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https://www.readbyqxmd.com/read/29232770/review-article-nexus-criteria-to-rule-out-cervical-spine-injury-among-older-patients-a-systematic-review
#1
REVIEW
Gabriel Paykin, Gerard O'Reilly, Helen Ackland, Biswadev Mitra
The National Emergency X-Radiography Utilization Study (NEXUS) criteria were derived from a heterogeneous group of adult blunt trauma patients, with the outcome measure assessed most commonly using plain X-ray radiographs. Recent observations have suggested inadequacy of these criteria for excluding injury in population subgroups such as the elderly. The aim of this systematic review was to determine the sensitivity of the NEXUS criteria in excluding cervical spine injury among older patients aged ≥65 years...
December 12, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29224082/generating-electric-current-by-bioartificial-photosynthesis
#2
Babu Halan, Jenny Tschörtner, Andreas Schmid
Abundant solar energy can be a sustainable source of energy. This chapter highlights recent advancements, challenges, and future scenarios in bioartificial photosynthesis, which is a new subset of bioelectrochemical systems (BESs) and technologies. BES technologies exploit the catalytic interactions between biological moieties and electrodes. At the nexus of BES and photovoltaics, this review focuses on light-harvesting technologies based on bioartificial photosynthesis. Such technologies are promising because electrical energy is generated from sunlight and water without the need for additional organic feedstock...
December 10, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29215711/triage-tools-for-detecting-cervical-spine-injury-in-pediatric-trauma-patients
#3
REVIEW
Annelie Slaar, M M Fockens, Junfeng Wang, Mario Maas, David J Wilson, J Carel Goslings, Niels Wl Schep, Rick R van Rijn
BACKGROUND: Pediatric cervical spine injury (CSI) after blunt trauma is rare. Nonetheless, missing these injuries can have severe consequences. To prevent the overuse of radiographic imaging, two clinical decision tools have been developed: The National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian C-spine Rule (CCR). Both tools are proven to be accurate in deciding whether or not diagnostic imaging is needed in adults presenting for blunt trauma screening at the emergency department...
December 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29213159/nexus-between-demographic-change-and-elderly-care-need-in-the-gulf-cooperation-council-gcc-countries-some-policy-implications
#4
Hafiz T A Khan, Shereen Hussein, John Deane
Population ageing is a phenomenon affecting the whole world. The countries that make up the Gulf Cooperation Council (GCC) are no exception but transitions in population ageing are still in the early stages of the process. With current demographic dividends experienced by the GCC and the rest of the Middle-East, the pace of population ageing will be faster than that experienced by many European countries. The purpose of this paper is to explore the population ageing experience of different GCC countries while situating this within a context of social policies that still at the very early stages of acknowledging such change...
2017: Ageing International
https://www.readbyqxmd.com/read/29211822/insights-from-resolving-protein-dna-interactions-at-near-base-pair-resolution
#5
Bryan J Venters
One of the central goals in molecular biology is to understand how cell-type-specific expression patterns arise through selective recruitment of RNA polymerase II (Pol II) to a subset of gene promoters. Pol II needs to be recruited to a precise genomic position at the proper time to produce messenger RNA from a DNA template. Ostensibly, transcription is a relatively simple cellular process; yet, experimentally measuring and then understanding the combinatorial possibilities of transcriptional regulators remain a daunting task...
December 2, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29195049/a-solid-state-conceptualization-of-information-transfer-from-gene-to-message-to-protein
#6
Masato Kato, Steven L McKnight
In this review, we describe speculative ideas and early stage research concerning the flow of genetic information from the nuclear residence of genes to the disparate, cytoplasmic sites of protein synthesis. We propose that this process of information transfer is meticulously guided by transient structures formed from protein segments of low sequence complexity/intrinsic disorder. These low complexity domains are ubiquitously associated with regulatory proteins that control gene expression and RNA biogenesis, but they are also found in the central channel of nuclear pores, the nexus points of intermediate filament assembly, and the locations of action of other well-studied cellular proteins and pathways...
December 1, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29191571/distinguish-self-and-hetero-perceived-stress-through-behavioral-imaging-and-physiological-features
#7
Michel Spodenkiewicz, Jonathan Aigrain, Nadège Bourvis, Séverine Dubuisson, Mohamed Chetouani, David Cohen
Stress reactivity is a complex phenomenon associated to multiple and multimodal expressions. Response to stressors has an obvious survival function and may be seen as an internal regulation to adapt to threat or danger. The intensity of this internal response can be assessed as the self-perception of the stress response. In species with social organization, this response also serves a communicative function, so-called hetero-perception. Our study presents multimodal stress detection assessment - a new methodology combining behavioral imaging and physiological monitoring for analyzing stress from these two perspectives...
November 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29191370/linc-complexes-and-nuclear-positioning
#8
REVIEW
Yin Loon Lee, Brian Burke
One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through dermal differentiation in nematodes, to muscle and neuronal development in vertebrates. Each of these processes involves oftentimes dramatic relocation of the nucleus within the cell. During the last decade it has become apparent that the nuclear periphery represents a nexus of cytoskeletal interactions that are involved not only in nuclear movement but also in the distribution and dissemination of mechanical forces throughout the cell...
November 27, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29188440/minimizing-irrigation-water-demand-an-evaluation-of-shifting-planting-dates-in-sri-lanka
#9
Ashley Rivera, Thushara Gunda, George M Hornberger
Climate change coupled with increasing demands for water necessitates an improved understanding of the water-food nexus at a scale local enough to inform farmer adaptations. Such assessments are particularly important for nations with significant small-scale farming and high spatial variability in climate, such as Sri Lanka. By comparing historical patterns of irrigation water requirements (IWRs) to rice planting records, we estimate that shifting rice planting dates to earlier in the season could yield water savings of up to 6%...
November 29, 2017: Ambio
https://www.readbyqxmd.com/read/29187623/skill-not-athleticism-predicts-individual-variation-in-match-performance-of-soccer-players
#10
REVIEW
Robbie S Wilson, Gwendolyn K David, Sean C Murphy, Michael J Angilletta, Amanda C Niehaus, Andrew H Hunter, Michelle D Smith
Just as evolutionary biologists endeavour to link phenotypes to fitness, sport scientists try to identify traits that determine athlete success. Both disciplines would benefit from collaboration, and to illustrate this, we used an analytical approach common to evolutionary biology to isolate the phenotypes that promote success in soccer, a complex activity of humans played in nearly every modern society. Using path analysis, we quantified the relationships among morphology, balance, skill, athleticism and performance of soccer players...
December 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29187113/immune-system-in-single-ventricle-patients-a-complex-nexus
#11
S Ram Kumar
No abstract text is available yet for this article.
November 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29186975/mammalian-sulfur-amino-acid-metabolism-a-nexus-between-redox-regulation-nutrition-epigenetics-and-detoxification
#12
María Angeles Pajares, Dolores Pérez-Sala
SIGNIFICANCE: Transsulfuration allows conversion of methionine into cysteine using homocysteine as an intermediate. This pathway produces S-adenosylmethionine, a key metabolite for cell function, and provides 50% of the cysteine needed for hepatic glutathione synthesis. The route requires the intake of essential nutrients (e.g. methionine, vitamins) and is regulated by their availability. Transsulfuration presents multiple interconnections with epigenetics, ATP and glutathione synthesis, polyol and pentose phosphate pathways and detoxification that rely mostly in the exchange of substrates or products...
November 30, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29186831/integrated-management-of-residential-indoor-air-quality-a-call-for-stakeholders-in-a-changing-climate
#13
REVIEW
Marie-Eve Levasseur, Patrick Poulin, Céline Campagna, Jean-Marc Leclerc
A paradigm change in the management of environmental health issues has been observed in recent years: instead of managing specific risks individually, a holistic vision of environmental problems would assure sustainable solutions. However, concrete actions that could help translate these recommendations into interventions are lacking. This review presents the relevance of using an integrated indoor air quality management approach to ensure occupant health and comfort. At the nexus of three basic concepts (reducing contaminants at the source, improving ventilation, and, when relevant, purifying the indoor air), this approach can help maintain and improve indoor air quality and limit exposure to several contaminants...
November 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29173460/conceptualising-forensic-science-and-forensic-reconstruction-part-ii-the-critical-interaction-between-research-policy-law-and-practice
#14
R M Morgan
This paper builds on the FoRTE conceptual model presented in part I to address the forms of knowledge that are integral to the four components of the model. Articulating the different forms of knowledge within effective forensic reconstructions is valuable. It enables a nuanced approach to the development and use of evidence bases to underpin decision-making at every stage of a forensic reconstruction by enabling transparency in the reporting of inferences. It also enables appropriate methods to be developed to ensure quality and validity...
November 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29173165/running-head-chalcones-as-immunomodulatory-agents-exploring-promising-immunomodulatory-potential-of-natural-and-synthetic-1-3-diphenyl-2-propen-1-one-analogs-a-review-of-mechanistic-insight
#15
Muhammad Hassan Safdar, Humna Hasan, Sajal Afzal, Zahid Hussain
BACKGROUND: The immune system is an intricate and coordinated nexus serving as a natural defense to preclude internal and external pathogenic insults. The deregulation in the natural balance of immunological functions, as a consequence of either over expression or under expression of immune cells may cause development of numerous immune disorders. Chalcone moieties (1,3-diphenyl-2-propen-1-one) have been well-documented as ideal lead compounds or precursors to design wide range of pharmacologically active agents to down-regulate various immune disorders...
November 23, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29162698/ideals-practices-and-future-prospects-of-stakeholder-involvement-in-sustainability-science
#16
Jahel Mielke, Hannah Vermaßen, Saskia Ellenbeck
This paper evaluates current stakeholder involvement (SI) practices in science through a web-based survey among scholars and researchers engaged in sustainability or transition research. It substantiates previous conceptual work with evidence from practice by building on four ideal types of SI in science. The results give an interesting overview of the varied landscape of SI in sustainability science, ranging from the kinds of topics scientists work on with stakeholders, over scientific trade-offs that arise in the field, to improvements scientists wish for...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29161539/home-is-where-the-future-is-the-brightfocus-foundation-consensus-panel-on-dementia-care
#17
Quincy M Samus, Constantine G Lyketsos, Betty Smith Black, Diane Bovenkamp, Michael Buckley, Christopher Callahan, Karen Davis, Laura N Gitlin, Nancy Hodgson, Deirdre Johnston, Helen C Kales, Michele Karel, John Jay Kenney, Shari M Ling, Maï Panchal, Melissa Reuland, Amber Willink
INTRODUCTION: A national consensus panel was convened to develop recommendations on future directions for home-based dementia care (HBDC). METHODS: The panel summarized advantages and challenges of shifting to HBDC as the nexus of care and developed consensus-based recommendations. RESULTS: The panel developed five core recommendations: (1) HBDC should be considered the nexus of new dementia models, from diagnosis to end of life in dementia; (2) new payment models are needed to support HBDC and reward integration of care; (3) a diverse new workforce that spans the care continuum should be prepared urgently; (4) new technologies to promote communication, monitoring/safety, and symptoms management must be tested, integrated, and deployed; and (5) targeted dissemination efforts for HBDC must be employed...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29154822/mef2-and-the-skeletal-muscle-differentiation-program
#18
REVIEW
Michael V Taylor, Simon M Hughes
Mef2 is a conserved and significant transcription factor in the control of muscle gene expression. In cell culture Mef2 synergises with MyoD-family members in the activation of gene expression and in the conversion of fibroblasts into myoblasts. Amongst its in vivo roles, Mef2 is required for both Drosophila muscle development and mammalian muscle regeneration. Mef2 has functions in other cell-types too, but this review focuses on skeletal muscle and surveys key findings on Mef2 from its discovery, shortly after that of MyoD, up to the present day...
November 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29147624/high-cxc-chemokine-receptor-1-level-represents-an-independent-negative-prognosticator-in-non-metastatic-clear-cell-renal-cell-carcinoma-patients
#19
Yu Zhu, Zheng Liu, Yiwei Wang, Hangcheng Fu, Zewei Wang, Huyang Xie, Junyu Zhang, Gaoxiang Li, Bo Dai, Dingwei Ye, Jiejie Xu
CXC chemokine receptor 1 (CXCR1) signaling has been shown as an essential molecular nexus regarding cancer cell proliferation, tumor inflammation, and angiogenesis in clear cell renal cell carcinoma (ccRCC). The aim of this study was to investigate the prognostic significance of CXCR1 in patients with non-metastatic ccRCC. Data from 446 consecutive non-metastatic ccRCC patients, operated between 2003 and 2008 at a single institution, were evaluated retrospectively. The cohort was split into a training set (n = 223) and a validation set (n = 223)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29141214/partitioning-of-one-carbon-units-in-folate-and-methionine-metabolism-is-essential-for-neural-tube-closure
#20
Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S Gross, Andrew J Copp, Nicholas D E Greene
Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore, represents a key nexus in partitioning one-carbon units between FOCM functional outputs. Methionine cycle inhibitors prevent neural tube closure in mouse embryos. Similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes NTDs in glycine decarboxylase (Gldc)-deficient embryos...
November 14, 2017: Cell Reports
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