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https://www.readbyqxmd.com/read/28318978/the-mitochondrial-dna-polymerase-promotes-elimination-of-paternal-mitochondrial-genomes
#1
Zhongsheng Yu, Patrick H O'Farrell, Nikita Yakubovich, Steven Z DeLuca
Mitochondrial DNA (mtDNA) is typically inherited from only one parent [1-3]. In animals, this is usually the mother. Maternal inheritance is often presented as the passive outcome of the difference in cytoplasmic content of egg and sperm; however, active programs enforce uniparental inheritance at two levels, eliminating paternal mitochondrial genomes or destroying mitochondria delivered to the zygote by the sperm [4-13]. Both levels operate in Drosophila [8, 12, 13]. As sperm formation begins, hundreds of doomed mitochondrial genomes are visualized within the two huge mitochondria of each spermatid...
March 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28317463/expression-of-a-morn-repeat-protein-from-euplotes-octocarinatus-requires-a-1-programmed-ribosomal-frameshifting
#2
Lili Wei, Xuemei Zhao, Ruanlin Wang, Yuejun Fu, Baofeng Chai, Aihua Liang
Analysis of transcriptome revealed that a membrane occupation and recognition nexus (MORN) repeat protein-encoding gene of Euplotes octocarinatus (Eo-morn-9-31) was a candidate for programmed +1 ribosomal frameshifting (+1 PRF). In this study, a dual-luciferase assay was performed to detect its expression. The result showed that the MORN repeat protein (Eo-MORN-9-31) could be produced by the +1 PRF event during the process of translation in yeast and the frameshifting efficiency was about 4-5%. We further confirmed its reality by western blot and mass spectrometry...
March 20, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28306509/the-pten-parkin-axis-at-the-nexus-of-cancer-and-neurodegeneration
#3
Nathan T Ihle, Robert T Abraham
The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson's disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling.
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28299185/recent-advances-in-understanding-the-cellular-roles-of-gsk-3
#4
REVIEW
Kevin W Cormier, James R Woodgett
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control circuits is consummate to its implication in diseases ranging from mood disorders to diabetes to neurodegenerative diseases and cancers. The selectivity and insulation of such a promiscuous kinase from unwanted crosstalk between pathways, while orchestrating a multifaceted response to cellular stimuli, offer key insights into more general mechanisms of cell regulation...
2017: F1000Research
https://www.readbyqxmd.com/read/28296623/medicalizing-the-opioid-epidemic-in-the-u-s-in-the-era-of-health-care-reform
#5
David E Smith
The medicalization of the current opioid epidemic in the era of health care reform and parity, and its possible dismantling, poses many challenges. Between 2002 and 2013, drug overdose rates quadrupled. Parallel to an increase in prescription opioid overdose, heroin overdose deaths are increasing as patients shift to cheaper and more accessible heroin from the prescription opioids which physicians are prescribing less often due to increasing regulatory restrictions, as well as enhanced education and awareness...
March 15, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28295002/-ultrastructural-characteristics-of-gap-junctions-in-human-glial-brain-tumors
#6
E Yu Kirichenko, A F Savchenko, D V Kozachenko, A E Matsionis, A K Logvinov
AIM: to conduct an electron microscopic study of intercellular communication in the samples of gemistocytic astrocytoma, oligodendroglioma, and glioblastoma. MATERIAL AND METHODS: Surgically resected tumor tissue fragments were fixed in 2.5% glutaraldehyde solution, afterfixed in 1% OsO4 solution, dehydrated, and embedded in epoxy resin. Ultrathin sections were examined using a Jem 1011 electron microscope (Jeol, Japan). RESULTS: Solitary and closely spaced gap junctions (GJs) formed by the thin processes that have the ultrastructure of an astroglial processes were identified in the astrocytoma samples...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28291253/mecp2-mediated-epigenetic-silencing-of-mir-137-contributes-to-colorectal-adenoma-carcinoma-sequence-and-tumor-progression-via-relieving-the-suppression-of-c-met
#7
Tao Chen, Shi-Lun Cai, Jian Li, Zhi-Peng Qi, Xu-Quan Li, Le-Chi Ye, Xiao-Feng Xie, Ying-Yong Hou, Li-Qing Yao, Mei-Dong Xu, Ping-Hong Zhou, Jian-Min Xu, Yun-Shi Zhong
The molecular mechanisms underlying colorectal cancer (CRC) development remain elusive. In this study, we examined the miRNA and mRNA expressions in the adenoma-carcinoma sequence (ACS), a critical neoplastic progression in CRC development. We found that miR-137 was down-regulated in all adenoma and carcinoma tissues. Low miR-137 levels were correlated negatively with tumor progression and metastasis. Then we identified the inhibition effect of the miR-137 in CRC development, both in CRC cell lines and mouse models...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286594/locking-it-down-the-privacy-and-security-of-mobile-medication-apps
#8
Kelly Grindrod, Jonathan Boersema, Khrystine Waked, Vivian Smith, Jilan Yang, Catherine Gebotys
OBJECTIVE: To explore the privacy and security of free medication applications (apps) available to Canadian consumers. METHODS: The authors searched the Canadian iTunes store for iOS apps and the Canadian Google Play store for Android apps related to medication use and management. Using an Apple iPad Air 2 and a Google Nexus 7 tablet, 2 reviewers generated a list of apps that met the following inclusion criteria: free, available in English, intended for consumer use and related to medication management...
January 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28284373/reframing-the-food-biodiversity-challenge
#9
REVIEW
Joern Fischer, David J Abson, Arvid Bergsten, Neil French Collier, Ine Dorresteijn, Jan Hanspach, Kristoffer Hylander, Jannik Schultner, Feyera Senbeta
Given the serious limitations of production-oriented frameworks, we offer here a new conceptual framework for how to analyze the nexus of food security and biodiversity conservation. We introduce four archetypes of social-ecological system states corresponding to win-win (e.g., agroecology), win-lose (e.g., intensive agriculture), lose-win (e.g., fortress conservation), and lose-lose (e.g., degraded landscapes) outcomes for food security and biodiversity conservation. Each archetype is shaped by characteristic external drivers, exhibits characteristic internal social-ecological features, and has characteristic feedbacks that maintain it...
March 8, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28283293/linking-energy-sanitation-agriculture-intersectional-resource-management-in-smallholder-households-in-tanzania
#10
Ariane Krause, Vera Susanne Rotter
In order to create sustainable systems for resource management, residues from cooking and ecological sanitation (EcoSan) can be employed in recycling-driven soil fertility management. However, the link between energy, sanitation, and agricultural productivity is often neglected. Hence, the potential self-sufficient nature of many smallholdings in sub-Saharan Africa is underexploited. OBJECTIVE: To compare those cooking and sanitation technologies most commonly used in north-western Tanzania with locally developed alternatives, with respect to (i) resource consumption, (ii) potential to recover resources, and (iii) environmental emissions...
March 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28283125/money-gone-up-in-smoke-the-tobacco-use-and-malnutrition-nexus-in-bangladesh
#11
Muhammad Jami Husain, Mandeep Virk-Baker, Mark Parascandola, Bazlul Haque Khondker, Indu B Ahluwalia
BACKGROUND: The tobacco epidemic in Bangladesh is pervasive. Expenditures on tobacco may reduce money available for food in a country with a high malnutrition rate. OBJECTIVES: The aims of the study are to quantify the opportunity costs of tobacco expenditure in terms of nutrition (ie, food energy) forgone and the potential improvements in the household level food-energy status if the money spent on tobacco were diverted for food consumption. METHOD: We analyzed data from the 2010 Bangladesh Household Income and Expenditure Survey, a nationally representative survey conducted among 12,240 households...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28280285/hyaluronic-acid-and-phospholipid-interactions-useful-for-repaired-articular-cartilage-surfaces-a-mini-review-toward-tribological-surgical-adjuvants
#12
REVIEW
Stanislaw Jung, Aneta Petelska, Piotr Beldowski, Wayne K Augé, Tahlia Casey, Dominik Walczak, Krzysztof Lemke, Adam Gadomski
This mini review is focused on the emerging nexus between the medical device and pharmaceutical industries toward the treatment of damaged articular cartilage. The physical rationale of hyaluronic acid and phospholipid preparations as tribological surgical adjuvants for repaired articular cartilage surfaces is explored, with directions for possible new research which have arisen due to the therapeutic advance of the physiochemical scalpel. Because synovial joint lubrication regimes become dysfunctional at articular cartilage lesion sites as a result of the regional absence of the surface active phospholipid layer and its inability to reform without surgical repair, hyaluronic acid and phospholipid intra-articular injections have yielded inconsistent efficacy outcomes and only short-term therapeutic benefits mostly due to non-tribological effects...
2017: Colloid and Polymer Science
https://www.readbyqxmd.com/read/28274471/the-nexus-criteria-are-insufficient-to-exclude-cervical-spine-fractures-in-older-blunt-trauma-patients
#13
Gabriel Paykin, Gerard O'Reilly, Helen M Ackland, Biswadev Mitra
BACKGROUND AND OBJECTIVE: The National Emergency X-Radiography Utilization Study (NEXUS) criteria are used to assess the need for imaging to evaluate cervical spine integrity after injury. The aim of this study was to assess the sensitivity of the NEXUS criteria in older blunt trauma patients. METHODS: Patients aged 65 years or older presenting between 1st July 2010 and 30th June 2014 and diagnosed with cervical spine fractures were identified from the institutional trauma registry...
February 22, 2017: Injury
https://www.readbyqxmd.com/read/28266316/genomic-copy-number-variation-associated-with-clinical-outcome-in-canine-cutaneous-mast-cell-tumors
#14
Paulo C Jark, Deborah B P Mundin, Marcio de Carvalho, Raquel B Ferioli, Letícia A Anai, Fabio A Marchi, Silvia R Rogatto, Renee Laufer-Amorim, Mirela Tinucci-Costa
Mast cell tumors are the most common malignant cutaneous tumors in dogs. Although there are several prognostic factors involved, the clinical and biological behavior of this type of tumor varies greatly, making the best choice of treatment challenging. Molecular techniques can be used to evaluate a large number of genes involved in the neoplastic process and aid in the selection of candidate genes related to prognostic and predicting factors. Identification of the genes associated with tumor development and progression can be performed through the analysis of numerical and structural changes in DNA isolated from tumor cells by array comparative genomic hybridization (aCGH)...
November 17, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/28262366/quantification-of-the-urban-water-energy-nexus-in-m%C3%A3-xico-city-m%C3%A3-xico-with-an-assessment-of-water-system-related-carbon-emissions
#15
Adrián Moredia Valek, Janez Sušnik, Stelios Grafakos
Global urbanisation will put considerable stress on both water and energy resources. While there is much research at the national and regional levels on the energy implications of water supply (the urban water-energy 'nexus'), there is relatively little at the city scale. This literature is further diminished when attempting to account for the climate impact of urban water systems. A study of the urban water-energy-climate nexus is presented for México City. It is shown that 50% of México City water comes from a local aquifer with a further 30% deriving from energy-intensive surface sources which are pumped over considerable topography...
March 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28258692/lag3-cd223-as-a-cancer-immunotherapy-target
#16
REVIEW
Lawrence P Andrews, Ariel E Marciscano, Charles G Drake, Dario A A Vignali
Despite the impressive impact of CTLA4 and PD1-PDL1-targeted cancer immunotherapy, a large proportion of patients with many tumor types fail to respond. Consequently, the focus has shifted to targeting alternative inhibitory receptors (IRs) and suppressive mechanisms within the tumor microenvironment. Lymphocyte activation gene-3 (LAG3) (CD223) is the third IR to be targeted in the clinic, consequently garnering considerable interest and scrutiny. LAG3 upregulation is required to control overt activation and prevent the onset of autoimmunity...
March 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28256896/the-nexus-between-patient-centered-care-and-complementary-medicine-allies-in-the-era-of-chronic-disease
#17
Hope Foley, Amie Steel
Complementary medicine (CM) holds an established place of value for health care consumers around the world. Consumers seek CM specifically for the type of clinical care provided by CM practitioners, which is perceived as holistic and individualized. The holistic approach of CM has been described as patient-centered and there are indeed many parallels between the philosophy of holism and the paradigm of patient-centered care (PCC). In light of the contemporary movement toward PCC as a means of improving health care delivery, it is worth exploring CM as a potential existing resource of PCC...
March 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28256314/intra-eu-agricultural-trade-virtual-water-flows-and-policy-implications
#18
M Antonelli, S Tamea, H Yang
The development of approaches to tackle the European Union (EU) water-related challenges and shift towards sustainable water management and use is one of the main objectives of Horizon 2020, the EU strategy to lead a smart, sustainable and inclusive growth. The EU is an increasingly water challenged area and is a major agricultural trader. As agricultural trade entails an exchange of water embodied in goods as a factor of production, this study investigates the region's water-food-trade nexus by analysing intra-regional virtual water trade (VWT) in agricultural products...
February 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28254092/extending-gelj-for-interoperability-filling-the-gap-in-the-bioinformatics-resources-for-population-genetics-analysis-with-dominant-markers
#19
César Domínguez, Jónathan Heras, Eloy Mata, Vico Pascual, Maria Soledad Vázquez-Garcidueñas, Gerardo Vázquez-Marrufo
BACKGROUND AND OBJECTIVE: The manual transformation of DNA fingerprints of dominant markers into the input of tools for population genetics analysis is a time-consuming and error-prone task; especially when the researcher deals with a large number of samples. In addition, when the researcher needs to use several tools for population genetics analysis, the situation worsens due to the incompatibility of data-formats across tools. The goal of this work consists in automating, from banding patterns of gel images, the input-generation for the great diversity of tools devoted to population genetics analysis...
March 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28251538/sectoral-output-energy-use-and-co2-emission-in-middle-income-countries
#20
Kazi Sohag, Md Al Mamun, Gazi Salah Uddin, Ali M Ahmed
Middle-income countries are currently undergoing massive structural changes towards more industrialized economies. In this paper, we carefully examine the impact of these transformations on the environmental quality of middle-income countries. Specifically, we examine the role of sector value addition to GDP on CO2 emission nexus for middle-income economies controlling for the effects of population growth, energy use, and trade openness. Using recently developed panel methods that consider cross-sectional dependence and allow for heterogeneous slope coefficients, we show that energy use and growth of industrial and service sectors positively explain CO2 emissions in middle-income economies...
March 1, 2017: Environmental Science and Pollution Research International
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