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Mario plebani

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https://www.readbyqxmd.com/read/28210831/cardiac-biomarkers-of-acute-coronary-syndrome-from-history-to-high-sensitive-cardiac-troponin
#1
Mario Plebani, Giorgia Antonelli, Martina Zaninotto
No abstract text is available yet for this article.
February 17, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28207411/reporting-altered-test-results-in-hemolyzed-samples-is-the-cure-worse-than-the-disease
#2
Giuseppe Lippi, Gianfranco Cervellin, Mario Plebani
The management of laboratory data in unsuitable (hemolyzed) samples remains an almost unresolved dilemma. Whether or not laboratory test results obtained by measuring unsuitable specimens should be made available to the clinicians has been the matter of fierce debates over the past decades. Recently, an intriguing alternative to suppressing test results and recollecting the specimen has been put forward, entailing the definition and implementation of specific algorithms that would finally allow reporting a preanalytically altered laboratory value within a specific comment about its uncertainty of measurement...
February 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28187222/impaired-release-of-vitamin-d-in-dysfunctional-adipose-tissue-new-cues-on-vitamin-d-supplementation-in-obesity
#3
Andrea Di Nisio, Luca De Toni, Iva Sabovic, Maria Santa Rocca, Vincenzo De Filippis, Giuseppe Opocher, Bruno Azzena, Roberto Vettor, Mario Plebani, Carlo Foresta
No abstract text is available yet for this article.
February 10, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28183314/dpp-4-inhibition-has-no-acute-effect-on-bnp-and-its-n-terminal-pro-hormone-measured-by-commercial-immune-assays-a-randomized-cross-over-trial-in-patients-with-type-2-diabetes
#4
Gian Paolo Fadini, Benedetta Maria Bonora, Mattia Albiero, Martina Zaninotto, Mario Plebani, Angelo Avogaro
BACKGROUND: Use of dipeptidyl peptidase-4 inhibitors (DPP4-i) for the treatment of type 2 diabetes (T2D) has been associated with a possible increase in the risk for heart failure (HF). B-type natriuretic peptide (BNP), which is both a biomarker of HF and a hemodynamically active hormone, is a substrate of DPP-4. We herein tested the acute effects of the DPP-4i linagliptin on BNP and NT-proBNP in a cross-over placebo-controlled trial in patients with T2D with and without chronic kidney disease (CKD)...
February 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28167641/prognostic-utility-of-a-modified-heart-score-in-chest-pain-patients-in-the-emergency-department
#5
James McCord, Rafael Cabrera, Bertil Lindahl, Evangelos Giannitsis, Kaleigh Evans, Richard Nowak, Tiberio Frisoli, Richard Body, Michael Christ, Christopher R deFilippi, Robert H Christenson, Gordon Jacobsen, Aitor Alquezar, Mauro Panteghini, Dina Melki, Mario Plebani, Franck Verschuren, John French, Garnet Bendig, Silvia Weiser, Christian Mueller
BACKGROUND: The TRAPID-AMI trial study (High-Sensitivity Troponin-T Assay for Rapid Rule-Out of Acute Myocardial Infarction) evaluated high-sensitivity cardiac troponin-T (hs-cTnT) in a 1-hour acute myocardial infarction (AMI) exclusion algorithm. Our study objective was to evaluate the prognostic utility of a modified HEART score (m-HS) within this trial. METHODS AND RESULTS: Twelve centers evaluated 1282 patients in the emergency department for possible AMI from 2011 to 2013...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28167246/performance-specifications-for-the-extra-analytical-phases-of-laboratory-testing-why-and-how
#6
REVIEW
Mario Plebani
An important priority in the current healthcare scenario should be to address errors in laboratory testing, which account for a significant proportion of diagnostic errors. Efforts made in laboratory medicine to enhance the diagnostic process have been directed toward improving technology, greater volumes and more accurate laboratory tests being achieved, but data collected in the last few years highlight the need to re-evaluate the total testing process (TTP) as the unique framework for improving quality and patient safety...
February 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28153366/quality-indicators-for-the-total-testing-process
#7
REVIEW
Mario Plebani, Laura Sciacovelli, Ada Aita
ISO 15189:2012 requires the use of quality indicators (QIs) to monitor and evaluate all steps of the total testing process, but several difficulties dissuade laboratories from effective and continuous use of QIs in routine practice. An International Federation of Clinical Chemistry and Laboratory Medicine working group addressed this problem and implemented a project to develop a model of QIs to be used in clinical laboratories worldwide to monitor and evaluate all steps of the total testing process, and decrease error rates and improve patient services in laboratory testing...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28125403/innovative-software-for-recording-preanalytical-errors-in-accord-with-the-ifcc-quality-indicators
#8
Giuseppe Lippi, Laura Sciacovelli, Ana-Maria Simundic, Mario Plebani
No abstract text is available yet for this article.
March 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28117338/beta-agonist-stimulation-ameliorates-the-phenotype-of-spinal-and-bulbar-muscular-atrophy-mice-and-patient-derived-myotubes
#9
Carmelo Milioto, Adriana Malena, Eleonora Maino, Maria J Polanco, Caterina Marchioretti, Doriana Borgia, Marcelo Gomes Pereira, Bert Blaauw, Andrew P Lieberman, Roberta Venturini, Mario Plebani, Fabio Sambataro, Lodovica Vergani, Elena Pegoraro, Gianni Sorarù, Maria Pennuto
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR). Expression of polyglutamine-expanded AR causes damage to motor neurons and skeletal muscle cells. Here we investigated the effect of β-agonist stimulation in SBMA myotube cells derived from mice and patients, and in knock-in mice. We show that treatment of myotubes expressing polyglutamine-expanded AR with the β-agonist clenbuterol increases their size...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28099122/parathormone-stability-in-hemodialyzed-patients-and-healthy-subjects-comparison-on-non-centrifuged-edta-and-serum-samples-with-second-and-third-generation-assays
#10
Marie-Louise Schleck, Jean-Claude Souberbielle, Pierre Delanaye, Mario Plebani, Etienne Cavalier
BACKGROUND: Parathyroid hormone (PTH) stability is important. Many studies have shown divergent results between EDTA and serum, which are mainly linked to differences in protocols or cut-offs used to determine whether or not PTH remained stable. No studies have yet compared PTH stability as measured by second- and third-generation assays on the same samples in hemodialyzed patients and healthy subjects. METHODS: Five pairs of samples (EDTA and gel tubes) were obtained in 10 hemodialyzed patients before a dialysis session and in 10 healthy subjects...
January 18, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28017363/statins-for-primary-prevention-of-cardiovascular-disease
#11
Giuseppe Lippi, Mario Plebani
The US Preventive Services Task Force has recently recommended the use of statins in primary prevention of cardiovascular disease in adults. Doubts remain as to whether this approach is really cost-effective, and additional drawbacks include the increasing burden of potential side effects and incremental costs due to laboratory monitoring.
December 22, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27988505/quality-indicators-in-laboratory-medicine-the-status-of-the-progress-of-ifcc-working-group-laboratory-errors-and-patient-safety-project
#12
Laura Sciacovelli, Giuseppe Lippi, Zorica Sumarac, Jamie West, Isabel Garcia Del Pino Castro, Keila Furtado Vieira, Agnes Ivanov, Mario Plebani
The knowledge of error rates is essential in all clinical laboratories as it enables them to accurately identify their risk level, and compare it with those of other laboratories in order to evaluate their performance in relation to the State-of-the-Art (i.e. benchmarking) and define priorities for improvement actions. Although no activity is risk free, it is widely accepted that the risk of error is minimized by the use of Quality Indicators (QIs) managed as a part of laboratory improvement strategy and proven to be suitable monitoring and improvement tools...
March 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27942515/streamlining-laboratory-expenditures-through-direct-to-consumer-testing-and-reference-prices-first-do-not-harm
#13
EDITORIAL
Giuseppe Lippi, Mario Plebani
No abstract text is available yet for this article.
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27932414/serial-sampling-of-high-sensitivity-cardiac-troponin-t-may-not-be-required-for-prediction-of-acute-myocardial-infarction-diagnosis-in-chest-pain-patients-with-highly-abnormal-concentrations-at-presentation
#14
Matthias Mueller-Hennessen, Christian Mueller, Evangelos Giannitsis, Moritz Biener, Mehrshad Vafaie, Christopher R deFilippi, Michael Christ, Jorge Ordóñez-Llanos, Mauro Panteghini, Mario Plebani, Franck Verschuren, Dina Melki, John K French, Robert H Christenson, Richard Body, James McCord, Carina Dinkel, Hugo A Katus, Bertil Lindahl
BACKGROUND: Guidelines for diagnosing acute myocardial infarction (AMI) recommend adding kinetic changes to the initial cardiac troponin (cTn) blood concentration to improve AMI diagnosis. We hypothesized that kinetic changes may not be required in patients presenting with highly abnormal cTn. METHODS: Patients presenting with suspected AMI to the emergency department were enrolled in a prospective diagnostic study. We assessed the positive predictive value (PPV) of initial high-sensitivity cardiac troponin T (hs-cTnT) blood concentrations alone and in combination with kinetic changes for AMI...
December 8, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27847340/relevance-of-pre-analytical-blood-management-on-the-emerging-cardiovascular-protein-biomarkers-tweak-and-hmgb1-and-on-mirna-serum-and-plasma-profiling
#15
Daniela Basso, Andrea Padoan, Thomas Laufer, Vittorio Aneloni, Stefania Moz, Hannah Schroers, Michela Pelloso, Anna Saiz, Medea Krapp, Paola Fogar, Paola Cornoldi, Carlo-Federico Zambon, Elisa Rossi, Marco La Malfa, Alberto Marotti, Thomas Brefort, Tanja M Weis, Hugo A Katus, Mario Plebani
BACKGROUND: Disease-independent sources of biomarker variability include pre-analytical, analytical and biological variance. The aim of the present study was to evaluate whether the pre-analytical phase has any impact on the emerging heart disease TWEAK and HMGB1 protein markers and miRNA biomarkers, and whether peptidome profiling allows the identification of pre-analytical quality markers. METHODS: An assessment was made of sample type (serum, EDTA-Plasma, Citrate-Plasma, ACD-plasma, Heparin-plasma), temperature of sample storage (room temperature or refrigerated), time of sample storage (0...
November 12, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27816950/performance-evaluation-of-immunocap%C3%A2-isac-112-a-multi-site-study
#16
Marianne van Hage, Peter Schmid-Grendelmeier, Chrysanthi Skevaki, Mario Plebani, Walter Canonica, Jörg Kleine-Tebbe, Mats Nystrand, Mehrdad Jafari-Mamaghani, Thilo Jakob
BACKGROUND: After the re-introduction of ImmunoCAP® ISAC sIgE 112 on the market, we undertook a study to evaluate the performance of this multiplex-based immunoassay for IgE measurements to allergen components. METHODS: The study was carried out at 22 European and one South African site. Microarrays from different batches, eight specific IgE (sIgE) positive, three sIgE negative serum samples and a calibration sample were sent to participating laboratories where assays were performed according to the manufacturer's instructions...
November 7, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27760306/quality-in-laboratory-medicine-50years-on
#17
Mario Plebani
The last 50years have seen substantial changes in the landscape of laboratory medicine: its role in modern medicine is in evolution and the quality of laboratory services is changing. The need to control and improve quality in clinical laboratories has grown hand in hand with the growth in technological developments leading to an impressive reduction of analytical errors over time. An essential cause of this impressive improvement has been the introduction and monitoring of quality indicators (QIs) such as the analytical performance specifications (in particular bias and imprecision) based on well-established goals...
October 17, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27754963/opportunities-and-drawbacks-of-nonstandard-body-fluid-analysis
#18
Giuseppe Lippi, Mario Plebani
No abstract text is available yet for this article.
October 18, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27732557/towards-a-new-paradigm-in-laboratory-medicine-the-five-rights
#19
Mario Plebani
A body of evidence collected in the last few decades demonstrates that the pre- and post-analytical phases of the testing cycle are more error-prone than the analytical phase. However, the paradigm of errors and quality in laboratory medicine has been questioned, analytical mistakes continuing to be a major cause of adverse clinical outcomes and patient harm. Although the brain-to-brain concept is widely recognized in the community of laboratory professionals, there is lack of clarity concerning the inter-relationship between the different phases of the cycle, interdependence between the pre-analytical phase and analytical quality, and the effect of the post-analytical steps on the quality of ultimate laboratory information...
December 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27732556/vitamin-k-plasma-levels-determination-in-human-health
#20
Maria Fusaro, Maurizio Gallieni, Maria Antonietta Rizzo, Andrea Stucchi, Pierre Delanaye, Etienne Cavalier, Rosa M A Moysés, Vanda Jorgetti, Giorgio Iervasi, Sandro Giannini, Fabrizio Fabris, Andrea Aghi, Stefania Sella, Francesco Galli, Valentina Viola, Mario Plebani
Vitamin K (phylloquinone or vitamin K1 and menaquinones or vitamin K2) plays an important role as a cofactor in the synthesis of hepatic blood coagulation proteins, but recently has also aroused an increasing interest for its action in extra-hepatic tissues, in particular in the regulation of bone and vascular metabolism. The accurate measurement of vitamin K status in humans is still a critical issue. Along with indirect assays, such as the undercarboxylated fractions of vitamin K-dependent proteins [prothrombin, osteocalcin (OC), and matrix gla protein], the direct analysis of blood levels of phylloquinone and menaquinones forms might be considered a more informative and direct method for assessing vitamin K status...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
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