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https://www.readbyqxmd.com/read/28194687/fecal-incontinence-and-radiation-dose-on-anal-sphincter-in-patients-with-locally-advanced-rectal-cancer-larc-treated-with-preoperative-chemoradiotherapy-a-retrospective-single-institutional-study
#1
F Arias, C Eito, G Asín, I Mora, K Cambra, F Mañeru, B Ibáñez, L Arbea, A Viudez, I Hernández, J I Arrarás, M Errasti, M Barrado, M Campo, I Visus, S Flamarique, M A Ciga
BACKGROUND: The objective of the study is to determine the correlations among the variables of dose and the sphincter function (SF) in patients with locally advanced rectal cancer treated with preoperative capecitabine/radiotherapy followed by low anterior resection (LAR) + TME. METHODS: We retrospectively reviewed 92 consecutive patients with LARC treated at our center with LAR from 2006 and more than 2 years free from disease. We re-contoured the anal sphincters (AS) of patients with the help of the radiologist...
February 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28193721/women-s-limited-choice-and-availability-of-modern-contraception-at-retail-outlets-and-public-sector-facilities-in-luanda-angola-2012-2015
#2
Benjamin Nieto-Andrade, Eva Fidel, Rebecca Simmons, Dana Sievers, Anya Fedorova, Suzanne Bell, Karen Weidert, Ndola Prata
In Angola, many women want to use family planning but lack access to affordable and preferred methods. This article assesses the link between women's choice and availability of contraceptive methods in Luanda, Angola, drawing on data from 3 surveys: a 2012 survey among women ages 15-49 and 2 retail surveys conducted in 2014 and 2015 among outlets and facilities offering contraceptive methods. Descriptive statistics for women's contraceptive knowledge, use, and preferred methods were stratified by age group...
February 13, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28159930/compared-planning-dosimetry-of-tomo-vmat-and-imrt-in-rectal-cancer-with-different-simulated-positions
#3
Jang-Chun Lin, Jo-Ting Tsai, Li-Jhen Chen, Ming-Hsien Li, Wei-Hsiu Liu
OBJECTIVES: To compare treatment plans for helical tomotherapy (TOMO), volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for locally advanced rectal cancer (LARC). MATERIALS AND METHODS: This retrospective study from December 2010 to June 2013 included 20 patients with LARC who received neoadjuvant concurrent chemoradiotherapy (CCRT) with radiation doses of greater than 50.4 Gy. Dosimetric quality was evaluated based on doses to organs at risk (OARs), including small bowel, urinary bladder and bilateral femoral head, over the same coverage of the clinical target volume (CTV)...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28159123/who-uses-long-acting-reversible-contraception-profile-of-larc-users-in-the-cupid-cohort
#4
Jacqueline Coombe, Melissa L Harris, Deborah Loxton
OBJECTIVE: To explore the characteristics of long-acting reversible contraception (LARC) users in a nationally representative cohort of young Australian women aged 18-23. METHODS: Data from 3155 women who responded to a question about their contraceptive use in the previous six months at the baseline Contraceptive Use, Pregnancy Intention and Decisions (CUPID) survey were included. RESULTS: 726 (19.1%) women reported LARC use, with the Implanon being the most popular method (n = 478; 65...
March 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28138443/local-advanced-rectal-cancer-perforation-in-the-midst-of-preoperative-chemoradiotherapy-a-case-report-and-literature-review
#5
Nobuhisa Takase, Kimihiro Yamashita, Yasuo Sumi, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yu-Ichiro Koma, Masato Komatsu, Ryohei Sasaki, Yoshihiro Kakeji
Standard chemoradiotherapy (CRT) for local advanced rectal cancer (LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever...
January 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28123724/clinical-implications-of-preoperative-chemoradiotherapy-prior-to-laparoscopic-surgery-for-locally-advanced-low-rectal-cancer
#6
Keisaku Kondo, Taiju Shimbo, Keitaro Tanaka, Masashi Yamamoto, Yoshifumi Narumi, Junji Okuda, Kazuhisa Uchiyama
The present study aimed to evaluate whether preoperative chemoradiotherapy (CRT) has any adverse effects on laparoscopic surgery (LS) for locally advanced low rectal cancer (LARC). The study was performed at the Osaka Medical College Hospital, and included patients who were operated on between July 2006 and December 2013. The short-term outcomes in 156 patients who underwent surgery for LARC following CRT were evaluated, of whom 152 underwent LS. Among the patients who were followed for >40 months, 77 patients (the CRT group) were compared with 39 patients who underwent LS without CRT (the surgery-alone group) for long-term outcomes...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28121581/effect-of-removing-financial-barriers-on-use-of-long-acting-reversible-contraceptives
#7
Jack Mccain
Long-lasting reversible contraceptives (LARCs) are easy to use and effective. One reason the U.S. lags behind other developed countries in LARC use is that memories of the Dalkon Shield still linger from the 1970s, when a design defect in that IUD resulted in infections that led to infertility, ectopic pregnancies, and death.
August 2016: Managed Care
https://www.readbyqxmd.com/read/28119863/prognostic-impact-of-immunonutritional-status-changes-during-preoperative-chemoradiation-in-patients-with-rectal-cancer
#8
Yong Joon Lee, Woo Ram Kim, Jeonghee Han, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
PURPOSE: Previous studies have demonstrated the prognostic impact of the prognostic nutritional index (PNI), a proposed indicator of immunonutritional statuses of surgical patients, on patients with various gastrointestinal cancers. Although the prognostic impact of the PNI on patients with colorectal cancer has been well established, its value has not been studied in patients treated with preoperative chemoradiation (pCRT). This study aimed to evaluate the prognostic impact of PNI on patients receiving pCRT for locally advanced rectal cancer (LARC)...
December 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/28110980/female-sterilization-is-more-common-among-women-with-physical-and-or-sensory-disabilities-than-women-without-disabilities-in-the-united-states
#9
Justine P Wu, Michael M McKee, Kimberly S Mckee, Michelle A Meade, Melissa Plegue, Ananda Sen
BACKGROUND: Female sterilization accounts for 50% of all contraceptive use in the U.S. The extent to which U.S. women with physical and/or sensory disabilities have undergone female sterilization is unknown. OBJECTIVE: Our primary objective was to determine the prevalence of sterilization for women with physical/sensory disabilities, and compare this to the prevalence for women without disabilities. We also compared use of long-acting reversible contraceptive (LARC) methods between women with and without disabilities...
January 3, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28105657/a-nomogram-to-predict-distant-metastasis-after-neoadjuvant-chemoradiotherapy-and-radical-surgery-in-patients-with-locally-advanced-rectal-cancer
#10
Yanwu Sun, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
PURPOSE: To compare distant metastasis (DM) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery alone, and to develop a predictive nomogram for DM following nCRT. METHODS: Propensity-scoring match analysis was performed to compare DM in LARC treated with nCRT (n = 375) and surgery alone (n = 375). Cox regression was performed to identify predictors of DM following nCRT. A nomogram was developed and validated by internal (n = 425) and external validation (n = 97)...
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28100902/prognostic-role-of-neutrophil-to-lymphocyte-ratio-in-locally-advanced-rectal-cancer-treated-with-neoadjuvant-chemoradiotherapy
#11
Jinwen Shen, Yuan Zhu, Wei Wu, Lingnan Zhang, Haixing Ju, Yongtian Fan, Yuping Zhu, Jialin Luo, Peng Liu, Ning Zhou, Ke Lu, Na Zhang, Dechuan Li, Luying Liu
BACKGROUND Increasing evidence suggests that cancer-associated inflammation is associated with poorer outcomes. The neutrophil-to-lymphocyte ratio (NLR), considered as a systemic inflammation marker, is thought to predict prognoses in colorectal cancer. In this study, we explored the association between the NLR and prognoses following neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). MATERIAL AND METHODS From February 2002 to December 2012, a group of 202 patients diagnosed with LARC and receiving neoadjuvant CRT followed by radical surgery was included in our retrospective study...
January 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28088438/a-snapshot-of-urban-adolescent-women-s-contraceptive-knowledge-at-the-onset-of-a-community-larc-promotion-initiative
#12
K B Greenberg, S C Jenks, N G Piazza, B R Malibiran, C A Aligne
STUDY OBJECTIVE: To contextualize young women's knowledge and attitudes regarding contraception at the outset of an intervention promoting long-acting reversible contraceptives (LARC) for teen pregnancy prevention. DESIGN: and Setting: Our intervention is based on diffusion of innovation theory, and at the outset we were interested in likely early adopters' existing knowledge and attitudes towards contraception. This mixed methods study consists of focus groups within positive youth development programs in Rochester, New York; we discussed young women's knowledge and sources of information for all FDA-approved contraceptive methods...
January 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28068245/ku70-ku80-and-sclusterin-a-cluster-of-predicting-factors-for-response-to-neoadjuvant-chemoradiation-therapy-in-patients-with-locally-advanced-rectal-cancer
#13
Sabina Pucci, Chiara Polidoro, Alessandro Joubert, Francesca Mastrangeli, Barbara Tolu, Michaela Benassi, Valeria Fiaschetti, Laura Greco, Roberto Miceli, Roberto Floris, Giuseppe Novelli, Augusto Orlandi, Riccardo Santoni
PURPOSE: The identification of predictive biomarkers for neoadjuvant chemoradiation therapy (CRT) is a current clinical need. The heterodimer Ku70/80 plays a critical role in DNA repair and cell death induction after damage. The aberrant expression and localization of these proteins fail to control DNA repair and apoptosis. sClusterin is the Ku70 partner that sterically inhibits Bax-dependent cell death after damage in some pathologic conditions. This study sought to evaluate the molecular relevance of Ku70-Ku80-Clu as a molecular cluster predicting the response to neoadjuvant CRT in patients with locally advanced rectal cancer (LARC)...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28063850/patient-education-about-the-affordable-care-act-contraceptive-coverage-requirement-increases-interest-in-using-long-acting-reversible-contraception
#14
Julia C Durante, Elisabeth J Woodhams
BACKGROUND: The Patient Protection and Affordable Care Act (ACA) requires health insurance to cover all Food and Drug Administration-approved contraceptives at no cost to patients, including highly effective long-acting reversible contraception (LARC). Our objective was to determine whether a brief educational intervention about these provisions would increase interest in LARC use. METHODS: This is a cross-sectional survey of women seeking contraceptive care in an urban outpatient obstetrics/gynecology clinic...
January 4, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28060889/sequential-pet-ct-with-18f-fdg-predicts-pathological-tumor-response-to-preoperative-short-course-radiotherapy-with-delayed-surgery-in-patients-with-locally-advanced-rectal-cancer-using-logistic-regression-analysis
#15
Biagio Pecori, Secondo Lastoria, Corradina Caracò, Marco Celentani, Fabiana Tatangelo, Antonio Avallone, Daniela Rega, Giampaolo De Palma, Maria Mormile, Alfredo Budillon, Paolo Muto, Francesco Bianco, Luigi Aloj, Antonella Petrillo, Paolo Delrio
: Previous studies indicate that FDG PET/CT may predict pathological response in patients undergoing neoadjuvant chemo-radiotherapy for locally advanced rectal cancer (LARC). Aim of the current study is evaluate if pathological response can be similarly predicted in LARC patients after short course radiation therapy alone. METHODS: Thirty-three patients with cT2-3, N0-2, M0 rectal adenocarcinoma treated with hypo fractionated short course neoadjuvant RT (5x5 Gy) with delayed surgery (SCRTDS) were prospectively studied...
2017: PloS One
https://www.readbyqxmd.com/read/28047611/su-f-r-48-early-prediction-of-pathological-response-of-locally-advanced-rectal-cancer-using-perfusion-ct-a-prospective-clinical-study
#16
K Nie, L Shi, N Yue, S Jabbour, S Kim, T Mao, L Qian, X Hu, X Sun, T Niu
PURPOSE: To prospectively evaluate the tumor vascularity assessed by perfusion CT for prediction of chemo-radiation treatment (CRT) response in locally advanced rectal cancer (LARC). METHODS: Eighteen consecutive patients (61.9±8.8 years, from March-June 2015) diagnosed with LARC who underwent 6-8 weeks CRT followed by surgery were included. The pre-treatment perfusion CT was acquired after a 5s delay of contrast agent injection for 45s with 1s interval. A total of 7-cm craniocaudal range covered the tumor region with 3-mm slice thickness...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042958/standardized-index-of-shape-dce-mri-and-standardized-uptake-value-pet-ct-two-quantitative-approaches-to-discriminate-chemo-radiotherapy-locally-advanced-rectal-cancer-responders-under-a-functional-profile
#17
Antonella Petrillo, Roberta Fusco, Mario Petrillo, Vincenza Granata, Paolo Delrio, Francesco Bianco, Biagio Pecori, Gerardo Botti, Fabiana Tatangelo, Corradina Caracò, Luigi Aloj, Antonio Avallone, Secondo Lastoria
PURPOSE: To investigate dynamic contrast enhanced-MRI (DCE-MRI) in the preoperative chemo-radiotherapy (CRT) assessment for locally advanced rectal cancer (LARC) compared to18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). METHODS: 75 consecutive patients with LARC were enrolled in a prospective study. DCE-MRI analysis was performed measuring SIS: linear combination of percentage change (Δ) of maximum signal difference (MSD) and wash-out slope (WOS)...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28041992/changes-in-body-composition-in-women-using-long-acting-reversible-contraception
#18
Priscilla de Nazaré Silva Dos Santos, Tessa Madden, Karen Omvig, Jeffrey F Peipert
OBJECTIVE: Users of hormonal long-acting reversible contraception (LARC) report weight gain as a side effect, but few studies have assessed body composition change among LARC users. We evaluated weight and body composition of healthy women using the levonorgestrel intrauterine system (LNG-IUS), copper intrauterine device (copper IUD) or etonogestrel implant (ENG implant). We hypothesized that weight gain and body composition over 12 months would not differ between copper IUD, LNG-IUS and ENG implant users...
December 30, 2016: Contraception
https://www.readbyqxmd.com/read/28038902/long-acting-reversible-contraception-in%C3%A2-adolescents-a-systematic-review-and%C3%A2-meta-analysis
#19
REVIEW
Justin T Diedrich, David A Klein, Jeffrey F Peipert
OBJECTIVE: We sought to perform a systematic review of the medical literature to assess the continuation of long-acting reversible contraceptives among adolescents. STUDY DESIGN: Ovid-MEDLINE, Cochrane databases, and Embase databases were searched using key words relevant to the provision of long-acting contraception to adolescents. Articles published from January 2002 through August 2016 were selected for inclusion based on specific key word searches and detailed review of bibliographies...
December 28, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28025660/low-amplitude-rhythmic-contraction-frequency-in-human-detrusor-strips-correlates-with-phasic-intravesical-pressure-waves
#20
Andrew F Colhoun, John E Speich, Lauren F Cooley, Eugene D Bell, R Wayne Barbee, Georgi Guruli, Paul H Ratz, Adam P Klausner
PURPOSE: Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate with in vivo LARC frequencies, visualized as phasic intravesical pressure (p ves) waves during urodynamics (UD). METHODS: After IRB approval, fresh strips of human urinary bladder were obtained from patients...
December 26, 2016: World Journal of Urology
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