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https://www.readbyqxmd.com/read/28061448/targeting-basal-like-breast-tumors-with-bromodomain-and-extraterminal-domain-bet-and-polo-like-kinase-inhibitors
#1
Cristina Nieto-Jiménez, Ana Alcaraz-Sanabria, Javier Pérez-Peña, Verónica Corrales-Sánchez, Gemma Serrano-Heras, Eva M Galán-Moya, Leticia Serrano-Oviedo, Juan Carlos Montero, Miguel Burgos, Juan Llopis, Atanasio Pandiella, Alberto Ocaña
Metastatic triple negative breast cancer (TNBC) is an incurable disease with limited therapeutic options, and no targeted therapies available. Triple negative tumors and the basal-like genomic subtype, are both characterized by a high proliferation rate and an increase in cell division. In this context, protein kinases involved in the mitotic formation have a relevant role in this tumor subtype. Recently, Bromodomain and extraterminal domain (BET) inhibitors have shown to be active in this disease by modulating the expression of several transcription factors...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28040232/how-well-do-children-with-cystic-fibrosis-sleep-an-actigraphic-and-questionnaire-based-study
#2
Moya Vandeleur, Lisa M Walter, David S Armstrong, Philip Robinson, Gillian M Nixon, Rosemary S C Horne
OBJECTIVE: To measure sleep patterns and quality, objectively and subjectively, in clinically stable children with cystic fibrosis (CF) and healthy control children, and to examine the relationship between sleep quality and disease severity. STUDY DESIGN: Clinically stable children with CF and healthy control children (7-18 years of age) were recruited. Sleep patterns and quality were measured at home with actigraphy (14 days). Overnight peripheral capillary oxygen saturation was measured via the use of pulse oximetry...
December 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27932126/pretransplant-cd28-biomarker-levels-of-expression-and-quantification-of-molecules-per-cell-in-peripheral-cd4-t-cells-predicts-acute-rejection-episodes-in-liver-and-kidney-recipients
#3
F Boix, J M Bolarín, J Eguía, G Gonzalez-Martinez, J De La Peña, J A Galian, A M Hernández-Martínez, M R Moya-Quiles, I Legaz, J A Campillo, P Ramirez, F Sanchez-Bueno, A M García-Alonso, J A Pons, A Minguela, S Llorente, M Muro
BACKGROUND: Acute rejection (AR) remains a significant cause of graft loss. Better approaches to predict AR are being investigated. Surface CD28 protein is essential for T-cell proliferation and survival as well as cytokine production. PATIENTS AND METHODS: Pretransplant CD4(+)CD28(+) peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry. RESULTS: Pretransplant CD4(+)CD28(+) T cells in LRs were significantly lower in rejectors than nonrejectors (P = ...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27894725/occurrence-of-antiparasitic-pesticides-in-sediments-near-salmon-farms-in-the-northern-chilean-patagonia
#4
Felipe Tucca, Heriberto Moya, Karla Pozo, Francesca Borghini, Silvano Focardi, Ricardo Barra
Growth of the aquaculture industry has triggered the need for research into the potential environmental impact of chemicals used by salmon farms to control diseases. In this study, the antiparasitic pesticides emamectin benzoate (EB), diflubenzuron (DI), teflubenzuron (TE), and cypermethrin (CP) were measured in sediments near salmon cages in southern Chile. Concentrations for EB were between 2.2 and 14.6ngg(-1), while the benzoylphenyl ureas DI and TE were detected in the ranges of 0.1 to 1.2ngg(-1) and 0...
November 25, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27855309/evidence-of-an-epistatic-effect-between-dysbindin-1-and-neuritin-1-genes-on-the-risk-for-schizophrenia-spectrum-disorders
#5
C Prats, B Arias, J Moya-Higueras, E Pomarol-Clotet, M Parellada, A González-Pinto, V Peralta, M I Ibáñez, M Martín, L Fañanás, M Fatjó-Vilas
BACKGROUND: The interest in studying gene-gene interactions is increasing for psychiatric diseases such as schizophrenia-spectrum disorders (SSD), where multiple genes are involved. Dysbindin-1 (DTNBP1) and Neuritin-1 (NRN1) genes have been previously associated with SSD and both are involved in synaptic plasticity. We aimed to study whether these genes show an epistatic effect on the risk for SSD. METHODS: The sample comprised 388 SSD patients and 397 healthy subjects...
November 14, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27797112/killer-immunoglobulin-like-receptor-repertoire-analysis-in-a-caucasian-spanish-cohort-with-inflammatory-bowel-disease
#6
Ruth López-Hernández, Jose A Campillo, Isabel Legaz, Mariano Valdés, Hortensia Salama, Francisco Boix, A M Hernández-Martínez, Jorge Eguia, G González-Martínez, Maria R Moya-Quiles, Alfredo Minguela, Ana García-Alonso, Fernando Carballo, Manuel Muro
Immunological molecules are implicated in inflammatory disorders, including inflammatory bowel disease (IBD; Crohn disease [CD] and ulcerative colitis [UC]). Killer cell immunoglobulin-like receptors (KIRs) are also genetically variable proteins involved in immune function. They are expressed by NK cells and certain T lymphocytes, regulate specificity and function by interaction with HLA Class I molecules, may be either inhibitory or activating and are polymorphic both in terms of alleles and haplotype gene content...
November 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27757389/the-monoclonal-antitoxin-antibodies-actoxumab-bezlotoxumab-treatment-facilitates-normalization-of-the-gut-microbiota-of-mice-with-clostridium-difficile-infection
#7
Mária Džunková, Giuseppe D'Auria, Hua Xu, Jun Huang, Yinghua Duan, Andrés Moya, Ciarán P Kelly, Xinhua Chen
Antibiotics have significant and long-lasting impacts on the intestinal microbiota and consequently reduce colonization resistance against Clostridium difficile infection (CDI). Standard therapy using antibiotics is associated with a high rate of disease recurrence, highlighting the need for novel treatment strategies that target toxins, the major virulence factors, rather than the organism itself. Human monoclonal antibodies MK-3415A (actoxumab-bezlotoxumab) to C. difficile toxin A and toxin B, as an emerging non-antibiotic approach, significantly reduced the recurrence of CDI in animal models and human clinical trials...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27736752/deciphering-the-resistome-of-the-widespread-pseudomonas-aeruginosa-sequence-type-175-international-high-risk-clone-through-whole-genome-sequencing
#8
Gabriel Cabot, Carla López-Causapé, Alain A Ocampo-Sosa, Lea M Sommer, María Ángeles Domínguez, Laura Zamorano, Carlos Juan, Fe Tubau, Cristina Rodríguez, Bartolomé Moyà, Carmen Peña, Luis Martínez-Martínez, Patrick Plesiat, Antonio Oliver
Whole-genome sequencing (WGS) was used for the characterization of the frequently extensively drug resistant (XDR) Pseudomonas aeruginosa sequence type 175 (ST175) high-risk clone. A total of 18 ST175 isolates recovered from 8 different Spanish hospitals were analyzed; 4 isolates from 4 different French hospitals were included for comparison. The typical resistance profile of ST175 included penicillins, cephalosporins, monobactams, carbapenems, aminoglycosides, and fluoroquinolones. In the phylogenetic analysis, the four French isolates clustered together with two isolates from one of the Spanish regions...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27724984/differential-tlr-activation-of-murine-mesenchymal-stem-cells-generates-distinct-immunomodulatory-effects-in-eae
#9
Ana María Vega-Letter, Mónica Kurte, Catalina Fernández-O'Ryan, Melanie Gauthier-Abeliuk, Patricia Fuenzalida, Ivón Moya-Uribe, Claudia Altamirano, Fernando Figueroa, Carlos Irarrázabal, Flavio Carrión
BACKGROUND: Recently, it has been observed that mesenchymal stem cells (MSCs) can modulate their immunoregulatory properties depending on the specific in-vitro activation of different Toll-like receptors (TLR), such as TLR3 and TLR4. In the present study, we evaluated the effect of polyinosinic:polycytidylic acid (poly(I:C)) and lipopolysaccharide (LPS) pretreatment on the immunological capacity of MSCs in vitro and in vivo. METHODS: C57BL/6 bone marrow-derived MSCs were pretreated with poly(I:C) and LPS for 1 hour and their immunomodulatory capacity was evaluated...
October 10, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27721778/unresectable-recurrent-multiple-meningioma-a-case-report-with-radiological-response-to-somatostatin-analogues
#10
Ana Ortolá Buigues, Irene Crespo Hernández, Manuela Jorquera Moya, Jose Ángel Díaz Pérez
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed. In addition, these medications have been shown to have an antiproliferative and antiangiogenic effect in vitro. To date, very few cases with clinical response and none with radiological response have been described. The case described here is the first to report a radiological response...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27692089/immunoproteomic-characterization-of-a-dermatophagoides-farinae-extract-used-in-the-treatment-of-canine-atopic-dermatitis
#11
Raquel Moya, Jerónimo Carnés, Nuria Sinovas, Laura Ramió, Pilar Brazis, Anna Puigdemont
BACKGROUND: Canine atopic dermatitis is a pruritic allergic skin disease. House dust mites have been identified as the main non-seasonal responsible agent. Unlike in human allergic patients, groups 1 and 2 antigens have been described as minor allergens in dogs, while groups 15 and 18 are considered the major allergens. Despite these differences, allergic dogs have traditionally been treated using extracts intended for human immunotherapy. OBJECTIVES: To investigate the immunological characteristics and the allergen reactivity of dogs with atopic dermatitis using a Dermatophagoides farinae commercial extract...
November 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27666791/development-refractoriness-of-mll-rearranged-human-b-cell-acute-leukemias-to-reprogramming-into-pluripotency
#12
Alvaro Muñoz-López, Damià Romero-Moya, Cristina Prieto, Verónica Ramos-Mejía, Antonio Agraz-Doblas, Ignacio Varela, Marcus Buschbeck, Anna Palau, Xonia Carvajal-Vergara, Alessandra Giorgetti, Anthony Ford, Majlinda Lako, Isabel Granada, Neus Ruiz-Xivillé, Sandra Rodríguez-Perales, Raul Torres-Ruíz, Ronald W Stam, Jose Luis Fuster, Mario F Fraga, Mahito Nakanishi, Gianni Cazzaniga, Michela Bardini, Isabel Cobo, Gustavo F Bayon, Agustin F Fernandez, Clara Bueno, Pablo Menendez
Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming leukemias is an extremely inefficient process. Few studies generated iPSCs from primary chronic myeloid leukemias, but iPSC generation from acute myeloid or lymphoid leukemias (ALL) has not been achieved. We attempted to generate iPSCs from different subtypes of B-ALL to address the developmental impact of leukemic fusion genes...
October 11, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27649630/-giant-coronary-aneurysms-in-infants-with-kawasaki-disease
#13
Antonio Sánchez Andrés, Inmaculada Salvador Mercader, Julia Seller Moya, José Ignacio Carrasco Moreno
INTRODUCTION: Kawasaki disease (KD) is an acute vasculitis of unknown origin and predominant in males. The long-term effects of the disease depend on whether there are coronary lesions, particularly aneurysms. The prognosis of patients with giant aneurysms is very poor due to their natural progression to coronary thrombosis or severe obstructive lesions. OBJECTIVES: A series of 8 cases is presented where the epidemiology and diagnostic methods are described. The treatment of the acute and long-term cardiovascular sequelae is also reviewed...
September 16, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27645887/evaluation-of-onchocerciasis-seroprevalence-in-bioko-island-equatorial-guinea-after-years-of-disease-control-programmes
#14
Ana Hernández-González, Laura Moya, María J Perteguer, Zaida Herrador, Rufino Nguema, Justino Nguema, Pilar Aparicio, Agustín Benito, Teresa Gárate
BACKGROUND: Onchocerciasis or "river blindness" is a chronic parasitic disease caused by the filarial worm Onchocerca volvulus, transmitted through infected blackflies (Simulium spp.). Bioko Island (Equatorial Guinea) used to show a high endemicity for onchocerciasis. During the last years, the disease control programmes using different larvicides and ivermectin administration have considerably reduced the prevalence and intensity of infection. Based on this new epidemiological scenario, in the present work we aimed to assess the impact of the strategies applied against onchocerciasis in Bioko Island by an evaluation of IgG4 antibodies specific for recombinant Ov-16 in ELISA...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27608500/extended-high-frequency-audiometry-can-diagnose-sub-clinic-involvement-in-a-seemingly-normal-hearing-systemic-lupus-erythematosus-population
#15
Mar Lasso de la Vega, Ithzel María Villarreal, Julio López Moya, José Ramón García-Berrocal
CONCLUSIONS: Sensorineural hearing loss must be considered within the clinical picture of systemic lupus erythematosus. The results confirm the usefulness of extended high-frequency audiometry in the audiologic testing of these patients, enabling the possibility of modifying or applying a preventive treatment for a possible hearing loss. OBJECTIVES: Hearing involvement is usually under-diagnosed with routine auditory examination. This study proposes the use of extended high-frequency audiometry to achieve a correct detection of a possible asymptomatic hypoacusis in early stages of the disease...
September 9, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27600969/interferences-on-microbial-inhibitor-tests-related-to-ivermectin-treatment-in-lactating-dairy-goats
#16
Tamara Romero, Vicente Javier Moya, Nemesio Fernández, Rafael Althaus, Wim Reybroeck, María Pilar Molina
This Research Communication reports interferences related to the administration of ivermectin in lactating dairy goats on the response of microbial tests for screening antibiotics in milk. Twenty-eight Murciano-Granadina goats, naturally infested with Sarcoptes scabiei var. caprae, were treated with a subcutaneous injection of ivermectin (200 µg/kg b.w.). To prevent re-infestation, a second dose was applied 7 d later. Individual milk samples were collected, daily, up to 15 d post-treatment. Milk samples were analysed by microbial inhibitor tests (BRT MRL, Delvotest SP-NT MCS and Eclipse 100) and ivermectin residues were quantified by HPLC...
August 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27599267/relationship-among-risk-score-systems-and-coronary-atherosclerosis-determined-by-multislice-computed-tomography
#17
Alberto García-Lledó, José L Moya-Mur, Virginia Ponz-Mir, Susana Novo-Aparicio, Azucena Sanz-Barrio, Concepción Álvarez-Sanz, Ana de Santiago-Nocito
BACKGROUND: Risk score systems (RSS) were designed to estimate the risk of cardiac events. Their ability to predict coronary atherosclerosis (CA) has not been established. HYPOTHESIS: Risk score systems can predict presence of CA in patients without typical symptoms or ischemia. Because design of each RSS is different, their predictive value could also differ. METHODS: A retrospective analysis was done on patients from a low-risk region referred for cardiac multislice computed tomography (MSCT)...
September 6, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27509353/antimicrobial-activity-of-submicron-glass-fibres-incorporated-as-a-filler-to-a-dental-sealer
#18
L Esteban-Tejeda, B Cabal, R Torrecillas, C Prado, E Fernandez-Garcia, R López-Piriz, F Quintero, J Pou, J Penide, J S Moya
Two types of antimicrobial glass fibers containing ZnO and CaO, with diameters ranging from tens of nanometers to 1 µm, were successfully fabricated by a laser spinning technique. The antimicrobial performance was corroborated according to ISO 20743:2013, by using gram-negative (Escherichia coli) and gram-positive (Streptococcus oralis, Streptococcus mutans and Staphylococcus aureus) bacteria, and yeast (Candida krusei) (more than 3 logs of reduction). The metabolic activity and endosomal system of eukaryotic cells were not altered by using eluents of CaO glass submicrometric fibers and ZnO fibers at 1 : 10 dilution as cellular media (viability rates over 70%)...
2016: Biomedical Materials
https://www.readbyqxmd.com/read/27448085/evidence-for-suppression-of-onchocerciasis-transmission-in-bioko-island-equatorial-guinea
#19
Laura Moya, Zaida Herrador, Thuy Huong Ta-Tang, Jose Miguel Rubio, Maria Jesús Perteguer, Ana Hernandez-González, Belén García, Rufino Nguema, Justino Nguema, Policarpo Ncogo, Teresa Garate, Agustín Benito, Anacleto Sima, Pilar Aparicio
Onchocerciasis or "river blindness" is a chronic parasitic neglected tropical disease which is endemic both in mainland and insular Equatorial Guinea. We aim to estimate the current epidemiological situation of onchocerciasis in Bioko Island after vector elimination in 2005 and more than sixteen years of Community Directed Treatment with Ivermectin (CDTI) by using molecular and serological approaches for onchocerciasis diagnosis. A community-based cross-sectional study was carried out in Bioko Island from mid-January to mid-February 2014...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27445566/invasive-pulmonary-aspergillosis-with-disseminated-infection-in-immunocompetent-patient
#20
Gabriel Moreno-González, Antoni Ricart de Mesones, Rachid Tazi-Mezalek, Maria Teresa Marron-Moya, Antoni Rosell, Rafael Mañez
Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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