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Hepatic metastases

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https://www.readbyqxmd.com/read/29780653/isolated-superior-mesenteric-vein-tumor-thrombus-in-a-patient-with-gastric-cancer
#1
Barış Özcan, Metin Çevener, Ayşegül Kargı, Mustafa Özdoğan, Alihan Gürkan
Tumor thrombus in the portal vein can rarely originate from gastric cancer via hematogenous spread, with only few case reports published in the literature. Isolated superior mesenteric vein tumor thrombus in gastric cancer has not been previously reported. A 61-year-old male patient who had undergone distal gastrectomy and gastroenterostomy for gastric ulcer 20 years ago was diagnosed with an obstructive tumor originating from the gastroenterostomy anastomosis site on upper gastrointestinal endoscopy that was performed for complaints of fatigue, oral feeding problems, and anemia...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29767820/-role-of-visceral-surgery-in-oligometastases-of-non-gastrointestinal-tumors
#2
REVIEW
R Wahba, D Stippel, C Bruns
BACKGROUND: Patients with oligometastatic disease can benefit from local treatment of the metastases. Under these premises the resection of liver metastases and visceral metastases of non-gastrointestinal tumors is performed increasingly more frequently in selected patients. The aim of this study was to evaluate the role of visceral oncological surgery in hepatic oligometastatic disease of non-gastrointestinal tumors according to the currently available literature. MATERIAL AND METHODS: A systematic search of MEDLINE and PubMed was carried out focusing on the topics of oligometastases, liver resection and metastectomy for breast cancer, renal cell carcinoma, malignant melanoma, ovarian cancer and non-small cell lung cancer...
May 16, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29763717/hepatic-micrometastases-are-associated-with-poor-prognosis-in-patients-with-liver-metastases-from-neuroendocrine-tumors-of-the-digestive-tract
#3
William E Gibson, Raul S Gonzalez, Justin M M Cates, Eric Liu, Chanjuan Shi
Pathologic examination of hepatic metastasectomies from patients with metastatic small intestinal or pancreatic neuroendocrine tumor frequently reveals micrometastases undetectable by radiologic or macroscopic gross examination. This finding raises the possibility that undetectable micrometastases remain in these patients after metastasectomy. Here we examined liver resections for micrometastases and assessed their impact on prognosis. Hepatic metastasectomies from 65 patients with neuroendocrine tumor of the small intestine (N=43) or pancreas (N=22) were reviewed for the presence of micrometastases, which were defined as microscopic tumor foci ≤1mm in greatest dimension...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29762236/acute-pancreatitis-following-peptide-receptor-radionuclide-therapy-an-unusual-adverse-event
#4
Ioannis Karfis, Gwennaëlle Marin, Godelieve Machiels, Alain Hendlisz, Patrick Flamen
A 54-year-old man with grade 2 rectal neuroendocrine tumor and hepatic, pancreatic, and bone metastases was treated with Lu-DOTATATE as second-line therapy, after failure of somatostatin analogues. Two weeks after the first injection, he presented at the emergency department with acute pancreatitis. We hypothesized that this unusual adverse event, never been reported so far, was the result of acute tumor irradiation after PRRT, leading to peritumoral inflammation and edema with obstruction of an accessory pancreatic duct...
May 14, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29760793/hepatitis-b-virus-infection-predicts-better-survival-in-patients-with-colorectal-liver-only-metastases-undergoing-liver-resection
#5
Yujie Zhao, Junzhong Lin, Jianhong Peng, Yuxiang Deng, Ruixia Zhao, Qiaoqi Sui, Zhenhai Lu, Desen Wan, Zhizhong Pan
Objective: Hepatitis B virus (HBV) infection has been shown to decrease the risk of liver metastasis in patients with non-metastatic colorectal cancer (CRC). However, the prognostic value of HBV infection in long-term survival of patients with colorectal liver-only metastases (CRLM) after liver resection has not yet been evaluated. This study aims to explore the association between HBV infection and survival in CRLM patients. Methods: A total of 289 CRLM patients undergoing liver resection were recruited at our center from September 1999 to August 2015...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29755770/safety-and-initial-efficacy-of-radiation-segmentectomy-for-the-treatment-of-hepatic-metastases%C3%A2
#6
Craig Meiers, Amy Taylor, Brian Geller, Beau Toskich
Background: Hepatic metastatectomy and ablation are associated with prolonged survival, but not all lesions are anatomically amenable to these therapies. We evaluated safety and initial efficacy of segmental ablative transarterial radioembolization, or radiation segmentectomy (RS), as a treatment for hepatic metastases. Methods: A single institution retrospective analysis was performed of patients with hepatic metastases, determined unamenable to resection by a multidisciplinary tumor board, treated with RS from 2015-2017...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29754852/predictors-of-survival-after-yttrium-90-radioembolization-for-colorectal-cancer-liver-metastases
#7
Ashley A Weiner, Bin Gui, Neil B Newman, John L Nosher, Fady Yousseff, Shou-En Lu, Gretchen M Foltz, Darren Carpizo, Jonathan Lowenthal, Darryl A Zuckerman, Ben Benson, Jeffrey R Olsen, Salma K Jabbour, Parag J Parikh
PURPOSE: To identify clinical parameters that are prognostic for improved overall survival (OS) after yttrium-90 radioembolization (RE) in patients with liver metastases from colorectal cancer (CRC). MATERIALS AND METHODS: A total of 131 patients who underwent RE for liver metastases from CRC, treated at 2 academic centers, were reviewed. Twenty-one baseline pretreatment clinical factors were analyzed in relation to OS by the Kaplan-Meier method along with log-rank tests and univariate and multivariate Cox regression analyses...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29751969/the-rate-of-false-positive-diagnosis-of-colorectal-liver-metastases-in-patients-undergoing-resection-with-the-development-of-a-novel-externally-validated-risk-score
#8
David J O'Reilly, James Hodson, Thomas W Pike, Ravi Marudanayagam, Robert P Sutcliffe, Paolo Muiesan, John Isaac, J Peter A Lodge, Darius F Mirza, Keith J Roberts
BACKGROUND: Diagnostic error in patients undergoing resection of colorectal liver metastases (CRLM) is unusual but exposes patients to unnecessary risks associated with treatment. The primary aim of this study was to determine the rate of and risk factors for a false-positive diagnosis of colorectal liver metastases in patients undergoing hepatic resection. The secondary aim was to develop and validate a risk score to predict a false-positive diagnosis. METHODS: Patients were identified from prospectively maintained databases...
May 8, 2018: Surgery
https://www.readbyqxmd.com/read/29750133/use-of-indirect-target-gating-in-magnetic-resonance-guided-liver-stereotactic-body-radiotherapy-case-report-of-an-oligometastatic-patient
#9
Luca Boldrini, Francesco Cellini, Stefania Manfrida, Giuditta Chiloiro, Stefania Teodoli, Davide Cusumano, Bruno Fionda, Gian Carlo Mattiucci, Anna Maria De Gaetano, Luigi Azario, Vincenzo Valentini
The case of a 73-year-old woman affected by anal canal cancer with concomitant liver metastases is presented here. The patient was addressed to stereotactic body radiotherapy (SBRT) on two hepatic secondary lesions after the first radiochemotherapy treatment of the primary tumor. A Tri-60-Co magnetic resonance hybrid radiotherapy unit was used for SBRT treatment delivery. Both liver lesions were not clearly visible on the setup magnetic resonance imaging (MRI) due to their limited dimensions (maximum diameter 13 mm); however, the presence of two cysts adjacent to the metastases allowed the use of an indirect target gating approach...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29744349/primary-lymph-node-ratio-and-hepatic-resection-for-colorectal-metastases
#10
EDITORIAL
Daniel Ansari, William Torén, Roland Andersson
No abstract text is available yet for this article.
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29743050/unmasking-of-intracranial-metastatic-melanoma-during-ipilimumab-nivolumab-therapy-case-report-and-literature-review
#11
Marin A McDonald, Parag Sanghvi, Julie Bykowski, Gregory A Daniels
BACKGROUND: While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in the context of immunotherapeutic treatment of intracranial disease. Here we report two independent cases of new intracranial metastases presenting after initiation of combined checkpoint blockade Ipilimumab and Nivolumab for recurrent metastatic melanoma in the context of positive systemic disease response...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29736851/towards-volumetric-thresholds-in-recist-1-1-therapeutic-response-assessment-in-hepatic-metastases
#12
Katharina S Winter, Felix O Hofmann, Kolja M Thierfelder, Julian W Holch, Nina Hesse, Alena B Baumann, Dominik P Modest, Sebastian Stintzing, Volker Heinemann, Jens Ricke, Wieland H Sommer, Melvin D'Anastasi
OBJECTIVES: To empirically determine thresholds for volumetric assessment of response and progress of liver metastases in line with the unidimensional RECIST thresholds. METHODS: Patients with metastatic colorectal cancer initially enrolled in a multicentre clinical phase-III trial were included. In all CT scans, the longest axial diameters and volumes of hepatic lesions were determined semi-automatically. The sum of diameters and volumes of 1, ≤2 and ≤5 metastases were compared to all previous examinations...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29736846/diagnostic-accuracy-of-ce-ct-mri-and-fdg-pet-ct-for-detecting-colorectal-cancer-liver-metastases-in-patients-considered-eligible-for-hepatic-resection-and-or-local-ablation
#13
Kim Sivesgaard, Lars P Larsen, Michael Sørensen, Stine Kramer, Sven Schlander, Nerijus Amanavicius, Arindam Bharadwaz, Dennis Tønner Nielsen, Frank Viborg Mortensen, Erik Morre Pedersen
PURPOSE: To compare the diagnostic performance of contrast-enhanced computed tomography (CE-CT), magnetic resonance imaging (MRI) and combined fluorodeoxyglucose/positron emission tomography/computed tomography (FDG-PET/CT) for detection of colorectal liver metastases (CRLM) in patients eligible for local treatment. MATERIALS AND METHODS: This health-research ethics-committee-approved prospective consecutive diagnostic accuracy study, with written informed consent, included 80 cases (76 patients, four participating twice) between 29 June 2015 and 7 February 2017...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29736626/regional-therapies-for-locoregionally-advanced-and-unresectable-melanoma
#14
Evan S Weitman, Jonathan S Zager
Locoregionally advanced and unresectable disease can be seen in up to 10% of melanoma patients. Treatment options for these patients have been evolving most notably over the past few decades and have demonstrated efficacy through multiple intra-arterial as well as intralesional therapies. Isolated limb perfusions and isolated limb infusions have been utilized to treat locoregionally advanced melanoma of the extremity with overall response rates up to 90% in some reports. Intralesional therapies, for in transit metastatic melanoma, such as Bacille Calmette-Guerin, talimogene laherparepvec, and PV-10 (Rose Bengal) have all demonstrated efficacy in the treatment of unresectable cutaneous melanoma...
May 8, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29731866/microrna-hsa-let-7e-5p-as-a-potential-prognosis-marker-for-rectal-carcinoma-with-liver-metastases
#15
Wenfeng Chen, Guosheng Lin, Yizhou Yao, Jishen Chen, Hanli Shui, Qinghai Yang, Xiaoya Wang, Xiaoyuan Weng, Ling Sun, Fei Chen, Sheng Yang, Yufeng Yang, Yongjian Zhou
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that target mRNAs for translational repression or cleavage. The present study was conducted to identify differentially expressed miRNAs in primary tumor tissues of rectal carcinoma (RC) that may be associated with heterochrony hepatic metastasis (HHM). Samples were collected exclusively from patients with RC but not colon cancer (CC); Next-generation high-throughput sequencing technology and bioinformatics tools were used to profile and analyze small RNAs and their corresponding targets in primary tumor tissues with HHM (n=2) or without metastases (non-metastatic, NM; n=2)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29725401/rapid-progression-of-a-granulocyte-colony-stimulating-factor-producing-liver-tumor-metastasized-from-esophagogastric-junction-cancer-a-case-report-and-literature-review
#16
Sojun Hoshimoto, Nobuo Hoshi, Iwao Ozawa, Moriaki Tomikawa, Hirofumi Shirakawa, Takeshi Fujita, Saho Wakamatsu, Sayuri Hoshi, Kaoru Hirabayashi, Shoichi Hishinuma, Yoshiro Ogata
The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony-stimulating factor (G-CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post-operative day the patient's leukocyte count and serum G-CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29724520/long-term-toxicity-after-transarterial-radioembolization-with-yttrium-90-using-resin-microspheres-for-neuroendocrine-tumor-liver-metastases
#17
Yuki Tomozawa, Younes Jahangiri, Priya Pathak, Kenneth J Kolbeck, Ryan C Schenning, John A Kaufman, Khashayar Farsad
PURPOSE: To evaluate long-term effects of yttrium-90 (90 Y) transarterial radioembolization (TARE) for unresectable hepatic metastases of neuroendocrine tumors (NETs). MATERIALS AND METHODS: Retrospective analysis of 93 patients (47 women, 46 men; mean age 59 y) who underwent resin-based 90 Y TARE was performed. Variables associated with overall survival were analyzed using univariate and multivariate models. Changes in serologic values and imaging characteristics were assessed with long-term follow-up...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29721628/impact-of-tumor-localization-on-the-outcomes-of-surgery-for-an-intrahepatic-cholangiocarcinoma
#18
Tatsuya Orimo, Toshiya Kamiyama, Tomoko Mitsuhashi, Hirofumi Kamachi, Hideki Yokoo, Kenji Wakayama, Shingo Shimada, Akihisa Nagatsu, Akinobu Taketomi
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) shows differing clinical outcomes depending on its localization. METHODS: We reviewed the surgical outcomes of 104 ICC patients who underwent liver resection at our institution. We divided ICC into hilar type (HICC) and peripheral type (PICC) depending on positive contact with the hepatic hilum on preoperative computed tomography (CT). RESULTS: The survival outcomes were significantly poorer in HICC patients...
May 2, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29721386/in-situ-delivery-of-allogeneic-natural-killer-cell-nk-combined-with-cetuximab-in-liver-metastases-of-gastrointestinal-carcinoma-a-phase-i-clinical-trial
#19
O Adotevi, Y Godet, J Galaine, Z Lakkis, I Idirene, J M Certoux, M Jary, R Loyon, C Laheurte, S Kim, A Dormoy, F Pouthier, C Barisien, F Fein, P Tiberghien, X Pivot, S Valmary-Degano, C Ferrand, P Morel, E Delabrousse, C Borg
Despite successful introduction of NK-based cellular therapy in the treatment of myeloid leukemia, the potential use of NK alloreactivity in solid malignancies is still elusive. We performed a phase I clinical trial to assess the safety and efficacy of in situ delivery of allogeneic NK cells combined with cetuximab in liver metastasis of gastrointestinal origin. The conditioning chemotherapy was administrated before the allogeneic NK cells injection via hepatic artery. Three escalating doses were tested (3...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29718861/hepatic-metastases-from-primary-extremity-leiomyosarcomas-two-case-reports
#20
Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Eiichi Konishi, Toshikazu Kubo
INTRODUCTION: Leiomyosarcoma is a highly malignant soft tissue sarcoma. Most leiomyosarcomas of the extremities metastasize initially to the lungs, with few metastasizing to the liver. Also, it is difficult to diagnose metastases to other regions of the lung during follow-up. CASE PRESENTATION: The first patient was a 51-year-old Japanese woman diagnosed with a leiomyosarcoma of the left distal femur. She underwent chemotherapy, followed by wide tumor excision and reconstruction using frozen autograft with total knee arthroplasty...
May 2018: Medicine (Baltimore)
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