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Mario plebani

Mario Plebani
A body of evidence collected in the last few decades demonstrates that the pre- and post-analytical phases of the testing cycle are more error-prone than the analytical phase. However, the paradigm of errors and quality in laboratory medicine has been questioned, analytical mistakes continuing to be a major cause of adverse clinical outcomes and patient harm. Although the brain-to-brain concept is widely recognized in the community of laboratory professionals, there is lack of clarity concerning the inter-relationship between the different phases of the cycle, interdependence between the pre-analytical phase and analytical quality, and the effect of the post-analytical steps on the quality of ultimate laboratory information...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Maria Fusaro, Maurizio Gallieni, Maria Antonietta Rizzo, Andrea Stucchi, Pierre Delanaye, Etienne Cavalier, Rosa M A Moysés, Vanda Jorgetti, Giorgio Iervasi, Sandro Giannini, Fabrizio Fabris, Andrea Aghi, Stefania Sella, Francesco Galli, Valentina Viola, Mario Plebani
Vitamin K (phylloquinone or vitamin K1 and menaquinones or vitamin K2) plays an important role as a cofactor in the synthesis of hepatic blood coagulation proteins, but recently has also aroused an increasing interest for its action in extra-hepatic tissues, in particular in the regulation of bone and vascular metabolism. The accurate measurement of vitamin K status in humans is still a critical issue. Along with indirect assays, such as the undercarboxylated fractions of vitamin K-dependent proteins [prothrombin, osteocalcin (OC), and matrix gla protein], the direct analysis of blood levels of phylloquinone and menaquinones forms might be considered a more informative and direct method for assessing vitamin K status...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Linoj Samuel, Mario Plebani
No abstract text is available yet for this article.
October 8, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Mario Plebani
No abstract text is available yet for this article.
October 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Andrea Di Nisio, Maria Santa Rocca, Gian Paolo Fadini, Luca DeToni, Giorgio Marcuzzo, Maria Cristina Marescotti, Marta Sanna, Mario Plebani, Roberto Vettor, Angelo Avogaro, Carlo Foresta
OBJECTIVE: Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism rs2274911 in GPRC6A was shown to be associated with testicular impairment. We aimed to investigate the role of rs2274911 polymorphism in glucose and lipid metabolism in a cohort of normal weight and obese subjects DESIGN, PATIENTS, SETTINGS: A total of 392 male and females, including 218 obese patients and 174 age-matched normal weight controls were retrospectively selected...
October 1, 2016: Clinical Endocrinology
Mario Plebani
According to a patient-centered viewpoint, the meaning of harmonization in the context of laboratory medicine is that the information should be comparable irrespective of the measurement procedure used and where and/or when a measurement is made. Harmonization represents a fundamental aspect of quality in laboratory medicine as its ultimate goal is to improve patient outcomes through the provision of an accurate and actionable laboratory information. Although the initial focus has to a large extent been to harmonize and standardize analytical processes and methods, the scope of harmonization goes beyond to include all other aspects of the total testing process (TTP), such as terminology and units, report formats, reference intervals and decision limits, as well as tests and test profiles request and criteria for interpretation...
February 2016: EJIFCC
Mario Plebani, Maurice O'Kane, Pieter Vermeersch, Janne Cadamuro, Wytze Oosterhuis, Laura Sciacovelli
No abstract text is available yet for this article.
November 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Luca De Toni, Diego Guidolin, Vincenzo De Filippis, Simone Tescari, Giacomo Strapazzon, Maria Santa Rocca, Alberto Ferlin, Mario Plebani, Carlo Foresta
The undercarboxylated form of osteocalcin (ucOC) regulates male fertility and energy metabolism, acting through the G protein-coupled receptor GPRC6A thus forming a new pancreas-bone-testis axis. Recently, GPRC6A has also been suggested to mediate the non-genomic responses of free testosterone (T). However, these data did not consider the physiological scenario, where circulating T is mainly bound to sex hormone-binding globulin (SHBG) and only a small percentage circulates freely in the blood. Here, by the use of computational modelling, we document the existence of similar structural moieties between ucOC and SHBG that are predicted to bind to GPRC6A at docking analysis...
September 27, 2016: Endocrinology
Samuel Vasikaran, Kenneth Sikaris, Eric Kilpatrick, Jane French, Tony Badrick, Jacqui Osypiw, Mario Plebani
The provision of interpretative advice on laboratory results is a post-analytic activity and an integral part of clinical laboratory services. It is valued by healthcare workers and has the potential to prevent or reduce errors and improve patient outcomes. It is important to ensure that interpretative comments provided by laboratory personnel are of high quality: comments should be patient-focused and answer the implicit or explicit question raised by the requesting clinician. Comment providers need to be adequately trained and qualified and be able to demonstrate their proficiency to provide advice on laboratory reports...
September 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Daniela Di Martino, Irene Cetin, Tiziana Frusca, Enrico Ferrazzi, Federica Fuse', Maria Teresa Gervasi, Mario Plebani, Tullia Todros
Extensive research has been published, showing the usefulness of angiogenic markers in both diagnosis and subsequent prediction and management of preeclampsia and placenta-related disorders. Recent evidence provides a helpful cut off for the Elecsys ratio sFlt-1 to PlGF, that predicts preeclampsia development in women with sign and symptoms, before its clinical onset in the short term. In Europe, no accordance exists for the use of such kind of test in clinical practice; only German guidelines have recently taken it into account, as a diagnostic aid for preeclampsia, in conjunction with other clinical findings...
September 1, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Eleftherios P Diamandis, Mario Plebani
No abstract text is available yet for this article.
October 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Elvira Eva Moreno-Campoy, Francisco J Mérida-De la Torre, Francisco Martos-Crespo, Mario Plebani
No abstract text is available yet for this article.
August 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Giulia Polo, Alessandro P Burlina, Thilini B Kolamunnage, Michele Zampieri, Carlo Dionisi-Vici, Pietro Strisciuglio, Martina Zaninotto, Mario Plebani, Alberto B Burlina
BACKGROUND: Lysosphingolipids (LysoSLs) are derivatives of sphingolipids which have lost the amide-linked acyl chain. More recently, LysoSLs have been identified as storage compounds in several sphingolipidoses, including Gaucher, Fabry and Niemann-Pick diseases. To date, different methods have been developed to measure each individual lysosphingolipid in plasma. This report describes a rapid liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) assay for simultaneous quantification of several LysoSLs in plasma...
August 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Nuthar Jassam, Cas WeyKamp, Annette Thomas, Sandra Secchiero, Mario Plebani, Laura Sciacovelli, Marc Thelen, Christa Cobbaert, Carmen Perich, Carmen Ricos, Ana-Paula Faria, Julian H Barth
INTRODUCTION: Reliable serum creatinine measurements are of vital importance for the correct classification of chronic kidney disease (CKD) and early identification of kidney injury. The National Kidney Disease Education Programme (NKDEP) working group and other groups have defined clinically acceptable analytical limits for creatinine methods. The aim of this study was to re-evaluate the performance of routine creatinine methods in the light of these defined limits so as to assess their suitability for clinical practice...
August 5, 2016: Annals of Clinical Biochemistry
Giuseppe Lippi, Mario Plebani
No abstract text is available yet for this article.
August 1, 2016: JAMA Internal Medicine
Cas Weykamp, Sandra Secchiero, Mario Plebani, Marc Thelen, Christa Cobbaert, Annette Thomas, Nuthar Jassam, Julian H Barth, Carmen Perich, Carmen Ricós, Ana Paula Faria
BACKGROUND: Optimum patient care in relation to laboratory medicine is achieved when results of laboratory tests are equivalent, irrespective of the analytical platform used or the country where the laboratory is located. Standardization and harmonization minimize differences and the success of efforts to achieve this can be monitored with international category 1 external quality assessment (EQA) programs. METHODS: An EQA project with commutable samples, targeted with reference measurement procedures (RMPs) was organized by EQA institutes in Italy, the Netherlands, Portugal, UK, and Spain...
July 22, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Karl J Lackner, Philippe Gillery, Giuseppe Lippi, Bohuslav Melichar, Peter Schlattmann, Jill R Tate, Mario Plebani
No abstract text is available yet for this article.
September 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Felice Simiele, Antonio Recchiuti, Sara Patruno, Roberto Plebani, Anna Maria Pierdomenico, Marilina Codagnone, Mario Romano
Lipoxin (LX) A4, a main stop signal of inflammation, exerts potent bioactions by activating a specific G protein-coupled receptor, termed formyl peptide receptor 2 and recently renamed ALX/FPR2. Knowledge of the regulatory mechanisms that drive ALX/FPR2 gene expression is key for the development of innovative anti-inflammatory pharmacology. Here, we examined chromatin patterns of the ALX/FPR2 gene. We report that in MDA-MB231 breast cancer cells, the ALX/FPR2 gene undergoes epigenetic silencing characterized by low acetylation at lysine 27 and trimethylation at lysine 4, associated with high methylation at lysine 27 of histone 3...
October 2016: Biochimica et Biophysica Acta
Christian Mueller, Evangelos Giannitsis, Martin Möckel, Kurt Huber, Johannes Mair, Mario Plebani, Kristian Thygesen, Allan S Jaffe, Bertil Lindahl
No abstract text is available yet for this article.
July 1, 2016: European Heart Journal. Acute Cardiovascular Care
Giuseppe Lippi, Mario Plebani
No abstract text is available yet for this article.
October 1, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
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