Agathe L Chédeville, Anbarasu Lourdusamy, Ana Rita Monteiro, Richard Hill, Patricia A Madureira
Glioblastoma (GB) is the most common and deadly type of primary malignant brain tumor with an average patient survival of only 15-17 months. GBs typically have hypoxic regions associated with aggressiveness and chemoresistance. Using patient derived GB cells, we characterized how GB responds to hypoxia. We noted a hypoxia-dependent glycolytic switch characterized by the up-regulation of HK2, PFKFB3, PFKFB4, LDHA, PDK1, SLC2A1 /GLUT-1, CA9 /CAIX, and SLC16A3 /MCT-4. Moreover, many proangiogenic genes and proteins, including VEGFA, VEGFC, VEGFD, PGF /PlGF, ADM, ANGPTL4, and SERPINE1/ PAI-1 were up-regulated during hypoxia...
August 27, 2020: Biomedicines