Emily A Sloan, Rohit Gupta, Christian Koelsche, Jason Chiang, Javier E Villanueva-Meyer, Sanda Alexandrescu, Jennifer M Eschbacher, Wesley Wang, Manuela Mafra, Nasir Ud Din, Emily Carr-Boyd, Michael Watson, Michael Punsoni, Angelica Oviedo, Ahmed Gilani, Bette K Kleinschmidt-DeMasters, Dylan J Coss, M Beatriz Lopes, Alyssa Reddy, Sabine Mueller, Soo-Jin Cho, Andrew E Horvai, Julieann C Lee, Melike Pekmezci, Tarik Tihan, Andrew W Bollen, Fausto J Rodriguez, David W Ellison, Arie Perry, Andreas von Deimling, Susan M Chang, Mitchel S Berger, David A Solomon
'Intracranial mesenchymal tumor, FET-CREB fusion-positive' occurs primarily in children and young adults and has previously been termed intracranial angiomatoid fibrous histiocytoma (AFH) or intracranial myxoid mesenchymal tumor (IMMT). Here we performed genome-wide DNA methylation array profiling of 20 primary intracranial mesenchymal tumors with FET-CREB fusion to further study their ontology. These tumors resolved into two distinct epigenetic subgroups that were both divergent from all other analyzed intracranial neoplasms and soft tissue sarcomas, including meningioma, clear cell sarcoma of soft tissue (CCS), and AFH of extracranial soft tissue...
July 2022: Brain Pathology