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https://www.readbyqxmd.com/read/29157669/the-combination-of-il-6-and-its-soluble-receptor-is-associated-with-the-response-of-rheumatoid-arthritis-patients-to-tocilizumab
#1
Cesar Diaz-Torne, Maria Dels Angels Ortiz, Patricia Moya, Maria Victoria Hernandez, Delia Reina, Ivan Castellvi, Juan Jose De Agustin, Diana de la Fuente, Hector Corominas, Raimon Sanmarti, Carlos Zamora, Elisabet Cantó, Silvia Vidal
BACKGROUND: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. We aimed to combine IL-6 and soluble IL-6R (sIL-6R) levels to identify groups of responses. METHODS: Heparinized blood and clinical data from 63 RA patients were collected before treatment and after 3 and 6 months...
November 17, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29130597/co-occurring-medical-conditions-in-adults-with-down-syndrome-a-systematic-review-toward-the-development-of-health-care-guidelines
#2
REVIEW
George T Capone, Brian Chicoine, Peter Bulova, Mary Stephens, Sarah Hart, Blythe Crissman, Andrea Videlefsky, Katherine Myers, Nancy Roizen, Anna Esbensen, Moya Peterson, Stephanie Santoro, Jason Woodward, Barry Martin, David Smith
Adults with Down syndrome (DS) represent a unique population who are in need of clinical guidelines to address their medical care. The United States Preventive Service Task Force (USPSTF) has developed criteria for prioritizing conditions of public health importance with the potential for providing screening recommendations to improve clinical care. The quality of existing evidence needed to inform clinical guidelines has not been previously reviewed. Using the National Library of Medicine (NLM) database PubMed, we first identified 18 peer reviewed articles that addressed co-occurring medical conditions in adults with DS...
November 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29115370/-febrile-syndromes-in-the-traveler-returning-from-tropical-regions-admitted-in-a-monographic-unit
#3
N Moya Notario, M Hernández-Cabrera, C Carranza-Rodríguez, E Pisos-Álamo, N Jaén-Sánchez, J L Pérez-Arellano
OBJECTIVE: The aim was to analyse those syndromes with fever in travellers who return from tropical regions evaluated at our Department of Infectology and Tropical Medicine. Clarifying these conditions intends to reach earlier diagnoses and, perhaps, to avoid the emergence and spread of imported diseases, as well as to establish appropriate preventive measures. METHODS: An observational descriptive transversal study was performed, selecting those patients who returned from tropical regions with fever, amongst all travellers evaluated in our department between 1998 and 2013...
November 8, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29075858/outcomes-for-esophageal-squamous-cell-carcinoma-treated-with-curative-intent-in-a-western-cohort-should-multimodal-therapy-be-the-gold-standard
#4
Fiachra Sheil, Claire L Donohoe, Sinéad King, Dermot O'Toole, Moya Cunningham, Sinéad Cuffe, Narayanasamy Ravi, John V Reynolds
INTRODUCTION: The standard of care for treatment of oesophageal squamous cell carcinoma (SCC) continues to evolve. Neoadjuvant chemoradiotherapy (neoCRT) provides a significant survival benefit compared to surgery alone but it is unclear whether definitive chemoradiation (dCRT) is superior. METHODS: Retrospective analysis of outcomes from patients treated in a national high-volume centre (2000-2014) where both neoCRT and dCRT are used with curative intent. Propensity score match analysis was used to match patients undergoing dCRT with those undergoing surgery ± neoCRT...
October 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29059109/metabolic-bone-diseases-and-total-hip-arthroplasty-preventing-complications
#5
Joaquin Moya-Angeler, Joseph M Lane, Jose A Rodriguez
Metabolic bone diseases are a diverse group of conditions characterized by abnormalities in calcium metabolism and/or bone cell physiology. These unbalanced processes can eventually lead to bony deformities and altered joint biomechanics, resulting in degenerative joint disease. Not infrequently, patients with metabolic bone diseases have restricting hip joint pain that ultimately necessitates hip arthroplasty. To minimize complications, the surgeon must consider the particular characteristics of these patients...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29039643/exploring-the-ph-sensitivity-of-poly-allylamine-phosphate-supramolecular-nanocarriers-for-intracellular-sirna-delivery
#6
Patrizia Andreozzi, Eleftheria Diamanti, Karen Rapp Py-Daniel, Paolin Rocio Cáceres-Vélez, Chiara Martinelli, Nikolaos Politakos, Ane Escobar, Marco Muzi-Falconi, Ricardo Azevedo, Sergio E Moya
Silencing RNA (siRNA) technologies emerge as a promising therapeutic tool for the treatment of multiple diseases. An ideal nanocarrier (NC) for siRNAs should be stable at physiological pH and release siRNAs in acidic endosomal pH, fulfilling siRNA delivery only inside cells. Here, we show a novel application of polyamine phosphate NCs (PANs) based on their capacity to load negatively charged nucleic acids and their pH stability. PANs are fabricated by complexation of phosphate anions from phosphate buffer solution (PB) with the amine groups of poly(allylamine) hydrochloride as carriers for siRNAs...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29023002/dynamics-of-huanglongbing-associated-bacterium-candidatus-liberibacter-asiaticus-in-citrus-aurantifolia-swingle-mexican-lime
#7
Jose Abel Lopez-Buenfil, Jose Abrahan Ramirez-Pool, Roberto Ruiz-Medrano, Maria Del Carmen Montes-Horcasitas, Claudio Chavarin-Palacio, Jesus Moya-Hinojosa, Francisco Javier Trujillo-Arriaga, Rosalia Lira Carmona, Beatriz Xoconostle-Cazares
BACKGROUND: The bacterial disease citrus huanglongbing (HLB), associated with "Candidatus Liberibacter asiaticus" (C.Las) has severely impacted the citrus industry, causing a significant reduction in production and fruit quality. In the present study, it was monitored the C.Las population dynamics in symptomatic, HLB-positive Mexican lime trees (Citrus aurantifolia Swingle) in a tropical, citrus-producing area of Mexico. The objective of this study was to identify the dynamics of the population of huanglongbing-associated bacterium Candidatus Liberibacter asiaticus and its insect vector in Citrus aurantifolia Swingle (Mexican lime)...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29016882/intra-atrial-re-entrant-tachycardia-in-patients-with-congenital-heart-disease-factors-associated-with-disease-severity
#8
Ivo Roca-Luque, Nuria Rivas Gándara, Laura Dos Subirà, Jaume Francisco Pascual, Jordi Pérez-Rodon, Antònia Pijuan Domenech, Ma Teresa Subirana, Berta Miranda, Alba Santos Ortega, Jaume Casaldàliga Ferrer, David García-Dorado García, Angel Moya Mitjans
Aim: Intra-atrial re-entrant tachycardia (IART) is a common complication in patients with congenital heart disease (CHD) and is related to increased morbidity and mortality. Few reports have been published about factors associated to IART severity. The aim of this study is to analyse factors associated to severe clinical presentation of IART. Methods and Results: Observational study of all consecutive CHD patients who underwent a first IART ablation from January 2009 to December 2015 (94 patients, 39...
July 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016802/intra-atrial-re-entrant-tachycardia-in-congenital-heart-disease-types-and-relation-of-isthmus-to-atrial-voltage
#9
Ivo Roca-Luque, Nuria Rivas Gándara, Laura Dos Subirà, Jaume Francisco Pascual, Antònia Pijuan Domenech, Jordi Pérez-Rodon, M Teresa Subirana, Alba Santos Ortega, Berta Miranda, Ferran Rosés-Noguer, Ignacio Ferreira-Gonzalez, Jaume Casaldàliga Ferrer, David García-Dorado García, Angel Moya Mitjans
Background: Intra-atrial re-entrant tachycardia (IART) is a frequent and severe complication in patients with congenital heart disease (CHD). Cavotricuspid isthmus (CTI)-related IART is the most frequent mechanism. However, due to fibrosis and surgical scars, non-CTI-related IART is also frequent. Objective: The main objective of this study was to describe the types of IART and circuit locations and to define a cut-off value for unhealthy tissue in the atria. Methods and results: This observational study included all consecutive patients with CHD who underwent a first ablation procedure for IART from January 2009 to December 2015 (94 patients, 39...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28985450/patterns-of-periodontal-disease-progression-based-on-linear-mixed-models-of-clinical-attachment-loss
#10
Ricardo Teles, Kevin Moss, John S Preisser, Robert Genco, William V Giannobile, Patricia Corby, Nathalia Garcia, Heather Jared, Gay Torresyap, Elida Salazar, Julie Moya, Cynthia Howard, Robert Schifferle, Karen L Falkner, Jane Gillespie, Debra Dixon, MaryAnn Cugini
AIM: The goal of the present longitudinal cohort study was to examine patterns of periodontal disease progression at progressing sites and subjects defined based on linear mixed models (LMM) of clinical attachment loss (CAL). MATERIALS AND METHODS: A total of 113 periodontally healthy and 302 periodontitis subjects had their CAL calculated bimonthly for 12 months. LMMs were fitted for each site and the predicted CAL levels used to categorize their progression state...
October 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28978344/the-expect-examining-exercise-prostate-cancer-and-circulating-tumour-cells-trial-study-protocol-for-a-randomised-controlled-trial
#11
Gráinne Sheill, Lauren Brady, Emer Guinan, Brian Hayes, Orla Casey, John Greene, Tatjana Vlajnic, Fidelma Cahill, Mieke Van Hemelrijck, Nicola Peat, Sarah Rudman, Juliette Hussey, Moya Cunningham, Liam Grogan, Thomas Lynch, Rustom P Manecksha, John McCaffrey, Lorelei Mucci, Orla Sheils, John O'Leary, Dearbhaile M O'Donnell, Ray McDermott, Stephen Finn
BACKGROUND: Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population...
October 4, 2017: Trials
https://www.readbyqxmd.com/read/28973390/association-of-krouse-classification-for-sinonasal-inverted-papilloma-with-recurrence-a-systematic-review-and-meta-analysis
#12
Quentin Lisan, Antoine Moya-Plana, Pierre Bonfils
Importance: The risk factors for the recurrence of sinonasal inverted papilloma are still unclear. Objective: To investigate the potential association between the Krouse classification and the recurrence rates of sinonasal inverted papilloma. Data Sources: The EMBASE and MEDLINE databases were searched for the period January 1, 1964, through September 30, 2016, using the following search strategy: (paranasal sinuses [Medical Subject Headings (MeSH) terms] OR sinonasal [all fields]) AND (inverted papilloma [MeSH terms] OR (inverted [all fields] AND papilloma [all fields])...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28966146/understanding-gene-functions-and-disease-mechanisms-phenotyping-pipelines-in-the-german-mouse-clinic
#13
REVIEW
Helmut Fuchs, Juan Antonio Aguilar-Pimentel, Oana V Amarie, Lore Becker, Julia Calzada-Wack, Yi-Li Cho, Lillian Garrett, Sabine M Hölter, Martin Irmler, Martin Kistler, Markus Kraiger, Philipp Mayer-Kuckuk, Kristin Moreth, Birgit Rathkolb, Jan Rozman, Patricia da Silva Buttkus, Irina Treise, Annemarie Zimprich, Kristine Gampe, Christine Hutterer, Claudia Stöger, Stefanie Leuchtenberger, Holger Maier, Manuel Miller, Angelika Scheideler, Moya Wu, Johannes Beckers, Raffi Bekeredjian, Markus Brielmeier, Dirk H Busch, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Tobias Stöger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Valérie Gailus-Durner, Martin Hrabě de Angelis
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas...
September 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28965876/microbiota-related-changes-in-bile-acid-tryptophan-metabolism-are-associated-with-gastrointestinal-dysfunction-in-a-mouse-model-of-autism
#14
Anna V Golubeva, Susan A Joyce, Gerard Moloney, Aurelijus Burokas, Eoin Sherwin, Silvia Arboleya, Ian Flynn, Dmitry Khochanskiy, Angela Moya-Pérez, Veronica Peterson, Kieran Rea, Kiera Murphy, Olga Makarova, Sergey Buravkov, Niall P Hyland, Catherine Stanton, Gerard Clarke, Cormac G M Gahan, Timothy G Dinan, John F Cryan
Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There is growing awareness that ASD is highly comorbid with gastrointestinal distress and altered intestinal microbiome, and that host-microbiome interactions may contribute to the disease symptoms. However, the paucity of knowledge on gut-brain axis signaling in autism constitutes an obstacle to the development of precision microbiota-based therapeutics in ASD. To this end, we explored the interactions between intestinal microbiota, gut physiology and social behavior in a BTBR T(+)Itpr3(tf)/J mouse model of ASD...
October 2017: EBioMedicine
https://www.readbyqxmd.com/read/28943635/ng2-antigen-is-involved-in-leukemia-invasiveness-and-central-nervous-system-infiltration-in-mll-rearranged-infant-b-all
#15
C Prieto, B López-Millán, H Roca-Ho, R W Stam, D Romero-Moya, F J Rodríguez-Baena, A Sanjuan-Pla, V Ayllón, M Ramírez, M Bardini, P De Lorenzo, M G Valsecchi, M Stanulla, M Iglesias, P Ballerini, Á M Carcaboso, J Mora, F Locatelli, A Bertaina, L Padilla, J Carlos Rodríguez-Manzaneque, C Bueno, P Menéndez
Mixed-lineage leukemia (MLL)-rearranged (MLLr) infant B-cell acute lymphoblastic leukemia (iMLLr-B-ALL) has a dismal prognosis and is associated with a pro-B/mixed phenotype, therapy refractoriness and frequent central nervous system (CNS) disease/relapse. Neuron-glial antigen 2 (NG2) is specifically expressed in MLLr leukemias and is used in leukemia immunophenotyping because of its predictive value for MLLr acute leukemias. NG2 is involved in melanoma metastasis and brain development; however, its role in MLL-mediated leukemogenesis remains elusive...
September 25, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28925802/higher-prevalence-of-spontaneous-cerebral-vasculopathy-and-cerebral-infarcts-in-a-mouse-model-of-sickle-cell-disease
#16
Hyacinth I Hyacinth, Courtney L Sugihara, Thomas L Spencer, David R Archer, Andy Y Shih
Stroke is a dramatic complication of sickle cell disease (SCD), which is associated with cerebral vasculopathies including moya moya, intravascular thrombi, cerebral hyperemia, and increased vessel tortuosity. The spontaneous occurrence of these pathologies in the sickle cell mouse model has not been described. Here, we studied Townes humanized sickle cell and age-matched control mice that were 13 months old. We used in vivo two-photon microscopy to assess blood flow dynamics, vascular topology, and evidence of cerebral vasculopathy...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28919898/chitosan-increases-tomato-root-colonization-by-pochonia-chlamydosporia-and-their-combination-reduces-root-knot-nematode-damage
#17
Nuria Escudero, Federico Lopez-Moya, Zahra Ghahremani, Ernesto A Zavala-Gonzalez, Aurora Alaguero-Cordovilla, Caridad Ros-Ibañez, Alfredo Lacasa, Francisco J Sorribas, Luis V Lopez-Llorca
The use of biological control agents could be a non-chemical alternative for management of Meloidogyne spp. [root-knot nematodes (RKN)], the most damaging plant-parasitic nematodes for horticultural crops worldwide. Pochonia chlamydosporia is a fungal parasite of RKN eggs that can colonize endophytically roots of several cultivated plant species, but in field applications the fungus shows a low persistence and efficiency in RKN management. The combined use of P. chlamydosporia with an enhancer could help its ability to develop in soil and colonize roots, thereby increasing its efficiency against nematodes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28898344/-lung-epithelioid-hemangioendothelioma-report-of-one-case
#18
Manuel Quiroz, Álvaro Undurraga, Rafael Moya, Cristina Fernández, Katiuska Bezares, Virginia Linacre
Epithelioid hemangioendothelioma is a multifocal tumor that rarely metastasizes. It is difficult to diagnose, most often it is an incidental finding in young asymptomatic women. The radiologic pattern is heterogeneous. Histologic confirmation of Weibel-Palade bodies or immunohistochemistry based on specific tumor markers such as factor VIII and CD34 are the most important finding to confirm the diagnosis. We report a 21 years old woman Presenting with cough and dyspnea. A chest X ray was suggestive of tuberculosis...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28861526/metabolic-network-analysis-and-metatranscriptomics-reveal-auxotrophies-and-nutrient-sources-of-the-cosmopolitan-freshwater-microbial-lineage-aci
#19
Joshua J Hamilton, Sarahi L Garcia, Brittany S Brown, Ben O Oyserman, Francisco Moya-Flores, Stefan Bertilsson, Rex R Malmstrom, Katrina T Forest, Katherine D McMahon
An explosion in the number of available genome sequences obtained through metagenomics and single-cell genomics has enabled a new view of the diversity of microbial life, yet we know surprisingly little about how microbes interact with each other or their environment. In fact, the majority of microbial species remain uncultivated, while our perception of their ecological niches is based on reconstruction of their metabolic potential. In this work, we demonstrate how the "seed set framework," which computes the set of compounds that an organism must acquire from its environment (E...
July 2017: MSystems
https://www.readbyqxmd.com/read/28790179/high-prevalence-of-ccdc103-p-his154pro-mutation-causing-primary-ciliary-dyskinesia-disrupts-protein-oligomerisation-and-is-associated-with-normal-diagnostic-investigations
#20
Amelia Shoemark, Eduardo Moya, Robert A Hirst, Mitali P Patel, Evelyn A Robson, Jane Hayward, Juliet Scully, Mahmoud R Fassad, William Lamb, Miriam Schmidts, Mellisa Dixon, Ramila S Patel-King, Andrew V Rogers, Andrew Rutman, Claire L Jackson, Patricia Goggin, Bruna Rubbo, Sarah Ollosson, Siobhán Carr, Woolf Walker, Beryl Adler, Michael R Loebinger, Robert Wilson, Andrew Bush, Hywel Williams, Christopher Boustred, Lucy Jenkins, Eamonn Sheridan, Eddie M K Chung, Christopher M Watson, Thomas Cullup, Jane S Lucas, Priti Kenia, Christopher O'Callaghan, Stephen M King, Claire Hogg, Hannah M Mitchison
RATIONALE: Primary ciliary dyskinesia is a genetically heterogeneous inherited condition characterised by progressive lung disease arising from abnormal cilia function. Approximately half of patients have situs inversus. The estimated prevalence of primary ciliary dyskinesia in the UK South Asian population is 1:2265. Early, accurate diagnosis is key to implementing appropriate management but clinical diagnostic tests can be equivocal. OBJECTIVES: To determine the importance of genetic screening for primary ciliary dyskinesia in a UK South Asian population with a typical clinical phenotype, where standard testing is inconclusive...
August 8, 2017: Thorax
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