Danielle B Pier, Fabio P Nunes, Scott R Plotkin, Anat O Stemmer-Rachamimov, James C Kim, Helen A Shih, Priscilla Brastianos, Angela E Lin
Neoplasia is uncommon in Turner syndrome, although there is some evidence that brain tumors are more common in Turner syndrome patients than in the general population. We describe a woman with Turner syndrome (45,X) with a meningioma, in whom a second neoplasia, basal cell carcinomas of the scalp and nose, developed five years later in the absence of therapeutic radiation. Together with 7 cases of Turner syndrome with meningioma from a population-based survey in the United Kingdom, and 3 other isolated cases in the literature, we review this small number of patients for evidence of risk factors related to Turner syndrome, such as associated structural anomalies or prior treatment...
May 2014: European Journal of Medical Genetics