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https://www.readbyqxmd.com/read/29145315/iodine-125-seed-implantation-for-synchronous-pancreatic-metastases-from-hepatocellular-carcinoma-a-case-report-and-literature-review
#1
Junjie Xiong, Selina Kwong Chian, Jiao Li, Xubao Liu
RATIONALE: The image-guided iodine-125 seed implantation has been widely used for a variety of tumors, including prostatic cancer, pulmonary cancer, hepatocellular carcinoma and pancreatic cancer. However, the clinical value of iodine-125 seed implantation for the treatment of pancreatic metastasis from hepatocellular carcinoma has not been reported. We presented the first case with ultrasound-guided iodine-125 seed implantation for this disease. PATIENT CONCERNS: We presented the case of a 48-year-old man patient with primary hepatocellular carcinoma and pancreatic metastasis who was managed with ultrasound-guided iodine-125 seeds implantation...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145240/gastrointestinal-stromal-tumor-gist-with-liver-metastases-an-18-year-experience-from-the-gist-cooperation-group-in-north-china
#2
Yi-Nan Shi, Yong Li, Li-Ping Wang, Zhen-Hua Wang, Xiao-Bo Liang, Han Liang, Li Zhang, Bin Li, Li-Qiao Fan, Qun Zhao, Zhi-Xue Ma, Xue-Feng Zhao, Zhi-Dong Zhang, Yu Liu, Bi-Bo Tan, Dong Wang, Li-Li Wang, Ying-Jie Hao, Nan Jia
Approximately 40% to 50% of gastrointestinal stromal tumor (GIST) patients will have recurrence or metastases after resection of the primary lesion, and the most common affected sites will be liver and peritoneum. Imatinib has been considered as the first-line therapy of metastatic GIST. Surgery for metastases is proposed when possible. Furthermore, there are controversies concerning hepatic resection and systemic tyrosin kinase inhibitors (TKIs). The therapeutic conditions and long-term outcome of GIST patients with liver metastases in northern China remain unknown...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29139084/common-hepatic-artery-abutment-or-encasement-is-an-adverse-prognostic-factor-in-patients-with-borderline-and-unresectable-pancreatic-cancer
#3
Geoffrey M Kozak, Jeffrey D Epstein, Sandeep P Deshmukh, Benjamin B Scott, Scott W Keith, Harish Lavu, Charles J Yeo, Jordan M Winter
BACKGROUND: Localized and unresectable pancreatic ductal adenocarcinoma (PDA) comprises one third of new diagnoses and includes borderline resectable (BR) and locally advanced (LA) unresectable disease. In a cohort of patients who were treated and followed at a single institution, we assessed clinical and radiographic predictors of outcome. METHODS: The study included 69 consecutive patients with BR or LA PDA. Serial imaging studies were reviewed by both a pancreatic surgeon and a radiologist for vascular abutment or encasement by cancer, and they were recorded...
November 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29138811/high-expression-of-mage-a9-contributes-to-stemness-and-malignancy-of-human-hepatocellular-carcinoma
#4
Youping Wei, Yanqin Wang, Jing Gong, Lihua Rao, Zhiwei Wu, Teng Nie, Dongling Shi, Liming Zhang
MAGE-A9, a well-characterized cancer testis antigen (CTA), belongs to a member of melanoma antigen gene (MAGE) family. In human malignancies, aberrant expression of MAGE genes correlated with poor clinical prognosis, increased tumor growth, metastases, and enrichment in stem cell populations of certain cancers. Cancer stem cells (CSCs) have been proposed to contribute to the major malignant phenotypes of liver cancer, including recurrence, metastasis and chemoresistance. However, expression and potential role of MAGE-A9 in liver cancer stem cells (LCSCs) still remain unclear...
November 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29135843/abscessing-infection-by-streptococcus-mitis-mimicking-metastatic-lesions-in-a-5-year-old-girl-with-nephroblastoma-a-case-report
#5
Lara Imhof, Simone Schrading, Till Braunschweig, Gerhard Steinau, Jan Wilhelm Spillner, Alexander Puzik, Lisa Lassay, Udo Kontny
Streptococcus mitis is a common pathogen causing infections in oncological patients. However, cases of abscesses caused by Streptococcus mitis in oncological patients have not been reported so far. We report on 5-year-old child with nephroblastoma and pulmonary and hepatic metastases at diagnosis who went into complete remission undergoing chemotherapy and nephrectomy, and who developed new round lesions in liver and lungs under continuous chemotherapy suggestive of new metastases. Biopsy of the lesions revealed abscesses with detection of Streptococcus mitis...
November 13, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29122287/radiologic-and-histopathologic-correlation-of-different-growth-patterns-of-metastatic-uveal-melanoma-to-the-liver
#6
Albert Liao, Pardeep Mittal, David H Lawson, Jenny J Yang, Eszter Szalai, Hans E Grossniklaus
PURPOSE: The purpose of this study was to correlate magnetic resonance imaging (MRI) radiographic results with histopathologic growth patterns of metastatic uveal melanoma (UM) to the liver. DESIGN: Clinicopathologic correlation. PARTICIPANTS: Patients with metastatic UM to the liver. METHODS: A retrospective review of MRI images of patients with metastatic UM to the liver at a single institution between 2004 and 2016 was performed...
November 6, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29120905/fluorine-18-fluorodeoxyglucose-uptake-of-bone-marrow-on-pet-ct-can-predict-prognosis-in-patients-with-colorectal-cancer-after-curative-surgical-resection
#7
Jeong Won Lee, Moo-Jun Baek, Tae Sung Ahn, Sang Mi Lee
OBJECTIVE: This study investigated the relationship of fluorine-18-fluorodeoxyglucose (F-FDG) uptake of bone marrow (BM) on PET/computed tomography (PET/CT) with clinicopathologic factors and survival in patients with colorectal cancer. PATIENTS AND METHODS: The study retrospectively included 226 patients with colorectal cancer who underwent F-FDG PET/CT for staging workup and treated with curative surgical resection. The maximum F-FDG uptake of primary cancer (Tmax) and mean F-FDG uptake of BM [BM standardized uptake value (SUV)] were derived from PET/CT images...
November 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29115095/radiologic-findings-in-extrapancreatic-solid-pseudopapillary-tumor-with-aggressive-behavior-a-case-report
#8
Hye Won Choi, Hyun Jeong Park, Soon Auk Hong, Sung Bin Park, Eun Sun Lee, Hye Shin Ahn, Jong Beum Lee, Byung Ihn Choi
Solid pseudopapillary tumor (SPT) is a low grade malignant tumor in the pancreas, and extrapancreatic SPT is extremely rare. We report a case of a 61-year-old woman who complained abdominal pain with diffuse tenderness. She was diagnosed with extrapancreatic SPT with extensive peritoneal dissemination and hepatic metastases. Although a few cases have reported imaging findings of extrapancreatic SPT, there have been no reports of extrapancreatic SPT with aggressive tumor behavior and dismal prognosis. Although imaging features closely resembled those of classical pancreatic SPTs, malignant transformation of extrapancreatic SPT should be considered when focal discontinuity of the tumor capsule with ill-defined margin and invasion of adjacent structures were identified...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29113730/conversion-to-resection-in-patients-receiving-systemic-chemotherapy-for-unresectable-and-or-metastatic-colorectal-cancer-predictive-factors-and-prognosis
#9
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Kazuhito Sasaki, Manabu Kaneko, Koji Murono
BACKGROUND: Systemic chemotherapy increases the possibility of resection in patients with initially unresectable colorectal cancer (CRC), especially patients with hepatic metastasis. However, the predictive factors and prognosis of conversion to resection after chemotherapy in patients with various organ metastases remain largely unknown. PATIENTS AND METHODS: We reviewed the data from metastatic CRC (mCRC) patients who had received oxaliplatin- or irinotecan-based systemic chemotherapy from 2005 to 2016...
October 19, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29113675/surgery-induced-tumor-growth-in-metastatic-colorectal-cancer
#10
REVIEW
Klaas M Govaert, Jennifer M J Jongen, Onno Kranenburg, Inne H M Borel Rinkes
Metastatic colorectal cancer (mCRC) is a devastating disease causing 700.000 deaths annually worldwide. Metastases most frequently develop in the liver. Partial hepatectomy has dramatically improved clinical outcome and is the only curative treatment option for eligible patients with mCRC. Pre-clinical studies have shown that surgical procedures can have tumor-promoting local 'side-effects' such as hypoxia and inflammation, thereby altering the behaviour of residual tumor cells. In addition, systemically released factors following (colon or liver) surgery can act as a wakeup-call for dormant tumor cells in distant organs and/or help establish a pre-metastatic niche...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113650/laparoscopic-parenchymal-preserving-liver-resections-for-colorectal-liver-metastases-in-the-era-of-highly-effective-systemic-therapy-and-selective-internal-radiation-therapy-can-often-prevent-a-hemihepatectomy-with-video
#11
Mathieu D'Hondt, Frédéric Ververken, Frederiek Nuytens
BACKGROUND: Preservation of hepatic parenchyma is important in liver surgery to prevent postoperative liver failure and according to some reports it could offer a prolonged survival and lower recurrence rates compared to major hepatectomies in patients with colorectal liver metastases. However, laparoscopic parenchyma-preserving liver resections can be technically challenging. The aim of this video is to illustrate the concept of laparoscopic parenchymal-preserving liver resections after conversion chemotherapy with targeted therapy...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113384/subclinical-involvement-of-the-liver-is-associated-with-prognosis-in-treatment-na%C3%A3-ve-cancer-patients
#12
Noemi Pavo, Markus Raderer, Georg Goliasch, Raphael Wurm, Guido Strunk, Anna Cho, Johannes F Novak, Heinz Gisslinger, Günther G Steger, Michael Hejna, Wolfgang Köstler, Sabine Zöchbauer-Müller, Christine Marosi, Gabriela Kornek, Leo Auerbach, Sven Thorben Schneider, Bernhard Parschalk, Werner Scheithauer, Robert Pirker, Barbara Kiesewetter, Richard Pacher, Christoph Zielinski, Martin Hülsmann
Background: Routinely tested liver biomarkers as alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), butyryl-cholinesterase (BChE), albumin and bilirubin are altered in distinct malignancies and hepatic metastases. This study aimed to investigate whether all liver parameters have the ability to predict long-term mortality in treatment naïve cancer patients but without a malignant hepatic involvement. Methods: We prospectively enrolled 555 consecutive patients with primary diagnosis of cancer without prior anticancer therapy...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113001/the-impact-of-high-end-ultrasound-in-the-management-of-a-patient-with-neuroendocrine-tumor-of-the-ileum
#13
Tatjana Schmidt, Julia M Schwarz, Martina Steurer, Martin Goetz, Susann-Cathrin Olthof, Nisar P Malek, Bita Boozari
Diagnostic imaging of jejuno-ileal neuroendocrine tumors (NETs) has been described as challenging. Follow-up requires the detection of metastatic spread as well as screening for local recurrence. Multimodal imaging concepts must often be applied.We report the case of a 45-year-old man with a history of ileal NET. At 2 points in follow-up of our patient, information provided by high-end ultrasound changed prognosis and treatment considerably: when positron emission tomography/computed tomography newly detected suspected hepatic metastases, contrast-enhanced ultrasound correctly identified the lesions as intrahepatic vascular shunts...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29110841/heterogeneous-resistance-mechanisms-in-an-egfr-exon-19-mutated-non-small-cell-lung-cancer-patient-treated-with-erlotinib-persistent-fgfr3-mutation-localized-transformation-to-egfr-mutated-sclc-and-acquired-t790m-egfr-mutation
#14
Eric Santoni-Rugiu, Morten Grauslund, Linea C Melchior, Junia C Costa, Jens B Sørensen, Edyta M Urbanska
Patients with epidermal growth factor receptor (EGFR) gene-mutated non-small cell lung cancer (NSCLC) obtain substantial clinical benefit from EGFR tyrosine-kinase inhibitors (TKIs), but will ultimately develop TKI-resistance resulting in median progression-free survival of 9-15 months during first-line TKI-therapy. However, type and timing of TKI-resistance cannot be predicted and several mechanisms may simultaneously/subsequently occur during TKI-treatment. In this respect, we present a 49 year-old Caucasian male ex-smoker with metastatic pulmonary adenocarcinoma (ADC) that concomitantly harbored an EGFR exon 19-mutation (p...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29107103/long-noncoding-rna-linc00675-enhances-phosphorylation-of-vimentin-on-ser83-to-suppress-gastric-cancer-progression
#15
Shuo Zeng, Xia Xie, Yu-Feng Xiao, Bo Tang, Chang-Jiang Hu, Shu-Ming Wang, Yu-Yun Wu, Hui Dong, Bo-Sheng Li, Shi-Ming Yang
Long noncoding RNAs (lncRNAs) play a crucial role in cancer development, but few lncRNAs have been functionally characterized in gastric cancer (GC). Here, we reported an lncRNA LINC00675 whose expression was significantly decreased in GC tissues compared with the adjacent non-tumor tissues, and its low expression was associated with the poor survival of GC patients. Gain-and loss-of-function studies indicated that LINC00675 was a tumor suppressor because it repressed the proliferation, migration and invasion of GC cells in vitro and also inhibited the distal pulmonary and hepatic metastases of GC cells in vivo...
October 26, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29102861/an-isolated-metachronous-metastasis-to-the-adrenal-gland-from-a-pancreatic-neuroendocrine-tumor-a-case-report
#16
Yasunaru Sakuma, Naohiro Sata, Kazuhiro Endo, Yoshikazu Yasuda, Shinichiro Yokota, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyoshi Fukushima, Shoko Asakawa, Yuuki Kawarai Shimada, Chieko Kawarai Lefor, Alan Kawarai Lefor
INTRODUCTION: Pancreatic neuroendocrine tumors are rare. Treatment includes aggressive local management of the primary lesion and metastases, and systemic somatostatin. This is the first report of an isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor that presented 90 months after the primary tumor. PRESENTATION OF CASE: The patient presented as a 53yo man with a left upper quadrant mass and synchronous metastases to the spleen and liver (pancreatic neuroendocrine tumor T4N0M1, Stage IV), which were resected (CD56-, synaptophysin+, chromogranin+, Ki-67<1%)...
October 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29098384/prognostic-influence-of-hepatic-margin-after-resection-of-colorectal-liver-metastasis-role-of-modern-preoperative-chemotherapy
#17
Frank Makowiec, Peter Bronsert, Andrea Klock, Ulrich T Hopt, Hannes P Neeff
PURPOSE: Modern chemotherapy (CTX) increases survival in stage IV colorectal cancer. In colorectal liver metastases (CLM), neoadjuvant (neo) CTX may increase resectability and improve survival. Due to widespread use of CTX in CLM, recent studies assessed the role of the hepatic margin after CTX, with conflicting results. We evaluated the outcome after resection of CLM in relation to CTX and hepatic resection status. METHODS: Since 2000, 334 patients with first hepatic resection for isolated CLM were analyzed...
November 2, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29084013/ring-like-enhancement-of-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-multiphasic-hepatic-arterial-phase-imaging-with-differential-subsampling-with-cartesian-ordering
#18
Shintaro Ichikawa, Utaroh Motosugi, Naoki Oishi, Tatsuya Shimizu, Tetsuya Wakayama, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate the efficacy of multiphasic hepatic arterial phase (HAP) imaging using DISCO (differential subsampling with Cartesian ordering) in increasing the confidence of diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed patient consent was waived. Consecutive patients (from 2 study periods) with malignant liver nodules were examined by gadoxetic acid-enhanced magnetic resonance imaging using either multiphasic (6 phases; n = 135) or single (n = 230) HAP imaging, which revealed 519 liver nodules other than benign ones (HCC, 497; cholangiocarcinoma, 11; metastases, 10; and malignant lymphoma, 1)...
October 27, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29081375/dose-surgical-resection-of-hepatic-metastases-bring-benefits-to-pancreatic-ductal-adenocarcinoma-a-systematic-review-and-meta-analysis
#19
REVIEW
Xinzhe Yu, Jichun Gu, Deliang Fu, Chen Jin
OBJECTIVE: The objectives of this systematic review and meta-analysis were to examine morbidity, mortality, and long-term survival after surgical resection of hepatic metastases from pancreatic ductal adenocarcinoma (PDAC) patients. BACKGROUND: Patients with hepatic metastases from pancreatic ductal adenocarcinoma are facing a dilemma of whether to make hepatic resection. METHODS: A systematic literature research was undertaken through computerized databases as well as manually research from unpublished data...
November 2, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29076951/cisplatin-dacarbazine-and-vinblastine-as-first-line-chemotherapy-for-liver-metastatic-uveal-melanoma-in-the-era-of-immunotherapy-a-single-institution-phase-ii-study
#20
Giovanni Schinzari, Ernesto Rossi, Alessandra Cassano, Vincenzo Dadduzio, Michela Quirino, Monica Pagliara, Maria A Blasi, Carlo Barone
No standard therapy is established for metastatic uveal melanoma. Liver involvement in uveal melanoma may lead to organ impairment, which represents a common cause of death. Tumor shrinkage might improve survival by delaying hepatic failure. Since the combination of cisplatin, vinblastine, dacarbazine allowed a high response rate in metastatic cutaneous melanoma, we explored efficacy and safety of this regimen in unresectable liver metastases of uveal melanoma. In the present phase II study we administered intravenously cisplatin (80 mg/mq, day 1), dacarbazine (250 mg/mq/day, days 1-3), vinblastine (2 mg maximum, day 1) every 21 days as first line treatment for patients with unresectable metastases of uveal melanoma and BRAF wild type...
December 2017: Melanoma Research
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