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https://www.readbyqxmd.com/read/27903078/why-prevention-of-repeat-abortion-is-so-challenging-psychosocial-characteristics-of-women-at-risk
#1
Brigitte Leeners, Simone Bieli, Dorothy Huang, Sibil Tschudin
OBJECTIVES: Abortion rates have declined in recent decades; however, the rate of repeat abortion remains high. In order to identify keys to making efficient interventions against repeat abortion, our objectives were: to assess the percentage of repeat abortions in women opting for termination of pregnancy over a period of 1 year; to identify the risk factors for repeat abortion; and to assess the characteristics of women who opted for a further pregnancy termination despite having received standard post-abortion care...
November 30, 2016: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/27891147/effect-of-neoadjuvant-chemoradiotherapy-with-capecitabine-versus-fluorouracil-for-locally-advanced-rectal-cancer-a-meta-analysis
#2
REVIEW
Guo-Chen Liu, Jun-Ping Yan, Qing He, Xin An, Zhi-Zhong Pan, Pei-Rong Ding
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27886277/a-retrospective-analysis-on-two-week-short-course-pre-operative-radiotherapy-in-elderly-patients-with-resectable-locally-advanced-rectal-cancer
#3
Chen Shi, Hao Zhou, Xiaofan Li, Yong Cai
To validate that a two-week short-course pre-operative radiotherapy regimen is feasible, safe, and effective for the management of elderly patients with locally advanced rectal cancer (LARC), we retrospectively analyzed 99 radiotherapy-naive patients ≥70 years of age with LARC. Patients received pelvic radiation therapy (3D-CRT 30Gy/10f/2w) followed by TME surgery; some patients received adjuvant chemotherapy. The primary endpoint was OS, while the secondary endpoints were DFS, safety and response rate. The median follow-up time was 5...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884730/a-qualitative-application-of-diffusion-of-innovations-to-adolescents-perceptions-of-long-acting-reversible-contraception-s-attributes
#4
Molly K Murphy, Pamela J Burke, Sadia Haider
BACKGROUND: Long-acting reversible contraceptive (LARC) methods are the most effective forms of reversible contraception but adolescents often opt for other, less effective methods. This study explored how adolescents viewed LARC as an innovation to be adopted or rejected, and how their assessment of innovation attributes impacted their decisions about LARC. MATERIALS AND METHODS: Sexually active adolescents between 15-22 years old (n=22) participated in semi-structured qualitative interviews...
November 21, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27879980/theory-based-interventions-for-contraception
#5
REVIEW
Laureen M Lopez, Thomas W Grey, Mario Chen, Elizabeth E Tolley, Laurie L Stockton
BACKGROUND: The explicit use of theory in research helps expand the knowledge base. Theories and models have been used extensively in HIV-prevention research and in interventions for preventing sexually transmitted infections (STIs). The health behavior field uses many theories or models of change. However, many educational interventions addressing contraception have no explicit theoretical base. OBJECTIVES: To review randomized controlled trials (RCTs) that tested a theoretical approach to inform contraceptive choice and encourage or improve contraceptive use...
November 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27871920/integrating-long-acting-reversible-contraception-larc-services-into-new-york-city-school-based-health-centers-sbhcs-quality-improvement-to-ensure-provision-of-youth-friendly-services
#6
Manaswi Sangraula, Samantha Garbers, Janet Garth, Emily Birchfield Shakibnia, Sarah Timmons, Melanie A Gold
STUDY OBJECTIVE: Adolescents face barriers to accessing youth-friendly family planning services, specifically long-acting reversible contraception (LARC). School-Based Health Centers (SBHCs) can provide youth-friendly care. A quality improvement (QI) project was undertaken to assess quality of care before, during and after LARC services at three SBHCs, and to identify specific strategies for improving these LARC services. METHODS: We interviewed 18 female adolescents who received LARC services...
November 18, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27871919/motivational-interviewing-to-promote-long-acting-reversible-contraception-in-postpartum-teenagers
#7
Kristl Tomlin, Tammalynn Bambulas, Maureen Sutton, Vanessa Pazdernik, Dean V Coonrod
STUDY OBJECTIVE: To determine if teenage patients receiving prenatal care in an adolescent-focused clinic, emphasizing Long-acting Reversible Contraception (LARC) using motivational interviewing techniques, had higher rates of uptake of postpartum LARC than a control group. DESIGN: Retrospective cohort study comparing young women who received prenatal care in an adolescent-focused setting and those enrolled in Standard Prenatal Care. PARTICIPANTS: Adolescents between the ages of 13 and 17 receiving prenatal care within the Maricopa Integrated Health safety-net system between 2007 and 2014...
November 18, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27855100/increasing-the-uptake-of-long-acting-reversible-contraception-in-general-practice-the-australian-contraceptive-choice-project-accord-cluster-randomised-controlled-trial-protocol
#8
Danielle Mazza, Kirsten Black, Angela Taft, Jayne Lucke, Kevin McGeechan, Marion Haas, Heather McKay, Jeffery F Peipert
INTRODUCTION: The increased use of long-acting reversible contraceptives (LARCs), such as intrauterine devices and hormonal implants, has the potential to reduce unintended pregnancy and abortion rates. However, use of LARCs in Australia is very low, despite clinical practice guidance and statements by national and international peak bodies advocating their increased use. This protocol paper describes the Australian Contraceptive ChOice pRojet (ACCORd), a cluster randomised control trial that aims to test whether an educational intervention targeting general practitioners (GPs) and establishing a rapid referral service are a cost-effective means of increasing LARC uptake...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27845363/discriminating-cancer-related-and-cancer-unrelated-chemoradiation-response-genes-for-locally-advanced-rectal-cancers
#9
You Guo, Jun Cheng, Lu Ao, Xiangyu Li, Qingzhou Guan, Juan Zhang, Haidan Yan, Hao Cai, Qiao Gao, Weizhong Jiang, Zheng Guo
For patients with locally advanced rectal cancer (LARC) treated with preoperation chemoradiation (pCRT), identifying differentially expressed (DE) genes between non-responders and responders is a common approach for investigating mechanisms of chemoradiation resistance. However, some of such DE genes might be irrelevant to cancer itself but simply reflect the pharmacokinetic differences of the normal tissues. In this study, we adopted the RankComp algorithm to identify DE genes for each of LARC sample compared with its own normal state...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832675/adolescent-contraception-before-and-after-pregnancy-choices-and-challenges-for-the-future
#10
Anderson Borovac-Pinheiro, Fernanda Garanhani Surita, Aline D'Annibale, Rodolfo de Carvalho Pacagnella, Joao Luiz Pinto E Silva
Objective To determine methods of contraception used by adolescents before and after pregnancy. Methods A cross-sectional study was performed, and data were collected from medical records of all teens in puerperal consultation at the Hospital da Mulher - José Aristodemo Pinotti (Caism), Universidade Estadual de Campinas (CAISM), São Paulo, Brazil, between July 2011 and September 2013. The inclusion criterion was being 10 to 19 years old, and the exclusion criterion was having a first consultation 90 days after childbirth...
November 10, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27825672/survival-impact-of-adjuvant-chemotherapy-for-resected-locally-advanced-rectal-adenocarcinoma
#11
Rebecca Y Tay, Murtaza Jamnagerwalla, Malcolm Steel, Hui-Li Wong, Joseph J McKendrick, Ian Faragher, Suzanne Kosmider, Ian Hastie, Jayesh Desai, Mark Tacey, Peter Gibbs, Rachel Wong
BACKGROUND: Recent data has created uncertainty regarding the benefit of adjuvant fluoropyrimidine-containing chemotherapy following preoperative chemoradiotherapy and surgical resection for locally advanced rectal cancer (LARC). In particular, patients with a pathologic complete response (pCR) may derive no benefit from adjuvant chemotherapy. PATIENTS AND METHODS: This is a retrospective analysis of patients with LARC, diagnosed between January 1, 2003 and December 31, 2014 at 3 Melbourne health services...
October 6, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27805934/straight-talk-about-birth-control-a-contraceptive-education-protocol-for-home-care
#12
Leslie Schoenberg
Home healthcare providers play a critical role in the prevention of unintended pregnancies by providing evidence-based contraception education during home visits. This article describes an innovative and comprehensive contraception protocol that was developed for Nurse-Family Partnership to improve contraception education for home healthcare patients. The protocol focused on increasing uptake of long-acting reversible contraception (LARC) for high-risk prenatal and postpartum home healthcare patients. The protocol was designed to reduce early subsequent pregnancies and thereby improve outcomes for mothers and their infants...
November 2016: Home Healthcare Now
https://www.readbyqxmd.com/read/27793945/a-comparative-effectiveness-study-of-two-oral-chemotherapy-drugs-uft-vs-capecitabine-in-neoadjuvant-concurrent-chemoradiotherapy-for-patients-with-locally-advanced-rectal-cancer
#13
Chun-Ru Chien, William Tzu-Liang Chen, Hwei-Min Wang, Tao-Wei Ke, Hua-Che Chiang, Sheng-Chi Chang, Yu-Chun Huang, Che-Hung Lin, Chun-Lin Huang, Ying-Chun Lin, Tsung-Wei Chen, Chia-Chin Li, K S Clifford Chao
BACKGROUND/AIM: Capecitabine is the current standard oral chemotherapy used in neoadjuvant concurrent chemoradiotherapy (NCCRT) for locally advanced rectal cancer (LARC) in North America. We compared the effectiveness of another oral chemotherapy agent, UFT (an oral combination of uracil and tegafur), to that of capecitabine. MATERIALS AND METHODS: We identified LARC patients diagnosed from 2007 to 2011 using a population-based registry in Taiwan (Health and Welfare Data Science Center, HWDC) and constructed a propensity score matched cohort to balance observable potential confounders...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27785074/locally-advanced-rectal-cancer-management-challenges
#14
REVIEW
R F Kokelaar, M D Evans, M Davies, D A Harris, J Beynon
Between 5% and 10% of patients with rectal cancer present with locally advanced rectal cancer (LARC), and 10% of rectal cancers recur after surgery, of which half are limited to locoregional disease only (locally recurrent rectal cancer). Exenterative surgery offers the best long-term outcomes for patients with LARC and locally recurrent rectal cancer so long as a complete (R0) resection is achieved. Accurate preoperative multimodal staging is crucial in assessing the potential operability of advanced rectal tumors, and resectability may be enhanced with neoadjuvant therapies...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27784279/developmental-transcriptome-of-resting-cell-formation-in-mycobacterium-smegmatis
#15
Mu-Lu Wu, Martin Gengenbacher, Jade C S Chung, Swaine Lin Chen, Hans-Joachim Mollenkopf, Stefan H E Kaufmann, Thomas Dick
BACKGROUND: Mycobacteria, along with exospore forming Streptomyces, belong to the phylum actinobacteria. Mycobacteria are generally believed to be non-differentiating. Recently however, we showed that the mycobacterial model organism M. smegmatis is capable of forming different types of morphologically distinct resting cells. When subjected to starvation conditions, cells of M. smegmatis exit from the canonical cell division cycle, segregate and compact their chromosomes, and become septated and multi-nucleoided...
October 26, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27773708/the-impact-of-an-iud-and-implant-intervention-on-dual-method-use-among-young-women-results-from-a-cluster-randomized-trial
#16
Alison M El Ayadi, Corinne H Rocca, Julia E Kohn, Denisse Velazquez, Maya Blum, Sara J Newmann, Cynthia C Harper
Long-acting reversible contraceptives (LARCs) are highly effective at preventing pregnancy but do not protect against sexually transmitted infection (STI). Recent efforts to improve access to intrauterine devices (IUDs) and implants have raised concerns about STI prevention and reduced condom use, particularly among teenagers and young women. We evaluated whether a provider-targeted intervention to increase LARC access negatively impacted dual method use and STI incidence among an at-risk patient population...
October 20, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27770484/medical-therapies-for-heavy-menstrual-bleeding-in-women-with-uterine-fibroids-a-retrospective-analysis-of-a-large-commercially-insured-population-in-the-usa
#17
X Yao, E A Stewart, S K Laughlin-Tommaso, H C Heien, B J Borah
OBJECTIVES: To report patterns and patient characteristics associated with initiation of and persistence with medical therapies for uterine fibroid-related heavy menstrual bleeding. DESIGN: Retrospective cohort study. SETTING: US commercial insurance claims database. POPULATION: 41 561 women aged 18-54 years with uterine fibroids and heavy menstrual bleeding who initiated medical therapies from January 2000 through December 2013...
October 21, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27766561/deep-pelvic-surgical-site-infection-after-radiotherapy-and-surgery-for-locally-advanced-rectal-cancer
#18
E B Thorgersen, M A Goscinski, M Spasojevic, A M Solbakken, A B Mariathasan, K Boye, S G Larsen, K Flatmark
BACKGROUND: High morbidity, increased mortality, and impaired long-term oncologic outcome have been reported after deep surgical site infection (SSI) in rectal cancer surgery. The rate, risk factors and consequences of deep SSI after (chemo)radiotherapy [(C)RT], and surgery for locally advanced rectal cancer (LARC) in a tertiary university hospital single centre cohort of 540 patients are presented. METHODS: Patients with LARC, operated between January 1, 2007 and December 31, 2015, were identified in the institutional prospective database...
October 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27753522/are-health-plan-design-and-prior-use-of-long-acting-reversible-contraception-associated-with-pregnancy-intention
#19
Mary Anne Armstrong, Debbie A Postlethwaite, Jeanne A Darbinian, Mark McCoy, Amy Law
BACKGROUND: In 2007, high-deductible plans were added to the primarily nondeductible Kaiser Permanente Northern California (KPNC) integrated health plan, which had covered 100% of device and procedure costs of long-acting reversible contraception (LARC) for members regardless of prescription/visit copay amount. We hypothesized that nondeductible plans and prior LARC use decreased unintended pregnancy. OBJECTIVE: The purpose of this study was to determine if health plan design (nondeductible vs...
October 18, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27749573/definitive-high-dose-radiotherapy-with-concurrent-chemotherapy-for-locally-advanced-rectal-cancer-a-case-report-and-literature-review
#20
Min-Jeong Kim, Eun Seok Kim, Seung-Gu Yeo
BACKGROUND: Standard management for locally advanced rectal cancer (LARC) involves preoperative chemoradiotherapy (CRT) and radical surgery. However, this level of treatment may be unnecessary for a subgroup of LARC patients. Previous reports have shown that approximately 20% of LARC patients experience a complete tumor response to preoperative CRT. Post-CRT nonoperative management of these patients may prevent morbidities associated with radical surgery. To our knowledge, this case report firstly presents the favorable long-term outcomes of a LARC patient who underwent definitive aim CRT...
October 2016: Medicine (Baltimore)
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