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https://www.readbyqxmd.com/read/29768354/feasibility-and-effectiveness-of-electrochemical-dermal-conductance-measurement-for-the-screening-of-diabetic-neuropathy-in-primary-care-decoding-study-dermal-electrochemical-conductance-in-diabetic-neuropathy-rationale-and-design
#1
Juan J Cabré, Teresa Mur, Bernardo Costa, Francisco Barrio, Charo López-Moya, Ramon Sagarra, Montserrat García-Barco, Jesús Vizcaíno, Immaculada Bonaventura, Nicolau Ortiz, Gemma Flores-Mateo
Diabetes mellitus is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy is a frequent complication of diabetes and may have great clinical transcendence due to pain and possible ulceration of the lower extremities. It is also a relevant cause of morbidity and mortality in patients with diabetes. Although the cause of polyneuropathy in patients with diabetes is only partially known, it has been associated with chronic hyperglycemia suggesting the possible etiopathogenic implication of advanced glycosylation end products...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29724098/simulations-and-experiments-delineate-amyloid-fibrilization-by-peptides-derived-from-glaucoma-associated-myocilin
#2
Yiming Wang, Yuan Gao, Shannon E Hill, Dustin J E Huard, Moya O Tomlin, Raquel L Lieberman, Anant K Paravastu, Carol K Hall
Mutant myocilin aggregation is associated with inherited open angle glaucoma, a prevalent optic neuropathy leading to blindness. Comprehension of mutant myocilin aggregation is of fundamental importance to glaucoma pathogenesis and ties glaucoma to amyloid diseases such as Alzheimer's. Here we probe the aggregation properties of peptides derived from the myocilin olfactomedin domain. Peptides P1 (residues 326-337) and P3 (residues 426-442) were identified previously to form amyloid. Coarse-grained discontinuous molecular dynamics simulations using the PRIME20 force field (DMD/PRIME20) predict that P1 and P3 are aggregation-prone; P1 consistently forms fibrillar aggregates with parallel in-register β-sheets whereas P3 forms β-sheet-containing aggregates without distinct order...
May 3, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29723238/interruption-of-onchocerciasis-transmission-in-bioko-island-accelerating-the-movement-from-control-to-elimination-in-equatorial-guinea
#3
Zaida Herrador, Belén Garcia, Policarpo Ncogo, Maria Jesus Perteguer, Jose Miguel Rubio, Eva Rivas, Marta Cimas, Guillermo Ordoñez, Silvia de Pablos, Ana Hernández-González, Rufino Nguema, Laura Moya, María Romay-Barja, Teresa Garate, Kira Barbre, Agustín Benito
BACKGROUND: Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study was conducted from September 2016 to January 2017...
May 3, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29706002/-subclinical-enthesopathy-of-at-least-one-extensor-digitorum-tendon-is-highly-prevalent-and-associated-with-clinical-and-ultrasound-alterations-of-the-adjacent-finger-nails-in-patients-with-psoriatic-disease
#4
P Moya Alvarado, E Roé Crespo, F Z Muñoz-Garza, A López-Ferrer, A Laiz Alonso, E Vilarrassa Rull, J Casademont, L Puig Sanz
BACKGROUND: Nail psoriasis disease is associated with an increased probability of psoriatic arthritis and its clinical signs may have different correlates with the pathogenesis of adjacent bone destruction and have different prognostic value. Recent publications about psoriasis and nail psoriatic disease describe different ultrasonographic findings but the relationship between these ungueal alterations measured by ultrasonography and the presence of enthesopathy of the extensor digitorum has yet to be discovered...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29691984/identification-of-novel-cyp4v2-genotypes-associated-with-bietti-crystalline-dystrophy-and-atypical-anterior-segment-phenotypes-in-spanish-patients
#5
Gerardo Pedro García-García, Magdalena Martínez-Rubio, Medina-Azahara Moya-Moya, Juan José Pérez-Santonja, Julio Escribano
PURPOSE: To identify the spectrum of disease-causing CYP4V2 variants in Spanish patients with clinically diagnosed Bietti crystalline dystrophy (BCD) over an 8-year period and to analyse the phenotype-genotype correlation of the identified variants. METHODS: Four unrelated Spanish probands with a clinical diagnosis of BCD were recruited. Ophthalmological examination included visual acuity (VA), slit lamp examination, in vivo corneal confocal microscopy, funduscopy and fluoresceinic angiography...
April 25, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29602766/predictors-of-acute-failure-ablation-of-intra-atrial-re-entrant-tachycardia-in-patients-with-congenital-heart-disease-cardiac-disease-atypical-flutter-and-previous-atrial-fibrillation
#6
Ivo Roca-Luque, Nuria Rivas-Gándara, Laura Dos-Subirà, Jaume Francisco-Pascual, Antònia Pijuan-Domenech, Jordi Pérez-Rodon, Alba Santos-Ortega, Ferran Roses-Noguer, Ignacio Ferreira-Gonzalez, David García-Dorado García, Angel Moya Mitjans
BACKGROUND: Intra-atrial re-entrant tachycardia (IART) in patients with congenital heart disease (CHD) increases morbidity and mortality. Radiofrequency catheter ablation has evolved as the first-line treatment. The aim of this study was to analyze the acute success and to identify predictors of failed IART radiofrequency catheter ablation in CHD. METHODS AND RESULTS: The observational study included all consecutive patients with CHD who underwent a first ablation procedure for IART at a single center from January 2009 to December 2015 (94 patients, 39...
March 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29588406/robust-phagocyte-recruitment-controls-the-opportunistic-fungal-pathogen-mucor-circinelloides-in-innate-granulomas-in-vivo
#7
Sarah Inglesfield, Aleksandra Jasiulewicz, Matthew Hopwood, James Tyrrell, George Youlden, Maria Mazon-Moya, Owain R Millington, Serge Mostowy, Sara Jabbari, Kerstin Voelz
Mucormycosis is an emerging fungal infection with extremely high mortality rates in patients with defects in their innate immune response, specifically in functions mediated through phagocytes. However, we currently have a limited understanding of the molecular and cellular interactions between these innate immune effectors and mucormycete spores during the early immune response. Here, the early events of innate immune recruitment in response to infection by Mucor circinelloides spores are modeled by a combined in silico modeling approach and real-time in vivo microscopy...
March 27, 2018: MBio
https://www.readbyqxmd.com/read/29575799/sentinel-lymph-node-biopsy-in-33-non-melanoma-skin-cancers-of-the-head-and-neck-a-twelve-year-experience-with-long-term-follow-up
#8
LETTER
J P Foy, F Kolb, E Routier, A Cavalcanti, J Lumbroso, G Tomasic, C Mateus, S Temam, C Robert, A Moya-Plana
No abstract text is available yet for this article.
March 24, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29575713/functional-transcriptomic-annotation-and-protein-protein-interaction-analysis-identify-ezh2-and-ube2c-as-key-upregulated-proteins-in-ovarian-cancer
#9
Sandra Martínez-Canales, Miguel López de Rodas, Miriam Nuncia-Cantarero, Raquel Páez, Eitan Amir, Balázs Győrffy, Atanasio Pandiella, Eva María Galán-Moya, Alberto Ocaña
Although early stage ovarian cancer is in most cases a curable disease, some patients relapse even with appropriate adjuvant treatment. Therefore, the identification of patient and tumor characteristics to better stratify risk and guide rational drug development is desirable. Using transcriptomic functional annotation followed by protein-protein interacting (PPI) network analyses, we identified functions that were upregulated and associated with detrimental outcome in patients with early stage ovarian cancer...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29555891/teaching-neuroimages-adult-onset-vanishing-white-matter-disease
#10
Rocío-Nur Villar-Quiles, Celia Delgado-Suárez, Manuela Jorquera-Moya, Javier Arpa-Gutiérrez, Gloria Ortega-Suero
No abstract text is available yet for this article.
March 20, 2018: Neurology
https://www.readbyqxmd.com/read/29552728/sentinel-lymph-node-biopsy-in-cutaneous-head-and-neck-melanoma
#11
D Evrard, E Routier, C Mateus, G Tomasic, J Lombroso, F Kolb, C Robert, A Moya-Plana
PURPOSE: Sentinel lymph node biopsy (SLNB) is now a standard of care for cutaneous melanoma, but it is still controversial for cutaneous head and neck melanoma (CHNM). This study aims to confirm the feasibility, accuracy and low morbidity of SLNB in CHNM and evaluate its prognostic value. METHODS: A monocentric and retrospective study on patients with CHNM treated in our tertiary care center (Gustave Roussy) between January 2008 and December 2012 was performed. The feasibility, morbidity and prognostic value of this technique were analysed...
May 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29546917/-the-role-of-pulmonary-hypertension-on-bronchopulmonary-dysplasia
#12
D Valenzuela, F Moya, M Luco, J L Tapia
50 years ago, Northway described Broncopulmonary Dysplasia (BPD) in preterm infants exposed to mechanical ventilation. Since then, their survival has increased, nevertheless a "new BPD" has appeared and its incidence has not diminished. One of the characteristics of this pathology is the the abnormal vascular remodeling, which in its most severe expression is known as Pulmonary Hyper tension (PH); with an incidence of 17% in patients with BPD, which is proportional to the severity of the disease (33% in severe BPD), and as mortality factor (up to 48% 2-year mortality in PH-BPD)...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29509840/msr1-repeats-modulate-gene-expression-and-affect-risk-of-breast-and-prostate-cancer
#13
A M Rose, A Krishan, C F Chakarova, L Moya, S Chambers, M Hollands, J C Illingworth, S M G Williams, H E James, A Z Shah, C N A Palmer, A Chakravarti, J N Berg, J Batra, S S Bhattacharya
Background: MSR1 repeats are a 36-38bp minisatellite element that have recently been implicated in the regulation of gene expression, through copy number variation (CNV). Patients and methods: Bioinformatic and experimental methods were used to assess the distribution of MSR1 across the genome, evaluate the regulatory potential of such elements and explore the role of MSR1 elements in cancer, particularly non-familial breast cancer and prostate cancer. Results: MSR1s are predominately located at chromosome 19 and are functionally enriched in regulatory regions of the genome, particularly regions implicated in short-range regulatory activities (H3K27ac, H3K4me1, and H3K4me3)...
March 2, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29475609/moya-moya-syndrome-after-cranial-radiation-for-optic-glioma-with-nf1-case-report-and-literature-review-of-syndromic-cases
#14
P Brandicourt, L Bonnet, Y Béjot, C Drouet, T Moulin, L Thines
INTRODUCTION: Moya-Moya angiopathy is a neurovascular disease that predisposes to ischemic or hemorrhagic strokes. It is generated by a steno-occlusion of the terminal portion of the internal carotid arteries, which induces the development of abnormal neovessels in the deep regions of the brain. Some pathologies such as sickle cell disease, Down syndrome or Graves' disease may be associated with Moya-Moya angiopathy. These syndromic forms harbor several differences compared with idiopathic Moya-Moya disease...
March 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29434314/elevated-circulating-levels-of-succinate-in-human-obesity-are-linked-to-specific-gut-microbiota
#15
Carolina Serena, Victoria Ceperuelo-Mallafré, Noelia Keiran, Maria Isabel Queipo-Ortuño, Rosa Bernal, Ricardo Gomez-Huelgas, Mireia Urpi-Sarda, Mónica Sabater, Vicente Pérez-Brocal, Cristina Andrés-Lacueva, Andres Moya, Francisco J Tinahones, Jose Manuel Fernández-Real, Joan Vendrell, Sonia Fernández-Veledo
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29412263/zika-and-aedes-aegypti-new-and-old-challenges
#16
Flávia Thedim Costa Bueno, Mónica García, José Moya, Ilana Löwy, Jaime L Benchimol, Roberta C Cerqueira, Marcos Cueto
Infection with the zika virus had a great impact not only on pregnant women and newborns, but also on public health, on popular ideas about Aedes aegypti and with respect to women's social rights. The objective of this paper is to identify this impact and the historical, social and health changes of the disease and the legacy of the zika virus. Interventions by researchers from different specialties foster conditions for more comprehensive investigations into future epidemic threats in Brazil and Latin America...
October 2017: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29404699/paraoxonases-metabolic-role-and-pharmacological-projection
#17
REVIEW
Carlos Moya, Salvador Máñez
Atherosclerosis is one of the leading causes of death in Western countries, with high-density lipoproteins (HDL) playing an important protective role due to their ability to inhibit oxidation of low-density lipoproteins (LDL), thus relieving vascular subendothelial damage. One of the proteins constituting HDL particles is paraoxonase-1 (PON1), an enzyme able to hydrolyze aryl esters, lactones, and organophosphates. Other closely related paraoxonases are designated as PON2, which is a protein localized inside many different kinds of cells, and PON3, not only present in HDL but also in mitochondria and endoplasmic reticulum, as well...
April 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29402077/trifunctional-high-throughput-screen-identifies-promising-scaffold-to-inhibit-grp94-and-treat-myocilin-associated-glaucoma
#18
Dustin J E Huard, Vincent M Crowley, Yuhong Du, Ricardo A Cordova, Zheying Sun, Moya O Tomlin, Chad A Dickey, John Koren, Laura Blair, Haian Fu, Brian S J Blagg, Raquel L Lieberman
Gain-of-function mutations within the olfactomedin (OLF) domain of myocilin result in its toxic intracellular accumulation and hasten the onset of open-angle glaucoma. The absence of myocilin does not cause disease; therefore, strategies aimed at eliminating myocilin could lead to a successful glaucoma treatment. The endoplasmic reticulum Hsp90 paralog Grp94 accelerates OLF aggregation. Knockdown or pharmacological inhibition of Grp94 in cells facilitates clearance of mutant myocilin via a non-proteasomal pathway...
April 20, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29383034/combination-of-immunotherapy-with-targeted-therapies-in-advanced-non-small-cell-lung-cancer-nsclc
#19
REVIEW
Irene Moya-Horno, Santiago Viteri, Niki Karachaliou, Rafael Rosell
Treatment for advanced non-small cell lung cancer (NSCLC) has been significantly improved in recent years with the incorporation of drugs targeting antiangiogenesis and more specifically genomic alterations such as the EGFR mutations and ALK translocations. However, most patients invariably progress and die. The emergence of immune checkpoint inhibitors targeting the pathways involved in tumor-induced immunosuppression have redefined the management of the disease, achieving significant long-lasting responses with manageable safety profiles, regardless of histology...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29370428/the-effect-of-high-volume-online-haemodiafiltration-on-nutritional-status-and-body-composition-the-protein-stores-preservation-peset-study
#20
Pablo Molina, Belén Vizcaíno, Mariola D Molina, Sandra Beltrán, Mercedes González-Moya, Antonio Mora, Cristina Castro-Alonso, Julia Kanter, Ana I Ávila, José L Górriz, Nuria Estañ, Luis M Pallardó, Denis Fouque, Juan J Carrero
Background: Compared with conventional haemodialysis (HD), online haemodiafiltration (OL-HDF) achieves a more efficient removal of uraemic toxins and reduces inflammation, which could favourably affect nutritional status. We evaluate the effect of OL-HDF on body composition and nutritional status in prevalent high-flux HD (HF-HD) patients. Methods: In all, 33 adults with chronic kidney disease (CKD) Stage 5 undergoing maintenance HF-HD were assigned to post-dilution OL-HDF (n = 17) or to remain on HF-HD (n = 16, control group) for 12 months...
January 22, 2018: Nephrology, Dialysis, Transplantation
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