Emna Abidi, Wasim S El Nekidy, Bassam Atallah, Khaled Al Zaman, Praveen Ghisulal, Rania El Lababidi, Yosef Manla, Ihab Ahmed, Ziad Sadik, Ahmed Taha, Mohamed Askalany, Antoine Cherfan, Mohamed Helal, Saad Sultan, Umar Khan, Vivek Kakar, Jihad Mallat
There has been a substantial increase in the use of extracorporeal membrane oxygenation (ECMO) support in critically ill adults. Understanding the complex changes that could affect drugs' pharmacokinetics (PK) and pharmacodynamics (PD) is of suitable need. Therefore, critically ill patients on ECMO represent a challenging clinical situation to manage pharmacotherapy. Thus, clinicians' ability to predict PK and PD alterations within this complex clinical context is fundamental to ensure further optimal and, sometimes, individualized therapeutic plans that balance clinical outcomes with the minimum drug adverse events...
May 29, 2023: Journal of Clinical Medicine