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Gastric bypass metabolic syndrome

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https://www.readbyqxmd.com/read/29574099/the-role-of-laparoscopic-mini-gastric-bypass-in-management-of-metabolic-syndrome
#1
Mahmoud Abdallah El-Husseiny, Ashraf Abdel-Hameed Abdel-Moneim, Mohammed Arafat Abdel-Maksoud, Kamel Suliman Hammad
OBJECTIVE: The study was performed to evaluate the technique of laproscopic minigastric bypass for metabolic syndrome patients. STUDY DESIGN: The patients were enrolled in a combined prospective study and had a retrospectively gathered outcome analysis. PATIENT AND METHODS: The study includes thirty patients; 24 females and 6 males suffering from metabolic syndrome with a mean age of 33.15 ± 10.17 years (range, 20-59), who fulfilled the criteria for bariatric surgery with BMI >35 with associated co-morbidities, all patients underwent laparoscopic mini-gastric bypass...
March 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29573597/laparoscopic-roux-en-y-gastric-bypass-in-a-patient-with-situs-inversus-totalis-case-report-technical-tips-and-review-of-the-literature
#2
Abdelaziz Atwez, Zeid Keilani
INTRODUCTION: Laparoscopic Roux-en-Y gastric bypass (LRYGB) has proven over the years to be one of the most effective bariatric procedures. It is highly technical, and therefore is mostly performed by bariatric and metabolic surgeons. Although Situs Inversus Totalis (SIT) is a very rare congenital condition, surgeons do occasionally have to operate intra-abdominally on those patients, consequently facing some challenges related to the unusual anatomy. CASE PRESENTATION: We describe a rare case of LRYGB for chronic morbid obesity on a 43 year old patient with pre-operative diagnosis of situs inversus totalis without Kartagener's syndrome, using slight modification from the usual technique based on anatomical correlation without the need to change the surgeon's position or switching trocar placements as described in previous papers...
March 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29567059/conversion-of-standard-roux-en-y-gastric-bypass-to-distal-bypass-for-weight-loss-failure-and-metabolic-syndrome-3-year-follow-up-and-evolution-of-technique-to-reduce-nutritional-complications
#3
Saber Ghiassi, Kelvin Higa, Steven Chang, Pearl Ma, Aaron Lloyd, Keith Boone, Eric J DeMaria
BACKGROUND: Standard proximal Roux-en-Y gastric bypass (RYGB) fails to achieve long-term weight maintenance and/or control of metabolic syndrome in up to 35% of patients. OBJECTIVES: To improve the performance of the standard proximal gastric bypass by increasing the biliopancreatic limb length at the expense of the common channel. SETTINGS: Academic-affiliated private practice. METHODS: A retrospective review of all patients who underwent conversion to distal RYGB from 2010 to 2016 was performed...
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29501798/metabolic-syndrome-2-years-after-laparoscopic-gastric-bypass
#4
Lizbeth Guilbert, Cristian J Ortiz, Omar Espinosa, Elisa M Sepúlveda, Tatiana Piña, Paul Joo, Carlos Zerrweck
BACKGROUND: The latest diabetes consensus identified obesity as key component of the metabolic syndrome. The role of bariatric surgery over such syndrome has been less explored with a lack of long term studies, and especially among Mexicans. METHODS: Retrospective study including patients with metabolic syndrome submitted to laparoscopic gastric bypass at a single institution with complete data after 24 months. The objective was to analyze the improvement of the syndrome and each component...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29462566/non-alcoholic-fatty-liver-disease-and-gastric-bypass-surgery-regulate-serum-and-hepatic-levels-of-pyruvate-kinase-isoenzyme-m2
#5
Luca Meoli, Nitin K Gupta, Nima Saeidi, Courtney Panciotti, Sudha B Biddinger, Kathleen E Corey, Nicholas Stylopoulos
Treatment of non-alcoholic fatty liver disease (NAFLD) focuses on the underlying metabolic syndrome, and Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective options. In rodents and human patients, RYGB induces an increase in the gene and protein expression levels of the M2 isoenzyme of Pyruvate Kinase (PKM2) in the jejunum. Since PKM2 can be secreted in the circulation, our hypothesis was that the circulating levels of PKM2 increase after RYGB. Our data, however, revealed an unexpected finding and a potential new role of PKM2 for the natural history of metabolic syndrome and NAFLD...
February 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29325617/wilson-disease-and-related-copper-disorders
#6
Matthew T Lorincz
Copper is a required cofactor for enzymes in critical metabolic pathways. Mutations in copper metabolism genes or abnormalities in copper metabolism result in disease from copper excess or deficiency. Wilson disease (WD) is an autosomal-recessive disease caused by mutations in the ATP7B gene which encodes a copper-transporting ATPase. Over 500 different WD mutations throughout the ATP7B gene have been described, most of which are missense mutations. Mutations in both ATP7B alleles result in abnormal copper metabolism and subsequent toxic accumulation of copper...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29101558/perioperative-bleeding-and-blood-transfusion-are-major-risk-factors-for-venous-thromboembolism-following-bariatric-surgery
#7
Alexander W Nielsen, Melissa C Helm, Tammy Kindel, Rana Higgins, Kathleen Lak, Zachary M Helmen, Jon C Gould
BACKGROUND: Morbidly obese patients are at increased risk for venous thromboembolism (VTE) after bariatric surgery. Perioperative chemoprophylaxis is used routinely with bariatric surgery to decrease the risk of VTE. When bleeding occurs, routine chemoprophylaxis is often withheld due to concerns about inciting another bleeding event. We sought to evaluate the relationship between perioperative bleeding and postoperative VTE in bariatric surgery. METHODS: The American College of Surgeons-National Surgical Quality Improvement Program (NSQIP) dataset between 2012 and 2014 was queried to identify patients who underwent bariatric surgery...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29042391/korean-obesity-surgical-treatment-study-kobess-protocol-of-a-prospective-multicentre-cohort-study-on-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#8
Young Suk Park, Do Joong Park, Joo Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Seung-Wan Ryu, Sang-Moon Han, Moon-Won Yoo, Sungsoo Park, Sang-Uk Han, Yoonseok Heo
INTRODUCTION: Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. METHODS AND ANALYSIS: The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29033596/metabolic-syndrome-remission-after-roux-en-y-gastric-bypass-or-sleeve-gastrectomy
#9
Ibrahim Nassour, Jaime P Almandoz, Beverley Adams-Huet, Sachin Kukreja, Nancy Puzziferri
BACKGROUND: Bariatric surgery is known to decrease weight and the prevalence of comorbidities, but there is little evidence on the differential effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on the remission of the aggregate outcome, metabolic syndrome, 4 years after surgery. The purpose of this study was to determine the effectiveness of RYGB and SG on metabolic syndrome in veterans. METHODS: We retrospectively reviewed consecutive patients who underwent SG and RYGB at the Dallas Veterans Affairs Medical Center from 2003 to 2012...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28973478/roux-en-y-gastric-bypass-surgery-in-the-management-of-familial-partial-lipodystrophy-type-1
#10
Audrey Melvin, Claire Adams, Catherine Flanagan, Lisa Gaff, Barbara Gratton, Fiona Gribble, Geoffrey Roberts, Robert K Semple, Stephen O'Rahilly, Francesco Rubino, Anna Stears, David B Savage
Context: Familial partial lipodystrophy type 1 (FPLD1) is an extreme form of central adiposity, with peripheral lipodystrophy associated with severe manifestations of the metabolic syndrome, often poorly responsive to standard therapeutic approaches. Body mass index in FPLD1 varies but, in many cases, is below the level at which metabolic surgery is usually considered as a therapeutic option. Design: We detailed the metabolic response to gastric bypass surgery of three patients with FPLD1, refractory to medical therapy...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28963663/solo-single-incision-laparoscopic-resectional-roux-en-y-gastric-bypass-for-morbid-obesity-with-metabolic-syndrome
#11
So Hyun Kang, Yoontaek Lee, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
With the advancement of laparoscopic devices and surgical technology, the era of minimal invasive surgery has progressed to reduced-port surgery, and finally to single-incision laparoscopic surgery (SILS). Several reports show successful application of SILS to various types of bariatric surgery. Oftentimes, this requires a skilled and experienced scopist to perform the procedure. To overcome the technical difficulties of single-incision Roux-en-Y gastric bypass, a manual scope holder was used instead of an assistant scopist, greatly stabilizing the field of view...
December 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28944323/the-effects-of-bariatric-surgical-procedures-on-the-improvement-of-metabolic-syndrome-in-morbidly-obese-patients-comparison-of-laparoscopic-sleeve-gastrectomy-versus-laparoscopic-roux-en-y-gastric-bypass
#12
Mehmet Ertuğrul Kafalı, Mustafa Şahin, İlhan Ece, Fahrettin Acar, Hüseyin Yılmaz, Hüsnü Alptekin, Leyla Ateş
OBJECTIVE: The objective of this study was to evaluate patients who underwent laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy in terms of weight loss, metabolic parameters, and postoperative complications. MATERIAL AND METHODS: Data on patients who underwent laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy with a diagnosis of morbid obesity between January 2012 and June 2014 were retrospectively evaluated. Patients were compared in terms of age, sex, body mass index, duration of operation, American Society of Anesthesiologists score, perioperative complications, length of hospital stay, and long term follow-up results...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/28936585/understanding-intestinal-glucose-transporter-expression-in-obese-compared-to-non-obese-subjects
#13
Rebecca A Deal, Yueming Tang, Reid Fletcher, Alfonso Torquati, Philip Omotosho
INTRODUCTION: The impact of Roux-en-Y gastric bypass (RYGB) on weight loss and co-morbid disease resolution is well established. However, the mechanisms underlying the procedure remain incompletely understood. Intestinal remodeling involving glucose transporters (GLUTs) may play a crucial role. Rat studies have demonstrated morphological adaptation of GLUTs within adipose and intestinal cells in association with the reprogramming of glucose metabolism. There is a limited understanding of the variations in expression amongst GLUT family receptors in the human intestine...
April 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/28555086/hepatic-cd36-downregulation-parallels-steatosis-improvement-in-morbidly-obese-undergoing-bariatric-surgery
#14
E Pardina, R Ferrer, J Rossell, D Ricart-Jané, K A Méndez-Lara, J A Baena-Fustegueras, A Lecube, J Julve, J Peinado-Onsurbe
BACKGROUND: The notion that hepatic expression of genes involved in lipid metabolism is altered in obese patients is relatively new and its relationship with hepatic steatosis and cardiometabolic alterations remains unclear. OBJECTIVE: We assessed the impact of Roux-en-Y gastric bypass surgery (RYGB) on the expression profile of genes related to metabolic syndrome in liver biopsies from morbidly obese individuals using a custom-made, focused cDNA microarray, and assessed the relationship between the expression profile and hepatic steatosis regression...
September 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28534188/outcomes-of-one-anastomosis-gastric-bypass-in-472-diabetic-patients
#15
Osama Taha, Mahmoud Abdelaal, Mohamed Abozeid, Awny Askalany, Mohamed Alaa
BACKGROUND: The positive impact of Roux-en-Y gastric bypass (RYGB) on metabolic syndrome and glycemic control has been proven in obese patients. One anastomosis gastric bypass (OAGB) is a simple, effective and easy to learn procedure. OAGB provides encouraging results for the treatment of diabetes obese patients, but does it have the ability to be an alternative procedure to RYGB in the treatment of these patients? The aim of this study is to evaluate the outcomes of OAGB on diabetic obese patients at the bariatric centre of our university hospital...
November 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28465502/outcome-of-laparoscopic-gastric-bypass-in-obese-and-diabetic-patients-when-surgery-fails
#16
Silvia Palmisano, Greta Giacomel, Marta Silvestri, Michela Giuricin, Annamaria Kulla, Fabiola Giudici, Edoardo Baldini, Simone Albertario, Patrizio Capelli, Bernardo Marzano, Giovanni Fanti, Aron Zompicchiatti, Paolo Millo, Riccardo Brachet Contul, Elisa Ponte, Antonella Usai, Nicolò de Manzini
BACKGROUND: The beneficial effects of bariatric surgery on diabetes and obesity have been widely demonstrated in the literature. The aim of our study was to evaluate the rate of failure of laparoscopic gastric bypass both in terms of weight loss and metabolic remission after one follow-up year. METHODS: A longitudinal, multicenter prospective study was carried out on 771 patients affected by pathological obesity. The following parameters were recorded for each patient before surgery: anthropometric, metabolic, social, smoking habits and previous failure of other bariatric procedures...
August 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28440518/-choice-of-bariatric-and-metabolic-surgical-procedures
#17
Hui Liang, Shibo Lin, Wei Guan
Bariatric and metabolic surgery has become the clinical hot topic of the treatment of metabolic syndromes including obesity and diabetes mellitus, but how to choose the appropriate surgical procedure remains the difficult problem in clinical practice. Clinical guidelines of American Society for Metabolic and Bariatric Surgery(ASMBS)(version 2013) introduced the procedures of bariatric and metabolic surgery mainly including biliopancreatic diversion with duodenal switch(BPD-DS), laparoscopic adjustable gastric banding (LAGB), laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy(LSG)...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28411021/improvement-in-cardiovascular-risk-in-women-after-bariatric-surgery-as-measured-by-carotid-intima-media-thickness-comparison-of-sleeve-gastrectomy-versus-gastric-bypass
#18
COMPARATIVE STUDY
Jesús M Gómez-Martin, Enrique Aracil, Julio Galindo, Héctor F Escobar-Morreale, José A Balsa, José I Botella-Carretero
BACKGROUND: Bariatric surgery may diminish cardiovascular risk (CVR) and its associated mortality. However, studies that compare these effects with different techniques are scarce. OBJECTIVE: To evaluate the changes in CVR as estimated by carotid intima-media thickness (IMT) after obesity surgery in women with high CVR as defined by the presence of metabolic syndrome. SETTING: Academic hospital. METHODS: We studied 40 severely obese women, of whom 20 received laparoscopic Roux en Y gastric bypass (RYGB) and 20 received sleeve gastrectomy (SG)...
May 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28327822/impact-of-roux-en-y-gastric-bypass-surgery-rygb-on-metabolic-syndrome-components-and-on-the-use-of-associated-drugs-in-obese-patients
#19
Vilma Maria Junges, Jarbas Marinho Cavalheiro, Eliana Franzoi Fam, Vera Elizabeth Closs, João Feliz Moraes, Maria Gabriela Gottlieb
BACKGROUND: The prevalence of obesity and metabolic syndrome is increasing worldwide and both behavior modification and drug therapy have low adherence. Gastric bypass has shown effective results in both reducing weight and improving comorbidities. OBJECTIVE: To evaluate the impact of Roux-en-Y Gastric Bypass Surgery (RYGB) on both metabolic syndrome components and the use of associated drugs in obese patients. METHODS: Historical cohort of patients subjected to Roux-en-Y Gastric Bypass Surgery (RYGB) between January 2007 and March 2014 in a private clinic...
April 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28250848/tissue-specific-methylation-profile-in-obese-patients-with-type-2-diabetes-before-and-after-roux-en-y-gastric-bypass
#20
REVIEW
Priscila Sala, Raquel Susana Matos de Miranda Torrinhas, Danielle Cristina Fonseca, Graziela Rosa Ravacci, Dan Linetzky Waitzberg, Daniel Giannella-Neto
Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of genes, including genes related to glycemic control, at any stage of life. The epigenetic mechanism underlying obesity and T2D pathogenesis remains poorly understood. Conventional strategies for the treatment of obesity and its comorbidities often have poor long-term adherence, and pharmacological interventions are limited...
2017: Diabetology & Metabolic Syndrome
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