keyword
MENU ▼
Read by QxMD icon Read
search

Anti-angiogenesis

keyword
https://www.readbyqxmd.com/read/28106052/tanshinone-iia-induces-intrinsic-apoptosis-in-osteosarcoma-cells-both-in-vivo-and-in-vitro-associated-with-mitochondrial-dysfunction
#1
Sheng-Teng Huang, Chao-Chun Huang, Wen-Liang Huang, Tsu-Kung Lin, Pei-Lin Liao, Pei-Wen Wang, Chia-Wei Liou, Jiin-Haur Chuang
Tanshinone IIA (Tan IIA), a phytochemical derived from the roots of Salvia miltiorrhiza, has been shown to inhibit growth and induce apoptosis in various cancer cells. The association of its inhibitory effect on the primary malignant bone tumor, osteosarcoma, with mitochondrial dysfunction remains unclear. This study aimed to investigate the anti-proliferative effects of Tan IIA on human osteosarcoma 143B cells both in vitro and in vivo. Administration of Tan IIA to NOD-SCID mice implanted with 143B cells led to significant inhibition of tumor development...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105231/pigment-epithelium-derived-factor-has-a-role-in-the-progression-of-papillary-thyroid-carcinoma-by-affecting-the-hif1%C3%AE-vegf-signaling-pathway
#2
Yichen Lv, Yu Sun, Tiefeng Shi, Chenlei Shi, Huadong Qin, Zhaozhu Li
The progression mechanism of papillary thyroid carcinoma (PTC) remains largely unknown. Accumulating evidence has suggested that various targets of pigment epithelium-derived factor (PEDF) are able to inhibit cancer progression. The aim of the present study was to examine PEDF expression in PTC patients and to investigate its relationship with aggressive clinicopathological features, as well as to explore whether PEDF affects the progression of PTC via the hypoxia-inducible factor 1α (HIF1α)-vascular endothelial growth factor (VEGF) pathway...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28098907/synergistic-combination-of-ys-1-and-adriamycin-inhibits-human-renal-cancer-through-erk1-2-signaling-pathway-in%C3%A2-vitro-and-in%C3%A2-vivo
#3
Xiaowen Yu, Qingqing Yang, Sensen Lin, Shengtao Yuan, Li Sun
Adriamycin (ADM) is a principal drug for the treatment of renal cell cancer (RCC). Due to its limited response and high renal and cardiac toxicity, synergistic effects of ADM in combination with other drugs have been widely researched. In this study, we found the combination between YS-1 and ADM, performed higher anticancer activity on 786-O human RCC cells in vitro and in vivo, than that reported on its anti-angiogenesis effect compared with monotherapy of ADM. Our data showed that when combined with ADM, YS-1 promoted the sensitivity of 786-O cells to ADM...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098802/penduliflaworosin-a-diterpenoid-from-croton-crassifolius-exerts-anti-angiogenic-effect-via-vegf-receptor-2-signaling-pathway
#4
Yeyin Liang, Yubo Zhang, Guocai Wang, Yaolan Li, Weihuan Huang
Anti-angiogenesis targeting vascular endothelial growth factor receptor-2 (VEGFR-2) has been considered as an important strategy for cancer therapy. Penduliflaworosin is a diterpenoid isolated from the plant Croton crassifolius. Our previous study showed that this diterpenoid possesses strong anti-angiogenic activity by inhibiting vessel formation in zebrafish. This study was conducted to further investigate the anti-angiogenic activity and mechanism of penduliflaworosin. Results revealed that penduliflaworosin significantly inhibited VEGF-induced angiogenesis processes including proliferation, invasion, migration, and tube formation of human umbilical vein endothelial cells (HUVECs)...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28089416/strategies-to-overcome-therapeutic-resistance-in-renal-cell-carcinoma
#5
REVIEW
Peter J Siska, Kathryn E Beckermann, W Kimryn Rathmell, Scott M Haake
BACKGROUND: Renal cell cancer (RCC) is a prevalent and lethal disease. At time of diagnosis, most patients present with localized disease. For these patients, the standard of care includes nephrectomy with close monitoring thereafter. While many patients will be cured, 5-year recurrence rates range from 30% to 60%. Furthermore, nearly one-third of patients present with metastatic disease at time of diagnosis. Metastatic disease is rarely curable and typically lethal. Cytotoxic chemotherapy and radiation alone are incapable of controlling the disease...
January 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28071720/polychlorinated-biphenyls-target-notch-dll-and-vegf-r2-in-the-mouse-placenta-and-human-trophoblast-cell-lines-for-their-anti-angiogenic-effects
#6
Satyan Kalkunte, Zheping Huang, Eliana Lippe, Sunil Kumar, Larry W Robertson, Surendra Sharma
The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects were observed in IL-10(-/-), but not wild type, mice, suggesting that IL-10 deficiency predisposes to pregnancy disruptive effects of environmental toxicants. However, the mechanisms by which PCBs cause anti-angiogenic effects are unclear...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068599/discovery-of-novel-anti-angiogenesis-agents-part-6-multi-targeted-rtk-inhibitors
#7
Lin Zhang, Yuanyuan Shan, Chuansheng Li, Ying Sun, Ping Su, Jinfeng Wang, Lisha Li, Xiaoyan Pan, Jie Zhang
Angiogenesis is modulated by a multitude of pro-angiogenic factors including VEGFR-2, Tie-2, and EphB4. Moreover, their crosstalk also had been well elaborated. We have identified several diarylurea-based VEGFR-2 inhibitors as potential anti-angiogenesis agents. As a continuation to our previous research, two series of diaryl malonamide and diaryl thiourea derivatives have been developed as multiplex VEGFR-2/Tie-2/EphB4 inhibitors. Interestingly, the biological evaluation indicated that several compounds bearing trifluoromethyl or trifluoromethoxyl exhibited promising multiplex inhibition against angiogenesis-related VEGFR-2, Tie-2, and EphB4...
January 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28056756/vascular-endothelial-growth-factor-vegf-signaling-in-tumour-vascularization-potential-and-challenges
#8
Kodappully Sivaraman Siveen, Kirti Prabhu, Roopesh Krishnankutty, Shilpa Kuttikrishnan, Magdalini Tsakou, Feras Q Alali, Said Dermime, Ramzi M Mohammad, Shahab Uddin
Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies to manage the growth and metastasis of cancers. The functional and proliferative status of blood vessels is regulated by the balance between various key molecules that either stimulate or inhibit angiogenesis. During quiescence, the "angiogenic switch" is "off". However, during tumour development pro-angiogenic factors such as vascular endothelial growth factor (VEGF), basic and acidic fibroblast growth factor, tumour necrosis factor-α and interleukin-1 are pathologically enhanced...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28047007/we-de-bra-03-construction-of-an-ultrasound-guidance-platform-for-image-guided-radiotherapy-with-the-intent-to-treat-transitional-cell-carcinoma
#9
J Sick, N Rancilio, C Fulkerson, P LaPetina, J Poulson, D Knapp, K Stantz
PURPOSE: Ultrasound (US) is a noninvasive, nonradiographic imaging technique with high spatial and temporal resolution that can be used for localizing soft-tissue structures and tumors in real-time during radiotherapy (inter- and intra-fraction). A detailed methodology integrating 3D-US within RT is presented. This method is easier to adopt into current treatment protocol than current US based systems and reduces user variability for image acquisition, thus eliminating transducer induced changes that limit CT planning system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046833/su-f-j-155-evaluation-of-transcytolemmal-water-exchange-analysis-for-therapeutic-response-assessment-using-dynamic-contrast-enhanced-mri
#10
C Wang, E Subashi, X Liang, F Yin, Z Chang
PURPOSE: To compare the performance of shutter-speed(SS) model with transcytolemmal water exchange analysis against the Tofts model in the study of the efficacy of an anti-angiogenesis drug METHODS: 16 mice with LS-174T implanted were randomly assigned into treatment/control groups (n=8/group) and received bevacizumab/saline three times (Day1/Day4/Day8). All mice received one pre- (Day0) and two post-treatment (Day2/Day9) DCE scans. For each scan, the CA extravasation rate constant KT(trans) /KS(trans) from the Tofts/SS model were calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042341/anti-angiogenic-nanotherapy-inhibits-airway-remodeling-and-hyper-responsiveness-of-dust-mite-triggered-asthma-in-the-brown-norway-rat
#11
Gregory M Lanza, John Jenkins, Anne H Schmieder, Aigul Moldobaeva, Grace Cui, Huiying Zhang, Xiaoxia Yang, Qiong Zhong, Jochen Keupp, Ismail Sergin, Krishna S Paranandi, Lindsey Eldridge, John S Allen, Todd Williams, Michael J Scott, Babak Razani, Elizabeth M Wagner
Although angiogenesis is a hallmark feature of asthmatic inflammatory responses, therapeutic anti-angiogenesis interventions have received little attention. Objective: Assess the effectiveness of anti-angiogenic Sn2 lipase-labile prodrugs delivered via αvβ3-micellar nanotherapy to suppress microvascular expansion, bronchial remodeling, and airway hyper-responsiveness in Brown Norway rats exposed to serial house dust mite (HDM) inhalation challenges. Results: Anti-neovascular effectiveness of αvβ3-mixed micelles incorporating docetaxel-prodrug (Dxtl-PD) or fumagillin-prodrug (Fum-PD) were shown to robustly suppress neovascular expansion (p<0...
2017: Theranostics
https://www.readbyqxmd.com/read/28042312/antitumor-therapeutic-application-of-self-assembled-rnai-aunp-nanoconstructs-combination-of-vegf-rnai-and-photothermal-ablation
#12
Sejin Son, Namho Kim, Dong Gil You, Hong Yeol Yoon, Ji Young Yhee, Kwangmeyung Kim, Ick Chan Kwon, Sun Hwa Kim
Nucleic acid-directed self-assembly provides an attractive method to fabricate prerequisite nanoscale structures for a wide range of technological applications due to the remarkable programmability of DNA/RNA molecules. In this study, exquisite RNAi-AuNP nanoconstructs with various geometries were developed by utilizing anti-VEGF siRNA molecules as RNAi-based therapeutics in addition to their role as building blocks for programmed self-assembly. In particular, the anti-VEGF siRNA-functionalized AuNP nanoconstructs can take additional advantage of gold-nanoclusters for photothermal cancer therapeutic agent...
2017: Theranostics
https://www.readbyqxmd.com/read/28040437/cryptotanshinone-inhibits-vegf-induced-angiogenesis-by-targeting-the-vegfr2-signaling-pathway
#13
Xiaoming Xu, Li Wu, Xinbin Zhou, Nanyang Zhou, Qin Zhuang, Jinxiu Yang, Jin Dai, Haibing Wang, Shenjie Chen, Wei Mao
OBJECTIVE: Anti-angiogenesis has been proposed as an important strategy for angiogenesis-related diseases. Cryptotanshinone (CPT), an active component of Salvia miltiorrhiza, may be a potential inhibitor of angiogenesis. However, the molecular mechanisms underlying its anti-angiogenic activities remain poorly understood. This study is to investigate the effects of CPT on VEGF-induced angiogenesis and VEGFR2 signaling pathway in human umbilical vein endothelial cells (HUVECs). METHODS: HUVECs were treated with different concentration of CPT (5-20μmol/L) and the viability, endothelial cell migration, invasion, and tubular-like structure formation of HUVECs were detected by MTT, wound-healing migration, Transwell invasion and Matrigel tube formation assays, respectively...
December 28, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28039440/delivery-of-sfit-1-engineered-mscs-in-combination-with-a-continuous-low-dose-doxorubicin-treatment-prevents-growth-of-liver-cancer
#14
Jian Niu, Yue Wang, Ji Wang, Liu Bin, Xin Hu
One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs (Mesenchymal stem cells) can infiltrate into tumor tissue and function as the efficient transgene delivery mediator. Here, we engineered murine MSCs to express sFlt1 and examined the anti-tumor effect of MSC- sFlt1 in combination with continues low-dose doxorubicin treatment...
December 28, 2016: Aging
https://www.readbyqxmd.com/read/28029338/vasculogenic-mimicry-in-malignant-mesothelioma-an-experimental-and-immunohistochemical-analysis
#15
Emily Pulford, Ashleigh Hocking, Kim Griggs, James McEvoy, Claudine Bonder, Douglas W Henderson, Sonja Klebe
Vasculogenic mimicry, the process in which cancer cells form angiomatoid structures independent of or in addition to host angiogenesis has been recorded in several otherwise non-endothelial malignant neoplasms. This study describes evidence of routine vascular mimicry by human mesothelioma cell lines in vitro, when the cell lines are cultured alone or co-cultured with human umbilical vascular endothelial cells, with the formation of angiomatoid tubular networks. Vasculogenic mimicry is also supported by immunohistochemical demonstration of human-specific anti-mitochondria antibody labelling of tumour-associated vasculature of human mesothelioma cells xenotransplanted into nude mice, and by evidence of vascular mimicry in some biopsy samples of human malignant mesotheliomas...
October 28, 2016: Pathology
https://www.readbyqxmd.com/read/28005980/the-prognosis-of-anti-angiogenesis-treatments-combined-with-standard-therapy-for-newly-diagnosed-glioblastoma-a-meta-analysis-of-randomized-controlled-trials
#16
Yuping Li, Mengzhuo Hou, Guangyu Lu, Natalia Ciccone, Xingdong Wang, Hengzhu Zhang
BACKGROUND AND PURPOSE: Although bevacizumab (BV) has been approved as second-line therapy for recurrent glioblastoma (GB), the efficacy and safety of BV for patients with newly diagnosed GB remain unclear. METHODOLOGY/PRINCIPAL FINDINGS: We systematically searched electronic databases (PubMed, EMBASE, OVID, etc.) to identify related studies published from January 1966 and August 2016. Eight randomized controlled trials including a total of 2,185 patients with GB were included...
2016: PloS One
https://www.readbyqxmd.com/read/28001083/nrf2-targeting-by-sulforaphane-a-potential-therapy-for-cancer-treatment
#17
Maria Russo, Carmela Spagnuolo, Gian Luigi Russo, Krystyna Skalicka-Woźniak, Maria Daglia, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Seyed Mohammad Nabavi
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. In this review, we discuss the available experimental and clinical data on the potential therapeutic role of sulforaphane against cancer...
December 21, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27999372/triptolide-combined-with-radiotherapy-for-the-treatment-of-nasopharyngeal-carcinoma-via-nf-%C3%AE%C2%BAb-related-mechanism
#18
Weiying Zhang, Min Kang, Tingting Zhang, Bo Li, Xueyin Liao, Rensheng Wang
Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis because of the lack of an effective treatment. Here we explored the efficiency and the molecular mechanisms of combined treatment with triptolide and ionizing radiation for treating NPC. Human nasopharyngeal carcinoma (CNE) cells were treated with triptolide, ionizing radiation, or triptolide plus ionizing radiation in vitro. Tumor potency was examined in an in vivo CNE cell xenograft mouse model, which was treated as above. Our results demonstrated that triptolide caused a significant reduction in cell growth and colony number, and induced a marked apoptosis that was further enhanced with increasing doses of ionizing radiation...
December 19, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27998073/matrix-metalloproteinase-responsive-nanoparticles-for-synergistic-treatment-of-colorectal-cancer-via-simultaneous-anti-angiogenesis-and-chemotherapy
#19
Leilei Shi, Yi Hu, Ang Lin, Chuan Ma, Chuan Zhang, Yue Su, Linzhu Zhou, Yumei Niu, Xinyuan Zhu
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide, especially in developed countries. Although patients' overall survival has been improved by either conventional chemotherapy or newly developed anti-angiogenesis treatment based on its highly vascularized feature, the relatively low therapeutic efficacy and severe side effects remain big problems in clinical practice. In this study, we describe an easy method to construct a novel matrix metalloproteinase-2 (MMP-2) responsive nanocarrier, which can load hydrophobic agents (camptothecin and sorafenib) with high efficiency to exert synergistic efficacy for CRC treatment...
December 21, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27996164/neoalbaconol-inhibits-angiogenesis-and-tumor-growth-by-suppressing-egfr-mediated-vegf-production
#20
Xinfang Yu, Wei Li, Qipan Deng, Shuo You, Haidan Liu, Songling Peng, Xiaolan Liu, Jingchen Lu, Xiangjian Luo, Lifang Yang, Min Tang, Xinxian Weng, Wei Yi, Wenbin Liu, Shengqi Wu, Zhihui Ding, Tao Feng, Jian Zhou, Jia Fan, Ann M Bode, Zigang Dong, Jikai Liu, Ya Cao
Neoalbaconol, derived from Albatrellus confluens, shows anti-cancer activities in the previously study, but its role in angiogenesis is unknown. Here, we determined whether neoalbaconol could attenuate angiogenesis and how does it occur. Data demonstrated that neoalbaconol could inhibit the proliferation of breast cancer cells and induce apoptosis. Also, neoalbaconol suppressed vascular endothelial growth factor (VEGF)-induced human umbilical vascular endothelial cells (HUVECs) proliferation, migration, invasion, and capillary-like tube formation in vitro and reduced tumor angiogenesis in vivo...
December 20, 2016: Molecular Carcinogenesis
keyword
keyword
47044
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"