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https://www.readbyqxmd.com/read/29020659/3d-gait-analysis-with-and-without-an-orthopedic-walking-boot
#1
H Gulgin, K Hall, A Luzadre, E Kayfish
INTRODUCTION: Orthopedic walking boots have been widely used in place of traditional fiberglass casts for a variety of orthopedic injuries and post-surgical interventions. These walking boots create a leg length discrepancy (LLD). LLD has been shown to alter the kinematics and kinetics of gait and are associated with lumbar and lower limb conditions such as: foot over pronation, low back pain, scoliosis, and osteoarthritis of the hip and knee joints. Past gait analyses research with orthopedic boots is limited to findings on the ipsilateral limb...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29017141/premonitory-urges-and-tics-in-tourette-syndrome-computational-mechanisms-and-neural-correlates
#2
REVIEW
Vasco A Conceição, Ângelo Dias, Ana C Farinha, Tiago V Maia
Tourette syndrome is characterized by open motor behaviors - tics - but another crucial aspect of the disorder is the presence of premonitory urges: uncomfortable sensations that typically precede tics and are temporarily alleviated by tics. We review the evidence implicating the somatosensory cortices and the insula in premonitory urges and the motor cortico-basal ganglia-thalamo-cortical loop in tics. We consider how these regions interact during tic execution, suggesting that the insula plays an important role as a nexus linking the sensory and emotional character of premonitory urges with their translation into tics...
October 7, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29016985/the-effect-of-various-adhesives-enamel-etching-and-base-treatment-on-the-failure-frequency-of-customized-lingual-brackets-a-randomized-clinical-trial
#3
Dimitrios Mavreas, Jean-François Cuzin, Guillaume Boonen, Bart Vande Vannet
Objectives: The aim of this paper was to compare failure differences in precious metal customized lingual brackets bonded with three adhesive systems. Also, differences in failure of non-precious metal brackets with and without a silicatized base layer bonded with the same adhesive, as well as the influence of enamel etching prior to using a self-etching dual cure resin were explored. Materials/methods: Five different groups were defined in a semi-randomized approach...
July 10, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28988960/pdim-and-sl1-accumulation-in-mycobacterium-tuberculosis-is-associated-with-mce4a-expression
#4
Pooja Singh, Rajesh Sinha, Gaurav Tyagi, Naresh Kumar Sharma, Neeraj K Saini, Amita Chandolia, Ashok Kumar Prasad, Mandira Varma-Basil, Mridula Bose
Lipid metabolism forms the heart and soul of Mycobacterium tuberculosis life cycle. Starting from macrophage invasion at cholesterol rich micro-domains to a sustainable survival for infection by utilizing cholesterol, Mycobacterium displays the nexus of metabolic pathways around host derived lipids. mce4 operon acts as cholesterol import system in M. tuberculosis and here we demonstrate role of mce4A gene of this operon in cholesterol catabolism. Here M. tuberculosis H37Rv overexpressing Rv3499c (mce4A) recombinant was used as a model to decipher the metabolic flux during intake and utilization of host lipids by mycobacteria...
October 5, 2017: Gene
https://www.readbyqxmd.com/read/28985560/ferroptosis-a-regulated-cell-death-nexus-linking-metabolism-redox-biology-and-disease
#5
REVIEW
Brent R Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascón, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, K A Woerpel, Donna D Zhang
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q10...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28983879/capturing-forest-dependency-in-the-central-himalayan-region-variations-between-oak-quercus-spp-and-pine-pinus-spp-dominated-forest-landscapes
#6
Anusheema Chakraborty, Pawan Kumar Joshi, Kamna Sachdeva
Our study explores the nexus between forests and local communities through participatory assessments and household surveys in the central Himalayan region. Forest dependency was compared among villages surrounded by oak-dominated forests (n = 8) and pine-dominated forests (n = 9). Both quantitative and qualitative analyses indicate variations in the degree of dependency based on proximity to nearest forest type. Households near oak-dominated forests were more dependent on forests (83.8%) compared to households near pine-dominated forests (69...
October 5, 2017: Ambio
https://www.readbyqxmd.com/read/28983429/hepatitis-c-understanding-factors-that-influence-the-physicians-treatment-decisions
#7
Celine Miani, Catriona Manville, Peter Burge, Sonja Marjanovic, Joanna Chataway
This study aimed to inform Hepatitis C (HCV) treatment by (1) better understanding the nexus of factors physicians consider when making HCV treatment decisions; (2) investigating the comparative influence and importance of specific factors and the trade-offs implicated in the decisionmaking process; and (3) examining how much thrombocytopenia impacts treatment decisions and how it impacts treatment. To meet this goal, we conducted five analyses, focusing on four European countries characterised by different approaches to healthcare organisation and financing, which alongside cultural differences may have potential implications for treatment pathways for patients with HCV infection...
January 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28982760/znf281-enhances-cardiac-reprogramming-by-modulating-cardiac-and-inflammatory-gene-expression
#8
Huanyu Zhou, Maria Gabriela Morales, Hisayuki Hashimoto, Matthew E Dickson, Kunhua Song, Wenduo Ye, Min S Kim, Hanspeter Niederstrasser, Zhaoning Wang, Beibei Chen, Bruce A Posner, Rhonda Bassel-Duby, Eric N Olson
Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblasts but not adult fibroblasts. To identify additional regulators of adult cardiac reprogramming, we performed an unbiased screen of transcription factors and cytokines for those that might enhance or suppress the cardiogenic activity of AGHMT in adult mouse fibroblasts...
September 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28982073/cardiac-specific-inactivation-of-lpp3-in-mice-leads-to-myocardial-dysfunction-and-heart-failure
#9
Mini Chandra, Diana Escalante-Alcalde, Md Shenuarin Bhuiyan, Anthony Wayne Orr, Christopher Kevil, Andrew J Morris, Hyung Nam, Paari Dominic, Kevin J McCarthy, Sumitra Miriyala, Manikandan Panchatcharam
Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA). To study the role of LPP3 in the myocardium, we generated a cardiac specific Plpp3 deficient mouse strain. Although these mice were viable at birth in contrast to global Plpp3 knockout mice, they showed increased mortality ~ 8 months. LPP3 deficient mice had enlarged hearts with reduced left ventricular performance as seen by echocardiography. Cardiac specific Plpp3 deficient mice had longer ventricular effective refractory periods compared to their Plpp3 littermates...
September 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/28976736/emissions-of-glyoxal-and-other-carbonyl-compounds-from-agricultural-biomass-burning-plumes-sampled-by-aircraft
#10
Kyle J Zarzana, Kyung-Eun Min, Rebecca A Washenfelder, Jennifer Kaiser, Mitchell Krawiec-Thayer, Jeff Peischl, J Andrew Neuman, John B Nowak, Nicholas L Wagner, William P Dubè, Jason M St Clair, Glenn M Wolfe, Thomas F Hanisco, Frank N Keutsch, Thomas B Ryerson, Steven S Brown
We report enhancements of glyoxal and methylglyoxal relative to carbon monoxide and formaldehyde in agricultural biomass burning plumes intercepted by the NOAA WP-3D aircraft during the 2013 Southeast Nexus and 2015 Shale Oil and Natural Gas Nexus campaigns. Glyoxal and methylglyoxal were measured using broadband cavity enhanced spectroscopy, which for glyoxal provides a highly selective and sensitive measurement. While enhancement ratios of other species such as methane and formaldehyde were consistent with previous measurements, glyoxal enhancements relative to carbon monoxide averaged 0...
October 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28975440/research-priorities-for-the-intersection-of-alcohol-and-hiv-aids-in-low-and-middle-income-countries-a-priority-setting-exercise
#11
Sara Gordon, Mary Jane Rotheram-Borus, Sarah Skeen, Charles Perry, Kendall Bryant, Mark Tomlinson
The harmful use of alcohol is a component cause for more than 200 diseases. The association between alcohol consumption, risk taking behavior and a range of infectious diseases such as HIV/AIDS is well established. The prevalence of HIV/AIDS as well as harmful alcohol use in low and middle income countries is high. Alcohol has been identified as a modifiable risk factor in the prevention and treatment of HIV/AIDS. The objective of this paper is to define research priorities for the interaction of alcohol and HIV/AIDS in low and middle income countries...
October 3, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28970620/a-systematic-review-of-assessment-tools-measuring-interprofessional-education-outcomes-relevant-to-pharmacy-education
#12
REVIEW
Sarah Shrader, Michelle Z Farland, Jennifer Danielson, Brigitte Sicat, Elena M Umland
Objective. To identify and describe the available quantitative tools that assess interprofessional education (IPE) relevant to pharmacy education. Methods. A systematic approach was used to identify quantitative IPE assessment tools relevant to pharmacy education. The search strategy included the National Center for Interprofessional Practice and Education Resource Exchange (Nexus) website, a systematic search of the literature, and a manual search of journals deemed likely to include relevant tools. Results...
August 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28967395/simplified-cementation-of-lithium-disilicate-crowns-retention-with-various-adhesive-resin-cement-combinations
#13
Glen H Johnson, Xavier Lepe, Amanda Patterson, Oliver Schäfer
STATEMENT OF PROBLEM: A composite resin cement and matching self-etch adhesive was developed to simplify the dependable retention of lithium disilicate crowns. The efficacy of this new system is unknown. PURPOSE: The purpose of this in vitro study was to determine whether lithium disilicate crowns cemented with a new composite resin and adhesive system and 2 other popular systems provide clinically acceptable crown retention after long-term aging with monthly thermocycling...
September 27, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28967301/meeting-abstracts-academy-of-managed-care-pharmacy-nexus-2017
#14
(no author information available yet)
The AMCP Abstracts program provides a forum through which authors can share their insights and outcomes of advanced managed care practice through publication in AMCP's Journal of Managed Care & Specialty Pharmacy (JMCP). Abstracts that have been reviewed are published in the JMCP Meeting Abstracts supplement. Poster presentations for AMCP Nexus 2017 are scheduled for Wednesday, October 18, from 12:00 pm to 2:45 pm. For each poster, at least 1 author is available during the poster presentations to discuss findings...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28959184/mitophagy-failure-in-fibroblasts-and-ipsc-derived-neurons-of-alzheimer-s-disease-associated-presenilin-1-mutation
#15
Patricia Martín-Maestro, Ricardo Gargini, Andrew A Sproul, Esther García, Luis C Antón, Scott Noggle, Ottavio Arancio, Jesús Avila, Vega García-Escudero
Familial Alzheimer's disease (FAD) is clearly related with the accumulation of amyloid-beta (Aβ) and its deleterious effect on mitochondrial function is well established. Anomalies in autophagy have also been described in these patients. In the present work, functional analyses have been performed to study mitochondrial recycling process in patient-derived fibroblasts and neurons from induced pluripotent stem cells harboring the presenilin 1 mutation A246E. Mitophagy impairment was observed due to a diminished autophagy degradation phase associated with lysosomal anomalies, thus causing the accumulation of dysfunctional mitochondria labeled by Parkin RBR E3 ubiquitin protein ligase (PARK2)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28956603/allosteric-signal-transduction-in-hiv-1-restriction-factor-samhd1-proceeds-via-reciprocal-handshake-across-monomers
#16
Kajwal Kumar Patra, Akash Bhattacharya, Swati Bhattacharya
The sterile alpha motif and histidine-aspartate domain-containing protein 1 (or SAMHD1), a human dNTP-triphosphohydrolase, contributes to HIV-1 restriction in select terminally differentiated cells of the immune system. The catalytically active form of the protein is an allosterically triggered tetramer, whose HIV-1 restriction properties are attributed to its dNTP - triphosphohydrolase activity. The tetramer itself is assembled by a GTP/dNTP combination. This enzyme uses the strategy of deoxynucleotide starvation, which is thought to prevent effective reverse transcription of the retroviral genome - hence restricting HIV-1 propagation...
September 28, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28956194/fresh-perspectives-on-the-alcohol-and-hiv-nexus-a-call-for-action-in-an-era-of-increased-opportunities-and-challenges
#17
EDITORIAL
Charles D H Parry, Mark Tomlinson, Kendall Bryant, Mary Jane Rotherham-Borus
No abstract text is available yet for this article.
September 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28954508/unravelling-and-reconstructing-the-nexus-of-salinity-electricity-and-microbial-ecology-for-bioelectrochemical-desalination
#18
Heyang Yuan, Shan Sun, Ibrahim M Abu-Reesh, Brian D Badgley, Zhen He
Microbial desalination cells (MDCs) are an emerging concept for simultaneous water/wastewater treatment and energy recovery. The key to developing MDCs is to understand fundamental problems, such as the effects of salinity on system performance and the role of microbial community and functional dynamics. Herein, a tubular MDC was operated under a wide range of salt concentrations (0.05-4 M), and the salinity effects were comprehensively examined. The MDC generated higher current with higher salt concentrations in the desalination chamber...
October 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28951244/tyrosines-740-751-of-pdgfr%C3%AE-contribute-to-the-activation-of-akt-hif1%C3%AE-tgf%C3%AE-nexus-to-drive-high-glucose-induced-glomerular-mesangial-cell-hypertrophy
#19
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Glomerular mesangial cell hypertrophy contributes to the complications of diabetic nephropathy. The mechanism by which high glucose induces mesangial cell hypertrophy is poorly understood. Here we explored the role of the platelet-derived growth factor receptor-β (PDGFRβ) tyrosine kinase in driving the high glucose-induced mesangial cell hypertrophy. We show that high glucose stimulates the association of the PDGFRβ with PI 3 kinase leading to tyrosine phosphorylation of the latter. High glucose-induced Akt kinase activation was also dependent upon PDGFRβ and its tyrosine phosphorylation at 740/751 residues...
September 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28950964/emotional-influence-in-groups-the-dynamic-nexus-of-affect-cognition-and-behavior
#20
REVIEW
Gerben A van Kleef, Marc W Heerdink, Astrid C Homan
Groups are a natural breeding ground for emotions. Group life affords unique opportunities but also poses critical challenges that may arouse emotional reactions in group members. Social-functional approaches hold that these emotions in turn contribute to group functioning by prompting group members to address concerns that are relevant to the group's success. Guided by Emotions as Social Information (EASI) theory, this paper reviews research on the affective, cognitive, and behavioral consequences of emotional expressions in groups...
October 2017: Current Opinion in Psychology
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