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Neurocognitive testing

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https://www.readbyqxmd.com/read/28343463/prospective-head-to-head-study-of-three-computerized-neurocognitive-assessment-tools-part-2-utility-for-assessment-of-mild-traumatic-brain-injury-in-emergency-department-patients
#1
Lindsay D Nelson, Robyn E Furger, Peter Gikas, E Brooke Lerner, William B Barr, Thomas A Hammeke, Christopher Randolph, Kevin Guskiewicz, Michael A McCrea
OBJECTIVES: The aim of this study was to evaluate the reliability and validity of three computerized neurocognitive assessment tools (CNTs; i.e., ANAM, DANA, and ImPACT) for assessing mild traumatic brain injury (mTBI) in patients recruited through a level I trauma center emergency department (ED). METHODS: mTBI (n=94) and matched trauma control (n=80) subjects recruited from a level I trauma center emergency department completed symptom and neurocognitive assessments within 72 hr of injury and at 15 and 45 days post-injury...
March 27, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28342945/cognitive-impairment-in-first-episode-drug-na%C3%A3-ve-patients-with-schizophrenia-relationships-with-serum-concentrations-of-brain-derived-neurotrophic-factor-and-glial-cell-line-derived-neurotrophic-factor
#2
Wenhuan Xiao, Fei Ye, Chunlai Liu, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naïve (FEDN) patients with schizophrenia. METHODS: The BDNF and GDNF levels of 58 FEDN patients and 55 age- and sex-matched healthy controls were measured and test subjects were examined using several neurocognitive tests including the verbal fluency test (VFT), the trail making test (TMT), the digit span test (DST), and the Stroop test...
March 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28341527/the-relationship-of-maternal-prepregnancy-body-mass-index-and-pregnancy-weight-gain-to-neurocognitive-function-at-age-10-years-among-children-born-extremely-preterm
#3
Elizabeth T Jensen, Jelske W van der Burg, Thomas M O'Shea, Robert M Joseph, Elizabeth N Allred, Tim Heeren, Alan Leviton, Karl C K Kuban
OBJECTIVE: To assess the association between maternal prepregnancy body mass index and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm. STUDY DESIGN: Study participants were 535 ten-year-old children enrolled previously in the prospective multicenter Extremely Low Gestational Age Newborns cohort study who were products of singleton pregnancies. Soon after delivery, mothers provided information about prepregnancy weight...
March 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28340442/neurocognitive-performance-as-an-endophenotype-for-mood-disorder-subgroups
#4
Alison K Merikangas, Lihong Cui, Monica E Calkins, Tyler M Moore, Ruben C Gur, Raquel E Gur, Kathleen R Merikangas
BACKGROUND: There is growing evidence that neurocognitive function may be an endophenotype for mood disorders. The goal of this study is to examine the specificity and familiality of neurocognitive functioning across the full range of mood disorder subgroups, including Bipolar I (BP-I), Bipolar II (BP-II), Major Depressive Disorders (MDD), and controls in a community-based family study. METHODS: A total of 310 participants from 137 families with mood spectrum disorders (n=151) and controls (n=159) completed the University of Pennsylvania's Computerized Neurocognitive Battery (CNB) that assessed the accuracy and speed of task performance across five domains...
March 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28336195/cognitive-correlates-of-visual-neural-plasticity-in-schizophrenia
#5
Carol Jahshan, Jonathan K Wynn, Daniel H Mathalon, Michael F Green
Neuroplasticity may be an important treatment target to improve the cognitive deficits in schizophrenia (SZ). Yet, it is poorly understood and difficult to assess. Recently, a visual high-frequency stimulation (HFS) paradigm that potentiates electroencephalography (EEG)-based visual evoked potentials (VEP) has been developed to assess neural plasticity in the visual cortex. Using this paradigm, we examined visual plasticity in SZ patients (N=64) and its correlations with clinical symptoms, neurocognition, functional capacity, and community functioning...
March 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28335872/cognitive-impairment-in-euthymic-pediatric-bipolar-disorder-a-systematic-review-and-meta-analysis
#6
REVIEW
Liana R Elias, Kamilla W Miskowiak, Antônio M O Vale, Cristiano A Köhler, Hanne L Kjærstad, Brendon Stubbs, Lars V Kessing, Eduard Vieta, Michael Maes, Benjamin I Goldstein, André F Carvalho
OBJECTIVE: To perform a systematic review and meta-analysis of studies investigating neurocognition in euthymic youths with bipolar disorder (BD) compared to healthy controls (HCs). METHOD: A systematic literature search was conducted in the PubMed/MEDLINE, PsycINFO, and EMBASE databases from inception up until March 23, 2016, for original peer-reviewed articles that investigated neurocognition in euthymic youths with BD compared to HCs. Effect sizes (ES) for individual tests were extracted...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28334687/neurocognitive-status-in-patients-with-newly-diagnosed-brain-tumors-in-good-neurological-condition-the-impact-of-tumor-type-volume-and-location
#7
Philipp Hendrix, Elisa Hans, Christoph J Griessenauer, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Neurocognitive function is of great importance in patients with brain tumors. Even patients in good neurological condition may suffer from neurocognitive dysfunction that affects their daily living. The purpose of the present study was to identify risk factors for neurocognitive dysfunction in patients suffering from common supratentorial brain tumors with minor neurological deficits. METHODS: A prospective study evaluating neurocognitive dysfunction in patients with a newly-diagnosed brain tumor in good neurological condition was performed at a major German academic institution...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28334676/manual-motor-speed-dysfunction-as-a-neurocognitive-endophenotype-in-euthymic-bipolar-disorder-patients-and-their-healthy-relatives-evidence-from-a-5-year-follow-up-study
#8
P Correa-Ghisays, V Balanzá-Martínez, G Selva-Vera, J Vila-Francés, E Soria-Olivas, J Vivas-Lalinde, C San Martín, A M Borrás, R Ayesa-Arriola, J Sanchez-Moreno, J Sánchez-Ort, B Crespo-Facorro, E Vieta, R Tabarés-Seisdedos
BACKGROUND: Few studies have examined Manual Motor Speed (MMS) in bipolar disorder (BD). The aim of this longitudinal, family study was to explore whether dysfunctional MMS represents a neurocognitive endophenotype of BD. METHODS: A sample of 291 subjects, including 131 BD patients, 77 healthy first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy controls (HC), was assessed with the Finger-Tapping Test (FTT) on three occasions over a 5-year period...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28334488/the-metacognition-assessment-scale-mas-a-results-of-a-pilot-study-applying-a-german-translation-to-individuals-with-schizophrenia-spectrum-disorders
#9
Anna-Lena Bröcker, Samuel Bayer, Frauke Stuke, Patrick Giemsa, Andreas Heinz, Felix Bermpohl, Paul H Lysaker, Christiane Montag
OBJECTIVES: Metacognition, the capacity 'to think about thinking' and thus to reflect and to master interpersonal problems on a mentalistic basis, is often impaired among patients with schizophrenia spectrum disorders and has been suggested as a potential treatment target. However, little is known about the reliability of its measurement and links with related phenomena. The aim of this study was to validate a German translation of the Metacognition Assessment Scale (MAS-A) as a measure to assess metacognition from free narratives of patients' personally relevant episodes and relationships...
March 23, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28333901/influence-of-the-recurrent-syncope-episodes-on-neurocognitive-functions-in-patients-with-vasovagal-syncope
#10
Joanna Jędrzejczyk-Spaho, Artur Z Pietrucha, Agnieszka Borowiec, Irena Bzukała, Mateusz Wnuk, Ewa Konduracka, Jadwiga Nessler
The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. AIM: The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. MATERIALS AND METHODS: Study population: 24 pts. (16 women) aged 17-70 yrs (mean age 40 years), with suspected VVS, referred to HUTT (head-up tilt test). All pts. underwent initial evaluation regarding to the number and circumstances of the syncopal and/or presyncopal spells...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28333487/adaptation-of-the-arizona-cognitive-task-battery-for-use-with-the-ts65dn-mouse-model-mus-musculus-of-down-syndrome
#11
Michael R Hunsaker, Genevieve K Smith, Raymond P Kesner
We propose and validate a clear strategy to efficiently and comprehensively characterize neurobehavioral deficits in the Ts65Dn mouse model of Down syndrome. This novel approach uses neurocognitive theory to design and select behavioral tasks that test specific hypotheses concerning the results of Down syndrome. In this article, we model the Arizona Cognitive Task Battery, used to study human populations with Down syndrome, in Ts65Dn mice. We observed specific deficits for spatial memory, impaired long-term memory for visual objects, acquisition and reversal of motor responses, reduced motor dexterity, and impaired adaptive function as measured by nesting and anxiety tasks...
March 23, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28329864/age-differences-in-cognitive-and-affective-theory-of-mind-concurrent-contributions-of-neurocognitive-performance-sex-and-pulse-pressure
#12
Ashley L Fischer, Norm O'Rourke, Wendy Loken Thornton
Objectives: Theory of mind (ToM) allows us to detect and make inferences about cognitive and affective mental states. Mixed findings exist regarding (a) age differences in cognitive and affective ToM and (b) what mechanisms may underlie changes in the two components. We addressed these questions by examining the unique and joint contributions of neurocognitive performance, pulse pressure (PP), and biological sex to age differences in cognitive and affective ToM. Method: We tested 86 young and 85 older adults on standardized measures of neurocognitive performance and ToM...
August 7, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28328547/predictors-and-impact-of-self-reported-suboptimal-effort-on-estimates-of-prevalence-of-hiv-associated-neurocognitive-disorders
#13
Andrew J Levine, Eileen Martin, Ned Sacktor, Cynthia Munro, James Becker
BACKGROUND: Prevalence estimates of HIV-associated neurocognitive disorders (HAND) may be inflated. Estimates are determined via cohort studies in which participants may apply suboptimal effort on neurocognitive testing, thereby inflating estimates. Additionally, fluctuating HAND severity over time may be related to inconsistent effort. To address these hypotheses, we characterized effort in the Multicenter AIDS Cohort Study. METHODS: After neurocognitive testing, 935 participants (525 HIV-, 410 HIV+) completed the Visual Analogue Effort Scale (VAES), rating their effort from 0-100%...
March 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28327462/neurocognitive-dysfunction-in-hiv-infected-youth-investigating-the-relationship-with-immune-activation
#14
Allison Ross Eckard, Julia C Rosebush, Mary Ann O'Riordan, Chanda C Graves, Ashley Alexander, Anita K Grover, S Thera Lee, Jakob G Habib, Joshua H Ruff, Ann Chahroudi, Grace A McComsey
BACKGROUND: HIV-infected individuals are at increased risk of neurocognitive impairment compared to the general population. Studies suggest that, despite combination antiretroviral therapy (cART), HIV infection causes immune activation which results in neural damage; however, few data exist in HIV-infected youth. METHODS: HIV-infected youth 8-26 years old on cART with virologic suppression were prospectively enrolled along with healthy controls. Neurocognitive performance was assessed by age-appropriate Wechsler Intelligence Scales...
March 22, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28324240/neurocognitive-profiles-in-msud-school-age-patients
#15
Juliette Bouchereau, Julie Leduc-Leballeur, Samia Pichard, Apolline Imbard, Jean-François Benoist, Marie-Thérèse Abi Warde, Jean-Baptiste Arnoux, Valérie Barbier, Anaïs Brassier, Pierre Broué, Aline Cano, Brigitte Chabrol, Gilles Damon, Claire Gay, Isabelle Guillain, Florence Habarou, Delphine Lamireau, Chris Ottolenghi, Laetitia Paermentier, Frédérique Sabourdy, Guy Touati, Hélène Ogier de Baulny, Pascale de Lonlay, Manuel Schiff
Maple syrup urine disease (MSUD), an inborn error of amino acids catabolism is characterized by accumulation of branched chain amino acids (BCAAs) leucine, isoleucine, valine and their corresponding alpha-ketoacids. Impact on the cognitive development has been reported historically, with developmental delays of varying degree. Currently, earlier diagnosis and improved management allow a better neurodevelopment, without requirement of special education. However, specific impairments can be observed, and so far, results of detailed neurocognitive assessments are not available...
March 21, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28322777/preeclampsia-and-cognitive-impairment-later-in-life
#16
Julie A Fields, Vesna D Garovic, Michelle M Mielke, Kejal Kantarci, Muthuvel Jayachandran, Wendy M White, Alissa M Butts, Jonathan Graff-Radford, Brian D Lahr, Kent R Bailey, Virginia M Miller
BACKGROUND: Hypertension is a risk factor for cerebrovascular disease and cognitive impairment. Women who suffer hypertensive episodes during pregnancy report variable neurocognitive changes within the first decade following the affected pregnancy. However, long-term follow-up of these women into their post-menopausal years has not been conducted. OBJECTIVE: The aim of this study was to examine whether women with a history of preeclampsia were at increased risk of cognitive decline 35-40 years after the affected pregnancy...
March 17, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28321696/accelerated-and-accentuated-neurocognitive-aging-in-hiv-infection
#17
David P Sheppard, Jennifer E Iudicello, Erin E Morgan, Rujvi Kamat, Lindsay R Clark, Gunes Avci, Mark W Bondi, Steven Paul Woods
There is debate as to whether the neurocognitive changes associated with HIV infection represent an acceleration of the typical aging process or more simply reflect a greater accentuated risk for age-related declines. We aimed to determine whether accelerated neurocognitive aging is observable in a sample of older HIV-infected individuals compared to age-matched seronegatives and older old (i.e., aged ≥65) seronegative adults. Participants in a cross-sectional design included 48 HIV-seronegative (O-) and 40 HIV-positive (O+) participants between the ages of 50-65 (mean ages = 55 and 56, respectively) and 40 HIV-seronegative participants aged ≥65 (OO-; mean age = 74) who were comparable for other demographics...
March 20, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28320473/which-neural-mechanisms-mediate-the-effects-of-a-parenting-intervention-program-on-parenting-behavior-design-of-a-randomized-controlled-trial
#18
Laura Kolijn, Saskia Euser, Bianca G van den Bulk, Renske Huffmeijer, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
BACKGROUND: The Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD) has proven effective in increasing parental sensitivity. However, the mechanisms involved are largely unknown. In a randomized controlled trial we examine parental neurocognitive factors that may mediate the intervention effects on parenting behavior. Our aims are to (1) examine whether the intervention influences parents' neural processing of children's emotional expressions and the neural precursors of response inhibition and to (2) test whether neural changes mediate intervention effects on parenting behavior...
March 21, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28319690/depression-and-executive-functioning-deficits-predict-poor-occupational-functioning-in-a-large-longitudinal-sample-with-bipolar-disorder
#19
Lisa A O'Donnell, Patricia J Deldin, Andrew Grogan-Kaylor, Melvin G McInnis, Jenna Weintraub, Kelly A Ryan, Joseph A Himle
BACKGROUND: Bipolar Disorder (BD) is characterized by impairments in psychosocial functioning with occupational disability being one of the most significant. Depression and neurocognitive deficits are features of BD most commonly associated with poor occupational functioning (OF). Few studies have examined these features over an extended period of time focusing on distinct aspects of work functioning. METHODS: This longitudinal study included 273 adults with bipolar I disorder (N=173), bipolar II disorder (N=69), and bipolar not otherwise specified (N=31)...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319548/tanshinone-iia-attenuates-sevoflurane-neurotoxicity-in-neonatal-mice
#20
Yimeng Xia, Heng Xu, Chenfei Jia, Xiaodong Hu, Yu Kang, Xiaoxuan Yang, Qingsheng Xue, Guorong Tao, Buwei Yu
BACKGROUND: Sevoflurane is the most widely used inhalational anesthetic in pediatric medicine. Despite this, sevoflurane has been reported to exert potentially neurotoxic effects on the developing brain. Clinical interventions and treatments for these effects are limited. Tanshinone IIA (Tan IIA), extracted from Salvia miltiorrhiza (Danshen), has been documented to alleviate cognitive decline in traditional applications. Therefore, we hypothesized that preadministration of Tan IIA may attenuate sevoflurane-induced neurotoxicity, suggesting that Tan IIA is a new and promising drug capable of counteracting the effects of cognitive dysfunction produced by general anesthetics...
April 2017: Anesthesia and Analgesia
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