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https://www.readbyqxmd.com/read/29146066/immunological-response-induced-by-cryoablation-against-murine-h22-hepatoma-cell-line-in-vivo
#1
Xueling Yang, Xiaoli Li, Zhi Guo, Tongguo Si, Haipeng Yu, Wenge Xing
OBJECTIVES: To describe immunological consequences induced by cryoablation against H22 cells in vivo. METHODS: Adult BALB/c mice underwent subcutaneous implantation of H22 cells. All of them were assigned into three groups randomly: group A (false surgery), group B (cryoablation) and group C (cryoablation plus Freund's adjuvant). Animals were sacrificed 1, 2 and 3 weeks after treatment. Serum IFN-γ and IL-4, Th1/Th2 in spleens and cytotoxicity were detected. RESULTS: Compared with that of group A, (1) INF-γ of group B was higher, but IL-4 was lower; cryoablation plus Freund's adjuvant enhanced these effects...
November 13, 2017: Cryobiology
https://www.readbyqxmd.com/read/29145161/cyp450-enzyme-specific-enantioselective-species-specific-response-for-metalaxyl-in-in-vitro-hepatic-cells
#2
Wei Xie, Fangxing Yang
Although enantioselective accumulation of chiral pesticide has been reported in organisms, the mechanisms remain unclear. In this study, the effects of chiral pesticide metalaxyl on CYP1A1, CYP1A2, CYP2B1, CYP2B2, CYP2E1 and CYP3A were investigated in human hepatoma HepG2, rat hepatic H4IIE, chicken hepatic LMH and grass carp hepatic L8824 cells. Moreover, the residual concentrations and enantiomeric ratios (ERs) of metalaxyl were also detected in the medium. The results showed the responses of these CYP450s to metalaxyl were enzyme-dependent and species-dependent in the four cells...
November 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29138336/correction-for-dixit-et-al-fuse-binding-protein-1-facilitates-persistent-hepatitis-c-virus-replication-in-hepatoma-cells-by-regulating-tumor-suppressor-p53
#3
Updesh Dixit, Ashutosh K Pandey, Zhihe Liu, Sushil Kumar, Matthew B Neiditch, Kenneth M Klein, Virendra N Pandey
No abstract text is available yet for this article.
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29137114/natural-cyclopeptide-ra-xii-a-new-autophagy-inhibitor-suppresses-protective-autophagy-for-enhancing-apoptosis-through-ampk-mtor-p70s6k-pathways-in-hepg2-cells
#4
Lihua Song, Zhe Wang, Yurong Wang, Di Guo, Jianhong Yang, Lijuan Chen, Ninghua Tan
Liver cancer is a progressive, irreversible and aggressive malignant disease, which has no effective chemotherapeutic drugs. RA-XII, a natural cyclopeptide isolated from the traditional Chinese medicine Rubia yunnanensis, exerts anti-cancer and anti-inflammatory activities. This work aimed to investigate the effects of RA-XII on a hepatic tumor and its underlying mechanisms in human hepatoma HepG2 cells. The results showed that RA-XII effectively inhibited the proliferation of HepG2 cells. Consistently, RA-XII significantly induced apoptosis in HepG2 cells by decreasing the expression of caspase 3, 8, 9, and promoting the Cleavage of PARP...
November 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29132372/hepatitis-b-virus-inhibits-the-in-vivo-and-in-vitro-synthesis-and-secretion-of-apolipoprotein-c3
#5
Chengliang Zhu, Hengcheng Zhu, Hui Song, Limin Xu, Longxuan Li, Fang Liu, Xinghui Liu
BACKGROUND: Hepatitis B virus (HBV) infection in the body can damage liver cells and cause disorders in blood lipid metabolism. Apolipoprotein C3 (ApoC3) plays an important role in the regulation of lipid metabolism, but no study on the HBV regulation of ApoC3 has been reported. This purpose of this study was to investigate the effect of HBV on ApoC3 expression and its regulatory mechanism. METHODS: The expression levels of ApoC3 mRNA and protein in the human hepatoma cell lines HepG2 and HepG2...
November 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29131381/long-non-coding-rna-cox-2-prevents-immune-evasion-and-metastasis-of-hepatocellular-carcinoma-by-altering-m1-m2-macrophage-polarization
#6
Yibiao Ye, Yunxiuxiu Xu, Yu Lai, Wenguang He, Yanshan Li, Ruomei Wang, Xinxi Luo, Xinxi Luo, Rufu Chen, Tao Chen
OBJECTIVE: Macrophages have been shown to demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. We investigate long non-coding RNA (lncRNA) cox-2 in macrophage polarization and the regulatory mechanism functions in hepatocellular carcinoma (HCC). METHODS: Lipopolysaccharide (LPS) was used to induce RAW264.7 macrophages into M1 type, and IL-4 was to induce RAW264.7 macrophages into M2 type. We selected mouse hepatic cell line Hepal-6 and hepatoma cell line HepG2 for co-incubation with M1 or M2 macrophages...
November 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29128601/isolation-modification-and-cytotoxic-evaluation-of-stilbenoids-from-acanthopanax-leucorrhizus
#7
Hao-Bin Hu, Hai-Peng Liang, Hai-Ming Li, Ru-Nan Yuan, Jiao Sun, La-La Zhang, Ming-Hu Han, Yun Wu
Twenty natural stilbenoids (1-20), including seven new stilbenoids (2, 4-7, 19, 20) and thirteen known stilbenoids (1, 3, 8-18), were isolated from the stem barks of Acanthopanax leucorrhizus, and six modified stilbenoid derivatives (1a, 2a, 4a, 4b, 7a and 17a) were obtained via methylation, demethylation and isopentenylation of the corresponding isolates (1, 2, 4, 7 and 17). These stilbenoids were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (leukemia HL-60, hepatoma SMMC-7721 and breast carcinoma MCF-7) in vitro by MTT assay...
November 8, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29126901/omega-3-polyunsaturated-fatty-acids-protect-human-hepatoma-cells-from-developing-steatosis-through-ffa4-gpr120
#8
Saeromi Kang, Jin Huang, Bo-Kyung Lee, Young-Suk Jung, Eunok Im, Jung-Min Koh, Dong-Soon Im
Protective effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-alcoholic fatty liver disease has been demonstrated. FFA4 (also known as GPR120; a G protein-coupled receptor) has been suggested to be a target of n-3 PUFA. FFA4 expression in hepatocytes has also been reported from liver biopsies in child fatty liver patients. In order to assess the functional role of FFA4 in hepatic steatosis, we used an in vitro model of liver X receptor (LXR)-mediated hepatocellular steatosis. FFA4 expression was confirmed in Hep3B and HepG2 human hepatoma cells...
November 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29123482/anticancer-activities-of-surfactin-and-potential-application-of-nanotechnology-assisted-surfactin-delivery
#9
REVIEW
Yuan-Seng Wu, Siew-Ching Ngai, Bey-Hing Goh, Kok-Gan Chan, Learn-Han Lee, Lay-Hong Chuah
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis, and metastasis arrest. Owing to the potent effect of surfactin on cancer cells, numerous studies have recently investigated the mechanisms that underlie its anticancer activity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29122633/iridoids-and-sfingolipids-from-hedyotis-diffusa
#10
Changfu Wang, Ping Xin, Youzhi Wang, Xuegang Zhou, Donghua Wei, Chengjie Deng, Shiqin Sun
Seven new compounds were isolated from the aerial part of Hedyotis diffusa, including three iridoid glycosides, hedyoiridoidside A - C (1-3), two cerebrosides, hedyocerenoside F (4) and G (5), and two new ceramides, hedyoceramide A (6) and B (7). And six known iridoid glycosides (8-13) were also obtained. Their structures were established by their physico-chemical constants and spectroscopic analysis. The cytotoxicity of all compounds against tumor cell lines of human cervical cancer HeLa, human leukemia HL-60, human lung cancer A459, human hepatoma HepG2, human gastric gland carcinoma BCG-823, human nasopharyngeal cancer CNE-2, human colon cancer HCT15, and human prostate cancer PC-3 were also evaluated in vitro...
November 6, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29122364/photocatalytic-degradation-of-4-amino-6-chlorobenzene-1-3-disulfonamide-stable-hydrolysis-product-of-hydrochlorothiazide-detection-of-intermediates-and-their-toxicity
#11
Sanja J Armaković, Stevan Armaković, Dragana D Četojević-Simin, Filip Šibul, Biljana F Abramović
In this work we have investigated in details the process of degradation of the 4-amino-6-chlorobenzene-1,3-disulfonamide (ABSA), stable hydrolysis product of frequently used pharmaceutical hydrochlorothiazide (HCTZ), as one of the most ubiquitous contaminants in the sewage water. The study encompassed investigation of degradation by hydrolysis, photolysis, and photocatalysis employing commercially available TiO2 Degussa P25 catalyst. The process of direct photolysis and photocatalytic degradation were investigated under different type of lights...
November 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29118189/the-peptidyl-prolyl-isomerase-pin1-relieves-cyclin-dependent-kinase-2-cdk2-inhibition-by-the-cdk-inhibitor-p27
#12
Chi-Wai Cheng, Ka-Wai Leong, Yiu-Ming Ng, Yok-Lam Kwong, Eric Tse
PIN1 is a peptidyl-prolyl-isomerase that catalyzes the cis/trans isomerization of peptide bonds between proline and phosphorylated serine/threonine residues. By changing the conformation of its protein substrates, PIN1 increases the activities of key proteins that promote cell cycle progression and oncogenesis. Moreover, it has been shown that PIN1 stabilizes and increases the level of the cyclin-dependent kinase (CDK) inhibitor p27, which inhibits cell cycle progression by binding cyclin A- and cyclin E-CDK2...
November 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29115974/stat3-blocked-whole-cell-hepatoma-vaccine-induces-cellular-and-humoral-immune-response-against-hcc
#13
Qiuju Han, Yaqun Wang, Min Pang, Jian Zhang
BACKGROUND: Whole-cell tumor vaccines have shown much promise; however, only limited success has been achieved for the goal of eliciting robust tumor-specific T-cell responses. METHODS: Hepatocellular carcinoma (HCC) cells, H22 and Hepa1-6, were modified by blocking the STAT3 signaling pathway with a STAT3 decoy oligodeoxynucleotide, and the immunogenicity and possibility of using these cell lysates as a vaccine were evaluated. RESULTS: STAT3-blocked whole HCC cell lysates inhibited tumor growth and tumorigenesis, and prolonged the survival of tumor-bearing mice...
November 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29113334/exosomal-mir-665-as-a-novel-minimally-invasive-biomarker-for-hepatocellular-carcinoma-diagnosis-and-prognosis
#14
Zhen Qu, Junhua Wu, Junyi Wu, Anlai Ji, Guanghui Qiang, Yong Jiang, Chunping Jiang, Yitao Ding
Recent studies have shown that circulating microRNAs are potential biomarkers for various types of malignancies. The aim of this study was to investigate the feasibility of using serum exosomal microRNAs (miRNAs) as novel serological biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis. Exosomes are small membranous vesicles (30-100 nm). Exosomal miR-665 levels in HCC patients were significantly higher than those in healthy subjects (P < 0.05), and exosomal miR-665 levels were significantly upregulated in tumours larger in size (> 5 cm), in tumours with local invasion and in those at an advanced clinical stage (stage III/IV) of HCC (P = 0...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113258/combination-of-calcineurin-b-subunit-cnb-and-5-fluorouracil-reverses-5-fluorouracil-induced-immunosuppressive-effect-and-enhances-the-antitumor-activity-in-hepatocellular-carcinoma
#15
Wenlong Zhang, Youxiu Zhong, Hongfei Cui, Liya Wang, Rui Yang, Zhenyi Su, Benqiong Xiang, Qun Wei
Five-fluorouracil (5-FU) is a widely used chemotherapeutic agent for digestive system tumors; however, continuous use of 5-FU may cause severe side effects, including myelosuppression and immunosuppression. Our previous study revealed that calcineurin B subunit (CnB), an innovative genetic engineering antitumor protein, possesses tumor-suppressive effects with low toxicity. CnB can bind to and activate integrin αM on macrophages, subsequently promoting the expression, and secretion of TNF-related apoptosis-inducing ligand, a specific proapoptotic cytokine...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113144/modulation-of-cell-death-pathways-by-hepatitis-c-virus-proteins-in-huh7-5-hepatoma-cells
#16
Olga V Masalova, Ekaterina I Lesnova, Pavel N Solyev, Natalia F Zakirova, Vladimir S Prassolov, Sergey N Kochetkov, Alexander V Ivanov, Alla A Kushch
The hepatitis C virus (HCV) causes chronic liver disease leading to fibrosis, cirrhosis, and hepatocellular carcinoma. HCV infection triggers various types of cell death which contribute to hepatitis C pathogenesis. However, much is still unknown about the impact of viral proteins on them. Here we present the results of simultaneous immunocytochemical analysis of markers of apoptosis, autophagy, and necrosis in Huh7.5 cells expressing individual HCV proteins or their combinations, or harboring the virus replicon...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29111682/monitoring-membrane-lipidome-turnover-by-metabolic-15-n-labeling-and-shotgun-ultra-high-resolution-orbitrap-ft-ms
#17
Kai Schuhmann, Kristina Srzentić, Konstantin O Nagornov, Henrik Thomas, Theresia Gutmann, Ünal Coskun, Yury O Tsybin, Andrej Shevchenko
Lipidomes undergo permanent extensive re-modelling, but how the turnover rate differs between lipid classes and molecular species is poorly understood. We employed metabolic (15)N-labeling and shotgun ultra-high resolution mass spectrometry (sUHR) to quantify the absolute (molar) abundance and determine the turnover rate of glycerophospho- and sphingolipids by the direct analysis of total lipid extracts. sUHR performed on a commercial Orbitrap Elite instrument at the mass resolution of 1.35×10(6) (m/z200) baseline resolved peaks of (13)C isotopes of unlabeled and monoisotopic peaks of (15)N-labeled lipids (Δm = 0...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29108283/combination-of-sorafenib-and-tace-inhibits-portal-vein-invasion-for-intermediate-stage-hcc-a-single-center-retrospective-controlled-study
#18
Qi Yao, Hongsen Zhang, Bin Xiong, Chuansheng Zheng
Purpose: This study aims to investigate the effect of sorafenib plus Transarterial Chemoembolization (TACE) treatment on inhibiting portal vein invasion in patients with intermediate stage HCC. Materials and Methods: The consecutive medical records of patients with HCC were retrospectively analyzed from October 2009 to February 2015. The propensity score matching method was applied into group matching. The Kaplan-Meier method and the Log-Rank Test was used to estimate the median survival time, median time to progression and median time to portal vein invasion...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29106686/the-identification-of-pivotal-transcriptional-factors-mediating-cell-responses-to-drugs-with-drug-induced-liver-injury-liabilities
#19
Falgun Shah, Alex Medvedev, Anne Mai Wassermann, Marian Brodney, Liying Zhang, Sergei Makarov, Robert V Stanton
Drug-induced liver injury (DILI) is a leading cause of drug attrition during drug development and a common reason for drug withdrawal from the market. The poor predictability of conventional animal-based approaches (Olson et al. 2000) necessitates the development of alternative testing approaches. Body of evidence associates DILI with the induction of stress-response genes in the liver cells (Yuan and Kaplowitz 2013). Here, we set out to identify signal transduction pathways predominantly involved in the regulation of gene transcription by DILI drugs...
November 2, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29106433/codelivery-of-sorafenib-and-gpc3-sirna-with-pei-modified-liposomes-for-hepatoma-therapy
#20
Weitong Sun, Yong Wang, Mingyue Cai, Liteng Lin, Xiaoyan Chen, Zhong Cao, Kangshun Zhu, Xintao Shuai
Hepatocellular carcinoma (HCC) is one of the most common malignancies imposing a serious threat to human health worldwide. To date, the effect of HCC chemotherapy has been limited due to drug resistance. Combination therapy of chemotherapeutic drugs and siRNA represents an emerging strategy that may improve anticancer effects by synergistic actions. The current study was aimed at achieving better HCC treatment via combination therapy, in which PEI-modified liposomes prepared by a thin-film hydration method were used to codeliver sorafenib (SF) and siRNA targeting GPC3 gene (siGPC3)...
November 6, 2017: Biomaterials Science
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