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https://www.readbyqxmd.com/read/27902947/what-factors-affect-implementation-of-early-rehabilitation-into-intensive-care-unit-practice-a-qualitative-study-with-clinicians
#1
Selina M Parry, Louisa Remedios, Linda Denehy, Laura D Knight, Lisa Beach, Thomas C Rollinson, Sue Berney, Zudin A Puthucheary, Peter Morris, Catherine L Granger
PURPOSE: To identify the barriers and enablers that influence clinicians' implementation of early rehabilitation in critical care. MATERIALS AND METHODS: Qualitative study involving 26 multidisciplinary participants who were recruited using purposive sampling. Four focus groups were conducted using semistructured questions to explore attitudes, beliefs, and experiences. Data were transcribed verbatim and thematic analysis was performed. RESULTS: Six themes emerged, as follows: (1) the clinicians' expectations and knowledge (including rationale for rehabilitation, perceived benefits, and experience), (2) the evidence for and application of rehabilitation (including beliefs regarding when to intervene), (3) patient factors (including prognosis, sedation, delirium, cooperation, motivation, goals, and family), (4) safety considerations (including physiological stability and presence of devices or lines), (5) environmental influences (staffing, resources, equipment, time, and competing priorities), and (6) culture and teamwork...
November 12, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27742425/relation-among-clot-burden-right-sided-heart-strain-and-adverse-events-after-acute-pulmonary-embolism
#2
Praveen Hariharan, David M Dudzinski, Rachel Rosovsky, Farris Haddad, Peter MacMahon, Blair Parry, Yuchiao Chang, Christopher Kabrhel
Computed tomography pulmonary angiogram (CTPA) provides a volumetric assessment of clot burden in acute pulmonary embolism (PE). However, it is unclear if clot burden is associated with right-sided heart strain (RHS) or adverse clinical events (ACE). We prospectively enrolled Emergency Department patients with PE (in CTPA) from 2008 to 2011. We assigned 1 to 9 points as clot burden score, based on whether emboli were saddle, central, lobar, segmental, and subsegmental. We evaluated a novel score (the "CT-PASS") based on the sum (in millimeters) of the largest filling defects in the right and left pulmonary vasculature...
August 24, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27708812/a-mixed-method-study-of-pain-management-practice-in-a%C3%A2-uk-children-s-hospital-identification-of-barriers-and-developing-strategies-to-maintain-effective-in-patient-paediatric-pain-management
#3
Kate Beckett, Ellen M Henderson, Sarah Parry, Peter Stoddart, Margaret Fletcher
AIM: To assess Acute Pain Service and paediatric pain management efficacy in a UK specialist paediatric hospital to inform wider recommendations for future sustainability. BACKGROUND: UK paediatric acute pain services vary. Although comprehensive pain management guidelines exist, consensus on the best model of care is lacking. Worldwide, medical and pharmacological advances and rapid patient turnover have increased the challenges of managing hospitalized children's pain...
January 2016: Nursing Open
https://www.readbyqxmd.com/read/27686459/esicm-lives-2016-part-three-milan-italy-1-5-october-2016
#4
T Velasquez, G Mackey, J Lusk, U G Kyle, T Fontenot, P Marshall, L S Shekerdemian, J A Coss-Bu, A Nishigaki, T Yatabe, T Tamura, K Yamashita, M Yokoyama, J C Ruiz-Rodriguez, B Encina, R Belmonte, I Troncoso, P Tormos, M Riveiro, J Baena, A Sanchez, J Bañeras, J Cordón, N Duran, A Ruiz, J Caballero, X Nuvials, J Riera, J Serra, A M F Rutten, S N M van Ieperen, E P H M Der Kinderen, T Van Logten, L Kovacikova, P Skrak, M Zahorec, U G Kyle, A Akcan-Arikan, J C Silva, G Mackey, J Lusk, M Goldsworthy, L S Shekerdemian, J A Coss-Bu, D Wood, D Harrison, R Parslow, P Davis, J Pappachan, S Goodwin, P Ramnarayan, S Chernyshuk, H Yemets, V Zhovnir, S M Pulitano', S De Rosa, A Mancino, G Villa, F Tosi, P Franchi, G Conti, B Patel, H Khine, A Shah, D Sung, L Singer, S Haghbin, S Inaloo, Z Serati, M Idei, T Nomura, N Yamamoto, Y Sakai, T Yoshida, Y Matsuda, Y Yamaguchi, S Takaki, O Yamaguchi, T Goto, N Longani, S Medar, I R Abdel-Aal, A S El Adawy, H M E H Mohammed, A N Mohamed, S M Parry, L D Knight, L Denehy, N De Morton, C E Baldwin, D Sani, G Kayambu, V Z M da Silva, P Phongpagdi, Z A Puthucheary, C L Granger, J E Rydingsward, C M Horkan, K B Christopher, D McWilliams, C Jones, E Reeves, G Atkins, C Snelson, L M Aitken, J Rattray, J Kenardy, A M Hull, A Ullman, R Le Brocque, M Mitchell, C Davis, B Macfarlane, J C Azevedo, L L Rocha, F F M De Freitas, A M Cavalheiro, N M Lucinio, M S Lobato, G Ebeling, A Kraegpoeth, E Laerkner, I De Brito-Ashurst, C White, S Gregory, L G Forni, E Flowers, A Curtis, C A Wood, K Siu, K Venkatesan, J B H Muhammad, L Ng, E Seet, N Baptista, A Escoval, E Tomas, R Agrawal, R Mathew, A Varma, E Dima, E Charitidou, E Perivolioti, M Pratikaki, C Vrettou, A Giannopoulos, S Zakynthinos, C Routsi, E Atchade, S Houzé, S Jean-Baptiste, G Thabut, C Genève, S Tanaka, B Lortat-Jacob, P Augustin, M Desmard, P Montravers, F J González de Molina, S Barbadillo, R Alejandro, F Álvarez-Lerma, J Vallés, R M Catalán, E Palencia, A Jareño, R M Granada, M L Ignacio, N Cui, D Liu, H Wang, L Su, H Qiu, R Li, K Jaffal, A Rouzé, J Poissy, B Sendid, S Nseir, E Paramythiotou, M Rizos, F Frantzeskaki, A Antoniadou, S Vourli, L Zerva, A Armaganidis, J Riera, J Gottlieb, M Greer, O Wiesner, M Martínez, M Acuña, J Rello, T Welte, E Atchade, T Mignot, S Houzé, S Jean-Baptiste, G Thabut, B Lortat-Jacob, S Tanaka, P Augustin, M Desmard, P Montravers, S Soussi, E Dudoignon, A Ferry, M Chaussard, M Benyamina, A Alanio, S Touratier, M Chaouat, M Lafaurie, M Mimoun, A Mebazaa, M Legrand, M A Sheils, C Patel, L Mohankumar, N Akhtar, S K Pacheco Noriega, N Navarrete Aldana, J L Ávila León, J Durand Baquero, F Fernández Bernal, E Ahmadnia, J S Hadley, M Millar, D Hall, H Hewitt, H Yasuda, M Sanui, T Komuro, S Kawano, K Andoh, H Yamamoto, E Noda, J Hatakeyama, N Saitou, H Okamoto, A Kobayashi, T Takei, S Matsukubo, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Gimillo, O Diaz Barinas, M L Blasco Cortes, J Ferreres Franco, J M Segura Roca, A Carratalá, B Gonçalves, R Turon, A Mendes, F Miranda, P J Mata, D Cavalcanti, N Melo, P Lacerda, P Kurtz, C Righy, L E de la Cruz Rosario, S P Gómez Lesmes, J C García Romero, A N García Herrera, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J Barado Hualde, A Ansotegui Hernández, J M Guergué Irazabal, V Spatenkova, O Bradac, P Suchomel, T Urli, E Heusch Lazzeri, R Aspide, M Zanello, L Perez-Borrero, J M Garcia-Alvarez, M D Arias-Verdu, E Aguilar-Alonso, R Rivera-Fernandez, J Mora-Ordoñez, C De La Fuente-Martos, E Castillo-Lorente, F Guerrero-Lopez, S P Gómez Lesmes, L E De la Cruz Rosario, E D Díaz Pertuz, A Ansotegui Hernández, J C García Romero, M J Gómez Sánchez, A N García Herrera, J Roldán Ramírez, E Regidor Sanz, J Barado Hualde, J P Tirapu León, L Navarro-Guillamón, S Cordovilla-Guardia, A Iglesias-Santiago, F Guerrero-López, E Fernández-Mondéjar, A Vidal, M Perez, A Juez, N Arias, L Colino, J L Perez, H Pérez, P Calpe, M A Alcala, D Robaglia, C Perez, S K Lan, M M Cunha, T Moreira, F Santos, E Lafuente, M J Fernandes, J G Silva, L E de la Cruz Rosario, S P Gómez Lesmes, A N García Herrera, J C García Romero, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J G Armando Echeverría, A Ansotegui Hernández, J Barado Hualde, V Podlepich, E Sokolova, E Alexandrova, K Lapteva, P Kurtz, C Shuinotsuka, L Rabello, G Vianna, A Reis, C Cairus, J Salluh, F Bozza, J C Barrios Torres, N J Fernández Araujo, P García-Olivares, E Keough, M Dalorzo, L K Tang, I De Sousa, M Díaz, L J Marcos-Zambrano, J E Guerrero, S E Zamora Gomez, G D Hernandez Lopez, A I Vazquez Cuellar, O R Perez Nieto, J A Castanon Gonzalez, D Bhasin, S Rai, H Singh, O Gupta, M K Bhattal, S Sampley, K Sekhri, R Nandha, F A Aliaga, F Olivares, F Appiani, P Farias, F Alberto, A Hernández, S Pons, R Sonneville, L Bouadma, M Neuville, E Mariotte, A Radjou, J Lebut, S Chemam, G Voiriot, M P Dilly, B Mourvillier, R Dorent, P Nataf, M Wolff, J F Timsit, O Ediboglu, S Ataman, H Ozkarakas, C Kirakli, A Vakalos, V Avramidis, O Obukhova, I A Kurmukov, S Kashiya, E Golovnya, V N Baikova, T Ageeva, T Haritydi, E V Kulaga, J J Rios-Toro, L Perez-Borrero, E Aguilar-Alonso, M D Arias-Verdu, J M Garcia-Alvarez, C Lopez-Caler, C De La Fuente-Martos, S Rodriguez-Fernandez, M Gomez Sanchez-Orézzoli, F Martin-Gallardo, J Nikhilesh, V Joshi, E Villarreal, J Ruiz, M Gordon, A Quinza, J Gimenez, M Piñol, A Castellanos, P Ramirez, Y D Jeon, W Y Jeong, M H Kim, I Y Jeong, M Y Ahn, J Y Ahn, S H Han, J Y Choi, Y G Song, J M Kim, N S Ku, H Shah, F Kellner, F Rezai, N Mistry, P Yodice, V Ovnanian, K Fless, E Handler, R Martínez Alejos, J D Martí Romeu, D González Antón, A Quinart, A Torres Martí, M Llaurado-Serra, A Lobo-Civico, A Ventura-Rosado, A Piñol-Tena, M Pi-Guerrero, C Paños-Espinosa, M Peralvo-Bernat, J Marine-Vidal, R Gonzalez-Engroba, N Montesinos-Cerro, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, S Helyar, P Riozzi, A Noon, G Hallows, H Cotton, J Keep, P A Hopkins, A Taggu, S Renuka, S Sampath, P J T Rood, T Frenzel, R Verhage, M Bonn, P Pickkers, J G van der Hoeven, M van den Boogaard, F Corradi, L Melnyk, F Moggia, R Pienovi, G Adriano, C Brusasco, L Mariotti, M Lattuada, M J Bloomer, M Coombs, K Ranse, R Endacott, B Maertens, K Blot, S Blot, M P van Nieuw Amerongen, E S van der Heiden, J W R Twisk, A R J Girbes, J J Spijkstra, P Riozzi, S Helyar, H Cotton, G Hallows, A Noon, C Bell, K Peters, A Feehan, J Keep, P A Hopkins, K Churchill, K Hawkins, R Brook, N Paver, R Endacott, N Maistry, A van Wijk, N Rouw, T van Galen, S Evelein-Brugman, A Taggu, B Krishna, S Sampath, A Putzu, M Fang, M Boscolo Berto, A Belletti, T Cassina, L Cabrini, M Mistry, Y Alhamdi, I Welters, S T Abrams, C H Toh, H S Han, E M Gil, D S Lee, C M Park, S Winder-Rhodes, R Lotay, J Doyle, M W Ke, W C Huang, C H Chiang, W T Hung, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, C W Shu, P L Kang, G Y Mar, C P Liu, S Dubó, A Aquevedo, M Jibaja, D Berrutti, C Labra, R Lagos, M F García, V Ramirez, M Tobar, F Picoita, C Peláez, D Carpio, L Alegría, C Hidalgo, K Godoy, J Bakker, G Hernández, Y Sadamoto, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, H Marin-Mateos, J L Perez-Vela, R Garcia-Gigorro, M A Corres Peiretti, M J Lopez-Gude, S Chacon-Alves, E Renes-Carreño, J C Montejo-González, K L Parlevliet, H R W Touw, M Beerepoot, C Boer, P W G Elbers, P R Tuinman, S A Abdelmonem, T A Helmy, I El Sayed, S Ghazal, S H Akhlagh, M Masjedi, K Hozhabri, E Kamali, I Zýková, B Paldusová, P Sedlák, D Morman, A M Youn, Y Ohta, M Sakuma, D Bates, T Morimoto, P L Su, W Y Chang, W C Lin, C W Chen, F Facchin, F Zarantonello, G Panciera, A De Cassai, A Venrdramin, A Ballin, T Tonetti, P Persona, C Ori, L Del Sorbo, S Rossi, G Vergani, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, T Tonetti, M Guanziroli, A Colombo, I Tomic, A Colombo, F Crimella, E Carlesso, V Gasparovic, L Gattinoni, A Serpa Neto, M Schmidt, T Pham, A Combes, M Gama de Abreu, P Pelosi, M J Schultz, B H Katira, D Engelberts, R E Giesinger, C Ackerley, T Yoshida, D Zabini, G Otulakowski, M Post, W M Kuebler, P J McNamara, B P Kavanagh, R Pirracchio, M Resche Rigon, M Carone, S Chevret, D Annane, S Eladawy, M El-Hamamsy, N Bazan, M Elgendy, G De Pascale, M S Vallecoccia, S L Cutuli, V Di Gravio, M A Pennisi, G Conti, M Antonelli, D T Andreis, W Khaliq, M Singer, J Hartmann, S Harm, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellán, J Veganzones Ramos, L Pérez Pérez, B Lobo Valbuena, N Martínez Sanz, I Fernández Simón, M Arrigo, E Feliot, N Deye, A Cariou, B Guidet, S Jaber, M Leone, M Resche-Rigon, A Vieillard Baron, M Legrand, E Gayat, A Mebazaa, M Balik, I Kolnikova, M Maly, P Waldauf, G Tavazzi, J Kristof, A Herpain, F Su, E Post, F Taccone, J L Vincent, J Creteur, C Lee, F Hatib, Z Jian, S Buddi, M Cannesson, S Fileković, M Turel, R Knafelj, V Gorjup, R Stanić, P Gradišek, O Cerović, T Mirković, M Noč, J Tirkkonen, H Hellevuo, K T Olkkola, S Hoppu, K C Lin, W T Hung, C C Chiang, W C Huang, W C Juan, S C Lin, C C Cheng, P H Lin, K Y Fong, D S Hou, P L Kang, S R Wann, Y S Chen, G Y Mar, C P Liu, M Paul, W Bougouin, G Geri, F Dumas, B Champigneulle, S Legriel, J Charpentier, J P Mira, C Sandroni, A Cariou, J Zimmerman, E Sullivan, M Noursadeghi, B Fox, D Sampson, L McHugh, T Yager, S Cermelli, T Seldon, S Bhide, R A Brandon, R B Brandon, J Zwaag, R Beunders, P Pickkers, M Kox, F Gul, M K Arslantas, D Genc, N Zibandah, L Topcu, T Akkoc, I Cinel, E Greco, M P Lauretta, D T Andreis, M Singer, I Palacios Garcia, M Cordero, A Diaz Martin, T Aldabó Pallás, J Garnacho Montero, J Revuelto Rey, L Roman Malo, A A Tanaka Montoya, A D C Amador Martinez, L Y Delgado Ayala, E Monares Zepeda, J Franco Granillo, J Aguirre Sanchez, G Camarena Alejo, A Rugerio Cabrera, A Pedraza Montenegro, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Soilemezi, E Koco, S Savvidou, C Nouris, D Matamis, R Di Mussi, S Spadaro, C A Volta, M Mariani, A Colaprico, C Antonio, F Bruno, S Grasso, A Rodriguez, I Martín-Loeches, E Díaz, J R Masclans, F Gordo, J Solé-Violán, M Bodí, F X Avilés-Jurado, S Trefler, M Magret, L F Reyes, J Marín-Corral, J C Yebenes, A Esteban, A Anzueto, S Aliberti, M I Restrepo, J Skytte Larsson, B Redfors, S E Ricksten, R Haines, J Powell-Tuck, H Leonard, M Ostermann, R E Berthelsen, T S Itenov, A Perner, J U Jensen, M Ibsen, A E K Jensen, M H Bestle, T Bucknall, J Dixon, F Boa, I MacPhee, B J Philips, J Doyle, F Saadat, T Samuels, S Huddart, B McCormick, R DeBrunnar, J Preece, M Swart, C Peden, S Richardson, L Forni, P Kalfon, K Baumstarck, P Estagnasie, M A Geantot, A Berric, G Simon, B Floccard, T Signouret, M Boucekine, M Fromentin, M Nyunga, A Sossou, M Venot, R Robert, A Follin, A Renault, M Garrouste, O Collange, Q Levrat, I Villard, D Thévenin, J Pottecher, R G Patrigeon, N Revel, C Vigne, O Mimoz, P Auquier, S Pawar, T Jacques, K Deshpande, R Pusapati, B Wood, R A Pulham, J Wray, K Brown, C Pierce, S Nadel, P Ramnarayan, J R Azevedo, W S Montenegro, D P Rodrigues, S C Sousa, V F Araujo, A L Leitao, P H Prazeres, A V Mendonca, M P Paula, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, A Lischinsky, M Veronesi, M Emmerich, E Descotte, A Juliarena, M Carboni Bisso, M Grando, A Tapia, M Camargo, D Villani Ulla, L Corzo, H Placido Dos Santos, A Ramos, J A Doglia, E Estenssoro, M Carbonara, S Magnoni, C L Mac Donald, J S Shimony, V Conte, F Triulzi, F Stretti, M Macrì, A Z Snyder, N Stocchetti, D L Brody, V Podlepich, V Shimanskiy, I Savin, K Lapteva, A Chumaev, M C Tjepkema-Cloostermans, J Hofmeijer, A Beishuizen, H Hom, M J Blans, M J A M van Putten, L Longhi, B Frigeni, M Curinga, D Mingone, S Beretta, A Patruno, L Gandini, A Vargiolu, F Ferri, R Ceriani, M R Rottoli, L Lorini, G Citerio, S Pifferi, M Battistini, V Cordolcini, A Agarossi, R Di Rosso, F Ortolano, N Stocchetti, C Mora Lourido, J L Santana Cabrera, J D Martín Santana, L Melián Alzola, C García Del Rosario, H Rodríguez Pérez, R Lorenzo Torrent, S Eslami, A Dalhuisen, T Fiks, M J Schultz, A Abu Hanna, P E Spronk, M Wood, D Maslove, J Muscedere, S H Scott, T Saha, A Hamilton, D Petsikas, D Payne, J G Boyd, Z A Puthucheary, A S McNelly, J Rawal, B Connolly, M J McPhail, P Sidhu, A Rowlerson, J Moxham, S D Harridge, N Hart, H E Montgomery, T Jovaisa, B Thomas, D Gupta, D S Wijayatilake, H P Shum, H S King, K C Chan, K B Tang, W W Yan, C Castro Arias, J Latorre, A Suárez De La Rica, E Maseda Garrido, A Montero Feijoo, C Hernández Gancedo, A López Tofiño, F Gilsanz Rodríguez, L K Gemmell, R Campbell, P Doherty, A MacKay, N Singh, S Vitaller, H Nagib, J Prieto, A Del Arco, B Zayas, C Gomez, S Tirumala, S A Pasha, B K Kumari, P Martinez-Lopez, A Puerto-Morlán, P Nuevo-Ortega, L Martinez Pujol, R Algarte Dolset, B Sánchez González, S Quintana Riera, J Trenado Álvarez, S Quintana, L Martínez, R Algarte, B Sánchez, J Trenado, E Tomas, N Brock, E Viegas, E Filipe, D Cottle, T Traynor, M V Trasmonte Martínez, M Pérez Márquez, L Colino Gómez, N Arias Martínez, J M Milicua Muñoz, B Quesada Bellver, M Muñoz Varea, M Á Alcalá Llorente, C Pérez Calvo, S D Hillier, M C Faulds, H Hendra, N Lawrence, K Maekawa, M Hayakawa, Y Ono, A Kodate, Y Sadamoto, N Tominaga, A Mizugaki, H Murakami, T Yoshida, K Katabami, T Wada, A Sawamura, S Gando, S Silva, L Kerhuel, B Malagurski, G Citerio, R Chabanne, S Laureys, L Puybasset, L Nobile, E R Pognuz, A O Rossetti, F Verginella, N Gaspard, J Creteur, N Ben-Hamouda, M Oddo, F S Taccone, Y Ono, M Hayakawa, H Iijima, K Maekawa, A Kodate, Y Sadamoto, A Mizugaki, H Murakami, K Katabami, T Wada, A Sawamura, S Gando, A Kodate, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, L W Andersen, T Raymond, R Berg, V Nadkarni, A Grossestreuer, T Kurth, M Donnino, A Krüger, P Ostadal, M Janotka, D Vondrakova, N Kongpolprom, J Cholkraisuwat, P T Pekkarinen, G Ristagno, S Masson, R Latini, S Bendel, T Ala-Kokko, T Varpula, J Vaahersalo, S Hoppu, M Tiainen, M M Mion, M Plebani, V Pettilä, M B Skrifvars, Y Son, K S Kim, G J Suh, W Y Kwon, J I Ko, M J Park, F Zama Cavicchi, E Iesu, L Nobile, J L Vincent, J Creteur, F S Taccone, H Tanaka, N Otani, S Ode, S Ishimatsu, L Martínez, R Algarte, B Sánchez, I Romero, F Martínez, S Quintana, J Trenado, D Vondrakova, P Ostadal, A Kruger, M Janotka, F Malek, P Neuzil, Y C Yeh, Y S Chen, C H Wang, C H Huang, A Chao, C T Lee, C H Lai, W S Chan, Y J Cheng, W Z Sun, S Kaese, C Horstmann, P Lebiedz, M Mourad, P Gaudard, J Eliet, N Zeroual, P Colson, P Ostadal, M Mlcek, M Hrachovina, A Kruger, D Vondrakova, M Janotka, M Mates, P Hala, O Kittnar, P Neuzil, A Jacky, A Rudiger, D R Spahn, D A Bettex, A Kara, S Akin, D Dos Reis Miranda, A Struijs, K Caliskan, R J van Thiel, E A Dubois, W de Wilde, F Zijlstra, D Gommers, C Ince, L Marca, A Xini, W Mongkolpun, C P R Cordeiro, R T Leite, O Lheureux, A Bader, L Rincon, C Santacruz, J C Preiser, A Chao, A S Chao, Y S Chen, W Kim, C Ahn, Y Cho, T H Lim, J Oh, K S Choi, B H Jang, J K Ha, A Mecklenburg, J Stamm, G Soeffker, M Kubik, K Sydow, H Reichenspurner, S Kluge, S Braune, B Bergantino, F Ruberto, E Magnanimi, E Privato, V Zullino, K Bruno, F Pugliese, G Sales, V Girotto, F Vittone, L Brazzi, C Fritz, A Kimmoun, F Vanhuyse, B Trifan, S Orlowski, E Albuisson, N Tran, B Levy, V Chhor, J Joachim, A Follin, B Champigneulle, J Chatelon, G Fave, J Mantz, R Pirracchio, D Díaz Diaz, M Villanova, M Aguirregabyria, G Andrade, L López, E Palencia, G John, R Cowan, R Hart, K Lake, K Litchfield, J W Song, Y J Lee, Y J Cho, S Choi, P Vermeir, D Vandijck, S Blot, A Mariman, R Verhaeghe, M Deveugele, D Vogelaers, L Chok, E B Bachli, D Bettex, S R Cottini, E Keller, M Maggiorini, R Schuepbach, T Fiks, C Stiphout, M Grevelink, I Vaneker, A Ruijter, M Buise, P E Spronk, S Altaba Tena, L Galarza Barrachina, J H Rodriguez Portillo, G Pagés Aznar, L Mateu Campos, M D Ferrándiz Sellés, M Arlandis Tomás, A Belenguer Muncharaz, L Skinner, S Monsalvo, E Olavarria, R Stümpfle, S J Na, J Park, C R Chung, C M Park, G Y Suh, J H Yang, T Witter, C Brousseau, M B Butler, M Erdogan, P C Mac Dougall, R S Green, T E F Abbott, H D T Torrance, N Cron, N Vaid, J Emmanuel, S S Siddiqui, N Prabu, H K Chaudhari, V P Patil, J V Divatia, S Solanki, A P Kulkarni, L A Rincon Gutierrez, A Bader, A Brasseur, O Lheureux, J L Vincent, J Creteur, F S Taccone, D Hempel, N Stauffert, F Recker, T Schröder, S Reusch, J Schleifer, R Breitkreutz, F Sjövall, A Perner, M Hylander Møller, R B Moraes, F K Borges, J A V Guillen, W J C Zabaletta, J Ruiz-Ramos, P Ramirez, M R Marqués-Miñana, E Villarreal, M Gordon, M Sosa, P Concha, A Castellanos, R Menendez, C Sánchez Ramírez, M Cabrera Santana, L Caipe Balcázar, S Hípola Escalada, M A Hernández Viera, C F Lübbe Vázquez, J J Díaz Díaz, F Artiles 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Pont, A Kotsopoulos, N Jansen, W F Abdo, A Gopcevic, Z Gavranovic, M Vucic, M Zlatic Glogoski, L Videc Penavic, A Horvat, L Martin-Villen, J J Egea-Guerero, J Revuelto-Rey, T Aldabo-Pallas, E Correa-Chamorro, A I Gallego-Corpa, P Ruiz Del Portal-Ruiz Granados, V Faivre, L Wildenberg, B Huot, A C Lukaszewicz, M Simsir, C Mengelle, D Payen, N Martinez Sanz, B Lobo Valbuena, M Valdivia de la Fuente, P Matía Almudena, L Pérez Pérez, S Alcántara Carmona, A Navarro Abellán, I Fernández Simón, J J Rubio Muñoz, J Veganzones Ramos, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellan, M A Perez Lucendo, L Perez Perez, J Palamidessi Dominguez, R Fernandez Rivas, P Rodriguez Villamizar, S Wee, C Ong, Y H Lau, Y Wong, M E Banderas-Bravo, V Olea-Jiménez, J M Mora-Ordóñez, C Gómez-Jiménez, J L Muñoz-Muñoz, J Vallejo-Báez, D Daga-Ruiz, M Lebrón-Gallardo, G Rialp, J M Raurich, I Morán, M C Martín, G Heras, A Mas, I Vallverdú, S Hraiech, J Bourenne, C Guervilly, J M Forel, M Adda, P Sylla, A Mouaci, M Gainnier, L Papazian, P R Bauer, A Kumbamu, M E Wilson, J K Pannu, J S Egginton, R Kashyap, O Gajic, S Yoshihiro, M Sakuraya, M Hayakawa, A Hirata, N Kawamura, T Tsutui, K Yoshida, Y Hashimoto, C H Chang, H C Hu, L C Chiu, C Y Hung, S H Li, K C Kao, S Sibley, J Drover, C D'Arsigny, C Parker, D Howes, S Moffatt, J Erb, R Ilan, D Messenger, I Ball, J G Boyd, M Harrison, S Ridi, J Muscedere, A H Andrade, R C Costa, V A Souza, V Gonzalez, V Amorim, F Rolla, C A C Abreu Filho, R Miranda, S Atchasiri, P Buranavanich, T Wathanawatthu, S Suwanpasu, C Bureau, C Rolland-Debord, T Poitou, M Clavel, S Perbet, N Terzi, A Kouatchet, T Similowski, A Demoule, P Diaz, J Nunes, S Escórcio, G Silva, S Chaves, M Jardim, M Câmara, N Fernandes, R Duarte, J J Jardim, C A Pereira, J J Nóbrega, C M Chen, C C Lai, K C Cheng, W Chou, S J Lee, Y S Cha, W Y Lee, M Onodera, E Nakataki, J Oto, H Imanaka, M Nishimura, A Khadjibaev, D Sabirov, A Rosstalnaya, R Akalaev, F Parpibaev, E Antonucci, P Rossini, S Gandolfi, E Montini, S Orlando, M van Nes, F Karachi, S Hanekom, A H Andrade, U V Pereira, C A C Abreu Filho, R C Costa, M S W Parkin, M Moore, A H Andrade, R C Costa, K V Silva Carvalho, C A C Abreu Filho, H J Min, H J Kim, D S Lee, Y Y Choi, E Y Lee, I Song, D J Kim, Y Y E, J W Kim, J S Park, Y J Cho, J H Lee, J W Suh, Y H Jo, K S Kim, Y J Lee, J Ferrero-Calleja, D Merino-Vega, A I González-Jiménez, M Sigcha Sigcha, A Hernández-Tejedor, A Martin-Vivas, Á Gabán-Díez, R Ruiz-de Luna, N De la Calle-Pedrosa, I Temprano-Gómez, D Afonso-Rivero, J I Pellin-Ariño, A Algora-Weber, R R L Fumis, A B Ferraz, J M Vieira Junior, H Kirca, O Cakin, M Unal, H Mutlu, A Ramazanoglu, M Cengiz, E A Nicolini, F G F Pelisson, R S Nunes, S L da Silva, M M Carreira, F Bellissimo-Rodrigues, M A Ferez, A Basile-Filho, H C Chao, C M Chen, L Chen, M Hravnak, G Clermont, M Pinsky, A Dubrawski, J Luján Varas, R Molina Montero, L Alcázar Sánchez-Elvira, P Villa Díaz, C Pintado Delgado, B Llorente Ruiz, A Pardo 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No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27676247/a-novel-approach-to-proactive-primary-care-based-case-finding-and-multidisciplinary-management-of-falls-syncope-and-dizziness-in-a-one-stop-service-preliminary-results
#5
Steve W Parry, Harry Hill, Joanna Lawson, Nick Lawson, David Green, Heidi Trundle, Judith McNaught, Victoria Strassheim, Alma Caldwell, Richard Mayland, Phillip Earley, Peter McMeekin
National and international evidence and guidelines on falls prevention and management in community-dwelling elderly adults recommend that falls services should be multifactorial and their interventions multicomponent. The way that individuals are identified as having had or being at risk of falls in order to take advantage of such services is far less clear. A novel multidisciplinary, multifactorial falls, syncope, and dizziness service model was designed with enhanced case ascertainment through proactive, primary care-based screening (of individual case notes of individuals aged ≥60) for individual fall risk factors...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27661864/point-prevalence-study-of-mobilization-practices-for-acute-respiratory-failure-patients-in-the-united-states
#6
Sarah Elizabeth Jolley, Marc Moss, Dale M Needham, Ellen Caldwell, Peter E Morris, Russell R Miller, Nancy Ringwood, Megan Anders, Karen K Koo, Stephanie E Gundel, Selina M Parry, Catherine L Hough
OBJECTIVE: Early mobility in mechanically ventilated patients is safe, feasible, and may improve functional outcomes. We sought to determine the prevalence and character of mobility for ICU patients with acute respiratory failure in U.S. ICUs. DESIGN: Two-day cross-sectional point prevalence study. SETTING: Forty-two ICUs across 17 Acute Respiratory Distress Syndrome Network hospitals. PATIENTS: Adult patients (≥ 18 yr old) with acute respiratory failure requiring mechanical ventilation...
September 22, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27625317/scan_tcga-tools-for-integrated-epigenomic-and-transcriptomic-analysis-of-tumor-subgroups
#7
Aniruddha Chatterjee, Peter A Stockwell, Euan J Rodger, Matthew F Parry, Michael R Eccles
AIM: The Cancer Genome Atlas contains multiple levels of genomic data (mutation, gene expression, DNA methylation, copy number variation) for 33 cancer types for almost 11,000 patients. However, a dearth of appropriate software tools makes it difficult for bench scientists to use these data effectively. MATERIALS & METHODS: Here, we present a suite of flexible, fast and command line-based scripts that will allow retrieval and analysis of DNA methylation (tool: scan_tcga_methylation...
October 2016: Epigenomics
https://www.readbyqxmd.com/read/27625211/beyond-cdr-grafting-structure-guided-humanization-of-framework-and-cdr-regions-of-an-anti-myostatin-antibody
#8
James R Apgar, Michelle Mader, Rita Agostinelli, Susan Benard, Peter Bialek, Mark Johnson, Yijie Gao, Mark Krebs, Jane Owens, Kevin Parris, Michael St Andre, Kris Svenson, Carl Morris, Lioudmila Tchistiakova
Antibodies are an important class of biotherapeutics that offer specificity to their antigen, long half-life, effector function interaction and good manufacturability. The immunogenicity of non-human-derived antibodies, which can be a major limitation to development, has been partially overcome by humanization through complementarity-determining region (CDR) grafting onto human acceptor frameworks. The retention of foreign content in the CDR regions, however, is still a potential immunogenic liability. Here, we describe the humanization of an anti-myostatin antibody utilizing a 2-step process of traditional CDR-grafting onto a human acceptor framework, followed by a structure-guided approach to further reduce the murine content of CDR-grafted antibodies...
October 2016: MAbs
https://www.readbyqxmd.com/read/27468772/introduction-priority-setting-equitable-access-and-public-involvement-in-health-care
#9
Albert Weale, Katharina Kieslich, Peter Littlejohns, Aviva Tugendhaft, Emma Tumilty, Krisantha Weerasuriya, Jennifer A Whitty
Purpose - The purpose of this paper is to introduce the special issue on improving equitable access to health care through increased public and patient involvement (PPI) in prioritization decisions by discussing the conceptualization, scope and rationales of PPI in priority setting that inform the special issue. Design/methodology/approach - The paper employs a mixed-methods approach in that it provides a literature review and a conceptual discussion of the common themes emerging in the field of PPI and health priority setting...
August 15, 2016: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/27447437/situational-awareness-what-it-means-for-clinicians-its-recognition-and-importance-in-patient-safety
#10
Ben Green, David Parry, Rachel S Oeppen, Simon Plint, Trevor Dale, Peter A Brennan
A thorough understanding of the role of human factors in error in health care for improving patient safely is paramount. One area particularly crucial for optimising clinical performance is the recognising the importance of situational awareness. Loss of situation awareness can occur in many different settings, particularly during stressful and unexpected situations. Tunnel vision is a classic example where clinicians focus on one aspect of care, often to the detriment of overall patient management. Loss of situational awareness can result in serious compromise to patient safety if it is not recognised by either the individual or clinical team...
July 22, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27367766/standardized-rehabilitation-and-hospital-length-of-stay-among-patients-with-acute-respiratory-failure-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Peter E Morris, Michael J Berry, D Clark Files, J Clifton Thompson, Jordan Hauser, Lori Flores, Sanjay Dhar, Elizabeth Chmelo, James Lovato, L Douglas Case, Rita N Bakhru, Aarti Sarwal, Selina M Parry, Pamela Campbell, Arthur Mote, Chris Winkelman, Robert D Hite, Barbara Nicklas, Arjun Chatterjee, Michael P Young
IMPORTANCE: Physical rehabilitation in the intensive care unit (ICU) may improve the outcomes of patients with acute respiratory failure. OBJECTIVE: To compare standardized rehabilitation therapy (SRT) to usual ICU care in acute respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Single-center, randomized clinical trial at Wake Forest Baptist Medical Center, North Carolina. Adult patients (mean age, 58 years; women, 55%) admitted to the ICU with acute respiratory failure requiring mechanical ventilation were randomized to SRT (n=150) or usual care (n=150) from October 2009 through May 2014 with 6-month follow-up...
June 28, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27346599/corrigendum-solar-cycles-or-random-processes-evaluating-solar-variability-in-holocene-climate-records
#12
T Edward Turner, Graeme T Swindles, Dan J Charman, Peter G Langdon, Paul J Morris, Robert K Booth, Lauren E Parry, Jonathan E Nichols
No abstract text is available yet for this article.
2016: Scientific Reports
https://www.readbyqxmd.com/read/27340294/the-epsrc-s-policy-of-responsible-innovation-from-a-trading-zones-perspective
#13
Joseph Murphy, Sarah Parry, John Walls
Responsible innovation (RI) is gathering momentum as an academic and policy debate linking science and society. Advocates of RI in research policy argue that scientific research should be opened up at an early stage so that many actors and issues can steer innovation trajectories. If this is done, they suggest, new technologies will be more responsible in different ways, better aligned with what society wants, and mistakes of the past will be avoided. This paper analyses the dynamics of RI in policy and practice and makes recommendations for future development...
2016: Minerva
https://www.readbyqxmd.com/read/27311525/aortic-valve-replacement-and-the-ross-operation-in-children-and%C3%A2-young-adults
#14
Mansour T A Sharabiani, Dan M Dorobantu, Alireza S Mahani, Mark Turner, Andrew J Peter Tometzki, Gianni D Angelini, Andrew J Parry, Massimo Caputo, Serban C Stoica
BACKGROUND: There are several options available for aortic valve replacement (AVR), with few comparative reports in the literature. The optimal choice for AVR in each age group is not clear. OBJECTIVES: The study sought to report and compare outcomes after AVR in the young using data from a national database. METHODS: AVR procedures were compared after advanced matching, both in pairs and in a 3-way manner, using a Bayesian dynamic survival model...
June 21, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27213426/a-new-orbivirus-isolated-from-mosquitoes-in-north-western-australia-shows-antigenic-and-genetic-similarity-to-corriparta-virus-but-does-not-replicate-in-vertebrate-cells
#15
Jessica J Harrison, David Warrilow, Breeanna J McLean, Daniel Watterson, Caitlin A O'Brien, Agathe M G Colmant, Cheryl A Johansen, Ross T Barnard, Sonja Hall-Mendelin, Steven S Davis, Roy A Hall, Jody Hobson-Peters
The discovery and characterisation of new mosquito-borne viruses provides valuable information on the biodiversity of vector-borne viruses and important insights into their evolution. In this study, a broad-spectrum virus screening system, based on the detection of long double-stranded RNA in inoculated cell cultures, was used to investigate the presence of novel viruses in mosquito populations of northern Australia. We detected and isolated a new virus (tentatively named Parry's Lagoon virus, PLV) from Culex annulirostris, Culex pullus, Mansonia uniformis and Aedes normanensis mosquitoes that shares genomic sequence similarities to Corriparta virus (CORV), a member of the Orbivirus genus of the family Reoviridae...
2016: Viruses
https://www.readbyqxmd.com/read/27172225/placental-hypomethylation-is-more-pronounced-in-genomic-loci-devoid-of-retroelements
#16
Aniruddha Chatterjee, Erin C Macaulay, Euan J Rodger, Peter A Stockwell, Matthew F Parry, Hester E Roberts, Tania L Slatter, Noelyn A Hung, Celia J Devenish, Ian M Morison
The human placenta is hypomethylated compared to somatic tissues. However, the degree and specificity of placental hypomethylation across the genome is unclear. We assessed genome-wide methylation of the human placenta and compared it to that of the neutrophil, a representative homogeneous somatic cell. We observed global hypomethylation in placenta (relative reduction of 22%) compared to neutrophils. Placental hypomethylation was pronounced in intergenic regions and gene bodies, while the unmethylated state of the promoter remained conserved in both tissues...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27045989/solar-cycles-or-random-processes-evaluating-solar-variability-in-holocene-climate-records
#17
T Edward Turner, Graeme T Swindles, Dan J Charman, Peter G Langdon, Paul J Morris, Robert K Booth, Lauren E Parry, Jonathan E Nichols
Many studies have reported evidence for solar-forcing of Holocene climate change across a range of archives. These studies have compared proxy-climate data with records of solar variability (e.g. (14)C or (10)Be), or have used time series analysis to test for the presence of solar-type cycles. This has led to some climate sceptics misrepresenting this literature to argue strongly that solar variability drove the rapid global temperature increase of the twentieth century. As proxy records underpin our understanding of the long-term processes governing climate, they need to be evaluated thoroughly...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26928983/investigating-the-experiences-of-childhood-cancer-patients-and-parents-participating-in-optional-nontherapeutic-clinical-research-studies-in-the-uk
#18
Julie Errington, Ghada Malik, Julie Evans, Jenny Baston, Annie Parry, Lisa Price, Hina Johnstone, Selena Peters, Victoria Oram, Karen Howe, Emma Whiteley, Jane Tunnacliffe, Gareth J Veal
BACKGROUND: While the majority of childhood cancer clinical trials are treatment related, additional optional research investigations may be carried out that do not directly impact on treatment. It is essential that these studies are conducted ethically and that the experiences of families participating in these studies are as positive as possible. METHODS: A questionnaire study was carried out to investigate the key factors that influence why families choose to participate in optional nontherapeutic research studies, the level of understanding of the trials involved, and the experiences of participation...
July 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26795897/hydrogen-bond-accepting-properties-of-new-heteroaromatic-ring-chemical-motifs-a-theoretical-study
#19
Jérôme Graton, Jean-Yves Le Questel, Peter Maxwell, Paul Popelier
UNLABELLED: The prediction of hydrogen-bond (H-bond) acceptor ability is crucial in drug design. This important property is quantified in a large pKBHX database of consistently measured values. We aim to expand the chemical diversity of the studied H-bond acceptors and to increase the range of H-bond strength considered. Two quantum chemical descriptors are contrasted, called ΔE(H) (the change in the energy of a topological hydrogen atom upon complexation) and Vmin (the local minimum in the electrostatic potential on the H-bond accepting site)...
February 22, 2016: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/26732125/evaluation-of-serum-markers-in-the-lrf-cll4-trial-%C3%AE-2-microglobulin-but-not-serum-free-light-chains-is-an-independent-marker-of-overall-survival
#20
Guy Pratt, Peter Thomas, Nicola Marden, Denis Alexander, Zadie Davis, David Hussey, Helen Parry, Stephen Harding, Daniel Catovsky, Joe Begley, David Oscier
Chronic lymphocytic leukemia (CLL) is characterized by heterogeneous clinical behavior and there is a need for improved biomarkers. The current study evaluated the prognostic significance of serum free light chains (sFLC, kappa, and lambda) and other serum markers (bar, serum thymidine kinase (sTK), soluble CD23, and LDH) together with established biomarkers in 289 patients enrolled into the LRF CLL4 trial. In a multivariable analysis of serum markers alone, higher big and kappa light chains were statistically significant in predicting disease progression and higher blg, and sTK in predicting mortality...
October 2016: Leukemia & Lymphoma
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