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https://www.readbyqxmd.com/read/28314318/systemic-inflammatory-response-after-preoperative-chemoradiotherapy-can-affect-oncologic-outcomes-in-locally-advanced-rectal-cancer
#1
In Hee Lee, Soyoon Hwang, Soo Jung Lee, Byung Woog Kang, Dongwon Baek, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu Seog Choi, Jae Chul Kim, Seung Hyun Cho, Jong Gwang Kim
AIM: Systemic inflammatory response (SIR) has been reported to be an important determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC)...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28314302/kras-mutant-status-may-be-associated-with-distant-recurrence-in-early-stage-rectal-cancer
#2
Michail Sideris, Jane Moorhead, Salvador Diaz-Cano, Amyn Haji, Savvas Papagrigoriadis
BACKGROUND/AIM: Total mesorectal excision combined with neo-adjuvant chemoradiotherary (CRT) and adjuvant chemotherapy, has been the standard treatment of locally advanced rectal cancer (LARC). Although TNM (Tumor, Node, Metastasis) classification for malignant Tumors is still the cornerstone in rectal cancer staging, there has been an effort to identify molecular biomarkers with additional prognostic or predictive value. MATERIALS AND METHODS: We retrospectively analyzed molecular biomarkers on prospectively collected histological specimens and clinical data from a cohort of 135 consecutive rectal cancer cases who underwent radical excision in a tertiary center between 2011-2014 (males=87, females=48, age range=22-89 years, mean=64,67 years, SD=13...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28295220/total-neoadjuvant-therapy-for-rectal-cancer-an-emerging-option
#3
REVIEW
Ethan B Ludmir, Manisha Palta, Christopher G Willett, Brian G Czito
The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for these patients. Although adjuvant chemotherapy (ChT) after neoadjuvant CRT and definitive surgery is commonly recommended, the value of adjuvant systemic therapy remains less clear. Trials evaluating adjuvant ChT for rectal cancer have been handicapped by poor compliance rates and inconsistent survival results...
March 10, 2017: Cancer
https://www.readbyqxmd.com/read/28294293/current-barriers-and-potential-strategies-to-increase-the-use-of-long-acting-reversible-contraception-larc-to-reduce-the-rate-of-unintended-pregnancies-in-australia-an-expert-roundtable-discussion
#4
Danielle Mazza, Deborah Bateson, Meredith Frearson, Philip Goldstone, Gab Kovacs, Rod Baber
BACKGROUND: Australia's abortion rates are among the highest in the developed world. Efficacy of the most commonly used form of contraception (oral contraceptives and condoms) relies on regular user compliance. Long-acting reversible contraception (LARC) virtually eradicates contraceptive failure as it is not user-dependent; however, its uptake has been low. AIM: To provide an overview of barriers to LARC use in Australia and potential strategies to overcome these barriers...
March 10, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28292451/long-acting-reversible-contraception-an-essential-guide-for-pediatric-primary-care-providers
#5
REVIEW
Suzanne Allen, Erin Barlow
Long-acting reversible contraception (LARC) methods are 20% more effective than traditional contraceptives and are recommended by the American Academy of Pediatrics and American College of Obstetrics and Gynecology as first-line contraception for adolescent girls. Large studies show that LARC use reduces unintended pregnancies, increases user satisfaction, and prolongs duration of use. This article prepares the primary care provider (PCP) with knowledge on safety, efficacy, eligibility, confidentiality, anticipatory guidance, how to find a LARC provider, and guidance on common side effects so the PCP can confidently counsel adolescent patients on LARC methods...
April 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28287679/long-acting-reversible-contraception-a-primer-for-the-primary-care-pediatrician
#6
Sabrina Fernandez
Long-acting reversible contraception (LARC) is the most effective method of preventing pregnancy in young women and adolescents. The two types of LARC methods are the intrauterine device and the implantable rod device. The success of these methods is demonstrable due to the "perfect use" and "typical use" failure rates being near identical. Pediatricians must be comfortable counseling patients, including adolescents, about LARC methods and how to access them. This primer provides some background about the types of LARC methods, details about their efficacy and side effects, and the role of the primary pediatrician...
March 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28285153/contraceptive-method-and-self-reported-hiv-status-among-women-in-malawi
#7
Jamie E Luster, Abigail Norris Turner, Duna Alkhalaileh, Maria F Gallo
OBJECTIVES: We aimed to describe contraceptive methods used by women in Malawi and determine whether contraceptive use differed by self-reported HIV status. Effective contraception is a primary method of preventing mother-to-child transmission of HIV. STUDY DESIGN: Analysis is based on 12,658 nonpregnant, sexually debuted women ages 15-49 years in the 2010 Malawi Demographic and Health Survey. Analysis was restricted to respondents with contraceptive need (i.e., fecund and did not want a child in the next 12 months) who reported their last HIV test result...
March 8, 2017: Contraception
https://www.readbyqxmd.com/read/28284931/long-acting-reversible-contraception-an-important-solution-to-reduce-unintended-pregnancy
#8
Anita L Nelson, Andrew M Kaunitz
This event was neither sponsored nor endorsed by ACOG. Despite the availability of numerous contraceptive options, almost half of all pregnancies in the United States are unintended, creating a substantial negative health and socioeconomic burden on women and their families (Online access: http://courses.elseviercme.com/acog16/656e). The most commonly used contraceptives are dependent on adherence and "perfect use" to be efficacious, while long-acting reversible contraceptives (LARCs) offer the lowest failure rates primarily because they are user-independent...
March 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28283026/preventing-recurrence-of-endometriosis-by-means-of-long-acting-progestogen-therapy-pre-empt-report-of-an-internal-pilot-multi-arm-randomised-controlled-trial-incorporating-flexible-entry-design-and-adaption-of-design-based-on-feasibility-of-recruitment
#9
Lee J Middleton, Jane P Daniels, Annalise Weckesser, Siladitya Bhattacharya
BACKGROUND: Endometriosis is associated with the growth of endometrium in ectopic sites mainly within the pelvis. This results in inflammation and scarring, causing pain and impaired quality of life. Endometriotic lesions can be excised or ablated surgically, but the risk of recurrence is high. A Heath Technology Assessment commissioning call in 2011 sought applications for trials aimed at evaluating long-term effectiveness of postoperative, long-acting, reversible contraceptives (LARCs) in preventing recurrence of endometriosis...
March 11, 2017: Trials
https://www.readbyqxmd.com/read/28277358/postabortion-contraceptive-use-and-continuation-when-long-acting-reversible-contraception-is-free
#10
Vinita Goyal, Caitlin Canfield, Abigail R A Aiken, Amna Dermish, Joseph E Potter
OBJECTIVE: To compare preference for long-acting contraception (LARC) and subsequent use, year-long continuation, and pregnancy among women after induced abortion who were and were not eligible to participate in a specialized funding program that provided LARC at no cost. METHODS: Between October 2014 and March 2016, we conducted a prospective study of abortion patients at Planned Parenthood in Austin, Texas (located in Travis County). We compared our primary outcome of interest, postabortion LARC use, among women who were eligible for the specialized funding program (low-income, uninsured, Travis County residents) and two groups who were ineligible (low-income, uninsured, non-Travis County residents, and higher income or insured women)...
March 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28267255/a-systematic-review-examining-quality-of-life-following-pelvic-exenteration-for-locally-advanced-and-recurrent-rectal-cancer
#11
REVIEW
E Rausa, M E Kelly, L Bonavina, P R O'Connell, D C Winter
AIM: Pelvic exenteration is a complex surgical procedure associated with considerable morbidity. Quality of life (QoL) is a crucial metric of surgical outcome. The aim of this review was to assess the quality of life following pelvic exenteration for locally advanced rectal cancer (LARC) and local recurrent rectal cancer (LRRC). METHOD: A comprehensive search of studies published between 2000 and 2016 that examined quality of life outcome following pelvic exenteration was performed...
March 7, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28231251/empirical-lessons-regarding-contraception-in-a-protracted-refugee-setting-a-descriptive-study-from-maela-camp-on-the-thai-myanmar-border-1996-2015
#12
Somjet Srikanok, Daniel M Parker, Amber L Parker, Tracey Lee, Aung Myat Min, Pranee Ontuwong, Saw Oo Tan, Supachai Sirinonthachai, Rose McGready
Conflict settings and refugee camps can be chaotic places, with large and rapid population movements, exacerbated public health problems, and ad hoc health services. Reproductive health care that includes family planning is of heightened importance in such settings, however, funding and resources tend to be constrained and geared towards acute health services such as trauma management and infectious disease containment. Here we report on the complexities and challenges of providing family planning in a post-emergency refugee setting, using the example of the largest refugee camp on the Thai-Myanmar border, in existence now for over 30 years...
2017: PloS One
https://www.readbyqxmd.com/read/28216129/social-media-use-and-its-association-with-sexual-risk-and-parental-monitoring-among-a-primarily-hispanic-adolescent-population
#13
Dina L Romo, Chelsea Garnett, Alayna P Younger, Melissa S Stockwell, Karen Soren, Marina Catallozzi, Natalie Neu
STUDY OBJECTIVE: This study assesses the association between social media (SM) use with sexual risk, and with parental monitoring among Hispanic adolescents. DESIGN: Self-administered anonymous survey SETTING: Urban primary care clinics PARTICIPANTS: 13-21 year olds primarily Hispanic adolescents MAIN OUTCOME MEASURES: Chi-square and regression analyses controlling for age and gender assessed associations between SM use or sexting and sexual behaviors (kissing, touching genitals, vaginal oral, and anal sex), sexual risk (>4 lifetime partners, >1 recent partner, inconsistent condom use and history of STI diagnosis) and contraceptive use...
February 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28215379/promoting-teen-contraceptive-use-by-intervention-with-their-mothers
#14
Richard A Crosby, Tom Collins, Lindsay R Stradtman
INTRODUCTION: The purpose of this pilot study was to test a community outreach model designed to help mothers in a rural, medically underserved area navigate their teen daughters to health department services for long-acting reversible contraception (LARC) or alternative contraception. METHODS: The pilot study used a single-group, post-test only design. Mothers of teen daughters (N=142) received a 1-hour, one-to-one intervention session (in outreach settings) from Community Liaisons...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28194687/fecal-incontinence-and-radiation-dose-on-anal-sphincter-in-patients-with-locally-advanced-rectal-cancer-larc-treated-with-preoperative-chemoradiotherapy-a-retrospective-single-institutional-study
#15
F Arias, C Eito, G Asín, I Mora, K Cambra, F Mañeru, B Ibáñez, L Arbea, A Viudez, I Hernández, J I Arrarás, M Errasti, M Barrado, M Campo, I Visus, S Flamarique, M A Ciga
BACKGROUND: The objective of the study is to determine the correlations among the variables of dose and the sphincter function (SF) in patients with locally advanced rectal cancer treated with preoperative capecitabine/radiotherapy followed by low anterior resection (LAR) + TME. METHODS: We retrospectively reviewed 92 consecutive patients with LARC treated at our center with LAR from 2006 and more than 2 years free from disease. We re-contoured the anal sphincters (AS) of patients with the help of the radiologist...
February 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28193721/women-s-limited-choice-and-availability-of-modern-contraception-at-retail-outlets-and-public-sector-facilities-in-luanda-angola-2012-2015
#16
Benjamin Nieto-Andrade, Eva Fidel, Rebecca Simmons, Dana Sievers, Anya Fedorova, Suzanne Bell, Karen Weidert, Ndola Prata
In Angola, many women want to use family planning but lack access to affordable and preferred methods. This article assesses the link between women's choice and availability of contraceptive methods in Luanda, Angola, drawing on data from 3 surveys: a 2012 survey among women ages 15-49 and 2 retail surveys conducted in 2014 and 2015 among outlets and facilities offering contraceptive methods. Descriptive statistics for women's contraceptive knowledge, use, and preferred methods were stratified by age group...
February 13, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28159930/compared-planning-dosimetry-of-tomo-vmat-and-imrt-in-rectal-cancer-with-different-simulated-positions
#17
Jang-Chun Lin, Jo-Ting Tsai, Li-Jhen Chen, Ming-Hsien Li, Wei-Hsiu Liu
OBJECTIVES: To compare treatment plans for helical tomotherapy (TOMO), volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for locally advanced rectal cancer (LARC). MATERIALS AND METHODS: This retrospective study from December 2010 to June 2013 included 20 patients with LARC who received neoadjuvant concurrent chemoradiotherapy (CCRT) with radiation doses of greater than 50.4 Gy. Dosimetric quality was evaluated based on doses to organs at risk (OARs), including small bowel, urinary bladder and bilateral femoral head, over the same coverage of the clinical target volume (CTV)...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28159123/who-uses-long-acting-reversible-contraception-profile-of-larc-users-in-the-cupid-cohort
#18
Jacqueline Coombe, Melissa L Harris, Deborah Loxton
OBJECTIVE: To explore the characteristics of long-acting reversible contraception (LARC) users in a nationally representative cohort of young Australian women aged 18-23. METHODS: Data from 3155 women who responded to a question about their contraceptive use in the previous six months at the baseline Contraceptive Use, Pregnancy Intention and Decisions (CUPID) survey were included. RESULTS: 726 (19.1%) women reported LARC use, with the Implanon being the most popular method (n = 478; 65...
March 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28138443/local-advanced-rectal-cancer-perforation-in-the-midst-of-preoperative-chemoradiotherapy-a-case-report-and-literature-review
#19
Nobuhisa Takase, Kimihiro Yamashita, Yasuo Sumi, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yu-Ichiro Koma, Masato Komatsu, Ryohei Sasaki, Yoshihiro Kakeji
Standard chemoradiotherapy (CRT) for local advanced rectal cancer (LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever...
January 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28123724/clinical-implications-of-preoperative-chemoradiotherapy-prior-to-laparoscopic-surgery-for-locally-advanced-low-rectal-cancer
#20
Keisaku Kondo, Taiju Shimbo, Keitaro Tanaka, Masashi Yamamoto, Yoshifumi Narumi, Junji Okuda, Kazuhisa Uchiyama
The present study aimed to evaluate whether preoperative chemoradiotherapy (CRT) has any adverse effects on laparoscopic surgery (LS) for locally advanced low rectal cancer (LARC). The study was performed at the Osaka Medical College Hospital, and included patients who were operated on between July 2006 and December 2013. The short-term outcomes in 156 patients who underwent surgery for LARC following CRT were evaluated, of whom 152 underwent LS. Among the patients who were followed for >40 months, 77 patients (the CRT group) were compared with 39 patients who underwent LS without CRT (the surgery-alone group) for long-term outcomes...
January 2017: Molecular and Clinical Oncology
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