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https://www.readbyqxmd.com/read/28628582/revolving-loan-fund-a-novel-approach-to-increasing-access-to-long-acting-reversible-contraception-methods-in-community-health-centers
#1
Megan L Evans, Janis L Breeze, Jessica K Paulus, Audra Meadows
OBJECTIVE: The aim of this study was to assess the impact of a revolving loan fund (RLF) on timing of device insertion and long-acting reversible contraception (LARC) access among a high-risk urban population at 3 Boston community health centers. DESIGN: Three health centers were identified to implement a RLF. Each clinic received $5000 from the RLF to purchase LARC devices. Data collected through medical record review retrospectively 1 year prior to start of the RLF and prospectively for 1 year thereafter included patient demographics, type of LARC selected, patient's date of documented interest in a LARC device, and date of insertion...
June 16, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28627602/molecular-profiling-of-locally-advanced-rectal-adenocarcinoma-using-microrna-expression-review
#2
Cory Pettit, Steve Walston, Patrick Wald, Amy Webb, Terence M Williams
Treatment for locally-advanced rectal cancer (LARC) typically consists of neoadjuvant chemoradiation followed by total mesorectal excision. Recently, there has been growing interest in non-operative management for patients who are medically-inoperable or wish to avoid surgical morbidity and permanent colostomy. Approximately 50% of patients who receive pre-operative neoadjuvant chemoradiation develop some degree of pathologic response. Approximately 10-20% of patients are found to have a complete pathologic response, a finding which has frequently been shown to predict better clinical outcomes, including local-regional control, distant metastasis and survival...
June 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28609592/perimenopausal-contraception-a-practice-based-approach
#3
Deborah Bateson, Kathleen McNamee
BACKGROUND: Women who are perimenopausal are at risk of unintended pregnancy despite relatively low fertility at this stage. Contraceptive choice can be limited by increased comorbidities, but the UK Medical Eligibility Criteria (UKMEC) system provides a framework for safe prescribing. OBJECTIVE: This article provides evidence-based guidance on contraceptive options, and information to support decision-making about stopping contraception at menopause. DISCUSSION: Contraceptive choice is determined by several factors, including medical eligibility, side effects and risks, non-contraceptive benefits, cost and personal preference...
June 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28608792/sexually-transmitted-infection-prevention-with-long-acting-reversible-contraception-factors-associated-with-dual-use
#4
Erika L Thompson, Cheryl A Vamos, Stacey B Griner, Rachel Logan, Coralia Vázquez-Otero, Ellen M Daley
BACKGROUND: Long-acting reversible contraception (LARC) is extremely effective in preventing pregnancy; however, it does not provide sexually transmitted infection (STI) prevention. Therefore, dual use is recommended for the prevention of STIs, in addition to pregnancy, by using LARC methods with condoms. This study assessed factors associated with LARC only use and dual-LARC and condom use among college women. METHODS: The National College Health Assessment-II Fall 2012 to 2013 was used for this analysis...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28603932/prognostic-significance-of-tumour-regression-grade-after-neoadjuvant-chemoradiotherapy-for-a-cohort-of-locally-advanced-rectal-cancer-patients-an-8-year-retrospective-single-institutional-study
#5
Lai Xu, Songhua Cai, Tixian Xiao, Yanyu Chen, Huizhong Qiu, Bin Wu, Guole Lin, Xiyu Sun, Junyang Lu, Weixun Zhou, Yi Xiao
AIM: Locally advanced rectal cancer (LARC) is frequently treated with neoadjuvant chemoradiotherapy (NACRT) to reduce the risk of local recurrence and improve survival. Tumour response to NACRT is variable and may influence the prognosis after subsequent surgery. This study compared the prognostic values of tumour regression grade (TRG) and neoadjuvant pathologic (ypTNM) downstaging in stage II and III rectal cancer patients treated with NACRT followed by curative surgery. METHOD: This study included 185 LARC patients treated with long-course radiotherapy (45 Gy in 25 fractions) plus 5-fluorouracil over 5 weeks between 2005 and 2013...
June 11, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28599740/what-nurses-need-to-know-about-immediate-postpartum-initiation-of-long-acting-reversible-contraception
#6
Debora M Dole, Jacquelyn Martin
Initiation of long-acting reversible contraception (LARC) in the immediate postpartum period is becoming more common, resulting in increased requests for early removal, primarily because of unpredictable bleeding patterns. Competing interests of healthful spacing of pregnancies, impact on breastfeeding, risks associated with pregnancy versus contraceptive method, potential adverse effects of LARC, and timing of informed consent make immediate postpartum initiation of LARC an important issue. Nearly 40% of women do not attend a postpartum visit at all, resulting in decreased initiation of contraception and increased risk of unplanned pregnancy...
June 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/28598796/exploring-maternal-attitudes-towards-adolescent-contraception-implications-for-use-of-larc
#7
Danielle K O'Rourke-Suchoff, Kavita S Arora, Vanessa M Hildebrand, Mendel E Singer
Introduction Maternal attitudes have been shown to impact adolescent girls' sexual decision making and attitudes towards contraception. Given the potential for maternal influence on adolescent contraceptive use, we undertook an exploratory study of mothers' perceptions of the maternal role in adolescent contraceptive decision making, and maternal perceptions of long acting reversible contraceptives (LARC) for adolescent girls. Materials and methods We utilized a mixed methods study design. Acceptability of contraceptive methods and attitudes towards adolescent contraceptive use were assessed using a paper survey of 162 mothers of girls aged 11-19 years in Cleveland, Ohio, USA...
June 9, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28596122/trends-and-regional-variations-in-provision-of-contraception-methods-in-a-commercially-insured-population-in-the-united-states-based-on-nationally-proposed-measures
#8
A Law, J S Yu, W Wang, J Lin, R Lynen
OBJECTIVES: Three measures to assess the provision of effective contraception methods among reproductive-aged women have recently been endorsed for national public reporting. Based on these measures, this study examined real-world trends and regional variations of contraceptive provision in a commercially insured population in the United States. STUDY DESIGN: Women 15-44years old with continuous enrollment in each year from 2005 to 2014 were identified from a commercial claims database...
June 5, 2017: Contraception
https://www.readbyqxmd.com/read/28595169/the-addition-of-target-therapy-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer-a-review
#9
Ilaria Benevento, Francesca De Felice, Daniela Musio, Vincenzo Tombolini
Currently, neoadjuvant fluoropyrimidine-based chemoradiotherapy (CRT) is standard practice in the management of locally advanced rectal cancer (LARC). In the last decade there has been a lively interest in the improvement of clinical outcomes by modifying this standard regimen by the addition of further agents. We review combinations of targeted therapies and conventional CRT currently under investigation in LARC patients.
June 9, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28583790/transanal-endoscopic-microsurgery-after-neoadjuvant-radiochemotherapy-for-locally-advanced-extraperitoneal-rectal-cancer
#10
G Rizzo, G Zaccone, M Magnocavallo, C Mattana, D P Pafundi, M A Gambacorta, V Valentini, C Coco
PURPOSE: The aim of this study is to provide a prospective analysis of post-operative and oncological outcomes in patients affected by locally advanced rectal cancer (LARC), who obtained a major/complete clinical response after pre-operative radio-chemotherapy (RCT) and were treated with local excision (LE) by trans-anal endoscopic microsurgery (TEM) to confirm a pathological complete response (pCR) after to neo-adjuvant RCT. METHODS: All patients with LARC treated by pre-operative RCT and full-thickness LE by TEM (2000-2014) were included in the study...
May 25, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28578146/use-of-clinical-performance-measures-for-contraceptive-care-in-iowa-2013
#11
Brittni N Frederiksen, Debra J Kane, Maria Rivera, Denise Wheeler, Lorrie Gavin
OBJECTIVES: To assess feasibility of calculating clinical performance measures for contraceptive care for National Quality Forum submission: the percentage of women aged 15-44 provided: 1) a most or moderately effective contraceptive method (MME), and 2) a long-acting reversible contraceptive (LARC) method. METHODS: We used 2013 Iowa Department of Public Health (IDPH) Title X and Iowa Medicaid data. We stratified Title X data by age and Medicaid data by age and benefit type (family planning waiver (FPW) vs...
May 31, 2017: Contraception
https://www.readbyqxmd.com/read/28577059/totally-laparoscopic-right-colectomy-versus-laparoscopically-assisted-right-colectomy-a-propensity-score-analysis
#12
Alberto Biondi, Pietro Santocchi, Francesco Pennestrì, Francesco Santullo, Domenico D'Ugo, Roberto Persiani
INTRODUCTION: The aim of this study is to compare short- and long-term outcomes of totally laparoscopic right colectomy (TLRC) and laparoscopically assisted right colectomy (LARC), using propensity score matching (PSM) analysis. MATERIALS AND METHODS: A retrospective analysis of patients who underwent laparoscopic right colectomy between January 2006 and July 2016 was conducted. PSM analysis was performed to overcome patient selection bias between the two surgical techniques...
June 2, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28558091/long-acting-reversible-contraception-for-adolescents-a-review
#13
Jenny K R Francis, Melanie A Gold
Importance: Adolescents have higher rates of unintended pregnancies than any other age group. Contraceptive implants and intrauterine devices (IUDs) are long-acting reversible contraceptives (LARCs) that are known to be highly effective in preventing pregnancy. New devices have recently been approved for use in adolescents, yet pediatricians may be less familiar with how to counsel adolescents about implants and IUDs. Observations: LARC methods should be described in basic terms to adolescents, including hormone dose, method of insertion, and method of pregnancy prevention...
May 30, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28537875/n-myc-downstream-regulated-gene-1-promotes-oxaliplatin-triggered-apoptosis-in-colorectal-cancer-cells-via-enhancing-the-ubiquitination-of-bcl-2
#14
Xiao Yang, Fan Zhu, Chaoran Yu, Jiaoyang Lu, Luyang Zhang, Yanfeng Lv, Jing Sun, Minhua Zheng
N-myc downstream-regulated gene1 (NDRG1) has been identified as a potent tumor suppressor gene. The molecular mechanisms of anti-tumor activity of NDRG1 involve its suppressive effects on a variety of tumorigenic signaling pathways. The purpose of this study was to investigate the role of NDRG1 in the apoptosis of colorectal cancer (CRC) cells. We first collected the clinical data of locally advanced rectal cancer (LARC) patients receiving oxaliplatin-based neoadjuvant chemotherapy in our medical center. Correlation analysis revealed that NDRG1 positively associated with the downstaging rates and prognosis of patients...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514763/the-value-of-diffusion-kurtosis-imaging-in-assessing-pathological-complete-response-to-neoadjuvant-chemoradiation-therapy-in-rectal-cancer-a-comparison-with-conventional-diffusion-weighted-imaging
#15
Feixiang Hu, Wei Tang, Yiqun Sun, Dang Wan, Sanjun Cai, Zhen Zhang, Robert Grimm, Xu Yan, Caixia Fu, Tong Tong, Weijun Peng
OBJECTIVES: The aim of this study is to comprehensively evaluate the advantage of diffusion kurtosis imaging (DKI) in distinguishing pathological complete response (pCR) from non-pCR patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation therapy (CRT) in comparison to conventional diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Fifty-six consecutive patients diagnosed with LARC were prospectively enrolled and underwent pre- and post-CRT MRI on a 3...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28502827/provider-and-health-system-factors-associated-with-usage-of-long-acting-reversible-contraception-in-adolescents
#16
Anna Jo Bodurtha Smith, Kathleen F Harney, Tara Singh, Anita Gupta Hurwitz
STUDY OBJECTIVE: Long-acting reversible contraception (LARC) is recommended as first-line contraception for adolescents. Surveys of primary care providers suggest that physician and clinic factors may influence LARC counseling, but their impact on usage is unknown. Our objective was to explore provider and clinic characteristics associated with LARC usage in adolescents. STUDY DESIGN: We conducted a cross-sectional study of 5363 women ages 15-21 years receiving primary care within a large health system in Massachusetts in 2015...
May 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28502421/is-neoadjuvant-chemoradiotherapy-always-necessary-for-mid-high-local-advanced-rectal-cancer-a-comparative-analysis-after-propensity-score-matching
#17
Y Zhang, Y Sun, Z Xu, P Chi, X Lu
AIM: This study was aimed to compare perioperative and oncological outcomes of mid/high locally advanced midrectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (NCRT) vs. surgery alone, and to identify risk factors for local recurrence in mid/high LARC. METHOD: A total of 471 mid/high LARC patients treated with surgery alone or NCRT (50.4 Gy in 28 fractions) with concurrent FOLFOX/XELOX followed by TME in 6-8 weeks from 2008 to 2014 were matched 1:1 by using propensity score analysis...
May 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28499428/clinical-benefit-of-adding-oxaliplatin-to-standard-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer-a-meta-analysis-oxaliplatin-in-neoadjuvant-treatment-for-rectal-cancer
#18
Francesca De Felice, Ilaria Benevento, Anna Lisa Magnante, Daniela Musio, Nadia Bulzonetti, Rossella Caiazzo, Vincenzo Tombolini
BACKGROUND: Neoadjuvant fluoropirimidine (5FU)-based chemoradiotherapy (CRT) has been considered the standard of care for locally advanced rectal cancer (LARC). Whether addition of oxaliplatin (OXP) will further improve clinical outcomes is still debated. We conducted a meta-analysis to evaluate the role of OXP in this patient population. METHODS: Literature searches were carried out in PubMed, Medline and Scopus databases. End points were overall survival (OS), disease free survival (DFS), local failure (LF) and distant failure (DF)...
May 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28497403/locally-advanced-rectal-cancer-predicting-non-responders-to-neoadjuvant-chemoradiotherapy-using-apparent-diffusion-coefficient-textures
#19
Ming Liu, Han Lv, Li-Heng Liu, Zheng-Han Yang, Er-Hu Jin, Zhen-Chang Wang
PURPOSE: The purpose of the study is to evaluate whether apparent diffusion coefficient (ADC) textures could identify patient with locally advanced rectal cancer (LARC) who would not respond to neoadjuvant chemoradiotherapy (NCRT). METHOD: Twenty-six patients who underwent MRI including diffusion-weighted imaging at a 3.0 T system before NCRT were enrolled. Texture analysis of pre-therapy ADC mapping was carried out, and a total of 133 ADC textures as well as routine mean ADC value of the primary tumor were extracted for each patient...
May 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28492087/sociodemographic-characteristics-associated-with-the-use-of-effective-and-less-effective-contraceptive-methods-findings-from-the-understanding-fertility-management-in-contemporary-australia-survey
#20
Karen Freilich, Sara Holton, Heather Rowe, Maggie Kirkman, Lynne Jordan, Kathleen McNamee, Christine Bayly, John McBain, Vikki Sinnott, Jane Fisher
OBJECTIVE: Unintended pregnancy and abortion may, in part, result from suboptimal use of effective contraception. This study aimed to identify sociodemographic factors associated with the use of effective and less effective methods among women and men of reproductive age living in Australia. METHODS: In a cross-sectional national survey, 1544 women and men aged 18-51 were identified as being at risk of pregnancy. Chi-square and logistic regression analyses were used to assess the sociodemographic factors related to contraceptive use...
May 11, 2017: European Journal of Contraception & Reproductive Health Care
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