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chordoid meningioma

Anna S Berghoff, Philip Kresl, Michal Bienkowski, Christian Koelsche, Ursula Rajky, Johannes A Hainfellner, Matthias Preusser
INTRODUCTION: NAB2-STAT6 gene fusion is a molecular characteristic of solitary fibrous tumors (SFT) and hemangiopericytoma, underscoring their definition as one diagnostic entity. NAB2-STAT6 fusion is associated with nuclear relocation of STAT6 protein that can be detected by immunohistochemistry. We evaluated the diagnostic value of STAT6 expression in meningeal tumors. METHODS: 77 meningeal tumors (17/77 (22.0%) SFT/hemangiopericytoma, 11/77 meningothelial meningioma, 10/77 atypical meningioma 8/77 chordoid meningioma, 9/77 fibroblastic meningioma, 10/77 transitional meningioma, 3/77 rhabdoid meningioma and 9/77 anaplastic meningioma) were included...
March 2017: Clinical Neuropathology
Hirotaka Fudaba, Tatsuya Abe, Masaki Morishige, Yasutomo Momii, Kenji Kashima, Akira Yamada, Hirofumi Nagatomi, Atsushi Natsume, Junko Hirato, Yoichi Nakazato, Minoru Fujiki
A 46-year-old woman presented with headache and right hemiparesis. MRI demonstrated a mass in the left middle fossa. Total resection was performed. A histological examination of the tumor specimen showed several characteristic morphological features. A chordoid meningioma showing an epithelial-like palisade arrangement was observed. An anaplastic short spindle cell tumor exhibiting a fascicular pattern was considered to be a rhabdomyosarcoma. After conventional radiotherapy, the tumor was well controlled without any neurological deficit for 20 months...
December 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
José A Jiménez-Heffernan, Andrés Urquía-Renke, Carmen Bárcena, Javier Fraga
No abstract text is available yet for this article.
October 2016: Diagnostic Cytopathology
Yosef Laviv, Victoria Ohla, Ekkehard M Kasper
Meningiomas are some of the most frequently encountered adult intracranial tumors. Dramatic flare ups in size may occasionally be observed during pregnancy, leading to complicated clinical scenarios, with profound effects and substantial risks for both the mother's and the fetus's well-being. Despite the fact that such changes have largely been attributed to progesterone-based mechanisms, recent studies have put this theory into question or defied it. In order to assess these particular tumors carefully and to try and clarify the pathophysiology of such pregnancy-related meningioma growth, an in-depth review of the pertinent literature was undertaken...
June 16, 2016: Neurosurgical Review
Lain Hermes Gonzalez-Quarante, Fernando Ruiz-Juretschke, Begoña Iza-Vallejo, Esteban Scola-Pliego, Daniel Poletti, Emma Sola Vendrell
BACKGROUND: Meningiomas without dural attachment (MWODA) located in the posterior fossa are an unfrequent entity. They are usually located in the fourth ventricle, and their occurrence outside of this anatomic structure is an even more uncommon finding. Chordoid meningiomas are a rare subtype of meningioma, and they have been reported to account for 0.5%-1% of all meningiomas. CASE DESCRIPTION: We report the unusual case of a 36-year-old female patient, with unremarkable past medical history, who presented at our institution complaining of acute binocular diplopia...
July 2016: World Neurosurgery
Yang Yang, Da Li, Xiao-Yu Cao, Shu-Yu Hao, Liang Wang, Zhen Wu, Jun-Ting Zhang
OBJECTIVE: As one subtype of meningiomas, chordoid meningiomas (CMs) are rarely described. In this study, the authors aimed to analyze the incidence, clinical features, treatment, and prognostic factors of CMs. METHODS: Among 9873 cases of meningioma surgically treated between 2003 and 2013 at Beijing Tiantan Hospital, cases of CM were chosen for analysis and were reviewed retrospectively. To ascertain which factors were related with progression-free survival (PFS), statistical analysis was performed...
September 2016: World Neurosurgery
Junmei Wang, Zhaoxia Liu, Jiang Du, Yun Cui, Jingyi Fang, Li Xu, Guilin Li
Pituicytoma is rare and difficult to diagnose. This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33-65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6-month period...
October 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Liang Wu, Tao Yang, Jingyi Fang, Junting Zhang, Yulun Xu
As an uncommon subtype of meningioma, chordoid meningioma (CM) of the spinal canal is extremely rare. There have been only two reported cases of intraspinal CM in the literature, and this lesion has not been previously reported in the pediatric age group. To the best of our knowledge, the present study reports the first case of spinal chordoid meningioma in a pediatric patient. A 12-year-old female presented with a 3-month history of progressive numbness and weakness in the right-side limbs, and intermittent pain in the neck and right shoulder...
December 2015: Oncology Letters
Mónica B Mezmezian, Mónica B Carassai, Valeria Dopazo, María L Deforel, María Á Puzzo
INTRODUCTION: Immunostaining of progesterone receptors (PRs) has been described as a prognostic factor related to recurrences in meningiomas. However, its expression in other primary intracranial tumors has been poorly studied. In this paper, we compare the pattern of expression of the receptor in meningiomas with that of nonmeningothelial intracranial tumors to evaluate its value in the diagnosis of the former. MATERIALS AND METHODS: A total of 42 nonmeningothelial intracranial tumors (21 glioblastomas, 4 anaplastic oligodendrogliomas, 4 oligodendrogliomas, 1 pilomyxoid astrocytoma, 3 ependymomas, 8 schwannomas, 1 chordoid chordoma) and 32 meningiomas (1 rhabdoid, 1 papillary, 5 atypical, 7 with histologic features of more aggressive behavior, 1 microcyst, 8 meningothelial, 7 transitional, 2 fibroblastic) were studied for PR by immunohistochemistry...
January 13, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Winward Choy, Leonel Ampie, Jonathan B Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T Parsa, Orin Bloch
No abstract text is available yet for this article.
October 22, 2015: Journal of Neuro-oncology
Fouzia Siraj, Mariya K Ansari, K C Sharma, Avninder Singh
Chordoid meningioma (CM), classified as Grade II/atypical meningioma according to the World Health Organization classification, is a rare subtype, which represents only 0.5% of all meningiomas. Morphologically, it can mimic other chondroid and myxoid tumors within the brain and its vicinity thus posing a diagnostic challenge. Accurate diagnosis, therefore, assumes importance as these tumors have an aggressive clinical course and propensity to recur compared to classical meningiomas. Furthermore, the prognosis and treatment strategies vary when compared to tumors with morphological overlap...
July 2015: Journal of Cancer Research and Therapeutics
Winward Choy, Leonel Ampie, Jonathan B Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T Parsa, Orin Bloch
Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms "chordoid" AND "meningioma" was performed to identify all reports of pathologically confirmed intracranial CMs...
January 2016: Journal of Neuro-oncology
S Zouaoui, A Darlix, V Rigau, H Mathieu-Daudé, F Bauchet, F Bessaoud, P Fabbro-Peray, B Trétarre, D Figarella-Branger, L Taillandier, H Loiseau, L Bauchet
PURPOSE: This work describes the clinical epidemiology and pathology for patients undergoing surgery for newly diagnosed meningiomas in France between 2006 and 2010. METHODS: The methodology is based on a multidisciplinary national network previously established by the French Brain Tumor DataBase (FBTDB) (in French: Recensement national histologique des tumeurs primitives du système nerveux central [RnhTPSNC]), and the active participation of the scientific societies involved in neuro-oncology in France...
June 11, 2015: Neuro-Chirurgie
Daniele Bongetta, Andrea Risso, Patrizia Morbini, Giorgio Butti, Paolo Gaetani
Chordoid glioma (CG) is a rare central nervous system neoplasm (WHO grade II) of uncertain origin whose typical localization is in the anterior part of the third ventricle. Its clinical, radiological, and histological features may vary and furthermore mimic other kind of benign lesions usually associated with a better outcome. We report a case of a 43-year-old female who underwent gross total removal of a lesion of the third ventricle causing hydrocephalus. The imaging studies and the intraoperative examination led at first to a hypothesis of meningioma...
2015: World Journal of Surgical Oncology
J B Pond, T G Morgan, K J Hatanpaa, Z F Yetkin, B E Mickey, D B Mendelsohn
BACKGROUND AND PURPOSE: Meningiomas are very commonly diagnosed intracranial primary neoplasms, of which the chordoid subtype is seldom encountered. Our aim was to retrospectively review preoperative MR imaging of intracranial chordoid meningiomas, a rare WHO grade II variant, in an effort to determine if there exist distinguishing MR imaging characteristics that can aid in differentiating this atypical variety from other meningioma subtypes. MATERIALS AND METHODS: Ten cases of WHO grade II chordoid meningioma were diagnosed at our institution over an 11-year span, 8 of which had preoperative MR imaging available for review and were included in our analysis...
July 2015: AJNR. American Journal of Neuroradiology
Valeria Barresi, Giovanni Branca, Maria Caffo, Giovanni Tuccari
Despite total surgical resection, a percentage of meningiomas do unexpectedly recur. At present the prediction of recurrence risk and the management of recurrent tumours represent major issues in the patients affected by meningiomas. The present study aims at investigating the prognostic value of the expression of the phosphorylated transcription factor cyclic AMP responsive element binding protein (p-CREB) in a series of meningiomas of different histotype and grade. While no p-CREB expression was found in specimens of normal leptomeninges, 71 % of meningiomas in our cohort expressed p-CREB...
March 2015: Journal of Neuro-oncology
Antonio Di Ieva, Simin Laiq, Romina Nejad, Erika M Schmitz, Hussein Fathalla, Jason Karamchandani, David G Munoz, Michael D Cusimano
Chordoid meningioma (CM) is a rare subtype of meningioma, classified as grade II, which exhibits a high rate of recurrence following subtotal resection. We retrospectively examined nine cases of chordoid meningioma over a case series of 1743 meningiomas (0.52%) operated upon at our institution from 1995 to 2013. All the reported clinicopathological findings were analyzed. Two hundred and twenty-one CM cases have been published to date worldwide and few single-center large case series have been issued. Seventy-five percent of the cases that underwent subtotal resection at our institution had recurrence within 1 year...
April 2015: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Tae Keun Jee, Kyung-Il Jo, Ho Jun Seol, Doo-Sik Kong, Jung-Il Lee, Hyung Jin Shin
OBJECTIVE: Meningioma is the second most common primary central nervous system neoplasm. In contrast, chordoid meningioma is rare; due to the paucity of cases, little is known about its clinical features or treatment outcomes. The objectives of this study were to describe the clinical characteristics and outcomes for patients with chordoid meningioma. METHODS: In total, 16 patients, with newly diagnosed chordoid meningioma who underwent surgical excision between 1999 and 2012 were included...
September 2014: Journal of Korean Neurosurgical Society
Jiwon Lee, Hee Joon Yu, Jeehun Lee, Ji Hye Kim, Hyung Jin Shin, Yeon-Lim Suh, Munhyang Lee
No abstract text is available yet for this article.
August 2014: Korean Journal of Pathology
Hatice Özer, Ersin Tuncer, Gönül Saray, Mustafa Gürelik, İbrahim Öztoprak, Reyhan Eğilmez
Meningiomas are tumors that originate from the arachnoid cell and the majority are benign and grade I tumors according to World Health Organization. Chordoid meningioma is an uncommon variant of meningioma and corresponds to grade II tumor in the World Health Organization Classification of Tumors of the Nervous System 2007 because of its more aggressive behavior and increased likelihood of recurrence. A 75-year-old female was referred to the neurosurgery department complaining of headache, syncope, and seizure...
2016: Türk Patoloji Dergisi
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