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multiple sclerosis risk factors

Roberta Lanzillo, Luca Prosperini, Claudio Gasperini, Marcello Moccia, Roberta Fantozzi, Carla Tortorella, Viviana Nociti, Pietro Annovazzi, Paola Cavalla, Marta Radaelli, Simona Malucchi, Valentina Torri Clerici, Laura Boffa, Fabio Buttari, Paolo Ragonese, Giorgia Teresa Maniscalco, Massimiliano Di Filippo, Maria Chiara Buscarinu, Federica Pinardi, Antonio Gallo, Giancarlo Coghe, Ilaria Pesci, Alice Laroni, Alberto Gajofatto, Massimiliano Calabrese, Valentina Tomassini, Eleonora Cocco, Claudio Solaro
In this independent, multicenter, retrospective study, we investigated the short-term persistence to treatment with first-line self-injectable or oral disease-modifying treatments (DMTs) in patients with relapsing-remitting multiple sclerosis. Data of patients regularly attending 21 Italian MS Centres who started a self-injectable or an oral DMT in 2015 were collected to: (1) estimate the proportion of patients discontinuing the treatment; (3) explore reasons for discontinuation; (3) identify baseline predictors of treatment discontinuation over a follow-up period of 12 months...
March 16, 2018: Journal of Neurology
P Heydarpour, A Manouchehrinia, O Beiki, S E Mousavi, A Abdolalizadeh, M Moradi -Lakeh, M A Sahraian
OBJECTIVES: Multiple sclerosis (MS) is a chronic demyelinating disorder affecting young adults. Environmental factors and lifestyle behaviors are pivotal in MS pathophysiology. Smoking has been considered as an important risk factor in MS. Various recent studies have been conducted to measure the role of smoking on worsening disability in patients with MS, thus we intended to systematically assess effect of smoking on evolution of disability in this study. MATERIALS & METHODS: We queried MEDLINE, EMBASE and Cochrane Library with following keywords "Multiple Sclerosis, Smoking, Tobacco Use, Disability" on December 1st 2016...
March 15, 2018: Acta Neurologica Scandinavica
Jörn Nielsen, Jochen Saliger, Christian Montag, Sebastian Markett, Charlotte Nöhring, Hans Karbe
No abstract text is available yet for this article.
March 13, 2018: Psychotherapy and Psychosomatics
Simona Perga, Serena Martire, Francesca Montarolo, Ilaria Giordani, Michela Spadaro, Gabriele Bono, Stefania Corvisieri, Ilaria Messuti, Giancarlo Panzica, Fabio Orlandi, Antonio Bertolotto
Autoimmune diseases are a diverse group of chronic disorders and affect a multitude of organs and systems. However, the existence of common pathophysiological mechanisms is hypothesized and reports of shared risk are emerging as well. In this regard, patients with multiple sclerosis (MS) have been shown to have an increased susceptibility to develop chronic autoimmune thyroid diseases, in particular Hashimoto's thyroiditis (HT), suggesting an autoimmune predisposition. However, studies comparing such different pathologies of autoimmune origin are still missing till date...
2018: Frontiers in Immunology
L Monge Galindo, A L Martínez de Morentín, V Pueyo Royo, J P García Iñiguez, S Sánchez Marco, J López-Pisón, J L Peña-Segura
INTRODUCTION AND OBJECTIVE: In this article, we present our experience on optic neuritis (ON) and provide a diagnostic/therapeutic protocol, intended to rule out other aetiologies (particularly infection), and a fact sheet for parents. MATERIAL AND METHODS: We conducted a descriptive, retrospective study of patients with ON over a 27-year period (1990-2017). A review of the available scientific evidence was performed in order to draft the protocol and fact sheet...
March 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Marije J D Huitema, Geert J Schenk
PURPOSE OF REVIEW: The proportion to which genetic and environmental factors contribute to the etiology of multiple sclerosis (MS) is still incompletely understood. An interesting association between MS etiology and obesity has recently been shown although the mechanisms underlying this association are still unknown. We propose deregulated gut microbiota and increased leptin levels as possible mechanisms underlying MS etiology in obese individuals. RECENT FINDINGS: Alterations in the human gut microbiota and leptin levels have recently been established as immune modulators in both MS patients and obese individuals...
March 10, 2018: Current Neurology and Neuroscience Reports
Øivind Torkildsen, Trygve Holmøy, Kjell-Morten Myhr
Several reports indicate increased disease activity in patients with multiple sclerosis (MS) undergoing assisted reproductive techniques (ART), in the form of gonadtopin releasing hormone (GnRH) agonists. Other forms of ART treatments, like gonadotropin-treatment, have therefore been considered a safer option for MS-patients. We present a patient who despite being completely clinically and radiologically stable for eight years during disease modifying therapy experienced a nearly fulminant disease course almost immediately after starting gonadotropin-treatment, indicating that this form of follicle stimulating treatment could also be a major risk factor for MS disease activity...
March 6, 2018: Multiple Sclerosis and related Disorders
Raed Alroughani, Alexey Boyko
BACKGROUND: Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are increasing globally. No disease-modifying therapy are approved for MS pediatric population. Hence, we aim to review the literature on POMS to guide treating physicians on the current understanding of diagnosis and management of pediatric MS. METHODS: The authors performed a literature search and reviewed the current understanding on risk factors and disease parameters in order to discuss the challenges in assessing and implementing diagnosis and therapy in clinical practice...
March 9, 2018: BMC Neurology
Jared M Newman, Assem A Sultan, Anton Khlopas, Nipun Sodhi, Mhamad Faour, Nicolas S Piuzzi, Carlos A Higuera, Michael A Mont
Due to the paucity of evidence, this study was conducted to evaluate: (1) unique characteristics of multiple sclerosis (MS) patients and (2) short-term clinical outcomes, of primary total knee arthroplasty (TKA) in patients with MS (MS-TKA) compared with matched non-MS patients. MS patients who underwent TKA were identified using the Nationwide Inpatient Sample (NIS) database. The study sample consisted of 10,884 patients with MS and 56,45,227 control cohort. Various patient factors were compared. To control for potential confounders, with the use of propensity scores, MS-TKA patients were matched (1:3) to non-MS-TKA patients and regression analyses were performed to compare perioperative complications, length of stay (LOS), and discharge dispositions...
March 7, 2018: Journal of Knee Surgery
Amit Katiyar, Sujata Sharma, Tej P Singh, Punit Kaur
Women with endometriosis (EMS) appear to be at a higher risk of developing other autoimmune diseases predominantly multiple sclerosis (MS). Though EMS and MS are evidently diverse in their phenotype, they are linked by a common autoimmune condition or immunodeficiency which could play a role in the expansion of endometriosis and possibly increase the risk of developing MS in women with EMS. However, the common molecular links connecting EMS with MS are still unclear. We conducted a meta-analysis of microarray experiments focused on EMS and MS with their respective controls...
2018: Frontiers in Genetics
Soohyun Kim, Lawrence Chang, Bianca Weinstock-Guttman, Sirin Gandhi, Dejan Jakimovski, Ellen Carl, Robert Zivadinov, Murali Ramanathan
OBJECTIVES: To investigate the factors associated with complementary and alternative medicine (CAM) usage by multiple sclerosis (MS) patients. Design, Setting/Location: Single-center, prospective clinical study at an academic MS center in the northeastern United States. METHODS: This study included CAM data from 524 MS patients and 304 healthy controls (HC) enrolled in a prospective study of clinical, neuroimaging, and environmental risk factors in MS at an academic MS Center...
March 2, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ryohei Ohtani, Masahiro Mori, Tomohiko Uchida, Akiyuki Uzawa, Hiroki Masuda, Jia Liu, Satoshi Kuwabara
Background: Lymphopenia is a well-known adverse event of fingolimod, a disease-modifying drug for multiple sclerosis (MS). Objectives: The objective of this paper is to investigate risk factors for predicting fingolimod-induced lymphopenia in MS by frequent hematological monitoring. Methods: We retrospectively reviewed data of fingolimod-treated MS patients. Data assessed were sex, age, disease duration, medication history, body mass index, all attacks, Kurtzke's Expanded Disability Status Scale score, and absolute lymphocyte count (ALC) within two days before initiating fingolimod (baseline), on the day after first administration (day 2), and at least every other month after initiating fingolimod therapy...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Annette Langer-Gould, Robyn Lucas, Anny H Xiang, Lie H Chen, Jun Wu, Edlin Gonzalez, Samantha Haraszti, Jessica B Smith, Hong Quach, Lisa F Barcellos
Multiple sclerosis (MS) incidence and serum 25-hydroxyvitamin D (25OHD) levels vary by race/ethnicity. We examined the consistency of beneficial effects of 25OHD and/or sun exposure for MS risk across multiple racial/ethnic groups. We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from the membership of Kaiser Permanente Southern California into the MS Sunshine Study to simultaneously examine sun exposure and 25OHD, accounting for genetic ancestry and other factors...
February 27, 2018: Nutrients
Laura Dennison, Martina Brown, Sarah Kirby, Ian Galea
BACKGROUND: Multiple sclerosis (MS) has a varied and uncertain trajectory. The recent development of analytical processing tools that draw on large longitudinal patient databases facilitates personalised long-term prognosis estimates. This has the potential to improve both shared treatment decision-making and psychological adjustment. However, there is limited research on how people with MS feel about prognosis communication and forecasting. This study investigated the prognosis communication experiences and preferences of people with MS and explored whether clinical, demographic and psychological factors are associated with prognosis information preferences...
2018: PloS One
Nasrin Yazdanpanahi, Masoud Etemadifar, Mohammad-Taghi Kardi, Elahe Shams, Shirin Shahbazi
INTRODUCTION: Multiple sclerosis (MS) is a common neuro-inflammatory disease arising from interplay of multiple genetic and nongenetic factors. The complex etiology of MS highlights the importance of investigation in various populations exposed to different genetic and environmental risk factors and combination of the results of these studies for elucidation of the MS underlying mechanisms and management of this disease. The role of ETS-related gene (ERG) in inflammation and immune response has been suggested by different investigations...
February 28, 2018: Immunological Investigations
Roos M van der Vuurst de Vries, Julia Y Mescheriakova, Tessel F Runia, Theodora A M Siepman, Beatrijs H A Wokke, Johnny P A Samijn, Rogier Q Hintzen
BACKGROUND: Cigarette smoking is a modifiable risk factor that influences the disease course of patients with multiple sclerosis (MS). However, in patients with a clinically isolated syndrome (CIS), there are conflicting results about the association between smoking and the risk of a subsequent MS diagnosis. The aim of this study was to determine the risk of clinically definite MS (CDMS) in smoking and non-smoking patients at time of a first demyelinating event. METHODS: Two hundred and fifty patients, aged 18-50 years, were included in our prospective CIS cohort...
February 20, 2018: Journal of Neurology
Georgina Arrambide, Mar Tintore, Carmen Espejo, Cristina Auger, Mireia Castillo, Jordi Río, Joaquín Castilló, Angela Vidal-Jordana, Ingrid Galán, Carlos Nos, Raquel Mitjana, Patricia Mulero, Andrea de Barros, Breogán Rodríguez-Acevedo, Luciana Midaglia, Jaume Sastre-Garriga, Alex Rovira, Manuel Comabella, Xavier Montalban
The presence of oligoclonal bands in clinically isolated syndromes is an independent risk factor for developing multiple sclerosis and has been largely excluded from the more recent multiple sclerosis diagnostic criteria. Therefore, our objective was to explore the value of oligoclonal bands in the context of the 2010 McDonald criteria, especially in patients fulfilling exclusively dissemination in space at baseline. For this purpose, we selected 566 patients from a clinically isolated syndrome inception cohort who had IgG oligoclonal bands determination and sufficient data on baseline brain MRI to assess dissemination in space and time...
February 16, 2018: Brain: a Journal of Neurology
Hiroshi Mitoma, Mario Manto, Christiane S Hampe
The cerebellum characteristically has the capacity to compensate for and restore lost functions. These compensatory/restorative properties are explained by an abundant synaptic plasticity and the convergence of multimodal central and peripheral signals. In addition, extra-cerebellar structures contribute also to the recovery after a cerebellar injury. Clinically, some patients show remarkable improvement of severe ataxic symptoms associated with trauma, stroke, metabolism, or immune-mediated cerebellar ataxia (IMCA, e...
February 19, 2018: Cerebellum
Azra Zafar, Majed Alabdali, Rizwana Shahid, Danah Aljaafari, Fahd A Al-Khamis, Aishah I Albakr, Saima Nazish, Abdulla A Al-Sulaiman, Alon Abraham
OBJECTIVE: To assess the burden and describe the pattern of neurological disorders requiring admissions in a teaching hospital of Al Khobar. METHODS: This is a retrospective, cross sectional study, carried out in the Neurology Department of King Fahd Hospital of the University from January 2009 to December 2016. Neurological disorders were grouped as ischemic stroke, intracerebral hemorrhage, transient ischemic attack, cerebral venous sinus thrombosis, seizure disorders, central nervous system infection, multiple sclerosis, neuropathies, myopathies, headache, dementia and miscellaneous group...
January 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Clara Matute-Blanch, Luisa M Villar, José C Álvarez-Cermeño, Konrad Rejdak, Evgeniy Evdoshenko, Gleb Makshakov, Vladimir Nazarov, Sergey Lapin, Luciana Midaglia, Angela Vidal-Jordana, Jelena Drulovic, Antonio García-Merino, Antonio J Sánchez-López, Eva Havrdova, Albert Saiz, Sara Llufriu, Roberto Alvarez-Lafuente, Ina Schroeder, Uwe K Zettl, Daniela Galimberti, Lluís Ramió-Torrentà, René Robles, Ester Quintana, Harald Hegen, Florian Deisenhammer, Jordi Río, Mar Tintoré, Alex Sánchez, Xavier Montalban, Manuel Comabella
The prognostic role of cerebrospinal fluid molecular biomarkers determined in early pathogenic stages of multiple sclerosis has yet to be defined. In the present study, we aimed to investigate the prognostic value of chitinase 3 like 1 (CHI3L1), neurofilament light chain, and oligoclonal bands for conversion to clinically isolated syndrome and to multiple sclerosis in 75 patients with radiologically isolated syndrome. Cerebrospinal fluid levels of CHI3L1 and neurofilament light chain were measured by enzyme-linked immunosorbent assay...
February 14, 2018: Brain: a Journal of Neurology
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