Elmar Kirches, Felix Sahm, Andrey Korshunov, Christina Bluecher, Natalie Waldt, Siegfried Kropf, Daniel Schrimpf, Philipp Sievers, Damian Stichel, Ulrich Schüller, Jens Schittenhelm, Markus J Riemenschneider, Matthias A Karajannis, Arie Perry, Torsten Pietsch, Svenja Boekhoff, David Capper, Katja Beck, Nagarajan Paramasivam, Matthias Schlesner, Priscilla K Brastianos, Hermann L Müller, Stefan M Pfister, Christian Mawrin
In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%])...
November 2021: Acta Neuropathologica