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https://www.readbyqxmd.com/read/29667761/plant-glycosylphosphatidylinositol-gpi-anchored-proteins-at-the-plasma-membrane-cell-wall-nexus
#1
REVIEW
Trevor H Yeats, Antony Bacic, Kim L Johnson
Approximately 1% of plant proteins are predicted to be post-translationally modified with a glycosylphosphatidylinositol (GPI) anchor that tethers the polypeptide to the outer leaflet of the plasma membrane. While the synthesis and structure of GPI anchors is largely conserved across eukaryotes, the repertoire of functional domains present in the GPI-anchored proteome has diverged substantially. In plants, this includes a large fraction of the GPI-anchored proteome being further modified with plant-specific arabinogalactan (AG) O-glycans...
April 18, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29665151/validation-of-the-pediatric-nexus-ii-head-ct-decision-instrument-for-selective-imaging-of-pediatric-patients-with-blunt-head-trauma
#2
Malkeet Gupta, William R Mower, Robert M Rodriguez, Gregory W Hendey
BACKGROUND: Data suggests that clinicians, when evaluating pediatric patients with blunt head trauma, may be over-ordering head computed tomography. Prior decision instruments aimed at aiding clinicians in safely forgoing CTs may be paradoxically increasing CT utilization. This study evaluated a novel decision instrument that aims for high sensitivity while also improving specificity over prior instruments. METHODS: We conducted a planned secondary analysis of the NEXUS Head CT decision instrument (DI) among patients less than 18 years old...
April 17, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29661037/lysosomes-and-brain-health
#3
Jaiprakash Sharma, Alberto di Ronza, Parisa Lotfi, Marco Sardiello
One of the fundamental properties of the cell is the capability to digest and remodel its own components according to metabolic and developmental needs. This is accomplished via the autophagy-lysosome system, a pathway of critical importance in the brain, where it contributes to neuronal plasticity and must protect nonreplaceable neurons from the potentially harmful accumulation of cellular waste. The study of lysosomal biogenesis and function in the context of common and rare neurodegenerative diseases has revealed that a dysfunctional autophagy-lysosome system is the shared nexus where multiple, interconnected pathogenic events take place...
April 16, 2018: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/29657967/at-the-nexus-of-history-ecology-and-hydrobiogeochemistry-improved-predictions-across-scales-through-integration
#4
James C Stegen
To improve predictions of ecosystem function in future environments, we need to integrate the ecological and environmental histories experienced by microbial communities with hydrobiogeochemistry across scales. A key issue is whether we can derive generalizable scaling relationships that describe this multiscale integration. There is a strong foundation for addressing these challenges. We have the ability to infer ecological history with null models and reveal impacts of environmental history through laboratory and field experimentation...
March 2018: MSystems
https://www.readbyqxmd.com/read/29653287/detecting-the-functional-complexities-between-high-density-lipoprotein-mimetics
#5
Yoshitaka J Sei, Jungho Ahn, Taeyoung Kim, Eunjung Shin, Angel J Santiago-Lopez, Seung Soon Jang, Noo Li Jeon, Young C Jang, YongTae Kim
High-density lipoprotein (HDL) is a key regulator of lipid homeostasis through its native roles like reverse cholesterol transport. The reconstitution of this natural nanoparticle (NP) has become a nexus between nanomedicine and multi-disease therapies, for which a major portion of HDL functionality is attributed to its primary scaffolding protein, apolipoprotein A1 (apoA1). ApoA1-mimetic peptides were formulated as cost-effective alternatives to apoA1-based therapies; reverse-4F (r4F) is one such peptide used as part of a nanoparticle platform...
April 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29653028/rna-localization-regulates-diverse-and-dynamic-cellular-processes
#6
REVIEW
Pearl V Ryder, Dorothy A Lerit
At the nexus of specialized cellular responses are localized enrichments of protein activity. The localization of messenger RNA (mRNA) coupled with translational control often plays a crucial role in the generation of protein concentrations at defined subcellular domains. Although mRNA localization is classically associated with large specialized cells, such as neurons and embryos, RNA localization is a highly conserved paradigm of post-transcriptional regulation observed in diverse cellular contexts. Functions of localized mRNAs extend far beyond the well-studied examples of neuronal polarization and developmental patterning...
April 13, 2018: Traffic
https://www.readbyqxmd.com/read/29650058/roles-of-instrumented-farm-scale-trials-in-trade-off-assessments-of-pasture-based-ruminant-production-systems
#7
T Takahashi, P Harris, M S A Blackwell, L M Cardenas, A L Collins, J A J Dungait, J M B Hawkins, T H Misselbrook, G A McAuliffe, J N McFadzean, P J Murray, R J Orr, M J Rivero, L Wu, M R F Lee
For livestock production systems to play a positive role in global food security, the balance between their benefits and disbenefits to society must be appropriately managed. Based on the evidence provided by field-scale randomised controlled trials around the world, this debate has traditionally centred on the concept of economic-environmental trade-offs, of which existence is theoretically assured when resource allocation is perfect on the farm. Recent research conducted on commercial farms indicates, however, that the economic-environmental nexus is not nearly as straightforward in the real world, with environmental performances of enterprises often positively correlated with their economic profitability...
April 13, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29648461/using-two-eyed-seeing-to-explore-interagency-collaboration
#8
Cheryl Whiting, Stephanie Cavers, Sandra Bassendowski, Pammla Petrucka
Background Health-care environments influence service delivery; approaches need to be more wholistic and culturally competent requiring effective interagency collaboration to bridge traditional Indigenous and mainstream health services. Despite considerable research on collaboration, the concept remains misunderstood, at worst, and formative, at best. Within the nexus of these two diverse health services, there is limited information on how collaborations could be created and sustained effectively. Purpose To explore the perspectives/experiences of collaboration of select Saskatchewan health professionals practicing across these diverse services to understand the concept from their perspectives...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/29618537/linking-mental-disorder-and-risk-in-sexually-violent-person-assessments
#9
Linda E Weinberger, Shoba Sreenivasan, Allen Azizian, Thomas Garrick
A common criticism of sexually violent person (SVP) laws is that psychiatric commitment has been co-opted to continue the incarceration of dangerous criminals, not dangerous individuals with mental illness. This opinion may have credence because some forensic clinicians use a "silo" approach (i.e., diagnosing based on historical criminal behavior rather than current symptomatology, and formulating risk for future sexual violence based on actuarial scores rather than characteristics and features of the mental condition)...
March 2018: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/29614465/running-at-submaximal-speeds-the-role-of-the-intact-and-prosthetic-limbs-for-trans-tibial-amputees
#10
Siobhan C Strike, Daniela Acrone, Michael Orendurff
BACKGROUND: Dynamic Elastic Response prostheses are designed absorb and return strain energy in running. Past research has focused on running prostheses with a single toe spring designed for high speeds. RESEARCH QUESTION: To determine how runners with amputation modulate the ground reaction force of each limb to run at different speeds using a general-purpose dynamic prosthesis which has a heel spring. METHODS: Overground running data were collected in 16 recreational runners (8 transtibial amputee using their own BladeXT prosthesis and 8 controls) using Vicon Nexus V...
March 27, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29614380/serotonin-as-a-link-between-the-gut-brain-microbiome-axis-in-autism-spectrum-disorders
#11
REVIEW
Narek Israelyan, Kara Gross Margolis
Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a correlation between GI dysfunction and the degree of social impairment in ASD. The etiology of GI abnormalities in ASD is unclear, though the association between GI dysfunction and ASD-associated behaviors suggest that overlapping developmental defects in the brain and the intestine and/or a defect in communication between the enteric and central nervous systems (ENS and CNS, respectively), known as the gut-brain axis, could be responsible for the observed phenotypes...
March 31, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29602526/differences-in-the-health-age-profile-across-rural-and-urban-sectors-a-study-on-migrants-and-non-migrants-in-china
#12
Y Tong, M Piotrowski, H Ye
OBJECTIVES: The objective of this study is to examine age-health differentials between migrants and non-migrants in the context of migration in China. STUDY DESIGN: We use nationally representative data from the China Labor-force Dynamics Survey to analyze the relationship between age and health across different migration status groups. METHODS: We used a comprehensive measure of perceived health from factor analysis and structural equation models to take multiple dimensions of subjective health into consideration...
March 27, 2018: Public Health
https://www.readbyqxmd.com/read/29600379/a-new-approach-to-the-renewable-energy-growth-nexus-evidence-from-the-usa
#13
Giray Gozgor
The climate change is one of the leading problems in the today's world. The rise of the renewable energy meets the sustainable growth objectives since it can decelerate the climate change. For this purpose, this paper investigates the relationship between the renewable energy consumption and the economic growth in the United States (USA). Theoretically, the paper constructs the growth model that captures the effects of the economic complexity indicator as a measure of capabilities and productivity for exporting the "complex" (high value-added) products...
March 29, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29596517/does-farmer-entrepreneurship-alleviate-rural-poverty-in-china-evidence-from-guangxi-province
#14
Eric Yaw Naminse, Jincai Zhuang
In recent years, entrepreneurship has been gaining more prominence as a potential tool for solving poverty in developing countries. This paper mainly examines the relationship between farmer entrepreneurship and rural poverty alleviation in China by assessing the contribution of farm entrepreneurs towards overcoming poverty. Data were collected from 309 employees of farmer entrepreneurships in Guangxi Province through survey questionnaires. Structural equation modeling was used to conduct an analysis of the effects of three identified capabilities of farm entrepreneurs-economic, educational and knowledge, and socio-cultural capabilities-on attitude towards farmer entrepreneurship growth and the qualitative growth of farmer entrepreneurship and how these in turn affect rural poverty, using AMOS 21...
2018: PloS One
https://www.readbyqxmd.com/read/29592809/exploring-the-potential-of-black-tea-based-flavonoids-against-hyperlipidemia-related-disorders
#15
Ali Imran, Masood Sadiq Butt, Muhammad Sajid Arshad, Muhammad Umair Arshad, Farhan Saeed, Muhammad Sohaib, Rizwan Munir
BACKGROUND: In recent decade, Hyperlipidemia related disorders like obesity, hypercholesterolemia and diabetes are considered as the leading killers for mankind. Fundamental nexus between nutrition and health diverting the consumers focus towards plant based natural products as a remedy against various metabolic syndrome. Considering this, present study was conducted to explicate the role of black tea polyphenols such as Theaflavins and thearubigins therapeutic potential to tackle targeted maladies especially oxidative stress related disorders like hypercholesterolemia and diabetes...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29592787/theoretical-underpinnings-of-state-institutionalisation-of-inclusion-and-struggles-in-collective-health-in-latin-america
#16
Qamar Mahmood, Carles Muntaner
Community participation as a strategy in health aims to increase the role of citizens in health decision-making which are contextualised within the institutions of democracy. Electoral representation as the dominant model of democracy globally is based on the elite theory of democracy that sees political decision-making a prerogative of political elites. Such political elitism is counter to the idea of democratic participation. Neoliberalism together with elitism in political sphere have worsened social inequities by undermining working class interests...
March 28, 2018: Global Public Health
https://www.readbyqxmd.com/read/29588157/gp2-5-the-multifunctional-bacteriophage-t7-single-stranded-dna-binding-protein
#17
REVIEW
Alfredo J Hernandez, Charles C Richardson
The essential bacteriophage T7-encoded single-stranded DNA binding protein is the nexus of T7 DNA metabolism. Multiple layers of macromolecular interactions mediate its function in replication, recombination, repair, and the maturation of viral genomes. In addition to binding ssDNA, the protein binds to DNA polymerase and DNA helicase, regulating their activities. The protein displays potent homologous DNA annealing activity, underscoring its role in recombination.
March 24, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29584539/effectiveness-of-the-i-2-ao-2-interdisciplinary-programme-led-by-nurses-on-metabolic-syndrome-and-cardiovascular-risk-a-randomized-controlled-trial
#18
V E Fernández-Ruiz, J A Paniagua-Urbano, M Solé-Agustí, A Ruiz-Sánchez, J Gómez-Marín, D Armero-Barranco
Objective To evaluate the effectiveness of an interdisciplinary programme led by nurses in relation to metabolic syndrome (MS) and cardiovascular risk (CVR). Methods This randomized, controlled, clinical trial included 74 patients diagnosed with MS (experimental group [EG], n = 37; control group [CG], n = 37). The intervention consisted of a 12-month interdisciplinary programme (pre-test, 6 months of intervention, 12 months of intervention, and 1-year follow-up post-intervention) coordinated by nursing...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29579699/social-cohesion-and-self-rated-health-among-adults-in-south-africa-the-moderating-role-of-race
#19
Emmanuel O Olamijuwon, Clifford O Odimegwu, Nicole De Wet
In African countries including South Africa, the nexus between social cohesion and health remains under-researched. Using data from the 2012 South African social attitudes survey with a sample of 1988 adults in South Africa aged 18 years or older, we used the collective efficacy theory by Sampson and colleagues to examine the relationship between social cohesion and self-rated health in an African sample. We also examined how this relationship differed by race. Results from the multivariate analysis after adjusting for covariates suggested that adults in the highest tertile of social cohesion were more likely to report moderate or good health compared to those in the lowest tertile...
March 23, 2018: Health & Place
https://www.readbyqxmd.com/read/29579255/performance-of-in-silico-models-for-mutagenicity-prediction-of-food-contact-materials
#20
Melissa Van Bossuyt, Els Van Hoeck, Giuseppa Raitano, Tamara Vanhaecke, Emilio Benfenati, Birgit Mertens, Vera Rogiers
In silico methodologies, such as (quantitative) structure-activity relationships ((Q)SARs), are available to predict a wide variety of toxicological properties and biological activities for structurally diverse substances. To obtain insights in the scientific value of these predictions, the capacity of the prediction models to generate (sufficiently) reliable results for a particular type of compounds needs to be evaluated. In the current study, performance parameters to predict the endpoint 'bacterial mutagenicity' were calculated for a battery of common (Q)SAR tools, namely Toxtree, Derek Nexus, VEGA Consensus and Sarah Nexus...
March 20, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
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