapsone, splenic function and methemoglobin and we hope to share our perplexing case and shed light on the interaction...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28595861/comparison-of-outcome-of-coronary-artery-bypass-grafting-versus-drug-eluting-stent-implantation-for-non-st-elevation-acute-coronary-syndrome
#8
Mineok Chang, Cheol Whan Lee, Jung-Min Ahn, Rafael Cavalcante, Yohei Sotomi, Yoshinobu Onuma, Minkyu Han, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Patrick W Serruys, Seung-Jung Park
There is limited data comparing effectiveness of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) with drug-eluting stents in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). We compared the long-term outcomes of the 2 revascularization strategies in 1,246 patients presented with NSTE-ACS for left main or multivessel coronary artery disease. Data were pooled from the Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients with Multivessel Coronary Artery Disease (BEST) trial, the Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease (PRECOMBAT) trial, and the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial...
May 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28593920/influence-of-cyp3a4-and-cyp3a5-polymorphisms-on-tacrolimus-and-sirolimus-exposure-in-stable-kidney-transplant-recipients
#9
Erika Y Tamashiro, Claudia R Felipe, Fabiana D V Genvigir, Alice C Rodrigues, Antony B Campos, Rosario D C Hirata, Helio Tedesco-Silva, Jose O Medina-Pestana
BACKGROUND: Polymorphisms in genes encoding for drug-metabolizing enzymes and drug transporters are among multiple factors that modulate the pharmacokinetic variability of tacrolimus (TAC) and sirolimus (SRL). This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) on TAC and SRL dose-adjusted concentrations (C0/D) in stable kidney transplant recipients. METHODS: This is an exploratory and prospective study, which includes 46 stable kidney transplant recipients...
May 24, 2017: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/28590249/difference-in-hemodynamic-microenvironment-in-vessels-scaffolded-with-absorb-bvs-and-mirage-brms-insights-from-a-pre-clinical-endothelial-shear-stress-study
#10
Erhan Tenekecioglu, Ryo Torii, Christos Bourantas, Yohei Sotomi, Rafael Cavalcante, Yaping Zeng, Carlos Collet, Tom Crake, Pannipa Suwannasom, Yoshinobu Onuma, Patrick W Serruys
AIMS: In silico studies have provided robust evidence that stent design affects local hemodynamic forces, which appear as a major determinant of clinical outcomes following stent implantation. However, implications of different stent/scaffold configurations on local hemodynamic forces have not yet been investigated in vivo in a comparative fashion. METHOD AND RESULTS: Eight healthy mini pigs were implanted with six Absorb everolimus-eluting Bioresorbable Vascular Scaffolds (Absorb BVS) and five Mirage sirolimus-eluting Bioresorbable Microfiber Scaffolds (Mirage BRMS)...
June 6, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28583549/reduction-of-slit-diaphragm-associated-molecules-by-sirolimus-is-it-enough-to-induce-proteinuria
#11
B S Kim, J G Lee, Y Cho, S H Song, K H Huh, M S Kim, Y S Kim
Sirolimus (SRL), a mammalian target of rapamycin inhibitor, is widely used in transplantation, but the mechanisms whereby it induces adverse effects, such as proteinuria and edema, remain unclear. To determine whether isolated SRL induces proteinuria or not, the authors intraperitoneally injected C57BL/6 mice with different doses of SRL (0 mg/[kg·d], 3 mg/[kg·d], 10 mg/[kg·d], or 30 mg/[kg·d]) for 24 days. Urinary albumin excretion was then quantified using a double-sandwich enzyme-linked immunosorbent assay, and serum creatinine levels were measured using a single dry-film chemistry auto-analyzer...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28581472/low-incidence-of-severe-cgvhd-and-late-nrm-in-a-phase-ii-trial-of-thymoglobulin-tacrolimus-and-sirolimus-for-gvhd-prevention
#12
Z Al-Kadhimi, Z Gul, M Abidi, L G Lum, A Deol, W Chen, H Jang, C Ozust, A Langston, E Waller, J Uberti
Chronic GvHD (cGvHD) is the leading cause of late non-relapse mortality (NRM) and morbidity after allogeneic hematopoietic stem cell transplant (AHSCT). We analyzed the late effects of a phase II trial testing the efficacy of intermediate dose rabbit anti-thymocyte globulin (Thymoglobulin Thymo) in combination with tacrolimus and sirolimus (TTS) in 47 patients (pts) for the prevention of acute and chronic GvHD after unrelated AHSCT. The median follow-up was 45.2 months. The cumulative incidence of NIH severe cGvHD at 48 months was 6...
June 5, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28577037/metabolic-impact-of-rapamycin-sirolimus-and-b-estradiol-using-mouse-embryonic-fibroblasts-as-a-model-for-lymphangioleiomyomatosis
#13
Katherine M Marsh, David Schipper, Alice S Ferng, Kitsie Johnson, Julia Fisher, Shannon Knapp, Destiny Dicken, Zain Khalpey
INTRODUCTION: Lymphangioleiomyomatosis (LAM) is a rare, progressive cystic lung disease that predominantly affects women of childbearing age. Exogenous rapamycin (sirolimus) has been shown to improve clinical outcomes and was recently approved to treat LAM, whereas estrogen (E2) is implicated in disease progression. No consistent metabolic model currently exists for LAM, therefore wild-type mouse embryonic fibroblasts (MEF +/+) and TSC2 knockout cells (MEF -/-) were used in this study as a model for LAM...
June 2, 2017: Lung
https://www.readbyqxmd.com/read/28576630/ca-125-in-disease-progression-and-treatment-of-lymphangioleiomyomatosis
#14
Connie G Glasgow, Gustavo Pacheco-Rodriguez, Wendy K Steagall, Mary E Haughey, Patricia A Julien-Williams, Mario P Stylianou, Bernadette R Gochuico, Joel Moss
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women caused by proliferation of neoplastic-like LAM cells, with mutations in the TSC1/2 tumor suppressor genes. Based on case reports, CA-125 (an ovarian cancer biomarker) can be elevated in LAM patients. We hypothesized that elevated serum CA-125 levels seen in some LAM patients were due to LAM, not other malignancies, and might respond to sirolimus treatment. METHODS: Serum CA-125 levels were measured for 241 patients at each visit...
May 30, 2017: Chest
https://www.readbyqxmd.com/read/28576000/the-effect-of-solvents-and-hydrophilic-additive-on-stable-coating-and-controllable-sirolimus-release-system-for-drug-eluting-stent
#15
Seong Min Kim, Sung-Bin Park, Tarek M Bedair, Man-Ho Kim, Bang Ju Park, Yoon Ki Joung, Dong Keun Han
Various drug-eluting stents (DESs) have been developed to prevent restenosis after stent implantation. However, DES still needs to improve the drug-in-polymer coating stability and control of drug release for effective clinical treatment. In this study, the cobalt-chromium (CoCr) alloy surface was coated with biodegradable poly(D,L-lactide) (PDLLA) and sirolimus (SRL) mixed with hydrophilic Pluronic F127 additive by using ultrasonic spray coating system in order to achieve a stable coating surface and control SRL release...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28570161/a-phase-ii-clinical-trial-of-an-aromatase-inhibitor-for-postmenopausal-women-with-lymphangioleiomyomatosis
#16
Calvin Lu, Hye-Seung Lee, George P Pappas, Daniel F Dilling, Charles D Burger, Adrian Shifren, Srihari Veeraraghavan, Jeffrey T Chapman, Joseph Parambil, Stephen J Ruoss, Lisa R Young, Stephen R Hammes, Elizabeth J Kopras, Tammy Roads, Jeffrey P Krischer, Francis X McCormack
RATIONALE: Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease that predominantly affects women and can worsen with pregnancy, estrogen treatment, and the menstrual cycle, suggesting an important role for estrogen in disease pathogenesis. OBJECTIVES: To assess the efficacy and safety of the aromatase inhibitor letrozole in the treatment of LAM. METHODS: Seventeen postmenopausal women with LAM were enrolled in this phase II trial and randomized to receive letrozole 2...
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28566443/hypoinsulinaemic-hypoketotic-hypoglycaemia-due-to-mosaic-genetic-activation-of-pi3-kinase
#17
Sarah Maria Leiter, Victoria Er Parker, Alena Welters, Rachel Knox, Nuno Rocha, Graeme R Clark, Felicity Payne, Luca Lotta, Julie Harris, Julio Guerrero-Fernández, Isabel González-Casado, Sixto García-Miñaur, Gema Gordo, N J Wareham, Victor Martínez-Glez, Michael Allison, Stephen O'Rahilly, Ines Barroso, Thomas Meissner, Susan Davies, Khalid Hussain, Karen Temple, Ana-Carol Barreda-Bonis, Sebastian Kummer, Robert Kenneth Semple
OBJECTIVE: Genetic activation of the insulin signal-transducing kinase AKT2 causes syndromic hypoketotic hypoglycaemia without elevated insulin. Mosaic activating mutations in class 1A phospatidylinositol-3-kinase (PI3K), upstream from AKT2 in insulin signalling, are known to cause segmental overgrowth, but the metabolic consequences have not been systematically reported. We assess the metabolic phenotype of 22 patients with mosaic activating mutations affecting PI3K, thereby providing new insight into the metabolic function of this complex node in insulin signal transduction...
May 31, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28556421/gastrointestinal-disorders-after-immunosuppression-an-experimental-model-to-evaluate-the-influence-of-monotherapy-on-motility-parameters
#18
Denize Jussara Rupolo Dall'Agnol, Luciana Aparecida Corá, Maria do Carmo Borges Teixeira, Maysa Bruno de Lima, Loyane Almeida Gama, José Ricardo de Arruda Miranda, Madileine Francely Américo
OBJECTIVES: The aim was to propose an animal model for investigating the effects of immunosuppressive monotherapy on gastrointestinal motility using a non-invasive biomagnetic technique. METHODS: Male Wistar rats were randomly distributed into groups: Cyclosporine, Tacrolimus, Prednisone, Sirolimus, Mycophenolate Mofetil, Everolimus and Azathioprine. Each animal was treated during 14 days by gavage with dosage ranging from 1 to 20 mg Kg(-1)  day(-1) considering area per volume ratio and hepatic metabolism...
May 26, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28553050/successful-treatment-of-multiple-angiomyolipomas-with-sirolimus-in-a-child
#19
K Pabedinskas, M Kobrzynski, G Filler
Tuberous sclerosis complex frequently results in the formation of renal angiomyolipomas (AMLs). Sirolimus (SIR) or everolimus can be used to treat large AMLs, although this treatment has rarely been described in children, particularly for multiple renal AMLs. A 15-year-old girl presented with bilateral severe chronic flank pain coinciding with increased renal size and hundreds of renal AMLs. We opted to treat her with SIR over the course of 3.5 years. Following her treatment, her renal size had substantially decreased and the AMLs had shrunk...
May 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28548953/from-rapalogs-to-anti-aging-formula
#20
Mikhail V Blagosklonny
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor...
May 30, 2017: Oncotarget
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