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Harsha Sugur, Arun H Shastry, Nishant Sadashiva, Dwarakanath Srinivas, Vani Santosh, Sampath Somanna
INTRODUCTION: Chordoid meningiomas (CMs) are a rare subgroup of tumors, accounting for approximately 0.5% of all meningiomas. These tumors correspond to World Health Organization (WHO) Grade II lesions and behave aggressively, with an increased likelihood of recurrence. There are only two studies that have described the genetic alterations in CMs. While a majority of meningiomas are known to have deletion at many chromosomal loci such as 22q, 18p, 14q, and 1p, which are found to be associated with initiation, progression, and malignancy of these tumors, these have not yet been studied in CMs...
January 2018: Neurology India
Mehrdad Asghari Estiar, Firouzeh Javan, Ali Zekri, Masoud Mehrazin, Parvin Mehdipour
BACKGROUND: Astrocytoma and meningioma are the most common primary brain tumors. MYCN as a member of MYC proto-oncogenes has recently appeared as an attractive therapeutic target. Functions of MYCN are critical for growth of nervous system and neural differentiation. OBJECTIVE: We examined MYCN amplification and protein expression in astrocytoma and meningioma cases. METHODS: In this study, we used real-time PCR, FISH assay and flowcytometry to analyze DNA amplification and protein expression of MYCN...
July 4, 2017: Cancer Biomarkers: Section A of Disease Markers
Abbas Agaimy, Michael Michal, Ladislav Hadravsky, Michal Michal
Follicular dendritic cell sarcoma (FDCS) is a rare low-grade neoplasm with the phenotype of FDC cells. This rare sarcoma has been well known for being mistaken for a variety of neoplasms (mainly meningioma), particularly at extranodal sites. Diagnosis of FDCS mainly relies on characteristic histologic appearance supplemented by immunohistochemistry and electron microscopy. In this study, we reviewed 15 FDCSs retrieved from our consultation files and stained them for newly reported or novel markers (PD-L1, Rb1, MDM2, and somatostatin receptor 2A [SSTR2A]) in addition to conventional FDC markers...
August 2016: Annals of Diagnostic Pathology
Recep Basaran, Serap Uslu, Berrin Gucluer, Mustafa Onoz, Nejat Isik, Mehmet Tiryaki, Cengiz Yakicier, Aydin Sav, Ilhan Elmaci
BACKGROUND: Meningiomas are one of the most common tumours to affect the central nervous system. Genetic mutations are important in meningeal tumourigenesis, progression and prognosis. In this study, we aimed to examine the effect of 1p/19q deletion on the diagnosis and prognosis of meningioma subtypes using the fluorescence in situ hybridization (FISH) method. METHODS: Twenty-four patients with meningioma were retrospectively studied. Tumour samples were obtained from 10 typical, 11 atypical and three anaplastic malignant meningiomas...
October 2016: British Journal of Neurosurgery
Annikka Weissferdt, Ximing Tang, Saul Suster, Ignacio I Wistuba, Cesar A Moran
Primary pleuropulmonary meningothelial proliferations include minute pulmonary meningothelial-like nodules (MPMN) and pleural or pulmonary meningiomas (PPM). These lesions share histologic, ultrastructural, and immunohistochemical features with meningiomas of the central nervous system (CNS). Meningiomas of the CNS exhibit a number of genetic abnormalities, most commonly loss of the neurofibromatosis (NF) 2 gene on chromosome 22. The molecular changes of pleuropulmonary meningothelial proliferations, however, have only rarely been investigated...
December 2015: American Journal of Surgical Pathology
Nishanth Sadashiva, Harsh Sugur, Dwarakanath Srinivas, Vani Santosh, Sampath Somanna
OBJECTIVE: There is significant variability in the biologic behavior of meningiomas, especially of atypical and anaplastic meningiomas, that cannot be accounted for by just histology and grade of excision. The aim of our study was to analyze deletions in regions 22q, 18p11, 1p32, and 14q32 in grade II and grade III meningiomas and their correlation with tumor grade and recurrence. MATERIALS AND METHODS: A total of 59 samples from 50 cases of grade II and grade III meningiomas were analyzed with fluorescence in situ hybridization (FISH) technique with locus specific probes...
July 2015: Neurology India
Takahiro Yamamoto, Naoki Shinojima, Tatemi Todaka, Shigeyuki Nishikawa, Shigetoshi Yano, Jun-ichi Kuratsu
BACKGROUND: Down syndrome comprises multiple malformations and is due to trisomy of chromosome 21. There is epidemiologic evidence that individuals with Down syndrome are at decreased risk for solid tumors including brain tumors. It has been suggested that some genes expressed on the extra copy of chromosome 21 act as tumor suppressor genes and contribute to protection against tumorigenesis. CASE DESCRIPTION: We report the first case to our knowledge of a patient with Down syndrome, an 8-year-old boy, with an intracranial meningioma, in which the status of chromosome 21 was examined...
September 2015: World Neurosurgery
Sawan Kumar, Aanchal Kakkar, Vaishali Suri, Anupam Kumar, Utkarsh Bhagat, Mehar Chand Sharma, Manmohan Singh, Ashish Suri, Chitra Sarkar
BACKGROUND: Meningiomas are benign central nervous system tumors; however, significant fraction recurs, irrespective of histological grade. MATERIALS AND METHODS: We performed fluorescence in-situ hybridization for 1p36 and 14q32, and immunohistochemistry for progesterone receptor (PR), p53 and MIB-1 on 84 meningiomas. RESULTS AND CONCLUSION: Sixty-four were convexity tumors (30 grade I, 21 grade II, 13 grade III) and 20 petroclival (grade I; 10 with gross total resection (GTR), 10 with subtotal resection (STR))...
July 2014: Neurology India
Florent Marguet, François Proust, Marie Crahes, Carole Basset, Géraldine Joly-Helas, Pascal Chambon, Annie Laquerrière
We report on a 51-year-old woman who presented with a cervical spinal cord tumor clinically suspected to be a metastasis. Histological examination revealed an anaplastic meningioma containing epithelial nests arranged in a gland-like pattern suggestive of adenocarcinoma. This component strongly expressed cytokeratins whereas the meningothelial component was vimentin--epithelial membrane antigen--and progesterone receptor-immunoreactive, suggesting either anaplastic meningioma with adenocarcinoma-like metaplasia, or adenocarcinoma metastasis in a meningioma, but the search for a primitive neoplasia including thoracic-abdominal-pelvic computed tomography and mammography was negative...
June 2014: Annales de Pathologie
Farah Y Abdelmontalab, Elmula I Fadl, Hm Abushama, K Kreskowski, T Liehr
Meningioma is the second most common adult central nervous system tumor. Mutations and/or deletions within the tumor suppressor gene neurofibromatosis type 2 (NF2) are associated with meningioma development and progression. We studied 29 meningioma samples by cytogenetic analysis and interphase fluorescence in situ hybridization (I-FISH) using a locus-specific probe for the NF2 gene region. We detected loss of the NF2 gene in all samples except for one. In 10 of the 29 samples, karyotypic analyses confirmed the I-FISH results and revealed additional numerical and/or structural rearrangements in nine of them...
December 2013: Balkan Journal of Medical Genetics: BJMG
Danielle B Pier, Fabio P Nunes, Scott R Plotkin, Anat O Stemmer-Rachamimov, James C Kim, Helen A Shih, Priscilla Brastianos, Angela E Lin
Neoplasia is uncommon in Turner syndrome, although there is some evidence that brain tumors are more common in Turner syndrome patients than in the general population. We describe a woman with Turner syndrome (45,X) with a meningioma, in whom a second neoplasia, basal cell carcinomas of the scalp and nose, developed five years later in the absence of therapeutic radiation. Together with 7 cases of Turner syndrome with meningioma from a population-based survey in the United Kingdom, and 3 other isolated cases in the literature, we review this small number of patients for evidence of risk factors related to Turner syndrome, such as associated structural anomalies or prior treatment...
May 2014: European Journal of Medical Genetics
Patrícia Henriques Domingues, Cristina Teodósio, Álvaro Otero, Pablo Sousa, Jesus Maria Gonçalves, Ana Belen Nieto, Maria Celeste Lopes, Catarina de Oliveira, Alberto Orfao, Maria Dolores Tabernero
AIMS: Limited information exists about the impact of cytogenetic alterations on the protein expression profiles of individual meningioma cells and their association with the clinicohistopathological characteristics of the disease. The aim of this study is to investigate the potential association between the immunophenotypic profile of single meningioma cells and the most relevant features of the tumour. METHODS: Multiparameter flow cytometry (MFC) was used to evaluate the immunophenotypic profile of tumour cells (n = 51 patients) and the Affymetrix U133A chip was applied for the analysis of the gene expression profile (n = 40) of meningioma samples, cytogenetically characterized by interphase fluorescence in situ hybridization...
April 2015: Neuropathology and Applied Neurobiology
Patrícia Henriques Domingues, Pablo Sousa, Álvaro Otero, Jesus Maria Gonçalves, Laura Ruiz, Catarina de Oliveira, Maria Celeste Lopes, Alberto Orfao, Maria Dolores Tabernero
BACKGROUND: Tumor recurrence remains the major clinical complication of meningiomas, the majority of recurrences occurring among WHO grade I/benign tumors. In the present study, we propose a new scoring system for the prognostic stratification of meningioma patients based on analysis of a large series of meningiomas followed for a median of >5 years. METHODS: Tumor cytogenetics were systematically investigated by interphase fluorescence in situ hybridization in 302 meningioma samples, and the proposed classification was further validated in an independent series of cases (n = 132) analyzed by high-density (500K) single-nucleotide polymorphism (SNP) arrays...
May 2014: Neuro-oncology
Cornelia Lerner, Ralf Ketter, Stefan Linsler, Wolfram Henn, Joachim Oertel, Steffi Urbschat
BACKGROUND: Meningiomas are mostly benign tumors which arise from the meninges. They are among the cytogenetically best-studied solid tumors, mostly displaying a normal karyotype or, as a typical primary aberration, monosomy of chromosome 22. Further secondary chromosomal aberrations, especially the deletion of chromosome 1p, are correlated with increasing biological aggressiveness up to malignancy. These data are derived from the cytogenetical characterization of 661 meningiomas, from which the genetic progression score (GPS) has been developed...
February 5, 2014: Molecular Cytogenetics
MariaDolores Tabernero, María Jara-Acevedo, Ana B Nieto, Arancha Rodríguez Caballero, Alvaro Otero, Pablo Sousa, Jesús Gonçalves, Patricia H Domingues, Alberto Orfao
BACKGROUND: Meningioma was the first solid tumor shown to contain a recurrent genetic alteration e.g. monosomy 22/del(22q), NF2 being the most relevant gene involved. Although monosomy 22/del(22q) is present in half of all meningiomas, and meningiomas frequently carry NF2 mutations, no study has been reported so far in which both alterations are simultaneously assessed and correlated with the features of the disease. METHODS: Here, we analyzed the frequency of both copy number changes involving chromosome 22 and NF2 mutations in 20 sporadic meningiomas using high-density SNP-arrays, interphase-FISH and PCR techniques...
2013: BMC Medical Genetics
Min-Kyung Kim, Chang-Ho Cho, Woo-Jung Sung, Hun-Mo Ryoo, Ho-Jun Lee, Sung-Won Youn, Kwan-Kyu Park
Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma composed of CD30-positive lymphoid cells. ALCL arising in the dura matter of the brain is even more infrequent, in which only one case has been reported worldwide so far. We report a case of a 30-year-old immunocompetent male with a dura-based mass, radiographically consistent with meningioma. However, the excised mass via a left parieto-occipital craniotomy was composed of large, pleomorphic lymphoid cells to be immunopositive for CD3, CD30, anaplastic lymphoma kinase protein-1 (ALK-1) and epithelial membrane antigen (EMA), and immunonegative for CD20, CD15 and CD68...
2013: International Journal of Clinical and Experimental Pathology
Brenda O Hamilton, Joanne S Sy, Joseph F Megyesi, Lee Cyn Ang
Background: The current methods to predict recurrence and aggressive behaviour of meningiomas rely mainly on histological grading, histological subtype, proliferative index, as well as brain invasion. In many instances, histological grade alone fails to predict recurrence in the grade I and grade II meningiomas. Deletions of 1p and 14q have previously been reported to correlate with poor prognosis in terms of either recurrence or higher histological grades. The Her2neu (ErbB2) amplification has been shown to be a useful predictor of aggressive behaviour in breast and ovarian tumours, but its significance in meningioma is so far uncertain...
May 2013: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
R Caltabiano, G M V Barbagallo, M Castaing, A Cassenti, R Senetta, P Cassoni, V Albanese, S Lanzafame
AIM: The aim of this study was to assess both the epidermal growth factor receptor (EGFR) protein expression by immunohistochemistry and the EGFR gene amplification by fluorescence in situ hybridization in meningiomas of different grade, in order to evaluate their possible role in the development of the disease. EGFR protein belongs to the family of tyrosine kinase growth factor receptors, which also includes HER2, HER3 and HER4. Elevated expression or activity of EGFR has been reported in several cancers, including brain tumours...
June 2013: Journal of Neurosurgical Sciences
Sandra Barbera, Teresa San Miguel, Rosario Gil-Benso, Lisandra Muñoz-Hidalgo, Pedro Roldan, Jose Gonzalez-Darder, Miguel Cerda-Nicolas, Concha Lopez-Gines
Meningiomas add up to 25% of intracranial tumors. Although the majority is considered histologically benign, the prediction of their potential aggressiveness is still unclear. We studied the histopathology and aberrations of chromosomes 1p, 14, and 22 by FISH (fluorescence in situ hybridization) in histologically benign meningiomas of 70 patients for the purpose of defining the prognostic value of these alterations in tumoral progression and the risk of recurrence. According to the WHO histopathological criteria, the study set comprised 53 benign, 11 atypical, and 6 anaplastic meningiomas...
July 2013: Clinical Neuropathology
Shogo Endo, Shunsuke Terasaka, Shigeru Yamaguchi, Hitoshi Ikeda, Tsutomu Kato, Hiroyuki Kobayashi, Shinya Tanaka, Kiyohiro Houkin
In the CNS, primary tumors with rhabdoid components are classified as atypical teratoid/rhabdoid tumor, rhabdoid meningioma or rhabdoid glioblastoma. The authors present a young adult patient with supratentorial rhabdoid tumor incidentally found after head trauma as a small pre-existing lesion in the parahippocampal gyrus. MRI demonstrated an area of hypointensity on T1-weighted images and hyperintensity on T2-weighted and fluid attenuated inversion recovery images. A serial MR scan revealed no change 3 months after the initial examination but drastic changes at 6 months...
April 2013: Neuropathology: Official Journal of the Japanese Society of Neuropathology
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