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https://www.readbyqxmd.com/read/28915159/contraception-in-us-servicewomen-emerging-knowledge-considerations-and-needs
#1
Lauren A Harrington, Kate A Shaw, Jonathan G Shaw
PURPOSE OF REVIEW: We describe current literature regarding contraceptive use among women serving in the military. We explore the state of contraceptive use by female servicewomen, gaps in knowledge, special considerations, and evidence of unmet needs. RECENT FINDINGS: Recent data on US servicewomen show that overall rates of contraceptive use remain low. Data highlight disparities and suggest barriers to contraceptive uptake persist, with contraceptive use being lower around the time of deployment...
September 14, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28888798/impact-of-body-mass-index-on-treatment-outcome-of-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#2
REVIEW
Y Sun, Z Xu, H Lin, X Lu, Y Huang, S Huang, X Wang, P Chi
AIM: To determine the effect of obesity, measured by body mass index (BMI), on tumor response and surgical outcome in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (nCRT) and radical surgery. METHOD: LARC patients undergoing nCRT and radical surgery from 2008 to 2014 were included and divided into three groups: non-obese (BMI < 25.0 kg/m(2)), obese I (BMI 25.0-29.9 kg/m(2)), and obese II (BMI ≥ 30.0 kg/m(2))...
August 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28887052/comparing-long-acting-reversible-contraception-insertion-rates-in-women-with-medicaid-vs-private-insurance-in-a-clinic-with-a-two-visit-protocol
#3
Tara M Higgins, Anne K Dougherty, Gary J Badger, Sarah H Heil
OBJECTIVE: This study examined whether women with Medicaid are less likely to receive long-acting reversible contraception (LARC) in a clinic requiring two visits for insertion. STUDY DESIGN: LARC insertion and pregnancy rates were compared among women with Medicaid vs. private insurance, along with other predictors, in a retrospective chart review (N=447). RESULTS: Univariately, fewer women with Medicaid vs. private insurance received LARC (66% vs...
September 5, 2017: Contraception
https://www.readbyqxmd.com/read/28885401/inpatient-postpartum-long-acting-reversible-contraception-care-that-promotes-reproductive-justice
#4
Michelle H Moniz, Kayte Spector-Bagdady, Michele Heisler, Lisa Hope Harris
Inpatient insertion of long-acting reversible contraceptives (LARC) (intrauterine devices and implants) is increasingly offered to women immediately after childbirth. Enthusiasm for this approach stems from robust safety, effectiveness, and cost-effectiveness data and responsiveness to women's needs and preferences. Although clinical evidence for immediate postpartum LARC is well-established, the ethical implications of enhancing access to this care have not been fully considered. Contraceptive policies and practices often embody a tension between fostering liberal availability and potentially coercive promotion of some methods...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28881464/immediate-postpartum-contraception-a-survey-needs-assessment-of-a-national-sample-of-midwives
#5
Michelle H Moniz, Lee Roosevelt, Halley P Crissman, Emily K Kobernik, Vanessa K Dalton, Michele H Heisler, Lisa Kane Low
INTRODUCTION: Immediate postpartum long-acting, reversible contraception (LARC)-providing intrauterine devices (IUDs) and contraceptive implants immediately following birth-is an effective strategy to prevent unintended pregnancies and improve birth spacing. We measured US certified nurse-midwives' (CNMs') and certified midwives' (CMs') knowledge, training needs, current practice, and perceived barriers to providing immediate postpartum LARC. METHODS: We invited currently practicing CNM and CM members of the American College of Nurse-Midwives to complete an online survey about their knowledge and experience with the use of LARC and analyzed eligible questionnaires using descriptive statistics...
September 7, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28870889/mir-194-as-predictive-biomarker-of-responsiveness-to-neoadjuvant-chemoradiotherapy-in-patients-with-locally-advanced-rectal-adenocarcinoma
#6
Edoardo D'Angelo, Carlo Zanon, Francesca Sensi, Maura Digito, Massimo Rugge, Matteo Fassan, Marco Scarpa, Salvatore Pucciarelli, Donato Nitti, Marco Agostini
AIMS: Curative surgery remains the primary form of treatment for locally advanced rectal cancer (LARC). Recent data support the use of preoperative chemoradiotherapy (pCRT) to improve the prognosis of LARC with a significant reduction of local relapse and an increase of overall survival. Unfortunately, only 20% of the patients with LARC present complete pathological response after pCRT, whereas in 20%-40%, the response is poor or absent. METHODS: We investigated the expression level of miR-194 in n=38 patients with LARC using our public microRNA (miRNA) expression dataset...
September 4, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28832936/chlamydia-testing-and-diagnosis-following-initiation-of-long-acting-reversible-contraception-a-retrospective-cohort-study
#7
Sally B Rose, Susan M Garrett, James Stanley, Susan R H Pullon
BACKGROUND: Long-acting reversible contraception (LARC) effectively protects against pregnancy but provides no protection against sexually transmitted infections (STIs). AIM: To compare rates of chlamydia testing and diagnosis for women initiating long-acting versus oral contraception. MATERIALS AND METHODS: Retrospective cohort study involving data collection for 6160 women initiating post-abortion contraception at a large New Zealand regional public hospital abortion clinic (2009-2012), with chlamydia testing data obtained from the local laboratory during two-year follow up...
August 22, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28830475/preoperative-intensity-modulated-radiotherapy-with-a-simultaneous-integrated-boost-combined-with-capecitabine-in-locally-advanced-rectal-cancer-short-term-results-of-a-multicentric-study
#8
Marco Lupattelli, Fabio Matrone, Maria Antonietta Gambacorta, Mattia Osti, Gabriella Macchia, Elisa Palazzari, Luca Nicosia, Federico Navarria, Giuditta Chiloiro, Vincenzo Valentini, Cynthia Aristei, Antonino De Paoli
BACKGROUND: Preoperative radiotherapy (RT) in combination with fluoropyrimidine-based chemotherapy (CT) is the standard of care in patients with locally advanced, T3-T4 N0-2, rectal cancer (LARC). Given the correlation between RT dose-tumor response and the prognostic role of the tumor regression grade (TRG), treatment intensification represents an area of active investigation. The aim of the study was to analyze the role of RT dose-intensification in the preoperative treatment of LARC in terms of feasibility, efficacy and toxicity...
August 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28830089/unexpected-complexity-in-the-lactate-racemization-system-of-lactic-acid-bacteria
#9
Benoît Desguin, Patrice Soumillion, Robert P Hausinger, Pascal Hols
Analysis of lactate racemase (Lar) in lactic acid bacteria (LAB) has been a scientific challenge for many years, as indicated by the numerous contradictory reports on this activity. Recently, genetic and biochemical studies of the Lar system of Lactobacillus plantarum have unveiled the complexity of this particular enzymatic system. Lar activity is associated with LarA and its nickel-containing cofactor, synthesized from nicotinic acid adenine dinucleotide by the three biosynthetic enzymes: LarB, LarC, and LarE...
August 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28819296/intravoxel-incoherent-motion-diffusion-weighted-imaging-for-discriminating-the-pathological-response-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#10
Wen Lu, Hou Jing, Zhou Ju-Mei, Nie Shao-Lin, Cao Fang, Yu Xiao-Ping, Lu Qiang, Zeng Biao, Zhu Su-Yu, Hu Ying
To investigate the usefulness of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in discriminating the pathological complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC), 42 patients underwent preoperative IVIM-DWI before (pre-nCRT) and after nCRT (post-nCRT). The values of pre-nCRT and post-nCRT IVIM-DWI parameters (ADC, D, D* and f), together with the percentage changes (∆% parametric value) induced by nCRT, were compared between the pCR (tumour regression grade [TRG] 4) and non-pCR (TRG 0, 1, 2 or 3) groups and between the GR (TRG 3 or 4) and PR (TRG 0, 1 or 2) groups based on the Dworak TRG system...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806374/long-acting-reversible-contraception-among-homeless-women-veterans-with-chronic-health-conditions-a-retrospective-cohort-study
#11
Lori M Gawron, Andrew Redd, Ying Suo, Warren Pettey, David K Turok, Adi V Gundlapalli
BACKGROUND: US women Veterans are at increased risk of homelessness and chronic health conditions associated with unintended pregnancy. Veterans Health Administration (VHA) provision of long-acting reversible contraception (LARC) can assist in healthy pregnancy planning. OBJECTIVES: To evaluate perinatal risk factors and LARC exposure in ever-homeless women Veterans. RESEARCH DESIGN: A retrospective cohort study of women Veterans using VHA administrative data from fiscal years 2002-2015...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28803718/total-neoadjuvant-therapy-a-shifting-paradigm-in-locally-advanced-rectal-cancer-management
#12
REVIEW
Aaron J Franke, Hiral Parekh, Jason S Starr, Sanda A Tan, Atif Iqbal, Thomas J George
Colorectal carcinoma is the second leading cause of cancer-related deaths in the United States, with rectal cancer accounting for approximately one-third of newly diagnosed cases, thus representing a major socioeconomic health burden. Although minimally invasive procedures (ie, transanal excision) may be appropriate for a subset of patients with small, superficially invasive tumors, a more comprehensive trimodality approach with neoadjuvant chemoradiotherapy, total mesorectal excision, and systemic chemotherapy is recommended for medically operable patients with nonmetastatic, locally advanced rectal cancer (LARC)...
June 27, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28801054/-without-bodily-autonomy-we-are-not-free-exploring-women-s-concerns-about-future-access-to-contraception-following-the-2016-us-presidential-election
#13
Colleen P Judge, Tierney E Wolgemuth, Megan E Hamm, Sonya Borrero
OBJECTIVE: Following the 2016US presidential election, social media posts and news stories amplified concerns about the potential for reduced access to contraception under the incoming administration and urged women to seek long-acting reversible contraception. We aimed to describe women's concerns about future access to contraception, in their own words. STUDY DESIGN: A social-media-based, anonymous online survey assessing thoughts and concerns about future access to contraception was distributed to reproductive-aged US women for 1 week in mid-January 2017...
August 8, 2017: Contraception
https://www.readbyqxmd.com/read/28795311/the-rise-of-female-sterilization-a-closer-look-at-colombia
#14
Beatriz M Folch, Sarah Betstadt, Dongmei Li, Natalie Whaley
Objective In the 1970s, OCPs and IUDs were the most popular contraceptive methods in Colombia. According to data from the most recent Demographic and Health Survey (DHS), sterilization has become the most common form of birth control in Colombia. This study aims to examine the characteristics of Colombian women desiring long-acting contraception. Methods This study uses the 2005 and 2010 Colombian DHS dataset. Women who choose long-acting contraception were divided into those using female sterilization and those using long-acting reversible contraception (LARC)...
August 9, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28756039/muscle-wasting-and-survival-following-pre-operative-chemoradiotherapy-for-locally-advanced-rectal-carcinoma
#15
S Levolger, M G van Vledder, W J Alberda, C Verhoef, R W F de Bruin, J N M IJzermans, J W Burger
BACKGROUND & AIMS: Neoadjuvant chemoradiotherapy (NACRT) has increased local control in locally advanced rectal cancer. Reduced skeletal muscle mass (sarcopenia), or ongoing muscle wasting, is associated with decreased survival in cancer. This study aims to assess the change in body composition during NACRT and its impact on outcome using computed tomography (CT) imaging in locally advanced rectal cancer (LARC) patients. METHODS: LARC patients treated with NACRT were selected from a prospectively maintained database and retrospectively analyzed...
July 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28740922/serum-lipidomic-study-reveals-potential-early-biomarkers-for-predicting-response-to-chemoradiation-therapy-in-advanced-rectal-cancer-a-pilot-study
#16
Piero Del Boccio, Francesca Perrotti, Claudia Rossi, Ilaria Cicalini, Sara Di Santo, Mirco Zucchelli, Paolo Sacchetta, Domenico Genovesi, Damiana Pieragostino
PURPOSE: Prospective detection of patients with advanced rectal cancer (LARC) who have a higher probability of responding to preoperative chemoradiotherapy (CRT) may provide individualized therapy. Lipidomics is an emerging science dedicated to the characterization of lipid fingerprint involved in different pato-physiological conditions. The purpose of this study is to highlight a typical lipid signature able to predict the tumor response to CRT. EXPERIMENTAL DESIGN: A prospective global analysis of lipids in 54 sera from 18 LARC patients treated with preoperative CRT was performed...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28732671/psoas-hitch-ureteral-reimplantation-after-surgery-for-locally-advanced-and-locally-recurrent-colorectal-cancer-complications-and-oncological-outcome
#17
F van den Heijkant, T A Vermeer, E J E J Vrijhof, G A P Nieuwenhuijzen, E L Koldewijn, H J T Rutten
INTRODUCTION: The most important prognostic factor for oncological outcome of rectal cancer is radical surgical resection. In patients with locally advanced T4 rectal cancer (LARC) or locally recurrent rectal cancer (LRRC) (partial) resection of the urinary tract is frequently required to achieve radical resection. The psoas bladder hitch (PBH) technique is the first choice for reconstruction of the ureter after partial resection and this bladder-preserving technique should not influence the oncological outcome...
May 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28721901/psmb8-as-a-candidate-marker-of-responsiveness-to-preoperative-radiation-therapy-in-rectal-cancer-patients
#18
Ye Jin Ha, Ka Hee Tak, Chan Wook Kim, Seon Ae Roh, Eun Kyung Choi, Dong Hyung Cho, Jeong Hwan Kim, Seon Kyu Kim, Seon Young Kim, Yong Sung Kim, Jin Cheon Kim
PURPOSE: The ability to predict individual responsiveness to cancer therapy is urgently needed. This is particularly true for patients with locally advanced rectal cancer (LARC) because a large proportion are resistant to preoperative chemoradiation therapy (CRT). In this study, we sought to identify markers that could predict response by comparing the gene expression profiles of the tumors of patients who received preoperative CRT. METHODS AND MATERIALS: The basal gene expression profiles of tumors from 22 LARC patients who were responders (n=9) and nonresponders (n=13) to preoperative CRT were analyzed using RNA sequencing (RNA-Seq)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28697112/contraception-after-delivery-among-publicly-insured-women-in-texas-use-compared-with-preference
#19
Joseph E Potter, Kate Coleman-Minahan, Kari White, Daniel A Powers, Chloe Dillaway, Amanda J Stevenson, Kristine Hopkins, Daniel Grossman
OBJECTIVE: To assess women's preferences for contraception after delivery and to compare use with preferences. METHODS: In a prospective cohort study of women aged 18-44 years who wanted to delay childbearing for at least 2 years, we interviewed 1,700 participants from eight hospitals in Texas immediately postpartum and at 3 and 6 months after delivery. At 3 months, we assessed contraceptive preferences by asking what method women would like to be using at 6 months...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28693154/association-between-the-expression-of-micrornas-and-the-response-of-patients-with-locally-advanced-rectal-cancer-to-preoperative-chemoradiotherapy
#20
Anne Haahr Mellergaard Eriksen, Flemming Brandt Sørensen, Rikke Fredslund Andersen, Anders Jakobsen, Torben Frøstrup Hansen
Preoperative chemoradiotherapy (CRT) followed by mesorectal excision is the standard treatment for patients with locally advanced rectal cancer (LARC). The balance between treatment efficacy and toxicity is a major issue in the clinical management of these patients. There is a requirement for the identification of predictive molecular biomarkers for the response of patients to CRT. The present study aimed to analyze the association between microRNA (miRNA/miR) expression and treatment efficacy in patients with LARC who were treated with preoperative CRT...
July 2017: Oncology Letters
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