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https://www.readbyqxmd.com/read/28429478/the-nexus-between-periodontics-and-oral-pathology
#1
REVIEW
Alison M Rich, Benedict Seo, Venkata Parachuru, Haizal M Hussaini
A wide variety of lesions may arise from the oral mucosa, fibrous connective tissue, bone and cementum of the periodontium. The commonest pathology occurs as a result of bacterial infection and is very well known to dentists and periodontists, but rarer conditions present as gingival pathology. The pathogenesis of these conditions ranges from genetic to traumatic to immunological to neoplastic, and includes benign, malignant and metastatic lesions. This paper outlines some of these conditions and describes how the periodontist and oral pathologist can work together using a framework, and how with careful consideration of the clinical features and the use of appropriate special tests, including obtaining an adequate tissue specimen, a timely and accurate diagnosis can be obtained...
June 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28428164/zika-in-twitter-temporal-variations-of-locations-actors-and-concepts
#2
Anthony Stefanidis, Emily Vraga, Georgios Lamprianidis, Jacek Radzikowski, Paul L Delamater, Kathryn H Jacobsen, Dieter Pfoser, Arie Croitoru, Andrew Crooks
BACKGROUND: The recent Zika outbreak witnessed the disease evolving from a regional health concern to a global epidemic. During this process, different communities across the globe became involved in Twitter, discussing the disease and key issues associated with it. This paper presents a study of this discussion in Twitter, at the nexus of location, actors, and concepts. OBJECTIVE: Our objective in this study was to demonstrate the significance of 3 types of events: location related, actor related, and concept related, for understanding how a public health emergency of international concern plays out in social media, and Twitter in particular...
April 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28427795/reappraisal-to-the-study-of-4e-bp1-as-an-mtor-substrate-a-normative-critique
#3
REVIEW
Asiya Batool, Sabreena Aashaq, Khurshid Iqbal Andrabi
mTOR-4E-BP1 axis is regarded as the best oncogenic circuitry impinging on translational control whereby mTORC1 dictates post-translational regulation of 4E-BP1. This review provides new insights into the molecular network of signalling pathways highlighting the recent explosion of studies in respect to the deviant behaviour of 4E-BP1 towards mTORC1. Despite the striking conservation of mTOR nexus, the eccentric phosphorylation dynamics of 4E-BP1 negate the apparent linear architecture of mTORC1 attesting the importance of other kinases that may evoke cross-talks with the conventional frame, most of which are enlisted in the manuscript...
April 8, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28424212/pdgf-receptor-%C3%AE-uses-akt-mtorc1-signaling-node-to-promote-high-glucose-induced-renal-proximal-tubular-cell-collagen-i-%C3%AE-2-expression
#4
Falguni Das, Nandini Ghosh-Choudhury, Balachandar Venkatesan, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Increased expression of PDGF receptor-β (PDGFRβ) has been shown in the diabetic renal proximal tubules. The core molecular network used by high glucose to induce proximal tubular epithelial cell collagen I (α2) expression is poorly understood. We hypothesized that activation of PDGFRβ by high glucose increases collagen I (α2) production via Akt/mTORC1 signaling pathway in proximal tubular epithelial cells. Using biochemical and molecular biological techniques, we investigated this hypothesis. We show that high glucose increases activating phosphorylation of the PDGFRβ, resulting in the phosphorylation of the phosphatidylinositol 3 kinase...
April 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28417581/radiopacity-of-resin-cements-using-digital-radiography
#5
Sherif Hosney, Hanan K Abouelseoud, Omar El-Mowafy
STATEMENT OF PROBLEM: Monitoring performance of glass-ceramic based indirect restorations using radiographic imaging might be difficult due to their low radiopacity. Therefore, materials used for their cementation must possess adequate radiopacity. PURPOSE: This study determined radiopacity of a group of resin-cements used for adhesive-cementation of glass-ceramic-based restorations using digital radiography. METHODS: Two specimens were prepared from a group of resin cements (VariolinkII-opaque, VariolinkII-opaque (base), VariolinkII-Transparent, VariolinkII-Transparent (base), Nexus, RelyX Unicem, RelyX ultimate, Duolink, Monocem and Resinomer) and longitudinal sections of same thickness were obtained from molar and premolar...
April 18, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28414588/prehospital-predictors-of-traumatic-spinal-cord-injury-in-victoria-australia
#6
Alaa O Oteir, Karen Smith, Johannes Stoelwinder, James W Middleton, Shelley Cox, Lisa N Sharwood, Paul A Jennings
OBJECTIVES: To identify the predictors of traumatic spinal cord injury (TSCI) and describe the differences between confirmed and potential TSCI cases in the prehospital setting. METHODS: A retrospective cohort study including all adult patients over a six-year period (2007-12) with potential TSCI who were attended and transported by Ambulance Victoria (AV). We extracted potential TSCI cases from the AV data warehouse and linked with the Victorian State Trauma Registry to compare with final hospital diagnosis...
April 17, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28412980/arctic-systems-in-the-quaternary-ecological-collision-faunal-mosaics-and-the-consequences-of-a-wobbling-climate
#7
E P Hoberg, J A Cook, S J Agosta, W Boeger, K E Galbreath, S Laaksonen, S J Kutz, D R Brooks
Climate oscillations and episodic processes interact with evolution, ecology and biogeography to determine the structure and complex mosaic that is the biosphere. Parasites and parasite-host assemblages are key components in a general explanatory paradigm for global biodiversity. We explore faunal assembly in the context of Quaternary time frames of the past 2.6 million years, a period dominated by episodic shifts in climate. Climate drivers cross a continuum from geological to contemporary timescales and serve to determine the structure and distribution of complex biotas...
April 17, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28412622/population-production-pollution-nexus-based-air-pollution-management-model-for-alleviating-the-atmospheric-crisis-in-beijing-china
#8
X T Zeng, Y F Tong, L Cui, X M Kong, Y N Sheng, L Chen, Y P Li
In recent years, increscent emissions in the city of Beijing due to expanded population, accelerated industrialization and inter-regional pollutant transportation have led to hazardous atmospheric pollution issues. Although a number of anthropogenic control measures have been put into use, frequent/severe haze events have still challenged regional governments. In this study, a hybrid population-production-pollution nexus model (PPP) is proposed for air pollution management and air quality planning (AMP) with the aim to coordinate human activities and environmental protection...
April 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28412346/superoxide-is-the-critical-driver-of-dopal-autoxidation-lysyl-adduct-formation-and-crosslinking-of-%C3%AE-synuclein
#9
Jon W Werner-Allen, Rodney L Levine, Ad Bax
Parkinson's disease has long been associated with redox imbalance and oxidative stress in dopaminergic neurons. The catecholaldehyde hypothesis proposes that 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate product of dopamine catabolism, is a central nexus in a network of pathways leading to disease-state neurodegeneration, owing to its toxicity and potent ability to oligomerize α-synuclein, the main component of protein aggregates in Lewy bodies. In this work we examine the connection between reactive oxygen species and DOPAL autoxidation...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28411232/wnt5a-regulates-adipose-tissue-angiogenesis-via-anti-angiogenic-vegfa165b-in-obese-humans
#10
Shakun Karki, Doan Ngo, Melissa G Farb, Song-Young Park, Samantha M Saggese, Naomi M Hamburg, Brian Carmine, Donald T Hess, Kenneth Walsh, Noyan Gokce
Experimental studies suggest that Wingless-related integration site 5a (WNT5A) is a pro-inflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation and metabolic dysfunction. We recently demonstrated that impaired adipose tissue angiogenesis is associated with overexpression of anti-angiogenic factor VEGF-A165b in human fat and the systemic circulation...
April 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28406041/the-nexus-between-health-and-time-use-among-racially-and-ethnically-diverse-women
#11
Cathleen D Zick, Iris Buder, Norman J Waitzman, Sara Simonsen, Kathleen Digre
OBJECTIVES: Ethnic and racial health disparities have been well-documented in the scholarly literature. In recent years, evidence about time spent in physical (in)activity and its relationship to physical and mental health has also emerged. This study assesses if observed ethnic/racial health differences were associated with differences in time use. DESIGN: Our analyses utilized baseline data from 510 Utah women who enrolled in one of two community-based, participatory research intervention studies between 2012 and 2015...
April 13, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28402134/cultivating-the-therapeutic-self-in-china
#12
Li Zhang
Facing intensified market competition and rapid social change, many Chinese are experiencing increased mental distress. In this article, I examine how psychological training and interventions play a vital part in cultivating a new self among urban middle-classes. I ask how the Chinese notion, ziwo (self), is turned into an object of intense inquiry and how therapeutic techniques are deployed for self-development. The new forms of the self however continue to intersect with and complicate the existing social nexus, cultural sensibilities, and notions of personhood...
April 12, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28400602/first-direct-evidence-of-pan-african-orogeny-associated-with-gondwana-assembly-in-the-cathaysia-block-of-southern-china
#13
Longming Li, Shoufa Lin, Guangfu Xing, Yang Jiang, Jian He
Metamorphic zircon from a hornblendite in the South China Block (SCB) yield U-Pb age of 533 ± 7 Ma and Hf model ages from 900 to 1200 Ma. Geochemical and isotopic characteristics indicate that primary magma of the hornblendites was probably derived from an enriched asthenospheric mantle source. This Late Neoproterozoic-Cambrian (Pan-African) metamorphic event provides the first direct evidence that the SCB was an integral part of the Gondwana assembly. Combined with available geological data which show that the SCB has great affinity with India or Australia, the Pan-African metamorphic event most likely belongs to the eastern Kuunga orogeny...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389106/development-of-the-green-garden-resources-education-and-environment-nexus-tool-an-evidence-based-model-for-school-garden-integration
#14
Kate Gardner Burt, Pamela Koch, Isobel Contento
BACKGROUND: Researchers have established the benefits of school gardens on students' academic achievement, dietary outcomes, physical activity, and psychosocial skills, yet limited research has been conducted about how school gardens become institutionalized and sustained. OBJECTIVE: Our aim was to develop a tool that captures how gardens are effectively established, integrated, and sustained in schools. DESIGN: We conducted a sequential, exploratory, mixed-methods study...
April 4, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28386891/energy-water-food-nexus-under-financial-constraint-environment-good-the-bad-and-the-ugly-sustainability-reforms-in-sub-saharan-african-countries
#15
Khalid Zaman, Sadaf Shamsuddin, Mehboob Ahmad
Environmental sustainability agenda are generally compromised by energy, water, and food production resources, while in the recent waves of global financial crisis, it mediates to increase the intensity of air pollutants, which largely affected the less developing countries due to their ease of environmental regulation policies and lack of optimal utilization of economic resources. Sub-Saharan African (SSA) countries are no exception that majorly hit by the recent global financial crisis, which affected the country's natural environment through the channel of unsustainable energy-water-food production...
April 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28386618/decoding-chemical-communication-in-nematodes
#16
Rebecca A Butcher
The nematode Caenorhabditis elegans produces tens, if not hundreds, of different ascarosides as pheromones to communicate with other members of its species. Overlapping mixtures of these pheromones affect the development of the worm and a variety of different behaviors. The ascarosides represent a unique tool for dissecting the neural circuitry that controls behavior and that connects to important signaling pathways, such as the insulin and TGFβ pathways, that lie at the nexus of development, metabolism, and lifespan in C...
April 7, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28386091/the-calcium-cancer-signalling-nexus
#17
REVIEW
Gregory R Monteith, Natalia Prevarskaya, Sarah J Roberts-Thomson
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past decade there has been a deeper understanding of how calcium signalling is remodelled in some cancers and the consequences of calcium signalling on key events such as proliferation, invasion and sensitivity to cell death...
April 7, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28385577/carbamates-and-ich-m7-classification-making-use-of-expert-knowledge
#18
Rachel Hemingway, Adrian Fowkes, Richard V Williams
Carbamates are widely used in the chemical industry so understanding their toxicity is important to safety assessment. Carbamates have been associated with certain toxicities resulting in publication of structural alerts, including alerts for mutagenicity. Structural alerts for bacterial mutagenicity can be used in combination with statistical systems to enable ICH M7 classification, which allows assessment of the genotoxic risk posed by pharmaceutical impurities. This study tested a hypothetical bacterial mutagenicity alert for carbamates and examined the impact it would have on ICH M7 classifications using QSAR predictions from the expert rule-based system Derek Nexus and the statistical-based system Sarah Nexus...
April 3, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28379196/endoplasmic-reticulum-stress-and-oxidative-stress-a-vicious-nexus-implicated-in-bowel-disease-pathophysiology
#19
REVIEW
Wai Chin Chong, Madhur D Shastri, Rajaraman Eri
The endoplasmic reticulum (ER) is a complex protein folding and trafficking organelle. Alteration and discrepancy in the endoplasmic reticulum environment can affect the protein folding process and hence, can result in the production of misfolded proteins. The accumulation of misfolded proteins causes cellular damage and elicits endoplasmic reticulum stress. Under such stress conditions, cells exhibit reduced functional synthesis, and will undergo apoptosis if the stress is prolonged. To resolve the ER stress, cells trigger an intrinsic mechanism called an unfolded protein response (UPR)...
April 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28368194/social-rejection-magnifies-impulsive-behavior-among-individuals-with-greater-negative-urgency-an-experimental-test-of-urgency-theory
#20
David S Chester, Donald R Lynam, Richard Milich, C Nathan DeWall
Impulsivity is a multifaceted trait with substantial implications for human well-being. One facet of impulsivity is negative urgency, the tendency to act impulsively in response to negative affect. Correlational evidence suggests that negative affect magnifies impulsive behavior among individuals with greater negative urgency, yet causal evidence for this core pillar of urgency theory is lacking. To fill this gap in the literature, participants (N = 363) were randomly assigned to experience social rejection (a situation shown to induce negative affect) or acceptance...
April 3, 2017: Journal of Experimental Psychology. General
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