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https://www.readbyqxmd.com/read/28641097/long-term-complications-after-hematopoietic-cell-transplantation
#1
REVIEW
Navneet S Majhail
The prevalence of autologous and allogeneic hematopoietic cell transplantation (HCT) survivors continues to increase. Among patients whose disease remains in remission for the first 2-5years after transplantation, it is estimated that approximately 80-90% will be alive over the subsequent 10years. However, the relative mortality rates of such patients continue to remain higher than those of their general population peers, with late complications contributing to significant long-term morbidity and mortality...
June 13, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28636707/incidence-and-predictors-of-opioid-prescription-at-discharge-after-traumatic-injury
#2
Muhammad Ali Chaudhary, Andrew J Schoenfeld, Alyssa F Harlow, Anju Ranjit, Rebecca Scully, Ritam Chowdhury, Meesha Sharma, Stephanie Nitzschke, Tracey Koehlmoos, Adil H Haider
Importance: In the current health care environment with increased scrutiny and growing concern regarding opioid use and abuse, there has been a push toward greater regulation over prescriptions of opioids. Trauma patients represent a population that may be affected by this regulation, as the incidence of pain at hospital discharge is greater than 95%, and opioids are considered the first line of treatment for pain management. However, the use of opioid prescriptions in trauma patients at hospital discharge has not been explored...
June 21, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28634856/estrogen-receptor-%C3%AE-gene-polymorphism-and-vascular-complications-in-girls-with-type-1-diabetes-mellitus
#3
Bartosz Słomiński, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Małgorzata Myśliwiec
The effect of estrogens is mediated by activation of estrogen receptors (ERs). Because ER-α gene polymorphisms may exert different effects in childhood, we analyzed the associations between the IVS1 -397T>C (PvuII) polymorphism and systemic inflammatory state, proangiogenic factors, frequency of monocyte subsets, lipid profile, blood pressure, and vascular complications in girls with type 1 diabetes mellitus (DM1). We examined 180 young girls with DM1 and 120 healthy age-matched controls. The analysis concerned PvuII polymorphism of the ER-α gene as well as the levels of serum inflammatory markers (CRP, IL-6, TNF-α), proangiogenic factors (VEGF, angiogenin), 17β-estradiol, values of monocyte subsets (CD14(++)CD16(-) and CD14(+)CD16(+)), lipid profile, and blood pressure...
June 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28634052/management-of-wide-based-renal-artery-aneurysms-using-noncovered-stent-assisted-coil-embolization
#4
Xiaolong Wei, Yudong Sun, Yani Wu, Zhenjiang Li, Jiang Zhu, Zhiqing Zhao, Rui Feng, Zaiping Jing
OBJECTIVE: This study describes the safety and midterm efficacy of a noncovered stent-assisted embolization (SAE) technique in treating patients with wide-base renal artery aneurysms (RAAs). METHODS: Between February 2011 and June 2014, 34 RAAs in 28 consecutive patients were treated with noncovered SAE in our center. RESULTS: Technical success was 100%. During an average follow-up of 19 months, the systolic and diastolic blood pressures were significantly decreased...
June 17, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28631308/association-between-inadequate-antenatal-care-utilisation-and-severe-perinatal-and-maternal-morbidity-an-analysis-in-the-precare-cohort
#5
M Linard, B Blondel, C Estellat, C Deneux-Tharaux, D Luton, J F Oury, T Schmitz, L Mandelbrot, E Azria
OBJECTIVE: Because the effectiveness of antenatal care in reducing pregnancy complications is still discussed despite widespread recommendations of its use, we sought to assess the association between utilisation of recommended antenatal care and severe maternal (SMM) and perinatal morbidity (SPM). DESIGN: Prospective cohort study. SETTING: Four maternity units around Paris in 2010-2012. SAMPLE: 9117 women with singleton pregnancies...
June 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28628353/effect-of-early-vs-late-start-of-oral-intake-on-anastomotic-leakage-following-elective-lower-intestinal-surgery-a-systematic-review
#6
Boudewijn J J Smeets, Emmeline G Peters, Eelco C J Horsten, Teus J Weijs, Harm J T Rutten, Willem A Buurman, Wouter J de Jonge, Misha D P Luyer
BACKGROUND: Experimental and clinical studies have demonstrated a beneficial effect of early enteral nutrition (EN) on anastomotic leakage following colorectal surgery. Early oral intake is a common form of early EN with various clinical benefits, but the effect on anastomotic leakage is unclear. This systematic review investigates the effect of early vs late start of oral intake on anastomotic leakage following lower intestinal surgery. METHODS: A systematic literature search was performed using the PubMed, Embase, Medline, and Cochrane databases...
June 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28624531/the-short-to-mid-term-symptom-prevalence-of-dumping-syndrome-after-primary-gastric-bypass-surgery-and-its-impact-on-health-related-quality-of-life
#7
Marloes Emous, Bruce H R Wolffenbuttel, Eric Totté, André P van Beek
BACKGROUND: Early and late dumping are complications of gastric bypass surgery. Early dumping occurs within an hour after eating, when the emptying of food into the small intestine triggers rapid fluid shifts into the intestinal lumen and the release of gastrointestinal hormones, resulting in gastrointestinal and vasomotor symptoms. Late dumping occurs between 1 and 3 hours after carbohydrate ingestion and is caused by an exaggerated insulin release, resulting in hypoglycemia. Almost no data are currently available on the prevalence of early and late dumping or their impact on health-related quality of life (QoL)...
April 28, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28624029/effect-of-complications-on-oncologic-outcomes-after-pancreaticoduodenectomy-for-pancreatic-cancer
#8
Anh-Thu Le, Bin Huang, Dima Hnoosh, Hayder Saeed, Sean P Dineen, Peter J Hosein, Eric B Durbin, Mahesh Kudrimoti, Patrick C McGrath, Ching-Wei D Tzeng
BACKGROUND: Although adjuvant therapy (AT) is a necessary component of multimodality therapy for pancreatic ductal adenocarcinoma (PDAC), its application can be hindered by post-pancreaticoduodenectomy (PD) complications. The primary aim of this study was to evaluate the impact of post-PD complications on AT utilization and overall survival (OS). METHODS: Patients undergoing PD without neoadjuvant therapy for stages I-III PDAC at a single institution (2007-2015) were evaluated...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28621638/urologic-complications-after-renal-transplant-a-single-center-experience
#9
Hakan Sözen, Metin Onaran, Onur Özen, Aydın Dalgıç
OBJECTIVES: Urologic complications after kidney transplant are associated with significant morbidity, mortality, and prolonged hospital stay. An intervention or second surgical procedure is frequently required. Here, we report urologic complications in adult kidney recipients. MATERIALS AND METHODS: Since 2006, 171 adult kidney transplant procedures have been performed at the Gazi University Transplantation Center (Ankara, Turkey). Among these patients, there were 65 adult female (38%) and 106 adult male (62%) recipients...
June 16, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28617094/connecting-with-healthcare-providers-at-diagnosis-adolescent-young-adult-cancer-survivors-perspectives
#10
Celeste R Phillips, Joan E Haase, Marion E Broome, Janet S Carpenter, Richard M Frankel
Adolescents and young adults (AYAs) with cancer are a vulnerable and underserved population. AYAs' cancer survivorship is complicated by physical and psychosocial late effects which requires long-term follow-up. Connectedness with healthcare providers (HCPs) is a protective factor that may improve long-term follow-up behaviours of AYAs. However, little is known about AYAs' experiences connecting with HCPs. The purpose of this study was to describe AYA cancer survivors' experiences connecting with HCPs. This empirical phenomenological study interviewed nine AYA cancer survivors diagnosed during adolescence...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28616113/prevention-diagnosis-and-management-of-midurethral-mesh-sling-complications
#11
REVIEW
A Ross Hengel, Kevin V Carlson, Richard J Baverstock
Midurethral slings (MUS) are a proven effective treatment option for stress urinary incontinence (SUI) and have become the gold standard in most centres in North America. MUS implantation can be associated with risks that are common to all anti-incontinence surgeries, and others which are unique. This article reviews the intraoperative and the early and late postoperative risks associated with these procedures, with insights into their prevention, diagnosis, and management drawn from the literature and expert opinion...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28615812/optimising-aesthetic-outcome-after-nipple-areola-complex-sparing-mastectomy-and-immediate-one-stage-prosthetic-reconstruction-a-simple-surgical-trick-to-fix-nipple-areola-complex-position
#12
Luca Maione, Andrea Lisa, Federico Barbera, Mattia Siliprandi, Valeriano Vinci, Francesco Klinger, Marco Klinger
BACKGROUND: Nipple-areola complex (NAC) sparing mastectomy (NSM) is mostly indicated in patients with small-/medium-sized and non-ptotic breasts, while skin-reducing mastectomy is used in patients with medium or large breasts with severe ptosis. NAC location on the reconstructed breast is one of the major factors in determining the final aesthetic result and patients' satisfaction. An optimum result obtained at the end of surgical procedure may be altered and compromised by skin redistribution and consequently NAC depositioning during the post-operative period in patients with medium-sized breasts and a moderate degree of ptosis...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28613398/fetal-and-umbilical-doppler-ultrasound-in-high-risk-pregnancies
#13
REVIEW
Zarko Alfirevic, Tamara Stampalija, Therese Dowswell
BACKGROUND: Abnormal blood flow patterns in fetal circulation detected by Doppler ultrasound may indicate poor fetal prognosis. It is also possible that false positive Doppler ultrasound findings could lead to adverse outcomes from unnecessary interventions, including preterm delivery. OBJECTIVES: The objective of this review was to assess the effects of Doppler ultrasound used to assess fetal well-being in high-risk pregnancies on obstetric care and fetal outcomes...
June 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28609013/polydatin-alleviated-radiation-induced-lung-injury-through-activation-of-sirt3-and-inhibition-of-epithelial-mesenchymal-transition
#14
Kun Cao, Xiao Lei, Hu Liu, Hainan Zhao, Jiaming Guo, Yuanyuan Chen, Yang Xu, Ying Cheng, Cong Liu, Jianguo Cui, Bailong Li, Jianming Cai, Fu Gao, Yanyong Yang
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti-inflammation and anti-oxidative capacities in other diseases. In this study, we demonstrated that PD-mitigated acute inflammation and late fibrosis caused by irradiation. PD treatment inhibited TGF-β1-Smad3 signalling pathway and epithelial-mesenchymal transition...
June 13, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28605260/cellular-therapies-for-treatment-of-radiation-injury-report-from-a-nih-niaid-and-irsn-workshop
#15
Andrea L DiCarlo, Radia Tamarat, Carmen I Rios, Marc Benderitter, Christine W Czarniecki, Theresa C Allio, Francesca Macchiarini, Bert W Maidment, Jean-Rene Jourdain
In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there exists the real possibility that safety of nuclear power reactors could be compromised by natural (such as the tsunami and subsequent Fukushima accident in Japan in March, 2011) or accidental (Three Mile Island, 1979 and Chernobyl, 1986) events...
June 12, 2017: Radiation Research
https://www.readbyqxmd.com/read/28603716/optimizing-nutrition-in-preterm-low-birth-weight-infants-consensus-summary
#16
REVIEW
R Kishore Kumar, Atul Singhal, Umesh Vaidya, Saswata Banerjee, Fahmina Anwar, Shashidhar Rao
Preterm birth survivors are at a higher risk of growth and developmental disabilities compared to their term counterparts. Development of strategies to lower the complications of preterm birth forms the rising need of the hour. Appropriate nutrition is essential for the growth and development of preterm infants. Early administration of optimal nutrition to preterm birth survivors lowers the risk of adverse health outcomes and improves cognition in adulthood. A group of neonatologists, pediatricians, and nutrition experts convened to discuss and frame evidence-based recommendations for optimizing nutrition in preterm low birth weight (LBW) infants...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28601872/il-37-causes-excessive-inflammation-and-tissue-damage-in-murine-pneumococcal-pneumonia
#17
Anja E Schauer, Tilman E Klassert, Carolin von Lachner, Diana Riebold, Anne Schneeweiß, Magdalena Stock, Mario M Müller, Sven Hammerschmidt, Philip Bufler, Ulrike Seifert, Kristina Dietert, Charles A Dinarello, Marcel F Nold, Achim D Gruber, Claudia A Nold-Petry, Hortense Slevogt
Streptococcus pneumoniae infections can lead to severe complications with excessive immune activation and tissue damage. Interleukin-37 (IL-37) has gained importance as a suppressor of innate and acquired immunity, and its effects have been therapeutic as they prevent tissue damage in autoimmune and inflammatory diseases. By using RAW macrophages, stably transfected with human IL-37, we showed a 70% decrease in the cytokine levels of IL-6, TNF-α, and IL-1β, and a 2.2-fold reduction of the intracellular killing capacity of internalized pneumococci in response to pneumococcal infection...
June 10, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28600745/safety-and-effectiveness-of-gold-glaucoma-micro-shunt-for-reducing-intraocular-pressure-in-japanese-patients-with-open-angle-glaucoma
#18
Masaki Tanito, Etsuo Chihara
PURPOSE: To assess the safety and effectiveness of the SOLX gold shunt (GS) in reducing intraocular pressure (IOP) in Japanese patients with open angle glaucoma (OAG). METHODS: 24 eyes of 24 subjects [mean age of 68.9 ± 12.7 years; 13 (54%) women; 16 (67%) POAG, 7 (29%) pseudoexfoliation glaucoma, and 1 (4%) steroid response glaucoma] were implanted with the GS either with or without cataract surgery. Best-corrected visual acuity (BCVA), IOP, corneal endothelial cell density (CECD), anterior chamber (AC) flare, surgical complications, and required interventions were monitored at baseline, and 1 day, 1 week, 1, 3 and 6 months, and 1 year postoperatively...
June 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28595772/prevention-of-early-complications-and-late-consequences-after-acute-pulmonary-embolism-focus-on-reperfusion-techniques
#19
Stavros V Konstantinides, Stefano Barco
Pulmonary embolism (PE) is a major cause of acute cardiovascular mortality and long-term morbidity. Right ventricular (RV) dysfunction is the key determinant of prognosis in the acute phase of PE, and residual RV dysfunction is associated with the development of post-PE functional impairment, chronic thromboembolic disease, and higher costs of treatment over the long term. Patients with clinically overt RV failure, i.e. hemodynamic collapse at presentation (high-risk PE), necessitate immediate thrombolytic treatment to relieve the obstruction in the pulmonary circulation; surgical or catheter-directed removal of the thrombus can be an alternative option...
June 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28591805/two-della-interacting-proteins-bhlh48-and-bhlh60-regulate-flowering-under-long-day-conditions-in-arabidopsis-thaliana
#20
Yang Li, Houping Wang, Xiaoli Li, Gang Liang, Diqiu Yu
Gibberellin (GA) regulates many developmental transitions in the plant life cycle. Although great progress has been made, the GA signaling pathways have not been fully elucidated. Identifying and characterizing new targets of DELLA proteins is an effective approach to reveal the complicated GA signaling networks. In this study, two novel DELLA-interacting transcription factors, bHLH48 and bHLH60, were identified. Their overexpression caused plants to flower early under long-day conditions, whereas their functional repression resulted in the opposite result...
June 7, 2017: Journal of Experimental Botany
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