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https://www.readbyqxmd.com/read/28398655/seasonal-variations-in-tsh-serum-levels-in-athyreotic-patients-under-l-thyroxine-replacement-monotherapy
#1
Damiano Gullo, Adele Latina, Francesco Frasca, Sebastiano Squatrito, Antonino Belfiore, Riccardo Vigneri
BACKGROUND: Whether serum TSH undergoes seasonal fluctuations in euthyroid and hypothyroid residents of temperate climates is controversial. METHODS: Monthly TSH and thyroid hormone levels were cross-sectionally analyzed in a large cohort of euthyroid subjects (n=11,806) and L-thyroxine (L-T4)-treated athyreotic patients (n=3,934). Moreover, in a small group (n=119) of athyreotic patients treated with an unchanged dosage of L-T4 monotherapy, hormones were measured both in the coldest and the hottest seasons of the same year (longitudinal study)...
April 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28375832/fatigue-in-patients-with-systemic-sclerosis-and-hypothyroidism-a-review-of-the-literature-and-report-of-our-experience
#2
Alessandro Antonelli, Poupak Fallahi, Flavia Di Bari, Dilia Giuggioli, Silvia Martina Ferrari, Clodoveo Ferri
Persistent fatigue (defined as ongoing exhaustion, disproportionate to exertion and not adequately alleviated by rest) reduces health-related quality of life of systemic sclerosis (SSc) patients. Fatigue in SSc is associated with reduced capacity to carry out daily activities, work disability and impaired physical function. Clinical studies demonstrated a high prevalence of autoimmune thyroiditis and hypothyroidism in patients with SSc. Since hypothyroidism and the associated fatigue symptoms could be cured by L-thyroxine (L-T4) substitutive therapy, the evolution of fatigue symptoms in SSc hypothyroid patients treated with substitutive therapy has been recently evaluated, showing an amelioration of the fatigue symptoms...
April 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28358714/effects-of-l-thyroxine-treatment-on-heart-functions-in-infants-with-congenital-hypothyroidism
#3
Alev Arslan, Veysel Nijat Baş, Salih Uytun, Hatice Gamze Poyrazoğlu
BACKGROUND: Impaired heart functions in newborns with hypothyroidism should be reversed by levothyroxine substitution therapy. The aim of the study was to investigate heart functions with congenital hypothroidism (CH) in newborns and changes after levothyroxine substitution therapy, measured with tissue Doppler echocardiography and conventional echocardiography. METHODS: The study included 30 neonates with CH and 34 healthy controls. Echocardiography were performed at baseline, 2nd week and 6th month of therapy...
March 30, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28342184/the-lipid-lowering-effect-of-levothyroxine-in-patients-with-subclinical-hypothyroidism-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
Xiang Li, Yupeng Wang, Qingbo Guan, Jiajun Zhao, Ling Gao
OBJECTIVES: Dyslipidaemia is common in patients with subclinical hypothyroidism (SCH). To date, there is no universal agreement regarding the lipid-lowering effect of substitution treatment with L-T4 in patients with SCH. We aimed to clarify the effect by conducting this systematic review and meta-analysis of randomized controlled trials (RCTs). DESIGN: We systematically searched PubMed, the Cochrane Library, ClinicalTrials. gov and EMBASE for RCTs comparing substitution treatment to placebo treatment or observation...
March 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28249913/alteration-of-hemostatic-parameters-in-patients-with-different-levels-of-subclinical-hypothyroidism-and-the-effect-of-l-thyroxine-treatment
#5
Fang Gao, Guangya Wang, Jinxiu Xu
Subclinical hypothyroidism (SH) is associated with hypercoagulability and hypofibrinolysis. The objective of this study was to assess the effect of L-thyroxine (L-T4) treatment and to evaluate changes in the hemostatic abnormalities of patients with varying severities of SH. We measured tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), D-dimer (DDI), fibrinogen (FIB), platelet counts (PLT), mean platelet volume (MPV), platelet distribution width (PDW), activated partial thromboplastin time (APTT), and prothrombin time (PT) in 149 female subjects...
January 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28213226/a-feasible-method-for-indirect-quantification-of-l-t4-in-drugs-by-iodine-determination
#6
Marcia Foster Mesko, Alessandra Cortes Teotonio, Dirce Taina Teixeira Oliveira, Diogo La Rosa Novo, Vanize Caldeira Costa
In this work, a method combining microwave-induced combustion (MIC) for sample preparation of commercial levothyroxine sodium (L-T4) drugs (L-T4: 25-200µg/tablet), and potentiometry with ion selective electrode (ISE) for iodine determination and subsequent indirect quantification of L-T4 was proposed. The type and concentration of the absorbing solution were evaluated to select the most suitable conditions for this study. Using the MIC method, it was possible to use solutions as diluted as 150mmolL(-1) (NH4)2CO3 (for samples containing 25-200µg of L-T4/tablet) for I absorption...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28207545/primary-hypothyroidism-in-the-community-lower-daily-dosages-of-levothyroxine-replacement-therapy-for-asian-patients
#7
Ngiap Chuan Tan, Rong Quan Chew, Yi Ling Eileen Koh, Reena Chandini Subramanian, Usha Sankari, Meykkumar Meyappan, Li Wei Cho
The goal of treatment in patients with primary hypothyroidism is to attain euthyroidism guided by the stipulated thyroid-stimulating hormone (TSH) levels range so as to minimize any potential long-term adverse effects. However, various factors may result in their Levothyroxine (T4) under and over-replacement.Our study aimed to evaluate the mean daily dose of L-T4 replacement for Asian patients with primary hypothyroidism. The secondary aims were to determine the proportion of those who were either over or under-replaced, and the factors associated with their thyroid function status and replacement adherence...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28151692/oral-liquid-levothyroxine-solves-the-problem-of-tablet-levothyroxine-malabsorption-due-to-concomitant-intake-of-multiple-drugs
#8
Roberto Vita, Flavia Di Bari, Salvatore Benvenga
BACKGROUND: Unlike the tablet (TAB) formulation, liquid L-T4 (LIQ) is directly absorbed in the intestine. The aim of this study was to assess whether LIQ was superior to TAB, such that it would overcome the interference induced by co-ingestion of multiple interfering drugs (ID). METHODS: In this prospective cohort study, we recruited 11 patients with apparent reduced TAB absorption due to ≥ 2 ID, and switched them to LIQ while maintaining the daily dose and the co-ingestion of the ID...
February 13, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28125093/effect-of-l-thyroxine-supplementation-on-very-low-birth-weight-infants-with-transient-hypothyroxinemia-of-prematurity-at-3-years-of-age
#9
A Uchiyama, R Kushima, T Watanabe, S Kusuda
OBJECTIVE: To evaluate the effects of levothyroxine (L-T4) supplementation on growth and neurodevelopmental outcomes at 3 years of age in very low birth weight (VLBW) infants with transient hypothyroxinemia of prematurity (THOP). STUDY DESIGN: VLBW infants with plasma thyroid-stimulating hormone concentrations <10 mIU l(-1) and free thyroxine concentrations <0.8 ng dl(-1) were defined as having THOP and randomly assigned to the Treated (20 infants) or Untreated (31 infants) group...
January 26, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27973686/effects-of-electromagnetic-fields-on-bone-loss-in-hyperthyroidism-rat-model
#10
Chaoxu Liu, Yingchi Zhang, Tao Fu, Yang Liu, Sheng Wei, Yong Yang, Dongming Zhao, Wenchun Zhao, Mingyu Song, Xiangyu Tang, Hua Wu
Optimal therapeutics for hyperthyroidism-induced osteoporosis are still lacking. As a noninvasive treatment, electromagnetic fields (EMF) have been proven to be effective for treating osteoporosis in non-hyperthyroidism conditions. We herein systematically evaluated the reduced effects of EMF on osteoporosis in a hyperthyroidism rat model. With the use of Helmholtz coils and an EMF stimulator, 15 Hz/1 mT EMF was generated. Forty-eight 5-month-old male Sprague-Dawley rats were randomly divided into four different groups: control, levothyroxine treated (L-T4), EMF exposure + levothyroxine (EMF + L-T4), and EMF exposure without levothyroxine administration (EMF)...
February 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/27902975/timing-of-hormone-withdrawal-in-children-undergoing-131i-whole-body-scans-for-thyroid-cancer
#11
Sophie Turpin, Raymond Lambert, Cheri Deal
BACKGROUND: Little objective pediatric data exist to guide the optimal time needed to achieve thyroid-stimulating hormone (TSH) levels ≥30 μIU/mL prior to performing 131I or 123I whole-body scan (WBS) imaging in children with thyroid cancer in the post-thyroidectomy period or after hormone discontinuation. METHODS: Retrospective study of patients aged 5-19 years who underwent WBS. Patient data collection included type and duration of withdrawal (liothyronine [L-T3], levothyroxine [L-T4], or post-thyroidectomy status without hormonal replacement) and TSH measured prior to WBS (level and timing)...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27886341/clinical-efficacy-of-therapeutic-intervention-for-subclinical-hypothyroidism-during-pregnancy
#12
R Ju, L Lin, Y Long, J Zhang, J Huang
This study explored the effects of levothyroxine (L-T4) replacement therapy on pregnancy outcomes in patients with subclinical hypothyroidism (SCH). We analyzed the effects on pregnancy outcomes with respect to gestational week when the desired thyroid-stimulating hormone (TSH) level was reached as well as the length of time required to reach the target level during L-T4 treatment. This study enrolled 457 patients diagnosed with SCH upon initial thyroid function screening. Subjects were assigned to the treatment group (N = 184), and the control group (N = 273)...
November 21, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27849377/in-patients-with-subclinical-hypothyroidism-while-in-therapy-with-tablet-l-t4-the-liquid-l-t4-formulation-is-more-effective-in-restoring-euthyroidism
#13
Poupak Fallahi, Silvia Martina Ferrari, Alessandro Antonelli
OBJECTIVE: Levothyroxine (L-T4) is the standard therapy of hypothyroidism. Our purpose was to compare the effectiveness of the L-T4 liquid formulation with respect to L-T4 tablet in hypothyroid patients without malabsorption or drug interference. Twenty-one subjects with high thyroid-stimulating hormone (TSH) values under therapy with L-T4 tablets were switched to liquid L-T4 at the same dosage given 30 minutes before breakfast. RESULTS: TSH values significantly declined 2 months after from the switch to liquid L-T4, reaching the normal range in most cases...
February 2017: Endocrine Practice
https://www.readbyqxmd.com/read/27737898/diagnosis-of-endocrine-disease-how-reliable-are-free-thyroid-and-total-t3-hormone-assays
#14
REVIEW
Kerry J Welsh, Steven J Soldin
Hypothyroidism is a very common disorder worldwide, for which the usual treatment is monotherapy with levothyroxine (L-T4). However, a number of patients treated with L-T4 continue to report symptoms of hypothyroidism despite seemingly normal levels of thyroid-stimulating hormone (TSH), free-T3 (FT3) and free-T4 (FT4) measured by immunoassay. This review summarizes the limitations of the immunoassays commonly used to measure thyroid hormone levels and emphasizes the advantages of the role of liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27718637/new-levothyroxine-formulation-meeting-95-105-specification-over-the-whole-shelf-life-results-from-two-pharmacokinetic-trials
#15
Ulrike Gottwald-Hostalek, Wolfgang Uhl, Peter Wolna, George J Kahaly
OBJECTIVE: Small levothyroxine (L-T4) dose changes can lead to significant clinical effects. To ensure thyroid hormone levels are safely maintained, authorities are increasingly adopting stricter potency specifications for L-T4, the most stringent of these being 95-105% of the labeled dose over the whole shelf-life. Levothyroxine sodium (Euthyrox, Eutirox, Lévothyrox ) has been reformulated, and two studies performed, to ensure bioequivalence to the currently marketed formulation and dosage form proportionality of the new formulation...
February 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27640349/central-and-peripheral-administrations-of-levothyroxine-improved-memory-performance-and-amplified-brain-electrical-activity-in-the-rat-model-of-alzheimer-s-disease
#16
Sahreh Shabani, Alireza Sarkaki, Seyyed Ali Mard, Akram Ahangarpour, Layasadat Khorsandi, Yaghoob Farbood
Alzheimer's disease (AD) is associated with cognitive impairments and a decline in the spontaneous neuronal discharge. In the current study, we evaluated the effect of subcutaneous (S.C.) and intrahippocampal (I.H.) administrations of levothyroxine (LT-4) on the passive avoidance and spatial memory, as well as electrophysiological activity in an animal model of AD. One hundred-sixty male Wistar rats were divided into two main groups. The S.C. group included two Sham and four AD (vehicle or L-T4 25, 50 & 100μg/kg); and the I...
October 2016: Neuropeptides
https://www.readbyqxmd.com/read/27618219/cardiovascular-risk-assessment-of-subclinical-hypothyroid-patients-by-using-framingham-risk-score
#17
Y Sertbas, Y Akcan, M Yazici
Objectives: The aim of this study is to evaluate the variation of cardiovascular risks of subclinical hypothyroid patients with thyroid hormone replacement therapy by using Framingham Risk Scoring system. Materials and methods: In this study 21 subclinical hypothyroid and 22 healthy volunteers, between the ages 37 to 68 were taken as cases and control groups. Subclinical hypothyroid patients were given L-T4 replacement therapy for one-year to keep the thyroid hormone (TSH) values in normal ranges...
October 16, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27561715/role-of-a-gitogenin-type-steroidal-saponin-3-o-%C3%AE-d-glucopyranosyl-1%C3%A2-2-%C3%AE-d-glucopyranosyl-1%C3%A2-4-%C3%AE-d-galactopyranoside-25r-5%C3%AE-spirostane-2%C3%AE-3%C3%AE-diol-isolated-from-the-leaves-of-malvastrum-coromandelianum-in-regulating-thyrotoxicosis-in-rats
#18
Sunanda Panda, Anand Kar
The hitherto unknown role of saponin in the regulation of thyrotoxicosis has been revealed in chemically-induced thyrotoxic rats. l-T4 (l-thyroxine) administration at pre-standardized dose of 500-μg/kg body weight for 12days increased the levels of thyroid hormones, enhanced the activity of hepatic 5'-monodeiodinase I (5'DI) and glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO) with a parallel decrease in the levels of antioxidative enzymes. However, administration of the isolated saponin for 15days ameliorated the T4-induced alterations in serum thyroid hormones, hepatic LPO, G-6-Pase and 5'DI activity, and improved the cellular antioxidant status, indicating its antithyroidal and antioxidative potential...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27552635/advancements-in-the-treatment-of-hypothyroidism-with-l-t4-liquid-formulation-or-soft-gel-capsule-an-update
#19
Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli, Francesca Ragusa, Marco Biricotti, Gabriele Materazzi, Paolo Miccoli, Alessandro Antonelli
The most recent advance concerning levothyroxine (L-T4) therapy is the development of novel oral formulations: the liquid preparation, and the soft gel capsule. Areas covered: This review evaluates the most recent clinical studies about these new formulations. The liquid formulation has been shown to overcome: the food and beverages intereference with L-T4 tablets absorption, caused by food or coffee at breakfast; malabsorption induced by the increased gastric pH, resulting from atrophic gastritis, or due to proton-pump inhibitors; and malabsorption after bariatric surgery...
August 30, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27515774/levothyroxine-therapy-in-the-subclinical-hypothyroidism-a-lifelong-therapy-a-long-term-study
#20
LETTER
Pedro W Rosario, Maria R Calsolari
No abstract text is available yet for this article.
November 2016: Clinical Endocrinology
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