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https://www.readbyqxmd.com/read/29325023/the-extending-spectrum-of-npc1-related-human-disorders-from-niemann-pick-c1-disease-to-obesity
#1
Amel Lamri, Marie Pigeyre, William S Garver, David Meyre
The Niemann-Pick C1 (NPC1) protein regulates the transport of cholesterol and fatty acids from late endosomes / lysosomes and has a central role in maintaining lipid homeostasis. NPC1 loss-of-function mutations in humans cause NPC1 disease, a rare autosomal-recessive lipid-storage disorder characterized by progressive and lethal neurodegeneration, liver and lung failure, due to cholesterol infiltration. In humans, genome wide association studies (GWAS) and post-GWAS reports highlight the implication of common variants in NPC1 in adult-onset obesity, body fat mass, and type 2 diabetes...
January 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29324728/recommendation-of-the-advisory-committee-on-immunization-practices-for-use-of-a-third-dose-of-mumps-virus-containing-vaccine-in-persons-at-increased-risk-for-mumps-during-an-outbreak
#2
Mona Marin, Mariel Marlow, Kelly L Moore, Manisha Patel
A substantial increase in the number of mumps outbreaks and outbreak-associated cases has occurred in the United States since late 2015 (1,2). To address this public health problem, the Advisory Committee on Immunization Practices (ACIP) reviewed the available evidence and determined that a third dose of measles, mumps, rubella (MMR) vaccine is safe and effective at preventing mumps. During its October 2017 meeting, ACIP recommended a third dose of a mumps virus-containing vaccine* for persons previously vaccinated with 2 doses who are identified by public health authorities as being part of a group or population at increased risk for acquiring mumps because of an outbreak...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29324621/immediate-delivery-compared-with-expectant-management-in-late-preterm-prelabor-rupture-of-membranes-an-individual-participant-data-meta-analysis
#3
Johanna Quist-Nelson, Annemijn A de Ruigh, Anna Lene Seidler, David P van der Ham, Christine Willekes, Vincenzo Berghella, Eva Pajkrt, Jillian Patterson, David Espinoza, Jonathan Morris, Ben Mol, Lisa Askie
OBJECTIVE: To compare the effects of immediate delivery an expectant management among women whose pregnancies were complicated by preterm prelabor rupture of membranes (PROM) in the late preterm period (from 34 0/7 weeks until 36 6/7 weeks of gestation). DATA SOURCES: PubMed, Scopus, ClinicalTrials.gov, EMBASE, and the Cochrane Central Register of Controlled Trials were searched from inception until December 2016. METHODS OF STUDY SELECTION: We included all randomized controlled trials with individual participant data reporting on late preterm PROM with randomization to immediate delivery or expectant management...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29320882/the-impact-of-influenza-virus-infection-in-pregnancy
#4
Lucy K Somerville, Kerri Basile, Dominic E Dwyer, Jen Kok
Data from previous seasonal epidemics and pandemics have confirmed that pregnant women are at increased risk for severe influenza virus infection. Complications including fetal loss, higher rates of hospitalization and maternal death are most notable during the late gestational period. Antiviral therapy and influenza vaccination are recommended in pregnant women as both are effective and safe. This review discusses the epidemiology, pathophysiology, treatment and prevention of influenza virus infection in pregnancy, with a focus on recent developments...
January 11, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29318449/reduction-oxidation-redox-system-in-radiation-induced-normal-tissue-injury-molecular-mechanisms-and-implications-in-radiation-therapeutics
#5
REVIEW
R Yahyapour, E Motevaseli, A Rezaeyan, H Abdollahi, B Farhood, M Cheki, S Rezapoor, D Shabeeb, A E Musa, M Najafi, V Villa
Every year, millions of cancer patients undergo radiation therapy for treating and destroying abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation can have positive therapeutic effects on cancer cells as well as post-detrimental effects on surrounding normal tissues. Previous studies in the past years have proposed that the reduction and oxidation metabolism in cells changes in response to ionizing radiation and has a key role in radiation toxicity to normal tissue. Free radicals generated from ionizing radiation result in upregulation of cyclooxygenases (COXs), nitric oxide synthase (NOSs), lipoxygenases (LOXs) as well as nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), and their effected changes in mitochondrial functions are markedly noticeable...
January 9, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29317068/etiological-mechanism-of-iridocorneal-endothelial-ice-syndrome-may-involve-infection-of-herpes-simplex-virus-hsv-and-integration-of-viral-genes-into-human-genome
#6
Fei Li, Yaoming Liu, Yi Sun, Xiulan Zhang
Iridocorneal (ICE) syndrome is a rare ocular disease characterized by abnormal proliferation of corneal endothelial cells, progressive obstruction of irido-corneal angle and atrophy of iris. ICE syndrome progressed slowly, but can cause serious complications such as secondary glaucoma in late stage. Because the etiology of ICE syndrome is not clear, there is still no effective treatment in clinical practice. Previous studies have detected herpes simplex virus (HSV) DNA inside patient's aqueous humor. However, no further explanation for HSV-related etiology of ICE syndrome was established...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29313557/delayed-and-life-threatening-hematuria-following-percutaneous-nephrostomy-placement
#7
Daniele Castellani
INTRODUCTION: Percutaneous nephrostomy (PN) is a common urological procedure with mild complications in most cases. CASE DESCRIPTION: We present a case of massive and life-threatening hematuria, presenting 29 days following PN. This is an uncommon complication of PN due to a delayed rupture of a pseudoaneurysm (PA) arising from a segmental artery. Bleeding was successfully treated by percutaneous trans-arterial super-selective embolization. CONCLUSIONS: Hematuria, due to PA formation, should always be kept in mind in case of late hematuria following PN, as it needs to be promptly treated...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29313454/a-multicenter-experience-with-a-new-fenestrated-branched-device-for-endovascular-repair-of-thoracoabdominal-aortic-aneurysms
#8
Marwan Youssef, Sebastien Deglise, Piotr Szopinski, Schäfer Jost-Philipp, Amer Jomha, Christian F Vahl, Ahmed Koshty
PURPOSE: To investigate the outcomes of patients who were treated for thoracoabdominal aortic aneurysms (TAAAs) using custom-made fenestrated-branched stent-grafts. METHODS: A consecutive series of 108 patients (mean age 73.5 years; 73 men) with TAAA were treated with E-xtra Design Engineering customized fenestrated-branched stent-grafts between November 2011 and January 2017. Data on baseline characteristics, procedures, and clinical follow-up were collected from 6 regional European surgical centers for retrospective analysis of endoleaks, reinterventions, and target vessel patency...
January 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29313123/15-year-experience-of-laparoscopic-single-anastomosis-mini-gastric-bypass-comparison-with-other-bariatric-procedures
#9
Nawaf Alkhalifah, Wei-Jei Lee, Tan Chun Hai, Kong-Han Ser, Jung-Chien Chen, Chun-Chi Wu
BACKGROUND: Laparoscopic single anastomosis (mini-)gastric bypass (LSAGB) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remain lacking. METHODS: Between October 2001 and December 2015, 1731 morbidly obese patients who received LSAGB as primary bariatric procedure at the Min-Sheng General Hospital were recruited. Surgical outcome, weight loss, resolution of comorbidities, and late complications were followed, then compared with groups of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG)...
January 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29312715/multidisciplinary-approach-to-chest-wall-resection-and-reconstruction-for-chest-wall-tumors-a-single-center-experience
#10
Elisa Scarnecchia, Valeria Liparulo, Alessandra Pica, Giuseppe Guarro, Carmine Alfano, Francesco Puma
Background: Chest wall resection and reconstruction (CWRR) is quite challenging in surgery, due to evolution in techniques. Neoplasms of the chest wall, primary or secondary, have been considered inoperable for a long time. Thanks to evolving surgical techniques, reconstruction after extensive chest wall resection is possible with good functional and aesthetic results. Methods: In our single-center experience, seven cases of extensive CWRR for tumors were performed with a multidisciplinary approach by both thoracic and plastic surgeons...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29306232/evaluation-of-the-effects-of-montelukast-mometasone-furoate-and-combined-therapyon-adenoid-size-a-randomized-prospective-clinical-trial-with-objective-data
#11
Birgül Tuhanıoğlu, Sanem Okşan Erkan
Background/aim: The incidence of adenoid hypertrophy is 2%-3% in children. Adenoidectomy is a commonly performed procedure in children that may cause complications such as early or late bleeding (4%-5%), recurrence of adenoid tissue (10%-20%), and postoperative respiratory problems (27%). Therefore, medical therapy alternatives to adenoidectomy are important and must be tried before surgery. In this study, we investigated the efficacy of mometasone furoate, montelukast, and a combination of these drugs in pediatric patients with adenoid hypertrophy who were scheduled for reduction with medical therapy after not being recommended for surgery...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29301048/spatial-displacement-of-a-lure-component-can-reduce-catches-of-two-nontarget-species-during-spring-monitoring-of-southern-pine-beetle
#12
William P Shepherd, Brian T Sullivan
Local outbreak risk for the southern pine beetle, Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae), is forecast with a trapping survey conducted every spring throughout the southeastern United States. Traps baited with pine odors and components of the D. frontalis aggregation pheromone are used to obtain abundance estimates of both this species and its clerid predator Thanasimus dubius (F.) (Coleoptera: Cleridae); these data are entered into a predictive model that estimates outbreak risk. An attractant synergist for D...
January 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29296761/alternative-donor-hematopoietic-stem-cell-transplantation-for-sickle-cell-disease
#13
Andrew L Gilman, Michael J Eckrich, Stacy Epstein, Carrie Barnhart, Mark Cannon, Tracy Fukes, Michelle Hyland, Krishna Shah, Darci Grochowski, Elizabeth Champion, Anastasia Ivanova
Most patients who could be cured of sickle cell disease (SCD) with stem cell transplantation do not have a matched sibling donor. Successful use of alternative donors, including mismatched family members, could provide a donor for almost all patients with SCD. The use of a reduced-intensity conditioning regimen may decrease late adverse effects. Ten patients with symptomatic SCD underwent CD34+ cell-selected, T-cell-depleted peripheral blood stem cell transplantation from a mismatched family member or unrelated donor...
July 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289957/surgical-treatment-of-cardiac-tumors-insights-from-an-18-year-single-center-analysis
#14
Sabreen Mkalaluh, Marcin Szczechowicz, Saeed Torabi, Bastian Schmack, Anton Sabashnikov, Bashar Dib, Matthias Karck, Alexander Weymann
BACKGROUND The aim of this study was to investigate the clinical presentation, operative data, and early and late outcomes of a large patient cohort undergoing surgical treatment for cardiac tumors in our institution. MATERIAL AND METHODS A total of 181 patients underwent surgery because of suspected cardiac tumor in our institution between 1998 and 2016. In 162 cases, the diagnosis was confirmed postoperatively and these patients were included in this study. Preoperative baseline characteristics, operative data, and postoperative early and long-term outcomes were analyzed...
December 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29286495/early-and-late-radiation-effects-in-healthy-tissues-of-oncologic-patients-under-therapeutic-irradiations
#15
E A Domina
The objective of the article is summarize the literature regarding on the patterns and mechanisms of the formation of early and distant radiation reactions of healthy cells due to the therapeutic irradiation of cancer patients. Particular attention is given to the modern views on the molecular mechanisms of the processes of various repair systems (DDR, BER, NER, MMR, etc.) whose ineffectiveness is associated with radiation induced instability of the genome of healthy cells and the etiology of secondary tumours of radiation genesis in cancer patients as a result of radiation therapy...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29284435/influenza-vaccine-effectiveness-against-influenza-related-hospitalization-during-a-season-with-mixed-outbreaks-of-four-influenza-viruses-a-test-negative-case-control-study-in-adults-in-canada
#16
Melissa K Andrew, Vivek Shinde, Todd Hatchette, Ardith Ambrose, Guy Boivin, William Bowie, Ayman Chit, Gael Dos Santos, May ElSherif, Karen Green, François Haguinet, Scott A Halperin, Barbara Ibarguchi, Jennie Johnstone, Kevin Katz, Joanne M Langley, Jason LeBlanc, Mark Loeb, Donna MacKinnon-Cameron, Anne McCarthy, Janet McElhaney, Allison McGeer, Michaela K Nichols, Jeff Powis, David Richardson, Makeda Semret, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Lingyun Ye, Shelly A McNeil
BACKGROUND: The Serious Outcomes Surveillance (SOS) Network was established to monitor seasonal influenza complications among hospitalized Canadian adults and to assess the effectiveness of influenza vaccination against severe outcomes. Here we report age- and strain-specific vaccine effectiveness (VE) in preventing severe outcomes during a season characterized by mixed outbreaks of four different influenza strains. METHODS: This prospective, multicentre, test-negative case-control study evaluated the VE of trivalent influenza vaccine (TIV) in the prevention of laboratory-confirmed influenza-hospitalization in adults aged ≥16 years (all adults) and adults aged 16-64 years (younger adults)...
December 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29284155/a-retrospective-analysis-comparing-oral-stepdown-therapy-for-enterobacteriaceae-bloodstream-infections-fluoroquinolones-versus-beta-lactams
#17
Nicholas J Mercuro, Patricia Stogsdill, Minkey Wungwattana
Enterobacteriaceae bloodstream infections (EB-BSI) are a common manifestation of Gram-negative sepsis, and are initially managed with empiric intravenous (IV) antibiotics. Upon stabilization and source control, patients are often transitioned to an oral agent. The fluoroquinolone (FQ) class plays a prominent role in stepdown therapy for severe infections due to favorable pharmacokinetic parameters; however, serious adverse effects have been documented with their use. Two hundred and twenty-four adults with EB-BSI initiated on empiric IV antibiotics with stepdown to oral beta-lactam (BLM) (n= 84) or FQ (n= 140) were included to compare clinical success and identify risk factors for treatment failure...
December 25, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29284143/long-term-safety-of-short-term-administration-of-filgrastim-rhg-csf-and-leukophresis-procedure-in-healthy-children-application-of-peripheral-blood-stem-cell-collection-in-pediatric-donors
#18
Maryam Behfar, Sara Faghihi-Kashani, Ashraf Sadat Hosseini, Ardeshir Ghavamzadeh, Amir Ali Hamidieh
INTRODUCTION: Administration of Filgrastim (rhG-CSF) (Neupogen®) in healthy donors to mobilize hematopoietic stem cells (HSC) is a widespread practice in adults. Application of peripheral blood stem cell (PBSC) collection in normal pediatric donors is scarce due to ethical issues. Hence, there are insufficient data on the long-term impact of PBSC procedure in healthy children. This retrospective study aimed to evaluate the early and late adverse effects of PBSC donation in pediatric donors...
December 25, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29283127/rescue-of-failing-or-failed-trabeculectomy-blebs-with-slit-lamp-needling-and-adjunctive-mitomycin-c-in-indian-eyes
#19
Vanita Pathak-Ray, Nikhil Choudhari
PURPOSE: The aim of this study is to investigate the efficacy and safety of needling-revision augmented with a high dose of mitomycin C (MMC) in failing or failed blebs after trabeculectomy in Indian eyes. METHODS: Prospective, noncomparative, interventional study. All patients (>18 years) who had raised intraocular pressure (IOP) following trabeculectomy (>6 weeks and <2 years), who had a flat bleb, bleb encapsulation, and/or required antiglaucoma medication (AGM) for IOP control were eligible for inclusion...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29280859/outcome-analysis-of-free-flap-salvage-in-outpatients-presenting-with-microvascular-compromise
#20
Rene D Largo, Jesse C Selber, Patrick B Garvey, Edward I Chang, Matthew M Hanasono, Peirong Yu, Charles E Butler, Donald P Baumann
BACKGROUND: Extensive flap salvage attempts are routinely performed in patients with late-onset flap vascular crisis despite low flap survival rates. A knowledge gap exists in management of compromised free flaps in patients who present with perfusion-related complications after hospital discharge. METHODS: A retrospective review of 7443 free flaps used in 7128 cancer patients at a single institution from January of 2001 to March of 2015 was performed. RESULTS: Of 7443 free flap reconstructions, 856 patients (12 percent) were taken back to the operating room...
January 2018: Plastic and Reconstructive Surgery
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